黑腹果蝇4号染色体无交叉:缺陷还是有趣的例外?

IF 2.4 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Fly Pub Date : 2017-10-02 Epub Date: 2017-04-20 DOI:10.1080/19336934.2017.1321181

Michaelyn A Hartmann, Jeff Sekelsky

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引用次数: 13

摘要

黑腹果蝇4号染色体是一种异常染色体，因为它的尺寸小，染色质结构，最明显的是它在减数分裂期间缺乏杂交。早先关于4上没有交叉的想法假设这些独特的特征起着防止交叉的作用。在这里，我们探讨了关于4号上没有交叉的假设，这些假设是如何解决的，以及对这种抑制背后机制的新见解。我们回顾了最近发表的结果，表明全球交叉模式，特别是着丝粒效应，对4号染色体交叉的预防做出了重大贡献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The absence of crossovers on chromosome 4 in Drosophila melanogaster: Imperfection or interesting exception?

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The absence of crossovers on chromosome 4 in Drosophila melanogaster: Imperfection or interesting exception?

Drosophila melanogaster chromosome 4 is an anomaly because of its small size, chromatin structure, and most notably its lack of crossing over during meiosis. Earlier ideas about the absence of crossovers on 4 hypothesize that these unique characteristics function to prevent crossovers. Here, we explore hypotheses about the absence of crossovers on 4, how these have been addressed, and new insights into the mechanism behind this suppression. We review recently published results that indicate that global crossover patterning, in particular the centromere effect, make a major contribution to the prevention of crossovers on 4.

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来源期刊

Fly 生物-生化与分子生物学

CiteScore

2.90

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Fly is the first international peer-reviewed journal to focus on Drosophila research. Fly covers a broad range of biological sub-disciplines, ranging from developmental biology and organogenesis to sensory neurobiology, circadian rhythm and learning and memory, to sex determination, evolutionary biology and speciation. We strive to become the “to go” resource for every researcher working with Drosophila by providing a forum where the specific interests of the Drosophila community can be discussed. With the advance of molecular technologies that enable researchers to manipulate genes and their functions in many other organisms, Fly is now also publishing papers that use other insect model systems used to investigate important biological questions. Fly offers a variety of papers, including Original Research Articles, Methods and Technical Advances, Brief Communications, Reviews and Meeting Reports. In addition, Fly also features two unconventional types of contributions, Counterpoints and Extra View articles. Counterpoints are opinion pieces that critically discuss controversial papers questioning current paradigms, whether justified or not. Extra View articles, which generally are solicited by Fly editors, provide authors of important forthcoming papers published elsewhere an opportunity to expand on their original findings and discuss the broader impact of their discovery. Extra View authors are strongly encouraged to complement their published observations with additional data not included in the original paper or acquired subsequently.