IF 2.4 4区生物学

Fly Pub Date : 2022-12-01 DOI: 10.1080/19336934.2022.2061834

Naoki Okamoto, Akira Watanabe

引用次数: 0

Dynamic movement and turnover of extracellular matrices during tissue development and maintenance. 细胞外基质在组织发育和维持过程中的动态运动和周转。

IF 2.4 4区生物学

Fly Pub Date : 2022-12-01 DOI: 10.1080/19336934.2022.2076539

Yutaka Matsubayashi

引用次数: 0

Notch Signalling Under Maternal-to-Zygotic Transition. 母系转合子过程中的Notch信号传导。

IF 1.2 4区生物学

Fly Pub Date : 2022-12-01 DOI: 10.1080/19336934.2022.2139981

Tomoko Yamakawa, Elzava Yuslimatin Mujizah, Kenji Matsuno

{"title":"Notch Signalling Under Maternal-to-Zygotic Transition.","authors":"Tomoko Yamakawa, Elzava Yuslimatin Mujizah, Kenji Matsuno","doi":"10.1080/19336934.2022.2139981","DOIUrl":"https://doi.org/10.1080/19336934.2022.2139981","url":null,"abstract":"The development of all animal embryos is initially directed by the gene products supplied by their mothers. With the progression of embryogenesis, the embryo's genome is activated to command subsequent developments. This transition, which has been studied in many model animals, is referred to as the Maternal-to-Zygotic Transition (MZT). In many organisms, including flies, nematodes, and sea urchins, genes involved in Notch signaling are extensively influenced by the MZT. This signaling pathway is highly conserved across metazoans; moreover, it regulates various developmental processes. Notch signaling defects are commonly associated with various human diseases. The maternal contribution of its factors was first discovered in flies. Subsequently, several genes were identified from mutant embryos with a phenotype similar to Notch mutants only upon the removal of the maternal contributions. Studies on these maternal genes have revealed various novel steps in the cascade of Notch signal transduction. Among these genes, pecanex and almondex have been functionally characterized in recent studies. Therefore, in this review, we will focus on the roles of these two maternal genes in Notch signaling and discuss future research directions on its maternal function.","PeriodicalId":12128,"journal":{"name":"Fly","volume":"16 1","pages":"347-359"},"PeriodicalIF":1.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10472596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Characterization of enhancer fragments in Drosophila robo2. 果蝇 robo2 中增强子片段的特征。

IF 2.4 4区生物学

Fly Pub Date : 2022-12-01 DOI: 10.1080/19336934.2022.2126259

Gina Hauptman, Marie C Reichert, Muna A Abdal Rhida, Timothy A Evans

{"title":"Characterization of enhancer fragments in Drosophila robo2.","authors":"Gina Hauptman, Marie C Reichert, Muna A Abdal Rhida, Timothy A Evans","doi":"10.1080/19336934.2022.2126259","DOIUrl":"10.1080/19336934.2022.2126259","url":null,"abstract":"Receptor proteins of the Roundabout (Robo) family regulate axon guidance decisions during nervous system development. Among the three Drosophila robo family genes (robo1, robo2 and robo3), robo2 displays a dynamic expression pattern and regulates multiple axon guidance outcomes, including preventing midline crossing in some axons, promoting midline crossing in others, forming lateral longitudinal axon pathways, and regulating motor axon guidance. The identity and location of enhancer elements regulating robo2's complex and dynamic expression pattern in different neural cell types are unknown. Here, we characterize a set of 17 transgenic lines expressing GAL4 under the control of DNA sequences derived from noncoding regions in and around robo2, to identify enhancers controlling specific aspects of robo2 expression in the embryonic ventral nerve cord. We identify individual fragments that confer expression in specific cell types where robo2 is known to function, including early pioneer neurons, midline glia and lateral longitudinal neurons. Our results indicate that robo2's dynamic expression pattern is specified by a combination of enhancer elements that are active in different subsets of cells. We show that robo2's expression in lateral longitudinal axons represents two genetically separable subsets of neurons, and compare their axon projections with each other and with Fasciclin II (FasII), a commonly used marker of longitudinal axon pathways. In addition, we provide a general description of each fragment's expression in embryonic tissues outside of the nervous system, to serve as a resource for other researchers interested in robo2 expression and its functional roles outside the central nervous system.","PeriodicalId":12128,"journal":{"name":"Fly","volume":"16 1","pages":"312-346"},"PeriodicalIF":2.4,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3b/61/KFLY_16_2126259.PMC9559326.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10478241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular mechanisms underlying adult tissue plasticity in Drosophila. 果蝇成体组织可塑性的细胞机制。

IF 1.2 4区生物学

Fly Pub Date : 2022-12-01 DOI: 10.1080/19336934.2022.2066952

Hiroki Nagai, Masayuki Miura, Yu-Ichiro Nakajima

{"title":"Cellular mechanisms underlying adult tissue plasticity in Drosophila.","authors":"Hiroki Nagai, Masayuki Miura, Yu-Ichiro Nakajima","doi":"10.1080/19336934.2022.2066952","DOIUrl":"https://doi.org/10.1080/19336934.2022.2066952","url":null,"abstract":"Adult tissues in Metazoa dynamically remodel their structures in response to environmental challenges including sudden injury, pathogen infection, and nutritional fluctuation, while maintaining quiescence under homoeostatic conditions. This characteristic, hereafter referred to as adult tissue plasticity, can prevent tissue dysfunction and improve the fitness of organisms in continuous and/or severe change of environments. With its relatively simple tissue structures and genetic tools, studies using the fruit fly Drosophila melanogaster have provided insights into molecular mechanisms that control cellular responses, particularly during regeneration and nutrient adaptation. In this review, we present the current understanding of cellular mechanisms, stem cell proliferation, polyploidization, and cell fate plasticity, all of which enable adult tissue plasticity in various Drosophila adult organs including the midgut, the brain, and the gonad, and discuss the organismal strategy in response to environmental changes and future directions of the research.","PeriodicalId":12128,"journal":{"name":"Fly","volume":"16 1","pages":"190-206"},"PeriodicalIF":1.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9546157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

A standardized nomenclature and atlas of the female terminalia of Drosophila melanogaster. 黑腹果蝇雌性末端的标准命名法和图集。

IF 1.2 4区生物学

Fly Pub Date : 2022-12-01 DOI: 10.1080/19336934.2022.2058309

Eden W McQueen, Mehrnaz Afkhami, Joel Atallah, John M Belote, Nicolas Gompel, Yael Heifetz, Yoshitaka Kamimura, Shani C Kornhauser, John P Masly, Patrick O'Grady, Julianne Peláez, Mark Rebeiz, Gavin Rice, Ernesto Sánchez-Herrero, Maria Daniela Santos Nunes, Augusto Santos Rampasso, Sandra L Schnakenberg, Mark L Siegal, Aya Takahashi, Kentaro M Tanaka, Natascha Turetzek, Einat Zelinger, Virginie Courtier-Orgogozo, Masanori J Toda, Mariana F Wolfner, Amir Yassin

{"title":"A standardized nomenclature and atlas of the female terminalia of Drosophila melanogaster.","authors":"Eden W McQueen, Mehrnaz Afkhami, Joel Atallah, John M Belote, Nicolas Gompel, Yael Heifetz, Yoshitaka Kamimura, Shani C Kornhauser, John P Masly, Patrick O'Grady, Julianne Peláez, Mark Rebeiz, Gavin Rice, Ernesto Sánchez-Herrero, Maria Daniela Santos Nunes, Augusto Santos Rampasso, Sandra L Schnakenberg, Mark L Siegal, Aya Takahashi, Kentaro M Tanaka, Natascha Turetzek, Einat Zelinger, Virginie Courtier-Orgogozo, Masanori J Toda, Mariana F Wolfner, Amir Yassin","doi":"10.1080/19336934.2022.2058309","DOIUrl":"https://doi.org/10.1080/19336934.2022.2058309","url":null,"abstract":"The model organism Drosophila melanogaster has become a focal system for investigations of rapidly evolving genital morphology as well as the development and functions of insect reproductive structures. To follow up on a previous paper outlining unifying terminology for the structures of the male terminalia in this species, we offer here a detailed description of the female terminalia of D. melanogaster. Informative diagrams and micrographs are presented to provide a comprehensive overview of the external and internal reproductive structures of females. We propose a collection of terms and definitions to standardize the terminology associated with the female terminalia in D. melanogaster and we provide a correspondence table with the terms previously used. Unifying terminology for both males and females in this species will help to facilitate communication between various disciplines, as well as aid in synthesizing research across publications within a discipline that has historically focused principally on male features. Our efforts to refine and standardize the terminology should expand the utility of this important model system for addressing questions related to the development and evolution of animal genitalia, and morphology in general.","PeriodicalId":12128,"journal":{"name":"Fly","volume":"16 1","pages":"128-151"},"PeriodicalIF":1.2,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9116418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9654254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Cell-cell interactions that drive tumorigenesis in Drosophila. 驱动果蝇肿瘤发生的细胞-细胞相互作用。

IF 1.2 4区生物学

Fly Pub Date : 2022-12-01 DOI: 10.1080/19336934.2022.2148828

Masato Enomoto, Tatsushi Igaki

引用次数: 2

Cell mechanics and cell-cell recognition controls by Toll-like receptors in tissue morphogenesis and homeostasis Toll样受体在组织形态发生和稳态中的细胞力学和细胞-细胞识别控制

IF 1.2 4区生物学

Fly Pub Date : 2022-05-17 DOI: 10.1080/19336934.2022.2074783

Daiki Umetsu

引用次数: 5

Cutting edge technologies expose the temporal regulation of neurogenesis in the Drosophila nervous system 尖端技术揭示了果蝇神经系统神经发生的时间调节

IF 1.2 4区生物学

Fly Pub Date : 2022-05-13 DOI: 10.1080/19336934.2022.2073158

Makoto Sato, Takumi Suzuki

{"title":"Cutting edge technologies expose the temporal regulation of neurogenesis in the Drosophila nervous system","authors":"Makoto Sato, Takumi Suzuki","doi":"10.1080/19336934.2022.2073158","DOIUrl":"https://doi.org/10.1080/19336934.2022.2073158","url":null,"abstract":"ABSTRACT During the development of the central nervous system (CNS), extremely large numbers of neurons are produced in a regular fashion to form precise neural circuits. During this process, neural progenitor cells produce different neurons over time due to their intrinsic gene regulatory mechanisms as well as extrinsic mechanisms. The Drosophila CNS has played an important role in elucidating the temporal mechanisms that control neurogenesis over time. It has been shown that a series of temporal transcription factors are sequentially expressed in neural progenitor cells and regulate the temporal specification of neurons in the embryonic CNS. Additionally, similar mechanisms are found in the developing optic lobe and central brain in the larval CNS. However, it is difficult to elucidate the function of numerous molecules in many different cell types solely by molecular genetic approaches. Recently, omics analysis using single-cell RNA-seq and other methods has been used to study the Drosophila nervous system on a large scale and is making a significant contribution to the understanding of the temporal mechanisms of neurogenesis. In this article, recent findings on the temporal patterning of neurogenesis and the contributions of cutting-edge technologies will be reviewed.","PeriodicalId":12128,"journal":{"name":"Fly","volume":"16 1","pages":"222 - 232"},"PeriodicalIF":1.2,"publicationDate":"2022-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49020058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Biology and ecology of the Oriental flower-breeding Drosophila elegans and related species 东方繁花果蝇及其近缘种的生物学与生态学

IF 1.2 4区生物学

Fly Pub Date : 2022-05-01 DOI: 10.1080/19336934.2022.2066953

Yuki Ishikawa, M. Kimura, M. Toda

引用次数: 4

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