IF 2.8 3区医学

Eye Pub Date : 2024-11-19 DOI: 10.1038/s41433-024-03469-4

Deeksha Rani, Hemant Kumar Raina, Devesh Kumawat

引用次数: 0

Retinoblastoma programme outcome over a 10-year period in Lebanon: assessment of potential impact of the pandemic and economic crisis. 黎巴嫩视网膜母细胞瘤十年计划成果：评估大流行病和经济危机的潜在影响。

IF 2.8 3区医学

Eye Pub Date : 2024-11-19 DOI: 10.1038/s41433-024-03465-8

Christiane Al-Haddad, Zahi Wehbi, Andre Slim, Ali Hmede, Wajiha Jurdi Kheir, Raya Saab, Cosette Nawfal, Elie Bechara

{"title":"Retinoblastoma programme outcome over a 10-year period in Lebanon: assessment of potential impact of the pandemic and economic crisis.","authors":"Christiane Al-Haddad, Zahi Wehbi, Andre Slim, Ali Hmede, Wajiha Jurdi Kheir, Raya Saab, Cosette Nawfal, Elie Bechara","doi":"10.1038/s41433-024-03465-8","DOIUrl":"https://doi.org/10.1038/s41433-024-03465-8","url":null,"abstract":"Background/objectives: To evaluate the long-term outcomes of patients enrolled in the retinoblastoma programme at the Children's Cancer Institute of the American University of Beirut Medical Center (AUBMC) and to assess the effects of the Lebanese economic crisis and the COVID-19 pandemic on treatment outcomes.Subjects/methods: A retrospective review of medical charts was conducted for retinoblastoma patients enrolled in the programme from 2012 to 2022. Parameters included age at diagnosis, gender, nationality, tumour characteristics, treatment modalities, follow-up duration, imaging results, and genetic testing outcomes. Outcomes were reported for the 10-year period and compared before and after 2019 (beginning of pandemic).Results: The cohort included 94 patients: 49(52%) with unilateral retinoblastoma (RB) and 45(48%) with bilateral tumours. Mean age at diagnosis was 19.96 ± 16.2 months (14.18 ± 13.33 months for the bilateral group and 25.27 ± 16.94 months for the unilateral group) with no difference between the 2 time periods. Eye preservation over the 10-year period was 58.4% for bilateral disease and 20.8% for unilateral disease. Ocular salvage rate tended to increase from 54.9% to 72.2% after 2019 in the bilateral group and from 14.3% to 38.5% in the unilateral group but without statistical significance. For the whole cohort, positive genetic testing for RB mutation increased from 25% to 46%. In those who underwent testing, detection of RB1 mutation was similar in patients before 2019 (58%) and after 2019 (62.5%).Conclusion: Our retinoblastoma programme demonstrated continued improved outcomes in terms of early detection, treatment, RB mutation detection, and eye preservation, despite the different challenges posed by the economic crisis and pandemic.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infographic: Randomised controlled trial of adjunctive triamcinolone acetonide in eyes undergoing vitreoretinal surgery following open globe trauma: THE ASCOT STUDY. 信息图：在开球创伤后接受玻璃体视网膜手术的眼睛中辅助使用曲安奈德的随机对照试验：ascot 研究。

IF 2.8 3区医学

Eye Pub Date : 2024-11-19 DOI: 10.1038/s41433-024-03483-6

Alhumam Alkhusheh, Muhammad Ashhad Noor

引用次数: 0

Artificial intelligence in assessing progression of age-related macular degeneration. 人工智能评估老年性黄斑变性的进展。

IF 2.8 3区医学

Eye Pub Date : 2024-11-18 DOI: 10.1038/s41433-024-03460-z

Sophie Frank-Publig, Klaudia Birner, Sophie Riedl, Gregor S Reiter, Ursula Schmidt-Erfurth

{"title":"Artificial intelligence in assessing progression of age-related macular degeneration.","authors":"Sophie Frank-Publig, Klaudia Birner, Sophie Riedl, Gregor S Reiter, Ursula Schmidt-Erfurth","doi":"10.1038/s41433-024-03460-z","DOIUrl":"10.1038/s41433-024-03460-z","url":null,"abstract":"The human population is steadily growing with increased life expectancy, impacting the prevalence of age-dependent diseases, including age-related macular degeneration (AMD). Health care systems are confronted with an increasing burden with rising patient numbers accompanied by ongoing developments of therapeutic approaches. Concurrent advances in imaging modalities provide eye care professionals with a large amount of data for each patient. Furthermore, with continuous progress in therapeutics, there is an unmet need for reliable structural and functional biomarkers in clinical trials and practice to optimize personalized patient care and evaluate individual responses to treatment. A fast and objective solution is Artificial intelligence (AI), which has revolutionized assessment of AMD in all disease stages. Reliable and validated AI-algorithms can aid to overcome the growing number of patients, visits and necessary treatments as well as maximize the benefits of multimodal imaging in clinical trials. Therefore, there are ongoing efforts to develop and validate automated algorithms to unlock more information from datasets allowing automated assessment of disease activity and disease progression. This review aims to present selected AI algorithms, their development, applications and challenges regarding assessment and prediction of AMD progression.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142667205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can we better understand strabismus research? 我们能否更好地了解斜视研究？

IF 2.8 3区医学

Eye Pub Date : 2024-11-18 DOI: 10.1038/s41433-024-03491-6

Suqing Gou, Jiexiao Chen, Jieling Chen

引用次数: 0

Association of macular microcirculation with renal function in Chinese non-diabetic patients with hypertension. 中国非糖尿病高血压患者黄斑微循环与肾功能的关系

IF 2.8 3区医学

Eye Pub Date : 2024-11-16 DOI: 10.1038/s41433-024-03482-7

Xiao-Hong Liu, Qi-Fang Huang, Yi-Lin Chen, Xin-Yu Wang, Yi-Sheng Zhong, Ji-Guang Wang

{"title":"Association of macular microcirculation with renal function in Chinese non-diabetic patients with hypertension.","authors":"Xiao-Hong Liu, Qi-Fang Huang, Yi-Lin Chen, Xin-Yu Wang, Yi-Sheng Zhong, Ji-Guang Wang","doi":"10.1038/s41433-024-03482-7","DOIUrl":"https://doi.org/10.1038/s41433-024-03482-7","url":null,"abstract":"Purpose: The aim of this study was to investigate the association of macular microcirculation with renal function and the feasibility of using macular microcirculatory parameters to monitor renal function in Chinese non-diabetic patients with hypertension.Methods: This case-control study included 62 non-diabetic patients with hypertension, including 31 with renal dysfunction (estimated glomerular filtration rate [eGFR] <90 mL/min/1.73 m2) and 31 with normal renal function (eGFR ≥90 mL/min/1.73 m2). Age, sex and clinic blood pressure were matched between groups. Macular microcirculatory parameters of 124 eyes of the 62 patients were evaluated by optical coherence tomography (OCT) and OCT angiography (OCTA).Results: In comparison with the patients with normal renal function, patients with renal dysfunction had lower macular superficial parafovea vessel density (18.6 vs. 19.4%, P = 0.029), macular cube average thickness (273.0 vs. 280.2 µm, P = 0.003), and average ganglion cell layer and inner plexiform layer (GCL-IPL) thickness (79.5 vs. 82.8 µm, P = 0.006), but similar macular central fovea vessel density and central fovea thickness (P ≥ 0.54). After adjustment for confounders, eGFR was significantly associated with macular superficial parafovea vessel density, cube average thickness and GCL-IPL thickness (P < 0.02). In detecting renal dysfunction, areas under the curve were 0.61, 0.66 and 0.65 for macular superficial parafovea vessel density, cube average thickness and GCL-IPL thickness.Conclusion: In non-diabetic patients with hypertension, macular superficial parafovea vessel density, cube average thickness and GCL-IPL thickness were significantly worse in patients with renal dysfunction than those with normal renal function. Using macular parameters to monitor renal function is feasible.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142644300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monovision versus multifocality for presbyopia during primary phacoemulsification: systematic review and network meta-analysis. 原发性超声乳化术中单焦与多焦治疗老花眼：系统综述和网络荟萃分析。

IF 2.8 3区医学

Eye Pub Date : 2024-11-15 DOI: 10.1038/s41433-024-03454-x

Ashley Shuen Ying Hong, Eric Jin, Liang Shen, David Z Chen

{"title":"Monovision versus multifocality for presbyopia during primary phacoemulsification: systematic review and network meta-analysis.","authors":"Ashley Shuen Ying Hong, Eric Jin, Liang Shen, David Z Chen","doi":"10.1038/s41433-024-03454-x","DOIUrl":"https://doi.org/10.1038/s41433-024-03454-x","url":null,"abstract":"This systematic review and network meta-analysis (NMA) focuses on comparing monovision and bilateral multifocal lenses (bMFIOL) implantation methods in treating presbyopia, a common age-related condition often seen in post-cataract surgery patients. This review focuses on evaluating the efficacy, user satisfaction and limitations of these two approaches through direct or indirect comparison. A comprehensive search was conducted in Medline, Embase, and Cochrane library, considering studies up to 15 July 2022, with direct or indirect comparisons between any monovision and bMFIOL implantation with bilateral cataract surgery. The study protocol has been published in the International Prospective Register of Systematic Reviews (PROSPERO, CRD42022340257). Thirty-two studies (3082 patients) were included in the NMA for the primary outcome, complete post-operative spectacle independence. NMA showed monovision to be inferior to bMFIOLs, as bMFIOL was more likely to provide complete spectacle independence (RR = 2.06, 95% CI = 1.34 to 3.15, p = 0.002) compared to monovision. Monovision resulted in less glare compared to bMFIOL (RR = 0.343, 95% CI = 0.181 to 0.651, p = 0.001). There was no statistically significant difference between monovision and bMFIOL for binocular unadjusted distance visual acuity (MD = 70.01, 95% CI = -19.88 to 4.60, p = 0.437) and binocular unadjusted near visual acuity (MD = 5.46, 95% CI = -5.24 to 10.94, p = 0.191). When compared to monovision, bMFIOL provided greater complete spectacle independence at the expense of greater glare. This study was limited by data heterogeneity, and further studies with standardized reporting would be useful.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refractive lens exchange - the evidence behind the practise. 屈光晶体交换--实践背后的证据。

IF 2.8 3区医学

Eye Pub Date : 2024-11-14 DOI: 10.1038/s41433-024-03478-3

Elsie Chan, Shivesh Varma

引用次数: 0

Associations of incident myopia and its development with related factors among school-aged children across different grades: a four-year longitudinal study. 不同年级学龄儿童近视发生及其发展与相关因素的关系：一项为期四年的纵向研究。

IF 2.8 3区医学

Eye Pub Date : 2024-11-14 DOI: 10.1038/s41433-024-03467-6

Lan Guo, Jiayu Zhang, Yangfeng Guo, Yin Hu, Lili Wang, Xiao Yang, Ciyong Lu

{"title":"Associations of incident myopia and its development with related factors among school-aged children across different grades: a four-year longitudinal study.","authors":"Lan Guo, Jiayu Zhang, Yangfeng Guo, Yin Hu, Lili Wang, Xiao Yang, Ciyong Lu","doi":"10.1038/s41433-024-03467-6","DOIUrl":"https://doi.org/10.1038/s41433-024-03467-6","url":null,"abstract":"Objective: To assess the progression of myopia across different academic grades and investigate the associations between potential myopia-related factors and the incidence of myopia at various grade levels.Methods: We utilized data from an ongoing longitudinal study that began with grade 1 students across 12 schools. Four waves of annual eye examinations and questionnaire surveys were conducted. Longitudinal analyses were performed on three groups: Group 1 (n = 1223, non-myopic in grade 1) examined factors in grade 1 associated with incident myopia in grade 2; Group 2 (n = 653, non-myopic in grade 2) investigated factors in grade 2 related to incident myopia in grade 3; and Group 3 (n = 746, non-myopic in grade 3) evaluated factors in grade 3 associated with incident myopia in grade 4.Results: The incidence of myopia increased from 4.3% in grade 2 to 21.6% in grade 4. Our findings revealed a consistent positive association between the number of myopic parents and incident myopia in grades 2, 3, and 4, respectively. Outdoor activity in earlier grades showed significant protective effects, reducing the risk of incident myopia in the subsequent grades 2 and 3 (e.g., in Group 1, adjusted HR 0.46 [95% CI 0.24 ~ 0.86]). However, no significant association was observed between outdoor activity in grade 3 and incident myopia in grade 4.Conclusions: It is important to consider the grade level of schoolchildren when addressing myopia control. Implementing early-phase interventions, particularly those emphasizing outdoor activities, may help mitigate the onset and progression of myopia during the earlier school years.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Artificial gravity as a potential countermeasure for Spaceflight Associated Neuro-Ocular Syndrome. 更正：人工重力作为太空飞行相关神经眼综合症的潜在对策。

IF 2.8 3区医学

Eye Pub Date : 2024-11-14 DOI: 10.1038/s41433-024-03458-7

Ethan Waisberg, Joshua Ong, Mouayad Masalkhi, Kazuhito Shimada, Andrew G Lee

引用次数: 0

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