IF 2.8 3区医学

Eye Pub Date : 2025-05-01 Epub Date: 2025-03-14 DOI: 10.1038/s41433-025-03750-0

Voraporn Chaikitmongkol, Patcharawan Chatromyen, Janejit Choovuthayakorn, Direk Patikulsila, Paisan Ruamviboonsuk, Pichai Jirarattanasopa, Nawat Watanachai, Paradee Kunavisarut, Mansing Ratanasukon, Patama Bhurayanontachai, Neil M Bressler

引用次数: 0

Reply to 'Comment on: Benchmarking the performance of large language models in uveitis: a comparative analysis of ChatGPT-3.5, ChatGPT-4.0, Google Gemini, and Anthropic Claude3'. 回复“评论：对大型语言模型在葡萄膜炎中的性能进行基准测试：ChatGPT-3.5、ChatGPT-4.0、谷歌Gemini和Anthropic Claude3的比较分析”。

IF 2.8 3区医学

Eye Pub Date : 2025-05-01 Epub Date: 2025-03-05 DOI: 10.1038/s41433-025-03737-x

Fang-Fang Zhao, Han-Jie He, Jia-Jian Liang, Ling-Ping Cen

引用次数: 0

Comment on: 'A multifactorial, evidence-based analysis of pathophysiology in Spaceflight Associated Neuro-Ocular Syndrome (SANS)'. 评论：“航天相关神经-眼综合征（SANS）病理生理学的多因素、循证分析”。

IF 2.8 3区医学

Eye Pub Date : 2025-05-01 Epub Date: 2025-02-23 DOI: 10.1038/s41433-025-03727-z

Jay C Buckey, Mimi Lan

引用次数: 0

Correlation between preoperative aqueous cytokine levels and mid-term corneal endothelial cell loss following penetrating keratoplasty. 术前水细胞因子水平与穿透性角膜移植术后中期角膜内皮细胞损失的相关性。

IF 2.8 3区医学

Eye Pub Date : 2025-05-01 Epub Date: 2025-01-20 DOI: 10.1038/s41433-025-03610-x

Hiroshi Matsumae, Kaon Kataoka, Yukari Yagi-Yaguchi, Kazunari Higa, Takanori Suzuki, Hirotsugu Kasamatsu, Jun Shimazaki, Takefumi Yamaguchi

{"title":"Correlation between preoperative aqueous cytokine levels and mid-term corneal endothelial cell loss following penetrating keratoplasty.","authors":"Hiroshi Matsumae, Kaon Kataoka, Yukari Yagi-Yaguchi, Kazunari Higa, Takanori Suzuki, Hirotsugu Kasamatsu, Jun Shimazaki, Takefumi Yamaguchi","doi":"10.1038/s41433-025-03610-x","DOIUrl":"10.1038/s41433-025-03610-x","url":null,"abstract":"Objective: To investigate the association between preoperative aqueous humour (AqH) cytokines and mid-term endothelial cell density (ECD) following penetrating keratoplasty (PKP).Methods: This study analysed a total of 87 eyes of which 54 underwent PKP and 33 eyes underwent cataract surgery. AqH samples were collected at the beginning of surgery. The levels of cytokines (interleukins [ILs]-1α, -1β, -4, -6, -8, -10, -17A, monocyte chemotactic protein [MCP]-1, interferon [IFN]-α, IFN-γ, E-selectin, P-selectin, and soluble intercellular adhesion molecule-1 [sICAM-1]) in the AqH were measured using a multiplex beads immunoassay. The subjects who underwent PKP were classified into two groups: Group 1: ECD < 1200 cells/mm2 at 36 months and graft failure during follow-up (38 eyes); Group 2 ECD ≥ 1200 cells/mm2 at 36 months (16 eyes).Results: The ECD reduction per year was significantly correlated with the preoperative levels of protein (r = 0.48; P < 0.001), IL-6 (r = 0.29; P = 0.048), IL-8 (r = 0.42; P = 0.003), IL-12p70 (r = 0.46; P = .007), MCP-1 (r = 0.28; P = 0.049), IFN -γ (r = 0.43; P = 0.008), and s-ICAM-1 (r = 0.30; P = 0.03). The preoperative levels of IL-8, and IFN-γ in AqH were significantly higher in eyes with ECD < 1200 cells/mm2 compared to those with ECD ≥ 1200 cells/mm2 at 3 years (P ≤ 0.02).Conclusion: Preoperative AqH cytokine levels are associated with mid-term ECD reduction after PKP. Pathological alterations of the AqH microenvironment may affect mid-term corneal endothelial cell survival.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1286-1291"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between normal tension glaucoma and the risk of obstructive sleep apnoea using the STOP-Bang questionnaire. 使用STOP-Bang问卷调查正常紧张性青光眼与阻塞性睡眠呼吸暂停风险的关系

IF 2.8 3区医学

Eye Pub Date : 2025-05-01 Epub Date: 2025-02-10 DOI: 10.1038/s41433-025-03638-z

Eun Jin Koh, Jihei Sara Lee, Chan Yun Kim, Hyoung Won Bae

{"title":"Association between normal tension glaucoma and the risk of obstructive sleep apnoea using the STOP-Bang questionnaire.","authors":"Eun Jin Koh, Jihei Sara Lee, Chan Yun Kim, Hyoung Won Bae","doi":"10.1038/s41433-025-03638-z","DOIUrl":"10.1038/s41433-025-03638-z","url":null,"abstract":"Background: To assess the association between patients with normal tension glaucoma (NTG) and the risk of obstructive sleep apnoea (OSA) using the STOP-Bang questionnaire.Methods: A population-based cross-sectional analysis was performed using data from the Korean National Health and Nutrition Examination Survey from 2019 to 2021. An overall of 8832 subjects ≥ 40 years of age were investigated. Patients with NTG and controls completed the STOP-Bang questionnaire, a validated tool for identifying high-risk patients for OSA. The patients were divided into low-, intermediate-, and high-risk groups based on their scores.Results: The mean STOP-Bang scores were 2.04 ± 0.02 in the control group and 2.42 ± 0.10 in the NTG group, with significant differences between groups (p < 0.001). In univariate logistic regression models, both intermediate-risk (Odds ratio (OR), 1.42; 95% Confidence intervals (CI), 1.05-1.91) and high-risk (OR, 1.71; 95% CI, 1.22-2.40) for OSA groups revealed a significant relationship regarding NTG compared to low-risk for OSA group. When adjusted for all confounding factors, the high risk for the OSA group was significantly associated with NTG (OR, 1.54; 95% CI, 1.06-2.24).Conclusions: Our results indicate that high-risk OSA, as measured using the STOP-Bang questionnaire, correlates with NTG. Therefore, patients who scored two or more on the STOP-Bang questionnaire and were male, had a BMI > 35 or a neck circumference > 40 cm, or those who scored five or more and were classified as high risk should be carefully monitored because of the significantly higher likelihood of an association with NTG.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1420-1425"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and efficacy of a novel 'One-Visit, Both-Cataracts' high-volume see-and-treat immediate sequential bilateral cataract surgery service in a public healthcare setting. 一种新型的“一次就诊，双侧白内障”大容量即时连续双侧白内障手术服务的安全性和有效性。

IF 2.8 3区医学

Eye Pub Date : 2025-05-01 Epub Date: 2025-02-09 DOI: 10.1038/s41433-025-03659-8

Maher Alsusa, Shakeel Ahmad, Zoe Smith, Emma Tutchings, Sam Evans, Elizabeth Wilkinson, Harry Roberts

{"title":"Safety and efficacy of a novel 'One-Visit, Both-Cataracts' high-volume see-and-treat immediate sequential bilateral cataract surgery service in a public healthcare setting.","authors":"Maher Alsusa, Shakeel Ahmad, Zoe Smith, Emma Tutchings, Sam Evans, Elizabeth Wilkinson, Harry Roberts","doi":"10.1038/s41433-025-03659-8","DOIUrl":"10.1038/s41433-025-03659-8","url":null,"abstract":"Purpose: To evaluate the safety and efficacy of a novel cataract surgery pathway that combines a See-and-Treat (S&T) model with Immediate Sequential Bilateral Cataract Surgery (ISBCS) at the Nightingale Hospital, Exeter, UK.Methods: A retrospective observational study was conducted on 102 consecutive patients (204 eyes) who underwent S&T ISBCS between July 2023 and July 2024. Patients were triaged based on referral information and underwent preoperative telephone consultations. On the day of surgery, clinical assessment and bilateral cataract surgery were completed in a single visit. Data collected included patient demographics, intraoperative and postoperative outcomes, and complications.Results: Of the 127 patients listed, 102 (84.3%) completed S&T ISBCS. No intraoperative complications were recorded. Fourteen patients (13.7%) required unplanned postoperative consultations, with most cases being non-sight-threatening and self-resolving. Cystoid macular oedema (CMO) was reported in 2.9% of eyes, with no cases of visual loss or endophthalmitis.Conclusion: The S&T ISBCS model demonstrated safety and efficiency in delivering cataract care, with a high one-visit completion rate and low complication rates. This model offers significant time and resource savings whilst maintaining patient safety. It holds potential for broader implementation in healthcare settings facing increased demand for cataract services. Further studies are recommended to assess long-term outcomes and optimise this approach.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1414-1419"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fundus vascular arcades angle reflects choroidal thickness in highly myopic children and adolescents. 高度近视儿童及青少年眼底血管拱廊角反映脉络膜厚度。

IF 2.8 3区医学

Eye Pub Date : 2025-05-01 Epub Date: 2025-01-18 DOI: 10.1038/s41433-025-03604-9

Wei Gong, Bo Zhang, Dengji Zhou, Saiguang Ling, Jinliuxing Yang, Jun Chen, Jingjing Wang, Xun Xu, Xiangui He, Wei Gao

{"title":"Fundus vascular arcades angle reflects choroidal thickness in highly myopic children and adolescents.","authors":"Wei Gong, Bo Zhang, Dengji Zhou, Saiguang Ling, Jinliuxing Yang, Jun Chen, Jingjing Wang, Xun Xu, Xiangui He, Wei Gao","doi":"10.1038/s41433-025-03604-9","DOIUrl":"10.1038/s41433-025-03604-9","url":null,"abstract":"Objectives: To identify the role of fundus vascular arcades angle (VAA) in reflecting choroidal thickness (ChT) of highly myopic children and adolescents.Methods: Participants aged 5 to 18 yrs with high myopia (spherical equivalent, SE ≤ -5.0 D) were enrolled and followed up for one year from the Shanghai Child and Adolescent Large-scale Eye Study. The VAA in the range of one papillary diameter (PD) as well as 2PD away from the central point of optic disc was recognized and measured by artificial intelligence from fundus photographs.Results: Finally, 277 highly myopic participants were included in the analysis. The mean VAA (1PD) was 128.38 ± 9.56°, and the mean VAA (2PD) was 110.25 ± 11.97°. For those with larger VAA, the choroidal thickness around macula (mChT) or papillary (pChT) was thicker (P for trend < 0.05). After adjusting for age and gender, thinner ChT was independently associated with smaller VAA (P < 0.001). For those with more decrease of VAA, the thinning of ChT was more remarkable (P < 0.05). In the regression analysis, more change of pChT was independently associated with more change of VAA (P < 0.01). After adjusting for other related parameters, 1°change of VAA (1PD) or VAA (2PD) accounted for 0.855 mm or 0.719 mm change of pChT.Conclusions: Fundus VAA was closely associated with choroidal thickness in highly myopic paediatric population. It could serve as an alternative indicator of choroid thickness in the fundus screening for evaluating the risk of pathological changes of high myopia.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1264-1269"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What have we learned from a decade treating patients with diabetic macular oedema with 0.19 mg fluocinolone acetonide intravitreal implant? 10年来，我们用0.19 mg醋酸氟西诺酮玻璃体内植入治疗糖尿病性黄斑水肿患者，从中我们学到了什么？

IF 2.8 3区医学

Eye Pub Date : 2025-05-01 Epub Date: 2025-02-19 DOI: 10.1038/s41433-025-03692-7

Laurent Kodjikian, Lilianne Duarte, Pankaj Singh, Maged Habib, Victor Gonzalez

{"title":"What have we learned from a decade treating patients with diabetic macular oedema with 0.19 mg fluocinolone acetonide intravitreal implant?","authors":"Laurent Kodjikian, Lilianne Duarte, Pankaj Singh, Maged Habib, Victor Gonzalez","doi":"10.1038/s41433-025-03692-7","DOIUrl":"10.1038/s41433-025-03692-7","url":null,"abstract":"Diabetic macular oedema [DMO] is a prevalent and sight-threatening condition among diabetic patients, which can cause irreversible blindness. Since angiogenesis and inflammation are two key elements in the etiopathogenesis of DMO, intravitreal injections of vascular endothelial growth factor inhibitors [anti-VEGF] and sustained released intravitreal corticosteroid implants are currently considered as treatments of choice. The introduction, 10 years ago, of the 0.19 mg fluocinolone acetonide [FAc] implant for treating eyes with vision impairment associated with recurrent and persistent DMO represented an important advance. Since then, two randomized-control trials and many real-world studies have shown its good efficacy/safety profile and the replicability of its treatment regimen. The FAc implant is, in general terms well tolerated, although it is associated with intraocular pressure-[IOP] and cataract-related adverse events [AEs]. Most IOP-related AEs are effectively controlled with ocular-hypotensive therapies. The objective of this paper is to review the role of FAc implant in the treatment of DMO over the 10 years since its launch, as well as its impact on clinical practice outcomes.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1238-1248"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044149/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging perspectives in quality of life after trabeculectomy surgery. 小梁切除术后生活质量的新观点。

IF 2.8 3区医学

Eye Pub Date : 2025-05-01 Epub Date: 2025-02-08 DOI: 10.1038/s41433-025-03636-1

Ricardo D S Peixoto, Francesco Stringa, Renee Cammack, Joanna Liput, Anthony J King

{"title":"Emerging perspectives in quality of life after trabeculectomy surgery.","authors":"Ricardo D S Peixoto, Francesco Stringa, Renee Cammack, Joanna Liput, Anthony J King","doi":"10.1038/s41433-025-03636-1","DOIUrl":"10.1038/s41433-025-03636-1","url":null,"abstract":"Background/objectives: Trabeculectomy is the gold standard surgery in treatment of glaucoma but there is little reported on its early impact in health-related quality of life (HRQoL). Here we characterise HRQoL in the early post-operative period with two generic patient-reported outcome measures tools (PROMs), the EQ-5D and SF-6D, and compare them to visual-related and glaucoma-specific PROMs, the VF-25 and GUI.Subjects/methods: We prospectively enrolled 168 patients with failed medical treatment undergoing trabeculectomy and assessed HRQoL at baseline and in the post-operative period using the PROMs above. Paired t-tests, ANOVA and linear regression tests were used to analyse outcomes.Results: A significant drop in HRQoL was identified in the first month post-operatively with the SF-6D, the VF-25 and the GUI but not with the EQ-5D. This drop was reversed to pre-operative levels by month 3. Four dimensions of HRQoL, including physical functioning, social functioning and adaptation to physical and to emotional roles had the most impact on the generic HRQoL. Visual acuity dropped one line in the operated eye at month 1 and was the only measurable clinical factor contributing to HRQoL.Conclusions: The early post-operative period in trabeculectomy surgery is associated with a reversible loss of HRQoL, which is the result of transient worsening of vision but also physical, emotional and social restrictions caused by the busy medication regimen and drastic lifestyle changes. The SF-6D was better than the EQ-5D at picking up changes in HRQoL.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1394-1399"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Markov model assessing the cost-effectiveness of various anti-vascular endothelial growth factor drugs and panretinal photocoagulation for the treatment of proliferative diabetic retinopathy. 评估各种抗血管内皮生长因子药物和全视网膜光凝治疗增殖性糖尿病视网膜病变的成本效益的马尔可夫模型。

IF 2.8 3区医学

Eye Pub Date : 2025-05-01 Epub Date: 2025-02-05 DOI: 10.1038/s41433-025-03641-4

Kirsty Luckham, Hannah Tebbs, Lindsay Claxton, Philip Burgess, Christiana Dinah, Noemi Lois, Syed Mohiuddin

{"title":"A Markov model assessing the cost-effectiveness of various anti-vascular endothelial growth factor drugs and panretinal photocoagulation for the treatment of proliferative diabetic retinopathy.","authors":"Kirsty Luckham, Hannah Tebbs, Lindsay Claxton, Philip Burgess, Christiana Dinah, Noemi Lois, Syed Mohiuddin","doi":"10.1038/s41433-025-03641-4","DOIUrl":"10.1038/s41433-025-03641-4","url":null,"abstract":"Background: Proliferative diabetic retinopathy (PDR) may lead to vision loss and blindness. The cost-effectiveness of various anti-vascular endothelial growth factor (anti-VEGF) drugs and panretinal photocoagulation (PRP) was assessed to supplement the NICE guideline for treating PDR.Methods: A Markov model including eight levels of visual acuity (ranged between >85 and ≤25 letters) was developed to compare the cost-effectiveness of ranibizumab, aflibercept and bevacizumab with PRP (alone or in combination). Clinical inputs in the model were based on literature, while a published network meta-analysis (NMA) informed visual outcomes. Costs were estimated from a UK NHS perspective.Results: Assuming initial treatment effects from the NMA continued to be applied for the remainder of lifetime, the probabilistic analysis resulted in bevacizumab plus PRP producing the highest net monetary benefit (NMB [95% CI]) of £221,374 [£203,941-£238,388] at £20,000 per quality-adjusted life-year. However, assuming initial treatment effects stabilised over time resulted in PRP alone producing the highest NMB of £223,416 [£209,318-£236,866]. Results were associated with large uncertainty due to wide confidence intervals around vision-based treatment effects of anti-VEGFs versus PRP, particularly for bevacizumab as data were drawn from trials with small sample size and high risk of bias. Using confidential prices for aflibercept and ranibizumab did not change the overall findings.Conclusions: PRP is likely to be more cost-effective than anti-VEGFs for PDR. However, the results should be interpreted with caution given the scarcity of long-term visual outcomes with anti-VEGFs in this population. Further research on long-term visual outcomes may resolve these uncertainties.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1364-1372"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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