Eye最新文献

{"title":"Understanding the relationship between astigmatism, posterior cornea and corneal thickness: a move to total corneal power.","authors":"Mayank A Nanavaty","doi":"10.1038/s41433-025-03742-0","DOIUrl":"https://doi.org/10.1038/s41433-025-03742-0","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Nerve fibre organisation in the human optic nerve and chiasm: what do we really know?","authors":"Pratap R Pawar, Joshua Booth, Andrew Neely, Gawn McIlwaine, Christian J Lueck","doi":"10.1038/s41433-025-03800-7","DOIUrl":"https://doi.org/10.1038/s41433-025-03800-7","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant conjunctival squamous papilloma in Stevens-Johnson Syndrome.","authors":"Manasi Tripathi, Aiswarya Sasi, Rajesh Sinha","doi":"10.1038/s41433-025-03795-1","DOIUrl":"https://doi.org/10.1038/s41433-025-03795-1","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the 1-year efficacy of epithelium-off and transepithelial accelerated corneal collagen crosslinking in adolescent keratoconus.","authors":"Yuhong Tang, Jinling Jiang, Chaoju Yang, Hongyu Yin, Yunzhen Fei","doi":"10.1038/s41433-025-03784-4","DOIUrl":"https://doi.org/10.1038/s41433-025-03784-4","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the clinical efficacy of epithelium-off and transepithelial accelerated corneal collagen crosslinking (ACXL) in adolescent keratoconus.</p><p><strong>Methods: </strong>In this prospective observational study with a 1-year follow-up, 60 patients aged 16-26 years (60 eyes) with keratoconus were assigned to two groups: the epithelium-off ACXL group (30 patients, 30 eyes) and the transepithelial ACXL group (30 patients, 30 eyes). Patients were evaluated preoperatively and at 7 days, 1 month, 3 months, 6 months, and 12 months post-treatment. The measurements included visual acuity, corneal parameters, and corneal endothelium parameters. Baseline data and treatment effect were compared using the t-test or Wilcoxon rank-sum test for continuous variables and the chi-square test for categorical variables. Within-group comparisons used paired t-tests or paired rank-sum tests.</p><p><strong>Results: </strong>At 12 months postoperatively, the treatment groups showed statistically significant differences in central corneal thickness (IOLMaster), thinnest point corneal thickness (topography), thickness (topography), central corneal thickness, corneal thickness on optical coherence tomography, deformation amplitude (DA), first applanation time, first applanation velocity, second applanation time, second applanation velocity, peak distance (PD), high-contrast acuity, stiffness parameter at the first applanation, and comprehensive refraction (p < 0.001). No differences were observed between the groups in any other parameters before or after treatment.</p><p><strong>Conclusions: </strong>Both epithelium-off and transepithelial ACXL effectively treat keratoconus. Transepithelial ACXL is slightly inferior to epithelium-off ACXL in maximum corneal curvature but superior in improving corneal thickness and DA parameters. Further studies are necessary to verify the efficacy, safety, and long-term stability of transepithelial ACXL in treating keratoconus.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing geographic and institutional disparities in United States diabetic eye disease clinical trials (2000-2023).","authors":"Jainam Shah, Sachin Pathuri, Jason Zheng, Ibrahim Furkan Acar, Elanit Safaei, Sailesh Tummala","doi":"10.1038/s41433-025-03791-5","DOIUrl":"https://doi.org/10.1038/s41433-025-03791-5","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A decade-long review: insights into diagnosis and disease evolution of uveitis from a single-center study.","authors":"Gunjan Sharma, Atul Arora, William Rojas-Carabali, Bernett Lee, Amod Gupta, Reema Bansal, Mohit Dogra, Deeksha Katoch, Aman Sharma, Ankur Jindal, Deepti Suri, Surjit Singh, Rupesh Agrawal, Vishali Gupta","doi":"10.1038/s41433-025-03772-8","DOIUrl":"https://doi.org/10.1038/s41433-025-03772-8","url":null,"abstract":"<p><strong>Purpose: </strong>To analyse the evolution of uveitis diagnosis over a 10-year period, emphasizing the change in etiological diagnosis, and the factors associated with recurrences.</p><p><strong>Design: </strong>Retrospective chart review.</p><p><strong>Methods: </strong>A total of 15,000 patients with uveitis presented at our tertiary care institute in North India between 1992 and 2023. Of these,123 patients completed 10-year follow-up and were included in the study. The data of patients was collected on an offline purpose-built uveitis registry portal: Ocular Autoimmune Systemic Inflammatory and Infectious Study(OASIS).</p><p><strong>Results: </strong>The study included 123 patients (48.78% males; mean age: 29.11 ± 15.22 years). The most common anatomical and etiological diagnosis at presentation were anterior (49/123,34.96%) and idiopathic(59/123,47.97%) uveitis respectively. At the end of 10 years, anterior uveitis remained the most common anatomical diagnosis (43/123,39.83%) while the most common etiological diagnosis was immune-mediated uveitis (50/123,40.65%). An etiological diagnosis could be established in 50.85% (30/59) of patients initially labelled as idiopathic. Tuberculous uveitis (39/44, 88.63%) and Juvenile Idiopathic Arthritis associated uveitis (16/49, 32.65%) were the commonest infectious and immune-mediated aetiologies at the 10-year follow-up. Ninety-six (80.67%) patients experienced multiple episodes of ocular inflammation with a mean recurrence rate of 0.386 ± 0.24 recurrences/year. Anterior uveitis (p = 0.01), the change in etiological diagnosis after the first year (p = 0.03), positive HLA-B27 at baseline (p = 0.04), and the diagnosis of a systemic disease prior to the onset of uveitis were associated with higher recurrences rates (p = 0.03).</p><p><strong>Conclusion: </strong>Over 10-year of follow-up, half of the uveitis diagnoses evolved from idiopathic to specific infectious or immune-mediated aetiologies. Our results indicate that patients with a high recurrence rate may benefit from re-evaluation to find the definitive cause of uveitis.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143788151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The widening landscape of synthetic incretin treatment: possible association of ischaemic optic neuropathy risk and the need for a cautious approach.","authors":"Maria S Varughese, Sushuma Kalidindi","doi":"10.1038/s41433-025-03776-4","DOIUrl":"https://doi.org/10.1038/s41433-025-03776-4","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Polygenic Risk Score Impact on Visual Function in Older Individuals with Healthy Macula: The Northern Ireland Sensory Ageing Study.","authors":"Fangyao Tang, Ruth E Hogg, Bethany E Higgins, David M Wright, Laura Smyth, Sobha Sivaprasad","doi":"10.1038/s41433-025-03773-7","DOIUrl":"10.1038/s41433-025-03773-7","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dry eye disease treatment following refractive surgery among young patients: a population-based study.","authors":"Itay Nitzan, Dan Heller, Clara C Chan, Michael Mimouni, Margarita Safir","doi":"10.1038/s41433-025-03783-5","DOIUrl":"https://doi.org/10.1038/s41433-025-03783-5","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the demand for dry eye disease (DED) lubricating eye drop treatment following refractive surgery among young patients.</p><p><strong>Methods: </strong>This study involved Israeli adolescents and young adults aged 16-20 years who underwent systematic medical evaluations from 2011 to 2019. Refractive surgery status was determined based on medical records. Lubricating eye drop usage was monitored through computerized dispensation data over a three-year period. Regression models, stratified by sex and adjusted for sociodemographic variables, were used.</p><p><strong>Results: </strong>Among 591,919 individuals (57.4% male, mean age 17.2 years), 4571 (0.8%) underwent refractive surgery. Lubricating eye drop usage was observed in 1.4% of men and 2.3% of women, with higher proportions in the refractive surgery group (4.0% vs. 1.4% and 9.5% vs. 2.3% for men and women, respectively; p < 0.001). Adjusted odds ratios (aORs) for increased DED treatment durations in men were 2.34 (95% CI 1.94-2.83) for ≤3 months, 5.22 (95% CI 3.43-7.94) for 3 to 12 months, and 5.79 (95% CI 3.69-9.09) for over 12 months. For women, aORs were 3.68 (95% CI 2.50-5.41) for ≤3 months, 6.06 (95% CI 2.50-14.73) for 3-12 months, and 11.57 (95% CI 4.74-28.25) for over 12 months.</p><p><strong>Conclusions: </strong>Young patients after refractive surgery are significantly more likely to require DED lubricating eye drops for over a year following the procedure.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Iris metastasis of neuroblastoma in a 3-year-old boy.","authors":"Aoxiang Wang, Yu Tian","doi":"10.1038/s41433-025-03768-4","DOIUrl":"https://doi.org/10.1038/s41433-025-03768-4","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}