IF 2.8 3区医学

Eye Pub Date : 2025-01-14 DOI: 10.1038/s41433-024-03586-0

Zhaoquan Wu, Wei Sun, Yulu Zhou, Chunjiang Wang

{"title":"Clinical features, treatment, and prognosis of zoledronic acid-induced uveitis","authors":"Zhaoquan Wu, Wei Sun, Yulu Zhou, Chunjiang Wang","doi":"10.1038/s41433-024-03586-0","DOIUrl":"10.1038/s41433-024-03586-0","url":null,"abstract":"Uveitis is a rare ocular adverse reaction of zoledronic acid, the specific clinical features are not clarified. This study was to investigate the clinical features of zoledronic acid-induced uveitis and provide reference for rational use of zoledronic acid. We collected clinical data on zoledronic acid-induced uveitis for retrospective analysis by searching Chinese and English data up to October 31, 2024. Uveitis occurred in 44 patients with a median age of 66.5 years (range 47, 87) and 93.2% in females. The median time to onset of uveitis was 48 h (range 10, 192). Eye pain (86.4%), decreased vision (61.4%), and redness (50.0%) were the most commonly described symptoms. Uveitis could involve unilateral eyes (68.2%) and bilateral eyes (31.8%), and anterior uveitis was the main type (95.5%). Most patients had intraocular pressure within the normal range. Slit lamp examination mainly revealed cells (54.5%), flare (43.2%), and keratic precipitates (29.5%). After discontinuation of zoledronic acid (97.6%) and receipt of topical steroids (97.7%), systemic steroids (15.9%), and cycloplegics (72.7%), all patients showed improvement or recovery. Zoledronic acid-induced uveitis mainly occurs within 72 h after the initial administration, and anterior uveitis is predominant. When zoledronic acid is used, patients should be informed of possible adverse eye reactions. Topical corticosteroids can be used as the main treatment for uveitis.","PeriodicalId":12125,"journal":{"name":"Eye","volume":"39 3","pages":"538-543"},"PeriodicalIF":2.8,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142983147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Solitary eyelid neurofibroma mimicking recurrent chalazion. 单眼神经纤维瘤模拟复发性色斑。

IF 2.8 3区医学

Eye Pub Date : 2025-01-14 DOI: 10.1038/s41433-025-03594-8

Vivek Singh, Md Shahid Alam

引用次数: 0

Anatomical and functional results of patients with late-stage age-related macular degeneration 6 months after smaller-incision new-generation implantable miniature telescope (SING IMT™) implantation 小切口新一代植入式微型望远镜（SING IMT™）植入术6个月后晚期老年性黄斑变性患者的解剖和功能结果

IF 2.8 3区医学

Eye Pub Date : 2025-01-13 DOI: 10.1038/s41433-025-03598-4

Ginevra Giovanna Adamo, Marco Pellegrini, Francesco Nasini, Pietro Maria Talli, Laura Sarti, Piera Perri, Francesco Parmeggiani, Marco Mura

{"title":"Anatomical and functional results of patients with late-stage age-related macular degeneration 6 months after smaller-incision new-generation implantable miniature telescope (SING IMT™) implantation","authors":"Ginevra Giovanna Adamo, Marco Pellegrini, Francesco Nasini, Pietro Maria Talli, Laura Sarti, Piera Perri, Francesco Parmeggiani, Marco Mura","doi":"10.1038/s41433-025-03598-4","DOIUrl":"10.1038/s41433-025-03598-4","url":null,"abstract":"The aim of the study was to evaluate anatomical and functional outcomes of the Smaller-Incision New Generation Implantable Miniature Telescope (SING IMT™) in patients with bilateral advanced age-related macular degeneration (AMD). This non-comparative retrospective single-surgeon interventional case series included patients with bilateral late-stage AMD who underwent cataract surgery and SING IMT™ implantation at the Sant’Anna University Hospital, University of Ferrara, Italy. The main outcome measures included corrected distance (CDVA) and near visual acuity (CNVA), endothelial cell loss (ECL), and incidence of complications. 11 eyes of 11 patients were included. The mean follow-up duration was 6.5 ± 2.4 months. After surgery, CDVA significantly improved (from 17.00 ± 9.74 to 26.00 ± 8.53) letters (P = 0.008). Significant improvement of CNVA was also observed (from 12.27 ± 4.36 to 8 ± 2.61 Jaeger levels; P = 0.004). Mean ECL was 4.8 ± 5.5% at 3 months. No intraoperative complications were observed, while postoperative complications included iris incarceration (9.1%), pigment deposition on the device (9.1%), and transient corneal oedema (27.3%). Nevertheless, 10 of 11 patients (90.9%) began to complain of blurred or hazy vision within 3 months of surgery. The device was ultimately explanted in 3 patients (27.3%) because of this symptom. Although SING IMT™ implantation is associated with promising objective results, unexplained blurred or hazy vision represents common postoperative complaints which may lead to patient dissatisfaction. Further studies including patient-reported outcomes are warranted to evaluate the effect of the intervention on patients’ visual function and quality of life.","PeriodicalId":12125,"journal":{"name":"Eye","volume":"39 3","pages":"544-547"},"PeriodicalIF":2.8,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infographic: Efficacy and safety of high-dose Intravitreal aflibercept 8 mg in patients with neovascular age-related macular degeneration: week 48 results from the phase 3 PULSAR trial. 信息图：8 mg高剂量玻璃体腔内注射阿布西普治疗新生血管性年龄相关性黄斑变性患者的疗效和安全性：PULSAR试验3期48周的结果。

IF 2.8 3区医学

Eye Pub Date : 2025-01-13 DOI: 10.1038/s41433-024-03543-x

Jeffrey S Heier, Xin Zhang, Kimberly Reed, Alyson Berliner, Sergio Leal

引用次数: 0

Forest of darkness: imaging with OCT-angiography as a useful tool to study corneal vascularization. 黑暗森林：oct血管成像是研究角膜血管化的有用工具。

IF 2.8 3区医学

Eye Pub Date : 2025-01-13 DOI: 10.1038/s41433-025-03593-9

Ritu Arora, Rushad Shroff, Palak Gupta, Jatin Arora

引用次数: 0

Efficacy and safety of robotic Cyberknife radiotherapy in uveal melanoma: a systematic review and meta-analysis 射波刀放射治疗葡萄膜黑色素瘤的疗效和安全性：系统综述和荟萃分析。

IF 2.8 3区医学

Eye Pub Date : 2025-01-11 DOI: 10.1038/s41433-024-03582-4

Kejie Du, Wenjuan Luo

{"title":"Efficacy and safety of robotic Cyberknife radiotherapy in uveal melanoma: a systematic review and meta-analysis","authors":"Kejie Du, Wenjuan Luo","doi":"10.1038/s41433-024-03582-4","DOIUrl":"10.1038/s41433-024-03582-4","url":null,"abstract":"This systematic review is aimed to evaluate the efficacy and safety of robotic Cyberknife radiotherapy (CKRT) in the treatment of uveal melanoma (UM). Clinical studies published in English that assessed the efficacy and safety of robotic CKRT in UM were systematically searched in PubMed, Web of Science, Cochrane and Embase from inception to July 2023. Studies reporting extraocular tumours or other radiosurgery approaches were excluded. Outcomes measured were tumour size, reflectivity, local tumour control rate, eye retention rate, survival rate, complication rate, recurrence rate, and metastasis rate. Ten eligible articles involving 2370 patients with 2372 UMs were included in evidence synthesis. Meta-analysis showed 811 of 912 patients (0.89, 95% Cl: 0.86, 0.92) maintained local control for three years, and 1448 of 1724 patients (0.84, 95% Cl: 0.81, 0.88) preserved the eye in three years. During follow-up, 91% (0.91, 95% Cl: 0.85, 0.97) patients survived and 351 of 1720 patients (0.23, 95% Cl: 0.09, 0.37) involving 1722 eyes had tumour recurrence. In addition, 1376 patients (0.79, 95% Cl: 0.77, 0.82) preserved the eyeball in five years. Following treatment, approximately 20% of patients had radiation retinopathy (95% Cl: 0.13, 0.28), 19% developed glaucoma (95% Cl: 0.11, 0.28), and 22% experienced retinal detachment (95% Cl: 0.07, 0.36). CKRT is a viable, noninvasive RT for UM. The rate of local tumour control following treatment is comparable to that of other RT approaches, providing additional options based on the patient’s condition.","PeriodicalId":12125,"journal":{"name":"Eye","volume":"39 3","pages":"548-555"},"PeriodicalIF":2.8,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Choriocapillaris flow in two different patterns of exudative type 1 macular neovascularization 绒毛膜毛细血管以两种不同的渗出型1型黄斑新生血管流动。

IF 2.8 3区医学

Eye Pub Date : 2025-01-10 DOI: 10.1038/s41433-024-03587-z

Pasquale Viggiano, Sibel Demirel, Giovanni Petruzzella, Mariagrazia Pignataro, Giacomo Boscia, Arcangelo Clemente, Enrico Borrelli, Michele Reibaldi, Giovanni Alessio, Jay Chhablani, Francesco Boscia

{"title":"Choriocapillaris flow in two different patterns of exudative type 1 macular neovascularization","authors":"Pasquale Viggiano, Sibel Demirel, Giovanni Petruzzella, Mariagrazia Pignataro, Giacomo Boscia, Arcangelo Clemente, Enrico Borrelli, Michele Reibaldi, Giovanni Alessio, Jay Chhablani, Francesco Boscia","doi":"10.1038/s41433-024-03587-z","DOIUrl":"10.1038/s41433-024-03587-z","url":null,"abstract":"To compare the characteristics of type 1 macular neovascularization (MNV) and the surrounding choriocapillaris (CC) perfusion in patients with neovascular age-related macular degeneration (nAMD) versus those with pachychoroid neovasculopathy (PNV) using swept-source optical coherence tomography angiography (SS-OCTA). This retrospective study included 64 treatment-naïve eyes (37 nAMD, 27 PNV) with type 1 MNV. SS-OCTA images were analysed to measure MNV area and perimeter, and CC flow deficits (FD) in five concentric rings surrounding the lesion. CC FD percentage (FD%), area (FDa), and number (FDn) were quantified. Intervortex anastomoses presence was also assessed. MNV lesions in nAMD were significantly larger in area (2.94 vs 1.56 mm², p = 0.013) and perimeter (8.76 vs 5.85 mm, p = 0.004) compared to PNV. PNV eyes showed higher FD% and larger FDa across all rings (p < 0.05), while FDn did not differ significantly. Intervortex anastomoses were more prevalent in PNV (81.5% vs 35.1%, p = 0.0002). In nAMD, MNV size correlated positively with FD% in inner rings and FDn in all rings. In PNV, MNV size correlated only with FDn. Despite smaller MNV lesions, PNV eyes demonstrated more extensive CC flow deficits compared to nAMD. The distinct CC flow patterns and their correlations with MNV characteristics suggest different pathophysiological mechanisms underlying these conditions. These findings may have implications for differential diagnosis and tailored treatment approaches in nAMD and PNV.","PeriodicalId":12125,"journal":{"name":"Eye","volume":"39 3","pages":"556-562"},"PeriodicalIF":2.8,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishing normal interocular symmetry range for macular optical coherence tomography parameters in healthy children 建立健康儿童黄斑光学相干断层扫描参数的正常眼间对称范围。

IF 2.8 3区医学

Eye Pub Date : 2025-01-10 DOI: 10.1038/s41433-024-03591-3

Athar Zareei, Reza Razeghinejad, Mohammad Reza Talebnejad, Mohammad Reza Khalili, Masoumeh Sadat Masoumpour, Zahra Shayan, Hamideh Mahdaviazad, Maryam Keshtkar, Elham Mohammadi, Zahra Tajbakhsh, M. Hossein Nowroozzadeh

{"title":"Establishing normal interocular symmetry range for macular optical coherence tomography parameters in healthy children","authors":"Athar Zareei, Reza Razeghinejad, Mohammad Reza Talebnejad, Mohammad Reza Khalili, Masoumeh Sadat Masoumpour, Zahra Shayan, Hamideh Mahdaviazad, Maryam Keshtkar, Elham Mohammadi, Zahra Tajbakhsh, M. Hossein Nowroozzadeh","doi":"10.1038/s41433-024-03591-3","DOIUrl":"10.1038/s41433-024-03591-3","url":null,"abstract":"The study aimed to evaluate the interocular symmetry of macular sublayer thickness among healthy children aged 6-12 years. The Shiraz Pediatric Eye Study included 500 randomly selected children who underwent SD-OCT of the macula and optical biometry using the IOLMaster-500. Exclusion criteria involved ocular abnormalities or axial lengths outside the 21.5–26.5 mm range. Software recorded total retinal thickness and sublayer thickness within each ETDRS subfield. The study included 862 eyes from 431 healthy children, with 254 girls (59%). The anticipated variation in total retinal thickness between eyes was below 13 µm in the fovea and under 7 µm in the inner or outer ring for 95% of the population. For nerve fiber layer and inner plexiform layer, the expected variation ranged from 2 to 4 µm, and for the ganglion-cell layer, it ranged from 2.5 to 5 µm. Intraclass correlation coefficient (ICC) rankings for retinal topography were highest in the outer ring, followed by the inner ring and fovea. The highest ICC for individual layers was found in overall retinal thickness, followed by inner retinal layers, outer-nuclear layer, inner plexiform layer, and inner nuclear layer. The study establishes a reliable reference range for interocular variances in macular sublayers, aiding clinical decision-making. The outer ring (3–6 mm) is most dependable for analysing most sublayers, while the inner ring is most suitable for examining the ganglion-cell layer.","PeriodicalId":12125,"journal":{"name":"Eye","volume":"39 3","pages":"563-569"},"PeriodicalIF":2.8,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep learning model for automatic detection of different types of microaneurysms in diabetic retinopathy 糖尿病视网膜病变不同类型微动脉瘤自动检测的深度学习模型。

IF 2.8 3区医学

Eye Pub Date : 2025-01-09 DOI: 10.1038/s41433-024-03585-1

Giovanni Neri, Sohum Sharma, Beatrice Ghezzo, Cristina Novarese, Chiara Olivieri, Davide Tibaldi, Paola Marolo, Daniel B. Russakoff, Jonathan D. Oakley, Michele Reibaldi, Enrico Borrelli

{"title":"Deep learning model for automatic detection of different types of microaneurysms in diabetic retinopathy","authors":"Giovanni Neri, Sohum Sharma, Beatrice Ghezzo, Cristina Novarese, Chiara Olivieri, Davide Tibaldi, Paola Marolo, Daniel B. Russakoff, Jonathan D. Oakley, Michele Reibaldi, Enrico Borrelli","doi":"10.1038/s41433-024-03585-1","DOIUrl":"10.1038/s41433-024-03585-1","url":null,"abstract":"This study aims to develop a deep-learning-based software capable of detecting and differentiating microaneurysms (MAs) as hyporeflective or hyperreflective on structural optical coherence tomography (OCT) images in patients with non-proliferative diabetic retinopathy (NPDR). A retrospective cohort of 249 patients (498 eyes) diagnosed with NPDR was analysed. Structural OCT scans were obtained using the Heidelberg Spectralis HRA + OCT device. Manual segmentation of MAs was performed by five masked readers, with an expert grader ensuring consistent labeling. Two deep learning models, YOLO (You Only Look Once) and DETR (DEtection TRansformer), were trained using the annotated OCT images. Detection and classification performance were evaluated using the area under the receiver operating characteristic (ROC) curves. The YOLO model performed poorly with an AUC of 0.35 for overall MA detection, with AUCs of 0.33 and 0.24 for hyperreflective and hyporeflective MAs, respectively. The DETR model had an AUC of 0.86 for overall MA detection, but AUCs of 0.71 and 0.84 for hyperreflective and hyporeflective MAs, respectively. Post-hoc review revealed that discrepancies between automated and manual grading were often due to the automated method’s selection of normal retinal vessels. The choice of deep learning model is critical to achieving accuracy in detecting and classifying MAs in structural OCT images. An automated approach may assist clinicians in the early detection and monitoring of diabetic retinopathy, potentially improving patient outcomes.","PeriodicalId":12125,"journal":{"name":"Eye","volume":"39 3","pages":"570-577"},"PeriodicalIF":2.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142947122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monkeypox infection and risk for uveitis 猴痘感染和葡萄膜炎的风险。

IF 2.8 3区医学

Eye Pub Date : 2025-01-09 DOI: 10.1038/s41433-024-03579-z

Alan Y. Hsu, Chun-Chi Chiang, Yi-Ching Shao, Ning-Yi Hsia, Chun-Ting Lai, Chun-Ju Lin, Huan-Sheng Chen, Yi-Yu Tsai, Yu-Hsun Wang, James Cheng-Chung Wei

引用次数: 0

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