Fly最新文献 - Book学术

RP gene haploinsufficiency promotes extra sensory organ formation via a threshold effect. RP基因单倍不足通过阈值效应促进额外感觉器官的形成。

IF 2.2 4区生物学

Fly Pub Date : 2026-12-01 Epub Date: 2026-01-06 DOI: 10.1080/19336934.2025.2606496

Haiwei Pi, Kuan-Han Chen, Hsin Tu, Chung-Wei Hsu

{"title":"RP gene haploinsufficiency promotes extra sensory organ formation via a threshold effect.","authors":"Haiwei Pi, Kuan-Han Chen, Hsin Tu, Chung-Wei Hsu","doi":"10.1080/19336934.2025.2606496","DOIUrl":"10.1080/19336934.2025.2606496","url":null,"abstract":"Ribosomal protein (RP) gene haploinsufficiency is a conserved form of ribosome dysfunction across species and underlies a class of disorders known as ribosomopathies. In Drosophila, RP gene haploinsufficiency manifests as the Minute phenotype, characterized by thinner and shorter mechanosensory bristles. The development of both bristles and proprioceptive campaniform sensilla (CS) is initiated by the bHLH proneural proteins Achaete (Ac) and Scute (Sc). By analysing genetic interactions between ac sc mutants and Minute mutants of varying severity, we identified a novel bristle-promoting effect that occurs only in the strongly affected Minutes in which the average bristle length is shorter than a threshold. This threshold-dependent effect also promotes ectopic CS formation in the strong Minutes. Transcriptomic analyses comparing the sensory organ - promoting and non-promoting Minutes revealed significant differences in stress-response pathways, including differentially elevated expression of the Xrp1-Irbp18 transcriptional dimer. Notably, mutation of Xrp1 suppresses the ectopic CS phenotype, indicating a positive regulatory role. These findings reveal a previously unrecognized threshold effect in RP gene haploinsufficiency, in which excessive Xrp1 activity promotes supernumerary sensory organ formation, suggesting a compensatory mechanism that modulates neurogenesis under severe ribosomal stress.","PeriodicalId":12128,"journal":{"name":"Fly","volume":"20 1","pages":"2606496"},"PeriodicalIF":2.2,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12778873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sulphur-containing amino acids promote the expression of CG33474 and its neighbouring genes through the transsulphuration pathway. 含硫氨基酸通过转硫途径促进CG33474及其邻近基因的表达。

IF 1.4 4区生物学

Fly Pub Date : 2026-12-01 Epub Date: 2026-04-12 DOI: 10.1080/19336934.2026.2650576

Lulin Xu, Meng Liu, Li He

{"title":"Sulphur-containing amino acids promote the expression of CG33474 and its neighbouring genes through the transsulphuration pathway.","authors":"Lulin Xu, Meng Liu, Li He","doi":"10.1080/19336934.2026.2650576","DOIUrl":"10.1080/19336934.2026.2650576","url":null,"abstract":"Sulphur-containing amino acids (SAAs), including methionine and cysteine, play crucial roles in antioxidant defence, anti-ageing, cytoprotection, and anti-inflammatory responses. Previous studies have shown that SAAs promote peroxisome elevation and fat loss by inducing the expression of the peroxisome-related gene CG33474 in the Drosophila fat body. However, the underlying regulatory mechanism remains unclear. In this study, we demonstrated that the transsulphuration pathway contributes to CG33474 induction, as supplementation with specific downstream metabolites of this pathway recapitulates this effect. Moreover, we found that SAAs upregulate not only CG33474 but also several neighbouring genes - including CG11825, Prx2540-1, Prx2540-2, and CG12896 - suggesting coordinated regulation within this genomic locus. Through fluorescence reporter assays, we discovered that a ~1 kb genomic region upstream of CG33474 harbours the cis-regulatory element mediating SAA responsiveness and that this responsiveness is fat body-specific. Finally, our data suggest that induction of CG33474 may play a role in resistance to different stresses and in regulating ageing as fat body-specific overexpression of CG33474 significantly extends lifespan in Drosophila. Together, our findings reveal that SAAs modulate the expression of CG33474 and its adjacent genes through the transsulphuration pathway, providing an additional mechanistic basis for the antioxidant effects of SAAs.","PeriodicalId":12128,"journal":{"name":"Fly","volume":"20 1","pages":"2650576"},"PeriodicalIF":1.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13078233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147671595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on "Duox-driven ROS release by glia promotes regeneration in the adult Drosophila brain". “神经胶质双驱动ROS释放促进成年果蝇大脑再生”评论。

IF 1.4 4区生物学

Fly Pub Date : 2026-12-01 Epub Date: 2026-07-01 DOI: 10.1080/19336934.2026.2689814

Eli C Scott, Grace Boekhoff-Falk

引用次数: 0

Application, ecotoxicology and regulation of insecticides with special reference to neonicotinoids. 杀虫剂的应用、生态毒理学和法规，特别是新烟碱类。

IF 1.4 4区生物学

Fly Pub Date : 2026-12-01 Epub Date: 2026-05-26 DOI: 10.1080/19336934.2026.2677279

David Hunter, Robert Black

{"title":"Application, ecotoxicology and regulation of insecticides with special reference to neonicotinoids.","authors":"David Hunter, Robert Black","doi":"10.1080/19336934.2026.2677279","DOIUrl":"10.1080/19336934.2026.2677279","url":null,"abstract":"This review examines the efficacy and toxicity of the major insecticide groups in current use, with particular reference to neonicotinoids, which are one of the most widely used pesticides in the world. Mammalian toxicity and hazards posed during insecticide application will be discussed, along with their ecotoxicology, effects on non-target organisms and on the environment. However, toxicity must be balanced by usefulness in crop protection, first in terms of integrated pest management (IPM) and then by detailing national registration processes according to international normative frameworks to achieve the appropriate balance between efficacy and toxicity. Critical in ensuring that this balance is met are controls on pesticides in use, enforcement of pesticide regulations, and food safety measures related insecticide residues and maximum residue limit (MRL) setting. International trade conventions and trade issues are of direct relevance to import and export not only of agricultural products protected by the use of pesticides, but also of the pesticides themselves along with the waste products from their manufacture or use.","PeriodicalId":12128,"journal":{"name":"Fly","volume":"20 1","pages":"2677279"},"PeriodicalIF":1.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13215312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148028764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Driver-independent lexAop-tdTomato.nls reporter signal in the adult Drosophila proventriculus. Driver-independent lexAop-tdTomato。nls报告信号在成年前室果蝇中的表达。

IF 1.4 4区生物学

Fly Pub Date : 2026-12-01 Epub Date: 2026-07-14 DOI: 10.1080/19336934.2026.2699497

Xinyue Zhou, Tianmu Zhang, Woo Jae Kim

{"title":"Driver-independent lexAop-tdTomato.nls reporter signal in the adult Drosophila proventriculus.","authors":"Xinyue Zhou, Tianmu Zhang, Woo Jae Kim","doi":"10.1080/19336934.2026.2699497","DOIUrl":"10.1080/19336934.2026.2699497","url":null,"abstract":"Reporters are widely used in Drosophila genetics to visualize gene expression and cell lineages. However, uncharacterized limitations in specific reporter lines can lead to data misinterpretation. Here, we identify a consistent, driver-independent tdTomato signal in the adult proventriculus from the widely used lexAop-tdTomato.nls reporter line. This signal was observed across multiple lexA driver combinations and was directly detectable in lexAop-tdTomato.nls responder-alone adult proventriculi lacking any lexA driver and without antibody staining. In contrast, no comparable native red fluorescence was detected in larval proventriculi under the same no-antibody imaging condition. Mouse and rabbit anti-RFP immunostaining further supported the presence of proventriculus-associated tdTomato/RFP antigen in adult responder-alone animals. In larval responder-alone proventriculi, antibody-amplified staining was antibody-source-dependent: a detectable signal was observed only with rabbit anti-RFP, whereas mouse and rat anti-RFP produced no reliable detectable signal under the same staining condition. A driver-matched comparison using lexAop-RFP.nls did not reproduce the proventricular signal, arguing against detectable ectopic activity of the tested lexA driver in this tissue. However, because lexAop-tdTomato.nls and lexAop-RFP.nls differ in reporter/transgene architecture and possibly genomic insertion context, the underlying cause cannot be assigned specifically to the lexAop sequence. Our findings highlight the necessity of including driver-negative and no-antibody controls when using this reporter line in adult Drosophila proventriculus and gut studies.","PeriodicalId":12128,"journal":{"name":"Fly","volume":"20 1","pages":"2699497"},"PeriodicalIF":1.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13371488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148435689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of Nora virus in infected Drosophila melanogaster heads without evidence of ubiquitous brain infection by smRNA FISH. 未发现普遍脑感染证据的黑腹果蝇头部诺拉病毒的smRNA FISH检测。

IF 1.4 4区生物学

Fly Pub Date : 2026-12-01 Epub Date: 2026-01-22 DOI: 10.1080/19336934.2026.2620887

Blase Rokusek, Shalie Sklenar, Luke J Hamilton, Sunayn Cheku, Darby J Carlson, Kimberly A Carlson

{"title":"Detection of Nora virus in infected Drosophila melanogaster heads without evidence of ubiquitous brain infection by smRNA FISH.","authors":"Blase Rokusek, Shalie Sklenar, Luke J Hamilton, Sunayn Cheku, Darby J Carlson, Kimberly A Carlson","doi":"10.1080/19336934.2026.2620887","DOIUrl":"10.1080/19336934.2026.2620887","url":null,"abstract":"Drosophila melanogaster Nora virus (DmNV), a positive-sense single stranded RNA virus related to picornaviruses. Given its genetic and structural similarity to neurotropic picornaviruses, such as poliovirus, we sought to determine whether DmNV could be found within the head and brain of D. melanogaster. RNA was extracted from heads of chronically DmNV-infected stocks, as well as from uninfected controls, and assayed using reverse transcription-polymerase chain reaction (RT-PCR) for DmNV open reading frame 1 (ORF1). The results showed that DmNV genomic material can be isolated from the heads of DmNV-infected D. melanogaster, which suggests that the virus reaches the head during the course of infection. To determine whether DmNV infects the brain tissue itself, small-molecule RNA fluorescence in situ hybridization (smRNA FISH) experiments on whole brains dissected from DmNV-infected and uninfected D. melanogaster were done. The smRNA FISH detection method was validated by identifying DmNV RNA in gut tissue, but there was no evidence of DmNV localization in any brain specimens examined. These findings suggest an alternative explanation for why DmNV may be present in dissected head specimens. Additionally, we highlight the effectiveness of smRNA FISH as a highly specific and accessible method for detecting RNA viruses in Drosophila, offering an alternative to antibody-based or transgenic fluorescence approaches. Together, our results refine the understanding of DmNV tissue tropism and provide methodological insights for future studies using insect RNA viruses.","PeriodicalId":12128,"journal":{"name":"Fly","volume":"20 1","pages":"2620887"},"PeriodicalIF":1.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12834166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146028888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insect-based models in pharmaceutical ecotoxicology: a bibliometric and narrative review. 药物生态毒理学中基于昆虫的模型：文献计量学和叙述性回顾。

IF 1.4 4区生物学

Fly Pub Date : 2026-12-01 Epub Date: 2026-06-30 DOI: 10.1080/19336934.2026.2692827

Jumriani Jumriani, Ratnawati Ratnawati, Youdiil Ophinni, Emil Salim, Firzan Nainu

{"title":"Insect-based models in pharmaceutical ecotoxicology: a bibliometric and narrative review.","authors":"Jumriani Jumriani, Ratnawati Ratnawati, Youdiil Ophinni, Emil Salim, Firzan Nainu","doi":"10.1080/19336934.2026.2692827","DOIUrl":"10.1080/19336934.2026.2692827","url":null,"abstract":"Pharmaceutical waste has been recognized as an emerging contaminant that is increasingly detected in the environment and may pose ecotoxicological risks. This review aims to describe the global development of research on pharmaceutical waste within the field of ecotoxicology and to examine the role of insects in trophic food-chain exposure pathways. A bibliometric analysis was conducted using the Scopus database, comprising 1,051 articles published between 2010 and 2025. The results show a consistent upward trend in publications, with pharmaceutical ecotoxicology research predominantly focused on aquatic environments, environmental risk assessment, contaminant monitoring, and toxicological evaluation. Keyword analysis further indicates that terrestrial exposure pathways remain comparatively less emphasized within the current bibliometric landscape. The narrative review indicates that pharmaceutical waste can accumulate in organisms and be transferred through the food chain, leading to various physiological and systemic toxic effects, even at low environmental concentrations. In this context, insects play a strategic role as mediators of trophic exposure. Hermetia illucens is relevant in waste management and biotransformation processes, while Drosophila melanogaster is a well-established model organism for investigating physiological and molecular responses to pharmaceutical compound exposure. Thus, this review discusses the potential of an insect-based ecotoxicology framework in which H. illucens may serve as a bioconversion model for waste processing and D. melanogaster as a mechanistic model for toxicological studies. We also highlight the need for a more integrative ecotoxicological approach to pharmaceutical waste that explicitly considers insect involvement and food chain - based exposure pathways.","PeriodicalId":12128,"journal":{"name":"Fly","volume":"20 1","pages":"2692827"},"PeriodicalIF":1.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13336261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148360072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New cell lines derived from larvae of the neotropical fruit fly Drosophila willistoni persistently infected with Wolbachia. 从持续感染沃尔巴克氏体的新热带果蝇（Drosophila willistoni）幼虫中获得的新细胞系。

IF 1.4 4区生物学

Fly Pub Date : 2026-12-01 Epub Date: 2026-06-22 DOI: 10.1080/19336934.2026.2690767

Lesley Bell-Sakyi, Elina Koivisto, Anton Strunov, Catherine Hartley, Jing Jing Khoo, Ewa Chrostek, Aurélie Hua-Van, Benjamin L Makepeace, Wolfgang J Miller

{"title":"New cell lines derived from larvae of the neotropical fruit fly Drosophila willistoni persistently infected with Wolbachia.","authors":"Lesley Bell-Sakyi, Elina Koivisto, Anton Strunov, Catherine Hartley, Jing Jing Khoo, Ewa Chrostek, Aurélie Hua-Van, Benjamin L Makepeace, Wolfgang J Miller","doi":"10.1080/19336934.2026.2690767","DOIUrl":"10.1080/19336934.2026.2690767","url":null,"abstract":"Although several hundred continuous cell lines have been generated from Drosophila spp. fruit flies over the past half-century, nearly all are derived from a single species, Drosophila melanogaster, and none are derived from neotropical flies. To address this deficit, a simplified protocol was used to generate three primary cell cultures from larvae of Drosophila willistoni originating from Costa Rica. All three primary cultures developed into continuous cell lines, and all three cell lines, designated DWL/LULS68, DWL/LULS70 and DWL/LULS72, were found to be persistently infected with the bacterial endosymbiont Wolbachia. Sublines free of Wolbachia were generated from all three cell lines by prolonged tetracycline treatment. Molecular analysis, karyotyping and fluorescence in situ hybridization confirmed species origin of the cells as D. willistoni and identified the Wolbachia as the strain wWil. Wolbachia wWil was successfully transferred from D. willistoni cells to heterologous cell lines derived from the sand fly Lutzomyia longipalpis, the biting midge Culicoides sonorensis and the tsetse fly Glossina morsitans, but not to cell lines derived from ticks or triatomine bugs. The new D. willistoni cell lines are expected to facilitate many aspects of research into this species and its bacterial symbionts.","PeriodicalId":12128,"journal":{"name":"Fly","volume":"20 1","pages":"2690767"},"PeriodicalIF":1.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13313235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond pesticides: next-generation genetic biocontrol technologies for sustainable population suppression of agricultural insect pests. 超越农药：可持续种群抑制农业害虫的下一代遗传生物防治技术。

IF 1.4 4区生物学

Fly Pub Date : 2026-12-01 Epub Date: 2026-06-17 DOI: 10.1080/19336934.2026.2682509

Eddie Hill, Robyn Raban, Omar S Akbari

{"title":"Beyond pesticides: next-generation genetic biocontrol technologies for sustainable population suppression of agricultural insect pests.","authors":"Eddie Hill, Robyn Raban, Omar S Akbari","doi":"10.1080/19336934.2026.2682509","DOIUrl":"10.1080/19336934.2026.2682509","url":null,"abstract":"Chemical insecticides have long been used to control agricultural pests, but their widespread application has driven resistance and caused significant ecological and health impacts. CRISPR/Cas9-based genetic biocontrol technologies, including the precision-guided sterile insect technique (pgSIT) and homing gene drives (HGDs), offer targeted alternatives for suppressing pest populations with reduced environmental cost. pgSIT produces sterile males without radiation and achieves high mating competitiveness without multigenerational persistence. In contrast, HGDs bias inheritance to enable sustained population suppression through disruption of essential fertility or viability genes, albeit with greater ecological and regulatory considerations. Experimental applications in multiple agricultural pest species demonstrate robust suppression efficacy. Emerging innovations, including temperature-inducible pgSIT systems, may further streamline mass-rearing and deployment. Together, these approaches have the potential to reduce crop losses and reliance on chemical insecticides while lowering long-term management costs. Their successful integration into agricultural systems will depend on rigorous risk assessment, regulatory oversight, and stakeholder engagement.","PeriodicalId":12128,"journal":{"name":"Fly","volume":"20 1","pages":"2682509"},"PeriodicalIF":1.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Loss of Drosophila UBE3A phenocopies Piezo dysfunction and drives hyperphagic feeding in Drosophila. 果蝇UBE3A表型的缺失导致果蝇压电功能障碍并驱动贪食。

IF 1.4 4区生物学

Fly Pub Date : 2026-12-01 Epub Date: 2026-01-16 DOI: 10.1080/19336934.2026.2616950

Benjamin Geier, Logan Neely, Eli Coronado, Lawrence T Reiter

{"title":"Loss of Drosophila UBE3A phenocopies Piezo dysfunction and drives hyperphagic feeding in Drosophila.","authors":"Benjamin Geier, Logan Neely, Eli Coronado, Lawrence T Reiter","doi":"10.1080/19336934.2026.2616950","DOIUrl":"10.1080/19336934.2026.2616950","url":null,"abstract":"Angelman syndrome (AS) is a rare neurogenetic disorder characterized by developmental delay, speech impairment, ataxia, epilepsy, and in some cases hyperphagic feeding behavior. AS is caused by loss of function mutations, loss of expression, or maternal allele deletion of the E3 ubiquitin ligase UBE3A. Recent work has identified a connection between UBE3A and the mechanosensitive ion channel PIEZO2, raising the possibility that UBE3A may regulate PIEZO-dependent satiety signaling. In this study, we investigated the role of the Drosophila UBE3A ortholog, Dube3a, in Piezo-associated feeding behaviors. Single-cell RNA-sequencing data revealed overlapping expression of Dube3a and Piezo within crop and enterocyte populations of the gut, identifying a relevant cellular context for this pathway to occur. We developed a novel feeding assay using GFP-expressing yeast to quantify food intake and gut distention in vivo. Dube3a loss-of-function (Dube3a15b) flies exhibited hyperphagia and gut distention nearly identical to Piezo knockout flies. Analysis of chromosomal deficiency lines spanning the Dube3a locus further supported a requirement for Dube3a in normal satiety signaling. Finally, biochemical analyses demonstrated that Dube3a knockdown results in decreased Piezo protein levels, consistent with an indirect regulatory relationship. Together, these findings identify Dube3a as a critical regulator of Piezo-dependent satiety pathways and suggest that dysregulation of mechanosensory signaling may contribute to hyperphagia observed in AS. Further work is needed to define the intermediate factors linking UBE3A activity to Piezo stability and function.","PeriodicalId":12128,"journal":{"name":"Fly","volume":"20 1","pages":"2616950"},"PeriodicalIF":1.4,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12818797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145988932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0