Murat Gunay, Ibrahim Mert Kurt, Ugur Yilmaz, Adem Turk, Dilek Uzlu, Busra Kose, Pinar Ozkan Kart, Ali Cansu
{"title":"1型神经纤维瘤病儿童虹膜角膜角谱域相干断层扫描的体内分析","authors":"Murat Gunay, Ibrahim Mert Kurt, Ugur Yilmaz, Adem Turk, Dilek Uzlu, Busra Kose, Pinar Ozkan Kart, Ali Cansu","doi":"10.1038/s41433-025-03840-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate iridocorneal angle (ICA) parameter measurements with spectral-domain optical coherence tomography (SD-OCT) in children with Neurofibromatosis type 1 (NF1) and to compare them with those in healthy children.</p><p><strong>Methods: </strong>Twenty children with NF1 and 33 age- and sex-matched healthy controls were enroled. All subjects underwent ICA imaging with SD-OCT. Schlemm canal diameter (SCD), anterior chamber angle (ACA), angle opening distance (AOD500 and AOD750), trabecular-iris space area (TISA500 and TISA750) and scleral spur length (SSL) were examined in the temporal sections and measured with customized software. Also, iris thickness (IT) was measured as the distances between the anterior and posterior iris surface, at 1 mm (IT-1), 2 mm (IT-2) and 3 mm (IT-3) from the edge of the pupil.</p><p><strong>Results: </strong>Mean ACD was significantly narrower in NF1 group (p = 0.003). Mean levels of SCD (p < 0.001), ACA (p = 0.001), AOD500 (p = 0.001), AOD750 (p < 0.001), TISA500 (p < 0.001) and TISA750 (p < 0.001) were significantly lower in NF1 group. Mean SSL-1 (p = 0.19) and SSL-2 (p = 0.56) measurements were found to be similar between the groups. Mean IT-1 (p < 0.001), IT-2 (p < 0.001) and IT-3 (0.03) were observed to be significantly higher in NF1 group. There was significant correlation between ACD and IT. Also, ACD and IT showed significant associations with the ICA parameters.</p><p><strong>Conclusion: </strong>There was a significantly narrower ICA morphology in NF1 children. SCD was significantly decreased in children with NF1. A significantly thicker iris in NF1 children may offer a possible impact of iris morphology on narrower ICA parameters and SCD.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"In vivo analysis of iridocorneal angle parameters with spectral-domain optical coherence tomography in children with Neurofibromatosis type 1.\",\"authors\":\"Murat Gunay, Ibrahim Mert Kurt, Ugur Yilmaz, Adem Turk, Dilek Uzlu, Busra Kose, Pinar Ozkan Kart, Ali Cansu\",\"doi\":\"10.1038/s41433-025-03840-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To evaluate iridocorneal angle (ICA) parameter measurements with spectral-domain optical coherence tomography (SD-OCT) in children with Neurofibromatosis type 1 (NF1) and to compare them with those in healthy children.</p><p><strong>Methods: </strong>Twenty children with NF1 and 33 age- and sex-matched healthy controls were enroled. All subjects underwent ICA imaging with SD-OCT. Schlemm canal diameter (SCD), anterior chamber angle (ACA), angle opening distance (AOD500 and AOD750), trabecular-iris space area (TISA500 and TISA750) and scleral spur length (SSL) were examined in the temporal sections and measured with customized software. Also, iris thickness (IT) was measured as the distances between the anterior and posterior iris surface, at 1 mm (IT-1), 2 mm (IT-2) and 3 mm (IT-3) from the edge of the pupil.</p><p><strong>Results: </strong>Mean ACD was significantly narrower in NF1 group (p = 0.003). Mean levels of SCD (p < 0.001), ACA (p = 0.001), AOD500 (p = 0.001), AOD750 (p < 0.001), TISA500 (p < 0.001) and TISA750 (p < 0.001) were significantly lower in NF1 group. Mean SSL-1 (p = 0.19) and SSL-2 (p = 0.56) measurements were found to be similar between the groups. Mean IT-1 (p < 0.001), IT-2 (p < 0.001) and IT-3 (0.03) were observed to be significantly higher in NF1 group. There was significant correlation between ACD and IT. Also, ACD and IT showed significant associations with the ICA parameters.</p><p><strong>Conclusion: </strong>There was a significantly narrower ICA morphology in NF1 children. SCD was significantly decreased in children with NF1. A significantly thicker iris in NF1 children may offer a possible impact of iris morphology on narrower ICA parameters and SCD.</p>\",\"PeriodicalId\":12125,\"journal\":{\"name\":\"Eye\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-05-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Eye\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1038/s41433-025-03840-z\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Eye","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1038/s41433-025-03840-z","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
In vivo analysis of iridocorneal angle parameters with spectral-domain optical coherence tomography in children with Neurofibromatosis type 1.
Purpose: To evaluate iridocorneal angle (ICA) parameter measurements with spectral-domain optical coherence tomography (SD-OCT) in children with Neurofibromatosis type 1 (NF1) and to compare them with those in healthy children.
Methods: Twenty children with NF1 and 33 age- and sex-matched healthy controls were enroled. All subjects underwent ICA imaging with SD-OCT. Schlemm canal diameter (SCD), anterior chamber angle (ACA), angle opening distance (AOD500 and AOD750), trabecular-iris space area (TISA500 and TISA750) and scleral spur length (SSL) were examined in the temporal sections and measured with customized software. Also, iris thickness (IT) was measured as the distances between the anterior and posterior iris surface, at 1 mm (IT-1), 2 mm (IT-2) and 3 mm (IT-3) from the edge of the pupil.
Results: Mean ACD was significantly narrower in NF1 group (p = 0.003). Mean levels of SCD (p < 0.001), ACA (p = 0.001), AOD500 (p = 0.001), AOD750 (p < 0.001), TISA500 (p < 0.001) and TISA750 (p < 0.001) were significantly lower in NF1 group. Mean SSL-1 (p = 0.19) and SSL-2 (p = 0.56) measurements were found to be similar between the groups. Mean IT-1 (p < 0.001), IT-2 (p < 0.001) and IT-3 (0.03) were observed to be significantly higher in NF1 group. There was significant correlation between ACD and IT. Also, ACD and IT showed significant associations with the ICA parameters.
Conclusion: There was a significantly narrower ICA morphology in NF1 children. SCD was significantly decreased in children with NF1. A significantly thicker iris in NF1 children may offer a possible impact of iris morphology on narrower ICA parameters and SCD.
期刊介绍：
Eye seeks to provide the international practising ophthalmologist with high quality articles, of academic rigour, on the latest global clinical and laboratory based research. Its core aim is to advance the science and practice of ophthalmology with the latest clinical- and scientific-based research. Whilst principally aimed at the practising clinician, the journal contains material of interest to a wider readership including optometrists, orthoptists, other health care professionals and research workers in all aspects of the field of visual science worldwide. Eye is the official journal of The Royal College of Ophthalmologists.
Eye encourages the submission of original articles covering all aspects of ophthalmology including: external eye disease; oculo-plastic surgery; orbital and lacrimal disease; ocular surface and corneal disorders; paediatric ophthalmology and strabismus; glaucoma; medical and surgical retina; neuro-ophthalmology; cataract and refractive surgery; ocular oncology; ophthalmic pathology; ophthalmic genetics.
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