Eye最新文献

{"title":"Response to: 'Comment on 'Metagenomic next-generation sequencing: a game changer in the diagnosis of unique intraocular infections''.","authors":"Zohar Habot-Wilner, Michael Ostrovsky, Dinah Zur, Shulamit Schwartz, David Hagin, Avi Gadoth, Ronen Ben-Ami, Yael Paran, Hanoch Goldshmidt, Matan Slutzkin, Amos Adler, Katya Levytskyi","doi":"10.1038/s41433-026-04434-z","DOIUrl":"https://doi.org/10.1038/s41433-026-04434-z","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147527874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pachychoroid pigment epitheliopathy: long-term structural changes and risk factors for disease evolution.","authors":"Federica Lo Cascio, Gabriele Monici, Chiara Olivieri, Francesco Petrillo, Paola Marolo, Pasquale Viggiano, Francesco Boscia, Michele Reibaldi, Enrico Borrelli","doi":"10.1038/s41433-026-04410-7","DOIUrl":"https://doi.org/10.1038/s41433-026-04410-7","url":null,"abstract":"<p><strong>Purpose: </strong>Pachychoroid pigment epitheliopathy (PPE) is an early, often asymptomatic stage of the pachychoroid disease spectrum that may progress to central serous chorioretinopathy (CSC), pachychoroid neovasculopathy, or polypoidal choroidal vasculopathy. This study evaluated longitudinal changes in retinal pigment epithelium (RPE) lesions in PPE and identified baseline predictors.</p><p><strong>Design: </strong>Retrospective cohort study.</p><p><strong>Participants: </strong>Forty-five eyes (45 patients) with PPE.</p><p><strong>Methods: </strong>All patients underwent multimodal imaging, including near-infrared reflectance, optical coherence tomography (OCT), blue fundus autofluorescence, and OCT angiography. RPE alteration areas were quantified by projecting OCT B-scan delineations onto near-infrared images. Central subfield thickness (CST) and central choroidal thickness (CCT) were measured, along with choroidal thickness at four quadrants 500 µm and 1000 µm from the foveal centre.</p><p><strong>Main outcome measures: </strong>Change in total RPE lesion area at 1-year follow-up and baseline predictors of lesion progression.</p><p><strong>Results: </strong>At 1 year, total RPE lesion area increased significantly (median 0.81 mm² vs. 0.71 mm² at baseline; p < 0.001), with a median percentage increase of 10.5%. The number of discrete lesions remained unchanged. CST and CCT showed no significant longitudinal changes. Preliminary 2-year data (n = 13) demonstrated similar trends. Multivariable regression identified greater baseline CCT as independently associated with increased RPE lesion progression, whereas smaller baseline RPE areas were associated with a greater relative increase.</p><p><strong>Conclusions: </strong>PPE demonstrates progressive RPE alterations over time despite stable retinal and choroidal thickness. Greater baseline choroidal thickness and limited initial RPE involvement predict faster lesion expansion, supporting PPE as an active and evolving condition requiring regular multimodal monitoring.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147520317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Royal College of Ophthalmologists National Ophthalmology Database age-related macular degeneration (AMD) audit: report 1, associations with socio-economic deprivation in neovascular AMD.","authors":"Riddhi Shenoy, Mable T Monachan, Marta Gruszka-Goh, Martin McKibbin","doi":"10.1038/s41433-026-04382-8","DOIUrl":"10.1038/s41433-026-04382-8","url":null,"abstract":"<p><strong>Background: </strong>Early diagnosis and treatment of neovascular age-related macular degeneration (NvAMD) improve vision outcomes. This analysis investigates associations of English indices of multiple deprivation 2019 (IMD2019) with baseline characteristics, key care processes and visual acuity (VA) outcomes for NvAMD in the National Ophthalmology Database (NOD).</p><p><strong>Methods: </strong>Eligible eyes started treatment for NvAMD in England between 01/04/2020 and 31/03/2023. Participating centres with ≥25 eyes with baseline VA and IMD2019 data were included.</p><p><strong>Results: </strong>Eligible for analysis were 48,583 eyes from 60 English centres. Between decile 1 (most deprived) and decile 10 (least deprived), median age at start of treatment ranged from 79 to 82 years and median baseline VA ranged from 56 to 60 ETDRS letters. After one year of treatment (-28 to +84 days), the median number of injections administered ranged from 7 to 8 across deciles. Loss to follow-up was observed in 13.7% eyes in decile 1, and 11.8% in decile 10. Median VA at 12 months ranged from 61 to 65 ETDRS letters across deciles. A \"good\" VA outcome (≥70 ETDRS letters) was achieved by 45.5% in decile 10, compared with 35.9% observed in decile 1 (p < 0.001). A \"poor\" VA outcome (≥10 ETDRS letter loss from baseline) occurred in 18.4% of eyes in decile 1 versus 14.5% in decile 10 (p < 0.001).</p><p><strong>Conclusions: </strong>Patients starting NHS-funded treatment in England for NvAMD and living in areas of higher socioeconomic deprivation were typically younger, had lower baseline acuity and achieved worse VA outcomes than those from lower deprivation areas, with little variation in treatment between the deciles.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cannula detachment-a solution to a significant patient safety and health economic issue.","authors":"Amar Alwitry","doi":"10.1038/s41433-026-04428-x","DOIUrl":"https://doi.org/10.1038/s41433-026-04428-x","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifocal choroiditis on ICGA.","authors":"Mohd Afzal, Sanjay Kumar Mishra, Alok Sati","doi":"10.1038/s41433-026-04427-y","DOIUrl":"https://doi.org/10.1038/s41433-026-04427-y","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unilateral multiple retinal cysts combined with retinal detachment.","authors":"Fei-E Zhang, Lei-Bing Ji","doi":"10.1038/s41433-026-04429-w","DOIUrl":"https://doi.org/10.1038/s41433-026-04429-w","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147510840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infographic: AREDS¹&AREDS²-oral supplementation with antioxidants for age-related macular degeneration (AMD).","authors":"Darshigaa Gurumoorthy, Eleonora Riotto, Livia Faes, Kimberly Spooner, Dun Jack Fu","doi":"10.1038/s41433-026-04392-6","DOIUrl":"https://doi.org/10.1038/s41433-026-04392-6","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology, aetiology and outcomes of paediatric ocular trauma: a population-level study in Northern Ireland.","authors":"Michael Marshall, Mohammad Anwar, Tim Patterson, Eibhlin McLoone, Clare Shute","doi":"10.1038/s41433-026-04406-3","DOIUrl":"https://doi.org/10.1038/s41433-026-04406-3","url":null,"abstract":"<p><strong>Background and objectives: </strong>Ocular trauma is a major cause of blindness. The objectives of this study were to report epidemiology, aetiology, visual outcomes, and interactions with ophthalmology services of paediatric ocular trauma patients.</p><p><strong>Methods: </strong>A retrospective review of consecutive paediatric ocular trauma presentations between 01 January 2017 and 31 December 2019, within the Belfast Trust. Patients were younger than 16 years old at presentation.</p><p><strong>Results: </strong>In total, 535 paediatric ocular trauma patients are reported. Epidemiology-Median age was 8.18 years old, with 63.8% of patients being male. Incidence was 0.45 cases per 1000 children aged 0-15, per year. Areas were ranked according to deprivation measures, incidence ranged from 0.43 in the 2nd quintile to 0.64 in the quintile with lowest deprivation measures. Aetiology-Blunt (n = 277, 52%), chemical (n = 96, 18%), sharp (n = 87, 16%), and laser injuries (n = 27, 5%) were the most common mechanisms. There were 2 open globe injuries reported (1.7 per 1,000,000 children aged 0-15, per year). Visual outcomes-Visual acuity at presentation was available for 408 eyes (72%), with 174 (43%) achieving 6/6 or better and 338 (83%) 6/12 or better. 6 eyes (3%) presented with vision worse than 6/60; three improved to better than 6/12 at follow-up, and two remained worse than 6/60. Ophthalmology services-16 patients (3.0%) were admitted.</p><p><strong>Conclusions: </strong>Paediatric ocular trauma occurs most commonly in males, in the home setting, with a blunt injury mechanism. Chemical and laser eye mechanisms contribute a significant proportion of presentations.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Highland environment and genetic background are associated with myopia risk in Tibetans and Hans.","authors":"Xiaoman Li, Jiahua Chen, Xiaoyue Hu, Yuanyuan Liu, Na Lin, Guangyun Mao, Yuanbo Liang, Zi-Bing Jin, Chi Pui Pang, Lizhong Wang, Jia Qu, Jie Chen, Fan Lu","doi":"10.1038/s41433-026-04370-y","DOIUrl":"https://doi.org/10.1038/s41433-026-04370-y","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate the relationship of high-altitude environmental features and ethnic Tibetan background with myopia.</p><p><strong>Methods: </strong>This cross-sectional study was conducted at highland and lowland sites. The highland sites were located on the Chinese Tibetan Plateau, approximately 4000 m above sea level. A total of 3634 Tibetans and 377 Hans were included in the highland group. The lowland group was from the Yaoxi community, in Wenzhou City, located 10-20 m above sea level, where 176 Han individuals were included. Non-cycloplegic spherical equivalent refraction (SER) and biochemical function tests were measured.</p><p><strong>Results: </strong>Age-specific myopia prevalence was highest in highland Hans, followed by lowland Hans and highland Tibetans. Among participants in the highland group, including Tibetans and Hans, increased risk of moderate and high myopia was associated with gender [OR (95% CI): 0.47 (0.23, 0.97) for females], education level [OR (95% CI): 3.62 (1.76, 7.45) for middle school education and above], and elevated mean haemoglobin per red blood cell (MCH) [OR (95% CI): 8.04 (1.04, 62.34)]. Among Han participants in both groups, only elevated mean corpuscular volume (MCV) [OR (95% CI): 5.91 (1.00, 34.92)] was associated with increased risk of moderate and high myopia.</p><p><strong>Conclusions: </strong>The higher prevalence of myopia in Hans compared to Tibetans, and in highland Hans compared to lowland Hans, suggests that both ethnicity and high-altitude environment influence myopia development, potentially through gene-environment interactions. Elevated MCV and MCH levels, particularly in highland Hans, may serve as biomarkers for risk, warranting further investigation.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An unusual corneal vascularisation with limbal xerosis in a newborn.","authors":"Anand Kumar Pathak, Arnav Panigrahi, Viney Gupta","doi":"10.1038/s41433-026-04426-z","DOIUrl":"https://doi.org/10.1038/s41433-026-04426-z","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147503600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}