IF 1.2 4区生物学

Fly Pub Date : 2017-07-03 Epub Date: 2017-02-21 DOI: 10.1080/19336934.2017.1297350

Martin Kunc, Badrul Arefin, Pavel Hyrsl, Ulrich Theopold

引用次数: 10

Cells on the move: Modulation of guidance cues during germ cell migration. 移动中的细胞:生殖细胞迁移过程中引导信号的调节。

IF 1.2 4区生物学

Fly Pub Date : 2017-07-03 Epub Date: 2017-03-16 DOI: 10.1080/19336934.2017.1304332

Girish Deshpande, Justinn Barr, Offer Gerlitz, Lyubov Lebedeva, Yulii Shidlovskii, Paul Schedl

{"title":"Cells on the move: Modulation of guidance cues during germ cell migration.","authors":"Girish Deshpande, Justinn Barr, Offer Gerlitz, Lyubov Lebedeva, Yulii Shidlovskii, Paul Schedl","doi":"10.1080/19336934.2017.1304332","DOIUrl":"https://doi.org/10.1080/19336934.2017.1304332","url":null,"abstract":"In Drosophila melanogaster the progenitors of the germ-line stem cells, the primordial germ cells (PGCs) are formed on the outside surface of the early embryo, while the somatic gonadal precursor cells (SGPs) are specified during mid-embryogenesis. To form the primitive embryonic gonad, the PGCs travel from outside of the embryo, across the mid-gut and then migrate through the mesoderm to the SGPs. The migratory path of PGCs is dictated by a series of attractive and repulsive cues. Studies in our laboratory have shown that one of the key chemoattractants is the Hedgehog (Hh) ligand. Although, Hh is expressed in other cell types, the long-distance transmission of this ligand is specifically potentiated in the SGPs by the hmgcr isoprenoid biosynthetic pathway. The distant transmission of the Hh ligand is gated by restricting expression of hmgcr to the SGPs. This is particularly relevant in light of the recent findings that an ABC transporter, mdr49 also acts in a mesoderm specific manner to release the germ cell attractant. Our studies have demonstrated that mdr49 functions in hh signaling likely via its role in the transport of cholesterol. Given the importance of cholesterol in the processing and long distance transmission of the Hh ligand, this observation has opened up an exciting avenue concerning the possible role of components of the sterol transport machinery in PGC migration.","PeriodicalId":12128,"journal":{"name":"Fly","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2017-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336934.2017.1304332","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34817529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Strategy changes in subsequent fights as consequences of winning and losing in fruit fly fights 在随后的战斗中，策略会随着果蝇战斗的输赢而改变

IF 1.2 4区生物学

Fly Pub Date : 2017-04-03 DOI: 10.1080/19336934.2016.1259041

Severine Trannoy, E. Kravitz

{"title":"Strategy changes in subsequent fights as consequences of winning and losing in fruit fly fights","authors":"Severine Trannoy, E. Kravitz","doi":"10.1080/19336934.2016.1259041","DOIUrl":"https://doi.org/10.1080/19336934.2016.1259041","url":null,"abstract":"ABSTRACT In competition for food, territory and mates, male fruit flies (Drosophila melanogaster) engage in agonistic encounters with conspecifics. The fighting strategies used to obtain these resources are influenced by previous and present experience, environmental cues, and the internal state of the animal including hormonal and genetic influences. Animals that experience prior defeats show submissive behavior and are more likely to lose 2nd contests, while animals that win 1st fights are more aggressive and have a higher probability of winning 2nd contests. In a recent report, we examined these loser and winner effects in greater detail and demonstrated that both winners and losers show short-term memory of the results of previous bouts while only losers demonstrate a longer-term memory that requires protein synthesis. The recent findings also suggested that an individual recognition mechanism likely exists that can serve important roles in evaluating the fighting ability of opponents and influencing future fighting strategy. In this article, we follow up on these results by asking how previous defeated and victorious flies change their fighting strategies in the presence of 2nd losing and winning flies, by searching for evidence of territory marking, and discussing the existing literature in light of our findings.","PeriodicalId":12128,"journal":{"name":"Fly","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2017-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336934.2016.1259041","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42903404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Somatic recombination in adult tissues: What is there to learn? 成人组织中的体细胞重组:有什么值得学习的?

IF 1.2 4区生物学

Fly Pub Date : 2017-04-03 DOI: 10.1080/19336934.2016.1249073

Katarzyna Siudeja, Allison J. Bardin

引用次数: 11

Trans-inactivation: Repression in a wrong place. 反式失活:抑制在错误的地方。

IF 1.2 4区生物学

Fly Pub Date : 2017-04-03 Epub Date: 2016-08-19 DOI: 10.1080/19336934.2016.1225634

Aleksei S Shatskikh, Yuriy A Abramov, Sergey A Lavrov

{"title":"Trans-inactivation: Repression in a wrong place.","authors":"Aleksei S Shatskikh, Yuriy A Abramov, Sergey A Lavrov","doi":"10.1080/19336934.2016.1225634","DOIUrl":"https://doi.org/10.1080/19336934.2016.1225634","url":null,"abstract":"Trans-inactivation is the repression of genes on a normal chromosome under the influence of a rearranged homologous chromosome demonstrating the position effect variegation (PEV). This phenomenon was studied in detail on the example of brownDominant allele causing the repression of wild-type brown gene on the opposite chromosome. We have investigated another trans-inactivation-inducing chromosome rearrangement, In(2)A4 inversion. In both cases, brownDominant and In(2)A4, the repression seems to be the result of dragging of the euchromatic region of the normal chromosome into the heterochromatic environment. It was found that cis-inactivation (classical PEV) and trans-inactivation show different patterns of distribution along the chromosome and respond differently to PEV modifying genes. It appears that the causative mechanism of trans-inactivation is de novo heterochromatin assembly on euchromatic sequences dragged into the heterochromatic nuclear compartment. Trans-inactivation turns out to be the result of a combination of heterochromatin-induced position effect and the somatic interphase chromosome pairing that is widespread in Diptera.","PeriodicalId":12128,"journal":{"name":"Fly","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2017-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336934.2016.1225634","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34320349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

What does the fruitless gene tell us about nature vs. nurture in the sex life of Drosophila? 在果蝇的性生活中，无果基因告诉了我们什么关于先天与后天的区别?

IF 1.2 4区生物学

Fly Pub Date : 2017-04-03 DOI: 10.1080/19336934.2016.1263778

D. Yamamoto, Soh Kohatsu

引用次数: 11

Control of non-apoptotic nurse cell death by engulfment genes in Drosophila 吞噬基因对果蝇非凋亡护理细胞死亡的控制

IF 1.2 4区生物学

Fly Pub Date : 2017-04-03 DOI: 10.1080/19336934.2016.1238993

Allison K Timmons, Albert A Mondragon, Tracy L. Meehan, K. McCall

{"title":"Control of non-apoptotic nurse cell death by engulfment genes in Drosophila","authors":"Allison K Timmons, Albert A Mondragon, Tracy L. Meehan, K. McCall","doi":"10.1080/19336934.2016.1238993","DOIUrl":"https://doi.org/10.1080/19336934.2016.1238993","url":null,"abstract":"ABSTRACT Programmed cell death occurs as a normal part of oocyte development in Drosophila. For each egg that is formed, 15 germline-derived nurse cells transfer their cytoplasmic contents into the oocyte and die. Disruption of apoptosis or autophagy only partially inhibits the death of the nurse cells, indicating that other mechanisms significantly contribute to nurse cell death. Recently, we demonstrated that the surrounding stretch follicle cells non-autonomously promote nurse cell death during late oogenesis and that phagocytosis genes including draper, ced-12, and the JNK pathway are crucial for this process. When phagocytosis genes are inhibited in the follicle cells, events specifically associated with death of the nurse cells are impaired. Death of the nurse cells is not completely blocked in draper mutants, suggesting that other engulfment receptors are involved. Indeed, we found that the integrin subunit, αPS3, is enriched on stretch follicle cells during late oogenesis and is required for elimination of the nurse cells. Moreover, double mutant analysis revealed that integrins act in parallel to draper. Death of nurse cells in the Drosophila ovary is a unique example of programmed cell death that is both non-apoptotic and non-cell autonomously controlled.","PeriodicalId":12128,"journal":{"name":"Fly","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2017-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336934.2016.1238993","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43353624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Parsimony and complexity: Cell fate assignment in the developing Drosophila eye 简约与复杂:发育中的果蝇眼睛的细胞命运分配

IF 1.2 4区生物学

Fly Pub Date : 2017-02-23 DOI: 10.1080/19336934.2017.1291103

Y. Mavromatakis, A. Tomlinson

{"title":"Parsimony and complexity: Cell fate assignment in the developing Drosophila eye","authors":"Y. Mavromatakis, A. Tomlinson","doi":"10.1080/19336934.2017.1291103","DOIUrl":"https://doi.org/10.1080/19336934.2017.1291103","url":null,"abstract":"ABSTRACT The specification of the R7 photoreceptor in the Drosophila eye has become a classic model for understanding how cell fates are assigned in developing systems. R7 is derived from a group of cells that also gives rise to the R1/6 photoreceptor class and the non-photoreceptor cone cells. Our studies examine the signals and cellular information that direct each of these cell types. The cell fates are directed by the combined actions of the Receptor Tyrosine Kinase (RTK) and Notch (N) signaling pathways. The RTK pathway acts to remove the transcription factor Tramtrack (Ttk) which represses the photoreceptor fate. If a cell receives an RTK signal sufficient to remove Ttk then the photoreceptor fate is specified; if not, the cone cell fate results. If Ttk is removed from a cell and its N activity is high then it is specified as an R7, but if its N activity is low then it becomes an R1/6 class photoreceptor. Thus, a remarkably simple molecular code underlies the specification of the fates: 1. Ttk degraded or not: 2. N activity high or low. In the R1/6 and cone cell precursors the molecular codes are achieved with relative simplicity but in the R7 precursor, manifold interactions occur between the RTK and N pathways, and to-date we have identified 4 distinct roles played by N in R7 fate specification. In this review we detail this molecular complexity, and describe how the RTK/N pathway crosstalk eventually leads to the simple molecular code of Tramtrack removed and N activity high. Furthermore, we describe the role played by the transcription factor Lozenge (Lz) in directing retinal precursor fates, and how the RTK/N signals specify different retinal cell types depending on the presence or absence of Lz.","PeriodicalId":12128,"journal":{"name":"Fly","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2017-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336934.2017.1291103","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46832024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Gluconeogenesis: An ancient biochemical pathway with a new twist 糖异生:一个古老的生化途径与一个新的转折

IF 1.2 4区生物学

Fly Pub Date : 2017-02-07 DOI: 10.1080/19336934.2017.1283081

T. Miyamoto, H. Amrein

引用次数: 30

secHsp70 as a tool to approach amyloid-β42 and other extracellular amyloids secHsp70作为接近淀粉样蛋白-β42和其他细胞外淀粉样蛋白的工具

IF 1.2 4区生物学

Fly Pub Date : 2017-02-06 DOI: 10.1080/19336934.2017.1291104

Lorena de Mena, D. Chhangani, P. Fernandez-Funez, D. Rincon-Limas

{"title":"secHsp70 as a tool to approach amyloid-β42 and other extracellular amyloids","authors":"Lorena de Mena, D. Chhangani, P. Fernandez-Funez, D. Rincon-Limas","doi":"10.1080/19336934.2017.1291104","DOIUrl":"https://doi.org/10.1080/19336934.2017.1291104","url":null,"abstract":"ABSTRACT Self-association of amyloidogenic proteins is the main pathological trigger in a wide variety of neurodegenerative disorders. These aggregates are deposited inside or outside the cell due to hereditary mutations, environmental exposures or even normal aging. Cumulative evidence indicates that the heat shock chaperone Hsp70 possesses robust neuroprotection against various intracellular amyloids in Drosophila and mouse models. However, its protective role against extracellular amyloids was largely unknown as its presence outside the cells is very limited. Our recent manuscript in PNAS revealed that an engineered form of secreted Hsp70 (secHsp70) is highly protective against toxicity induced by extracellular deposition of the amyloid-β42 (Aβ42) peptide. In this Extra View article, we extend our analysis to other members of the heat shock protein family. We created PhiC31-based transgenic lines for human Hsp27, Hsp40, Hsp60 and Hsp70 and compared their activities in parallel against extracellular Aβ42. Strikingly, only secreted Hsp70 exhibits robust protection against Aβ42-triggered toxicity in the extracellular milieu. These observations indicate that the ability of secHsp70 to suppress Aβ42 insults is quite unique and suggest that targeted secretion of Hsp70 may represent a new therapeutic approach against Aβ42 and other extracellular amyloids. The potential applications of this engineered chaperone are discussed.","PeriodicalId":12128,"journal":{"name":"Fly","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2017-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336934.2017.1291104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42649161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

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