Eye最新文献

{"title":"Current and emerging strategies for myopia control: a narrative review of optical, pharmacological, behavioural, and adjunctive therapies.","authors":"Furqan A Maulvi, Ditixa T Desai, Parthasarathi Kalaiselvan, Dinesh O Shah, Mark D P Willcox","doi":"10.1038/s41433-025-03949-1","DOIUrl":"https://doi.org/10.1038/s41433-025-03949-1","url":null,"abstract":"<p><p>Myopia has become a leading cause of visual impairment globally, with a rapidly increasing prevalence among children, particularly in urbanised areas of East and Southeast Asia. High and pathologic myopia can lead to irreversible complications, including retinal detachment, glaucoma, and myopic maculopathy. This narrative review synthesises current and emerging strategies for myopia control as of 2025, integrating evidence from optical, pharmacological, behavioural, and surgical domains. Multifocal contact lenses, orthokeratology, and defocus-incorporated spectacles are effective in modulating axial elongation. Low-dose atropine remains a cornerstone pharmacologic therapy with consistent efficacy. Behavioural interventions, such as increased outdoor time, provide preventive benefits and are endorsed in school-based programs. Repeated low-level red-light (RLRL) therapy represents a novel, non-invasive option with growing support. Surgical approaches, while corrective rather than preventive, are relevant in advanced cases. The review also compares intervention efficacy, discusses the rationale for combination therapies, and highlights the need for individualised, age-appropriate strategies. Key challenges include treatment variability, limited long-term data, and barriers to adherence and access. Future directions involve personalised risk prediction, global implementation frameworks, and public health engagement. A multimodal, patient-centred approach is essential to reduce the lifelong burden of myopia.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-surgical interventions for proliferative vitreoretinopathy-a systematic review.","authors":"Guy Hunter, Nairn Maclean, Stephanie Watson, Marcus Colyer, James Leong, Rupesh Agrawal, Scott F McClellan, Kyle E Miller, Fasika A Woreta, Matthew C Caldwell, Tom Williamson, William Gensheimer, Kara Cavuoto, Annette K Hoskin, Andrés Rousselot Ascarza, William G Felipe Dhawahir-Scala, Gangadhara Sundar, Robert A Mazzoli, Peter Shah, Malcolm Woodcock, Ferenc Kuhn, Renata Sm Gomes, Grant A Justin, Richard J Blanch","doi":"10.1038/s41433-025-03846-7","DOIUrl":"10.1038/s41433-025-03846-7","url":null,"abstract":"<p><p>Proliferative Vitreoretinopathy (PVR) is the most common cause of surgical failure after retinal detachment (RD) repair, complicating up to 10% of spontaneous RD repairs and 50% of open globe injury-related RD. Early surgical intervention is currently the only intervention that reduces PVR incidence. An effective non-surgical intervention would be valuable in reducing PVR incidence and/or severity, particularly where access to surgery is limited or may be delayed. To define the evidence base for non-surgical management options to prevent and treat Proliferative Vitreoretinopathy (PVR) in retinal detachment and trauma, we searched PubMed, Clinicaltrials.gov, Medline and CINAHL for randomised controlled trials (RCTs) of non-surgical interventions to prevent or treat established PVR with no restriction on language or start date up until November 2024. All non-surgical interventions were considered with no restrictions. We considered outcomes of post-operative PVR (including retinal reattachment rate) and visual acuity and performed Risk of Bias (RoB) assessments using the Cochrane RoB2 tool. We identified 27 papers which included 1981 patients in studies of primary prevention and 1394 patients in studies of treatment of established PVR. While several studies of various agents individually demonstrated some improvements, the reviewers found concerns with RoB and the results were not replicated in the larger included studies. Multiple studies have investigated non-surgical interventions for PVR after RRD repair and trauma, but none have yet demonstrated clinically significant, repeatable benefits. Improved understanding of PVR pathobiology, along with larger prospective studies of existing preventative strategies may lead to the development of newer and more effective interventions.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"2124-2142"},"PeriodicalIF":2.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274627/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optic disc morphology in congenital glaucoma.","authors":"Arnav Panigrahi, Nikhil Sawant, Manzoor Ahmad Malik, Shikha Gupta, Anurag Kumar, Swati Phuljhele, Parul Sony, Viney Gupta","doi":"10.1038/s41433-025-03839-6","DOIUrl":"10.1038/s41433-025-03839-6","url":null,"abstract":"<p><strong>Objectives: </strong>This cross sectional study aimed to evaluate the optic disc morphology with respect to the optic disc size, tilt and torsion in eyes of children with congenital glaucoma.</p><p><strong>Methods: </strong>Children with congenital glaucoma (controlled with therapy), including primary congenital glaucoma (PCG) and those with Axenfeld-Rieger Malformation (ARM) who were now cooperative for fundus photography and scanning laser ophthalmoscopy, were recruited. Controls were age and gender matched children, who were following up at our institute for refractive error or had undergone strabismus surgery before the age of 3 years and were now old enough to cooperate for a fundus photography. Fundus photographs were evaluated using Image J processing software to obtain optic disc tilt and torsion. Axial length (AL) and optic disc area (DA) were correlated with the disc tilt and torsion. The axial length, optic disc area, optic disc tilt, optic disc torsion were compared between affected eyes with PCG with those of healthy controls and the unaffected eyes of unilateral PCG as well as between PCG and those with ARM.</p><p><strong>Results: </strong>Affected eyes of children with PCG (n = 109) had a DA (2.3 ± 0.7 mm² vs. 2.1 ± 0.5 mm²), disc tilt (1.1 ± 0.1 vs. 1.1 ± 0.2) and disc torsion (median 10 vs. 6 degree) not significantly different (p = 0.8, p = 1, p = 0.61 respectively) from eyes of healthy children (n = 96). Mean AL in PCG eyes was significantly greater (p < 0.028) than in healthy control eyes and correlated with the DA in PCG eyes (Pearson correlation=0.32, p = 0.014). Affected eyes of children with unilateral congenital glaucoma (n = 33) had a DA (2.3 ± 0.54 mm² vs. 2.1 ± 0.54 mm²), disc tilt (1.1 ± 0.09 vs. 1.1 ± 0.1) and disc torsion (median 10 vs. 10 degree) not significantly different (p = 0.64, p = 0.1, p = 0.75 respectively) from the unaffected eyes. However, eyes of patients with ARM had higher disc torsion compared to controls (p = 0.043).</p><p><strong>Conclusion: </strong>Despite axial elongation, the optic disc morphology of children with primary congenital glaucoma are not significantly different from healthy controls.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"2211-2216"},"PeriodicalIF":2.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274620/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early ophthalmological tumour signs and diagnostic interval in children with brain tumours.","authors":"Jacob Christiansen, René Mathiasen, Steffen Heegaard, Sia Kjeldsen, Kjeld Schmiegelow, Volkert Siersma, Sarah Linea von Holstein","doi":"10.1038/s41433-025-03837-8","DOIUrl":"10.1038/s41433-025-03837-8","url":null,"abstract":"<p><strong>Background: </strong>Children with brain tumours often suffer from late diagnosis, impacting cure rates and risk of permanent sequelae. Ophthalmological symptoms are common, and we aimed to investigate the frequency, diagnostic interval, and prognostic value of early-onset ophthalmological brain tumour signs.</p><p><strong>Methods: </strong>The study is based on data from national Danish health registries and medical files from hospitals and private ophthalmologists collected from all children diagnosed with a primary brain tumour in Denmark during 2007-2017.</p><p><strong>Results: </strong>Among 437 included children, 51.7% (n = 226) had ophthalmological tumour signs prior to diagnosis, and 10.8% (n = 47) had ophthalmological symptoms as their initial tumour manifestation. The most common ophthalmological signs in total before diagnosis were reduced visual acuity (n = 73; 16.7%), diplopia (n = 65; 14.9%), abnormal optic nerve (n = 59; 13.5%), and strabismus (n = 50; 11.4%). The median time from initial symptom onset to diagnosis was 12.6 weeks for all children, 15.9 weeks for those with ophthalmological symptoms as their initial tumour sign (p = 0.28), and 12.5 weeks for those with ophthalmological tumour signs at any time before diagnosis (p = 0.71). Children with ophthalmological signs before diagnosis had a higher risk of death (HR: 2.11; 95% CI: 1.32-3.39; p = 0.002).</p><p><strong>Conclusions: </strong>Ophthalmological tumour signs are frequent in children with brain tumours, and the diagnostic interval is long regardless of ophthalmological tumour signs being present or not. Taken together with the higher risk of death in the group with ophthalmological tumour signs, this study emphasises the importance of the ophthalmological assessment to ensure timely diagnosis.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"2245-2252"},"PeriodicalIF":2.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting post-surgery change in visual acuity after successful repair of macula-off retinal detachments: findings from a large prospective UK cohort study.","authors":"David Yorston, Paul H J Donachie, D A Laidlaw, David H Steel, Tom H Williamson","doi":"10.1038/s41433-025-03752-y","DOIUrl":"10.1038/s41433-025-03752-y","url":null,"abstract":"<p><strong>Objective: </strong>To identify risk factors affecting the change in visual acuity in successfully re-attached macula-off rhegmatogenous retinal detachment (RD) surgery.</p><p><strong>Design: </strong>A cohort study, using an online database, of visual outcomes for 2770 macula-off retinal detachments that were successfully re-attached by vitrectomy and internal tamponade. The database included detailed retinal diagrams of each detachment.</p><p><strong>Main outcome measure: </strong>The change in LogMAR visual acuity from pre-operatively to post-operatively.</p><p><strong>Results: </strong>Male patients accounted for 64.6% of the sample and the median age was 63 years old. The median pre-operative VA was counting fingers (LogMAR 1.98); this improved to 0.30 LogMAR post-operatively. An improvement in VA of ≥0.30 LogMAR was achieved by 88.0% eyes. The change in VA model identified the preoperative VA, patient age, duration of central vision loss, lens status at follow up, extent of detachment, and the number of breaks in the detached retina, as factors influencing the change in VA. The model had an adjusted R² of 0.749, and for 75.5% of eyes, the model prediction was within ±0.30 LogMAR of the recorded VA change.</p><p><strong>Conclusions: </strong>Greater post-operative visual acuity improvement was more likely in eyes that were pseudophakic at follow up, and had shorter durations of central vision loss. Non modifiable factors associated with greater vision improvement included worse presenting vision, younger age, less extensive detachment and less than three breaks in the detached retina. These results confirm that prompt surgery improves functional outcomes in successfully treated macula off retinal detachments irrespective of presenting visual acuity.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"2298-2306"},"PeriodicalIF":2.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274463/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144150033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining the limits of upper and lower conjunctival fornix depths in a healthy Asian Chinese population.","authors":"See Teng Tan, Hla Myint Htoon, Matthew Davidson, Saaeha Rauz, Jodhbir S Mehta, Hon Shing Ong","doi":"10.1038/s41433-025-03828-9","DOIUrl":"10.1038/s41433-025-03828-9","url":null,"abstract":"<p><strong>Background: </strong>The early detection of conjunctival fornix shortening is essential for the effective management of progressive cicatrising conjunctival diseases. Establishing a baseline reference for conjunctival scarring by determining the normative conjunctival fornix depths (FDs) allows for the measurement and monitoring of changes in the conjunctiva. This study explored anatomical variations in conjunctival FDs amongst an Asian Chinese population, providing valuable information for conjunctival fibrosis assessment.</p><p><strong>Methods: </strong>This retrospective study conducted at a single centre included 295 Chinese individuals (590 eyes) with normal conjunctiva who visited the eye clinic between 2019 and 2023. The lower and upper FDs were assessed using a validated FD measurer (FDM). Mean lower and upper FDs were calculated and stratified by age and gender.</p><p><strong>Results: </strong>The mean upper and lower conjunctival FDs for the Chinese population in Singapore were 16.1 mm ± 1.6 (95% CI, 15.9-16.2) and 10.1 mm ± 1.7 (95% CI, 10.0-10.3), respectively. Females exhibited shorter FDs (upper 15.7 mm ± 1.5; lower 9.8 mm ± 1.5) compared to males (upper 16.5 mm ± 1.5; lower 10.5 mm ± 1.9) (p < 0.001). Linear regression analysis demonstrated a significant inverse correlation between age and FDs, indicating that FDs decreases with advancing age (R² = 0.1469 for upper and 0.3195 for lower fornices; p < 0.001). Specifically, the mean upper FD ranged from 17.4 mm (95% CI, 17.2-17.7) in the 20-29 age group to 15.2 mm (95% CI, 14.9-15.5) in the 80-89 age group. Similarly, the mean lower FD ranged from 12.0 mm (95% CI, 11.6-12.4) in the 20-29 age group to 8.7 mm (95% CI, 8.5-9.0) in the 80-89 age group. Analysis of the 95% CIs revealed no statistical difference in FD measurements when compared to published Caucasians, South Asians, and Turkish populations.</p><p><strong>Conclusions: </strong>This study adds to the available literature a set of normative data for upper and lower FD in a Chinese population, highlighting gender-related variations and age-related progressive conjunctival shrinkage. The established dataset serves as a valuable resource for clinicians, enabling them to better manage and monitor patients with conjunctival diseases. These normative values in forniceal depths adds to available data obtained from Caucasian, South Asian, and Turkish eyes. Existing clinical assessment tools incorporating FD measurements, but validated in other ethnic populations, can be used in Chinese populations.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"2289-2297"},"PeriodicalIF":2.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274369/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between leukocyte telomere length and incident glaucoma: A prospective UK biobank study.","authors":"Jun Yu, Yuzhou Zhang, Chi Pui Pang, Clement C Tham, Jason C Yam, Li Jia Chen","doi":"10.1038/s41433-025-03838-7","DOIUrl":"10.1038/s41433-025-03838-7","url":null,"abstract":"<p><strong>Background: </strong>Leukocyte telomere length (LTL) has been associated with various diseases, including age-related eye diseases such as cataract and age-related macular degeneration. However, the role of LTL in the longitudinal development of glaucoma is still unknown. Here we prospectively evaluate the association of LTL with glaucoma incidence and related traits, in the UK Biobank cohort.</p><p><strong>Methods: </strong>The study cohort included 419,603 participants with complete baseline data for glaucoma analyses. Multivariable Cox proportional hazards models were used to evaluate the association between LTL and the risk of glaucoma incidence, and multivariable linear regression was employed to test the association between LTL and glaucoma-related traits.</p><p><strong>Results: </strong>During a 13.58-year follow-up period, 7385 (1.76%) participants developed glaucoma. No association between LTL and incident glaucoma was found in either Model 1 (adjusted for age, sex, ethnicity and the ancestry components; HR = 1.011, 95% CI: 0.990-1.033; P = 0.311), or Model 2 (additionally adjusted for smoking status, alcohol consumption, body mass index, systolic blood pressure, education level, Townsend Deprivation Index, polygenic risk score for glaucoma, and history of diabetes and cardiovascular diseases; HR = 1.010, 95% CI: 0.988-1.032; P = 0.367). Non-significant associations were also observed for glaucoma-related traits, including the retinal nerve fibre layer, ganglion cell-inner plexiform layer, and intraocular pressure with LTL (all P-values > 0.05), but LTL was associated with a slightly increased vertical cup-to-disc ratio (P = 0.009).</p><p><strong>Conclusions: </strong>This study suggested that LTL is not a major biomarker for incident glaucoma in the UK Biobank population. Further studies in different populations are warranted.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"2176-2182"},"PeriodicalIF":2.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo analysis of iridocorneal angle parameters with spectral-domain optical coherence tomography in children with Neurofibromatosis type 1.","authors":"Murat Gunay, Ibrahim Mert Kurt, Ugur Yilmaz, Adem Turk, Dilek Uzlu, Busra Kose, Pinar Ozkan Kart, Ali Cansu","doi":"10.1038/s41433-025-03840-z","DOIUrl":"10.1038/s41433-025-03840-z","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate iridocorneal angle (ICA) parameter measurements with spectral-domain optical coherence tomography (SD-OCT) in children with Neurofibromatosis type 1 (NF1) and to compare them with those in healthy children.</p><p><strong>Methods: </strong>Twenty children with NF1 and 33 age- and sex-matched healthy controls were enroled. All subjects underwent ICA imaging with SD-OCT. Schlemm canal diameter (SCD), anterior chamber angle (ACA), angle opening distance (AOD500 and AOD750), trabecular-iris space area (TISA500 and TISA750) and scleral spur length (SSL) were examined in the temporal sections and measured with customized software. Also, iris thickness (IT) was measured as the distances between the anterior and posterior iris surface, at 1 mm (IT-1), 2 mm (IT-2) and 3 mm (IT-3) from the edge of the pupil.</p><p><strong>Results: </strong>Mean ACD was significantly narrower in NF1 group (p = 0.003). Mean levels of SCD (p < 0.001), ACA (p = 0.001), AOD500 (p = 0.001), AOD750 (p < 0.001), TISA500 (p < 0.001) and TISA750 (p < 0.001) were significantly lower in NF1 group. Mean SSL-1 (p = 0.19) and SSL-2 (p = 0.56) measurements were found to be similar between the groups. Mean IT-1 (p < 0.001), IT-2 (p < 0.001) and IT-3 (0.03) were observed to be significantly higher in NF1 group. There was significant correlation between ACD and IT. Also, ACD and IT showed significant associations with the ICA parameters.</p><p><strong>Conclusion: </strong>There was a significantly narrower ICA morphology in NF1 children. SCD was significantly decreased in children with NF1. A significantly thicker iris in NF1 children may offer a possible impact of iris morphology on narrower ICA parameters and SCD.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"2217-2222"},"PeriodicalIF":2.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The safety and effectiveness of optometrist-delivered selective laser trabeculoplasty.","authors":"Alexander Geoffrey Swystun, Elizabeth Langton, Susanne Kelly, Divya Venugopal, David Burton, Jan van der Hoek, Joanna Liput, Pouya Alaghband","doi":"10.1038/s41433-025-03857-4","DOIUrl":"10.1038/s41433-025-03857-4","url":null,"abstract":"<p><strong>Background: </strong>Selective laser trabeculoplasty (SLT) has been demonstrated to have an IOP-lowering effect similar to topical medication when used as a first-line treatment. Accordingly, demand for SLT has increased, requiring other allied health care professionals to be leveraged in the delivery of this service. Current evidence on the safety of optometrists performing SLT is sparse. The aim of this study was to assess the success rate of SLT delivered by optometrists in eyes with newly diagnosed ocular hypertension and/or glaucoma and individuals who had received SLT as a treatment escalation. The secondary aim of the study was to assess complications of SLT delivered by optometrists.</p><p><strong>Methods: </strong>This was a retrospective study. Success rate was defined as ≥20% reduction in intraocular pressure (IOP), or the cessation of ≥1 class of anti-glaucoma medication in cases of treatment escalation. For the first-line treatment, success was quantified according to the disease diagnosis with specified levels of IOP reduction.</p><p><strong>Results: </strong>880 eyes of 574 patients were included in the analysis. The success rate was 70.9% (244/344) in eyes with first-line SLT, whilst 65.3% (343/525) in the treatment escalation group. Overall, adverse events were identified in 2.2% of cases, including uveitis (0.92%), post-procedure transient IOP spike (0.45%), allergic reaction (0.23%), dry eye (0.23%), headache (0.11%), hyphaema (0.11%), and vitreo-macular traction 0.11%).</p><p><strong>Conclusion: </strong>Optometrists delivered a safe and effective selective laser trabeculoplasty treatment with low rates of adverse events. Inter-optometrist differences in success rates were identified that require further elucidation.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"2284-2288"},"PeriodicalIF":2.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144110069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to 'Comment on: 'Comparing safety and efficacy of Bevacizumab, Ranibizumab and Ranibizumab biosimilar in Retinopathy of prematurity\".","authors":"Puja Maitra, Parag K Shah","doi":"10.1038/s41433-025-03876-1","DOIUrl":"10.1038/s41433-025-03876-1","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"2321"},"PeriodicalIF":2.8,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274467/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}