Eye最新文献 - Book学术

Coral-like branching of conjunctival intracorneal neoplasia: a 40-day progression. 结膜角膜内肿瘤的珊瑚样分支：40天的进展。

IF 2.8 3区医学

Eye Pub Date : 2025-07-04 DOI: 10.1038/s41433-025-03905-z

Hitoshi Hayashi, Hiroshi Eguchi, Shizuka Koh

引用次数: 0

Infographic: landmark trials in neuro-ophthalmology-results of the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT). 信息图：神经眼科的里程碑式试验——特发性颅内高压治疗试验（IIHTT）的结果。

IF 2.8 3区医学

Eye Pub Date : 2025-07-04 DOI: 10.1038/s41433-025-03907-x

Michael Lowe, Gabriele Berman, Mark Thaller, Susan P Mollan

引用次数: 0

Treatment of central serous chorioretinopathy: new options for an old disease. 中枢性浆液性脉络膜视网膜病变的治疗：一种老病的新选择。

IF 2.8 3区医学

Eye Pub Date : 2025-07-04 DOI: 10.1038/s41433-025-03894-z

Yoon Jeon Kim, Sobha Sivaprasad, Tariq Aslam, Polona Jaki Mekjavić, Vilma Jūratė Balčiūnienė, Linda Visser, Antonia M Joussen, Young Hee Yoon, Timothy Y Y Lai, Annabelle A Okada

{"title":"Treatment of central serous chorioretinopathy: new options for an old disease.","authors":"Yoon Jeon Kim, Sobha Sivaprasad, Tariq Aslam, Polona Jaki Mekjavić, Vilma Jūratė Balčiūnienė, Linda Visser, Antonia M Joussen, Young Hee Yoon, Timothy Y Y Lai, Annabelle A Okada","doi":"10.1038/s41433-025-03894-z","DOIUrl":"https://doi.org/10.1038/s41433-025-03894-z","url":null,"abstract":"Central serous chorioretinopathy (CSC) is a common ocular disease that causes vision loss, particularly in people of working age. Although it was first described over a century ago, research has expanded in recent years, transforming the understanding and management of this complex condition. Here, we propose clinical recommendations for the treatment and management of CSC, based on evidence from the published literature and the consensus of an international group of retinal experts. Recent evidence describing the pathogenesis of and risk factors for CSC focuses on possible dysfunction of the choroid and retinal pigment epithelium, and the role of corticosteroids. It is suggested that CSC lies within the spectrum of pachychoroid disorders that share the characteristic of thickened choroidal tissue. Available evidence supports half-dose (or half-fluence) verteporfin photodynamic therapy as the treatment of choice for CSC to reduce choroidal hyperpermeability. A subset of patients with chronic CSC can develop choroidal neovascularisation, and these patients should be treated with intravitreal anti-vascular endothelial growth factor agents. Finally, posterior multifocal pigment epitheliopathy is a recognised variant of CSC that may progress to large areas of exudative retinal detachment. We propose a step-wise chart for clinical decision-making in the management and treatment of CSC. New data on long-term visual outcomes and the pathogenesis of CSC in relation to the pachychoroid disease spectrum provide a better understanding to inform our management of this disease.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in corneal transplantation. 角膜移植研究进展。

IF 2.8 3区医学

Eye Pub Date : 2025-07-04 DOI: 10.1038/s41433-025-03898-9

Christopher Tay, Harika Reddy, Jodhbir S Mehta

{"title":"Advances in corneal transplantation.","authors":"Christopher Tay, Harika Reddy, Jodhbir S Mehta","doi":"10.1038/s41433-025-03898-9","DOIUrl":"https://doi.org/10.1038/s41433-025-03898-9","url":null,"abstract":"For many corneal diseases, transplantation is the gold standard for curative treatment and restoration of vision. Penetrating keratoplasty (PKP), performed by Zirm in 1905, was the first successful corneal transplantation procedure. Since then, relentless advancement in the field has occurred, most importantly with the development of deep anterior lamellar keratoplasty (DALK), Descemet stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK), which have been rapidly increasing in usage and are poised to take over PKP in prevalence and effectiveness in treating specific stromal and endothelial pathologies. The biggest issues currently facing this field are the lack of availability of donor corneas and lack of accessibility of the procedure to many areas of the world. Recent and future advancements are focused on substitutes to increase the amount of graft material for use and technological developments to streamline keratoplasty techniques, making them more effective, easier to perform and associated with less complications. Bio-engineered corneas, cell-based therapies and regenerative medicine can create grafts through various mechanisms: acellular, synthetic scaffolds and medical therapies to promote endogenous cell regeneration or exogenous cultivation of corneal tissues from stem-cells. Keratoplasty has also been refined by the introduction of femtosecond laser (FSL), which when combined with intra-operative optical coherence tomography (iOCT) allows for finer cuts and novel techniques which can improve the outcomes from PKP, DALK and DMEK.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wide-field OCTA quantified peripheral nonperfusion areas predict the risk of subclinical neovascularization. 宽视场OCTA量化外周非灌注区预测亚临床新生血管的风险。

IF 2.8 3区医学

Eye Pub Date : 2025-07-02 DOI: 10.1038/s41433-025-03891-2

An-Lun Wu, Yukun Guo, Tristan T Hormel, Christina J Flaxel, Merina Thomas, Steven T Bailey, Dong-Wouk Park, Yali Jia, Thomas S Hwang

{"title":"Wide-field OCTA quantified peripheral nonperfusion areas predict the risk of subclinical neovascularization.","authors":"An-Lun Wu, Yukun Guo, Tristan T Hormel, Christina J Flaxel, Merina Thomas, Steven T Bailey, Dong-Wouk Park, Yali Jia, Thomas S Hwang","doi":"10.1038/s41433-025-03891-2","DOIUrl":"https://doi.org/10.1038/s41433-025-03891-2","url":null,"abstract":"Purpose: To demonstrate the capabilities of single-shot widefield swept-source OCT angiography (SS-OCTA) in detecting subclinical retinal neovascularization (RNV), quantifying nonperfusion areas (NPAs), and exploring the relations between NPAs and subclinical RNV in eyes graded as nonproliferative diabetic retinopathy (NPDR).Methods: Eyes clinically graded as moderate to severe NPDR underwent SS-OCTA imaging. Expert graders identified subclinical RNV, defined as vessels with a flow signal above the internal limiting membrane on OCTA that are not visible on dilated fundus examination. This identification was based on a combination of en face OCT, en face OCTA, and cross-sectional OCTA overlaid on OCT. NPA index was calculated as a percentage of automatically quantified NPA over the area in the posterior pole, the mid-periphery, and the total imaged area.Results: Totally 37 eyes, including 21 had severe NPDR and 16 had moderate NPDR. Subclinical RNV was present in 14 eyes (37.8%). The eyes with RNV had significantly higher mid-peripheral and total NPA indices but not in the posterior region (mid-peripheral NPA: 31.97% ± 7.02% vs. 24.80% ± 6.60%, p = 0.041; total NPA: 27.96% ± 6.36% vs. 21.61% ± 5.65%, p = 0.046; all values are reported as mean ± standard deviation). The total NPA index showed the highest diagnostic accuracy for subclinical RNV detection (AUC: 0.761; 95% CI, 0.592-929, with a sensitivity of 64.3% and a specificity of 87% at a cutoff value of 28.84%).Conclusion: Widefield SS-OCTA can detect subclinical RNV. The eyes with higher mid-peripheral NPA indices are more likely to have subclinical RNV, indicating that the NPA index may be a useful biomarker for identifying eyes at risk of RNV.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

One-year outcome of intense pulsed light therapy for refractory meibomian gland dysfunction in patients continuously exposed to topical glaucoma medications: a comparative study. 持续暴露于局部青光眼药物的患者，强脉冲光治疗顽固性睑板腺功能障碍的一年结果：一项比较研究。

IF 2.8 3区医学

Eye Pub Date : 2025-07-02 DOI: 10.1038/s41433-025-03886-z

Chi-Chun Yang, Yu-Chieh Ko, De-Kuang Hwang, Meng-Jou Chen, Nai-Wen Fan

{"title":"One-year outcome of intense pulsed light therapy for refractory meibomian gland dysfunction in patients continuously exposed to topical glaucoma medications: a comparative study.","authors":"Chi-Chun Yang, Yu-Chieh Ko, De-Kuang Hwang, Meng-Jou Chen, Nai-Wen Fan","doi":"10.1038/s41433-025-03886-z","DOIUrl":"https://doi.org/10.1038/s41433-025-03886-z","url":null,"abstract":"Background: To evaluate the one-year effect of intense pulsed light (IPL) for refractory meibomian gland dysfunction (MGD) between patients treated with and without topical hypotensive agents.Methods: This retrospective study included 21 MGD eyes of 21 glaucoma patients (age, 64.38 ± 13.74 years) and 21 MGD eyes of 21 non-glaucoma patients (age, 63.90 ± 13.50 years). Both arms received IPL therapy with meibomian gland expression (MGX). Propensity score matching ensured baseline comparability. Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire, tear film breakup time (TBUT), lid telangiectasia, corneal staining, meibum quality and expressibility were assessed at baseline, 3-, 6-, 9- and 12-months post-treatment.Results: Both groups showed significant improvement in SPEED score and TBUT at 9 months, but only the non-glaucoma group maintained these improvements at 12 months (P < 0.01). While meibum quality improved in both groups at 12 months, significant improvement in lid telangiectasia and meibum expressibility was observed only in the non-glaucoma group. At 12 months, the non-glaucoma group showed less lid telangiectasia than the glaucoma group (P = 0.009). No other intergroup differences were found in other outcomes. Neither group showed significant improvement in corneal staining throughout the follow-up period.Conclusions: IPL therapy is effective for treating refractory MGD in both glaucoma and non-glaucoma patients, with significant improvements in dry eye symptoms, tear film stability and meibum quality. However, patients on continuous hypotensive agents showed less improvement in lid telangiectasia at 12 months, suggesting that chronic hypotensive medication use may affect treatment efficacy.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144552778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic utility of artificial intelligence software through non-mydriatic digital retinography in the screening of diabetic retinopathy: an overview of reviews. 人工智能软件在糖尿病视网膜病变筛查中的应用：综述综述。

IF 2.8 3区医学

Eye Pub Date : 2025-07-01 Epub Date: 2025-04-29 DOI: 10.1038/s41433-025-03809-y

Agustín Ciapponi, Jamile Ballivian, Carolina Gentile, Jhonatan R Mejia, Jessica Ruiz-Baena, Ariel Bardach

{"title":"Diagnostic utility of artificial intelligence software through non-mydriatic digital retinography in the screening of diabetic retinopathy: an overview of reviews.","authors":"Agustín Ciapponi, Jamile Ballivian, Carolina Gentile, Jhonatan R Mejia, Jessica Ruiz-Baena, Ariel Bardach","doi":"10.1038/s41433-025-03809-y","DOIUrl":"10.1038/s41433-025-03809-y","url":null,"abstract":"Objective: To evaluate the capability of artificial intelligence (AI) in screening for diabetic retinopathy (DR) utilizing digital retinography captured by non-mydriatic (NM) ≥45° cameras, focusing on diagnosis accuracy, effectiveness, and clinical safety.Methods: We performed an overview of systematic reviews (SRs) up to May 2023 in Medline, Embase, CINAHL, and Web of Science. We used AMSTAR-2 tool to assess the reliability of each SR. We reported meta-analysis estimates or ranges of diagnostic performance figures.Results: Out of 1336 records, ten SRs were selected, most deemed low or critically low quality. Eight primary studies were included in at least five of the ten SRs and 125 in less than five SRs. No SR reported efficacy, effectiveness, or safety outcomes. The sensitivity and specificity for referable DR were 68-100% and 20-100%, respectively, with an AUROC range of 88 to 99%. For detecting DR at any stage, sensitivity was 79-100%, and specificity was 50-100%, with an AUROC range of 93 to 98%.Conclusions: AI demonstrates strong diagnostic potential for DR screening using NM cameras, with adequate sensitivity but variable specificity. While AI is increasingly integrated into routine practice, this overview highlights significant heterogeneity in AI models and the cameras used. Additionally, our study enlightens the low quality of existing systematic reviews and the significant challenge of integrating the rapidly growing volume of emerging evidence in this field. Policymakers should carefully evaluate AI tools in specific contexts, and future research must generate updated high-quality evidence to optimize their application and improve patient outcomes.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"2083-2089"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of effectiveness of geographic atrophy automatic segmentation with different imaging methods. 不同成像方法对地理萎缩自动分割的有效性比较。

IF 2.8 3区医学

Eye Pub Date : 2025-07-01 Epub Date: 2025-04-12 DOI: 10.1038/s41433-025-03794-2

Maria Cristina Savastano, Emanuele Crincoli, Alfonso Savastano, Alessandro Gravina, Matteo Mario Carlà, Clara Rizzo, Raphael Kilian, Stanislao Rizzo

{"title":"Comparison of effectiveness of geographic atrophy automatic segmentation with different imaging methods.","authors":"Maria Cristina Savastano, Emanuele Crincoli, Alfonso Savastano, Alessandro Gravina, Matteo Mario Carlà, Clara Rizzo, Raphael Kilian, Stanislao Rizzo","doi":"10.1038/s41433-025-03794-2","DOIUrl":"10.1038/s41433-025-03794-2","url":null,"abstract":"Purpose: To compare geographic atrophy (GA) size measured with fundus autofluorescence (FAF), near-infrared (N-IR) imaging, retromode (RM) imaging and optical coherence tomography angiography (OCTA) imaging and to compare accuracy of artificial intelligence(AI)-based automatic segmentation of GA with each method.Methods: Available good quality FAF, N-IR- RM and OCTA images acquired on the same date for each patient diagnosed with GA from 2022 to 2024 were retrospectively collected. Seventy(70)% of the images were used to train a Trainable Weka Segmenter (v 3.3.2) based on manual segmentation of GA and spurious areas performed by 2 different blinded expert graders for each of the 4 imaging modalities. For the remaining 30%(testing set), automatic measurement and manual measurement were compared to determine accuracy of the segmentation.Results: A total of 157 eyes were included. Mean ground truth GA area (graders' manual contouring), mean automatic area and mean spurious area of testing set were significantly different with the 4 techniques(respectively p < 0.001, p < 0.001 and p = 0.002). Intraclass correlation coefficient(ICC) between manual and automatic measurements was 0.82 (0.78-0.84) for FAF model, 0.81 (0.78-0.82) for N-IR model, 0.67 (0.64-0.71) for RM model and 0.77 (0.73-0.81) for OCTA model.Conclusion: We report very good performance of automatic segmentation performed on FAF, N-IR and OCTA. A slight overestimation of GA area with automatic measurements would be considered when assessing GA area on FAF and N-IR imaging. RM imaging should not be considered as a valid method for automatic GA area assessment due to superiority of other available enface imaging techniques.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"2003-2007"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoresection of choroidal melanoma: practical and safety considerations. 脉络膜黑色素瘤的内切术：实用性和安全性考虑。

IF 2.8 3区医学

Eye Pub Date : 2025-07-01 Epub Date: 2025-05-06 DOI: 10.1038/s41433-025-03827-w

Rodrigo Anguita, Jens Folke Kiilgaard

引用次数: 0

Retinal optical coherence tomography angiography (OCTA) biomarkers of cardiovascular disease: a review article. 视网膜光学相干断层扫描血管造影（OCTA）心血管疾病的生物标志物：综述文章。

IF 2.8 3区医学

Eye Pub Date : 2025-07-01 Epub Date: 2025-05-14 DOI: 10.1038/s41433-025-03780-8

Simon D Archambault, Omar Abu-Qamar, David Biery, Antonio Yaghy, Brittany Weber, Nadia K Waheed

引用次数: 0