EyePub Date : 2025-03-05DOI: 10.1038/s41433-025-03680-x
Chen Chen, Haoming Gao, Xiuli Guo, Wei Wei
{"title":"Enhancing the understanding of anti-VEGF treatment failure in retinal vascular diseases: a call for expanded analyses and threshold validation","authors":"Chen Chen, Haoming Gao, Xiuli Guo, Wei Wei","doi":"10.1038/s41433-025-03680-x","DOIUrl":"10.1038/s41433-025-03680-x","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":"39 6","pages":"1229-1229"},"PeriodicalIF":2.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reply to 'Comment on: Benchmarking the performance of large language models in uveitis: a comparative analysis of ChatGPT-3.5, ChatGPT-4.0, Google Gemini, and Anthropic Claude3'.","authors":"Fang-Fang Zhao, Han-Jie He, Jia-Jian Liang, Ling-Ping Cen","doi":"10.1038/s41433-025-03737-x","DOIUrl":"https://doi.org/10.1038/s41433-025-03737-x","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EyePub Date : 2025-03-04DOI: 10.1038/s41433-025-03695-4
Jamie A Yule, Virginija Vilkelyte, Shakeel Ahmad, Poonam Sharma, James Myerscough, Stephen Kaye, Harry W Roberts
{"title":"Correction: UK corneal surgeons' attitudes towards splitting donor corneas between multiple recipients.","authors":"Jamie A Yule, Virginija Vilkelyte, Shakeel Ahmad, Poonam Sharma, James Myerscough, Stephen Kaye, Harry W Roberts","doi":"10.1038/s41433-025-03695-4","DOIUrl":"https://doi.org/10.1038/s41433-025-03695-4","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction: Validation and optimization of smart eye camera as teleophthalmology device for the reduction of preventable and treatable blindness in Nigeria","authors":"Ayodele Jacob Orugun, Mayor Orezime Atima, Ugbede Idakwo, Oyeronke Komolafe, Kehinde Kabir Oladigbolu, Elijah Peter, Halima Olufunmilola Abdulsalam, Emamoke Atima-Ayeni, Emeka John Dingwoke, Rohan Khemlani, Shintaro Nakayama, Eisuke Shimizu, Emmanuel Oluwadare Balogun","doi":"10.1038/s41433-025-03654-z","DOIUrl":"10.1038/s41433-025-03654-z","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":"39 5","pages":"1-1"},"PeriodicalIF":2.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41433-025-03654-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EyePub Date : 2025-03-03DOI: 10.1038/s41433-025-03701-9
Mohideen Abdul Kader, Madhavi Ramanatha Pillai, Rinkal Goyal, Allapitchai Fathima
{"title":"Reversal of hypotony maculopathy following traumatic cyclodialysis: a ring of hope.","authors":"Mohideen Abdul Kader, Madhavi Ramanatha Pillai, Rinkal Goyal, Allapitchai Fathima","doi":"10.1038/s41433-025-03701-9","DOIUrl":"10.1038/s41433-025-03701-9","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EyePub Date : 2025-02-28DOI: 10.1038/s41433-025-03725-1
Stanley S J Poh, Kelvin Y C Teo, Rose Ann Goh, Qian Xin Lee, Haslina Hamzah, Serene S C Sim, Colin S Tan, Ngiap Chuan Tan, Tien Yin Wong, Gavin S W Tan
{"title":"Predicting the need for diabetic macular oedema treatment from photographic screening in the Singapore Integrated Diabetic Retinopathy Programme (SiDRP).","authors":"Stanley S J Poh, Kelvin Y C Teo, Rose Ann Goh, Qian Xin Lee, Haslina Hamzah, Serene S C Sim, Colin S Tan, Ngiap Chuan Tan, Tien Yin Wong, Gavin S W Tan","doi":"10.1038/s41433-025-03725-1","DOIUrl":"10.1038/s41433-025-03725-1","url":null,"abstract":"<p><strong>Objective: </strong>To identify diabetic maculopathy features from photographic screening that are predictive of treatment on referral to a tertiary care centre.</p><p><strong>Methods: </strong>Retrospective review of participants who underwent screening by Singapore Integrated Diabetic Retinopathy Programme from 2015 to 2019. Participants underwent visual acuity (VA) test and non-stereoscopic retinal photographs. Maculopathy features include haemorrhages, microaneurysm and hard exudates (HE), stratified by inner and outer zone (1 and 1-2 disc diameter from fovea respectively) and VA of 6/12. Diabetic macular oedema (DMO) treatment was defined as intravitreal injection or macular photocoagulation up to 540 days from point of referral.</p><p><strong>Results: </strong>16,712 patients screened had referable eye disease. Out of 3518 maculopathy suspects, 281 (8.0%) received DMO treatment within 540 days. Those treated for DMO had shorter duration of diabetes (6.90 vs. 9.13 years, p < 0.001), higher total cholesterol (4.65 ± 1.20 vs. 4.36 ± 1.13 mmol/L, p = 0.001) and LDL cholesterol (2.59 ± 1.05 vs. 2.37 ± 0.93 mmol/L, p < 0.05) than those without treatment. High-risk features, including inner zone haemorrhages with VA ≤ 6/12 (HR 12.0, 95% CI: 5.5-25.9) and inner zone hard exudates (HR 7.4, 95% CI: 3.4-15.8), significantly increased the likelihood of requiring DMO treatment compared to low-risk features. Higher body mass index is protective of DMO treatment in mild non-proliferative diabetic retinopathy (HR 0.84, 95% CI: 0.73-0.97).</p><p><strong>Conclusion: </strong>Haemorrhages, microaneurysms and HE within inner zone are important photographic features predictive of DMO treatment. VA is an important stratification for screening especially in patients with only visible haemorrhages.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EyePub Date : 2025-02-28DOI: 10.1038/s41433-025-03712-6
Margarita Safir, Itay Nitzan, Yair Hanina, Ari Safir, Eliya Levinger, Dan Heller, Nir Sorkin
{"title":"Atopic disease and astigmatism: a population-based study.","authors":"Margarita Safir, Itay Nitzan, Yair Hanina, Ari Safir, Eliya Levinger, Dan Heller, Nir Sorkin","doi":"10.1038/s41433-025-03712-6","DOIUrl":"10.1038/s41433-025-03712-6","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the relationship between atopic disease and astigmatism in adolescence and young adulthood.</p><p><strong>Methods: </strong>In this population-based cross-sectional study 897,811 medical records of Israeli adolescents and young adults without keratoconus were reviewed. The prevalence of low-to-moderate (3.00 > D ≥ 0.75) and high ( ≥ 3.00 D) astigmatism were calculated in cases with and without atopic disease, including ocular atopic disease (OAD), asthma, allergic rhinitis, atopic dermatitis, angioedema/urticaria, and history of anaphylaxis. Relationships were analysed using multinominal logistic regression, with adjustments for relevant sociodemographic factors.</p><p><strong>Results: </strong>A total of 897,811 adolescents were included in the analysis (mean age 17.2 ± 0.8 years, 57.8% men). OAD was found in 4702 individuals, with a prevalence of 0.5%. Adolescents with OAD demonstrated a gradual increase in odds ratio (OR) for low-to-moderate and for high astigmatism (OR 1.16, 95% CI 1.07-1.27 and OR 2.10, 95% CI 1.63-2.70, respectively). This group also showed increased OR for with-the-rule astigmatism (OR 1.34, 95% CI 1.21-1.48). Other atopic diseases were associated with more modest ORs for low-to-moderate (OR 1.09, 95% CI 1.07-1.11) and for high astigmatism (OR 1.10, 95% CI 1.02-1.19), persisting across all axis orientations. Sensitivity analysis revealed a dose-response relationship between OAD severity and astigmatism, and consistent point estimates in a group of 1331 adolescents diagnosed with OAD during military service.</p><p><strong>Conclusions: </strong>This study establishes an association between OAD and astigmatism, highlighting the importance of effective OAD management. Further research into tailored therapeutic interventions that address both conditions concurrently is needed.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}