Eye最新文献

{"title":"Understanding the relationship between astigmatism, posterior cornea and corneal thickness: a move to total corneal power.","authors":"Mayank A Nanavaty","doi":"10.1038/s41433-025-03742-0","DOIUrl":"10.1038/s41433-025-03742-0","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1437-1439"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generative AI in clinical practice: novel qualitative evidence of risk and responsible use of Google's NotebookLM.","authors":"Max Reuter, Maura Philippone, Bond Benton, Laura Dilley","doi":"10.1038/s41433-025-03817-y","DOIUrl":"10.1038/s41433-025-03817-y","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1650-1652"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of immediate sequential bilateral cataract surgeries (ISBCS) performed by trainees vs consultants: a two-armed cohort study.","authors":"Rajesh Deshmukh, Mohsan Malik, Sam Myers, Mumta Kanda, Alasdair Warwick, Lucy Barker, Alex Ionides","doi":"10.1038/s41433-025-03739-9","DOIUrl":"10.1038/s41433-025-03739-9","url":null,"abstract":"<p><strong>Purpose: </strong>To compare outcomes of Immediate Sequential Bilateral Cataract Surgeries (ISBCS) performed by resident doctors versus consultant ophthalmologists at Moorfields Eye Hospital and its satellite centres.</p><p><strong>Methods: </strong>The study reviewed ISBCS performed by phacoemulsification and intraocular lens implant, comparing resident ophthalmologists (Gr1) and consultant ophthalmologists (Gr2). Outcomes examined included complications, refraction (spherical equivalent (SE) > 0.5D and >1.0D from predicted target refraction), and uncorrected distance visual acuity (UDVA logMAR) at three months post-ISBCS.</p><p><strong>Results: </strong>The study included 553 eyes in Gr1 and 687 in Gr2. UDVA post-surgery was similar in both groups (P = 0.26). Intra- and postoperative complications were comparable between groups [RR = 1.88 (95% CI 0.8; 4.2) P = 0.13]. We found no statistically significant difference in refractive outcomes between groups (Gr1 [-0.12 D (IQR -0.5; -0.25)] and Gr2 [-0.25D (IQR -0.63; -0.13)] (P = 0.08)). Similarly, no difference was found in patients with >1.0D SE predicted refractive outcome between groups (6% of Gr1 and 3.9% of Gr2 (P = 0.142)). The grade of the surgeon, PCR risk, and predicted refraction were not significant predictors of postoperative refractive error (SE > 0.5D).</p><p><strong>Conclusions: </strong>ISBCS outcomes by resident ophthalmologists were comparable to those by consultants. Given the broader fiscal and workforce challenges, our findings advocate that resident ophthalmologists performing ISBCS under supervision may enhance training opportunities.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1724-1729"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diameter of cystoid spaces and choroidal hypertransmission as novel prognostic biomarkers in myopic foveoschisis.","authors":"Emanuele Crincoli, Alfonso Savastano, Maria Cristina Savastano, Clara Rizzo, Raphael Kilian, Umberto De Vico, Ilaria Biagini, Matteo Maria Carlà, Federico Giannuzzi, Stanislao Rizzo","doi":"10.1038/s41433-025-03738-w","DOIUrl":"10.1038/s41433-025-03738-w","url":null,"abstract":"<p><strong>Purpose: </strong>To analyse optical coherence tomography (OCT) biomarkers of anatomical and functional success in myopic foveoschisis (MF) (stage I and II of ATN classification) undergoing pars plana vitrectomy (PPV).</p><p><strong>Materials and methods: </strong>Isolated MF cases who underwent PPV showing preoperative optical coherence tomography (OCT)-documented integrity of the foveal ellipsoid zone (EZ) and retinal pigmented epithelium (RPE) were included. Availability of good quality preoperative and 1-year-postoperative OCT acquisitions was also mandatory for inclusion. Anatomical success was defined as persistence of <20% of preoperative cystoid spaces within the parafoveal region and preservation of the foveal EZ and RPE. Functional success was defined as postoperative improvement of at least 10 ETDRS letters.</p><p><strong>Results: </strong>Anatomical success was obtained in 86.1% cases (31/36). A significantly higher prevalence of preoperative choroidal hypertransmission (CH) with preserved EZ and RPE was detected in the anatomical failure group. Functional success was reported in 72.2% of cases. A larger diameter of preoperative foveal cysts and the presence of a cotton ball sign were associated with a worse functional outcome. Dome shaped macula (DMS) was associated to a good anatomical and functional outcome.</p><p><strong>Conclusions: </strong>Our retrospective analysis highlighted that the preoperative presence of a foveal CH with preserved foveal EZ and RPE might be predictive a postoperative anatomical and functional failure in MF surgery. By contrast, a larger diameter of foveal cysts might be associated to functional failure despite anatomical success, while DMS might be a predictor of good prognosis. Assessment of the described biomarkers on a larger prospective cohort is needed to validate our findings.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1781-1786"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Descemet membrane endothelial keratoplasty with or without overnight admission.","authors":"Giulia Coco, Luca Pagano, Alfredo Borgia, Mahmoud Ahmed, Davide Tucci, Kunal A Gadhvi, Stephen B Kaye, Vito Romano","doi":"10.1038/s41433-025-03754-w","DOIUrl":"10.1038/s41433-025-03754-w","url":null,"abstract":"<p><strong>Objective: </strong>To compare visual outcomes and show postoperative complication rates of Descemet Membrane Endothelial Keratoplasty (DMEK) with or without overnight admission.</p><p><strong>Methods: </strong>Retrospective analysis of DMEK surgeries performed at the Royal Liverpool University Hospital from 2018 to 2023. Data on demographics, surgical details, intraoperative and postoperative complications and admission type were collected. Visual outcomes and complication rates of surgeries with or without overnight admission were evaluated.</p><p><strong>Results: </strong>344 eyes were included with mean patients' age of 72.1 ± 9.7 years (range 37.4-96.6 years). After surgery, 61.3% of patients (n = 211) were hospital-admitted for a one-night stay while 38.7% (n = 133) were home-discharged on the same day. Intraoperative complications occurred in 8.7% of patients and postoperative complications in 5.8%, with no difference with or without overnight admission (p = 0.308 and p = 0.412, respectively). There was no difference in the improvement in visual acuity (0.43 ± 0.6 and 0.45 ± 0.6 logMAR; range: -1.82; +2.38 logMAR) between both groups (p = 0.984), and no difference was found in postoperative rebubbling rate between both groups (30.8% in hospital-admitted and 31.6% in home-discharged; p = 0.926). Multivariate logistic regression showed no association between overnight admission and DMEK rebubbling rate (p = 0.555). However, postoperative complications, triple procedure and recipient age were all significant factors increasing DMEK rebubbling requirement (p < 0.05). Home-discharged patients had a risk ratio of 1.03 (95% CI 0.74-1.41; p = 0.926) for rebubbling and 0.68 (95% CI 0.28-1.372; p = 0.412) for postoperative complications compared to their hospital-admitted counterpart.</p><p><strong>Conclusions: </strong>Visual outcomes and postoperative complications did not show any significant difference in DMEK surgeries with or without overnight admission.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1831-1836"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The aftermath of retinopathy of prematurity blindness.","authors":"Aanchal Sharma","doi":"10.1038/s41433-025-03826-x","DOIUrl":"10.1038/s41433-025-03826-x","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1870"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updates on novel and traditional OCT and OCTA biomarkers in nAMD.","authors":"Emanuele Crincoli, Maria Cristina Parravano, Riccardo Sacconi, Eliana Costanzo, Maria Sole Polito, Lorenzo Ferro Desideri, Giuseppe Querques","doi":"10.1038/s41433-025-03801-6","DOIUrl":"10.1038/s41433-025-03801-6","url":null,"abstract":"<p><p>Predictivity of optical coherence tomography (OCT) examination for the development of neovascular age-related macular degeneration (nAMD) was demonstrated to be superior compared to other methods, suggesting it as an elective method for screening purposes. Moreover, OCT and OCT angiography (OCTA) have enabled us to provide accurate prognostic information to nAMD patients. Along with well-known prognostic biomarkers, such as the presence of reticular pseudodrusen, the volume of the pigment epithelial detachment (PED), subretinal fluid (SRF), intraretinal fluid (IRF) and hyperreflective foci (HRF), emerging parameters show promising results and may allow a further refinement of prediction and customization of treatment and follow up strategies. This review of the literature discusses the main OCT and OCTA biomarkers reported in literature for nAMD, with a special focus on recent updates on the subject. Future perspectives of clinical applications include the development of artificial intelligence models considering all the described biomarkers to allow automatic and detailed characterization of each lesion based on imaging information.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1662-1672"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130492/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ophthalmology during conflict: a vitreoretinal surgeon's journey in Gaza.","authors":"Omar Hawwa, Saeed Azizi, Mohammed MSallam, Mohamed Tawfik","doi":"10.1038/s41433-025-03802-5","DOIUrl":"10.1038/s41433-025-03802-5","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1657-1658"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of fundus changes in healthy school-aged children and adolescents aged 5-19 years in Beijing.","authors":"Haowen Li, Jingying Xiu, Wei Zhang, Jie Xu, Yang Li, Wenbin Wei","doi":"10.1038/s41433-025-03711-7","DOIUrl":"10.1038/s41433-025-03711-7","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate and analyse the epidemiological characteristics of fundus changes among school-aged children, and to explore its correlation with myopia.</p><p><strong>Methods: </strong>School-aged children from 20 schools in Beijing were screened under cooperation between Beijing Tongren Hospital and Beijing Daxing District Education Commission from September 2022 to March 2023. Uncorrected non-dilated visual acuity and refraction were examined. Fundus photographs of both eyes were evaluated by skilled clinicians. The differences in fundus changes among demographic characteristics were compared.</p><p><strong>Results: </strong>A total of 15,031 participants (30,062 eyes) from 20 schools were included, including 14 elementary schools and 6 secondary schools. The prevalence of fundus changes was 3.3%, 5.9%, and 6.2% for elementary schools, junior and senior high schools, respectively. The top five fundus changes comprised of myopia-related fundus changes (2.0%), physiologic enlarged cup (1.2%), suspected glaucoma (0.3%), myelinated nerve fibres (0.1%), and papillomacular bundle defect (PMBD) (0.1%). Males exhibited a 7.627 and 1.388 times higher risk of developing PMBD and physiological enlarged cup (p < 0.01, respectively). Eyes with myopia-related fundus changes and suspected glaucoma exhibited larger interpupillary distance, longer eye axis, worse visual acuity and lower spherical equivalent.</p><p><strong>Conclusions: </strong>The prevalence of fundus changes varies with school ages, gender, and myopia status. The prevalence of myopia-related fundus changes, suspected glaucoma, and other retinopathy or optic neuropathy escalates with increasing age and the severity of myopia. The pathological myopia is scarce in children. Male gender is a risk factor for PMBD and is also modestly associated with physiological enlarged cup.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1624-1630"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Botulinum toxin A effective in treating dry eye disease? A systematic review and meta-analysis.","authors":"Kai-Yang Chen, Hoi-Chun Chan, Chi-Ming Chan","doi":"10.1038/s41433-025-03790-6","DOIUrl":"10.1038/s41433-025-03790-6","url":null,"abstract":"<p><p>Dry eye disease (DED) is a complex condition characterized by tear film instability, inflammation, and neurosensory abnormalities. The efficacy of Botulinum toxin A (BTX-A) in treating DED is unknown. A systematic search was conducted across PubMed, the Cochrane Library, Scopus, Web of Science, and Embase databases for studies published until December 2024. Inclusion criteria encompassed randomized controlled trials (RCTs) and non-RCTs examining BTX-A's effects on DED, with TBUT, Schirmer test scores, tear meniscus height (TMH), and OSDI as primary outcomes. Data were synthesized using fixed and random-effects models, accounting for heterogeneity. Fourteen studies (total n = 634 patients) were included. This meta-analysis evaluates the effectiveness of BTX-A in improving outcomes for DED. In 10 studies with 513 participants, BTX-A significantly improved TBUT by 1.79 s (95% CI: 1.48 to 2.10, p < 0.00001), Schirmer test scores by 3.72 mm (95% CI: 3.50 to 3.95, p < 0.00001), and OSDI scores by -7.51 (95% CI: -10.76 to -4.26, p < 0.00001). TMH increased by 0.10 mm (95% CI: 0.08 to 0.11, p < 0.00001). This meta-analysis demonstrates that BTX-A effectively improves clinical outcomes in DED. Post-treatment, TBUT increased by 1.79 s, Schirmer test scores improved by 3.72 mm, OSDI scores decreased by -7.51 points, and TMH increased by 0.10 mm, reflecting enhanced tear stability, production, and symptom relief. These findings support the use of BTX-A in clinical practice as a promising treatment for DED.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1457-1464"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}