Eye最新文献

{"title":"Atypical retinitis pigmentosa associated with CERKL mutation.","authors":"Vinit Tanwar, Manasi Tripathi, Varun Gogia","doi":"10.1038/s41433-025-03815-0","DOIUrl":"https://doi.org/10.1038/s41433-025-03815-0","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Afghanistan-Pakistan retinoblastoma \"Silk Road\" referral pathway.","authors":"Mattan Arazi, Jonathan Kfir, Sayed Mansoor Sediqi, Abdul Rahim Majeed, Shabana Chaudhry, Alona Baum, Samina Behjat, Syed Ahmer Hamid, Allen Foster, Ido Didi Fabian","doi":"10.1038/s41433-025-03823-0","DOIUrl":"https://doi.org/10.1038/s41433-025-03823-0","url":null,"abstract":"<p><strong>Background/objectives: </strong>There is no specialist retinoblastoma (Rb) treatment centre in Afghanistan. We aimed to describe the first-year experience and outcome of referring Afghani children with Rb to Pakistan for treatment via the Afghanistan-Pakistan Rb \"Silk-Road\" referral pathway.</p><p><strong>Methods: </strong>A 12-month prospective analysis (January 2023-January 2024) was conducted on children with suspected Rb presenting at National Organisation for Ophthalmic Rehabilitation (NOOR) eye care centres. Online consultations with specialists from the Rb-NET were used to confirm Rb diagnoses, and eligible patients were identified for referral to Rb treatment centres in Pakistan. Data on clinical presentation and outcomes were recorded using a structured Microsoft Excel spreadsheet, which was monitored by the entire team to ensure accuracy and completeness. The primary outcomes included successful transfer to Rb treatment centres in Pakistan and child survival at 1-year follow-up. Secondary outcomes focused on identifying barriers to successful patient transfer.</p><p><strong>Results: </strong>Of the 23 children included in the study, 12/23 (52%) were referred due to leukocoria, 11/23 (48%) were female, 7/23 (30%) presented with bilateral Rb, and none had familial Rb. Overall, 5/23 (22%) children were diagnosed with extraocular disease, and 6/23 (26%) had distant metastases at the time of diagnosis. Only 9/23 (39%) children successfully reached Rb treatment centres in Pakistan. At the last follow-up, 5/23 (22%) children had died, 6/23 (26%) were confirmed alive, and 12/23 (52%) were lost to follow-up. The most common obstacles to patient transfer included difficulty crossing the Afghani/Pakistani border (12/23; 52%) and economic barriers (11/23; 48%) throughout the referral process.</p><p><strong>Conclusions: </strong>This report highlights the immense difficulties in improving child survival from a treatable childhood cancer in a country with poor health care systems. The first-year experience of this referral pathway offers valuable lessons, which can guide the creation of a dedicated Rb treatment centre within Afghanistan.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The aftermath of retinopathy of prematurity blindness.","authors":"Aanchal Sharma","doi":"10.1038/s41433-025-03826-x","DOIUrl":"https://doi.org/10.1038/s41433-025-03826-x","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aflibercept 2 mg biosimilar (Tyalia)-real-world experience from IRAN (ATRIA study).","authors":"Sahar Avadzadeh, Ashish Sharma, Mohammad Mehdi Parvaresh, Khalil Ghasemi Falavarjani","doi":"10.1038/s41433-025-03813-2","DOIUrl":"https://doi.org/10.1038/s41433-025-03813-2","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the early real-world clinical outcomes regarding safety and efficacy after administering the aflibercept 2 mg biosimilar (Tyalia, Cinnagen, Tehran, Iran).</p><p><strong>Methods: </strong>A retrospective, uncontrolled observational study was conducted with a total of 499 Tyalia injections given in 189 eyes of 148 patients for variable indications. All patients were treated with at least one intravitreal injection of Tyalia 2 mg; 102 eyes with neovascular age-related macular degeneration (n-AMD), 67 eyes with diabetic macular oedema (DMO), and 20 eyes with retinal vein occlusion (RVO) associated with macular oedema were included in the analysis.</p><p><strong>Results: </strong>The mean central subfield thickness (CST) of the overall group improved from baseline to the last follow-up from 408.8 ± 155.1 µ to 353.4 ± 142.4 µ (p < 0.001). Best corrected visual acuity was found to be stable in the total cohort. The total number of adverse events (AEs) was (0.4%).</p><p><strong>Conclusions: </strong>The preliminary real-world data from this limited early series suggest that Tyalia appears to have similar clinical efficacy and safety as aflibercept 2 mg innovator across the approved indications. However, long-term data with a larger population are needed to further strengthen the findings of this study.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generative AI in clinical practice: novel qualitative evidence of risk and responsible use of Google's NotebookLM.","authors":"Max Reuter, Maura Philippone, Bond Benton, Laura Dilley","doi":"10.1038/s41433-025-03817-y","DOIUrl":"https://doi.org/10.1038/s41433-025-03817-y","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-altitude retinopathy - a potential model for retinal haemorrhages in suspected shaken baby syndrome.","authors":"Niels Lynøe, Anders Eriksson","doi":"10.1038/s41433-025-03824-z","DOIUrl":"https://doi.org/10.1038/s41433-025-03824-z","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of optic nerve kinking in a cohort of patients with Normal tension glaucoma.","authors":"Achmed Pircher, Jatta Berberat, Luca Remonda, Cynthia J Roberts, Albert Neutzner, Hanspeter E Killer","doi":"10.1038/s41433-025-03608-5","DOIUrl":"10.1038/s41433-025-03608-5","url":null,"abstract":"<p><strong>Objectives: </strong>To report on the incidence of optic nerve kinking in a series of patients diagnosed with normal-tension glaucoma (NTG) compared to an age- and gender matched control group without known optic nerve diseases.</p><p><strong>Subjects and methods: </strong>All patients with NTG who underwent imaging (computed tomography cysternography (CTC) or magnetic resonance imaging (MRI)) of the orbits and cranium between 2012 and 2022 were included, totalling 57 patients (27 females and 30 males; 57 eyes; mean age 69 ± 10 years). 57 age- and gender matched subjects without known optic nerve diseases who underwent MRI of the orbits and cranium served as controls. Radiographic images of the orbits were analysed for the presence of optic nerve kinking.</p><p><strong>Results: </strong>In the axial plane at least one optic nerve kink was found in 49 of 57 (86%) optic nerves in patients with NTG and in 10 of 57 (18%) optic nerves in controls (p < 0.0001) while in the sagittal plane in 28 of 57 (49%) optic nerves in patients with NTG and in 1 of 57 (2%) optic nerves in controls (p < 0.0001) (Fisher's two-tailed exact test).</p><p><strong>Conclusions: </strong>This study demonstrates a high statistically significant incidence of optic nerve kinking in patients with NTG compared to controls without known optic nerve diseases. Its possible role involved in the pathophysiology of NTG needs to be evaluated.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1270-1275"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043848/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender and ethnic diversity in randomised clinical trials in age-related macular degeneration and diabetic macular oedema.","authors":"Farah Ni Ibrahim, Sobha Sivaprasad, Chui Ming Gemmy Cheung","doi":"10.1038/s41433-025-03595-7","DOIUrl":"10.1038/s41433-025-03595-7","url":null,"abstract":"<p><p>In recent years, there has been increasing recognition of the importance of diversity in pivotal randomised clinical trials (RCTs). This is vital to ensure the validity and applicability of the results in the clinical setting. In this review, we aim to assess the inclusion of females and minoritized groups in recent RCTs in age-related macular degeneration (AMD) and diabetic macular oedema (DMO) and explore any potential barriers to their enrolment. Overall, a female predominance was observed among the AMD RCTs while less than half of the study population in DMO trials were females. White participants made up the majority of the study population in both AMD and DMO trials. Gender distribution within minoritized groups has only been reported in a few trials but appears lower than in the white population. This disparity may be attributable to the difference in the prevalence of diseases between these subgroups, as well as social and/ or cultural reasons. Nonetheless, there has been an overall increase in representation of minoritized groups over the past two decades. These observations provide important perspectives to consider when applying clinical trial learnings to clinical settings.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1249-1253"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New frontiers in generative artificial intelligence - enhancing custom GPTs with ophthalmology guidelines.","authors":"Andrea Taloni, Giuseppe Alessio, Giulia Coco, Vincenzo Scorcia, Angeli Christy Yu, Luigi De Rosa, Niccolò Salgari, Massimo Busin, Giuseppe Giannaccare","doi":"10.1038/s41433-025-03746-w","DOIUrl":"10.1038/s41433-025-03746-w","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1235-1237"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-inferiority trials in clinical ophthalmology: a systematic review.","authors":"Dan-Lin Li, Jian-Hua Liu, Xing-Xuan Dong, Carla Lanca, Andrzej Grzybowski, Li-Jun Zhang, Chen-Wei Pan","doi":"10.1038/s41433-025-03819-w","DOIUrl":"https://doi.org/10.1038/s41433-025-03819-w","url":null,"abstract":"<p><strong>Purpose: </strong>To summarize the characteristics and methodology of non-inferiority trials in ophthalmology, aiding researchers in understanding the applications and limitations of such trials in ophthalmic diseases.</p><p><strong>Methods: </strong>PubMed, Web of Science, Embase and Scopus were searched for literature on non-inferiority randomized trials in ophthalmology published between 2000 and November 5 2023. Data on the basic characteristics were extracted and summarized. The Risk of Bias 2's was used to assess the bias risk.</p><p><strong>Results: </strong>A total of 294 papers were included, with 77.6% of the trials conducted in the last 10 years, and more than 2/3 (72.1%) were multicenter studies, and 79.9% were registered on platforms. The majority of trials were applied in the researches of glaucoma, cataract, age macular degeneration, macular edema, dry eye, myopia, or refractive error. Non-inferiority thresholds were reported in 88.4% of the trials. Intent-to-treat analysis was the primary outcome analysis method in only 21.8% of trials, while both intent-to-treat and per-protocol analyses were used in 29.6%. Last observation carried forward method was used to address missing values in 23.5%. However, 56.5% of the articles did not report how missing values were handled, leaving uncertainty regarding whether missing data was considered in the analysis. About 20.7% of the studies were at high risk of bias, mainly due to outcome measures and missing value treatments.</p><p><strong>Conclusion: </strong>Non-inferiority trials are commonly used in ophthalmologic research to assess the effectiveness, safety, cost-effectiveness of treatments or surgical methods, but the quality of implementation and reporting needs to be improved.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}