Methods to investigate the structure and connectivity of the nervous system.

IF 2.4 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Fly Pub Date : 2017-07-03 Epub Date: 2017-02-16 DOI:10.1080/19336934.2017.1295189

Donghyung Lee, Ting-Hao Huang, Aubrie De La Cruz, Antuca Callejas, Carlos Lois

引用次数: 12

Abstract

Understanding the computations that take place in neural circuits requires identifying how neurons in those circuits are connected to one another. In addition, recent research indicates that aberrant neuronal wiring may be the cause of several neurodevelopmental disorders, further emphasizing the importance of identifying the wiring diagrams of brain circuits. To address this issue, several new approaches have been recently developed. In this review, we describe several methods that are currently available to investigate the structure and connectivity of the brain, and discuss their strengths and limitations.

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方法:研究神经系统的结构和连通性。

要理解神经回路中发生的计算，就需要确定这些回路中的神经元是如何相互连接的。此外，最近的研究表明，异常的神经元布线可能是几种神经发育障碍的原因，进一步强调了识别脑回路接线图的重要性。为了解决这个问题，最近发展了几种新的方法。在这篇综述中，我们描述了几种目前可用来研究大脑结构和连接的方法，并讨论了它们的优势和局限性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fly 生物-生化与分子生物学

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

>12 weeks

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