Eye最新文献

{"title":"Bilateral progressive myelinated retinal nerve fibres.","authors":"Sean Lazaro, Daniel Lamoureux, Susan Mollan","doi":"10.1038/s41433-026-04865-8","DOIUrl":"https://doi.org/10.1038/s41433-026-04865-8","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between choroidal structure and retinal fluid location in type 1 neovascular age-related macular degeneration.","authors":"Valentina Bilbao-Malavé, Miriam de la Puente, Leyre Ochoa-Tejada, Cristina Irigoyen Bañegil, Alexander Anduaga-Beramendi, María Fraga de la Viesca, Sara Llorente-González, Manuel Sáenz de Viteri, María Hernández, Henar Heras-Mulero, Luis Arias-Barquet, Alfredo García-Layana, Sergio Recalde, Jorge González-Zamora","doi":"10.1038/s41433-026-04825-2","DOIUrl":"https://doi.org/10.1038/s41433-026-04825-2","url":null,"abstract":"<p><strong>Objectives: </strong>To correlate choroidal structure parameters with the presence and amount of subretinal fluid (SRF) and intraretinal fluid (IRF) in treatment-naïve neovascular age-related macular degeneration (nAMD) patients with type 1 macular neovascularisation (MNV).</p><p><strong>Methods: </strong>A retrospective study reviewed clinical records of 96 patients diagnosed with nAMD between 2015 and 2022. Optical coherence tomography (OCT) scans were analysed for choroidal thickness, choroidal vascularity index (CVI), and large choroidal vessel index (LCVI) using ImageJ software with automated binarisation. SRF was manually quantified using embedded OCT tools, and IRF volume was measured using an artificial intelligence-based platform. Patients with type 1 MNV (n = 56) were included for fluid-choroidal correlations. Statistical analyses included t-tests, Mann-Whitney U tests, and Spearman correlations (p < 0.05).</p><p><strong>Results: </strong>In type 1 MNV eyes, SRF presence was associated with greater choroidal thickness (p = 0.03), and SRF area correlated positively with choroidal thickness (p = 0.02) and foveal LCVI (p = 0.004). Maximum SRF height correlated with foveal LCVI (p = 0.007). IRF presence was linked to reduced choroidal thickness (p = 0.0008), and IRF volume inversely correlated with choroidal thickness (p = 0.01) and macular LCVI (p = 0.002). No significant choroidal changes were observed pre-MNV or compared to fellow eyes.</p><p><strong>Conclusions: </strong>In treatment-naïve type 1 MNV, choroidal thickness and LCVI exhibit opposite associations with subretinal and intraretinal fluid, emphasising distinct pathophysiological mechanisms: choroidal venous overload may be associated with SRF accumulation, while choroidal thinning may be implicated in IRF formation. These findings may help generate hypothesis regarding variability in anti-VEGF treatment response and suggest that choroidal characteristics warrant further investigation as potential biomarkers for future individualised management strategies.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endophthalmitis following glaucoma drainage device surgery.","authors":"Abdelrahman M Elhusseiny, Ahmad F Alzein, Qais A Dihan, Hashem Abu Serhan, Aron M Sebhat, Reem H ElSheikh, Jawad Muayad, Nicolas A Yannuzzi, Elena Bitrian, Ta C Chang","doi":"10.1038/s41433-026-04876-5","DOIUrl":"https://doi.org/10.1038/s41433-026-04876-5","url":null,"abstract":"<p><strong>Background: </strong>To evaluate the risk of endophthalmitis in glaucoma patients undergoing glaucoma drainage device (GDD) surgery.</p><p><strong>Methods: </strong>This retrospective cohort study identified glaucoma patients utilising TriNetX's database who underwent GDD between 2004 and 2024 without a prior history of glaucoma surgery. Kaplan-Meier survival analysis estimated the cumulative incidence of endophthalmitis and a Cox proportional hazards model, adjusted for demographic and clinical covariates, was used to calculate adjusted hazard ratios (aHRs) and confidence intervals (CIs) comparing outcomes between patients who underwent tube shunt surgery versus trabeculectomy. A scleral buckle (SB) cohort was added as a second comparator to GDD to contextualise infection risk related to hardware without bleb formation.</p><p><strong>Results: </strong>The GDD cohort included 12,849 patients (mean age 62.7 ± 19 years), compared with 9,006 trabeculectomy patients (67.9 ± 14.1) and 3,097 SB patients (45.1 ± 18.7). After GDD surgery, the cumulative incidence of endophthalmitis was 0.82% at 1, 1.57% at 3 and 1.87% at 5 years, compared with 0.47%, 0.78% and 0.96% following trabeculectomy and 0.19%, 0.23% and 0.39% following SB. In Cox models, there was no significant difference in hazard between GDD and trabeculectomy at any timepoint. However, GDD was associated with higher risk than SB at 30 days (aHR 5.43, CI: 1.28-23.08, 1 year (aHR 3.36, 95% CI 1.88-5.99) and 5 years (aHR 3.71, 95% CI 2.40-5.73).</p><p><strong>Conclusion: </strong>Endophthalmitis is an uncommon but persistent risk after GDD surgery. Although long-term risk was comparable between GDD and trabeculectomy, GDD implantation carried a higher risk than SB.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the letter to the editor- phase III trials in retinal biosimilars: parity before pragmatism.","authors":"Ashish Sharma, Baruch D Kuppermann","doi":"10.1038/s41433-026-04925-z","DOIUrl":"https://doi.org/10.1038/s41433-026-04925-z","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ophthalmomyiasis in a child: a diagnostic pitfall.","authors":"Aparna Dwibedy, Amit Bidasaria, Anjalika Parhi","doi":"10.1038/s41433-026-04877-4","DOIUrl":"https://doi.org/10.1038/s41433-026-04877-4","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149015713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Best disease with a lamellar twist.","authors":"Abhishek Das, Ashitha Ezhuthuppalli, Parag K Shah","doi":"10.1038/s41433-026-04895-2","DOIUrl":"https://doi.org/10.1038/s41433-026-04895-2","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clustered sterile intraocular inflammation following intravitreal aflibercept injections: involvement of 2 mg, 8 mg, and biosimilar formulations.","authors":"Yong-Yeon Song, Youngdon Kim, Young Taek Chung","doi":"10.1038/s41433-026-04864-9","DOIUrl":"https://doi.org/10.1038/s41433-026-04864-9","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct postoperative anatomical outcomes between lamellar macular holes and epiretinal membrane foveoschisis.","authors":"Marion Lam, Elise Philippakis, Ali Erginay, Alain Gaudric, Aude Couturier","doi":"10.1038/s41433-026-04857-8","DOIUrl":"https://doi.org/10.1038/s41433-026-04857-8","url":null,"abstract":"<p><strong>Background: </strong>To compare the postoperative anatomical outcomes between eyes with lamellar macular hole (LMH), epiretinal membrane foveoschisis (ERM-FS) and macular pseudohole (MPH).</p><p><strong>Methods: </strong>A retrospective single-centre study, including patients operated for LMH, ERM-FS or MPH, was conducted in a tertiary care centre in Paris, France. LMH eyes underwent vitrectomy with epiretinal proliferation peeling and tamponade, while ERM-FS and MPH eyes underwent ERM peeling without tamponade.</p><p><strong>Results: </strong>Eighty-three eyes were included with a mean follow-up of 10.4 months: 16 with LMH, 50 with ERM-FS, and 17 with MPH. The mean preoperative central macular thickness (CMT) in LMH eyes (300 ± 43 µm) was thinner than normal and significantly differed from that in ERM-FS and MPH eyes (425 ± 80 µm vs. 380 ± 81 µm, p < 0.0001 and p = 0.02, respectively), which were thicker than normal. In LMH eyes, the mean postoperative CMT remained stable (285 ± 35 µm, p = 0.2) and thinner than in ERM-FS eyes, which was significantly decreased to 371 ± 46 µm (p < 0.0001). The mean postoperative central foveal thickness was significantly increased in ERM-FS eyes (from 191 to 271 µm, p < 0.0001) and in MPH eyes (from 189 to 288 µm, p < 0.0006), while stable compared to before surgery in LMH eyes (141 and 165 µm, p = 0.11) and thinner than normal.</p><p><strong>Conclusions: </strong>Lamellar macular hole is a distinct vitreoretinal interface disorder from ERM-FS, with different anatomical postoperative outcomes. Eyes with LMH can improve vision after vitrectomy but its surgical management may differ from that of ERM-FS.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient intraocular lens opacification after intravitreal triamcinolone injection.","authors":"Pedro Cardoso-Teixeira, Lilianne Duarte, Cláudia Costa Ferreira","doi":"10.1038/s41433-026-04878-3","DOIUrl":"https://doi.org/10.1038/s41433-026-04878-3","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultra‑widefield imaging for retinal breaks: is it time for a head‑to‑head comparison with preoperative examination?","authors":"Liling Yu","doi":"10.1038/s41433-026-04879-2","DOIUrl":"https://doi.org/10.1038/s41433-026-04879-2","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}