IF 1.2 4区生物学

Fly Pub Date : 2017-10-02 Epub Date: 2017-04-20 DOI: 10.1080/19336934.2017.1321181

Michaelyn A Hartmann, Jeff Sekelsky

引用次数: 13

The dark side of hippo signaling: A cancer promoter role. 河马信号的阴暗面:癌症启动子的作用。

IF 1.2 4区生物学

Fly Pub Date : 2017-10-02 Epub Date: 2017-06-02 DOI: 10.1080/19336934.2017.1336270

Brandon Dunn, Xianjue Ma

{"title":"The dark side of hippo signaling: A cancer promoter role.","authors":"Brandon Dunn, Xianjue Ma","doi":"10.1080/19336934.2017.1336270","DOIUrl":"https://doi.org/10.1080/19336934.2017.1336270","url":null,"abstract":"The Hippo signaling pathway regulates organ size and tissue homeostasis. Given this role it is unsurprising that dysregulation of this pathway has implications for cancer progression. A convincing body of literature shows that the Hippo pathway serves a tumor suppressive function with its inactivation leading to massive overgrowth. However, additional studies have also shown that activation of Hippo signaling can promote tumor progression. It remains unknown how a single pathway can produce such diametrically opposed effects. This lack of knowledge is in part due to our inability to make meaningful comparisons from studies which have taken place in a variety of cell types, tissues, and organisms. Recently however, we have published 2 studies using the Drosophila wing disk to study the Hippo pathway and have found that Hippo pathway activation can promote cell migration and invasion while Hippo pathway inactivation leads to overgrowth. Thus we propose here that Drosophila can provide a research platform with which to begin addressing how the Hippo pathway can both enhance and suppress tumor progression due to published pro- and anti-tumor functionalities of the Hippo pathway in the same tissue.","PeriodicalId":12128,"journal":{"name":"Fly","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2017-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336934.2017.1336270","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35054696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Genomic signatures of local adaptation in the Drosophila immune response. 果蝇免疫应答中局部适应的基因组特征。

IF 1.2 4区生物学

Fly Pub Date : 2017-10-02 Epub Date: 2017-06-06 DOI: 10.1080/19336934.2017.1337612

Angela M Early, Andrew G Clark

{"title":"Genomic signatures of local adaptation in the Drosophila immune response.","authors":"Angela M Early, Andrew G Clark","doi":"10.1080/19336934.2017.1337612","DOIUrl":"https://doi.org/10.1080/19336934.2017.1337612","url":null,"abstract":"As environments and pathogen landscapes shift, host defenses must evolve to remain effective. Due to this selection pressure, among-species comparisons of genetic sequence data often find immune genes to be among the fastest evolving genes across the genome. The full extent and nature of these immune adaptations, however, remain largely unexplored. In a recent study, we analyzed patterns of selection within distinct components of the Drosophila melanogaster immune pathway. While we found evidence of positive selection within some immune processes, immune genes were not universally characterized by signatures of strong selection. On the contrary, we even found that some immune functions show greater than expected constraint. Overall these results highlight 2 major factors that appear to play an outsize role in determining a gene's evolutionary rate: the type of pathogen the gene targets and the gene's position within the immune network. These results join a growing body of literature that highlight the complexity of immune adaptation. Rather than there being uniformly strong selection across all immune genes, a combination of pathogen-specificity and host genetic constraints appear to play key roles in determining each immune gene's individual evolutionary trajectory.","PeriodicalId":12128,"journal":{"name":"Fly","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2017-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336934.2017.1337612","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35064606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Complex roles of myoglianin in regulating adult performance and lifespan. 肌球蛋白在调节成人运动能力和寿命中的复杂作用。

IF 1.2 4区生物学

Fly Pub Date : 2017-10-02 Epub Date: 2017-08-24 DOI: 10.1080/19336934.2017.1369638

Hrvoje Augustin, Jennifer Adcott, Christopher J H Elliott, Linda Partridge

引用次数: 8

New perspectives on the roles of Abl tyrosine kinase in axon patterning. Abl酪氨酸激酶在轴突模式中作用的新观点。

IF 1.2 4区生物学

Fly Pub Date : 2017-10-02 Epub Date: 2017-05-08 DOI: 10.1080/19336934.2017.1327106

Ramakrishnan Kannan, Edward Giniger

{"title":"New perspectives on the roles of Abl tyrosine kinase in axon patterning.","authors":"Ramakrishnan Kannan, Edward Giniger","doi":"10.1080/19336934.2017.1327106","DOIUrl":"https://doi.org/10.1080/19336934.2017.1327106","url":null,"abstract":"The Abelson tyrosine kinase (Abl) lies at the heart of one of the small set of ubiquitous, conserved signal transduction pathways that do much of the work of development and physiology. Abl signaling is essential to epithelial integrity, motility of autonomous cells such as blood cells, and axon growth and guidance in the nervous system. However, though Abl was one of the first of these conserved signaling machines to be identified, it has been among the last to have its essential architecture elucidated. Here we will first discuss some of the challenges that long delayed the dissection of this pathway, and what they tell us about the special problems of investigating dynamic processes like motility. We will then describe our recent experiments that revealed the functional organization of the Abl pathway in Drosophila neurons. Finally, in the second part of the review we will introduce a different kind of complexity in the role of Abl in motility: the discovery of a previously unappreciated function in protein secretion and trafficking. We will provide evidence that the secretory function of Abl also contributes to its role in axon growth and guidance, and finally end with a discussion of the challenges that Abl pleiotropy provide for the investigator, but the opportunities that it provides for coordinating biological regulation.","PeriodicalId":12128,"journal":{"name":"Fly","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2017-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336934.2017.1327106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34975999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Control of protein translation by IP₃R-mediated Ca²⁺ release in Drosophila neuroendocrine cells. 果蝇神经内分泌细胞中 IP3R 介导的 Ca2+ 释放对蛋白质翻译的控制

IF 1.2 4区生物学

Fly Pub Date : 2017-09-26 DOI: 10.1080/19336934.2017.1384103

Megha, Gaiti Hasan

引用次数: 0

Methods to investigate the structure and connectivity of the nervous system. 方法:研究神经系统的结构和连通性。

IF 1.2 4区生物学

Fly Pub Date : 2017-07-03 Epub Date: 2017-02-16 DOI: 10.1080/19336934.2017.1295189

Donghyung Lee, Ting-Hao Huang, Aubrie De La Cruz, Antuca Callejas, Carlos Lois

引用次数: 12

Gene expression and morphogenesis during the deposition of Drosophila wing cuticle. 果蝇翅膀角质层沉积过程中的基因表达与形态发生。

IF 1.2 4区生物学

Fly Pub Date : 2017-07-03 Epub Date: 2017-02-17 DOI: 10.1080/19336934.2017.1295188

Paul N Adler

引用次数: 2

Drosophila development, physiology, behavior, and lifespan are influenced by altered dietary composition. 果蝇的发育、生理、行为和寿命受到饮食组成改变的影响。

IF 1.2 4区生物学

Fly Pub Date : 2017-07-03 Epub Date: 2017-03-09 DOI: 10.1080/19336934.2017.1304331

Kiel G Ormerod, Olivia K LePine, Prabhodh S Abbineni, Justin M Bridgeman, Jens R Coorssen, A Joffre Mercier, Glenn J Tattersall

{"title":"Drosophila development, physiology, behavior, and lifespan are influenced by altered dietary composition.","authors":"Kiel G Ormerod, Olivia K LePine, Prabhodh S Abbineni, Justin M Bridgeman, Jens R Coorssen, A Joffre Mercier, Glenn J Tattersall","doi":"10.1080/19336934.2017.1304331","DOIUrl":"https://doi.org/10.1080/19336934.2017.1304331","url":null,"abstract":"Diet profoundly influences the behavior of animals across many phyla. Despite this, most laboratories using model organisms, such as Drosophila, use multiple, different, commercial or custom-made media for rearing their animals. In addition to measuring growth, fecundity and longevity, we used several behavioral and physiological assays to determine if and how altering food media influence wild-type (Canton S) Drosophila melanogaster, at larval, pupal, and adult stages. Comparing 2 commonly used commercial food media we observed several key developmental and morphological differences. Third-instar larvae and pupae developmental timing, body weight and size, and even lifespan significantly differed between the 2 diets, and some of these differences persisted into adulthood. Diet was also found to produce significantly different thermal preference, locomotory capacity for geotaxis, feeding rates, and lower muscle response to hormonal stimulation. There were no differences, however, in adult thermal preferences, in the number or viability of eggs laid, or in olfactory learning and memory between the diets. We characterized the composition of the 2 diets and found particularly significant differences in cholesterol and (phospho)lipids between them. Notably, diacylglycerol (DAG) concentrations vary substantially between the 2 diets, and may contribute to key phenotypic differences, including lifespan. Overall, the data confirm that 2 different diets can profoundly influence the behavior, physiology, morphology and development of wild-type Drosophila, with greater behavioral and physiologic differences occurring during the larval stages.","PeriodicalId":12128,"journal":{"name":"Fly","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2017-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336934.2017.1304331","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34798640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Ovarian ecdysteroid biosynthesis and female germline stem cells. 卵巢外甾体生物合成与女性生殖系干细胞。

IF 1.2 4区生物学

Fly Pub Date : 2017-07-03 Epub Date: 2017-02-08 DOI: 10.1080/19336934.2017.1291472

Tomotsune Ameku, Yuto Yoshinari, Ruriko Fukuda, Ryusuke Niwa

引用次数: 30

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