Eye最新文献_第3页

Oestrus ovis larvae on the cornea. 发情的卵在角膜上。

IF 2.8 3区医学

Eye Pub Date : 2025-01-20 DOI: 10.1038/s41433-025-03609-4

Bixia Wei, Lin Ding, Tao Shen

引用次数: 0

Incidence of optic nerve kinking in a cohort of patients with Normal tension glaucoma. 正常张力性青光眼患者视神经扭结的发生率。

IF 2.8 3区医学

Eye Pub Date : 2025-01-18 DOI: 10.1038/s41433-025-03608-5

Achmed Pircher, Jatta Berberat, Luca Remonda, Cynthia J Roberts, Albert Neutzner, Hanspeter E Killer

{"title":"Incidence of optic nerve kinking in a cohort of patients with Normal tension glaucoma.","authors":"Achmed Pircher, Jatta Berberat, Luca Remonda, Cynthia J Roberts, Albert Neutzner, Hanspeter E Killer","doi":"10.1038/s41433-025-03608-5","DOIUrl":"https://doi.org/10.1038/s41433-025-03608-5","url":null,"abstract":"Objectives: To report on the incidence of optic nerve kinking in a series of patients diagnosed with normal-tension glaucoma (NTG) compared to an age- and gender matched control group without known optic nerve diseases.Subjects and methods: All patients with NTG who underwent imaging (computed tomography cysternography (CTC) or magnetic resonance imaging (MRI)) of the orbits and cranium between 2012 and 2022 were included, totalling 57 patients (27 females and 30 males; 57 eyes; mean age 69 ± 10 years). 57 age- and gender matched subjects without known optic nerve diseases who underwent MRI of the orbits and cranium served as controls. Radiographic images of the orbits were analysed for the presence of optic nerve kinking.Results: In the axial plane at least one optic nerve kink was found in 49 of 57 (86%) optic nerves in patients with NTG and in 10 of 57 (18%) optic nerves in controls (p < 0.0001) while in the sagittal plane in 28 of 57 (49%) optic nerves in patients with NTG and in 1 of 57 (2%) optic nerves in controls (p < 0.0001) (Fisher's two-tailed exact test).Conclusions: This study demonstrates a high statistically significant incidence of optic nerve kinking in patients with NTG compared to controls without known optic nerve diseases. Its possible role involved in the pathophysiology of NTG needs to be evaluated.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The community optometry workforce in Scotland: supporting sustainable eye care delivery. 苏格兰社区验光人员：支持可持续的眼科保健服务。

IF 2.8 3区医学

Eye Pub Date : 2025-01-18 DOI: 10.1038/s41433-024-03573-5

Helen Court, Jacquie Dougall, Janet Pooley

{"title":"The community optometry workforce in Scotland: supporting sustainable eye care delivery.","authors":"Helen Court, Jacquie Dougall, Janet Pooley","doi":"10.1038/s41433-024-03573-5","DOIUrl":"10.1038/s41433-024-03573-5","url":null,"abstract":"Background: In early 2024, NHS Scotland published community optometrist workforce and activity data at a national level for the first time in the UK. These data are now over two years old, and anecdotal reports suggest changes amongst optometrists' work-patterns post-pandemic. To identify if that data continues to be reflective of the community optometrist workforce, the aim of this paper is to provide equivalent data for 2022 and 2023.Methods: Anonymised information about the active community optometrist workforce was extracted from routinely collected eye examination claim data, for periods 29th Aug-4th Dec 2022 and 28th Aug-3rd Dec 2023, and compared to equivalent published data (2019/2020). Workforce information included optometrist headcount, working days per week and independent prescribing optometrist activity.Results: During 2022 and 2023, n = 1451 and n = 1489 community optometrists were active respectively, with independent prescribing workforce activity increasing from 24.1% to 26.6%. During 2023, 61.3% and 34.9% of the workforce delivered eye examinations an average of 4 and 5 or more days per week respectively. Since 2019, the proportion of community optometrists who were female increased by 2.9% and over half the active workforce remained <40 years old.Conclusions: The data in this paper indicates a growing, active community optometrist workforce, including an increasing number of active independent prescribers. Working patterns are stabilising after an initial shift towards more part-time working after the COVID-19 pandemic. As well as supporting workforce planning and service design in NHS Scotland, these findings may help provide insight into the wider UK optometrist workforce.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SD-OCT-histopathologic correlation in Schnabel's cavernous optic nerve atrophy. Schnabel海绵状视神经萎缩的sd - oct病理相关性。

IF 2.8 3区医学

Eye Pub Date : 2025-01-18 DOI: 10.1038/s41433-025-03603-w

C Weber, K Mercieca, J M Weller, L M Bulirsch, T Ach, F G Holz, K U Loeffler, M C Herwig-Carl

{"title":"SD-OCT-histopathologic correlation in Schnabel's cavernous optic nerve atrophy.","authors":"C Weber, K Mercieca, J M Weller, L M Bulirsch, T Ach, F G Holz, K U Loeffler, M C Herwig-Carl","doi":"10.1038/s41433-025-03603-w","DOIUrl":"https://doi.org/10.1038/s41433-025-03603-w","url":null,"abstract":"Background: Until now, Schnabel's cavernous optic nerve atrophy (SCONA) has solely been a histopathological diagnosis exhibiting variable degrees of optic nerve (ON) atrophy with characteristic cavernous spaces filled with acid mucopolysaccharides. We report the first correlation of histopathologic findings with spectral domain-optical coherence tomography (SD-OCT) imaging in SCONA.Methods: We examined the eye of an index patient with histopathologically identified SCONA who had undergone multimodal imaging before enucleation for iris ring melanoma. The extent of SCONA in the index patient and three other enucleated eyes with SCONA were determined histopathologically. The histopathological findings of our index patient were correlated with in vivo SD-OCT images before enucleation and compared to representative images from eyes with a normal versus glaucomatous optic disc.Results: Histopathologic examination of our index patient showed a pre- and intralaminar extension of SCONA. Atrophy of the inner retinal layers was observed corresponding to the extent of SCONA. Correlation with SD-OCT showed small intralaminar hyporeflective pseudocysts which were detected in multiple scans corresponding to the histologically affected areas. These changes were neither visible in scans of patients with glaucomatous atrophy nor those with a normal ON.Conclusions: We present the first correlation of clinical and pathological findings in SCONA and were able to identify distinct SD-OCT characteristics for this condition. These findings may help to detect SCONA in vivo and to study this rare entity clinically with regard to its clinical course, risk factors, and pathogenesis. However, more cases of SCONA are needed to confirm our findings.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topography-guided, patterned, customized corneal crosslinking for non-invasive astigmatism correction. 用于非侵入性散光矫正的地形图引导、图案化、定制化角膜交联。

IF 2.8 3区医学

Eye Pub Date : 2025-01-18 DOI: 10.1038/s41433-025-03602-x

Zixin Fan, Xinyi Jiang, Suwen Zhao, Ningxin Dou, Fei Yao, Shaochong Zhang, Gangpei Cai, Yang Li, Yiheng Wu, Weidong He, Guoming Zhang, Shengli Mi

{"title":"Topography-guided, patterned, customized corneal crosslinking for non-invasive astigmatism correction.","authors":"Zixin Fan, Xinyi Jiang, Suwen Zhao, Ningxin Dou, Fei Yao, Shaochong Zhang, Gangpei Cai, Yang Li, Yiheng Wu, Weidong He, Guoming Zhang, Shengli Mi","doi":"10.1038/s41433-025-03602-x","DOIUrl":"https://doi.org/10.1038/s41433-025-03602-x","url":null,"abstract":"Objectives: To propose and evaluate a novel, non-invasive approach for enduring corneal astigmatism correction based on topography-guided, patterned, customized riboflavin-ultraviolet A corneal collagen crosslinking (CXL).Methods: Astigmatism was modelled on both eyes of rabbits. A randomly selected eye of each rabbit was treated by the proposed CXL procedure with another eye as control. The proposed procedure was performed by a self-built intelligent platform through delivering ultraviolet A lattice in a refined and patterned manner, based on pre-operative corneal topography. The long-term effectiveness, stability, and safety were investigated for 180 days, with topographic measurements, anterior segment optical coherence tomography (AS-OCT), and in vivo corneal confocal microscopy (IVCM).Results: Spatially selective demarcation lines in AS-OCT images and trabecular patterned hyperdense structure with abundant needle-like processes in IVCM images were detected in the CXL eyes, revealing spatially selective crosslinking. Reductions of astigmatic magnitude (in the steep axis: 0.46 ± 0.28 vs. 2.15 ± 0.58 dioptres, P < 0.001) and high order aberration (0.38 ± 0.18 vs. 0.59 ± 0.19, P = 0.009) with increase of visual strehl ratio (0.21 ± 0.06 vs. 0.13 ± 0.03, P < 0.001) were found in the CXL eyes after CXL and maintained for 180 days, compared to inconspicuous changes in the control eyes. No obvious opacity and inflammation were observed in the CXL eyes, and transient loss of endothelial cells in the treated area was recovered in the subsequent visit.Conclusions: The proposed novel, non-invasive approach safely fulfilled corneal astigmatism correction with visual quality improvement as well as a decrease in high-order aberration.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A multifactorial, evidence-based analysis of pathophysiology in Spaceflight Associated Neuro-Ocular Syndrome (SANS). 航天相关神经-眼综合征（SANS）病理生理的多因素、循证分析

IF 2.8 3区医学

Eye Pub Date : 2025-01-18 DOI: 10.1038/s41433-025-03618-3

Laura A Galdamez, Thomas H Mader, Joshua Ong, Cihan Mehmet Kadipasaoglu, Andrew G Lee

{"title":"A multifactorial, evidence-based analysis of pathophysiology in Spaceflight Associated Neuro-Ocular Syndrome (SANS).","authors":"Laura A Galdamez, Thomas H Mader, Joshua Ong, Cihan Mehmet Kadipasaoglu, Andrew G Lee","doi":"10.1038/s41433-025-03618-3","DOIUrl":"https://doi.org/10.1038/s41433-025-03618-3","url":null,"abstract":"The National Aeronautics and Space Administration (NASA) in the United States has been studying a fascinating and unique constellation of neuro-ophthalmic findings collectively known as Spaceflight Associated Neuro-Ocular Syndrome (SANS). SANS is unique to the space environment of microgravity and produces novel physiological and pathological findings that have no direct terrestrial equivalent. The neuro-ophthalmic phenomenon is a major physiologic barrier to future planetary spaceflight. The underlying pathophysiology of SANS remains ill-defined, but since its initial report in 2011, several hypotheses have been proposed including increased intracranial pressure, cerebral venous congestion and glymphatic stasis, compartmentalization of CSF within the orbital nerve sheath sub-arachnoid space (SAS), upward brain shift, inflammation, disrupted axoplasmic transport, and radiation exposure. These aetiologies may not be mutually exclusive and may be interconnected, leading to an integrative, multifactorial aetiology of SANS. This paper critically analyses the various hypotheses of this neuro-ophthalmic phenomenon and the connections between the physiologic and anatomical evidence-based changes observed in spaceflight and terrestrial analogues. Continued prospective, longitudinal study and development of practical countermeasures for SANS will be necessary for future human spaceflight missions including the mission to Mars.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fundus vascular arcades angle reflects choroidal thickness in highly myopic children and adolescents. 高度近视儿童及青少年眼底血管拱廊角反映脉络膜厚度。

IF 2.8 3区医学

Eye Pub Date : 2025-01-18 DOI: 10.1038/s41433-025-03604-9

Wei Gong, Bo Zhang, Dengji Zhou, Saiguang Ling, Jinliuxing Yang, Jun Chen, Jingjing Wang, Xun Xu, Xiangui He, Wei Gao

{"title":"Fundus vascular arcades angle reflects choroidal thickness in highly myopic children and adolescents.","authors":"Wei Gong, Bo Zhang, Dengji Zhou, Saiguang Ling, Jinliuxing Yang, Jun Chen, Jingjing Wang, Xun Xu, Xiangui He, Wei Gao","doi":"10.1038/s41433-025-03604-9","DOIUrl":"https://doi.org/10.1038/s41433-025-03604-9","url":null,"abstract":"Objectives: To identify the role of fundus vascular arcades angle (VAA) in reflecting choroidal thickness (ChT) of highly myopic children and adolescents.Methods: Participants aged 5 to 18 yrs with high myopia (spherical equivalent, SE ≤ -5.0 D) were enrolled and followed up for one year from the Shanghai Child and Adolescent Large-scale Eye Study. The VAA in the range of one papillary diameter (PD) as well as 2PD away from the central point of optic disc was recognized and measured by artificial intelligence from fundus photographs.Results: Finally, 277 highly myopic participants were included in the analysis. The mean VAA (1PD) was 128.38 ± 9.56°, and the mean VAA (2PD) was 110.25 ± 11.97°. For those with larger VAA, the choroidal thickness around macula (mChT) or papillary (pChT) was thicker (P for trend < 0.05). After adjusting for age and gender, thinner ChT was independently associated with smaller VAA (P < 0.001). For those with more decrease of VAA, the thinning of ChT was more remarkable (P < 0.05). In the regression analysis, more change of pChT was independently associated with more change of VAA (P < 0.01). After adjusting for other related parameters, 1°change of VAA (1PD) or VAA (2PD) accounted for 0.855 mm or 0.719 mm change of pChT.Conclusions: Fundus VAA was closely associated with choroidal thickness in highly myopic paediatric population. It could serve as an alternative indicator of choroid thickness in the fundus screening for evaluating the risk of pathological changes of high myopia.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extrapulmonry Tuberculosis in a Child Presenting as an Eyelid Cyst. 以眼睑囊肿为表现的儿童肺外结核。

IF 2.8 3区医学

Eye Pub Date : 2025-01-17 DOI: 10.1038/s41433-025-03611-w

Prabrisha Banerjee, Kirthi Koka, Bipasha Mukherjee

引用次数: 0

Acute idiopathic frosted branch angiitis. 急性特发性霜支血管炎。

IF 2.8 3区医学

Eye Pub Date : 2025-01-17 DOI: 10.1038/s41433-025-03606-7

Bangtao Yao, Yinling Wu, Yuhua Ding

引用次数: 0

Hardy-Rand-Rittler colour vision testing in cone and cone-rod dystrophies: correlation with structural and functional outcome measures. 锥体和锥杆营养不良患者的Hardy-Rand-Rittler色觉测试：与结构和功能结果测量的相关性。

IF 2.8 3区医学

Eye Pub Date : 2025-01-16 DOI: 10.1038/s41433-024-03584-2

Brindhan Tharmarajah, Elisa E Cornish, Jonathan Nguyen, Elizabeth Barnes, Kate E Leahy, Anagha Vaze, Robyn V Jamieson, John R Grigg

{"title":"Hardy-Rand-Rittler colour vision testing in cone and cone-rod dystrophies: correlation with structural and functional outcome measures.","authors":"Brindhan Tharmarajah, Elisa E Cornish, Jonathan Nguyen, Elizabeth Barnes, Kate E Leahy, Anagha Vaze, Robyn V Jamieson, John R Grigg","doi":"10.1038/s41433-024-03584-2","DOIUrl":"https://doi.org/10.1038/s41433-024-03584-2","url":null,"abstract":"Purpose: To determine how Hardy-Rand-Rittler (HRR) colour vision testing correlates with visual functional and structural assessments in Cone and Cone-Rod Dystrophy.Methods: Thirty-four Cone and 69 Cone-Rod Dystrophy patients diagnosed by electroretinography (ERG) at the Save Sight Institute in Sydney were included in a retrospective analysis. Each patient's HRR colour vision test scores were compared with markers of cone and rod system function including visual acuity (VA), ERG responses, changes on Spectral Domain Optical Coherence Tomography (OCT) and Fundus Autofluorescence.Results: The number of plates identified on HRR testing correlated with logMAR best-corrected distance VA; r(101) = -0.49, p < 0.0001. HRR scores correlated with markers of cone and macula function including OCT Ellipsoid Zone Gap Width, Central Macular and Outer Nuclear Layer Thickness, Full Field ERG 30 Hz flicker amplitudes, light adapted 3.0 b-wave amplitudes and Pattern ERG 15- and 30-degree p50 amplitudes.Conclusion: HRR colour vision testing correlates with structural and functional measures in Cone and Cone-Rod Dystrophy. HRR colour vision testing provides a simple clinic-based option to monitor disease changes in Cone and Cone-Rod Dystrophy patients, especially when ERG testing is not available.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0