IF 1.2 4区生物学

Fly Pub Date : 2018-01-01 Epub Date: 2018-08-21 DOI: 10.1080/19336934.2018.1502535

Annick Sawala, Alex P Gould

{"title":"Sex-lethal in neurons controls female body growth in Drosophila.","authors":"Annick Sawala, Alex P Gould","doi":"10.1080/19336934.2018.1502535","DOIUrl":"https://doi.org/10.1080/19336934.2018.1502535","url":null,"abstract":"Sexual size dimorphism (SSD), a sex difference in body size, is widespread throughout the animal kingdom, raising the question of how sex influences existing growth regulatory pathways to bring about SSD. In insects, somatic sexual differentiation has long been considered to be controlled strictly cell-autonomously. Here, we discuss our surprising finding that in Drosophila larvae, the sex determination gene Sex-lethal (Sxl) functions in neurons to non-autonomously specify SSD. We found that Sxl is required in specific neuronal subsets to upregulate female body growth, including in the neurosecretory insulin producing cells, even though insulin-like peptides themselves appear not to be involved. SSD regulation by neuronal Sxl is also independent of its known splicing targets, transformer and msl-2, suggesting that it involves a new molecular mechanism. Interestingly, SSD control by neuronal Sxl is selective for larval, not imaginal tissue types, and operates in addition to cell-autonomous effects of Sxl and Tra, which are present in both larval and imaginal tissues. Overall, our findings add to a small but growing number of studies reporting non-autonomous, likely hormonal, control of sex differences in Drosophila, and suggest that the principles of sexual differentiation in insects and mammals may be more similar than previously thought.","PeriodicalId":12128,"journal":{"name":"Fly","volume":"12 2","pages":"133-141"},"PeriodicalIF":1.2,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336934.2018.1502535","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36411248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Generation of genome-modified Drosophila cell lines using SwAP. 利用SwAP产生基因组修饰的果蝇细胞系。

IF 1.2 4区生物学

Fly Pub Date : 2017-10-02 Epub Date: 2017-08-30 DOI: 10.1080/19336934.2017.1372068

Alexandra Franz, Erich Brunner, Konrad Basler

引用次数: 5

Dual role of BMP signaling in the regulation of Drosophila intestinal stem cell self-renewal. BMP信号在果蝇肠道干细胞自我更新调控中的双重作用。

IF 1.2 4区生物学

Fly Pub Date : 2017-10-02 Epub Date: 2017-09-25 DOI: 10.1080/19336934.2017.1384104

Aiguo Tian, Jin Jiang

{"title":"Dual role of BMP signaling in the regulation of Drosophila intestinal stem cell self-renewal.","authors":"Aiguo Tian, Jin Jiang","doi":"10.1080/19336934.2017.1384104","DOIUrl":"https://doi.org/10.1080/19336934.2017.1384104","url":null,"abstract":"Many adult organs including Drosophila adult midguts rely on resident stem cells to replenish damaged cells during tissue homeostasis and regeneration. Previous studies have shown that, upon injury, intestinal stem cells (ISCs) in the midguts can increase proliferation and lineage differentiation to meet the demand for tissue repair. Our recent study has demonstrated that, in response to certain injury, midguts can expand ISC population size as an additional regenerative mechanism. We found that injury elicited by bleomycin feeding or bacterial infection increased the production of two BMP ligands (Dpp and Gbb) in enterocytes (ECs), leading to elevated BMP signaling in progenitor cells that drove an expansion of ISCs by promoting their symmetric self-renewing division. Interestingly, we also found that BMP signaling in ECs inhibits the production of Dpp and Gbb, and that this negative feedback mechanism is required to reset ISC pool size to the homeostatic state. Our findings suggest that BMP signaling exerts two opposing influences on stem cell activity depending on where it acts: BMP signaling in progenitor cells promotes ISC self-renewal while BMP signaling in ECs restricts ISC self-renewal by preventing excessive production of BMP ligands. Our results further suggest that transient expansion of ISC population in conjunction with increasing ISC proliferation provides a more effective strategy for tissue regeneration.","PeriodicalId":12128,"journal":{"name":"Fly","volume":"11 4","pages":"297-302"},"PeriodicalIF":1.2,"publicationDate":"2017-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336934.2017.1384104","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35441060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Comparative analysis of behavioral and transcriptional variation underlying CO₂ sensory neuron function and development in Drosophila. 果蝇二氧化碳感觉神经元功能和发育的行为和转录变异的比较分析。

IF 1.2 4区生物学

Fly Pub Date : 2017-10-02 Epub Date: 2017-06-23 DOI: 10.1080/19336934.2017.1344374

Jia Wern Pan, Joi McLaughlin, Haining Yang, Charles Leo, Paula Rambarat, Sumie Okuwa, Anaïs Monroy-Eklund, Sabrina Clark, Corbin D Jones, Pelin Cayirlioglu Volkan

{"title":"Comparative analysis of behavioral and transcriptional variation underlying CO2 sensory neuron function and development in Drosophila.","authors":"Jia Wern Pan, Joi McLaughlin, Haining Yang, Charles Leo, Paula Rambarat, Sumie Okuwa, Anaïs Monroy-Eklund, Sabrina Clark, Corbin D Jones, Pelin Cayirlioglu Volkan","doi":"10.1080/19336934.2017.1344374","DOIUrl":"https://doi.org/10.1080/19336934.2017.1344374","url":null,"abstract":"Carbon dioxide is an important environmental cue for many insects, regulating many behaviors including some that have direct human impacts. To further improve our understanding of how this system varies among closely related insect species, we examined both the behavioral response to CO2 as well as the transcriptional profile of key developmental regulators of CO2 sensory neurons in the olfactory system across the Drosophila genus. We found that CO2 generally evokes repulsive behavior across most of the Drosophilids we examined, but this behavior has been lost or reduced in several lineages. Comparisons of transcriptional profiles from the developing and adult antennae for subset these species suggest that behavioral differences in some species may be due to differences in the expression of the CO2 co-receptor Gr63a. Furthermore, these differences in Gr63a expression are correlated with changes in the expression of a few genes known to be involved in the development of the CO2 circuit, namely dac, an important regulator of sensilla fate for sensilla that house CO2 ORNs, and mip120, a member of the MMB/dREAM epigenetic regulatory complex that regulates CO2 receptor expression. In contrast, most of the other known structural, molecular, and developmental components of the peripheral Drosophila CO2 olfactory system seem to be well-conserved across all examined lineages. These findings suggest that certain components of CO2 sensory ORN development may be more evolutionarily labile, and may contribute to differences in CO2-evoked behavioral responses across species.","PeriodicalId":12128,"journal":{"name":"Fly","volume":"11 4","pages":"239-252"},"PeriodicalIF":1.2,"publicationDate":"2017-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336934.2017.1344374","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35114722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The absence of crossovers on chromosome 4 in Drosophila melanogaster: Imperfection or interesting exception? 黑腹果蝇4号染色体无交叉:缺陷还是有趣的例外?

IF 1.2 4区生物学

Fly Pub Date : 2017-10-02 Epub Date: 2017-04-20 DOI: 10.1080/19336934.2017.1321181

Michaelyn A Hartmann, Jeff Sekelsky

引用次数: 13

Complex roles of myoglianin in regulating adult performance and lifespan. 肌球蛋白在调节成人运动能力和寿命中的复杂作用。

IF 1.2 4区生物学

Fly Pub Date : 2017-10-02 Epub Date: 2017-08-24 DOI: 10.1080/19336934.2017.1369638

Hrvoje Augustin, Jennifer Adcott, Christopher J H Elliott, Linda Partridge

引用次数: 8

The dark side of hippo signaling: A cancer promoter role. 河马信号的阴暗面:癌症启动子的作用。

IF 1.2 4区生物学

Fly Pub Date : 2017-10-02 Epub Date: 2017-06-02 DOI: 10.1080/19336934.2017.1336270

Brandon Dunn, Xianjue Ma

{"title":"The dark side of hippo signaling: A cancer promoter role.","authors":"Brandon Dunn, Xianjue Ma","doi":"10.1080/19336934.2017.1336270","DOIUrl":"https://doi.org/10.1080/19336934.2017.1336270","url":null,"abstract":"The Hippo signaling pathway regulates organ size and tissue homeostasis. Given this role it is unsurprising that dysregulation of this pathway has implications for cancer progression. A convincing body of literature shows that the Hippo pathway serves a tumor suppressive function with its inactivation leading to massive overgrowth. However, additional studies have also shown that activation of Hippo signaling can promote tumor progression. It remains unknown how a single pathway can produce such diametrically opposed effects. This lack of knowledge is in part due to our inability to make meaningful comparisons from studies which have taken place in a variety of cell types, tissues, and organisms. Recently however, we have published 2 studies using the Drosophila wing disk to study the Hippo pathway and have found that Hippo pathway activation can promote cell migration and invasion while Hippo pathway inactivation leads to overgrowth. Thus we propose here that Drosophila can provide a research platform with which to begin addressing how the Hippo pathway can both enhance and suppress tumor progression due to published pro- and anti-tumor functionalities of the Hippo pathway in the same tissue.","PeriodicalId":12128,"journal":{"name":"Fly","volume":"11 4","pages":"271-276"},"PeriodicalIF":1.2,"publicationDate":"2017-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336934.2017.1336270","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35054696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Genomic signatures of local adaptation in the Drosophila immune response. 果蝇免疫应答中局部适应的基因组特征。

IF 1.2 4区生物学

Fly Pub Date : 2017-10-02 Epub Date: 2017-06-06 DOI: 10.1080/19336934.2017.1337612

Angela M Early, Andrew G Clark

{"title":"Genomic signatures of local adaptation in the Drosophila immune response.","authors":"Angela M Early, Andrew G Clark","doi":"10.1080/19336934.2017.1337612","DOIUrl":"https://doi.org/10.1080/19336934.2017.1337612","url":null,"abstract":"As environments and pathogen landscapes shift, host defenses must evolve to remain effective. Due to this selection pressure, among-species comparisons of genetic sequence data often find immune genes to be among the fastest evolving genes across the genome. The full extent and nature of these immune adaptations, however, remain largely unexplored. In a recent study, we analyzed patterns of selection within distinct components of the Drosophila melanogaster immune pathway. While we found evidence of positive selection within some immune processes, immune genes were not universally characterized by signatures of strong selection. On the contrary, we even found that some immune functions show greater than expected constraint. Overall these results highlight 2 major factors that appear to play an outsize role in determining a gene's evolutionary rate: the type of pathogen the gene targets and the gene's position within the immune network. These results join a growing body of literature that highlight the complexity of immune adaptation. Rather than there being uniformly strong selection across all immune genes, a combination of pathogen-specificity and host genetic constraints appear to play key roles in determining each immune gene's individual evolutionary trajectory.","PeriodicalId":12128,"journal":{"name":"Fly","volume":"11 4","pages":"277-283"},"PeriodicalIF":1.2,"publicationDate":"2017-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336934.2017.1337612","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35064606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

New perspectives on the roles of Abl tyrosine kinase in axon patterning. Abl酪氨酸激酶在轴突模式中作用的新观点。

IF 1.2 4区生物学

Fly Pub Date : 2017-10-02 Epub Date: 2017-05-08 DOI: 10.1080/19336934.2017.1327106

Ramakrishnan Kannan, Edward Giniger

{"title":"New perspectives on the roles of Abl tyrosine kinase in axon patterning.","authors":"Ramakrishnan Kannan, Edward Giniger","doi":"10.1080/19336934.2017.1327106","DOIUrl":"https://doi.org/10.1080/19336934.2017.1327106","url":null,"abstract":"The Abelson tyrosine kinase (Abl) lies at the heart of one of the small set of ubiquitous, conserved signal transduction pathways that do much of the work of development and physiology. Abl signaling is essential to epithelial integrity, motility of autonomous cells such as blood cells, and axon growth and guidance in the nervous system. However, though Abl was one of the first of these conserved signaling machines to be identified, it has been among the last to have its essential architecture elucidated. Here we will first discuss some of the challenges that long delayed the dissection of this pathway, and what they tell us about the special problems of investigating dynamic processes like motility. We will then describe our recent experiments that revealed the functional organization of the Abl pathway in Drosophila neurons. Finally, in the second part of the review we will introduce a different kind of complexity in the role of Abl in motility: the discovery of a previously unappreciated function in protein secretion and trafficking. We will provide evidence that the secretory function of Abl also contributes to its role in axon growth and guidance, and finally end with a discussion of the challenges that Abl pleiotropy provide for the investigator, but the opportunities that it provides for coordinating biological regulation.","PeriodicalId":12128,"journal":{"name":"Fly","volume":"11 4","pages":"260-270"},"PeriodicalIF":1.2,"publicationDate":"2017-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/19336934.2017.1327106","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34975999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Control of protein translation by IP₃R-mediated Ca²⁺ release in Drosophila neuroendocrine cells. 果蝇神经内分泌细胞中 IP3R 介导的 Ca2+ 释放对蛋白质翻译的控制

IF 1.2 4区生物学

Fly Pub Date : 2017-09-26 DOI: 10.1080/19336934.2017.1384103

Megha, Gaiti Hasan

引用次数: 0

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