IF 4.4 3区医学

Eye Pub Date : 2026-10-12 DOI: 10.1038/s41433-026-04889-0

Jiabei Xiong, Jiayin Cai, Jian Li

引用次数: 0

Global health training in North American ophthalmology residency programs: a cross-sectional study. 北美眼科住院医师项目的全球健康培训：一项横断面研究。

IF 4.4 3区医学

Eye Pub Date : 2026-10-10 DOI: 10.1038/s41433-026-04951-x

Haaris M Khan, Parsa Khatami, Arvin Zaker, Sophie Sajjadi, Hall Chew, Eduardo V Navajas, Nimesh A Patel, Simon P Holland

引用次数: 0

Pneumatic retinopexy identification in electronic medical records using an on-premises large language model. 使用本地大型语言模型的电子病历气动视网膜固定术识别。

IF 4.4 3区医学

Eye Pub Date : 2026-10-09 DOI: 10.1038/s41433-026-04958-4

James Tsimiklis, Shrirajh Satheakeerthy, Jai Paris, Weng Onn Chan

引用次数: 0

Prelaminar hyperreflective lines in non-arteritic anterior ischaemic optic neuropathy. 非动脉性前缺血性视神经病变的层前高反射线。

IF 4.4 3区医学

Eye Pub Date : 2026-10-09 DOI: 10.1038/s41433-026-04954-8

Anas Alkhabaz, Bianca Chan, Yulan Ren, Rishita Rama Pujari, Jamie Zhang, Hugo Wu, Yaping Joyce Liao

{"title":"Prelaminar hyperreflective lines in non-arteritic anterior ischaemic optic neuropathy.","authors":"Anas Alkhabaz, Bianca Chan, Yulan Ren, Rishita Rama Pujari, Jamie Zhang, Hugo Wu, Yaping Joyce Liao","doi":"10.1038/s41433-026-04954-8","DOIUrl":"https://doi.org/10.1038/s41433-026-04954-8","url":null,"abstract":"Objective: To compare clinical and imaging features of non-arteritic anterior ischaemic optic neuropathy (NAION) with and without optic disc drusen (ODD)-like features, including ODD and hyperreflective lines (HRLs), and assess the impact of HRLs on disease outcomes.Methods: This is a retrospective analysis of 17 NAION patients with ODD (ODD-AION), 25 NAION patients with HRLs only (HRL-AION), and 45 NAION patients without ODD-like features from a dataset of 177 NAION patients. ODD-like features were diagnosed via the enhanced-depth imaging optical coherence tomography (EDI-OCT). Patients underwent full ophthalmic assessment, including visual acuity, Humphrey visual field mean deviation, ganglion cell complex (GCC), retinal nerve fiber layer (RNFL), Bruch's membrane opening (BMO), and flavoprotein fluorescence (FPF) imaging.Results: ODD-like features were present in 23.7% of the NAION cohort and were associated with younger age at NAION onset and better visual acuity (adjusted p = 0.027), with higher GCC and RNFL thickness. BMO was significantly smaller in eyes with ODD-like features. ODD-AION showed earlier onset and female predominance, whereas HRL-AION resembled typical NAION demographically but had more favorable structural and visual outcomes. HRL-AION eyes demonstrated a lower global FPF signal when compared with NAION and ODD-AION.Conclusion: Like ODD, the presence of HRLs in NAION is associated with crowding of the optic nerve head and better structural and functional outcomes, but not with a young onset of the disease. This study highlights the heterogeneity of NAION and the role of EDI-OCT findings in understanding determinants of outcomes.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149148476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Large language models as internal consistency checkers for ophthalmic manuscripts. 大型语言模型作为眼科手稿的内部一致性检查。

IF 4.4 3区医学

Eye Pub Date : 2026-10-09 DOI: 10.1038/s41433-026-04965-5

Ethan La, Jai Paris, Ayushi Agarwal, Weng Onn Chan, Dinesh Selva

引用次数: 0

MOG-associated optic neuritis in a 4-year-old child presenting with papillary and preretinal haemorrhages. 4岁儿童mog相关视神经炎，表现为乳头状和视网膜前出血。

IF 4.4 3区医学

Eye Pub Date : 2026-10-08 DOI: 10.1038/s41433-026-04905-3

Matheus Almeida, Rutika Dodeja

引用次数: 0

Efficacy and safety of port delivery platform with ranibizumab (PDS) for diabetic macular oedema (Pagoda Randomised Clinical Trial). 雷尼单抗（PDS）港口给药平台治疗糖尿病黄斑水肿的有效性和安全性（宝塔随机临床试验）。

IF 4.4 3区医学

Eye Pub Date : 2026-10-08 DOI: 10.1038/s41433-026-04840-3

Shamika Gune, Mel Rabena, Ashwini Bobbala

引用次数: 0

Post-treatment residual masses in orbital lymphoma: incidence, risk factors, and prognostic impact. 眼眶淋巴瘤治疗后残留肿块：发病率、危险因素和预后影响。

IF 4.4 3区医学

Eye Pub Date : 2026-10-08 DOI: 10.1038/s41433-026-04918-y

Yeong A Choi, Min Kyu Yang, Ho-Seok Sa

{"title":"Post-treatment residual masses in orbital lymphoma: incidence, risk factors, and prognostic impact.","authors":"Yeong A Choi, Min Kyu Yang, Ho-Seok Sa","doi":"10.1038/s41433-026-04918-y","DOIUrl":"https://doi.org/10.1038/s41433-026-04918-y","url":null,"abstract":"Purpose: We aimed to evaluate the incidence and risk factors for residual masses (RMs) following first-line treatment of primary orbital lymphoma (OL) and identify predictors of local recurrence (LR) and systemic relapse (SR) among patients with RMs.Methods: This retrospective study included 100 individuals with OL who received treatment and were followed for over 6 months. Clinical characteristics were reviewed, and treatment responses were assessed at 12 and 24 weeks post-treatment and at the last follow-up. Risk factors for RM presence, persistence, LR, and SR were analysed.Results: The mean age was 57.1 years, with a male predominance (61%) and a median follow-up of 58.2 months. Histological subtypes included extranodal marginal zone lymphoma (EMZL, n = 85), diffuse large B-cell lymphoma (DLBCL, n = 12), and mantle cell lymphoma (MCL, n = 3). Residual masses were identified in 73% of participants at 12 weeks post-treatment. Residual mass presence was significantly associated with tumour size ≥25 mm, AJCC N1/M1 stage, and location in the posterior orbit or with extraocular muscle involvement (each P < 0.05). All LR (n = 19) and SR (n = 8) cases occurred exclusively in patients with RMs. Local recurrence was significantly associated with N1 disease (P < 0.001), while SR correlated with high-grade histological subtypes, such as DLBCL and MCL (P = 0.026).Conclusion: Post-treatment RMs were common in OL, particularly among individuals with advanced-stage, large, or posteriorly located tumours. Among those with RMs, AJCC N1 stage and high-grade histology were independent predictors of relapse. Given the risk of relapse despite standard first-line therapy, intensified treatment and closer surveillance should be considered in this high-risk subgroup.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combined limbal dysmaturation and microcyst like epithelial changes with corneal nerve alterations of a novel anti nectin-4-MMAE antibody drug conjugate. 一种新型抗nectin-4-MMAE抗体药物偶联物联合角膜缘发育不良和微囊样上皮改变与角膜神经改变。

IF 4.4 3区医学

Eye Pub Date : 2026-10-08 DOI: 10.1038/s41433-026-04976-2

Marwa Deiri, Rafael Boucher, Cédric Pobel, Jacopo Uliano, Yohann Loriot, Kaissa Ouali, Marc Labetoulle, Antoine Rousseau

引用次数: 0

Rapid asymmetric cataract progression in patients following GLP-1 receptor agonist therapy: case series. GLP-1受体激动剂治疗后患者的快速不对称白内障进展：病例系列。

IF 4.4 3区医学

Eye Pub Date : 2026-10-07 DOI: 10.1038/s41433-026-04971-7

Mahmoud Eissa, Abdullah Hassan, Mohamed Osman, Omar Mehana, Ahmed Elsayed

引用次数: 0

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