Eye最新文献 - Book学术

"Comparative analysis of large language models against the NHS 111 online triaging for emergency ophthalmology". “大型语言模型与NHS 111在线眼科急诊分诊的比较分析”。

IF 2.8 3区医学

Eye Pub Date : 2025-01-21 DOI: 10.1038/s41433-025-03605-8

Shaheryar Ahmed Khan, Chrishan Gunasekera

{"title":"\"Comparative analysis of large language models against the NHS 111 online triaging for emergency ophthalmology\".","authors":"Shaheryar Ahmed Khan, Chrishan Gunasekera","doi":"10.1038/s41433-025-03605-8","DOIUrl":"https://doi.org/10.1038/s41433-025-03605-8","url":null,"abstract":"Background: This study presents a comprehensive evaluation of the performance of various large language models in generating responses for ophthalmology emergencies and compares their accuracy with the established United Kingdom's National Health Service 111 online system.Methods: We included 21 ophthalmology-related emergency scenario questions from the NHS 111 triaging algorithm. These questions were based on four different ophthalmology emergency themes as laid out in the NHS 111 algorithm. Responses generated from NHS 111 online, were compared to different LLM-chatbots responses to determine the accuracy of LLM responses. We included a range of models including ChatGPT-3.5, Google Bard, Bing Chat, and ChatGPT-4.0. The accuracy of each LLM-chatbot response was compared against the NHS 111 Triage using a two-prompt strategy. Answers were graded as following: -2 graded as \"Very poor\", -1 as \"Poor\", O as \"No response\", 1 as \"Good\", 2 as \"Very good\" and 3 graded as \"Excellent\".Results: Overall LLMs' attained a good accuracy in this study compared against the NHS 111 responses. The score of ≥1 graded as \"Good\" was achieved by 93% responses of all LLMs. This refers to at least part of this answer having correct information as well as absence of any wrong information. There was no marked difference and very similar results seen overall on both prompts.Conclusions: The high accuracy and safety observed in LLM responses support their potential as effective tools for providing timely information and guidance to patients. LLMs hold promise in enhancing patient care and healthcare accessibility in digital age.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 57-year-old female with retinoblastoma. 57岁女性视网膜母细胞瘤。

IF 2.8 3区医学

Eye Pub Date : 2025-01-20 DOI: 10.1038/s41433-025-03617-4

Zhihui Xu, Huijing Ye, Huasheng Yang

引用次数: 0

Multi-cohort analysis identifying core ocular surface microbiome and bacterial alterations in eye diseases. 多队列分析鉴定眼病中核心眼表微生物组和细菌的改变。

IF 2.8 3区医学

Eye Pub Date : 2025-01-20 DOI: 10.1038/s41433-024-03589-x

Xiangtian Ling, Xiu Juan Zhang, Christine H T Bui, Hei Nga Chan, Jennifer Wing Ki Yau, Fang Yao Tang, Ka Wai Kam, Patrick Ip, Alvin L Young, Kam Lun Hon, Clement C Tham, Chi Pui Pang, Li Jia Chen, Jason C Yam

{"title":"Multi-cohort analysis identifying core ocular surface microbiome and bacterial alterations in eye diseases.","authors":"Xiangtian Ling, Xiu Juan Zhang, Christine H T Bui, Hei Nga Chan, Jennifer Wing Ki Yau, Fang Yao Tang, Ka Wai Kam, Patrick Ip, Alvin L Young, Kam Lun Hon, Clement C Tham, Chi Pui Pang, Li Jia Chen, Jason C Yam","doi":"10.1038/s41433-024-03589-x","DOIUrl":"https://doi.org/10.1038/s41433-024-03589-x","url":null,"abstract":"Purpose: Inconsistency exists among reported studies on the composition of human ocular surface microbiome (OSM). The roles of OSM in ocular diseases remain uncertain. In this study, we aimed to determine the composition of OSM and to evaluate its potential roles and functions from multiple cohorts.Methods: Raw 16 s sequencing data were obtainable from publicly available repositories, sourced from 17 published studies. Employing a standardized method, we processed the data and conducted a cross-cohort analysis. Through bioinformatics pipelines QIIME2 and PICRUSt2, we processed a total of 1875 ocular surface samples. Core microbiome analyses, genera comparisons, and MetaCyc pathway analyses were performed within each cohort independently. The results were then combined to identify shared patterns across different datasets.Results: The core OSM comprised seven genera: Corynebacterium, Staphylococcus, Acinetobacter, Streptococcus, Pseudomonas, Cutibacterium and Bacillus. Corynebacterium and Staphylococcus are the most abundant genera on ocular surface. Most ocular diseases showed OSM alterations and eight genera demonstrated a non-specific, shared response among two or more ocular diseases. Moreover, changes in various metabolic pathways were predicted following OSM alteration, indicating potential roles of OSM in biological processes.Conclusion: We refined the core OSM candidates combining multiple cohorts. The common pattern shared by different cohorts is worth further investigation. Changes in metabolic pathways based on bioinformatic analysis indicated a role of OSM on ocular diseases. Our results help extend the knowledge and encourage further investigations on the associations between OSM and ocular diseases.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitreomacular traction - a review. 玻璃体黄斑牵引-回顾。

IF 2.8 3区医学

Eye Pub Date : 2025-01-20 DOI: 10.1038/s41433-024-03576-2

Manasi Ketkar, Vivek Pravin Dave, Francesc March de Ribot, Ahmed B Sallam, Manoj P Shettigar, Yi-Ting Hsieh, Tso-Ting Lai, Soefiandi Soedarman, Laura Liu, Lihteh Wu, Lars-Olaf Hattenbach, Avinash Pathengay, Rajeev Reddy Pappuru

引用次数: 0

Cochrane corner: artificial intelligence for diagnosing exudative age-related macular degeneration. 人工智能诊断渗出性老年性黄斑变性。

IF 2.8 3区医学

Eye Pub Date : 2025-01-20 DOI: 10.1038/s41433-025-03599-3

Ariel Yuhan Ong, Henry David Jeffry Hogg, Pearse A Keane

引用次数: 0

Features of intermediate and late dry age-related macular degeneration on adaptive optics ophthalmoscopy: Pinnacle Study Report 8. 中晚期干性老年性黄斑变性在自适应光学眼底检查中的特征：Pinnacle研究报告8。

IF 2.8 3区医学

Eye Pub Date : 2025-01-20 DOI: 10.1038/s41433-025-03607-6

Ahmed M Hagag, Christopher Holmes, Ahmer Raza, Sophie Riedl, Philipp Anders, Rebecca Kaye, Toby Prevost, Lars G Fritsche, Daniel Rueckert, Hrvoje Bogunović, Hendrick P N Scholl, Ursula Schmidt-Erfurth, Andrew J Lotery, Sobha Sivaprasad

{"title":"Features of intermediate and late dry age-related macular degeneration on adaptive optics ophthalmoscopy: Pinnacle Study Report 8.","authors":"Ahmed M Hagag, Christopher Holmes, Ahmer Raza, Sophie Riedl, Philipp Anders, Rebecca Kaye, Toby Prevost, Lars G Fritsche, Daniel Rueckert, Hrvoje Bogunović, Hendrick P N Scholl, Ursula Schmidt-Erfurth, Andrew J Lotery, Sobha Sivaprasad","doi":"10.1038/s41433-025-03607-6","DOIUrl":"https://doi.org/10.1038/s41433-025-03607-6","url":null,"abstract":"Background/objectives: Adaptive optics ophthalmoscopy (AOO) has the potential to provide insights into AMD pathology and to assess the risk of progression. We aim to utilise AOO to describe detailed features of intermediate AMD and to characterise microscopic changes during atrophy development.Subjects/methods: Patients with intermediate AMD were recruited into PINNACLE, a prospective observational cohort study. Participants underwent flood-illumination AOO using the commercially available rtx1 camera. AOO images were qualitatively assessed and correlated with clinical imaging including optical coherence tomography (OCT) and infrared scanning laser ophthalmoscopy.Results: The visibility of cone mosaic was generally compromised in eyes with intermediate AMD. We observed an association between the visibility of cone mosaic on AOO and the detection of a well-defined normal interdigitation zone on OCT. Drusen subtypes were identified on AOO as variations in reflectance at the edge and/or the centre of the druse. The absence of a hyperreflective margin was associated with the loss of the overlying ellipsoid zone on OCT prior to the collapse of the druse. With progressive attenuation of the retinal pigment epithelium and loss of photoreceptor layers, the drusenoid lesion appeared more hyperreflective with very distinctive edges.Conclusions: This cross-sectional study supports the potential value of AOO for providing information on intermediate AMD and the development of atrophic lesions that cannot be seen in conventional imaging modalities. The ongoing longitudinal PINNACLE study is assessing the significance of the described findings.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between preoperative aqueous cytokine levels and mid-term corneal endothelial cell loss following penetrating keratoplasty. 术前水细胞因子水平与穿透性角膜移植术后中期角膜内皮细胞损失的相关性。

IF 2.8 3区医学

Eye Pub Date : 2025-01-20 DOI: 10.1038/s41433-025-03610-x

Hiroshi Matsumae, Kaon Kataoka, Yukari Yagi-Yaguchi, Kazunari Higa, Takanori Suzuki, Hirotsugu Kasamatsu, Jun Shimazaki, Takefumi Yamaguchi

{"title":"Correlation between preoperative aqueous cytokine levels and mid-term corneal endothelial cell loss following penetrating keratoplasty.","authors":"Hiroshi Matsumae, Kaon Kataoka, Yukari Yagi-Yaguchi, Kazunari Higa, Takanori Suzuki, Hirotsugu Kasamatsu, Jun Shimazaki, Takefumi Yamaguchi","doi":"10.1038/s41433-025-03610-x","DOIUrl":"https://doi.org/10.1038/s41433-025-03610-x","url":null,"abstract":"Objective: To investigate the association between preoperative aqueous humour (AqH) cytokines and mid-term endothelial cell density (ECD) following penetrating keratoplasty (PKP).Methods: This study analysed a total of 87 eyes of which 54 underwent PKP and 33 eyes underwent cataract surgery. AqH samples were collected at the beginning of surgery. The levels of cytokines (interleukins [ILs]-1α, -1β, -4, -6, -8, -10, -17A, monocyte chemotactic protein [MCP]-1, interferon [IFN]-α, IFN-γ, E-selectin, P-selectin, and soluble intercellular adhesion molecule-1 [sICAM-1]) in the AqH were measured using a multiplex beads immunoassay. The subjects who underwent PKP were classified into two groups: Group 1: ECD < 1200 cells/mm2 at 36 months and graft failure during follow-up (38 eyes); Group 2 ECD ≥ 1200 cells/mm2 at 36 months (16 eyes).Results: The ECD reduction per year was significantly correlated with the preoperative levels of protein (r = 0.48; P < 0.001), IL-6 (r = 0.29; P = 0.048), IL-8 (r = 0.42; P = 0.003), IL-12p70 (r = 0.46; P = .007), MCP-1 (r = 0.28; P = 0.049), IFN -γ (r = 0.43; P = 0.008), and s-ICAM-1 (r = 0.30; P = 0.03). The preoperative levels of IL-8, and IFN-γ in AqH were significantly higher in eyes with ECD < 1200 cells/mm2 compared to those with ECD ≥ 1200 cells/mm2 at 3 years (P ≤ 0.02).Conclusion: Preoperative AqH cytokine levels are associated with mid-term ECD reduction after PKP. Pathological alterations of the AqH microenvironment may affect mid-term corneal endothelial cell survival.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Noncryopexy versus cryopexy treatment during scleral buckling: a systematic review and meta-analysis. 非冷冻与冷冻治疗在巩膜屈曲：系统回顾和荟萃分析。

IF 2.8 3区医学

Eye Pub Date : 2025-01-20 DOI: 10.1038/s41433-025-03614-7

Kuan-Ying Chen, Yu-Chen Su, Sheng-Min Hsu

{"title":"Noncryopexy versus cryopexy treatment during scleral buckling: a systematic review and meta-analysis.","authors":"Kuan-Ying Chen, Yu-Chen Su, Sheng-Min Hsu","doi":"10.1038/s41433-025-03614-7","DOIUrl":"https://doi.org/10.1038/s41433-025-03614-7","url":null,"abstract":"Objectives: To evaluate the differences in surgical outcomes between scleral buckling (SB) with noncryopexy and cryopexy methods.Methods: We systematically searched the Embase, Medline, Cochrane Library, and Scopus databases for randomized controlled trials (RCTs) published from their inception until January 1, 2024. A random-effects model was applied, and outcomes are presented as risk ratios (RRs) or standardized mean differences with 95% confidence intervals (CIs). The certainty of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation criteria.Results: We included seven RCTs involving a total of 1103 patients. The meta-analysis revealed comparable retinal reattachment rates between noncryopexy and cryopexy methods (RR: 1.00; 95% CI: 0.96-1.05). Our subgroup analysis revealed similar results between nonretinopexy and laser retinopexy subgroups. Moreover, postoperative visual acuity (VA) and complication rates were comparable between noncryopexy and cryopexy methods (proportion of eyes with postoperative VA of 20/40 or better: RR: 1.24, 95% CI: 0.83-1.85; macular pucker: RR: 1.08, 95% CI: 0.53-2.21; cystoid macular oedema: RR: 1.01, 95% CI: 0.79-1.30; and subretinal pigmentary migration: RR: 0.34, 95% CI: 0.08-1.38). However, the certainty of evidence for these outcomes was low to very low, indicating the need for cautious interpretation of these findings.Conclusions: Similar surgical outcomes were noted between noncryopexy and cryopexy methods in SB, suggesting that both methods are effective in repairing rhegmatogenous retinal detachment. However, future studies on a larger scale and with longer follow-ups may be necessary to detect late redetachment and complications.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oestrus ovis larvae on the cornea. 发情的卵在角膜上。

IF 2.8 3区医学

Eye Pub Date : 2025-01-20 DOI: 10.1038/s41433-025-03609-4

Bixia Wei, Lin Ding, Tao Shen

引用次数: 0

Incidence of optic nerve kinking in a cohort of patients with Normal tension glaucoma. 正常张力性青光眼患者视神经扭结的发生率。

IF 2.8 3区医学

Eye Pub Date : 2025-01-18 DOI: 10.1038/s41433-025-03608-5

Achmed Pircher, Jatta Berberat, Luca Remonda, Cynthia J Roberts, Albert Neutzner, Hanspeter E Killer

{"title":"Incidence of optic nerve kinking in a cohort of patients with Normal tension glaucoma.","authors":"Achmed Pircher, Jatta Berberat, Luca Remonda, Cynthia J Roberts, Albert Neutzner, Hanspeter E Killer","doi":"10.1038/s41433-025-03608-5","DOIUrl":"https://doi.org/10.1038/s41433-025-03608-5","url":null,"abstract":"Objectives: To report on the incidence of optic nerve kinking in a series of patients diagnosed with normal-tension glaucoma (NTG) compared to an age- and gender matched control group without known optic nerve diseases.Subjects and methods: All patients with NTG who underwent imaging (computed tomography cysternography (CTC) or magnetic resonance imaging (MRI)) of the orbits and cranium between 2012 and 2022 were included, totalling 57 patients (27 females and 30 males; 57 eyes; mean age 69 ± 10 years). 57 age- and gender matched subjects without known optic nerve diseases who underwent MRI of the orbits and cranium served as controls. Radiographic images of the orbits were analysed for the presence of optic nerve kinking.Results: In the axial plane at least one optic nerve kink was found in 49 of 57 (86%) optic nerves in patients with NTG and in 10 of 57 (18%) optic nerves in controls (p < 0.0001) while in the sagittal plane in 28 of 57 (49%) optic nerves in patients with NTG and in 1 of 57 (2%) optic nerves in controls (p < 0.0001) (Fisher's two-tailed exact test).Conclusions: This study demonstrates a high statistically significant incidence of optic nerve kinking in patients with NTG compared to controls without known optic nerve diseases. Its possible role involved in the pathophysiology of NTG needs to be evaluated.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0