Eye最新文献

{"title":"Predicting post-surgery change in visual acuity after successful repair of macula-off retinal detachments: findings from a large prospective UK cohort study.","authors":"David Yorston, Paul H J Donachie, D A Laidlaw, David H Steel, Tom H Williamson","doi":"10.1038/s41433-025-03752-y","DOIUrl":"https://doi.org/10.1038/s41433-025-03752-y","url":null,"abstract":"<p><strong>Objective: </strong>To identify risk factors affecting the change in visual acuity in successfully re-attached macula-off rhegmatogenous retinal detachment (RD) surgery.</p><p><strong>Design: </strong>A cohort study, using an online database, of visual outcomes for 2770 macula-off retinal detachments that were successfully re-attached by vitrectomy and internal tamponade. The database included detailed retinal diagrams of each detachment.</p><p><strong>Main outcome measure: </strong>The change in LogMAR visual acuity from pre-operatively to post-operatively.</p><p><strong>Results: </strong>Male patients accounted for 64.6% of the sample and the median age was 63 years old. The median pre-operative VA was counting fingers (LogMAR 1.98); this improved to 0.30 LogMAR post-operatively. An improvement in VA of ≥0.30 LogMAR was achieved by 88.0% eyes. The change in VA model identified the preoperative VA, patient age, duration of central vision loss, lens status at follow up, extent of detachment, and the number of breaks in the detached retina, as factors influencing the change in VA. The model had an adjusted R² of 0.749, and for 75.5% of eyes, the model prediction was within ±0.30 LogMAR of the recorded VA change.</p><p><strong>Conclusions: </strong>Greater post-operative visual acuity improvement was more likely in eyes that were pseudophakic at follow up, and had shorter durations of central vision loss. Non modifiable factors associated with greater vision improvement included worse presenting vision, younger age, less extensive detachment and less than three breaks in the detached retina. These results confirm that prompt surgery improves functional outcomes in successfully treated macula off retinal detachments irrespective of presenting visual acuity.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: 'The Royal College of Ophthalmologists' National Ophthalmology Database study of cataract surgery: report 19, a comparative study of the cost and carbon footprint of local anaesthesia techniques for cataract surgery'.","authors":"Goodness Daniel, Tom Eke","doi":"10.1038/s41433-025-03860-9","DOIUrl":"10.1038/s41433-025-03860-9","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy and safety of rituximab, tocilizumab, and teprotumumab in Graves' orbitopathy: a systematic review and meta-analysis.","authors":"Abdulelah G Abumohssin, Rayan A Alshareef, Saja Aljohani, Abdulrahman Alqutub, Abdulsalam Alqutub","doi":"10.1038/s41433-025-03845-8","DOIUrl":"https://doi.org/10.1038/s41433-025-03845-8","url":null,"abstract":"<p><p>Graves' orbitopathy (GO) affects 25-50% of patients with Graves' disease. It progresses through phases, from active inflammation to fibrosis. Thyrotropin-related antibodies (TRAb) and Insulin-like growth factor (IGF-1) contribute to GO's pathogenesis. Conventional treatments like glucocorticoids are often effective, but refractory cases require alternatives like rituximab (RTX), tocilizumab (TCZ), and teprotumumab (TPM). These monoclonal antibodies show promise but carry significant risks. This review aims to assess their efficacy and safety. We retrieved relevant articles up to July 2024 from five databases. Data were extracted from eligible studies by two independent reviewers, including clinical activity scores 7 and 10 (CAS), proptosis, antibody levels, and diplopia. All analyses were conducted using RevMan v5.4. In this review, we included 77 articles. Of these, 58 provided enough data for analysis. TPM, RTX, and TCZ all significantly reduced CAS-7 scores, with TCZ showing the most significant reduction (3.51 points, 95%CI: -4.25, -2.78), followed by TPM (3.1 points, 95%CI: -3.71, -2.49) and RTX. Similarly, for CAS-10, TCZ led with a 5.12-point reduction, significantly outperforming RTX (P = 0.0006). Proptosis decreased significantly with each drug, with TPM leading (2.95 mm), followed by TCZ (1.99 mm) and RTX (0.79 mm). TRAb Levels: TCZ reduced TRAb levels by 8.29 U/L (95%CI: -10.48, -6.09), significantly more than RTX (P = 0.03). Complications varied, with TPM linked to hyperglycemia and ototoxicity, TCZ to hematologic and metabolic issues, and RTX to infusion-related reactions. In conclusion, TCZ and TPM outperform RTX in treating GO, but TPM has higher complications, and RTX, though safer, shows more treatment failures.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical coherence tomography angiography as a tool for diagnosis and monitoring of sickle cell related eye disease: a systematic review and meta-analysis.","authors":"Kirsty Clarke, Ankith Mannath, Marco Anastasi, Mohamed Nasr, Shengning Pan, Konstantinos Balaskas, Christiana Dinah, Marinko V Sarunic, Riaz Asaria","doi":"10.1038/s41433-025-03814-1","DOIUrl":"https://doi.org/10.1038/s41433-025-03814-1","url":null,"abstract":"<p><p>Sickle cell retinopathy (SCR) is an ocular manifestation of sickle cell disease (SCD). In SCR abnormal sickling of erythrocytes is associated with sight-threatening complications such as neovascularisation, vitreous haemorrhage, maculopathy and retinal detachment. Optical coherence tomography angiography (OCTA) is a novel imaging modality enabling non-invasive assessment of retinal vasculature. This systematic review provides an up-to-date evaluation of the role of OCTA in SCR diagnosis and management. We searched MEDLINE/PubMed, Cumulated Index to Nursing and Allied Health Literature (CINAHL), SCOPUS and Cochrane Central Register of Controlled Trials (CENTRAL) electronic databases. The methodological quality of included studies was evaluated according to the STrengthening the Reporting of OBservational studies in Epidemiology (STROBE) recommendations. 31 studies met the inclusion criteria, and 26 suitably complied with the STROBE recommendations. Participant characteristics, including haemoglobin genotype, Goldberg staging, and visual acuity, were reported in twenty-eight (93%), twenty-six (86.6%), and fifteen (50%) studies, respectively. There was no consistent association between OCTA findings and haemoglobin genotype, Goldberg staging or visual acuity. Meta-analysis revealed that foveal avascular zone (FAZ) size and mean vessel density of the superficial and deep capillary plexi were significantly altered in patients with SCR compared to healthy controls. The mean vessel density of the superficial and deep capillary plexus was significantly lower in patients with SCR. OCTA can quantitatively detect retinal vascular remodelling in patients with SCR. Further research should focus on the clinical utility of OCTA for predicting SCR progression and its role in automating SCR staging using machine learning techniques.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of Terson syndrome: a photo essay.","authors":"Abhishek Gupta, Prabhakar Singh, Subodh Lakra","doi":"10.1038/s41433-025-03862-7","DOIUrl":"https://doi.org/10.1038/s41433-025-03862-7","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining the limits of upper and lower conjunctival fornix depths in a healthy Asian Chinese population.","authors":"See Teng Tan, Hla Myint Htoon, Matthew Davidson, Saaeha Rauz, Jodhbir S Mehta, Hon Shing Ong","doi":"10.1038/s41433-025-03828-9","DOIUrl":"https://doi.org/10.1038/s41433-025-03828-9","url":null,"abstract":"<p><strong>Background: </strong>The early detection of conjunctival fornix shortening is essential for the effective management of progressive cicatrising conjunctival diseases. Establishing a baseline reference for conjunctival scarring by determining the normative conjunctival fornix depths (FDs) allows for the measurement and monitoring of changes in the conjunctiva. This study explored anatomical variations in conjunctival FDs amongst an Asian Chinese population, providing valuable information for conjunctival fibrosis assessment.</p><p><strong>Methods: </strong>This retrospective study conducted at a single centre included 295 Chinese individuals (590 eyes) with normal conjunctiva who visited the eye clinic between 2019 and 2023. The lower and upper FDs were assessed using a validated FD measurer (FDM). Mean lower and upper FDs were calculated and stratified by age and gender.</p><p><strong>Results: </strong>The mean upper and lower conjunctival FDs for the Chinese population in Singapore were 16.1 mm ± 1.6 (95% CI, 15.9-16.2) and 10.1 mm ± 1.7 (95% CI, 10.0-10.3), respectively. Females exhibited shorter FDs (upper 15.7 mm ± 1.5; lower 9.8 mm ± 1.5) compared to males (upper 16.5 mm ± 1.5; lower 10.5 mm ± 1.9) (p < 0.001). Linear regression analysis demonstrated a significant inverse correlation between age and FDs, indicating that FDs decreases with advancing age (R² = 0.1469 for upper and 0.3195 for lower fornices; p < 0.001). Specifically, the mean upper FD ranged from 17.4 mm (95% CI, 17.2-17.7) in the 20-29 age group to 15.2 mm (95% CI, 14.9-15.5) in the 80-89 age group. Similarly, the mean lower FD ranged from 12.0 mm (95% CI, 11.6-12.4) in the 20-29 age group to 8.7 mm (95% CI, 8.5-9.0) in the 80-89 age group. Analysis of the 95% CIs revealed no statistical difference in FD measurements when compared to published Caucasians, South Asians, and Turkish populations.</p><p><strong>Conclusions: </strong>This study adds to the available literature a set of normative data for upper and lower FD in a Chinese population, highlighting gender-related variations and age-related progressive conjunctival shrinkage. The established dataset serves as a valuable resource for clinicians, enabling them to better manage and monitor patients with conjunctival diseases. These normative values in forniceal depths adds to available data obtained from Caucasian, South Asian, and Turkish eyes. Existing clinical assessment tools incorporating FD measurements, but validated in other ethnic populations, can be used in Chinese populations.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cochrane corner: lubricating drops for contact lens discomfort in adults.","authors":"Kaleb S Abbott, Darren G Gregory, Su-Hsun Liu","doi":"10.1038/s41433-025-03867-2","DOIUrl":"https://doi.org/10.1038/s41433-025-03867-2","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building consensus on MIGS: insights from a UKEGS survey.","authors":"Abdus Samad Ansari, Andrew J Tatham, Nishani Amerasinghe, Gus Gazzard","doi":"10.1038/s41433-025-03852-9","DOIUrl":"https://doi.org/10.1038/s41433-025-03852-9","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraocular lens models: Ecological distribution footprint and usage trends at a large ophthalmology centre.","authors":"Benjamin Stern, Damien Gatinel, Georges Nicolaos, Alice Grise-Dulac","doi":"10.1038/s41433-025-03848-5","DOIUrl":"https://doi.org/10.1038/s41433-025-03848-5","url":null,"abstract":"<p><strong>Background: </strong>Operating theatres significantly contribute to hospital's environmental footprint, underscoring the need to evaluate the ecological impact of transporting surgical products. Intraocular lenses (IOLs), sourced globally, vary in their environmental impact due to differences in packaging and manufacturing. Assessing the carbon footprint of IOL transport and usage can promote sustainability.</p><p><strong>Methods: </strong>A retrospective analysis of IOL stock data at Rothschild Foundation Hospital, Paris, was conducted to evaluate all IOLs implanted in 2023. To estimate the ecological footprint of IOL transport, the packaging weight of each model was measured, and the EcoTransIT online calculator was used.</p><p><strong>Results: </strong>In 2023, a total of 13,894 IOLs from 62 different models were implanted by 112 ophthalmic surgeons at our institution. Carbon dioxide (CO₂) emissions from the transport of IOL models varied from 1.05 to 12.72 kg per 1,000 units, influenced by packaging weight and shipping distances. Packaging volumes ranged from 135 to 917 cm³. Standard monofocal lenses comprised 65.9% of implanted IOLs, followed by monofocal \"plus\" lenses at 21.6%. Toric, non-toric extended depth of focus (EDOF), and non-toric multifocal lenses were used less frequently, at 7.4%, 3.9%, and 1.3%, respectively.</p><p><strong>Conclusions: </strong>Significant disparities exist in CO₂ emissions related to IOL distribution among different IOL models, highlighting the importance of minimising packaging to reduce environmental impact. Standard monofocal lenses remain the predominant choice among surgeons, with increasing adoption of monofocal \"plus\" lenses. Premium lenses are used sparingly. Optimising packaging could improve storage efficiency and logistics, potentially facilitating greater adoption of premium lenses, particularly toric lenses.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of treatment of primary congenital glaucoma on meibomian glands and tear film.","authors":"Ahmed S Elwehidy, Dina Abd Elfattah, Aya M Hashish, Muhammad Z Chauhan, Hajirah N Saeed, Abdelrahman M Elhusseiny","doi":"10.1038/s41433-025-03853-8","DOIUrl":"https://doi.org/10.1038/s41433-025-03853-8","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate meibomian gland (MG) and tear film alterations in treated primary congenital glaucoma (PCG) patients through a comparative study.</p><p><strong>Methods: </strong>We conducted a comparative, cross-sectional study analysing eyes with treated PCG vs healthy eyes of age-matched children using the MediWorks Dry Eye Diagnostic System to perform a non-contact quantitative analysis. Seven ocular parameters were measured: non-invasive break-up time (NIBUT), tear meniscus height, lipid layer thickness, eyelid edge morphology, MG morphology, ocular surface staining, and conjunctival hyperaemia.</p><p><strong>Results: </strong>Our study included 71 treated PCG eyes (42 patients) and 30 non-glaucomatous healthy eyes (30 patients). Thirty (21 patients) of the 71 treated PCG eyes (42.3%) were on topical glaucoma medications at the time of study enrolment. MG loss grade (1.3 ± 0.5 vs 0.1 ± 0.3, P < 0.001), mean first rupture NIBUT (7.2 ± 2.6 s vs 11.9 ± 2.4 s, P < 0.001), lipid layer grade (3.2 ± 0.6 vs 3.6 ± 0.5, P = 0.03), and prevalence of low tear meniscus height (46.5% vs 93.3%, P < 0.001) were all significantly altered in the treated PCG group as compared to healthy controls. Sub-group analyses revealed significantly worse MG and tear film parameters in treated PCG eyes on glaucoma medications vs treated PCG eyes not on glaucoma medications and treated PCG eyes not on glaucoma medications vs healthy controls. Glaucoma surgery was also associated with worse parameters.</p><p><strong>Conclusion: </strong>In this first study to evaluate MG and tear film parameters in treated PCG, significant differences were observed in the MG morphology and tear film parameters of eyes with treated PCG compared to the eyes of healthy children. Glaucoma medication use and glaucoma surgery were individually correlated with ocular surface disease in treated PCG.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}