Eye最新文献

{"title":"A population-based study on association of iridocyclitis with Sjogren's syndrome.","authors":"Hsin-Yu Lu, Jau-Der Ho, Hsin-Chien Lee, Shih-Han Hung, Tsai-Ching Liu, Herng-Ching Lin","doi":"10.1038/s41433-025-03798-y","DOIUrl":"10.1038/s41433-025-03798-y","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1643-1645"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The varieties of junctional scotoma: 17 cases, a review, and a taxonomy.","authors":"Jason J S Barton, Gülcenur Özturan","doi":"10.1038/s41433-025-03789-z","DOIUrl":"10.1038/s41433-025-03789-z","url":null,"abstract":"<p><p>The hemi-decussation at the optic chiasm creates the potential for crossed and uncrossed fibers to be affected in isolation or in various combinations of nerve, chiasm and tract, with patterns that reflect the retinotopic arrangement of axons. We present seventeen cases that illustrate the field defects that can result and review the literature to create a taxonomy of junctional visual field defects. The complete junction defect is blindness in one eye and loss of the entire temporal field of the other. The classic junctional scotoma combines optic neuropathy in one eye with upper temporal hemifield loss in the other, and is often a sign of ventral compression. The less frequent atypical junctional scotoma involves the lower temporal hemifield and has a higher frequency of dorsal compression or non-compressive pathology. There are the monocular defects in the temporal ('junctional scotoma of Traquair') or nasal hemifield, the latter of which is rarely if ever due to a pituitary adenoma. Highly asymmetric bitemporal defects with or without a central scotoma and the paradoxical junctional scotoma occur by extension of the lesion causing the junctional scotoma of Traquair. The posterior junction defect results from combined damage to the optic chiasm and optic tract. Recognizing these various patterns is important clinically as junctional defects have the same localizing significance as bitemporal defects and are being encountered more often. In addition the probability of certain types of pathology varies with the type of junctional defect.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1673-1687"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burdens and trends of age-related macular degeneration at global, regional, and national levels,1990-2021: findings from the 2021 global burden of disease study.","authors":"Yanping Zhou, Wenchang Jia, Jianling Song, Min Li, Wei Dai, Jian Zou, Jing Zhou, Xiangwu Chen, Xiaopan Li","doi":"10.1038/s41433-025-03686-5","DOIUrl":"10.1038/s41433-025-03686-5","url":null,"abstract":"<p><strong>Objectives: </strong>To assess global, regional, and national burdens and trends of age-related macular degeneration (AMD) from 1990 to 2021.</p><p><strong>Methods: </strong>Data from the Global Burden of disease Study 2021(GBD 2021) were used. The primary measurement were prevalent cases, years lived with disability (YLDs), age-standardised prevalence rate (ASPR) and age-standardised YLDs rate (ASYR), categorized by age and sociodemographic index (SDI). Trend analysis was measured by calculating average annual percentage change (AAPC) of ASPR and ASYR.</p><p><strong>Results: </strong>Globally, the prevalent AMD cases increased to 8,057,520.459 (95% uncertainty interval [UI], 6,705,283.83 to 9,823,237.34) in 2021, with associated YLDs rising to 577,984.5004 (95% UI, 401,188.20 to 797,657.63). AMD burdens varied across regions and countries, as well as level of SDI development. China, India, and the United States of America (USA) were the top three countries with AMD cases. Caribbean regions have significant lower ASPR and ASYR of AMD. The AMD burden peaked between ages 65-69. Females had a significantly higher burden of AMD compared to males. From 1990 to 2021, the global ASPR and ASYR showed downward trend (AAPC = -0.15, 95% confidence interval [CI], -0.19 to -0.12, P < 0.001; AAPC = -0.69, 95% CI, -0.71 to -0.67, P < 0.001) respectively. The USA is the only developed country showed decreasing AAPCs of ASPR and ASYR from 1990 to 2021 but increasing AAPCs of ASPR and ASYR from 2012 to 2021.</p><p><strong>Conclusions: </strong>AMD burdens increased over 30 years, varying by age, sex, and SDI, guiding global strategies and public health interventions.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1517-1525"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089386/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LLM-assisted medical documentation: efficacy, errors, and ethical considerations in ophthalmology.","authors":"Shrirajh Satheakeerthy, Daniel Jesudason, James Pietris, Stephen Bacchi, Weng Onn Chan","doi":"10.1038/s41433-025-03767-5","DOIUrl":"10.1038/s41433-025-03767-5","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1440-1442"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089378/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum of presentation of intraocular metastases from cutaneous melanoma in the era of immunotherapy and targeted therapies.","authors":"Stéphanie Lemaître, Amit K Arora, Gordon Robert Hay, Mandeep S Sagoo","doi":"10.1038/s41433-025-03753-x","DOIUrl":"10.1038/s41433-025-03753-x","url":null,"abstract":"<p><strong>Background: </strong>Intraocular metastases from cutaneous melanoma are rare. Diagnosis can be challenging and there is currently no consensus on treatment. However, with the increasing incidence of this cancer and improved survival of patients treated with targeted BRAF-MEK inhibitors and checkpoint inhibitors, it is likely that more cases will be referred to ocular oncology clinics.</p><p><strong>Subjects: </strong>Single-centre retrospective study. We included all the patients diagnosed with intraocular metastases from cutaneous melanoma seen between 2017 and 2022.</p><p><strong>Results: </strong>The first patient had bilateral choroidal metastases and unilateral vitreous cells (treated with external beam radiotherapy and immunotherapy), the second had unilateral amelanotic vitreous metastasis (treated with vitrectomy and BRAF-MEK inhibitors) and the third had bilateral multifocal choroidal metastases (treated with BRAK-MEK inhibitors followed by immunotherapy). The fourth patient (previously reported) had unilateral anterior segment and vitreous metastases (treated with immunotherapy and enucleation). Interestingly, two patients had a history of uveitis in the affected eye, unrelated to the ocular metastases. All four patients had synchronous systemic metastases.</p><p><strong>Conclusions: </strong>The diagnosis of intraocular metastases from cutaneous melanoma is generally clinical but it is sometimes challenging because of possible masquerade syndromes. The presence of other extraocular metastatic sites is an indicator of the diagnosis. Cytopathologic proof combined with genetic analysis is sometimes necessary for diagnosis, especially with amelanotic vitreous debris or in rare cases where systemic screening is negative. New treatments with targeted BRAF-MEK inhibitors and checkpoint inhibition may avoid external beam radiotherapy and enucleation in some patients.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1825-1830"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term macular atrophy growth in neovascular age-related macular degeneration: influential factors and role of genetic variants.","authors":"Brice Nguedia Vofo, Yahel Shwartz, Yaacov Cnaany, Shlomit Jaskoll, Adi Kramer, Sarah Elbaz-Hayoun, Batya Rinsky, Michelle Grunin, Liran Tiosano, Itay Chowers","doi":"10.1038/s41433-025-03723-3","DOIUrl":"10.1038/s41433-025-03723-3","url":null,"abstract":"<p><strong>Objectives: </strong>This retrospective cohort study aimed to assess the long-term growth and associated risk factors of macular atrophy (MA) in eyes with neovascular age-related macular degeneration (nAMD) treated with intravitreal anti-vascular endothelial growth factor (anti-VEGF) compounds.</p><p><strong>Methods: </strong>Two hundred and six patients initiating anti-VEGF therapy were followed for 8 years using a treat-and-extend protocol. The study analysed correlations between MA growth (by square root transformation measured in infrared images) and clinical parameters, and genetic variants for AMD in the complement and lipid pathways and the ARMS2 gene.</p><p><strong>Results: </strong>Seventy-six patients (n = 92 eyes) were included, with a mean age of 73.9 ± 7.9 years. Eyes received an average of 7.1 ± 3.2 anti-VEGF injections per year. The prevalence of MA increased from 28.3% at baseline to 78.3% at 8 years, exhibiting an average annual growth rate of 0.25 ± 0.22 mm. Correlations were found between MA growth and size, and number of atrophic foci at baseline, and the common ARMS2 variant. Eyes with subretinal fluid (SRF) at baseline showed less foveal atrophy at 8 years compared to those with IRF or both IRF and SRF. No correlation was observed between MA growth and genetic variants in the complement and lipid pathways.</p><p><strong>Conclusion: </strong>Most eyes with nAMD under 8 years of anti-VEGF therapy developed MA, with significant growth. Correlations with baseline MA characteristics and the ARMS2 variant were identified. Further investigation is needed to understand the potential role of complement as a therapeutic target for preventing macular atrophy in nAMD-affected eyes.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1717-1723"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence improves follow-up appointment uptake for diabetic retinal assessment: a systematic review and meta-analysis.","authors":"Masoud Rahmati, Lee Smith, Mapa Prabhath Piyasena, Michael Bowen, Laurent Boyer, Guillaume Fond, Abdolreza Kazemi, Dong Keon Yon, Hayeon Lee, Tarnjit Sehmbi, Sanjiv Ahluwalia, Shahina Pardhan","doi":"10.1038/s41433-025-03849-4","DOIUrl":"https://doi.org/10.1038/s41433-025-03849-4","url":null,"abstract":"<p><strong>Background/objectives: </strong>Artificial intelligence (AI) assessment of diabetic retinopathy (DR) instead of scarce trained specialists could potentially increases the efficiency and accessibility of screening programs. This systematic review aims to systematically examine the uptake of follow-up appointments with initial computer-based AI and human graders of DR.</p><p><strong>Methods: </strong>We conducted a systematic review and meta-analysis by screening articles in any languages in PubMed, MEDLINE (Ovid), EMBASE, Web of Science, Cochrane CENTRAL and CDSR published from database inception up to 20^th August 2024. We used random-effects meta-analysis to pool the results as odds ratios (OR) with corresponding 95% confidence intervals (CI).</p><p><strong>Results: </strong>Data from a total of 20,108 patients with diabetes (6476 participants graded using AI and 13,632 participants graded by human-graders; age range of the participants 5 to 67 years) from six studies were included. The result of the pooled meta-analysis showed that initial AI assessment of DR significantly increased uptake of follow-up appointments compared to human grader-based (OR = 1.89, 95% CI 1.78-2.01, P = 0.00001).</p><p><strong>Conclusions: </strong>The present systematic review and meta-analysis suggest that initial AI-based algorithm for screening DR is associated with an increased uptake of follow-up examination. This is most likely due to instant results being made available with AI based algorithms when compared to a delay in assessment with human graders.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Polygenic Risk Scores on Retinal Microstructures in Early and Intermediate Age-related Macular Degeneration: the Northern Ireland Sensory Aging Study.","authors":"Fangyao Tang, Ruth E Hogg, Bethany E Higgins, David M Wright, Laura Smyth, Sobha Sivaprasad","doi":"10.1038/s41433-025-03844-9","DOIUrl":"https://doi.org/10.1038/s41433-025-03844-9","url":null,"abstract":"<p><strong>Background: </strong>Although polygenic risk scores (PRSs) have been developed for age-related macular degeneration (AMD), it is not known whether these scores are associated with changes of retinal microstructures in early AMD. We compared retinal microstructures due to age-related changes in eyes with healthy macula in people aged 55 years or above versus those with early AMD and then determined the associations of retinal microstructural changes with AMD PRS.</p><p><strong>Methods: </strong>Participants aged 55 years or above with healthy macula and a group of people with early or intermediate AMD from the Northern Ireland Sensory Ageing study were included. 45 SNPs were included for PRS calculation.</p><p><strong>Results: </strong>A total of 470 participants with healthy macula were included (Beckman stage 0 or 1). The comparator group consisted of participants with early AMD (n = 87) or intermediate AMD (n = 48). We found that photoreceptor layer thickness decreased with age in all participants, while retinal pigment epithelium (RPE) layer thickness decreased only in those with apparently healthy macula (P < 0.05). Higher PRS was associated with thinner photoreceptor and RPE layer thickness, larger drusen size and presence of soft drusen.</p><p><strong>Conclusions: </strong>We observed a significant association between higher PRS and decreased photoreceptor layer thickness, irrespective of the macular status. Our study provides additional evidence supporting the role of genetics on pathological processes of AMD.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-surgical interventions for proliferative vitreoretinopathy-a systematic review.","authors":"Guy Hunter, Nairn Maclean, Stephanie Watson, Marcus Colyer, James Leong, Rupesh Agrawal, Scott F McClellan, Kyle E Miller, Fasika A Woreta, Matthew C Caldwell, Tom Williamson, William Gensheimer, Kara Cavuoto, Annette K Hoskin, Andrés Rousselot Ascarza, William G Felipe Dhawahir-Scala, Gangadhara Sundar, Robert A Mazzoli, Peter Shah, Malcolm Woodcock, Ferenc Kuhn, Renata Sm Gomes, Grant A Justin, Richard J Blanch","doi":"10.1038/s41433-025-03846-7","DOIUrl":"https://doi.org/10.1038/s41433-025-03846-7","url":null,"abstract":"<p><p>Proliferative Vitreoretinopathy (PVR) is the most common cause of surgical failure after retinal detachment (RD) repair, complicating up to 10% of spontaneous RD repairs and 50% of open globe injury-related RD. Early surgical intervention is currently the only intervention that reduces PVR incidence. An effective non-surgical intervention would be valuable in reducing PVR incidence and/or severity, particularly where access to surgery is limited or may be delayed. To define the evidence base for non-surgical management options to prevent and treat Proliferative Vitreoretinopathy (PVR) in retinal detachment and trauma, we searched PubMed, Clinicaltrials.gov, Medline and CINAHL for randomised controlled trials (RCTs) of non-surgical interventions to prevent or treat established PVR with no restriction on language or start date up until November 2024. All non-surgical interventions were considered with no restrictions. We considered outcomes of post-operative PVR (including retinal reattachment rate) and visual acuity and performed Risk of Bias (RoB) assessments using the Cochrane RoB2 tool. We identified 27 papers which included 1981 patients in studies of primary prevention and 1394 patients in studies of treatment of established PVR. While several studies of various agents individually demonstrated some improvements, the reviewers found concerns with RoB and the results were not replicated in the larger included studies. Multiple studies have investigated non-surgical interventions for PVR after RRD repair and trauma, but none have yet demonstrated clinically significant, repeatable benefits. Improved understanding of PVR pathobiology, along with larger prospective studies of existing preventative strategies may lead to the development of newer and more effective interventions.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual and ultrastructural analysis after splitting of recipient's Descemet membrane during Descemet membrane endothelial keratoplasty.","authors":"Maximilian Friedrich, Jasper Lind, Hyeck-Soo Son, Timur Mert Yildirim, Gerd Uwe Auffarth, Victor Aristide Augustin","doi":"10.1038/s41433-025-03872-5","DOIUrl":"https://doi.org/10.1038/s41433-025-03872-5","url":null,"abstract":"<p><strong>Background: </strong>During Descemetorhexis in Descemet Membrane Endothelial Keratoplasty (DMEK), inadvertent lamellar splitting of the recipient's Descemet membrane (DM) may occur, leaving DM remnants on the posterior corneal surface. This study investigates the influence of lamellar splitting on surgical outcome as well as the histological ultrastructure of split DMs.</p><p><strong>Methods: </strong>In this prospective, observational, single-centre cohort study 129 eyes of 102 patients were divided into two groups depending on the occurrence of intraoperative splitting. If splitting of the recipient's DM occurred, the remnants were polished via irrigation/aspiration. The primary outcome was the corrected distance visual acuity (CDVA) four months after DMEK. Secondary outcomes were central corneal thickness (CCT), thinnest corneal thickness (TCT), posterior corneal density (PCD), endothelial cell loss (ECL), and the re-bubbling rate. For histopathological analysis two removed DMs were examined using scanning and transmission electron microscopy.</p><p><strong>Results: </strong>Intraoperative splitting occurred in 36 eyes (27.9%). The postoperative CDVA in the group with splitting (0.12 ± 0.12 logMAR) did not significantly differ from the group without splitting (0.12 ± 0.12 logMAR; p = 0.96). CCT, TCT, PCD, ECL, and the re-bubbling rate also did not significantly differ between both groups (p > 0.05). In ultrastructural analysis, the split layer had a thickness of 2 µm and showed an irregular splitting interface.</p><p><strong>Conclusion: </strong>Inadvertent lamellar splitting of the recipient's DM during DMEK does not have a significant impact on the visual outcome. Therefore, polishing the DM remnants intraoperatively may address this complication in sufficient manner for optimizing visual outcomes.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}