IF 1.2 4区生物学

Fly Pub Date : 2022-12-01 DOI: 10.1080/19336934.2021.1969220

Augusto Santos Rampasso, Patrick Michael O'Grady

{"title":"Standardized terminology and visual atlas of the external morphology and terminalia for the genus Scaptomyza (Diptera: Drosophilidae).","authors":"Augusto Santos Rampasso, Patrick Michael O'Grady","doi":"10.1080/19336934.2021.1969220","DOIUrl":"https://doi.org/10.1080/19336934.2021.1969220","url":null,"abstract":"ABSTRACT The genus Scaptomyza is one of the two Drosophilidae genera with Hawaiian endemic species. This genus is an excellent model for biogeographic studies since it is distributed throughout the majority of continents, including continental islands, the Hawaiian Islands, and many other remote oceanic islands. This genus currently comprises 273 described species, 148 of which are endemic to the Hawaiian Islands. However, most descriptions were published before efforts to standardizing the morphological terminology across the Diptera were made in the 1980’s. Since research groups developed their own set of terminologies independently, without considering homologies, multiple terms have been used to refer to the same characters. This is especially true for the male terminalia, which have remarkable modifications within the family Drosophilidae. We reviewed the Scaptomyza literature, in addition to other studies across the Drosophilidae and Diptera, compiled the English synonyms, and provided a visual atlas of each body part, indicating how to recognize the morphological characters. The goal of the present study is to facilitate species identification and propose preferred terms to be adopted for future Scaptomyza descriptions.","PeriodicalId":12128,"journal":{"name":"Fly","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39513254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The role of micro RNAs (miRNAs) in the regulation of Drosophila melanogaster's innate immunity. 微rna (miRNAs)在果蝇先天免疫调节中的作用。

IF 1.2 4区生物学

Fly Pub Date : 2022-12-01 DOI: 10.1080/19336934.2022.2149204

Max Yang Lu, Stanislava Chtarbanova

引用次数: 2

A screen of small molecule and genetic modulators of life span in female Drosophila identifies etomoxir, RH5849 and unanticipated temperature effects. 对雌果蝇寿命的小分子和基因调节剂进行筛选，发现了依托莫西尔、RH5849 和意想不到的温度效应。

IF 2.4 4区生物学

Fly Pub Date : 2022-12-01 DOI: 10.1080/19336934.2022.2149209

Gary N Landis, Sebastian Ko, Oscar Peng, Brett Bognar, Michael Khmelkov, Hans S Bell, John Tower

{"title":"A screen of small molecule and genetic modulators of life span in female Drosophila identifies etomoxir, RH5849 and unanticipated temperature effects.","authors":"Gary N Landis, Sebastian Ko, Oscar Peng, Brett Bognar, Michael Khmelkov, Hans S Bell, John Tower","doi":"10.1080/19336934.2022.2149209","DOIUrl":"10.1080/19336934.2022.2149209","url":null,"abstract":"Mifepristone increases life span in female Drosophila melanogaster, and its molecular target(s) remain unclear. Here small molecule and genetic interventions were tested for ability to mimic mifepristone, or to decrease life span in a way that can be rescued by mifepristone. Etomoxir inhibits lipid metabolism, and significantly increased life span in virgin and mated females, but not males, at 50 µM concentration. Pioglitazone is reported to activate both mammalian PPARγ and its Drosophila homolog Eip75B. Pioglitazone produced minor and inconsistent benefits for female Drosophila life span, and only at the lowest concentrations tested. Ecdysone is a Drosophila steroid hormone reported to regulate responses to mating, and RH5849 is a potent mimic of ecdysone. RH5849 reduced virgin female life span, and this was partly rescued by mifepristone. Mifepristone did not compete with RH5849 for activation of an ecdysone receptor (EcR)-responsive transgenic reporter, indicating that the relevant target for mifepristone is not EcR. The conditional GAL4/GAL80ts system was used in attempt to test the effect of an Eip75B RNAi construct on female life span. However, the 29°C temperature used for induction reduced or eliminated mating-induced midgut hypertrophy, the negative life span effects of mating, and the positive life span effects of mifepristone. Even when applied after mating was complete, a shift to 29°C temperature reduced mating-induced midgut hypertrophy by half, and the life span effects of mating by 4.8-fold. Taken together, these results identify promising small molecules for further analysis, and inform the design of experiments involving the GAL4/GAL80ts system.","PeriodicalId":12128,"journal":{"name":"Fly","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9683069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10474700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interorgan communication through peripherally derived peptide hormones in Drosophila. 果蝇通过外周肽类激素进行器官间交流

IF 2.4 4区生物学

Fly Pub Date : 2022-12-01 DOI: 10.1080/19336934.2022.2061834

Naoki Okamoto, Akira Watanabe

引用次数: 0

Notch Signalling Under Maternal-to-Zygotic Transition. 母系转合子过程中的Notch信号传导。

IF 1.2 4区生物学

Fly Pub Date : 2022-12-01 DOI: 10.1080/19336934.2022.2139981

Tomoko Yamakawa, Elzava Yuslimatin Mujizah, Kenji Matsuno

{"title":"Notch Signalling Under Maternal-to-Zygotic Transition.","authors":"Tomoko Yamakawa, Elzava Yuslimatin Mujizah, Kenji Matsuno","doi":"10.1080/19336934.2022.2139981","DOIUrl":"https://doi.org/10.1080/19336934.2022.2139981","url":null,"abstract":"The development of all animal embryos is initially directed by the gene products supplied by their mothers. With the progression of embryogenesis, the embryo's genome is activated to command subsequent developments. This transition, which has been studied in many model animals, is referred to as the Maternal-to-Zygotic Transition (MZT). In many organisms, including flies, nematodes, and sea urchins, genes involved in Notch signaling are extensively influenced by the MZT. This signaling pathway is highly conserved across metazoans; moreover, it regulates various developmental processes. Notch signaling defects are commonly associated with various human diseases. The maternal contribution of its factors was first discovered in flies. Subsequently, several genes were identified from mutant embryos with a phenotype similar to Notch mutants only upon the removal of the maternal contributions. Studies on these maternal genes have revealed various novel steps in the cascade of Notch signal transduction. Among these genes, pecanex and almondex have been functionally characterized in recent studies. Therefore, in this review, we will focus on the roles of these two maternal genes in Notch signaling and discuss future research directions on its maternal function.","PeriodicalId":12128,"journal":{"name":"Fly","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10472596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The chemosensory system of the Drosophila larva: an overview of current understanding. 果蝇幼虫的化学感觉系统:当前认识的概述。

IF 1.2 4区生物学

Fly Pub Date : 2022-12-01 DOI: 10.1080/19336934.2021.1953364

Nikita Komarov, Simon G Sprecher

引用次数: 3

Characterization of enhancer fragments in Drosophila robo2. 果蝇 robo2 中增强子片段的特征。

IF 2.4 4区生物学

Fly Pub Date : 2022-12-01 DOI: 10.1080/19336934.2022.2126259

Gina Hauptman, Marie C Reichert, Muna A Abdal Rhida, Timothy A Evans

{"title":"Characterization of enhancer fragments in Drosophila robo2.","authors":"Gina Hauptman, Marie C Reichert, Muna A Abdal Rhida, Timothy A Evans","doi":"10.1080/19336934.2022.2126259","DOIUrl":"10.1080/19336934.2022.2126259","url":null,"abstract":"Receptor proteins of the Roundabout (Robo) family regulate axon guidance decisions during nervous system development. Among the three Drosophila robo family genes (robo1, robo2 and robo3), robo2 displays a dynamic expression pattern and regulates multiple axon guidance outcomes, including preventing midline crossing in some axons, promoting midline crossing in others, forming lateral longitudinal axon pathways, and regulating motor axon guidance. The identity and location of enhancer elements regulating robo2's complex and dynamic expression pattern in different neural cell types are unknown. Here, we characterize a set of 17 transgenic lines expressing GAL4 under the control of DNA sequences derived from noncoding regions in and around robo2, to identify enhancers controlling specific aspects of robo2 expression in the embryonic ventral nerve cord. We identify individual fragments that confer expression in specific cell types where robo2 is known to function, including early pioneer neurons, midline glia and lateral longitudinal neurons. Our results indicate that robo2's dynamic expression pattern is specified by a combination of enhancer elements that are active in different subsets of cells. We show that robo2's expression in lateral longitudinal axons represents two genetically separable subsets of neurons, and compare their axon projections with each other and with Fasciclin II (FasII), a commonly used marker of longitudinal axon pathways. In addition, we provide a general description of each fragment's expression in embryonic tissues outside of the nervous system, to serve as a resource for other researchers interested in robo2 expression and its functional roles outside the central nervous system.","PeriodicalId":12128,"journal":{"name":"Fly","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3b/61/KFLY_16_2126259.PMC9559326.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10478241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic movement and turnover of extracellular matrices during tissue development and maintenance. 细胞外基质在组织发育和维持过程中的动态运动和周转。

IF 2.4 4区生物学

Fly Pub Date : 2022-12-01 DOI: 10.1080/19336934.2022.2076539

Yutaka Matsubayashi

引用次数: 0

Cellular mechanisms underlying adult tissue plasticity in Drosophila. 果蝇成体组织可塑性的细胞机制。

IF 1.2 4区生物学

Fly Pub Date : 2022-12-01 DOI: 10.1080/19336934.2022.2066952

Hiroki Nagai, Masayuki Miura, Yu-Ichiro Nakajima

引用次数: 5

A standardized nomenclature and atlas of the female terminalia of Drosophila melanogaster. 黑腹果蝇雌性末端的标准命名法和图集。

IF 1.2 4区生物学

Fly Pub Date : 2022-12-01 DOI: 10.1080/19336934.2022.2058309

Eden W McQueen, Mehrnaz Afkhami, Joel Atallah, John M Belote, Nicolas Gompel, Yael Heifetz, Yoshitaka Kamimura, Shani C Kornhauser, John P Masly, Patrick O'Grady, Julianne Peláez, Mark Rebeiz, Gavin Rice, Ernesto Sánchez-Herrero, Maria Daniela Santos Nunes, Augusto Santos Rampasso, Sandra L Schnakenberg, Mark L Siegal, Aya Takahashi, Kentaro M Tanaka, Natascha Turetzek, Einat Zelinger, Virginie Courtier-Orgogozo, Masanori J Toda, Mariana F Wolfner, Amir Yassin

{"title":"A standardized nomenclature and atlas of the female terminalia of Drosophila melanogaster.","authors":"Eden W McQueen, Mehrnaz Afkhami, Joel Atallah, John M Belote, Nicolas Gompel, Yael Heifetz, Yoshitaka Kamimura, Shani C Kornhauser, John P Masly, Patrick O'Grady, Julianne Peláez, Mark Rebeiz, Gavin Rice, Ernesto Sánchez-Herrero, Maria Daniela Santos Nunes, Augusto Santos Rampasso, Sandra L Schnakenberg, Mark L Siegal, Aya Takahashi, Kentaro M Tanaka, Natascha Turetzek, Einat Zelinger, Virginie Courtier-Orgogozo, Masanori J Toda, Mariana F Wolfner, Amir Yassin","doi":"10.1080/19336934.2022.2058309","DOIUrl":"https://doi.org/10.1080/19336934.2022.2058309","url":null,"abstract":"The model organism Drosophila melanogaster has become a focal system for investigations of rapidly evolving genital morphology as well as the development and functions of insect reproductive structures. To follow up on a previous paper outlining unifying terminology for the structures of the male terminalia in this species, we offer here a detailed description of the female terminalia of D. melanogaster. Informative diagrams and micrographs are presented to provide a comprehensive overview of the external and internal reproductive structures of females. We propose a collection of terms and definitions to standardize the terminology associated with the female terminalia in D. melanogaster and we provide a correspondence table with the terms previously used. Unifying terminology for both males and females in this species will help to facilitate communication between various disciplines, as well as aid in synthesizing research across publications within a discipline that has historically focused principally on male features. Our efforts to refine and standardize the terminology should expand the utility of this important model system for addressing questions related to the development and evolution of animal genitalia, and morphology in general.","PeriodicalId":12128,"journal":{"name":"Fly","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9654254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

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