Eye最新文献

{"title":"Geographical differences in ophthalmic trauma outcomes and risk factors: the International Globe and Adnexal Trauma Epidemiological Eye Study (IGATES).","authors":"Annette K Hoskin, Sean Ng Ming Sheng, Richard J Blanch, Anantharaman Giridhar, Marian Pauly, Mehul Shah, Alok Sen, Yunia Irawati, Eli Pradhan, Jose Romero, Manisha Agarwal, Mohammad Soleimani, Ashok Kumar Grover, Chitaranjan Mishra, Hugo H Ocampo, Anadi Khatri, Sushank Ashok Bhalerao, Purendra Bhasin, Apoorva Ayachit, Prem S Subramanian, Rekha Khandelwal, Sundaram Natarajan, Manavi D Sindal, Shakeen Singh, Nirmal Fredrick T, Jasmin Zvornicanin, Gangadhara Sundar, José Dalma-Weiszhausz, Amer Awan, Dhanashree Ratra, Kasturi Bhatacharjee, Janejit Choovuthayakorn, Samata Sharma, Yogesh Tawdekar, Chaitra Jayadev, Shanti F Boesoirie, Andres M Rousselot, William Rojas-Carabali, Stephanie L Watson, Bernett Lee, Rupesh Agrawal","doi":"10.1038/s41433-024-03581-5","DOIUrl":"https://doi.org/10.1038/s41433-024-03581-5","url":null,"abstract":"<p><strong>Objectives: </strong>Characterise the international variation in ophthalmic trauma and determine risk factors associated with visual and anatomical outcomes for low-, middle- and high-income countries.</p><p><strong>Subjects/methods: </strong>Observational multi-centre cohort study using data from the International Globe and Adnexal Trauma Epidemiological Eye Study (IGATES) from April 2014 to August 2023. Data on acute presentations of ophthalmic injury including open/closed globe injury, and/or Adnexal/orbital involvement, and/or intraocular/ intraorbital foreign body were collected and Ocular Trauma Score (OTS) was calculated. A total of 5350 patients (5557 eyes) from 31 centres in 12 countries were included. The main outcome measures included demographics, mechanism and setting of injury, and presenting and final visual outcomes. Descriptive statistics, Kruskal-Wallis tests and multinomial logistic regression (MLR) analysis are presented, with correction performed using the Hochberg method. P values less than 0.005 were significant.</p><p><strong>Results: </strong>Age, gender, presenting and final best-corrected visual acuity were all strongly associated with country (p < 0.005). Poor final visual outcomes were strongly associated with OTS predictions, type of injury (p < 0.005) and delayed presentation as well as firework injuries. High-income countries (HIC) showing reduced duration to presentation (HIC 5 h) and increased improvement in visual acuity (HIC -0.40) compared to low to middle-income countries (LMICs) (28 h) (-0.19). MLR analysis identified a significant association between countries' income classification and BCVA worse than 6/60, presence of scleral, iris, limbus injury and surgery being undertaken (p < 0.005).</p><p><strong>Conclusion: </strong>Data from 31 centres internationally identified differences in demographic trends for each country. Age was identified as a risk factor for eye injuries. Low- and middle-income countries were associated with longer delays to presentation, smaller gains in BCVA and poorer visual outcomes. IGATES provides an opportunity to collect global data on ophthalmic trauma to facilitate improved management and prevention strategies.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What have we learned from a decade treating patients with diabetic macular oedema with 0.19 mg fluocinolone acetonide intravitreal implant?","authors":"Laurent Kodjikian, Lilianne Duarte, Pankaj Singh, Maged Habib, Victor Gonzalez","doi":"10.1038/s41433-025-03692-7","DOIUrl":"https://doi.org/10.1038/s41433-025-03692-7","url":null,"abstract":"<p><p>Diabetic macular oedema [DMO] is a prevalent and sight-threatening condition among diabetic patients, which can cause irreversible blindness. Since angiogenesis and inflammation are two key elements in the etiopathogenesis of DMO, intravitreal injections of vascular endothelial growth factor inhibitors [anti-VEGF] and sustained released intravitreal corticosteroid implants are currently considered as treatments of choice. The introduction, 10 years ago, of the 0.19 mg fluocinolone acetonide [FAc] implant for treating eyes with vision impairment associated with recurrent and persistent DMO represented an important advance. Since then, two randomized-control trials and many real-world studies have shown its good efficacy/safety profile and the replicability of its treatment regimen. The FAc implant is, in general terms well tolerated, although it is associated with intraocular pressure-[IOP] and cataract-related adverse events [AEs]. Most IOP-related AEs are effectively controlled with ocular-hypotensive therapies. The objective of this paper is to review the role of FAc implant in the treatment of DMO over the 10 years since its launch, as well as its impact on clinical practice outcomes.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aflibercept 2 mg biosimilars-will they lead the Anti-VEGF biosimilar world globally.","authors":"Ashish Sharma, Se Joon Woo, Christopher Seungkyu Lee, Nilesh Kumar, Nikulaa Parachuri, Francesco Bandello, Anat Loewenstein, Baruch D Kuppermann","doi":"10.1038/s41433-025-03732-2","DOIUrl":"https://doi.org/10.1038/s41433-025-03732-2","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative models of uveitis.","authors":"Olivia S Knutson, Soyoung Choi, Simon Williams, Virginia L Calder","doi":"10.1038/s41433-025-03693-6","DOIUrl":"https://doi.org/10.1038/s41433-025-03693-6","url":null,"abstract":"<p><p>Several clinical subtypes of uveitis exist yet specific immunopathogenic mechanisms involved remain unclear. Ex vivo studies are limited by lack of fresh retinal biopsies and studies have relied on aqueous humour or peripheral blood, which may not directly reflect disease. The aim of this review is to compare the various in vivo models and review their contributions to our understanding of disease processes. These models, although unable to reflect all clinical signs, have provided insight into the contribution of genes and molecules, characterisation of effector T-cells, cell trafficking into retinal tissues, the contribution of tissue-resident myeloid cells and the mechanism(s) of action of several anti-inflammatory compounds. In vivo uveitis models have provided an excellent resource with which to study the molecular and cellular processes involved. Recent refinements in models, improved imaging, and the application of omics have greatly increased the number of readouts and translational opportunities. Future approaches with in vitro models will also be discussed.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late progressive atrophy in rubella retinopathy.","authors":"Shahanaz B Ahmed, Peter Charbel Issa","doi":"10.1038/s41433-024-03555-7","DOIUrl":"https://doi.org/10.1038/s41433-024-03555-7","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Features of intermediate and late dry age-related macular degeneration on adaptive optics ophthalmoscopy: Pinnacle Study Report 8","authors":"Ahmed M. Hagag,&nbsp;Christopher Holmes,&nbsp;Ahmer Raza,&nbsp;Sophie Riedl,&nbsp;Philipp Anders,&nbsp;Rebecca Kaye,&nbsp;Toby Prevost,&nbsp;Lars G. Fritsche,&nbsp;Daniel Rueckert,&nbsp;Hrvoje Bogunović,&nbsp;Hendrick P. N. Scholl,&nbsp;Ursula Schmidt-Erfurth,&nbsp;Andrew J. Lotery,&nbsp;Sobha Sivaprasad","doi":"10.1038/s41433-025-03696-3","DOIUrl":"10.1038/s41433-025-03696-3","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":"39 5","pages":"1020-1020"},"PeriodicalIF":2.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41433-025-03696-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI for glaucoma, Are we reporting well? a systematic literature review of DECIDE-AI checklist adherence.","authors":"Benedict Leonard-Hawkhead, Bethany E Higgins, David Wright, Augusto Azuara-Blanco","doi":"10.1038/s41433-025-03678-5","DOIUrl":"10.1038/s41433-025-03678-5","url":null,"abstract":"<p><strong>Background/objectives: </strong>This systematic literature review examines the quality of early clinical evaluation of artificial intelligence (AI) decision support systems (DSS) reported in glaucoma care. Artificial Intelligence applications within glaucoma care are increasing within the literature. For such DSS, there needs to be standardised reporting to enable faster clinical adaptation. In May 2022, a checklist to facilitate reporting of early AI studies (DECIDE-AI) was published and adopted by the EQUATOR network.</p><p><strong>Methods: </strong>The Cochrane Library, Embase, Ovid MEDLINE, PubMed, SCOPUS, and Web of Science Core Collection were searched for studies published between January 2020 and May 2023 that reported clinical evaluation of DSS for the diagnosis of glaucoma or for identifying the progression of glaucoma driven by AI. PRISMA guidelines were followed (PROSPERO registration: CRD42023431343). Study details were extracted and were reviewed against the DECIDE-AI checklist. The AI-Specific Score, Generic-Item Score, and DECIDE-AI Score were generated.</p><p><strong>Results: </strong>A total of 1,552 records were screened, with 19 studies included within the review. All studies discussed an early clinical evaluation of AI use within glaucoma care, as defined by the a priori study protocol. Overall, the DECIDE-AI adherence score was low, with authors under reporting the AI specific items (30.3%), whilst adhering well to the generic reporting items (84.7%).</p><p><strong>Conclusion: </strong>Overall, reporting of important aspects of AI studies was suboptimal. Encouraging editors and authors to incorporate the checklist will enhance standardised reporting, bolstering the evidence base for integrating AI DSS into glaucoma care workflows, thus help improving patient care and outcomes.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood omega-3 biomarkers, diabetic retinopathy and retinal vessel status in patients with type 1 diabetes.","authors":"Aleix Sala-Vila, Irene Vinagre, Montserrat Cofán, Iolanda Lázaro, Anibal Alé-Chilet, Marina Barraso, Teresa Hernandez, William S Harris, Javier Zarranz-Ventura, Emilio Ortega","doi":"10.1038/s41433-025-03705-5","DOIUrl":"https://doi.org/10.1038/s41433-025-03705-5","url":null,"abstract":"<p><strong>Background/objectives: </strong>Clinical research on dietary omega-3 fatty acids and retinal health in type 1 diabetes (T1D) is scarce. In patients with T1D, we examined the associations between blood biomarkers of marine omega-3 (which reflect their dietary intake) and prevalent diabetic retinopathy (DR), and retinal microvascular data obtained through optical coherence tomography angiography (OCTA).</p><p><strong>Subjects/methods: </strong>Exploratory, cross-sectional sub-study of a prospective, consecutive, large-scale OCTA study conducted in a longitudinal cohort (ClinicalTrials.gov NCT03422965). We used baseline data from 188 consecutive patients with T1D and 88 controls. We determined blood omega-3 biomarkers (eicosapentaenoic [EPA], docosapentaenoic [DPA] and docosahexaenoic [DHA] acids) by gas-chromatography. Ocular data included DR grading, and 6 × 6 mm OCTA scans to obtain macular vessel density and perfusion density, and foveal avascular zone area, perimeter, and circularity.</p><p><strong>Results: </strong>Patients with T1D, regardless of DR stage, showed significantly lower blood levels of EPA, DHA, DHA, and EPA + DHA than non-diabetic controls (P < 0.001, all cases). In multivariate models in patients with T1D, higher EPA was associated with a lower prevalence of DR (P = 0.044); and increasing proportions of DPA, DHA, EPA + DHA, and total marine omega-3 fatty acids related to a higher vessel and perfusion densities in the macula (P values from 0.014 to 0.050).</p><p><strong>Conclusions: </strong>In patients with T1D, higher blood omega-3 status related to lower DR grades and preserved retinal perfusion. Our results, which are consistent with the current model of the pathogenesis of DR and data from experimental models, add to the notion of marine-derived omega-3 fatty acids as a healthy fat.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"I see blue.","authors":"Shahzaib Rehan, Mario Saldanha","doi":"10.1038/s41433-025-03717-1","DOIUrl":"https://doi.org/10.1038/s41433-025-03717-1","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iris melanoma in an Asian Indian with multifocal iris nevi.","authors":"Vijitha S Vempuluru, Swathi Kaliki","doi":"10.1038/s41433-025-03709-1","DOIUrl":"https://doi.org/10.1038/s41433-025-03709-1","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}