Eye最新文献

{"title":"Unequal Access and Evolving Priorities in U.S. Uveitis Clinical Trials: A 23-year Analysis of Regional, Institutional, and Anatomic trends.","authors":"Jainam Shah, Sachin Pathuri, Carl S Wilkins, Andrew D Parsons, Ibrahim Furkan Acar, Elanit Safaei, Sailesh V Tummala","doi":"10.1038/s41433-025-03854-7","DOIUrl":"https://doi.org/10.1038/s41433-025-03854-7","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review of clinical practice guidelines for the management of neovascular age-related macular degeneration.","authors":"Jennifer I Lim, Stella Ko, Mark McAllister, Nancy Faux, Komal Bawa, Elizabeth Mearns, Shriji Patel, Galin Spicer, Amanda Martinez, David Tabano","doi":"10.1038/s41433-025-03829-8","DOIUrl":"https://doi.org/10.1038/s41433-025-03829-8","url":null,"abstract":"<p><strong>Background/objectives: </strong>To assess geographically global clinical practice guidelines (CPGs) for neovascular age-related macular degeneration (nAMD) management.</p><p><strong>Methods: </strong>A systematic literature review (SLR) of CPGs for nAMD management was conducted using Embase and MEDLINE databases, Guideline Central, Health Technology Assessment bodies, professional ophthalmology associations, and backwards citation tracking. CPGs published between January 2010-October 2023 were included and independently assessed by four reviewers using the Appraisal of Guidelines for Research and Evaluation II (AGREE II). CPGs were qualitatively assessed for anatomical measurements (optical coherence tomography [OCT] and visual acuity [VA]). PROSPERO identification is CRD42023473223.</p><p><strong>Results: </strong>Nine of 147 identified global CPGs were included in the SLR for diagnosis, treatment, and disease monitoring for nAMD. Overall AGREE II scores were 62-95 (mean [standard deviation] score 75 [10.6]). Strongest domains were Scope and Purpose (86.6 [11.0]), Clarity of Presentation (84.3 [13.0]), and Editorial Independence (89.1 [15.4]); Stakeholder Involvement (63.4 [16.6]), Applicability (73.0 [12.6]), and Rigor of Development (55.4 [25.9]) were lowest. 4/9 CPGs were \"Recommended\" by reviewers, and 5/9 were \"Recommended with Modifications\". All CPGs recommended OCT for initial diagnosis. 2/9 CPGs did not mention VA. For managing pharmacological interventions, 4/9 CPGs recommended using VA, and three recommended OCT. Eight CPGs recommended using either VA or OCT for disease monitoring while on anti-vascular endothelial growth factor (VEGF) treatment. 6/9 CPGs recommended screening for VA and 7/9 CPGs recommended using OCT to change anti-VEGF intervals.</p><p><strong>Conclusion: </strong>CPG methods, recommendations on applicability in resource-constrained systems, and patient advocacy/perspectives will improve CPG trustworthiness and transparency.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of selection criteria for ophthalmology training in the Western world.","authors":"Thomas Muecke, Carson Petrash, Goran Petrovski, Stephen Bacchi, Robert Casson, Weng Onn Chan","doi":"10.1038/s41433-025-03850-x","DOIUrl":"https://doi.org/10.1038/s41433-025-03850-x","url":null,"abstract":"<p><strong>Background: </strong>To (a) analyse, compare and learn from the global variations in ophthalmology training applicant selection criteria, specifically CV assessment, and (b) provide a discussion of evidence supporting such selection criteria.</p><p><strong>Methods: </strong>An observational analysis on the selection criteria used to assess candidates applying to ophthalmology training programs within the US, Canada, European Union / European Economic Union (EU/EEA), United Kingdom (UK) and Australia and New Zealand (ANZ). Presence of a publicly available selection criteria policy for the 2025 intake was searched for on national and local college, society, federation and training program websites. The selection criteria employed for assessing applicant CV, and its associated scoring (if existent), were recorded for the included programs. Descriptive statistics was applied to these data.</p><p><strong>Results: </strong>174 accredited ophthalmology training programs were identified, and 51/174 publish a publicly available selection criteria policy. Overall, the most important criteria from ophthalmic training bodies in the Western world include research experience, academic achievements, particularly in the form of awards and prizes, references supporting evidence of favourable personal and professional characteristics, and evidence of involvement in extracurricular activities that produce evidence of a well-founded interest in ophthalmology.</p><p><strong>Conclusions: </strong>Each region adopts varying selection processes and frameworks, which, rather than reflect a standardised international approach to selecting an \"ideal\" ophthalmology trainee, perhaps select for the specific needs of the country and or training program. The study is limited by its observational nature.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of retino-choroidal thickness and vascular metrics with drusen volume as a severity marker of age-related macular degeneration.","authors":"Elham Sadeghi, Anne Schulman, Sharat Chandra Vupparaboina, Sumit Randhir Singh, Nasiq Hasan, Sandeep Chandra Bollepalli, Kiran Kumar Vupparaboina, Jose Alain Sahel, Andrew W Eller, Jay Chhablani","doi":"10.1038/s41433-025-03847-6","DOIUrl":"https://doi.org/10.1038/s41433-025-03847-6","url":null,"abstract":"<p><strong>Purpose: </strong>To assess retinal vascular perfusion and choroidal vascularity biomarkers correlated with drusen volume and severity of age-related macular degeneration (AMD).</p><p><strong>Methods: </strong>Patients underwent swept-source optical coherence tomography angiography (SS-OCTA) (PlexElite-9000). Eyes with geographic atrophy or neovascular AMD were excluded. Retinal thickness, retinal perfusion including superficial (SCP) and deep capillary plexuses (DCP), foveal avascular zone (FAZ), drusen volume, choroidal thickness (ChT) and choroidal vascularity index (CVI) were assessed through the Advanced Research and Innovation Network. Linear mixed model and Spearman test were used for statistical analysis.</p><p><strong>Results: </strong>We assessed 81 eyes from 57 subjects (34 early-stage, 47 intermediate-stage AMD). The mean age was 74.95 ± 8.79 years. The mean LogMar visual acuity (VA) was 0.16 ± 0.18 (early-stage: 0.12 ± 0.17, intermediate-stage: 0.19 ± 0.18, P = 0.122). Between early and intermediate AMD, no significant differences were seen in SCP and DCP vascular perfusion (P = 0.368, 0.859, respectively), FAZ (p = 0.836) and retinal thickness within the 6-mm area (P = 0.680). Drusen volume showed a significant difference (early-stage: 0.0706 ± 0.1272, intermediate-stage: 0.2102 ± 0.2211mm³, P < 0.01). Intermediate-stage AMD had significantly lower mean ChT (266.40 ± 115.55 vs. 204.97 ± 70.69 µm, P = 0.038) and CVI (0.605 ± 0.021 vs. 0.591 ± 0.015, P = 0.004) within the 5-mm area. Drusen volume was negatively correlated with ChT (r = -0.198, P = 0.017) and CVI (r = -0.209, P = 0.029). No significant correlation was found between drusen volume and VA (r = 0.051, P = 0.143), retinal thickness (-0.03, P = 0.393), FAZ (r = -0.023, P = 0.150), SCP (r = -0.011, P = 0.307), and DCP (r = -0.022, P = 0.190).</p><p><strong>Conclusion: </strong>Drusen volume, a key AMD severity marker, correlates more strongly with choroidal parameters like ChT and CVI than retinal thickness and perfusion. It may serve as a biomarker for dry AMD severity, with choroidal biomarkers showing earlier disease changes.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal optical coherence tomography angiography (OCTA) biomarkers of cardiovascular disease: a review article.","authors":"Simon D Archambault, Omar Abu-Qamar, David Biery, Antonio Yaghy, Brittany Weber, Nadia K Waheed","doi":"10.1038/s41433-025-03780-8","DOIUrl":"https://doi.org/10.1038/s41433-025-03780-8","url":null,"abstract":"<p><p>This review article systematically assesses existing literature on studies employing retinal optical coherence tomography angiography (OCTA) metrics as surrogate biomarkers for cardiovascular disease. A comprehensive, literature review of published peer-reviewed research was conducted within PubMed utilizing the following medical subject headings (MeSH) terms: \"optical coherence tomography\", \"cardiovascular diseases\", \"retina\", and \"retinal vessels\". A total of 840 articles were reviewed and selectively filtered with ultimately 50 articles being included. This review article elucidates key findings, identifies limitations, and pinpoints gaps within these investigations. Additionally, this article delineates constraints related to OCTA technology and image processing that presently hinder the widespread adoption of this promising technology.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optic disc morphology in congenital glaucoma.","authors":"Arnav Panigrahi, Nikhil Sawant, Manzoor Ahmad Malik, Shikha Gupta, Anurag Kumar, Swati Phuljhele, Parul Sony, Viney Gupta","doi":"10.1038/s41433-025-03839-6","DOIUrl":"https://doi.org/10.1038/s41433-025-03839-6","url":null,"abstract":"<p><strong>Objectives: </strong>This cross sectional study aimed to evaluate the optic disc morphology with respect to the optic disc size, tilt and torsion in eyes of children with congenital glaucoma.</p><p><strong>Methods: </strong>Children with congenital glaucoma (controlled with therapy), including primary congenital glaucoma (PCG) and those with Axenfeld-Rieger Malformation (ARM) who were now cooperative for fundus photography and scanning laser ophthalmoscopy, were recruited. Controls were age and gender matched children, who were following up at our institute for refractive error or had undergone strabismus surgery before the age of 3 years and were now old enough to cooperate for a fundus photography. Fundus photographs were evaluated using Image J processing software to obtain optic disc tilt and torsion. Axial length (AL) and optic disc area (DA) were correlated with the disc tilt and torsion. The axial length, optic disc area, optic disc tilt, optic disc torsion were compared between affected eyes with PCG with those of healthy controls and the unaffected eyes of unilateral PCG as well as between PCG and those with ARM.</p><p><strong>Results: </strong>Affected eyes of children with PCG (n = 109) had a DA (2.3 ± 0.7 mm² vs. 2.1 ± 0.5 mm²), disc tilt (1.1 ± 0.1 vs. 1.1 ± 0.2) and disc torsion (median 10 vs. 6 degree) not significantly different (p = 0.8, p = 1, p = 0.61 respectively) from eyes of healthy children (n = 96). Mean AL in PCG eyes was significantly greater (p < 0.028) than in healthy control eyes and correlated with the DA in PCG eyes (Pearson correlation=0.32, p = 0.014). Affected eyes of children with unilateral congenital glaucoma (n = 33) had a DA (2.3 ± 0.54 mm² vs. 2.1 ± 0.54 mm²), disc tilt (1.1 ± 0.09 vs. 1.1 ± 0.1) and disc torsion (median 10 vs. 10 degree) not significantly different (p = 0.64, p = 0.1, p = 0.75 respectively) from the unaffected eyes. However, eyes of patients with ARM had higher disc torsion compared to controls (p = 0.043).</p><p><strong>Conclusion: </strong>Despite axial elongation, the optic disc morphology of children with primary congenital glaucoma are not significantly different from healthy controls.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo analysis of iridocorneal angle parameters with spectral-domain optical coherence tomography in children with Neurofibromatosis type 1.","authors":"Murat Gunay, Ibrahim Mert Kurt, Ugur Yilmaz, Adem Turk, Dilek Uzlu, Busra Kose, Pinar Ozkan Kart, Ali Cansu","doi":"10.1038/s41433-025-03840-z","DOIUrl":"https://doi.org/10.1038/s41433-025-03840-z","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate iridocorneal angle (ICA) parameter measurements with spectral-domain optical coherence tomography (SD-OCT) in children with Neurofibromatosis type 1 (NF1) and to compare them with those in healthy children.</p><p><strong>Methods: </strong>Twenty children with NF1 and 33 age- and sex-matched healthy controls were enroled. All subjects underwent ICA imaging with SD-OCT. Schlemm canal diameter (SCD), anterior chamber angle (ACA), angle opening distance (AOD500 and AOD750), trabecular-iris space area (TISA500 and TISA750) and scleral spur length (SSL) were examined in the temporal sections and measured with customized software. Also, iris thickness (IT) was measured as the distances between the anterior and posterior iris surface, at 1 mm (IT-1), 2 mm (IT-2) and 3 mm (IT-3) from the edge of the pupil.</p><p><strong>Results: </strong>Mean ACD was significantly narrower in NF1 group (p = 0.003). Mean levels of SCD (p < 0.001), ACA (p = 0.001), AOD500 (p = 0.001), AOD750 (p < 0.001), TISA500 (p < 0.001) and TISA750 (p < 0.001) were significantly lower in NF1 group. Mean SSL-1 (p = 0.19) and SSL-2 (p = 0.56) measurements were found to be similar between the groups. Mean IT-1 (p < 0.001), IT-2 (p < 0.001) and IT-3 (0.03) were observed to be significantly higher in NF1 group. There was significant correlation between ACD and IT. Also, ACD and IT showed significant associations with the ICA parameters.</p><p><strong>Conclusion: </strong>There was a significantly narrower ICA morphology in NF1 children. SCD was significantly decreased in children with NF1. A significantly thicker iris in NF1 children may offer a possible impact of iris morphology on narrower ICA parameters and SCD.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hybrid closed loop devices: The utility of continuous glucose monitoring metrics for retinal surveillance during transition from standard insulin pump.","authors":"Maria S Varughese, Ananth U Nayak, Louise Payne, Lakshminarayanan Varadhan","doi":"10.1038/s41433-025-03834-x","DOIUrl":"https://doi.org/10.1038/s41433-025-03834-x","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal relationships between depression, anxiety, and myopia: a two-sample Mendelian randomization study.","authors":"Shengsong Xu, Xiao Wang, Jinyi Xu, Xianghua Tang, Wenlong Hao, Chuqi Xiang, Xingyu Lei, Mengyi Wang, Xiao Yang","doi":"10.1038/s41433-025-03841-y","DOIUrl":"10.1038/s41433-025-03841-y","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the causal relationship between depression, anxiety, and myopia.</p><p><strong>Methods: </strong>The multivariable Mendelian randomization (MR) design using summary statistics from independent genome-wide association studies (GWAS) was employed. The anxiety and depression, were used as exposures, and myopia was used as the outcome. Genetic variants associated with depression were derived using GWAS summary statistics from the FinnGen consortium database. Genetic variants associated with anxiety were derived from the Psychiatric Genomics consortium. The inverse-variance-weighted method was the main applied analytic tool and was complemented with comprehensive sensitivity analyses.</p><p><strong>Results: </strong>A total of 21, 10 SNPs were selected as instrumental variables for depression and anxiety, respectively. Based on the IVW analysis, both depression (OR = 1.010, 95% CI = 1.002-1.018, P = 0.016) and anxiety (OR = 1.083, 95%CI = 1.022-1.149, P = 0.008) increased the risk of myopia. After adjusting in the multivariable MR, the IVW and Egger methods indicated that depression (OR = 1.004, 95%CI = 1.000-1.008, P = 0.030) or anxiety (OR = 1.004, 95%CI = 1.001-1.008, P = 0.026) was still associated with elevated risks of myopia.</p><p><strong>Conclusions: </strong>The current study identified a causal relationship between anxiety, depression, and an increased risk of myopia. These observations suggest that when developing strategies to control myopia, it is also important to focus on the mental health of children. Further detailed research is needed to fully understand this issue.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steatocystoma of the Eyelid.","authors":"Bipasha Mukherjee","doi":"10.1038/s41433-025-03820-3","DOIUrl":"https://doi.org/10.1038/s41433-025-03820-3","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}