Eye最新文献

{"title":"Prediction of vulnerability to mental health symptoms in children with congenital ectopia lentis: development and validation of a prediction model.","authors":"Xiaolin Liang, Xinyu Zhang, Siyuan Liu, Ling Jin, Charlotte Aimee Young, Yiyuan Ma, Ming Zhou, Danying Zheng, Guangming Jin","doi":"10.1038/s41433-025-03877-0","DOIUrl":"https://doi.org/10.1038/s41433-025-03877-0","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate mental health among children with congenital ectopia lentis (CEL) and to develop an effective nomogram for predicting risk of mental health symptoms in CEL.</p><p><strong>Methods: </strong>In total, 48 children with CEL and 50 control subjects aged 7-18 years old were enrolled in this study. Participants were required to complete the Children's Depression Inventory (CDI) and the Screen for Child Anxiety Related Emotional Disorders (SCARED) questionnaire to screen depressive and anxiety symptoms. Three potential predictors were tested and chosen to build a prediction model using logistic regression.</p><p><strong>Results: </strong>Compared with normal controls, CDI and SCARED scores were higher among children with CEL (P < 0.05). 35.4% of CEL children had varying degrees of depressive or anxiety symptoms. Child's age (odds ratio [OR] = 1.815, 95% confidence interval [CI], 1.084-3.039), duration of disease (OR = 1.557, 95% CI, 1.009-2.403), and systemic abnormalities (OR = 19.894, 95% CI, 1.660-238.463) were identified as predictors of anxiety symptoms. The combination of the above predictors shows good predictive ability, as indicated by area under the curve of 0.924 (95% CI, 0.845-1.000). The calibration curves showed good agreement between the prediction of the nomogram and the actual observations. Additionally, decision curve analysis showed that the nomogram was clinically useful and had better discriminatory power in identifying patients with significant anxiety symptoms.</p><p><strong>Conclusions: </strong>Children with CEL experience higher level of depressive and anxiety symptoms. Child's age, duration of disease and systemic abnormalities are associated factors and can serve as useful indexes in predicting mental illness among CEL children.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and risk factors of pre-senile lens opacities in the 1969-73 Vellore Birth Cohort.","authors":"Padma Paul, Belavendra Antonisamy, Neena John, Andrew Braganza, Thomas Kuriakose, Rita Isaac, Lekha Abraham, Anika Amritanand, Prasanna Samuel, Hepsy Y Chelliah, Mahasampath Gowri S, Nancy Magdalene, Jophy Philips Cherry, Thomas V Paul, Felix Jebasingh, Geetanjali Arulappan, Nihal Thomas, Senthil K Vasan, G V S Murthy, Clare Gilbert","doi":"10.1038/s41433-025-03836-9","DOIUrl":"https://doi.org/10.1038/s41433-025-03836-9","url":null,"abstract":"<p><strong>Purpose: </strong>To estimate the prevalence and determine predictors of lens opacities (LO) among South Asian Indians aged 41-44 years.</p><p><strong>Methods: </strong>This cross-sectional study included 1080 participants from the Vellore Birth Cohort, Vellore, South India. All underwent anthropometric measurements, detailed ophthalmic examination including assessment of LO by LOCS III classification and biochemical metabolic measurements. 'Any cataract' was defined as any opacity type with a score of >2 or evidence of cataract surgery in either eye. Data collected included information on ocular history, life-style factors, socio-economic and educational status, cooking fuel and sunlight exposure. Multivariable logistic regression analysis was used to examine the association between risk predictors and LO.</p><p><strong>Results: </strong>The mean age (SD) of participants was 41.8 (1.0) years; 53.8% were male and 50% were rural residents. The overall prevalence of 'any cataract' was 13.8% (148/1075, 95% confidence interval (CI) 11.8,16.0). The types of cataract were nuclear 59.1%, cortical 16.9%, posterior subcapsular 4.1%, mixed cataracts 18.9% and pseudophakia 0.7%. Increased risk for LO was observed with a history of asthma (OR 4.51; 95% CI 2.1, 9.7), HbA1C of ≥6.5% (OR 2.29; 95% CI 1.4, 3.7), hypertension (OR 1.73; 95% CI 1.1, 2.7) and, in a subgroup (n = 372), lower 25(OH) vitamin D levels (≤20 ng/dL)(OR 5.56; 95% CI 2.3, 13.2).</p><p><strong>Conclusion: </strong>The high prevalence of LO at a relatively young age in South Asian Indians suggests earlier onset of ageing. History of asthma, higher HbA1C, hypertension and lower 25(OH) vitamin D levels were associated with LO.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The acceptance of ophthalmic artificial intelligence for eye diseases: a literature review and qualitative analysis.","authors":"An Ran Ran, Chun Ho Lui, Yih-Chung Tham, Ching-Yu Cheng, Chiu Yu Lam, Wai Lam Cheung, Siu Ting Chan, Hok Ngai Ma, Raphael Walter L C Chow, Dawei Yang, Ziqi Tang, T Y Alvin Liu, Clement C Tham, Carol Y Cheung","doi":"10.1038/s41433-025-03878-z","DOIUrl":"https://doi.org/10.1038/s41433-025-03878-z","url":null,"abstract":"<p><p>Thorough investigations of end-users' awareness, acceptance, and concerns about ophthalmic artificial intelligence (AI) are essential to ensure its successful implementation. We conducted a literature review on the acceptance of ophthalmic AI to provide an overall insight and qualitatively analysed the quality of eligible studies using a psychological model. We identified sixteen studies and evaluated these studies based on four primary factors (i.e., performance expectancy, effort expectancy, social influence, and facilitating conditions) and four regulating factors (i.e., gender, age, experiences, and voluntariness of use) of the psychological model. We found that most of the eligible studies only emphasized performance expectancy and effort expectancy, and in-depth discussions on the effects of social influence, facilitating conditions, and relevant regulating factors were relatively inadequate. The overall acceptance of ophthalmic AI among specific groups, such as patients with different eye diseases, experts in ophthalmology, professionals in other fields, and the general population, is high. Nevertheless, more well-designed qualitative studies with clear definitions of acceptance and using proper psychological models with larger sample sizes involving other representative and multidisciplinary stakeholders worldwide are still warranted. In addition, because of the multifarious concerns of AI, such as the economic burden, patient privacy, model safety, model trustworthiness, public awareness, and proper regulations over accountability issues, it is imperative to focus on evidence-based medicine, conduct high-quality randomized controlled trials, and promote patient education. Comprehensive clinician training, privacy-preserving technologies, and the issue of cost-effectiveness are also indispensable to address the above concerns and further propel the overall acceptance of ophthalmic AI.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro flow properties of Preserflo Michroshunt with an intraluminal stent.","authors":"Enrico Lupardi, Antonio Cassiano, Antonio Moramarco, Luigi Fontana, Ivan Corazza, Keith Barton","doi":"10.1038/s41433-025-03870-7","DOIUrl":"https://doi.org/10.1038/s41433-025-03870-7","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the impact of varying stent sizes and materials on the outflow of the Preserflo Microshunt (PMS).</p><p><strong>Methods: </strong>In vitro experiments were conducted using five new PMS samples. Intraluminal stents of two materials (nylon and polypropylene) and two sizes (9-0 and 10-0) were tested. Flow was measured using a balanced saline solution (BSS) under a constant hydrostatic pressure, and the resistance was calculated. Theoretical calculations based on the Hagen-Poiseuille law were compared with in vitro results, and the results were corrected to calculate resistance to flow using aqueous humour properties. Five measurements were obtained for each material and size.</p><p><strong>Results: </strong>Without any stent, the median resistance internal to PMS corrected for aqueous humour viscosity was 1.59 mmHg/µL/min. Median resistances were 6.35 mmHg/µL/min (range: 3.88-7.42) for the 10-0 nylon and, 11.79 mmHg/µL/min (range: 7.08-13.71) for the 10-0 polypropylene. The 9-0 stents showed higher resistance: 10.99 mmHg/µL/min (range: 7.34-22.75) for 9-0 nylon, finally, the 9-0 polypropylene resulted in a resistance of 37.55 mmHg/µL/min (range: 36.52-38.41).</p><p><strong>Conclusions: </strong>This study indicates that the tested suture materials and sizes have a significant impact on the outflow resistance of the PMS device. Larger sutures and/or polypropylene materials seem to offer more resistance to aqueous outflow.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to 'Comment on: 'Comparing safety and efficacy of Bevacizumab, Ranibizumab and Ranibizumab biosimilar in Retinopathy of prematurity\".","authors":"Puja Maitra, Parag K Shah","doi":"10.1038/s41433-025-03876-1","DOIUrl":"https://doi.org/10.1038/s41433-025-03876-1","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure-function correlates in anterior visual pathway lesions: a systematic review.","authors":"Saif Aldeen Alryalat, Janet L Fan, Henry C Skrehot, Paulina Truong, Meghan Hunt, Ayman Musleh, Osama Al-Deyabat, Lna Malkawi, Deidra St Peter, Cara Capitena Young, Leonard K Seibold, Malik Y Kahook, Andrew G Lee","doi":"10.1038/s41433-025-03868-1","DOIUrl":"https://doi.org/10.1038/s41433-025-03868-1","url":null,"abstract":"<p><p>Visual field defects allow for the localisation of pathologic aetiologies along the entire visual system. However, various aetiologies and location of damage might lead to field defect at similar areas. We reviewed the literature systematically for cases of optic neuropathy with well-defined lesions along the anterior visual pathway from the retina to the lateral geniculate with the goal of correlating specific visual field manifestations with the underlying pathology at each segment. We searched MEDLINE, Scopus, Cochrane CENTRAL, and Web of Science databases on June 9, 2024. We included studies reporting damage at any segment of the anterior visual pathway with corresponding VF outcomes. Studies without primary data or new analyses were excluded. We also provided detailed figures from our own practice of cases with specific anterior visual pathway lesions at different locations and their respective visual field manifestations. Pathologies affecting the retinal ganglion cells and optic disc showed strong correlations with specific visual field defects such as arcuate or altitudinal patterns, and exhibited characteristic structural changes. More posterior lesions commonly produced visual field defects related to crossing fibres. These lesions were also associated with distinctive structural indicators. We emphasise the clinical importance of recognising both anterograde (from the retina) and retrograde (from the lateral geniculate body) axonal degeneration in the development of secondary optic atrophy. This review represents a guide for physicians in their assessment when evaluating visual field defects secondary to optic neuropathy.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptom-based stratification of heterogeneous symptoms of dry eye disease in patients with Sjögren's syndrome.","authors":"Momona Tamagawa, Ken Nagino, Jaemyoung Sung, Akie Midorikawa-Inomata, Atsuko Eguchi, Yuki Morooka, Tianxiang Huang, Shintaro Nakao, Takenori Inomata","doi":"10.1038/s41433-025-03880-5","DOIUrl":"https://doi.org/10.1038/s41433-025-03880-5","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to use symptom-based stratification to identify the subtype-specific pathophysiology of dry eye disease (DED) in Sjögren's syndrome (SS).</p><p><strong>Methods: </strong>We retrospectively enrolled patients with SS who visited Juntendo University Hospital between October 2017 and July 2023 and were diagnosed with DED (2016 Asia Dry Eye Society guideline). The DED subtype and pathophysiology were classified under five distinct tear film breakup patterns: area, line, spot, dimple, and random breaks. Based on responses to the Japanese version of the Ocular Surface Disease Index (J-OSDI), spectral clustering was used to stratify participants; inter-cluster comparison of J-OSDI total scores and key DED-related objective findings was undertaken.</p><p><strong>Results: </strong>Among the 239 participants, DED prevalence was the highest in Cluster 3 (98.2%), followed by clusters 2 (83.4%) and 1 (4.1%). J-OSDI total scores were the highest in Cluster 3 (64.6 points) and lowest in Cluster 1 (2.1 points) (P < 0.001). Prevalence of line and area breaks (aqueous-deficient type) was highest in Cluster 1 (81.6%) whereas dimple and spot breaks (decreased-wettability type) were most prevalent in Cluster 2 (21.0%). Random breaks (increased evaporation) were observed most frequently in Cluster 1 (8.2%). Median MBI was shortest in Cluster 3 (7.1 s), followed by Cluster 2 (8.6 s) (P = 0.003). The median serum anti-SS-A/Ro concentration was highest in Cluster 3 (32.0 U/mL; P = 0.018). Cluster 2 showed a notable discrepancy between subjective symptoms and CFS scores.</p><p><strong>Conclusions: </strong>Using symptom-based DED severity of SS, we successfully stratified patients into three clusters to potentially facilitate type-customised interventions to improve treatment efficacy.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selected Abstracts from The Royal College of Ophthalmologists Annual Congress 2025 ACC, Liverpool, UK.","authors":"","doi":"10.1038/s41433-025-03831-0","DOIUrl":"https://doi.org/10.1038/s41433-025-03831-0","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pathway-driven approach to high-volume digital medical retina clinics.","authors":"Bahar Demir, LingZhi Heng","doi":"10.1038/s41433-025-03873-4","DOIUrl":"https://doi.org/10.1038/s41433-025-03873-4","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brolucizumab clinical and safety outcomes in a neovascular age-related macular degeneration national database: Fight Retinal Blindness Spain (FRB Spain).","authors":"Javier Zarranz-Ventura, Sonia Marías-Pérez, Ruben Martin-Pinardel, Manel Fernandez-Bonet, Begoña Pina-Marin, Estefanía Cobos, Carmen Antía Rodríguez-Fernandez, Alba Parrado-Carrillo, Isaac Alarcón-Valero, Carles Barnes, Esther Cilveti, Julia Aramburu-Claveria, Francisco J Ascaso-Puyuelo, Pilar Calvo, Maria Pilar Ruiz-Del-Tiempo, Gabriela Susanna-González, Marc Figueras-Roca, Ricardo P Casaroli-Marano, Carolina Bernal-Morales","doi":"10.1038/s41433-025-03871-6","DOIUrl":"https://doi.org/10.1038/s41433-025-03871-6","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate clinical outcomes, treatment intervals, and safety outcomes of brolucizumab (BRO) treatment in a national neovascular age-related macular degeneration (nAMD) database.</p><p><strong>Methods: </strong>Multicentre, national, routine clinical care database study of nAMD eyes receiving ≥1 BRO injection. Demographics, visual acuity (VA) measured in logMAR letters, macular neovascularization (MNV) activity, number of injections, visit data and information on any adverse events were collected at baseline and at 3, 6, 9 and 12 months after BRO initiation for each patient/eye.</p><p><strong>Results: </strong>A total of 305 eyes received <math><mo>≥</mo></math> 1 BRO injection and 214 eyes (14% naïve, 86% switchers) completed <math><mo>≥</mo></math> 3 months follow-up. In switchers, the percentage of eyes extended to ≥8 week intervals at 3/6/9 months was 43.2%/45.7%/54.5% and to ≥10 week intervals was 12.9%/18.5%/13.6%, respectively. Eyes with VA ≥ 70 increased from 36% at baseline to 48% at 3 months and 50% at 9 months. MNV lesion activity status decreased from 94% (active/active-only SRF, 46/48%) at baseline to 56% (21/35%), 61% (23/38%), 76% (27/49%) and 65% (24/41%) at months 3/6/9 and 12, respectively. Adverse effects were observed in 6.5% of the treated eyes, being the most prevalent anterior uveitis (3.2%), vitritis (4.5%) and vasculitis (2.2%).</p><p><strong>Conclusion: </strong>In this series BRO achieves an extension in the treatment intervals in half of the patients which require frequent reinjections (<8 weekly), reducing MNV activity in a third of this specific difficult-to-treat subgroup. The adverse event rates described are consistent with other cohorts and need to be considered to inform treatment decisions in case-by-case discussions.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}