Eye最新文献

{"title":"MOG-associated optic neuritis in a 4-year-old child presenting with papillary and preretinal haemorrhages.","authors":"Matheus Almeida, Rutika Dodeja","doi":"10.1038/s41433-026-04905-3","DOIUrl":"https://doi.org/10.1038/s41433-026-04905-3","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of port delivery platform with ranibizumab (PDS) for diabetic macular oedema (Pagoda Randomised Clinical Trial).","authors":"Shamika Gune, Mel Rabena, Ashwini Bobbala","doi":"10.1038/s41433-026-04840-3","DOIUrl":"https://doi.org/10.1038/s41433-026-04840-3","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-treatment residual masses in orbital lymphoma: incidence, risk factors, and prognostic impact.","authors":"Yeong A Choi, Min Kyu Yang, Ho-Seok Sa","doi":"10.1038/s41433-026-04918-y","DOIUrl":"https://doi.org/10.1038/s41433-026-04918-y","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to evaluate the incidence and risk factors for residual masses (RMs) following first-line treatment of primary orbital lymphoma (OL) and identify predictors of local recurrence (LR) and systemic relapse (SR) among patients with RMs.</p><p><strong>Methods: </strong>This retrospective study included 100 individuals with OL who received treatment and were followed for over 6 months. Clinical characteristics were reviewed, and treatment responses were assessed at 12 and 24 weeks post-treatment and at the last follow-up. Risk factors for RM presence, persistence, LR, and SR were analysed.</p><p><strong>Results: </strong>The mean age was 57.1 years, with a male predominance (61%) and a median follow-up of 58.2 months. Histological subtypes included extranodal marginal zone lymphoma (EMZL, n = 85), diffuse large B-cell lymphoma (DLBCL, n = 12), and mantle cell lymphoma (MCL, n = 3). Residual masses were identified in 73% of participants at 12 weeks post-treatment. Residual mass presence was significantly associated with tumour size ≥25 mm, AJCC N1/M1 stage, and location in the posterior orbit or with extraocular muscle involvement (each P < 0.05). All LR (n = 19) and SR (n = 8) cases occurred exclusively in patients with RMs. Local recurrence was significantly associated with N1 disease (P < 0.001), while SR correlated with high-grade histological subtypes, such as DLBCL and MCL (P = 0.026).</p><p><strong>Conclusion: </strong>Post-treatment RMs were common in OL, particularly among individuals with advanced-stage, large, or posteriorly located tumours. Among those with RMs, AJCC N1 stage and high-grade histology were independent predictors of relapse. Given the risk of relapse despite standard first-line therapy, intensified treatment and closer surveillance should be considered in this high-risk subgroup.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined limbal dysmaturation and microcyst like epithelial changes with corneal nerve alterations of a novel anti nectin-4-MMAE antibody drug conjugate.","authors":"Marwa Deiri, Rafael Boucher, Cédric Pobel, Jacopo Uliano, Yohann Loriot, Kaissa Ouali, Marc Labetoulle, Antoine Rousseau","doi":"10.1038/s41433-026-04976-2","DOIUrl":"https://doi.org/10.1038/s41433-026-04976-2","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid asymmetric cataract progression in patients following GLP-1 receptor agonist therapy: case series.","authors":"Mahmoud Eissa, Abdullah Hassan, Mohamed Osman, Omar Mehana, Ahmed Elsayed","doi":"10.1038/s41433-026-04971-7","DOIUrl":"https://doi.org/10.1038/s41433-026-04971-7","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normal-tension glaucoma in prolonged open cranial defects: a case series.","authors":"Andrew J Garfield, Saniya S Godil, Irene Gottlob","doi":"10.1038/s41433-026-04969-1","DOIUrl":"https://doi.org/10.1038/s41433-026-04969-1","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Historical controls and modelled costs cannot support first-line amniotic membrane for persistent epithelial defects.","authors":"Jeremy Kassissieh","doi":"10.1038/s41433-026-04946-8","DOIUrl":"https://doi.org/10.1038/s41433-026-04946-8","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning-based prediction of one-year functional and structural outcomes in treatment-naïve DMO after anti-VEGF therapy.","authors":"Lorena Ulla, Jonathan D Oakley, Riccardo Fasana, Daniel B Russakoff, Giovanni Neri, Michele Reibaldi, Enrico Borrelli","doi":"10.1038/s41433-026-04898-z","DOIUrl":"https://doi.org/10.1038/s41433-026-04898-z","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate whether baseline structural optical coherence tomography (OCT) scans contain prognostic information that can be used by deep learning models to predict one-year functional and anatomical outcomes in treatment-naïve diabetic macular oedema (DMO).</p><p><strong>Design: </strong>Retrospective cohort study.</p><p><strong>Participants: </strong>Eighty-seven eyes (74 patients) with treatment-naïve DMO receiving intravitreal anti-VEGF therapy.</p><p><strong>Methods: </strong>Baseline OCT volumes were analysed using a deep learning regression model. The images were homogenised - preprocessed and transformed into a common reference frame - to streamline the learning task. The model predicted 12-month changes in best-corrected visual acuity (BCVA) and central subfield thickness (CST).</p><p><strong>Main outcome measures: </strong>Performance was assessed using 5-fold cross-validation and compared between original and preprocessed datasets. Receiver operating characteristic (ROC) analysis evaluated classification of responders versus non-responders, while occlusion sensitivity analysis identified image regions contributing most to predictions.</p><p><strong>Results: </strong>Mean BCVA improved from 0.40 ± 0.40 to 0.33 ± 0.30 logMAR, and CST decreased from 390.2 ± 77.1 µm to 342.2 ± 76.3 µm (both p < 0.001). Prediction of BCVA change achieved an R² of 0.575, improving to 0.661 after preprocessing. CST prediction improved from R² = 0.447-0.633. Classification performance increased from AUC 0.65 to 0.71 for BCVA response and from 0.93 to 0.97 for CST response. Key predictive regions included the outer retina and retinal pigment epithelium.</p><p><strong>Conclusions: </strong>Deep learning analysis of baseline OCT can predict one-year outcomes in DMO. Image homogenisation enhances performance, and responder identification suggests the potential utility of this approach for prognostic assessment and risk stratification, warranting further validation before clinical implementation.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial palsy buccinator synkinesis-related medial lower eyelid contractions: an under-recognised cause of epiphora treatable with botulinum toxin.","authors":"Simerdip Kaur, Catriona Neville, Mohammad Javed Ali, Raman Malhotra","doi":"10.1038/s41433-026-04968-2","DOIUrl":"https://doi.org/10.1038/s41433-026-04968-2","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent foetal vasculature: Developmental mechanisms, contemporary management and evolving therapeutics.","authors":"Robert H Henderson","doi":"10.1038/s41433-026-04959-3","DOIUrl":"https://doi.org/10.1038/s41433-026-04959-3","url":null,"abstract":"<p><p>Persistent foetal vasculature (PFV) is a spectrum of congenital malformations arising from incomplete regression of the hyaloid-tunica vasculosa lentis complex. Since Reese's original description of persistent hyperplastic primary vitreous and Goldberg's seminal reinterpretation of PFV as a unified developmental spectrum, our understanding has expanded through advances in genetics, imaging, and vitreoretinal surgery. PFV remains one of the most challenging causes of unilateral childhood visual loss. Although modern microsurgical techniques now deliver consistent anatomical success and globe preservation, functional vision is often limited by primary retinal and optic-nerve maldevelopment. This review traces the evolution of PFV management from its embryological basis to current surgical paradigms, integrating evidence from major series and highlighting practical lessons from contemporary vitreoretinal practice.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}