Eye最新文献 - Book学术

Exudative retinal detachment as a presentation of systemic lupus erythematosus (SLE).

IF 2.8 3区医学

Eye Pub Date : 2025-03-27 DOI: 10.1038/s41433-025-03758-6

Ashish Markan, Manasi Tripathi, Vipin Rana, Amit Nandan Tripathi

引用次数: 0

The hidden sting: unmasking corneal ice rink sign in a bee sting injury.

IF 2.8 3区医学

Eye Pub Date : 2025-03-27 DOI: 10.1038/s41433-025-03771-9

Agrima Bhatia, Amit Nandan Tripathi, Vipin Rana, Ranjit Goenka, Utkarsh Roodkee

引用次数: 0

LLM-assisted medical documentation: efficacy, errors, and ethical considerations in ophthalmology.

IF 2.8 3区医学

Eye Pub Date : 2025-03-27 DOI: 10.1038/s41433-025-03767-5

Shrirajh Satheakeerthy, Daniel Jesudason, James Pietris, Stephen Bacchi, Weng Onn Chan

引用次数: 0

Correlation between quality of vision and clinical and structural parameters in patients with Autosomal Dominant Optic Atrophy.

IF 2.8 3区医学

Eye Pub Date : 2025-03-26 DOI: 10.1038/s41433-025-03762-w

Anna Camós-Carreras, Marc Figueras-Roca, Salut Albà-Arbalat, Rafel Alcubierre, Marta Saint-Gerons, Bernardo Sánchez-Dalmau

{"title":"Correlation between quality of vision and clinical and structural parameters in patients with Autosomal Dominant Optic Atrophy.","authors":"Anna Camós-Carreras, Marc Figueras-Roca, Salut Albà-Arbalat, Rafel Alcubierre, Marta Saint-Gerons, Bernardo Sánchez-Dalmau","doi":"10.1038/s41433-025-03762-w","DOIUrl":"https://doi.org/10.1038/s41433-025-03762-w","url":null,"abstract":"Background: Autosomal Dominant Optic Atrophy (ADOA) is a hereditary condition caused by mutations in the OPA1 gene, leading to progressive degeneration of the optic nerve fibres and subsequent visual decline. Despite advances in understanding its genetic and clinical aspects, the impact of ADOA on vision-related quality of life (VRQoL) remains poorly characterized.Subjects/methods: This cross-sectional study aimed to evaluate VRQoL in 27 patients with molecularly confirmed ADOA using the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and its 10-item Neuro-Ophthalmic Supplement. Clinical and structural parameters, including visual acuity, colour vision, macular volume, and ganglion cell complex thickness, were assessed to explore their association with VRQoL scores.Results: Significant reduction in VRQoL, with mean composite scores of 74.1 (NEI-VFQ-25) and 69.9 (neuro-ophthalmic supplement) was observed. General vision, near activities, and distance activities were the most affected domains, while colour vision surprisingly scored higher than expected. Multivariate analysis revealed that best-corrected visual acuity (BCVA) to be independently associated with VFQ-25 composite (ß coefficient -66.46; p < 0.001), VFQ-25 neuroophthalmology (ß coefficient -57.13; p < 0.001) and 4 of the 12 subscales. Additionally, macular vessel density correlated with specific subscales such as dependency and colour vision.Conclusions: These findings highlight the significant functional burden of ADOA on patients and underscore the importance of clinical parameters such as BCVA and peripapillary retinal nerve fibre layer in assessing the quality of life. The study suggests that preserving visual acuity should be a primary therapeutic target in ADOA management, as well as a key for monitoring and guiding future therapeutic interventions.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anterior segment dysgenesis as a feature of Neurofibromatosis-I.

IF 2.8 3区医学

Eye Pub Date : 2025-03-26 DOI: 10.1038/s41433-025-03781-7

Manasi Tripathi, Vidit Bansal, Rajesh Sinha

引用次数: 0

Descemet membrane endothelial keratoplasty with or without overnight admission.

IF 2.8 3区医学

Eye Pub Date : 2025-03-25 DOI: 10.1038/s41433-025-03754-w

Giulia Coco, Luca Pagano, Alfredo Borgia, Mahmoud Ahmed, Davide Tucci, Kunal A Gadhvi, Stephen B Kaye, Vito Romano

{"title":"Descemet membrane endothelial keratoplasty with or without overnight admission.","authors":"Giulia Coco, Luca Pagano, Alfredo Borgia, Mahmoud Ahmed, Davide Tucci, Kunal A Gadhvi, Stephen B Kaye, Vito Romano","doi":"10.1038/s41433-025-03754-w","DOIUrl":"https://doi.org/10.1038/s41433-025-03754-w","url":null,"abstract":"Objective: To compare visual outcomes and show postoperative complication rates of Descemet Membrane Endothelial Keratoplasty (DMEK) with or without overnight admission.Methods: Retrospective analysis of DMEK surgeries performed at the Royal Liverpool University Hospital from 2018 to 2023. Data on demographics, surgical details, intraoperative and postoperative complications and admission type were collected. Visual outcomes and complication rates of surgeries with or without overnight admission were evaluated.Results: 344 eyes were included with mean patients' age of 72.1 ± 9.7 years (range 37.4-96.6 years). After surgery, 61.3% of patients (n = 211) were hospital-admitted for a one-night stay while 38.7% (n = 133) were home-discharged on the same day. Intraoperative complications occurred in 8.7% of patients and postoperative complications in 5.8%, with no difference with or without overnight admission (p = 0.308 and p = 0.412, respectively). There was no difference in the improvement in visual acuity (0.43 ± 0.6 and 0.45 ± 0.6 logMAR; range: -1.82; +2.38 logMAR) between both groups (p = 0.984), and no difference was found in postoperative rebubbling rate between both groups (30.8% in hospital-admitted and 31.6% in home-discharged; p = 0.926). Multivariate logistic regression showed no association between overnight admission and DMEK rebubbling rate (p = 0.555). However, postoperative complications, triple procedure and recipient age were all significant factors increasing DMEK rebubbling requirement (p < 0.05). Home-discharged patients had a risk ratio of 1.03 (95% CI 0.74-1.41; p = 0.926) for rebubbling and 0.68 (95% CI 0.28-1.372; p = 0.412) for postoperative complications compared to their hospital-admitted counterpart.Conclusions: Visual outcomes and postoperative complications did not show any significant difference in DMEK surgeries with or without overnight admission.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pupil Wizard: an app to enhance knowledge of pupillary abnormalities.

IF 2.8 3区医学

Eye Pub Date : 2025-03-25 DOI: 10.1038/s41433-025-03763-9

Øystein Kalsnes Jørstad, Andrew G Lee

引用次数: 0

Spectrum of presentation of intraocular metastases from cutaneous melanoma in the era of immunotherapy and targeted therapies.

IF 2.8 3区医学

Eye Pub Date : 2025-03-25 DOI: 10.1038/s41433-025-03753-x

Stéphanie Lemaître, Amit K Arora, Gordon Robert Hay, Mandeep S Sagoo

{"title":"Spectrum of presentation of intraocular metastases from cutaneous melanoma in the era of immunotherapy and targeted therapies.","authors":"Stéphanie Lemaître, Amit K Arora, Gordon Robert Hay, Mandeep S Sagoo","doi":"10.1038/s41433-025-03753-x","DOIUrl":"https://doi.org/10.1038/s41433-025-03753-x","url":null,"abstract":"Background: Intraocular metastases from cutaneous melanoma are rare. Diagnosis can be challenging and there is currently no consensus on treatment. However, with the increasing incidence of this cancer and improved survival of patients treated with targeted BRAF-MEK inhibitors and checkpoint inhibitors, it is likely that more cases will be referred to ocular oncology clinics.Subjects: Single-centre retrospective study. We included all the patients diagnosed with intraocular metastases from cutaneous melanoma seen between 2017 and 2022.Results: The first patient had bilateral choroidal metastases and unilateral vitreous cells (treated with external beam radiotherapy and immunotherapy), the second had unilateral amelanotic vitreous metastasis (treated with vitrectomy and BRAF-MEK inhibitors) and the third had bilateral multifocal choroidal metastases (treated with BRAK-MEK inhibitors followed by immunotherapy). The fourth patient (previously reported) had unilateral anterior segment and vitreous metastases (treated with immunotherapy and enucleation). Interestingly, two patients had a history of uveitis in the affected eye, unrelated to the ocular metastases. All four patients had synchronous systemic metastases.Conclusions: The diagnosis of intraocular metastases from cutaneous melanoma is generally clinical but it is sometimes challenging because of possible masquerade syndromes. The presence of other extraocular metastatic sites is an indicator of the diagnosis. Cytopathologic proof combined with genetic analysis is sometimes necessary for diagnosis, especially with amelanotic vitreous debris or in rare cases where systemic screening is negative. New treatments with targeted BRAF-MEK inhibitors and checkpoint inhibition may avoid external beam radiotherapy and enucleation in some patients.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Descemet schisis post RK.

IF 2.8 3区医学

Eye Pub Date : 2025-03-24 DOI: 10.1038/s41433-025-03760-y

Abhilasha Sanoria, Ritu Arora, Rushad Shroff, Palak Gupta, Deepender Chauhan

引用次数: 0

Risk of primary acquired nasolacrimal duct obstruction among gastroesophageal reflux disease patients: a global population-based study.

IF 2.8 3区医学

Eye Pub Date : 2025-03-22 DOI: 10.1038/s41433-025-03759-5

Yung-Yu Chu, Chung-Han Ho, Yi-Chen Chen, Shu-Chun Kuo, Po-Yu Lee, Yu-Shiuan Lin

{"title":"Risk of primary acquired nasolacrimal duct obstruction among gastroesophageal reflux disease patients: a global population-based study.","authors":"Yung-Yu Chu, Chung-Han Ho, Yi-Chen Chen, Shu-Chun Kuo, Po-Yu Lee, Yu-Shiuan Lin","doi":"10.1038/s41433-025-03759-5","DOIUrl":"https://doi.org/10.1038/s41433-025-03759-5","url":null,"abstract":"Objectives: The relationship between gastroesophageal reflux disease (GERD) and primary acquired nasolacrimal duct obstruction (PANDO) remains underexplored, and large-scale global studies are lacking. This study aims to evaluate the association between GERD and PANDO on an international scale.Methods: This retrospective cohort study utilized data from the TriNetX Global Collaborative Network, encompassing over 157 million patients across 18 countries. Patients with GERD and controls without GERD were included from January, 2004, through November, 2024. Patients with pre-existing lacrimal passage disorders were excluded. The primary outcome was the incidence of PANDO. Patients were followed for up to 20 years. Propensity score matching was employed to balance baseline characteristics. Cox proportional hazards regression was used to calculate hazard ratios (HRs), and Kaplan-Meier analysis was conducted to assess the cumulative incidence.Results: After matching, 876,330 patients were included in both the GERD and control cohorts. GERD was associated with a significantly higher risk of PANDO (HR: 2.49; 95% CI: 2.18-2.85; P < 0.001). Risk stratification analyses demonstrated greater risks in females (HR: 2.74; 95% CI: 2.32-3.24) and in older age groups (HR for ≥60 years: 3.12; 95% CI: 2.59-3.74). Comorbidities such as diabetes, dyslipidaemia, hypertension, ischemic heart disease, chronic kidney disease, and sinusitis further increased the risk of PANDO.Conclusions: GERD increases the risk of PANDO, particularly in females, older adults, and patients with cardiovascular comorbidities or sinusitis. Clinicians should educate GERD patients about the potential risk of PANDO and arrange referrals when necessary.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0