{"title":"Forest of darkness: imaging with OCT-angiography as a useful tool to study corneal vascularization.","authors":"Ritu Arora, Rushad Shroff, Palak Gupta, Jatin Arora","doi":"10.1038/s41433-025-03593-9","DOIUrl":"https://doi.org/10.1038/s41433-025-03593-9","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EyePub Date : 2025-01-11DOI: 10.1038/s41433-024-03582-4
Kejie Du, Wenjuan Luo
{"title":"Efficacy and safety of robotic Cyberknife radiotherapy in uveal melanoma: a systematic review and meta-analysis","authors":"Kejie Du, Wenjuan Luo","doi":"10.1038/s41433-024-03582-4","DOIUrl":"10.1038/s41433-024-03582-4","url":null,"abstract":"This systematic review is aimed to evaluate the efficacy and safety of robotic Cyberknife radiotherapy (CKRT) in the treatment of uveal melanoma (UM). Clinical studies published in English that assessed the efficacy and safety of robotic CKRT in UM were systematically searched in PubMed, Web of Science, Cochrane and Embase from inception to July 2023. Studies reporting extraocular tumours or other radiosurgery approaches were excluded. Outcomes measured were tumour size, reflectivity, local tumour control rate, eye retention rate, survival rate, complication rate, recurrence rate, and metastasis rate. Ten eligible articles involving 2370 patients with 2372 UMs were included in evidence synthesis. Meta-analysis showed 811 of 912 patients (0.89, 95% Cl: 0.86, 0.92) maintained local control for three years, and 1448 of 1724 patients (0.84, 95% Cl: 0.81, 0.88) preserved the eye in three years. During follow-up, 91% (0.91, 95% Cl: 0.85, 0.97) patients survived and 351 of 1720 patients (0.23, 95% Cl: 0.09, 0.37) involving 1722 eyes had tumour recurrence. In addition, 1376 patients (0.79, 95% Cl: 0.77, 0.82) preserved the eyeball in five years. Following treatment, approximately 20% of patients had radiation retinopathy (95% Cl: 0.13, 0.28), 19% developed glaucoma (95% Cl: 0.11, 0.28), and 22% experienced retinal detachment (95% Cl: 0.07, 0.36). CKRT is a viable, noninvasive RT for UM. The rate of local tumour control following treatment is comparable to that of other RT approaches, providing additional options based on the patient’s condition.","PeriodicalId":12125,"journal":{"name":"Eye","volume":"39 3","pages":"548-555"},"PeriodicalIF":2.8,"publicationDate":"2025-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EyePub Date : 2025-01-10DOI: 10.1038/s41433-024-03587-z
Pasquale Viggiano, Sibel Demirel, Giovanni Petruzzella, Mariagrazia Pignataro, Giacomo Boscia, Arcangelo Clemente, Enrico Borrelli, Michele Reibaldi, Giovanni Alessio, Jay Chhablani, Francesco Boscia
{"title":"Choriocapillaris flow in two different patterns of exudative type 1 macular neovascularization","authors":"Pasquale Viggiano, Sibel Demirel, Giovanni Petruzzella, Mariagrazia Pignataro, Giacomo Boscia, Arcangelo Clemente, Enrico Borrelli, Michele Reibaldi, Giovanni Alessio, Jay Chhablani, Francesco Boscia","doi":"10.1038/s41433-024-03587-z","DOIUrl":"10.1038/s41433-024-03587-z","url":null,"abstract":"To compare the characteristics of type 1 macular neovascularization (MNV) and the surrounding choriocapillaris (CC) perfusion in patients with neovascular age-related macular degeneration (nAMD) versus those with pachychoroid neovasculopathy (PNV) using swept-source optical coherence tomography angiography (SS-OCTA). This retrospective study included 64 treatment-naïve eyes (37 nAMD, 27 PNV) with type 1 MNV. SS-OCTA images were analysed to measure MNV area and perimeter, and CC flow deficits (FD) in five concentric rings surrounding the lesion. CC FD percentage (FD%), area (FDa), and number (FDn) were quantified. Intervortex anastomoses presence was also assessed. MNV lesions in nAMD were significantly larger in area (2.94 vs 1.56 mm², p = 0.013) and perimeter (8.76 vs 5.85 mm, p = 0.004) compared to PNV. PNV eyes showed higher FD% and larger FDa across all rings (p < 0.05), while FDn did not differ significantly. Intervortex anastomoses were more prevalent in PNV (81.5% vs 35.1%, p = 0.0002). In nAMD, MNV size correlated positively with FD% in inner rings and FDn in all rings. In PNV, MNV size correlated only with FDn. Despite smaller MNV lesions, PNV eyes demonstrated more extensive CC flow deficits compared to nAMD. The distinct CC flow patterns and their correlations with MNV characteristics suggest different pathophysiological mechanisms underlying these conditions. These findings may have implications for differential diagnosis and tailored treatment approaches in nAMD and PNV.","PeriodicalId":12125,"journal":{"name":"Eye","volume":"39 3","pages":"556-562"},"PeriodicalIF":2.8,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EyePub Date : 2025-01-10DOI: 10.1038/s41433-024-03591-3
Athar Zareei, Reza Razeghinejad, Mohammad Reza Talebnejad, Mohammad Reza Khalili, Masoumeh Sadat Masoumpour, Zahra Shayan, Hamideh Mahdaviazad, Maryam Keshtkar, Elham Mohammadi, Zahra Tajbakhsh, M. Hossein Nowroozzadeh
{"title":"Establishing normal interocular symmetry range for macular optical coherence tomography parameters in healthy children","authors":"Athar Zareei, Reza Razeghinejad, Mohammad Reza Talebnejad, Mohammad Reza Khalili, Masoumeh Sadat Masoumpour, Zahra Shayan, Hamideh Mahdaviazad, Maryam Keshtkar, Elham Mohammadi, Zahra Tajbakhsh, M. Hossein Nowroozzadeh","doi":"10.1038/s41433-024-03591-3","DOIUrl":"10.1038/s41433-024-03591-3","url":null,"abstract":"The study aimed to evaluate the interocular symmetry of macular sublayer thickness among healthy children aged 6-12 years. The Shiraz Pediatric Eye Study included 500 randomly selected children who underwent SD-OCT of the macula and optical biometry using the IOLMaster-500. Exclusion criteria involved ocular abnormalities or axial lengths outside the 21.5–26.5 mm range. Software recorded total retinal thickness and sublayer thickness within each ETDRS subfield. The study included 862 eyes from 431 healthy children, with 254 girls (59%). The anticipated variation in total retinal thickness between eyes was below 13 µm in the fovea and under 7 µm in the inner or outer ring for 95% of the population. For nerve fiber layer and inner plexiform layer, the expected variation ranged from 2 to 4 µm, and for the ganglion-cell layer, it ranged from 2.5 to 5 µm. Intraclass correlation coefficient (ICC) rankings for retinal topography were highest in the outer ring, followed by the inner ring and fovea. The highest ICC for individual layers was found in overall retinal thickness, followed by inner retinal layers, outer-nuclear layer, inner plexiform layer, and inner nuclear layer. The study establishes a reliable reference range for interocular variances in macular sublayers, aiding clinical decision-making. The outer ring (3–6 mm) is most dependable for analysing most sublayers, while the inner ring is most suitable for examining the ganglion-cell layer.","PeriodicalId":12125,"journal":{"name":"Eye","volume":"39 3","pages":"563-569"},"PeriodicalIF":2.8,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142964335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EyePub Date : 2025-01-09DOI: 10.1038/s41433-024-03585-1
Giovanni Neri, Sohum Sharma, Beatrice Ghezzo, Cristina Novarese, Chiara Olivieri, Davide Tibaldi, Paola Marolo, Daniel B. Russakoff, Jonathan D. Oakley, Michele Reibaldi, Enrico Borrelli
{"title":"Deep learning model for automatic detection of different types of microaneurysms in diabetic retinopathy","authors":"Giovanni Neri, Sohum Sharma, Beatrice Ghezzo, Cristina Novarese, Chiara Olivieri, Davide Tibaldi, Paola Marolo, Daniel B. Russakoff, Jonathan D. Oakley, Michele Reibaldi, Enrico Borrelli","doi":"10.1038/s41433-024-03585-1","DOIUrl":"10.1038/s41433-024-03585-1","url":null,"abstract":"This study aims to develop a deep-learning-based software capable of detecting and differentiating microaneurysms (MAs) as hyporeflective or hyperreflective on structural optical coherence tomography (OCT) images in patients with non-proliferative diabetic retinopathy (NPDR). A retrospective cohort of 249 patients (498 eyes) diagnosed with NPDR was analysed. Structural OCT scans were obtained using the Heidelberg Spectralis HRA + OCT device. Manual segmentation of MAs was performed by five masked readers, with an expert grader ensuring consistent labeling. Two deep learning models, YOLO (You Only Look Once) and DETR (DEtection TRansformer), were trained using the annotated OCT images. Detection and classification performance were evaluated using the area under the receiver operating characteristic (ROC) curves. The YOLO model performed poorly with an AUC of 0.35 for overall MA detection, with AUCs of 0.33 and 0.24 for hyperreflective and hyporeflective MAs, respectively. The DETR model had an AUC of 0.86 for overall MA detection, but AUCs of 0.71 and 0.84 for hyperreflective and hyporeflective MAs, respectively. Post-hoc review revealed that discrepancies between automated and manual grading were often due to the automated method’s selection of normal retinal vessels. The choice of deep learning model is critical to achieving accuracy in detecting and classifying MAs in structural OCT images. An automated approach may assist clinicians in the early detection and monitoring of diabetic retinopathy, potentially improving patient outcomes.","PeriodicalId":12125,"journal":{"name":"Eye","volume":"39 3","pages":"570-577"},"PeriodicalIF":2.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142947122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EyePub Date : 2025-01-07DOI: 10.1038/s41433-024-03570-8
Selim Doganay, Gamze Ucan Gunduz, Mehmet Omer Kiristioglu, Elif Demirel, Ozgur Yalcinbayir
{"title":"Safety and efficacy of supraciliary dexamethasone implantation for macular oedema: a preliminary comparative study","authors":"Selim Doganay, Gamze Ucan Gunduz, Mehmet Omer Kiristioglu, Elif Demirel, Ozgur Yalcinbayir","doi":"10.1038/s41433-024-03570-8","DOIUrl":"10.1038/s41433-024-03570-8","url":null,"abstract":"To evaluate the efficacy and safety of dexamethasone implantation in the supraciliary (SC) space, a novel and potential effective implantation site, compared to intravitreal (IV) application. This prospective study included 39 eyes of 38 patients with macular oedema (ME) who underwent SC and IV dexamethasone implantation (SC-DEX and IV-DEX). Patients were randomly assigned to treatment groups and followed for 3 months. Preoperative and postoperative assessments included maximum retinal thickness (MRT), change in central retinal thickness between consecutive visits (ΔCRT), intraocular pressure (IOP), and best corrected visual acuity (BCVA). Both SC-DEX and IV-DEX groups showed significant MRT reductions during at follow-up. In the SC group, MRT significantly decreased at 1st and 3rd months (p = 0.0002 for both), but not at 1st week (p = 0.2517). In the IV-DEX group, significant reductions in MRT were observed at all postoperative visits: 1st week (p = 0.0002), 1st month (p = 0.0004), and 3rd month (p = 0.0003). There were no significant differences in the change in ΔCRT between the SC-DEX and IV-DEX groups at any visit (p > 0.05). IOP did not show significant changes (p > 0.05). BCVA improved significantly in the SC group compared to the IV-DEX group during the first week (p = 0.014). No other perioperative or postoperative sight-threatening complications were noted in either group, including hypotony or endophthalmitis. SC-DEX shows promise as an alternative for managing ME, offering similar effectiveness to IV-DEX with safe profile. Further studies are needed to confirm its long-term safety and efficacy.","PeriodicalId":12125,"journal":{"name":"Eye","volume":"39 3","pages":"586-592"},"PeriodicalIF":2.8,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41433-024-03570-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142947129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EyePub Date : 2025-01-07DOI: 10.1038/s41433-024-03578-0
Gustavo D. Aguirre, William A. Beltran
{"title":"Canine Best disease as a translational model","authors":"Gustavo D. Aguirre, William A. Beltran","doi":"10.1038/s41433-024-03578-0","DOIUrl":"10.1038/s41433-024-03578-0","url":null,"abstract":"In this review, we summarize the findings of several pre-clinical studies in the canine BEST1 disease model. To this end, client-owned and purpose bred dogs that were compound heterozygotes or homozygotes, respectively, for two or one of 3 different mutations in BEST1 were evaluated by ophthalmic examination, cSLO/sdOCT imaging, and retinal immunohistochemistry to characterize the clinical and microanatomic features of the disease. Subsequently AAV-mediated gene therapy was done to transfer the BEST1 transgene to the RPE under control of a hVMD2 promoter. We demonstrated that canine bestrophinopathies are an RPE-photoreceptor interface disease with underdeveloped RPE apical microvilli that invest rod and cone outer segments. This leads to microdetachments which later progress to clinically evident RPE-retinal separation and a spectrum of disease stages, ranging from vitelliform to vitelliruptive/atrophic lesions, similar to Best Vitelliform Macular Dystrophy (BVMD). Gene therapy corrects the microdetachments and reverses large lesions when delivered at the pseudohypopyon stage of disease. Because of the similar clinical and microstructural abnormalities between the canine model and BVMD, and positive response to gene therapy, the canine model is a valuable translational model for developing gene and other therapies for BVMD.","PeriodicalId":12125,"journal":{"name":"Eye","volume":"39 3","pages":"412-417"},"PeriodicalIF":2.8,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41433-024-03578-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142947121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EyePub Date : 2025-01-07DOI: 10.1038/s41433-024-03526-y
Magda A. Torky, Amgad El Nokrashy, Heba Metwally, Ameera G. Abdelhameed
{"title":"Editorial Expression of Concern: Visual performance following implantation of presbyopia correcting intraocular lenses","authors":"Magda A. Torky, Amgad El Nokrashy, Heba Metwally, Ameera G. Abdelhameed","doi":"10.1038/s41433-024-03526-y","DOIUrl":"10.1038/s41433-024-03526-y","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":"39 1","pages":"201-201"},"PeriodicalIF":2.8,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41433-024-03526-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142947125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}