IF 4.4 3区医学

Eye Pub Date : 2026-10-01 DOI: 10.1038/s41433-026-04845-y

Shreyas Gore, Muthukrishnan V, Naresh Babu K

引用次数: 0

Multidrug antifungal resistance and clinical outcomes in fungal keratitis: a prospective study in a South Indian population. 真菌性角膜炎的多药抗真菌耐药性和临床结果：南印度人群的前瞻性研究。

IF 4.4 3区医学

Eye Pub Date : 2026-10-01 DOI: 10.1038/s41433-026-04938-8

Leonie Fingerhut, Ramakrishnan Vigneshwar, Florence Burté, Manojkumar Vimala Devi, Rathinavel Sethu Nagarajan, Rajarathinam Karpagam, Venkatesh Prajna, Bethany Mills, Prajna Lalitha

{"title":"Multidrug antifungal resistance and clinical outcomes in fungal keratitis: a prospective study in a South Indian population.","authors":"Leonie Fingerhut, Ramakrishnan Vigneshwar, Florence Burté, Manojkumar Vimala Devi, Rathinavel Sethu Nagarajan, Rajarathinam Karpagam, Venkatesh Prajna, Bethany Mills, Prajna Lalitha","doi":"10.1038/s41433-026-04938-8","DOIUrl":"https://doi.org/10.1038/s41433-026-04938-8","url":null,"abstract":"Objectives: Our primary objective was to identify the rate of antifungal resistance (including multidrug resistance) of fungal isolates cultured from fungal keratitis patients in South India. Our secondary objective was to identify associations between antifungal resistance and patient outcome.Subjects/methods: 153 patients attending the cornea clinic at Aravind Eye Hospital, Madurai (May-August 2025) with culture-positive fungal keratitis were enrolled in the study. Cultured isolates were evaluated for natamycin, amphotericin B, voriconazole and econazole minimum inhibitory concentration (MIC; n = 151-153). MIC data were analysed by Kruskal-Wallis test followed by Dunn's multiple comparisons. Patient disease outcome relative to isolate resistance was analysed by Fisher's exact test (n = 91).Results: There were high levels of resistance to all four antifungals, which were significantly elevated in Fusarium spp. and Aspergillus spp. isolates compared to other fungal genera (P < 0.0001). Fusarium spp. isolates (n = 81) resistant to: natamycin: 38.3%; amphotericin B: 93.8%; voriconazole: 97.5%; and econazole: 76.5%. Aspergillus spp. isolates (n = 33) resistant to: natamycin: 66.7%; amphotericin B: 87.9%; voriconazole: 6.1%; and econazole: 0%. Overall, fungal resistance to natamycin significantly correlated with an adverse clinical outcome, P = 0.0034, relative risk 1.7 (95% CI: 1.2-2.6).Conclusions: The majority of fungal isolates were resistant to multiple antifungals; none of the Fusarium isolates were susceptible to all four drugs, and 28% were resistant to all of them. Resistance to natamycin may worsen clinical outcome, particularly for infections caused by Aspergillus, even when susceptible to azoles. Our data support the need for species-specific MIC thresholds to have increased clinical utility.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced keratometry for IOL power calculation after myopic LASIK: a multi-device comparison. 近视LASIK术后增强角膜测光术用于人工晶状体度数计算：多设备比较。

IF 4.4 3区医学

Eye Pub Date : 2026-10-01 DOI: 10.1038/s41433-026-04908-0

Hung-Yuan Lin, Chia-Chieh Hsiao, Ya-Jung Chuang, Pi-Jung Lin

{"title":"Enhanced keratometry for IOL power calculation after myopic LASIK: a multi-device comparison.","authors":"Hung-Yuan Lin, Chia-Chieh Hsiao, Ya-Jung Chuang, Pi-Jung Lin","doi":"10.1038/s41433-026-04908-0","DOIUrl":"https://doi.org/10.1038/s41433-026-04908-0","url":null,"abstract":"Background: To comparatively evaluate the predictive accuracy of Lenstar 900, IOL Master 700, OptiWave refractive analysis (ORA) and a modified Placido topography method in patients undergoing cataract surgery following myopic laser-assisted in situ keratomileusis (LASIK).Methods: A cohort of 62 post-myopic LASIK eyes from 37 patients was enrolled. Six methods were employed to estimate intraocular lens (IOL) power: Lenstar Barrett true K (BTK), Lenstar Shammas, IOL Master BTK, IOL Master BTK with total keratometry (TK), ORA and a modified Placido topography method.Results: Mean prediction errors and mean absolute errors were lowest to highest for the modified Placido topography method, IOL Master BTK with TK and IOL Master BTK, respectively. The IOL Master BTK, Lenstar BTK and ORA method did not significantly differ from each other. All methods outperformed Lenstar Shammas. At 2 months postoperatively, the modified Placido topography method had the highest percentages of eyes with manifest absolute prediction errors within 0.50 and 1.00 D (91.9%, 100%), followed by IOL Master BTK with TK (67.7%, 100%), IOL Master BTK (62.9%, 95.2%), ORA (54.8%, 95.2%), Lenstar BTK (53.2%, 95.2%) and Lenstar Shammas (38.7%, 67.7%).Conclusion: The BTK formula was highly accurate in predicting IOL power for patients undergoing cataract surgery after myopic LASIK. However, variations in keratometry values can influence outcomes. In this study, the modified Placido topography method was the most accurate, followed by IOL Master BTK with TK, IOL Master BTK, ORA, Lenstar BTK and Lenstar Shammas.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Choroidal tuberculoma as an initial presenting sign of miliary tuberculosis. 脉络膜结核瘤是军旅性结核的最初表现。

IF 4.4 3区医学

Eye Pub Date : 2026-10-01 DOI: 10.1038/s41433-026-04875-6

Nan Zhou, Lihong Yang, Wenbin Wei

引用次数: 0

Earliest descriptions of retinal cells. 视网膜细胞的最早描述。

IF 4.4 3区医学

Eye Pub Date : 2026-09-30 DOI: 10.1038/s41433-026-04935-x

Paulus T V M de Jong, Eduard G Huijsmans

引用次数: 0

Flash-count-evoked pupil contraction during temporal discrimination in adult strabismic amblyopia. 在成人斜视弱视的时间辨别中，闪数诱发瞳孔收缩。

IF 4.4 3区医学

Eye Pub Date : 2026-09-30 DOI: 10.1038/s41433-026-04900-8

Aaron Khodami, Luca Battaglini

引用次数: 0

The hammer's hidden guest: an intralenticular surprise. 锤子的隐藏客人：一个眼球内的惊喜。

IF 4.4 3区医学

Eye Pub Date : 2026-09-30 DOI: 10.1038/s41433-026-04955-7

Neethu Lakshmi N, Md Alban Uddin, Madhu Shekhar

引用次数: 0

Analysis of Canadian ophthalmologists' age of death between 2000 and 2023: a comparative retrospective cross-sectional study. 2000年至2023年加拿大眼科医生死亡年龄分析：一项比较回顾性横断面研究

IF 4.4 3区医学

Eye Pub Date : 2026-09-30 DOI: 10.1038/s41433-026-04957-5

Amir-Ali Golrokhian-Sani, Emaan Chaudry, Maya Morcos, Marc Morcos, Angela Li, Alfred Basilious

{"title":"Analysis of Canadian ophthalmologists' age of death between 2000 and 2023: a comparative retrospective cross-sectional study.","authors":"Amir-Ali Golrokhian-Sani, Emaan Chaudry, Maya Morcos, Marc Morcos, Angela Li, Alfred Basilious","doi":"10.1038/s41433-026-04957-5","DOIUrl":"https://doi.org/10.1038/s41433-026-04957-5","url":null,"abstract":"Objective: The objective of this study is to assess the lifespan of ophthalmologists in Canada relative to that of other Canadian physicians and surgeons.Methods: In December 2023, obituaries published in the Canadian Medical Association Journal (CMAJ) from 2000 to 2023 were manually collected. A Python program was created to collect age at death, physician speciality, and year of death from each obituary. The full methodology is described in our pilot study [1]. A univariate general linear model was employed to evaluate the relationship between medical speciality and average age of death. Model performance was assessed using the coefficient of determination (R2). Estimated marginal means were computed to provide estimates for the age of death for each cohort. The three speciality categories of surgeons (excluding ophthalmologists), ophthalmologists, and all other physicians (excluding surgeons and ophthalmologists) were compared in a pairwise manner. A Bonferroni correction was applied to the data for statistical rigour. Significance was defined as p < 0.05.Results: In total, 2645 physicians were included in the analysis: 312 surgeons (excluding ophthalmologists), 109 ophthalmologists, and 2224 physicians in other specialities (excluding physicians and ophthalmologists). Surgeons, on average, lived approximately 4 years longer than non-surgical physicians (p < 0.001) and 2 years longer than ophthalmologists (p = 0.620). Ophthalmologists lived approximately 3 years longer than non-surgical physicians, though this was not statistically significant (p = 0.122).","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to: Comment on 'A call to develop rigorous standards for excellence in idiopathic intracranial hypertension: RISE-IIH'. 对“呼吁制定严格的特发性颅内高压卓越标准：RISE-IIH”的评论。

IF 4.4 3区医学

Eye Pub Date : 2026-09-30 DOI: 10.1038/s41433-026-04945-9

Gabriele Berman, Daisy MacKeith, Michael Lowe, Joanne Adeoye, Susan P Mollan

引用次数: 0

Patient-reported outcome measures 1 year after conjunctival melanoma treatment using EORTC QLQ-C30 and QLQ-OPT30 questionnaires. 使用EORTC QLQ-C30和QLQ-OPT30问卷调查结膜黑色素瘤治疗后1年患者报告的结果测量。

IF 4.4 3区医学

Eye Pub Date : 2026-09-30 DOI: 10.1038/s41433-026-04872-9

Catharine Kwok, Imran Malik, Helya Aghazadeh, Amr Wassef, Mandeep S Sagoo

{"title":"Patient-reported outcome measures 1 year after conjunctival melanoma treatment using EORTC QLQ-C30 and QLQ-OPT30 questionnaires.","authors":"Catharine Kwok, Imran Malik, Helya Aghazadeh, Amr Wassef, Mandeep S Sagoo","doi":"10.1038/s41433-026-04872-9","DOIUrl":"https://doi.org/10.1038/s41433-026-04872-9","url":null,"abstract":"Objectives: To investigate patient-reported outcome measures (PROMs) in biopsy-confirmed and treated conjunctival melanoma.Methods: Retrospective, cross-sectional observational case series assessing PROMs 1 year after initial treatment. A total of 13 consecutive patients who underwent excision of newly diagnosed conjunctival melanoma between June and December 2023 in a single UK specialized tertiary center met the inclusion criteria. Of these, 11 patients (85%) completed the EORTC QLQ-C30 (Quality of Life of Cancer Patients) and QLQ-OPT30 (Quality of Life of Ophthalmic Cancer Patients) questionnaires. The 60 items assessed general health, ocular symptoms, functional status, psychosocial impacts, overall quality of life and health within the last week. Responses were analysed.Results: Mean scores across the 58 items ranged from 1.00 to 2.18/4 ('not at all 'to 'a little'), indicating an overall mild impact. Patients were slightly limited in activities of daily living but more restricted in pursuing hobbies and social activities, which most did not attribute to their eyesight. Patients reported some symptoms of depression and worry, both generally and related to their health. Common ocular symptoms included: dry eye, watering, difficulty driving in the dark and difficulty judging distances. Overall health in the last week was rated 4.91/7 and overall quality of life was 5.18/7.Conclusions: There is a paucity of research exploring quality of life in treated conjunctival melanoma. These findings can help inform patients and clinicians about potential long-term symptoms, functional difficulties and psychological effects, thereby managing expectations. Consequently, further endeavours can be directed to better support patients with conjunctival melanoma.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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