Eye最新文献

{"title":"Comparative carbon footprinting study of reusable vs. disposable instruments in cataract surgery.","authors":"Eleanor McCance, Ingeborg Steinbach, Daniel S Morris","doi":"10.1038/s41433-025-03656-x","DOIUrl":"10.1038/s41433-025-03656-x","url":null,"abstract":"<p><strong>Background: </strong>Theatre activity is a major source of hospital waste, accounting for 21-30% of total output, and is 3-6 times more energy-intensive than any other hospital department. Cataract remains the leading cause of blindness worldwide, and cataract surgery is the most commonly performed surgical procedure worldwide, but to date has received little analysis in this field. The aim of this study was to evaluate the carbon impact of streamlining single-use packs, and transitioning from single-use items, to reusable equivalents in cataract surgery.</p><p><strong>Methods: </strong>A focus group and prospective audit was carried out to identify single-use pack items for streamlining. A bottom-up, process-based carbon footprint analysis was conducted of single-use items and reusable alternatives using activity data provided by the suppliers and greenhouse gas (GHG) conversion factors from the UK Government GHG Conversion Factors for Company Reporting database.</p><p><strong>Results: </strong>Total carbon savings from streamlining was 935 kgCO2e/year, and switching, was 309 kgCO2e/year. Single-use items had a 27 times greater carbon footprint than reusable equivalents (322 kgCO2 vs. 12 kgCO2e respectively). A net carbon saving was achieved from 19 or more re-uses of the reusable items compared to single-use equivalents.</p><p><strong>Conclusions: </strong>This study provides evidence of carbon emissions savings both from streamlining disposable instruments in cataract surgical packs, and from switching from single-use to reusable instruments. Mitigation strategies targeting hotspots in resource intensive areas will be an important aspect of reducing the climate burden of surgery. Change in practice and policy is required in all surgical specialities to realize net zero carbon healthcare.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1481-1485"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seeing the unseen: uncovering health-related social needs through universal screening at an academic ophthalmology practice.","authors":"Natasha Mayer, Julie Cassidy, Lauren M Wasser, Peggy J Liu, Andrew M Williams","doi":"10.1038/s41433-025-03690-9","DOIUrl":"10.1038/s41433-025-03690-9","url":null,"abstract":"<p><strong>Background: </strong>Health-related social needs (HRSN), or unmet conditions that are important to maintain health (such as finances and transportation), contribute to vision health disparities. The purpose of this study is to identify the unmet HRSN of ophthalmology clinic patients.</p><p><strong>Methods: </strong>This retrospective, cross-sectional study examined HRSN survey results from adult patients who checked in for a clinic visit at a tertiary academic eye centre from April 28, 2022, to March 31, 2023. Demographics and visual acuity were extracted from the electronic health record, and their reported HRSNs were evaluated using binary logistic regression.</p><p><strong>Results: </strong>Of 1413 patients who completed the survey, 194 (13.7%) screened positive for at least one HRSN. The most frequently reported need was food insecurity (99/1303, 7.6%), followed by transportation (68/1340, 5.1%), housing instability (63/1305, 4.8%), financial insecurity (46/1293, 3.6%), and homelessness (10/1330, 0.8%). Patients with at least one reported HRSN were more likely to be Black compared to White (OR 4.03, 95% CI: 2.71-5.96), female compared to male (OR 1.88, 95% CI: 1.34-2.62), and younger than 65 years of age compared to 65 to 75 years (OR 2.35, 95% CI: 1.68-3.37) or older than 75 years (OR 4.62, 95% CI: 2.54-8.16). Presence of at least one HRSN was associated with visual impairment, with greater odds of best-corrected visual acuity worse than 20/40 in the group with HRSN compared to without HRSN (OR 1.55, 95% CI: 1.09-2.19).</p><p><strong>Conclusion: </strong>Integrating a screening questionnaire in ophthalmology clinics can uncover unaddressed HRSN, enabling resource allocation to mitigate vision health disparities.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1501-1507"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extended phenotypic spectrum of benign yellow dot maculopathy.","authors":"Peter Kiraly, Johannes Birtel, Ariel Y Ong, Claire Ruan, M Dominik Fischer, Peter Charbel Issa","doi":"10.1038/s41433-024-03590-4","DOIUrl":"10.1038/s41433-024-03590-4","url":null,"abstract":"<p><strong>Background: </strong>To present the morphological and functional characteristics of individuals with benign yellow dot maculopathy (BYDM).</p><p><strong>Methods: </strong>Assessments included ocular examinations, best-corrected visual acuity (BCVA) testing, optical coherence tomography (OCT), blue-light fundus autofluorescence (BAF), and near-infrared autofluorescence (NIR-AF). First degree family members were also examined whenever available.</p><p><strong>Results: </strong>25 individuals with BYDM (15 females, 10 males) from 19 unrelated families with a median age at first presentation of 37 years (range, 4-54 years) were included in the study. The 19 index patients were referred for assessment of early-onset drusen (n = 10), macular dystrophy (n = 6), or an unrelated ocular condition (n = 3). Clinical examination of 15 first-degree family members of 8 probands revealed vertical transmission in 6 relatives. After excluding 6 patients with other ocular pathologies, BCVA was 20/25 or better in all patients. Fundoscopically, all patients had yellow dots in the macular area, extending to the vascular arcades in 19 and beyond in 11 individuals. Hyper-autofluorescent dots on BAF topographical matched the dots seen on fundoscopy, while hypo-autofluorescent dots were noted on NIR-AF. OCT revealed no abnormalities in 14 cases, but mild ellipsoid zone irregularities were observed in 11. No morphological or functional progression was noted in 15 individuals over an average follow-up period of 3.6 years.</p><p><strong>Conclusion: </strong>BYDM may present with a mild phenotype with yellow dots extending to the vascular arcades and beyond, suggesting it could be more common than previously reported. Recognizing this phenotype may reduce unnecessary investigations and follow-ups. Yellow dots show hypo-autofluorescence on NIR-AF and there is no morphological or functional progression.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1547-1552"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of pediatric and adult optic neuritis in the United States from 2016 to 2023.","authors":"Nadia J Abbass, Jacqueline K Shaia, Priya Shukla, Devon Cohen, David C Kaelber, Katherine E Talcott, Rishi P Singh","doi":"10.1038/s41433-025-03683-8","DOIUrl":"10.1038/s41433-025-03683-8","url":null,"abstract":"<p><strong>Background/objectives: </strong>Data on the prevalence of optic neuritis (ON) is limited with reported rates between 5.5 and 115.3 per 100,000. The US data is even more limited with the largest study performed in a single county, finding a prevalence of 115.3. This study aims to fill the gap in US data on ON.</p><p><strong>Methods: </strong>This (2016-2023) cross-sectional study included patients with ICD-10 codes of retrobulbar neuritis, other ON, unspecified ON, and excluded those with optic papillitis, nutritional optic neuropathy, toxic optic neuropathy. Data was collected through a series of queries in a large platform (TriNetX, LLC) containing EHR data from over 113 million patients.</p><p><strong>Results: </strong>In 2023, the prevalence of ON was 51.6 per 100,000 people in the overall population. Females had a 1.31 (95% CI, 1.27-1.36) increased odds of disease compared to males. Investigating racial and ethnic breakdown, the highest prevalence was found in the Black population (57.8/100,000) (OR 1.06 (1.01-1.10)), followed by the White (54.7/100,000) (REF) and then Hispanic or Latino populations (45.8/100,000) (OR 0.84 (0.79-0.89)) in 2023. Stratified by age, those ages 45-54 had the highest prevalence (71.3/100,000). The prevalence of ON increased 1.08 (1.05-1.10) times from 2016-2023, with the greatest increase seen in the Hispanic population. Significant increases in prevalence were also seen in the 0-14, 15-24, and 25-34 age groups.</p><p><strong>Discussion: </strong>Racial, ethnic and sex disparities are apparent in the distribution of ON, with Black individuals and females affected most often, and an increasing prevalence seen in the Hispanic population. Younger subpopulations also demonstrated significant increases, warranting additional investigation.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1608-1614"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The future of cataract surgery.","authors":"David O'Brart","doi":"10.1038/s41433-025-03745-x","DOIUrl":"10.1038/s41433-025-03745-x","url":null,"abstract":"<p><p>The topic of the 2024 Cambridge Ophthalmology Symposium was \"Evolution and the Eye\". The topic of this paper is to discuss various \"evolutionary\" pressures that may shape the future of cataract surgery (CS) over the next decades. These pressures include: The need to improve CS access; The need to improve sustainability; The development and introduction of new technologies, and the incorporation of artificial intelligence.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1451-1456"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pupil Wizard: an app to enhance knowledge of pupillary abnormalities.","authors":"Øystein Kalsnes Jørstad, Andrew G Lee","doi":"10.1038/s41433-025-03763-9","DOIUrl":"10.1038/s41433-025-03763-9","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1646-1647"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing patient satisfaction and outcomes from the newly established virtual oculoplastic photography (VOP) clinic in a secondary care centre.","authors":"Daniel Curry, Scott Cutting, Sarju Athwal, Mona Khandwala","doi":"10.1038/s41433-025-03766-6","DOIUrl":"10.1038/s41433-025-03766-6","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1443-1445"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143742709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long term analysis of microbiological isolates and antibiotic susceptibilities in acute-onset postoperative endophthalmitis: a UK multicentre study.","authors":"Boon Lin Teh, Ariel Yuhan Ong, Ankur Mehta, Vy Hoang, Chris Settle, Andrew J Lotery, Peter Charbel Issa, Jonathan Smith, David H Steel","doi":"10.1038/s41433-025-03673-w","DOIUrl":"10.1038/s41433-025-03673-w","url":null,"abstract":"<p><strong>Objectives: </strong>To review the trend of microbial isolates for postoperative endophthalmitis (POE) in the United Kingdom (UK) and determine the sensitivity to current empirical intravitreal antibiotic treatment.</p><p><strong>Methods: </strong>We conducted a long term multicentre consecutive case review of POE across 3 geographically distant tertiary eye centres in the UK: Sunderland Eye Infirmary (2000-2022), Oxford Eye Hospital (2016-2022), and Southampton General Hospital (2016-2022). Data on the microbial samples taken and results including sensitivities to antibiotics agents given were collected. Poisson regression was used to analyse microbial trends and outcomes were considered statistically significant at a level of p < 0.05.</p><p><strong>Results: </strong>179 consecutive eyes of 177 patients with POE met our inclusion criteria. The most common primary procedure was phacoemulsification and IOL insertion followed by intravitreal injections. 104 (58.1%) were culture positive and most were Gram-positive bacteria (85, 81.7%). The microbial trend consistently showed Staphylococcus epidermidis and unspecified coagulase-negative Staphylococci to be the most prevalent pathogens. Poisson regression showed no statistically significant change in any of the bacterial isolates over our study period. Antibiotic sensitivity data was available for 74% of the culture positive samples (77/104). All Gram-positive bacteria (68/68, 100%) and most (8/9, 88.9%) Gram-negative bacteria were sensitive to the empirical antibiotics (Vancomycin and Ceftazidime/Amikacin) given at presentation.</p><p><strong>Conclusions: </strong>Most of the bacterial isolates causing POE in the UK are Gram-positive bacteria, and the trend has remained stable over more than two decades. Current empirical treatment with intravitreal Vancomycin and Ceftazidime/Amikacin provides effective broad coverage for the vast majority of cases.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1470-1475"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089534/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographical differences in ophthalmic trauma outcomes and risk factors: the International Globe and Adnexal Trauma Epidemiological Eye Study (IGATES).","authors":"Annette K Hoskin, Sean Ng Ming Sheng, Richard J Blanch, Anantharaman Giridhar, Marian Pauly, Mehul Shah, Alok Sen, Yunia Irawati, Eli Pradhan, Jose Romero, Manisha Agarwal, Mohammad Soleimani, Ashok Kumar Grover, Chitaranjan Mishra, Hugo H Ocampo, Anadi Khatri, Sushank Ashok Bhalerao, Purendra Bhasin, Apoorva Ayachit, Prem S Subramanian, Rekha Khandelwal, Sundaram Natarajan, Manavi D Sindal, Shakeen Singh, Nirmal Fredrick T, Jasmin Zvornicanin, Gangadhara Sundar, José Dalma-Weiszhausz, Amer Awan, Dhanashree Ratra, Kasturi Bhatacharjee, Janejit Choovuthayakorn, Samata Sharma, Yogesh Tawdekar, Chaitra Jayadev, Shanti F Boesoirie, Andres M Rousselot, William Rojas-Carabali, Stephanie L Watson, Bernett Lee, Rupesh Agrawal","doi":"10.1038/s41433-024-03581-5","DOIUrl":"10.1038/s41433-024-03581-5","url":null,"abstract":"<p><strong>Objectives: </strong>Characterise the international variation in ophthalmic trauma and determine risk factors associated with visual and anatomical outcomes for low-, middle- and high-income countries.</p><p><strong>Subjects/methods: </strong>Observational multi-centre cohort study using data from the International Globe and Adnexal Trauma Epidemiological Eye Study (IGATES) from April 2014 to August 2023. Data on acute presentations of ophthalmic injury including open/closed globe injury, and/or Adnexal/orbital involvement, and/or intraocular/ intraorbital foreign body were collected and Ocular Trauma Score (OTS) was calculated. A total of 5350 patients (5557 eyes) from 31 centres in 12 countries were included. The main outcome measures included demographics, mechanism and setting of injury, and presenting and final visual outcomes. Descriptive statistics, Kruskal-Wallis tests and multinomial logistic regression (MLR) analysis are presented, with correction performed using the Hochberg method. P values less than 0.005 were significant.</p><p><strong>Results: </strong>Age, gender, presenting and final best-corrected visual acuity were all strongly associated with country (p < 0.005). Poor final visual outcomes were strongly associated with OTS predictions, type of injury (p < 0.005) and delayed presentation as well as firework injuries. High-income countries (HIC) showing reduced duration to presentation (HIC 5 h) and increased improvement in visual acuity (HIC -0.40) compared to low to middle-income countries (LMICs) (28 h) (-0.19). MLR analysis identified a significant association between countries' income classification and BCVA worse than 6/60, presence of scleral, iris, limbus injury and surgery being undertaken (p < 0.005).</p><p><strong>Conclusion: </strong>Data from 31 centres internationally identified differences in demographic trends for each country. Age was identified as a risk factor for eye injuries. Low- and middle-income countries were associated with longer delays to presentation, smaller gains in BCVA and poorer visual outcomes. IGATES provides an opportunity to collect global data on ophthalmic trauma to facilitate improved management and prevention strategies.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1532-1539"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atopic disease and astigmatism: a population-based study.","authors":"Margarita Safir, Itay Nitzan, Yair Hanina, Ari Safir, Eliya Levinger, Dan Heller, Nir Sorkin","doi":"10.1038/s41433-025-03712-6","DOIUrl":"10.1038/s41433-025-03712-6","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the relationship between atopic disease and astigmatism in adolescence and young adulthood.</p><p><strong>Methods: </strong>In this population-based cross-sectional study 897,811 medical records of Israeli adolescents and young adults without keratoconus were reviewed. The prevalence of low-to-moderate (3.00 > D ≥ 0.75) and high ( ≥ 3.00 D) astigmatism were calculated in cases with and without atopic disease, including ocular atopic disease (OAD), asthma, allergic rhinitis, atopic dermatitis, angioedema/urticaria, and history of anaphylaxis. Relationships were analysed using multinominal logistic regression, with adjustments for relevant sociodemographic factors.</p><p><strong>Results: </strong>A total of 897,811 adolescents were included in the analysis (mean age 17.2 ± 0.8 years, 57.8% men). OAD was found in 4702 individuals, with a prevalence of 0.5%. Adolescents with OAD demonstrated a gradual increase in odds ratio (OR) for low-to-moderate and for high astigmatism (OR 1.16, 95% CI 1.07-1.27 and OR 2.10, 95% CI 1.63-2.70, respectively). This group also showed increased OR for with-the-rule astigmatism (OR 1.34, 95% CI 1.21-1.48). Other atopic diseases were associated with more modest ORs for low-to-moderate (OR 1.09, 95% CI 1.07-1.11) and for high astigmatism (OR 1.10, 95% CI 1.02-1.19), persisting across all axis orientations. Sensitivity analysis revealed a dose-response relationship between OAD severity and astigmatism, and consistent point estimates in a group of 1331 adolescents diagnosed with OAD during military service.</p><p><strong>Conclusions: </strong>This study establishes an association between OAD and astigmatism, highlighting the importance of effective OAD management. Further research into tailored therapeutic interventions that address both conditions concurrently is needed.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1694-1699"},"PeriodicalIF":2.8,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}