The power of microRNA regulation—insights into immunity and metabolism

IF 3 4区 生物学 Q1 Biochemistry, Genetics and Molecular Biology
Stefania Oliveto, Nicola Manfrini, Stefano Biffo
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引用次数: 0

Abstract

MicroRNAs (miRNAs) are a prominent class of small non-coding RNAs that control gene expression. This comprehensive review explores the intricate roles of miRNAs in metabolism and immunity, as well as the emerging field of immunometabolism. The core of this work delves into the functional and regulatory capabilities of miRNAs, examining their complex influence on glucose and lipid metabolism, as well as their pivotal roles in shaping T-cell development and function. Specifically, this review addresses how miRNAs orchestrate the complex interaction between cellular metabolic processes and immune responses, underscoring the essential nature of these small regulatory molecules in maintaining homeostasis. Finally, we examine the emerging role of Artificial Intelligence (AI) in miRNA research, focusing on how machine learning techniques are revolutionizing the identification and validation of potential miRNA biomarkers. By integrating these diverse aspects, this review underscores the multifaceted roles of miRNAs in biological processes and their significant potential in advancing biomedical research and clinical applications.

Abstract Image

microRNA调控的力量——对免疫和代谢的洞察。
MicroRNAs (miRNAs)是一类控制基因表达的非编码小rna。这篇综合综述探讨了mirna在代谢和免疫中的复杂作用,以及新兴的免疫代谢领域。这项工作的核心是深入研究mirna的功能和调控能力,研究它们对葡萄糖和脂质代谢的复杂影响,以及它们在塑造t细胞发育和功能中的关键作用。具体来说,这篇综述探讨了mirna如何协调细胞代谢过程和免疫反应之间的复杂相互作用,强调了这些小调节分子在维持体内平衡中的本质。最后,我们研究了人工智能(AI)在miRNA研究中的新兴作用,重点关注机器学习技术如何彻底改变潜在miRNA生物标志物的鉴定和验证。通过整合这些不同的方面,本综述强调了mirna在生物过程中的多方面作用及其在推进生物医学研究和临床应用方面的巨大潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
FEBS Letters
FEBS Letters 生物-生化与分子生物学
CiteScore
7.00
自引率
2.90%
发文量
303
审稿时长
1.0 months
期刊介绍: FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.
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