Eye最新文献

{"title":"Conjunctival tick bite.","authors":"Kun Hsi Chu, Alexander Kwok, Adriana Paula Grigorian, John B Block, Eric Rosenbaum, Abdelrahman M Elhusseiny","doi":"10.1038/s41433-025-03770-w","DOIUrl":"https://doi.org/10.1038/s41433-025-03770-w","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chat GPT vs an experienced ophthalmologist: evaluating chatbot writing performance in ophthalmology.","authors":"Gabriel Katz, Ofira Zloto, Avner Hostovsky, Ruth Huna-Baron, Iris Ben-Bassat Mizrachi, Zvia Burgansky, Alon Skaat, Vicktoria Vishnevskia-Dai, Ido Didi Fabian, Oded Sagiv, Ayelet Priel, Benjamin S Glicksberg, Eyal Klang","doi":"10.1038/s41433-025-03779-1","DOIUrl":"https://doi.org/10.1038/s41433-025-03779-1","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the abilities of ChatGPT in writing scientific ophthalmology introductions and to compare those abilities to experienced ophthalmologists.</p><p><strong>Methods: </strong>OpenAI web interface was utilized to interact with and prompt ChatGPT 4 for generating the introductions for the selected papers. Consequently, each paper had two introductions-one drafted by ChatGPT and the other by the original author. Ten ophthalmology specialists with a minimal experience of more than 15 years, each representing distinct subspecialties-retina, neuro-ophthalmology, oculoplastic, glaucoma, and ocular oncology were provided with the two sets of introductions without revealing the origin (ChatGPT or human author) and were tasked to evaluate the introductions.</p><p><strong>Results: </strong>For each type of introduction, out of 45 instances, specialists correctly identified the source 26 times (57.7%) and erred 19 times (42.2%). The misclassification rates for introductions were 25% for experts evaluating introductions from their own subspecialty while to 44.4% for experts assessed introductions outside their subspecialty domain. In the comparative evaluation of introductions written by ChatGPT and human authors, no significant difference was identified across the assessed metrics (language, data arrangement, factual accuracy, originality, data Currency). The misclassification rate (the frequency at which reviewers incorrectly identified the authorship) was highest in Oculoplastic (66.7%) and lowest in Retina (11.1%).</p><p><strong>Conclusions: </strong>ChatGPT represents a significant advancement in facilitating the creation of original scientific papers in ophthalmology. The introductions generated by ChatGPT showed no statistically significant difference compared to those written by experts in terms of language, data organization, factual accuracy, originality, and the currency of information. In addition, nearly half of them being indistinguishable from the originals. Future research endeavours should explore ChatGPT-4's utility in composing other sections of research papers and delve into the associated ethical considerations.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering shuttlecock cataract morphology using anterior segment optical coherence tomography.","authors":"Aafreen Bari, Himanshu Khandelwal, Chetan Shakkarwal, Hemant Jhajharia, Namrata Sharma","doi":"10.1038/s41433-025-03757-7","DOIUrl":"https://doi.org/10.1038/s41433-025-03757-7","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early intraocular pressure dynamics following aflibercept 8 mg versus aflibercept 2 mg: a propensity score-matched analysis.","authors":"Valentina Sarao, Daniele Veritti, Francesco Bonini, Asia Amelia Martin, Paolo Lanzetta","doi":"10.1038/s41433-025-03765-7","DOIUrl":"https://doi.org/10.1038/s41433-025-03765-7","url":null,"abstract":"<p><strong>Purpose: </strong>To compare early intraocular pressure (IOP) dynamics following intravitreal injections of aflibercept 8 mg versus aflibercept 2 mg using propensity score-matched analysis with fellow eye controls.</p><p><strong>Methods: </strong>This prospective observational study included treatment-naïve patients with neovascular age-related macular degeneration (AMD) or diabetic macular oedema (DMO). Patients received aflibercept 8 mg or 2 mg based on investigator discretion. IOP was measured using iCare rebound tonometry at baseline (T0), 1 min (T1), 10 min (T2), 30 min (T3), and 3 months (T4) after the initial treatment. Untreated fellow eyes served as controls. Secondary analyses evaluated predictors of significant IOP elevation.</p><p><strong>Results: </strong>A total of 1820 IOP measurements from 140 eyes (35 treated with aflibercept 8 mg and 35 with aflibercept 2 mg and their respective untreated fellow eyes) were analysed. Both formulations induced significant immediate IOP elevations at T1 (55.6 ± 15.2 mmHg for 8 mg, 54.2 ± 20.4 mmHg for 2 mg) compared to baseline values (p < 0.001). Pressures decreased progressively, approaching baseline by T3 (19.3 ± 5.9 mmHg for 8 mg, 20.5 ± 6.6 mmHg for 2 mg), with no significant differences between doses (p > 0.05). Pre-existing glaucoma emerged as the strongest predictor of sustained IOP elevation, while DMO eyes exhibited higher initial spikes compared to neovascular AMD. Three-month IOP remained stable across both groups.</p><p><strong>Conclusions: </strong>Intravitreal administration of aflibercept 8 mg demonstrates IOP dynamics comparable to the 2 mg formulation, with rapid normalization of pressure spikes by 30 min. These findings suggest enhanced monitoring may be beneficial for patients with glaucoma or DMO.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coats-like vasculopathy in patients with an inherited retinal disease: a case series and literature review.","authors":"Neofytos Mavris, Brice Nguedia Vofo, Samer Khateb, Jaime Levy","doi":"10.1038/s41433-025-03778-2","DOIUrl":"10.1038/s41433-025-03778-2","url":null,"abstract":"<p><strong>Objective: </strong>To examine clinical characteristics, genetic associations, and visual outcomes of Coats-like vasculopathy (CLV) in patients with inherited retinal disease (IRD).</p><p><strong>Methods: </strong>A literature review of studies published through December 30, 2023, and a cohort analysis of cases from Hadassah Medical Center were conducted. Data from 47 studies (163 patients, 277 eyes) and 10 institutional cases (17 eyes) were analysed using descriptive statistics.</p><p><strong>Results: </strong>Two novel CLV-associated genes, LRP5 and KIZ, were identified in our cohort. Literature findings showed that 69.9% of cases had bilateral asymmetric CLV, with 38.7% of patients being legally blind at their final assessment. The mean interval between IRD onset and CLV diagnosis was 10.38 ± 10.23 years. While baseline best-corrected visual acuity (BCVA) showed no significant difference between unilateral CLV-affected vs. non-CLV-affected eyes (51.19 vs. 72 ETDRS letters, respectively; p = 0.051), BCVA was significantly different at CLV onset (29.19 vs. 69.12 ETDRS letters, respectively; p < 0.001) and at the final visit (19.93 vs. 63.55 ETDRS letters, respectively; p < 0.001). Visual outcomes were similar across treatment modalities (laser, cryotherapy ± laser).</p><p><strong>Conclusions: </strong>CLV in IRD patients demonstrates clinical and genetic heterogeneity, with significant visual impairment regardless of treatment. The discovery of LRP5 and KIZ expands the genetic landscape of CLV. The profound and progressive vision loss in CLV-affected eyes underscores the need for early detection and tailored management strategies.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing patient satisfaction and outcomes from the newly established virtual oculoplastic photography (VOP) clinic in a secondary care centre.","authors":"Daniel Curry, Scott Cutting, Sarju Athwal, Mona Khandwala","doi":"10.1038/s41433-025-03766-6","DOIUrl":"https://doi.org/10.1038/s41433-025-03766-6","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroretinography of disease activity and treatment response in birdshot chorioretinopathy.","authors":"Christopher R Rosenberg, Elizabeth White, Aseel Alsamarraie, Sandip Suresh, Wayne Tschetter, Dongseok Choi, Rene Y Choi, Richard G Weleber, James T Rosenbaum, Phoebe Lin, Mark E Pennesi, Eric B Suhler, Paul Yang","doi":"10.1038/s41433-025-03769-3","DOIUrl":"https://doi.org/10.1038/s41433-025-03769-3","url":null,"abstract":"<p><strong>Purpose: </strong>To identify full-field electroretinographic (ffERG) biomarkers that differentiate active versus inactive birdshot chorioretinopathy (BSCR) and long-term efficacy of intravitreal versus systemic immunosuppression.</p><p><strong>Methods: </strong>Patients with BSCR at Casey Eye Institute with ffERG between 1999-2019 were included (n = 29). A group of healthy patients was used as controls (n = 47). Patients with BSCR were categorized as active or inactive based on the uveitis specialist's clinical assessment. Cross-sectional comparison of ffERG markers between active, inactive, and control patients was performed, in addition to rate analysis of ffERG metrics in BSCR eyes treated with either intravitreal fluocinolone acetonide 0.59 mg (IVFAI) or systemic immunomodulation (SI).</p><p><strong>Results: </strong>Both active and inactive BSCR tended to have lower amplitude and slower timing than controls, but only 30 Hz flicker time (p < 0.001, p < 0.01) and dim scotopic b-wave amplitude (p < 0.001, p < 0.05) were significant. Timing for inactive BSCR was faster than active for bright scotopic a-wave (p < 0.01), photopic b-wave (p < 0.01), and 30 Hz flicker (p < 0.01). Eyes treated with SI showed improvement in dim scotopic b-wave amplitude compared to a decline for IVFAI (p < 0.05), whereas eyes treated with SI showed slower degradation of bright scotopic b-wave amplitude (p < 0.01). Conversely, eyes treated with IVFAI showed greater improvement in bright scotopic (p < 0.05) and photopic a-wave timing (p < 0.01).</p><p><strong>Conclusions: </strong>Timing of 30 Hz flicker, bright scotopic a-wave, and photopic b-wave may be useful biomarkers for disease activity in BSCR. Moreover, both SI and IVFAI were effective in preserving retinal function to varying degrees.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic accuracy of optic nerve OCT and ultrasound in a large paediatric cohort referred with suspected papilloedema and very low rates of raised ICP.","authors":"Christy Ambrose, Kirsten Graham, Ruth Hamilton, Anne Cees Houtman","doi":"10.1038/s41433-025-03764-8","DOIUrl":"https://doi.org/10.1038/s41433-025-03764-8","url":null,"abstract":"<p><strong>Background/objectives: </strong>The Honey Rose trial increased referrals for suspected papilloedema. We audited such referrals from community optometrists and used long-term patient outcomes to investigate the diagnostic accuracy of OCT retinal nerve fibre layer (RNFL) thickness and B scan ultrasound optic nerve sheath diameter (ONSD) for raised intracranial pressure (rICP).</p><p><strong>Subjects/methods: </strong>Audit of 337 children seen in a 'blurry disc' clinic. Long-term outcomes (6-42 months) were used to classify children as with or without raised ICP. Receiver operating curves investigated diagnostic accuracy of RNFL and ONSD cut-off values. Regression modelling investigated potential predictive variables for rICP.</p><p><strong>Results: </strong>310/337 children (92%) were discharged, 75 of whom were reviewed due to some clinical suspicion. 27/337 children (8%) were referred to other specialists, of whom 18 had rICP (16 IIH, one intra-cranial tumour, one arachnoid cyst). RNFL thickness cut-off >144 µm at 95% specificity had 83% sensitivity (95% CI 61-100%) and ONSD cut-off >4.99 mm at 90% specificity had 82% sensitivity (95% CI 50-100%) for rICP. Increased RNFL thickness, increased ONSD and presence of symptoms all contributed to prediction of rICP: acuity, age, sex and all other OCT parameters did not.</p><p><strong>Conclusions: </strong>95% (319/337) of children referred with suspected papilloedema did not have raised ICP. Almost three-quarters of children referred (253/337, 70%) would have been more appropriately managed in community optometry. OCT RNFL and ONSD cut-offs show promising diagnostic accuracy for rICP in this study. There is a clear need to support community optometry to resume management of most children with suspected papilloedema.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The global burden and attributable risk factor analysis of age-related macular degeneration in 204 countries and territories, 1990-2021.","authors":"Jun Wang, Jin Han, Xuze Wang, Wei Han","doi":"10.1038/s41433-025-03774-6","DOIUrl":"https://doi.org/10.1038/s41433-025-03774-6","url":null,"abstract":"<p><strong>Objectives: </strong>To report the global burden of age-related macular degeneration (AMD) and associated risk factors between 1990 and 2021 by age, sex, and sociodemographic index (SDI) and to investigate the influence of the COVID-19 pandemic on AMD burden.</p><p><strong>Methods: </strong>Data on disability-adjusted life years (DALYs) of AMD were obtained from the Global Burden of Disease Study 2021. Joinpoint regression determined annual percentage change (APC) and average annual percentage change (AAPC). ARIMA model projected AMD burden trends, with additional analyses for frontier, decomposition, and health inequality.</p><p><strong>Results: </strong>Globally, AMD accounted for 578.02 (95% UI: 401.24-797.57) thousand DALYs in 2021, driven by population growth and aging. Age-standardized DALY rates (ASDRs) fell from 1990 to 2021 (AAPC: -0.69, 95%CI: -0.77 to -0.6), but increased in high-middle and middle SDI regions during the initial two years of the pandemic. ARIMA model forecasts a worldwide decline in ASDRs over the next 29 years. Sex disparities were significant, with women having continuously higher ASDRs, especially from 2019 to 2021. Despite some reduction in health inequality, an inverse SDI-ASDR relationship indicated ongoing socioeconomic disparities. Frontier analysis showed improvement potential across growth stages. Smoking-related AMD burden decreased globally, with a correlation between national ASDRs and PM_2.5 levels.</p><p><strong>Conclusions: </strong>ASDRs due to AMD have decreased over the past 32 years, while DALYs have substantially increased. The burden is more heavily tilted toward women, the elderly, and less-developed countries, with COVID-19 further intensifying the situation. Addressing the burden requires focusing on smoking cessation and air quality improvements.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exudative retinal detachment as a presentation of systemic lupus erythematosus (SLE).","authors":"Ashish Markan, Manasi Tripathi, Vipin Rana, Amit Nandan Tripathi","doi":"10.1038/s41433-025-03758-6","DOIUrl":"https://doi.org/10.1038/s41433-025-03758-6","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}