Eye最新文献

{"title":"Comment on: \"Benchmarking the performance of large language models in uveitis: a comparative analysis of ChatGPT-3.5, ChatGPT-4.0, Google Gemini, and Anthropic Claude3\".","authors":"Xiao Luo, Cheng Tang, Jin-Jin Chen, Jin Yuan, Jin-Jin Huang, Tao Yan","doi":"10.1038/s41433-025-03736-y","DOIUrl":"10.1038/s41433-025-03736-y","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1432"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043941/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-cohort analysis identifying core ocular surface microbiome and bacterial alterations in eye diseases.","authors":"Xiangtian Ling, Xiu Juan Zhang, Christine H T Bui, Hei Nga Chan, Jennifer Wing Ki Yau, Fang Yao Tang, Ka Wai Kam, Patrick Ip, Alvin L Young, Kam Lun Hon, Clement C Tham, Chi Pui Pang, Li Jia Chen, Jason C Yam","doi":"10.1038/s41433-024-03589-x","DOIUrl":"10.1038/s41433-024-03589-x","url":null,"abstract":"<p><strong>Purpose: </strong>Inconsistency exists among reported studies on the composition of human ocular surface microbiome (OSM). The roles of OSM in ocular diseases remain uncertain. In this study, we aimed to determine the composition of OSM and to evaluate its potential roles and functions from multiple cohorts.</p><p><strong>Methods: </strong>Raw 16 s sequencing data were obtainable from publicly available repositories, sourced from 17 published studies. Employing a standardized method, we processed the data and conducted a cross-cohort analysis. Through bioinformatics pipelines QIIME2 and PICRUSt2, we processed a total of 1875 ocular surface samples. Core microbiome analyses, genera comparisons, and MetaCyc pathway analyses were performed within each cohort independently. The results were then combined to identify shared patterns across different datasets.</p><p><strong>Results: </strong>The core OSM comprised seven genera: Corynebacterium, Staphylococcus, Acinetobacter, Streptococcus, Pseudomonas, Cutibacterium and Bacillus. Corynebacterium and Staphylococcus are the most abundant genera on ocular surface. Most ocular diseases showed OSM alterations and eight genera demonstrated a non-specific, shared response among two or more ocular diseases. Moreover, changes in various metabolic pathways were predicted following OSM alteration, indicating potential roles of OSM in biological processes.</p><p><strong>Conclusion: </strong>We refined the core OSM candidates combining multiple cohorts. The common pattern shared by different cohorts is worth further investigation. Changes in metabolic pathways based on bioinformatic analysis indicated a role of OSM on ocular diseases. Our results help extend the knowledge and encourage further investigations on the associations between OSM and ocular diseases.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1276-1285"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044048/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: UK corneal surgeons' attitudes towards splitting donor corneas between multiple recipients.","authors":"Jamie A Yule, Virginija Vilkelyte, Shakeel Ahmad, Poonam Sharma, James Myerscough, Stephen Kaye, Harry W Roberts","doi":"10.1038/s41433-025-03695-4","DOIUrl":"10.1038/s41433-025-03695-4","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1434-1435"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related macular degeneration in 2025- opportunities and challenges.","authors":"Chui Ming Gemmy Cheung","doi":"10.1038/s41433-025-03710-8","DOIUrl":"10.1038/s41433-025-03710-8","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1231-1232"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subtypes of primary angle closure disease based on age-independent anterior segment optical coherence tomography parameters.","authors":"Ruthra Umapathi, Marco Yu, Ching-Yu Cheng, Raymond P Najjar, Rahat Husain, Ching Lin Ho, Tina T Wong, Pui Yi Boey, Shamira Perera, Eranga N Vithana, Tin Aung, Monisha E Nongpiur","doi":"10.1038/s41433-025-03597-5","DOIUrl":"10.1038/s41433-025-03597-5","url":null,"abstract":"<p><strong>Objective: </strong>To identify subgroups of angle closure disease by considering age-independent anterior segment parameters.</p><p><strong>Methods: </strong>Anterior-segment optical coherence tomography (ASOCT) was performed in primary angle closure suspect (PACS) and primary angle closure glaucoma (PACG) patients. Clustering analysis using age-independent parameters, anterior chamber width (ACW), anterior vault (AV), posterior corneal arc length (PCAL), and iris area was performed. The optimum number of subgroups was determined using Bayesian Information Criterion and subjects were classified into subgroups by Gaussian Mixture Model methods.</p><p><strong>Results: </strong>A total of 650 PACS and 411 PACG were analysed. The optimal number of subgroups of the combined PACS and PACG dataset was 3. Subgroup 1 (n = 186, 29.3%) has the largest anterior chamber dimension with large AV and total anterior chamber area, subgroup 2 (n = 16, 2.5%) has the widest ACW and shallowest anterior chamber depth (ACD), and subgroup 3 (n = 432; 68.1%) has large iris area with the smallest anterior chamber dimensions, characterised by a small ACW, AV, and PCAL. Subgroup 3 comprised a significantly greater proportion of PACG compared to PACS (74.2% vs 64.6%, p = 0.04) while subgroup 1 had the greatest proportion of PACS ≥ 70 years old, yet to have progressed to PACG.</p><p><strong>Conclusion: </strong>We identified 3 subgroups of angle closure eyes, each characterised by distinct structural components based on ASOCT. A greater proportion of older PACS yet to have progressed to PACG belonging to the subgroup with the largest anterior chamber dimensions suggests that a more spacious anterior chamber may be associated with PACS that remains stable.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1384-1389"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in eye axis length and corneal curvature in central China from the perspective of birth year.","authors":"Lufan Li, Nan Zhang, Xiaoqin Wang, Qingsong Wu, Rui Li, Rong Huang, Lan Yu, Yang Liu, Xiaomin Chen, Weijuan Zeng, Yixin Hu, Fang Li, Wenjing Li, Yue Fu, Bin Jiang, Liang Liang, Min Ke","doi":"10.1038/s41433-025-03652-1","DOIUrl":"10.1038/s41433-025-03652-1","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the changes in eye structures over time in the Chinese population from the perspective of birth year.</p><p><strong>Methods: </strong>We collected measurement data of intraocular lens Master from patients who underwent intraocular lens Master biometry for a routine cataract or refractive examination (ametropia and presbyopia) between April 2012 and October 2023, then screened them. Selected patients were divided into ten groups of 10 years each according to their year of birth (called birth decades). Birth-year-dependent changes in axial length and corneal curvature were compared between the groups.</p><p><strong>Results: </strong>The average axial length increased from 23.52 mm to 25.95 mm, and the corneal curvature dropped from 44.20 D to 43.33 D in patients born in before-1930 and 1990s. The proportion of short average axial length and steep corneal curvature decreased, whereas the proportion of long average axial length increased with the birth decade. The proportion of patients with corneal curvature < 40 D was 4.18% in 1970s, 5.73% in 1980s, and 3.38% in 1990s, which were significantly higher than those of other age groups. The average axial length of the eyes among primary school students was 23.96 mm, and among college students, it was 25.86 mm.</p><p><strong>Conclusions: </strong>Overall, with the birth decade, average axial length increased and corneal curvature decreased. There were generational differences in ocular biological parameters, changes in the eye might affect the incidence of eye diseases such as glaucoma and fundus diseases, which in turn might lead to changes in the spectrum of eye diseases.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1373-1379"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive assessment of intracranial compliance in idiopathic intracranial hypertension: an MRI-ICP study.","authors":"Matilde Sassani, James L Mitchell, Andreas Yiangou, Nigel Davies, Vijay Sawlani, Susan P Mollan, Mark E Wagshul, Alexandra J Sinclair","doi":"10.1038/s41433-024-03547-7","DOIUrl":"10.1038/s41433-024-03547-7","url":null,"abstract":"<p><strong>Background/objectives: </strong>Idiopathic intracranial hypertension (IIH) is a disease which threatens vision and causes disabling headaches, affecting women of childbearing age with obesity. It is characterised by raised intracranial pressure (ICP), measured invasively either with lumbar punctures or intracranially-inserted monitors. There is an unmet clinical need to develop non-invasive means to assess ICP. This study aims to utilise the MRI-ICP imaging technique to measure intracranial compliance index and assess its suitability as surrogate biomarker of ICP.</p><p><strong>Subjects/methods: </strong>Nine IIH patients and ten age, sex, and body mass index matched healthy controls were recruited. All participants underwent lumbar puncture, visual assessments, detailed headache phenotyping, and MRI-ICP scans to calculate intracranial compliance index at baseline. Following treatment, patients were invited to attend a one-year visit when all assessments were repeated.</p><p><strong>Results: </strong>There was significant (p = 0.017) reduction in intracranial compliance index in IIH (mean = 1006.0 cc/mmHg/cm, SD = ± 384.6 cc/mmHg/cm) compared to controls (mean = 1493.0 cc/mmHg/cm, SD = ± 411.8 cc/mmHg/cm), inversely correlating with lumbar puncture opening pressure (r = -0.502, p = 0.029). A significant inverse correlation between compliance index and headache disability was also found (r = -0.458, p = 0.049) and a trend for an association between lower compliance index and increased frequency of headaches (r = -0.430, p = 0.066). This latter became significant (p = 0.018) after accounting for use of analgesics. Following successful treatment, compliance index was increased in all patients at one year (mean of differences = 380.7 cc/mmHg/cm, p = 0.031).</p><p><strong>Conclusions: </strong>This is the first study to apply the MRI-ICP technique longitudinally in IIH. It illustrates reduced intracranial compliance index in IIH, correlating with opening pressure and headache disability and ameliorating with treatment.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1309-1317"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normative data for dimensions of the frontal and infraorbital nerves.","authors":"Jessica Y Tong, Jeffrey Sung, Khizar Rana, WengOnn Chan, Alkis J Psaltis, Dinesh Selva","doi":"10.1038/s41433-025-03679-4","DOIUrl":"10.1038/s41433-025-03679-4","url":null,"abstract":"<p><strong>Objectives: </strong>To present a series of normative measurements for the width of the frontal and infraorbital nerve branches of V1 and V2, respectively.</p><p><strong>Methods: </strong>Cadaveric dissection study of 15 embalmed cadaver heads (30 orbits). The frontal nerve was excised en bloc from the superior orbital rim to the superior orbital fissure. Similarly, the infraorbital nerve was excised en bloc from the inferior orbital rim to the orbital apex. Measurements were recorded of the maximal width of the frontal nerve, infraorbital nerve within the orbital floor, and pterygopalatine segment of the maxillary nerve. Any value greater than 2 standard deviations (SD) above the mean value, was defined as nerve enlargement.</p><p><strong>Results: </strong>The mean transverse diameter of the frontal nerve was 2.27 ± 0.66 mm (1 SD). The mean transverse diameter of the infraorbital nerve branch, and the maxillary nerve within the pterygopalatine fossa, was 3.31 ± 0.68 mm (1 SD) and 3.59 ± 0.76 mm (1 SD), respectively. The upper limit of normal, defined as 2 SD above the mean value, for the widths of the frontal nerve, infraorbital nerve, and pterygopalatine segment of V2 widths were 3.59 mm, 4.67 mm, and 5.10 mm, respectively.</p><p><strong>Conclusions: </strong>The frontal and infraorbital nerves are implicated in various inflammatory and neoplastic orbital pathologies. Defining the normative data for width is important to compare with pathological states.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1390-1393"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Scottish Retinal Detachment Study: 10-year outcomes after retinal detachment repair.","authors":"James E Hazelwood, Danny Mitry, Jaswinder Singh, Harry G B Bennett, Ashraf A Khan, Colin R Goudie","doi":"10.1038/s41433-025-03613-8","DOIUrl":"10.1038/s41433-025-03613-8","url":null,"abstract":"<p><strong>Objective: </strong>To address the paucity of long-term data on outcomes following rhegmatogenous retinal detachment (RRD) repair we aimed to establish the 10-year best corrected visual acuity (BCVA), redetachment rate and lens status for patients from the Scottish Retinal Detachment Study.</p><p><strong>Subjects: </strong>Data from patients who presented with RRD during the original study were collected from clinical records 10 years after repair. Patients were excluded if lacking 10 year follow-up data, and excluded from visual acuity analysis in the case of significant co-morbid ophthalmic disease.</p><p><strong>Results: </strong>103 patients had BCVA outcomes for at least 10 years post-operatively and met the inclusion criteria. 57 were macula-on and 46 were macula-off. Median10-year BCVA was 0.1 (IQR 0.3) logMAR (6/7.5). 10-year BCVA was significantly better in macula-on patients, compared to macula-off (-0.18 logMAR (p < 0.001)). There was a significant improvement in macula-off BCVA from short-term follow-up to 10-year BCVA (-0.26 logMAR, p = 0.04). 93% of macula-on patients achieved BCVA sufficient for UK driving standard compared to 65% of macula-off. There was no difference in 10-year BCVA between repair techniques. Thirty-four patients were phakic at follow-up, 65 pseudophakic, and 4 aphakic. Redetachment occurred in 14% and conferred a poorer 10-year BCVA (logMAR 0.3 IQR 0.78 (6/12)).</p><p><strong>Conclusion: </strong>Long-term BCVA remains excellent following successful macula-on RRD repair with almost all macula-on, and most macula-off patients achieving the UK visual acuity driving standard. We demonstrate that macula-on detachments have significantly greater long long-term visual acuity than macula-off detachments, and that re-detachment is uncommon but confers a poorer long term visual outcome. This study provides objective long-term data to guide patient and surgeon expectations following retinal detachment repair.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1318-1321"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From pro-re-nata to fixed-interval regimen: evolving real-world treatment paradigms in anti-VEGF therapy for neovascular AMD.","authors":"Daniele Veritti, Valentina Sarao, Paolo Lanzetta","doi":"10.1038/s41433-025-03627-2","DOIUrl":"10.1038/s41433-025-03627-2","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the impact of evolving treatment paradigms for neovascular age-related macular degeneration (nAMD) by comparing outcomes between two patient cohorts treated with different anti-vascular endothelial growth factor (anti-VEGF) regimens over a decade apart.</p><p><strong>Methods: </strong>This retrospective cohort study included 200 treatment-naive nAMD patients divided into two cohorts. Cohort 1 (2009-2010) was treated with a pro re nata (PRN) regimen, involving three initial monthly injections followed by as-needed treatments based on monthly monitoring. Cohort 2 (2019-2021) received a fixed-interval regimen, consisting of three initial monthly injections followed by bimonthly maintenance doses. Primary outcomes included changes in best corrected visual acuity (BCVA) and central retinal thickness (CRT) at 12 months. Secondary outcomes included the number of injections, follow-up visits, and adherence to treatment schedules.</p><p><strong>Results: </strong>Cohort 2 demonstrated significantly greater improvement in BCVA (+5.5 vs -2.0 ETDRS letters, p < 0.001) and CRT reduction (-101.7 vs -26.5 μm, p < 0.001) compared to Cohort 1. Patients in Cohort 2 received more injections (7.7 vs 4.8, p < 0.001) but required fewer monitoring visits (3.2 vs 5.1, p < 0.001). Adherence to treatment schedules was markedly higher in Cohort 2 (78% vs 0%, p < 0.001).</p><p><strong>Conclusions: </strong>The transition from a PRN to a fixed-interval anti-VEGF regimen significantly improved visual and anatomical outcomes in nAMD patients. Fixed-interval regimens not only enhanced treatment efficacy but also optimized resource utilization, suggesting a superior approach for managing nAMD in a real-world clinical setting.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1349-1355"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}