Eye最新文献

{"title":"Defining a standards framework for ophthalmology real-world data methodologies through an expert-led Delphi consensus.","authors":"Pierre-Henry Gabrielle, Francesco Bandello, Aude Couturier, Christiana Dinah, Amanda Downey, Alessandro Invernizzi, Arshad M Khanani, Jorge C P Rocha, Insaf Saffar, Javier Zarranz-Ventura, Rishi P Singh","doi":"10.1038/s41433-026-04424-1","DOIUrl":"https://doi.org/10.1038/s41433-026-04424-1","url":null,"abstract":"<p><strong>Background/objectives: </strong>Real-world data (RWD) is becoming increasingly important in ophthalmology, offering insights into clinical outcomes, therapeutic approaches, and healthcare practices. However, methodological variability limits comparability and generalisability across RWD studies. This Delphi consensus aimed to establish expert agreement on the need for standardised methodologies in ophthalmology RWD studies, identify the key clinical and patient-reported data elements that should be collected, and explore strategies for consistent implementation.</p><p><strong>Methods: </strong>A modified Delphi methodology was followed. A steering committee (SC) of three ophthalmologists developed 38 consensus statements across five key topics. These statements were developed into an online four-point Likert scale survey and distributed to healthcare professionals experienced in managing retinal diseases via members of The Ophthalmology Network. Consensus was defined a priori as ≥75% agreement. Results were shared with the SC and key recommendations were discussed.</p><p><strong>Results: </strong>A total of 244 responses were received, predominantly from retina specialists (n = 232, 95%), with broad representation across six regions, the largest being Europe (n = 116, 48%). Consensus was achieved for all 38 statements, with 36 (95%) reaching ≥90%. These statements covered key principles, including: variability of current standards, ideal clinical standards for RWD collection, RWD analysis methodology, ideal patient-reported standards, and implementing and reporting consistent standards/frameworks. As the stopping criteria were met, no further Delphi rounds were conducted. Eight key recommendations were developed.</p><p><strong>Conclusions: </strong>The outputs from this consensus aim to guide future ophthalmology RWD studies towards improved consistency, reliability, and generalisability, ultimately strengthening the evidence base for clinical decision-making to improve patient outcomes.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147608500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Area Deprivation and Social Vulnerability Are Associated with Pediatric Vision Screening Outcomes in the University of California, Irvine EyeMobile Program.","authors":"Jainam Shah, John D Hong, Kimia Rezaei, Jordan Tang, Michael Madsen, Cecilia Vallejos, Kourosh Shahraki, Kimberly R Walker, Annabelle M Storch, Joseph H Bui, Jennifer Espinoza, Diana Torres, Donny W Suh","doi":"10.1038/s41433-026-04394-4","DOIUrl":"https://doi.org/10.1038/s41433-026-04394-4","url":null,"abstract":"<p><strong>Background: </strong>The Area Deprivation Index (ADI) and Social Vulnerability Index (SVI) are nationally validated neighborhood-level measures of socioeconomic disadvantage but remain understudied in pediatric ophthalmology. We examined associations between ADI/SVI and school-based vision screening outcomes, refractive error (RE), best-corrected visual acuity (BCVA), and amblyopia suspect status.</p><p><strong>Methods: </strong>We conducted a retrospective study of children aged 3-10 years screened by the UCI EyeMobile program (Orange County, California, United States) from 2021-2024. Among 15,842 children screened, 3,350 underwent comprehensive examination. School addresses were geocoded to ADI/SVI quartiles (Q1-Q4; higher quartiles indicate greater disadvantage). Outcomes included referral, 'fit-for-frames,' RE, amblyopia suspect status, and poor BCVA (>0.2 logMAR). Group differences were assessed using chi-square and Cochran-Armitage trend tests. Multivariable regression evaluated associations with ADI/SVI after adjustment for age, sex, race/ethnicity, and RE type and severity. Race × index interactions were evaluated, and stratified analyses were performed when significant.</p><p><strong>Results: </strong>Children in Q4 neighborhoods had higher referral rates and were more likely to require new spectacles despite passing screening. Myopia was less common, whereas astigmatism was more common in Q4. After adjustment, both poor BCVA and amblyopia suspect status increased across quartiles (p-trend < 0.001). Compared with Q1, Q4 was associated with higher odds of poor BCVA (aOR [95% CI]: 1.51 [1.13-2.01] for ADI; 1.61 [1.18-2.20] for SVI) and amblyopia suspect status (1.78 [1.30-2.43]; 1.82 [1.33-2.48]). Significant interactions were observed, with stronger Q4 versus Q1 effects among Hispanic (aOR: 1.87) and Asian (aOR: 1.62) children, but not among Caucasian children.</p><p><strong>Conclusions: </strong>Children from the most disadvantaged neighborhoods had higher odds of amblyopia suspect status and poor BCVA. These findings support incorporating ADI/SVI in pediatric vision care to identify underserved children proactively, allocate resources equitably, and reduce the risk of permanent visual impairment.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147591131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A real-world, population-based disproportionality analysis of glaucoma and cataracts attributed to steroids.","authors":"Andrew Mihalache, Ryan S Huang, Michael Balas, David J Mathew","doi":"10.1038/s41433-026-04440-1","DOIUrl":"https://doi.org/10.1038/s41433-026-04440-1","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147591099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global, regional, national differences and gender disparity in the burden of cataract: current trends and future projections.","authors":"Bianjin Sun, Qiheng Yuan, Siwen Chen, Gengzhong Chen, Yutong Kang, Meiqin Zheng","doi":"10.1038/s41433-026-04393-5","DOIUrl":"https://doi.org/10.1038/s41433-026-04393-5","url":null,"abstract":"<p><strong>Background: </strong>This research investigates cataract incidence patterns in individuals aged 60 and older, projects future trends, and offers insights to inform targeted preventive actions.</p><p><strong>Methods: </strong>Data on cataract incidence were sourced from the 2021 Global Burden of Disease dataset. The study assessed links with the Socio-Demographic Index (SDI), examined disparities, and employed frontier and decomposition analyses to uncover mechanisms of burden evolution. Trends across age groups, time periods, and birth cohorts were explored using an Age-Period-Cohort (APC) framework, while the Bayesian Age-Period-Cohort (BAPC) model enabled future burden projections.</p><p><strong>Results: </strong>From 1990 to 2021, cataract cases surged globally, rising from 32.8 million to over 82 million. Despite this, the age-adjusted rate declined overall, except in low- and middle-SDI settings, where increases persisted. Disparities remain pronounced in less-developed regions, though the absolute inequality gap has lessened. Population expansion emerged as the primary contributor to incidence growth. Projections suggest low-income regions will bear a disproportionate burden, while high-SDI areas benefit from early screening and improved care. By 2030, cataract cases may reach 111 million, with stable age-standardised rates.</p><p><strong>Conclusions: </strong>The global cataract burden is escalating, primarily driven by demographic shifts. Resource-limited countries, particularly China and India, will confront rising challenges. Region-specific strategies, especially enhancing access to eye care and surgery in underserved areas, are essential to curbing the future impact.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147591110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vector analysis of a toric refractive multifocal IOL with continuous transitional focus technology: rotational and refractive outcomes, a pilot evaluation.","authors":"Ronald Steven S Medalle, Antonio Martínez-Abad, Jorge L Alió","doi":"10.1038/s41433-026-04435-y","DOIUrl":"https://doi.org/10.1038/s41433-026-04435-y","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147590804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Massive macular lipid exudation in chronic ischemic central retinal vein occlusion.","authors":"Samarth Kacker, Vignesh T P","doi":"10.1038/s41433-026-04431-2","DOIUrl":"https://doi.org/10.1038/s41433-026-04431-2","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infographic: teprotumumab for the treatment of active thyroid eye disease.","authors":"Erind Alushaj, Michael Lowe, Susan P Mollan, Sarah M Simpson, Gabriele Berman","doi":"10.1038/s41433-026-04432-1","DOIUrl":"https://doi.org/10.1038/s41433-026-04432-1","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147581042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long term evolutions of hard exudates after anti-VEGF therapy for diabetic macular oedema.","authors":"Kangyeun Pak, Changki Yoon, Srinivas R Sadda","doi":"10.1038/s41433-026-04408-1","DOIUrl":"https://doi.org/10.1038/s41433-026-04408-1","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate longitudinal change in hard exudate (HEs) volume over 5-years following anti-VEGF treatment for diabetic macular oedema (DMO).</p><p><strong>Methods: </strong>This study was a post-hoc analysis of structural optical coherence tomography (OCT) volume scans collected in the Diabetic Retinopathy Clinical Research Network Protocol T extension trial. A deep learning model was used to segment HEs and compute a HEs volume (mm³) for the entire OCT scan at baseline, 12, 24, 52, 104, 260 weeks (w). HEs volume was also quantified within the central subfield (CSF), inner ring (IR), and outer ring (OR) of ETDRS grid. Change in HEs over time was compared among treatment arms and a multiple regression analysis was used to evaluate the impact of HEs on visual outcomes relative to other biomarkers.</p><p><strong>Results: </strong>116 eyes were included (aflibercept: 44, bevacizumab: 30, ranibizumab: 42) in the final analysis. Across all studied regions, HEs significantly decreased through w52 (p < 0.001), and from w52 to w104, a further significant decrease was observed in the total macula and IR, though no additional reduction between w104 and w260. Change in VA at w260 was associated with baseline VA and w260 change in CST, but not with baseline HEs. At w52, HEs reduction was significantly greater with aflibercept and ranibizumab compared to bevacizumab, but no longer significant at w104 and w260.</p><p><strong>Conclusions: </strong>Following anti-VEGF therapy, HEs decreased through w104, but stabilised after that, and initial differences among agents disappeared by two years. The change in HEs did not predict w260 visual outcomes.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147573024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extreme multifocal orbital cavernous haemangioma: over 44 tumours in one orbit.","authors":"Xinyue Ma, Huijing Ye, Huasheng Yang","doi":"10.1038/s41433-026-04418-z","DOIUrl":"https://doi.org/10.1038/s41433-026-04418-z","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147527958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the use of the Optos Silverstone widefield imaging system with ultrasound B-scanning for the assessment of choroidal naevi.","authors":"Laura N Cushley, Ryan Murdock, Tunde Peto, Anjanette McCaw, Richard Best, Giuliana Silvestri","doi":"10.1038/s41433-026-04437-w","DOIUrl":"https://doi.org/10.1038/s41433-026-04437-w","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147527890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}