Eye最新文献

{"title":"Topography-guided, patterned, customized corneal crosslinking for non-invasive astigmatism correction.","authors":"Zixin Fan, Xinyi Jiang, Suwen Zhao, Ningxin Dou, Fei Yao, Shaochong Zhang, Gangpei Cai, Yang Li, Yiheng Wu, Weidong He, Guoming Zhang, Shengli Mi","doi":"10.1038/s41433-025-03602-x","DOIUrl":"https://doi.org/10.1038/s41433-025-03602-x","url":null,"abstract":"<p><strong>Objectives: </strong>To propose and evaluate a novel, non-invasive approach for enduring corneal astigmatism correction based on topography-guided, patterned, customized riboflavin-ultraviolet A corneal collagen crosslinking (CXL).</p><p><strong>Methods: </strong>Astigmatism was modelled on both eyes of rabbits. A randomly selected eye of each rabbit was treated by the proposed CXL procedure with another eye as control. The proposed procedure was performed by a self-built intelligent platform through delivering ultraviolet A lattice in a refined and patterned manner, based on pre-operative corneal topography. The long-term effectiveness, stability, and safety were investigated for 180 days, with topographic measurements, anterior segment optical coherence tomography (AS-OCT), and in vivo corneal confocal microscopy (IVCM).</p><p><strong>Results: </strong>Spatially selective demarcation lines in AS-OCT images and trabecular patterned hyperdense structure with abundant needle-like processes in IVCM images were detected in the CXL eyes, revealing spatially selective crosslinking. Reductions of astigmatic magnitude (in the steep axis: 0.46 ± 0.28 vs. 2.15 ± 0.58 dioptres, P < 0.001) and high order aberration (0.38 ± 0.18 vs. 0.59 ± 0.19, P = 0.009) with increase of visual strehl ratio (0.21 ± 0.06 vs. 0.13 ± 0.03, P < 0.001) were found in the CXL eyes after CXL and maintained for 180 days, compared to inconspicuous changes in the control eyes. No obvious opacity and inflammation were observed in the CXL eyes, and transient loss of endothelial cells in the treated area was recovered in the subsequent visit.</p><p><strong>Conclusions: </strong>The proposed novel, non-invasive approach safely fulfilled corneal astigmatism correction with visual quality improvement as well as a decrease in high-order aberration.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A multifactorial, evidence-based analysis of pathophysiology in Spaceflight Associated Neuro-Ocular Syndrome (SANS).","authors":"Laura A Galdamez, Thomas H Mader, Joshua Ong, Cihan Mehmet Kadipasaoglu, Andrew G Lee","doi":"10.1038/s41433-025-03618-3","DOIUrl":"https://doi.org/10.1038/s41433-025-03618-3","url":null,"abstract":"<p><p>The National Aeronautics and Space Administration (NASA) in the United States has been studying a fascinating and unique constellation of neuro-ophthalmic findings collectively known as Spaceflight Associated Neuro-Ocular Syndrome (SANS). SANS is unique to the space environment of microgravity and produces novel physiological and pathological findings that have no direct terrestrial equivalent. The neuro-ophthalmic phenomenon is a major physiologic barrier to future planetary spaceflight. The underlying pathophysiology of SANS remains ill-defined, but since its initial report in 2011, several hypotheses have been proposed including increased intracranial pressure, cerebral venous congestion and glymphatic stasis, compartmentalization of CSF within the orbital nerve sheath sub-arachnoid space (SAS), upward brain shift, inflammation, disrupted axoplasmic transport, and radiation exposure. These aetiologies may not be mutually exclusive and may be interconnected, leading to an integrative, multifactorial aetiology of SANS. This paper critically analyses the various hypotheses of this neuro-ophthalmic phenomenon and the connections between the physiologic and anatomical evidence-based changes observed in spaceflight and terrestrial analogues. Continued prospective, longitudinal study and development of practical countermeasures for SANS will be necessary for future human spaceflight missions including the mission to Mars.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fundus vascular arcades angle reflects choroidal thickness in highly myopic children and adolescents.","authors":"Wei Gong, Bo Zhang, Dengji Zhou, Saiguang Ling, Jinliuxing Yang, Jun Chen, Jingjing Wang, Xun Xu, Xiangui He, Wei Gao","doi":"10.1038/s41433-025-03604-9","DOIUrl":"https://doi.org/10.1038/s41433-025-03604-9","url":null,"abstract":"<p><strong>Objectives: </strong>To identify the role of fundus vascular arcades angle (VAA) in reflecting choroidal thickness (ChT) of highly myopic children and adolescents.</p><p><strong>Methods: </strong>Participants aged 5 to 18 yrs with high myopia (spherical equivalent, SE ≤ -5.0 D) were enrolled and followed up for one year from the Shanghai Child and Adolescent Large-scale Eye Study. The VAA in the range of one papillary diameter (PD) as well as 2PD away from the central point of optic disc was recognized and measured by artificial intelligence from fundus photographs.</p><p><strong>Results: </strong>Finally, 277 highly myopic participants were included in the analysis. The mean VAA (1PD) was 128.38 ± 9.56°, and the mean VAA (2PD) was 110.25 ± 11.97°. For those with larger VAA, the choroidal thickness around macula (mChT) or papillary (pChT) was thicker (P for trend < 0.05). After adjusting for age and gender, thinner ChT was independently associated with smaller VAA (P < 0.001). For those with more decrease of VAA, the thinning of ChT was more remarkable (P < 0.05). In the regression analysis, more change of pChT was independently associated with more change of VAA (P < 0.01). After adjusting for other related parameters, 1°change of VAA (1PD) or VAA (2PD) accounted for 0.855 mm or 0.719 mm change of pChT.</p><p><strong>Conclusions: </strong>Fundus VAA was closely associated with choroidal thickness in highly myopic paediatric population. It could serve as an alternative indicator of choroid thickness in the fundus screening for evaluating the risk of pathological changes of high myopia.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extrapulmonry Tuberculosis in a Child Presenting as an Eyelid Cyst.","authors":"Prabrisha Banerjee, Kirthi Koka, Bipasha Mukherjee","doi":"10.1038/s41433-025-03611-w","DOIUrl":"https://doi.org/10.1038/s41433-025-03611-w","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute idiopathic frosted branch angiitis.","authors":"Bangtao Yao, Yinling Wu, Yuhua Ding","doi":"10.1038/s41433-025-03606-7","DOIUrl":"https://doi.org/10.1038/s41433-025-03606-7","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hardy-Rand-Rittler colour vision testing in cone and cone-rod dystrophies: correlation with structural and functional outcome measures","authors":"Brindhan Tharmarajah,&nbsp;Elisa E. Cornish,&nbsp;Jonathan Nguyen,&nbsp;Elizabeth Barnes,&nbsp;Kate E. Leahy,&nbsp;Anagha Vaze,&nbsp;Robyn V. Jamieson,&nbsp;John R. Grigg","doi":"10.1038/s41433-024-03584-2","DOIUrl":"10.1038/s41433-024-03584-2","url":null,"abstract":"To determine how Hardy-Rand-Rittler (HRR) colour vision testing correlates with visual functional and structural assessments in Cone and Cone-Rod Dystrophy. Thirty-four Cone and 69 Cone-Rod Dystrophy patients diagnosed by electroretinography (ERG) at the Save Sight Institute in Sydney were included in a retrospective analysis. Each patient’s HRR colour vision test scores were compared with markers of cone and rod system function including visual acuity (VA), ERG responses, changes on Spectral Domain Optical Coherence Tomography (OCT) and Fundus Autofluorescence. The number of plates identified on HRR testing correlated with logMAR best-corrected distance VA; r(101) = −0.49, p &lt; 0.0001. HRR scores correlated with markers of cone and macula function including OCT Ellipsoid Zone Gap Width, Central Macular and Outer Nuclear Layer Thickness, Full Field ERG 30 Hz flicker amplitudes, light adapted 3.0 b-wave amplitudes and Pattern ERG 15- and 30-degree p50 amplitudes. HRR colour vision testing correlates with structural and functional measures in Cone and Cone-Rod Dystrophy. HRR colour vision testing provides a simple clinic-based option to monitor disease changes in Cone and Cone-Rod Dystrophy patients, especially when ERG testing is not available.","PeriodicalId":12125,"journal":{"name":"Eye","volume":"39 3","pages":"527-532"},"PeriodicalIF":2.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41433-024-03584-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: ‘Myopic traction maculopathy in fovea-involved myopic chorioretinal atrophy’","authors":"Maurizio Mete,&nbsp;Luigi Fontana,&nbsp;Antonio Moramarco","doi":"10.1038/s41433-025-03612-9","DOIUrl":"10.1038/s41433-025-03612-9","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":"39 3","pages":"608-608"},"PeriodicalIF":2.8,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Macular, choroidal and disc associations across women’s reproductive life stages: a scoping review from menarche to post-menopause","authors":"Ana Paula Ribeiro Reis,&nbsp;Estelle Ioannidou,&nbsp;Kelsey V. Stuart,&nbsp;Siegfried K. Wagner,&nbsp;Paul J. Foster,&nbsp;Anthony P. Khawaja,&nbsp;Axel Petzold,&nbsp;Sobha Sivaprasad,&nbsp;Nikolas Pontikos,&nbsp;Pearse A. Keane,&nbsp;Konstantinos Balaskas,&nbsp;Praveen J. Patel","doi":"10.1038/s41433-025-03592-w","DOIUrl":"10.1038/s41433-025-03592-w","url":null,"abstract":"Oestrogen and progesterone fluctuate cyclically in women throughout their adult lives. Although these hormones cross the blood-retinal barrier and bind to intraocular receptors, their effects remain unclear. We present the first review to date on associations between posterior pole structures—specifically the macula, choroid, and optic disc—and both&nbsp;the menstrual cycle and post-menopausal period, utilising multimodal imaging techniques in healthy adult non-pregnant women. We excluded studies on contraception and hormonal replacement therapy, focusing solely on physiological associations. Despite the comprehensive scope of our review, limited data and inconsistent reporting among studies prevented the establishment of meaningful trends. Across menstrual cycle phases, choroidal thickness (CHT) was the most consistently reported parameter, with thinning during the luteal phase compared to the follicular phase. Conversely, no significant differences were observed in macular or disc morphology across the cycle, likely reflecting a preserved structure despite potential fluctuations in blood flow and perfusion. Studies comparing pre- and post-menopausal associations, after adjusting for age or body mass index (BMI), failed to reveal meaningful trends, highlighting the difficulty in separating the effect of age from hormonal declines in older women. Understanding how hormonal cycles impact the posterior pole in women is crucial for addressing sex differences in various ocular pathologies. Research on female-specific factors is still sparse, and interestingly, the majority of affiliations in the reviewed articles did not originate from regions with the highest biomedical research funding and publication rates. We encourage further studies focusing on female-specific variables and provide recommendations for future designs.","PeriodicalId":12125,"journal":{"name":"Eye","volume":"39 3","pages":"402-411"},"PeriodicalIF":2.8,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41433-025-03592-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy-induced bilateral peripheral ulcerative keratitis.","authors":"Aafreen Bari, Himanshu Khandelwal, Chetan Shakkarwal, Tushar Agarwal, Tanuj Dada, Namrata Sharma","doi":"10.1038/s41433-025-03601-y","DOIUrl":"https://doi.org/10.1038/s41433-025-03601-y","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound guided Ru106 plaque brachytherapy for treatment of exudative retinal detachment in children with diffuse choroidal haemangioma","authors":"Anusha Venkataraman,&nbsp;Ali Al-Gilgawi,&nbsp;Ian Stoker,&nbsp;M. Ashwin Reddy,&nbsp;Mandeep S. Sagoo","doi":"10.1038/s41433-024-03562-8","DOIUrl":"10.1038/s41433-024-03562-8","url":null,"abstract":"To evaluate the efficacy of ultrasound-guided ruthenium (Ru 106) plaque brachytherapy for treatment of exudative retinal detachment in diffuse choroidal haemangioma (DCH). Retrospective analysis of four paediatric patients treated with ultrasound-guided Ru 106 plaque brachytherapy for DCH with total exudative retinal detachment directed to the thickest part of the DCH. A dose of 40 Gy to the tumour apex was delivered in all patients. The outcomes of treatment were regression of DCH, resolution of retinal detachment, development of neovascular glaucoma or any other radiation-associated complications which were assessed clinically and with B scan ultrasonography. There were 4 eyes included in the study, with a mean (median, range) age of 8.75 (8.4, 3–15) years. The pre-operative tumour thickness was 5.0 (5.12, 4.2–5.5) mm. The visual acuity ranged from 0.8-2.8 LogMAR and 3 of 4 eyes had only light perception at presentation. One eye had been treated with goniotomy for pre-existing secondary glaucoma and was on topical antihypertensive medications. At a mean follow-up of 14.6 months (10.5 months, 6-30 months), all patients showed regression of the tumour. The mean tumour thickness reduced to 2.05 mm (2.44 mm, 1.1–2.6 mm) post-operatively. All patients (4/4) had complete resolution of the retinal detachment. The visual acuity remained stable in all the patients with none of the patients developing neovascular glaucoma or any other radiation-related complications. Ultrasound-guided Ru 106 plaque brachytherapy is an effective treatment strategy as a primary treatment in the absence of external beam radiotherapy, to achieve tumour regression and resolution of retinal detachment in DCH.","PeriodicalId":12125,"journal":{"name":"Eye","volume":"39 3","pages":"533-537"},"PeriodicalIF":2.8,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41433-024-03562-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}