Eye最新文献

{"title":"Status of papillomacular bundle in optic disc pit associated with maculopathy.","authors":"Dmitrii S Maltsev, Alexei N Kulikov, Yana A Kalinicheva, Daniela Bacherini, Jay Chhablani","doi":"10.1038/s41433-025-03761-x","DOIUrl":"https://doi.org/10.1038/s41433-025-03761-x","url":null,"abstract":"<p><strong>Purpose: </strong>To study the status of papillomacular bundle (PMB) in eyes with optic disc pit.</p><p><strong>Methods: </strong>Electronical medical records and optical coherence tomography (OCT) data of patients with optic disc pit were retrospectively reviewed. The PMB defect was measured on structural en face OCT projections. Length of ellipsoid zone defect (EZD) in the centre of the macula was measured on a horizontal cross-sectional scan passing through the centre of the fovea. Correlation between parameters under study, central retinal thickness (CRT), and visual acuity was calculated.</p><p><strong>Results: </strong>Thirteen eyes of thirteen patients (seven males and six females, mean age 31.3 ± 11.6 years) with optic disc pit and maculopathy and two eyes of two patients without maculopathy (2 females, 21 and 23 years) were included. The defect of PMB was found in 12 out 13 eyes (92.3%) with maculopathy. In those eyes EZD was found in 11 out of 13 eyes (84.6%). Among 12 eyes with PMB defect, 11 eyes had EZD (92.6%), one eye had PMB defect without EZD, while no eyes had EZD without PMB defect (p = 0.01). Mean PMB defect width was 0.86 ± 0.64 mm. Mean length of EZD was 425 ± 423 µm. The length of EZD and PMB width were highly correlated (r = 0.71, p < 0.001). Two eyes without maculopathy demonstrated no papillomacular bundle defect.</p><p><strong>Conclusion: </strong>Papillomacular bundle defect may be one of the essential characteristics in the optic disc pit with maculopathy and can be associated with the alteration of the central retina in these eyes.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SIRE: Short interval in real life Does intensive anti-VEGF treatment in the first year predict subsequent treatment burden in exudative age-related macular degeneration?","authors":"B Matagrin, I Fenniri, N Chirpaz, J Billant, E Agard, R Chudzinski, C Burillon, C Dot","doi":"10.1038/s41433-025-03734-0","DOIUrl":"10.1038/s41433-025-03734-0","url":null,"abstract":"<p><strong>Background: </strong>Anti-VEGF's have changed the prognosis of exudative age-related macular degeneration (AMD). Ranibizumab and aflibercept have proven their functional efficacy, but their use has revealed in real life a wide variety of patient profiles with varied responses to treatment. This work focused on patients receiving \"intensive\" IVT treatment with a sustained injection rhythm, also referred to as having a high treatment burden.</p><p><strong>Objective: </strong>The main objective of this work was to determine, in real-life conditions, the proportion of patients receiving \"intensive\" treatment among those being followed for exudative AMD. Secondary objectives were to analyse the long-term functional outcomes of these patients, their anatomical characteristics, and the evolution of their treatment regimen.</p><p><strong>Method: </strong>A retrospective descriptive single-centre real-life study was conducted on patients treated for exudative AMD with intensive treatment (intervals of less than 8 weeks during the first year of treatment). A subgroup analysis compared patients who exceeded Q8 during follow-up (Group 1) versus patients remaining in intensive treatment (Group 2).</p><p><strong>Results: </strong>A total of 301 records were analysed, with 24.9% of the eyes (n = 75) considered under intensive treatment. The mean age was 84 years ( ± 7.5), and 61% were men. Type 1 choroidal neovascularization (CNV) accounted for 64% of our cohort, type 2 CNV represented 29.3%, and type 3 was involved in 6.7%. The mean follow-up was 5.6 years ( ± 3.6), with an average number of 41 IVT ( ± 26.7). Visual acuity was maintained at 0.53 ( ± 0.2) baseline vs. 0.61 ( ± 0.2) after 5 years of follow-up (p = 0.02). Central retinal thickness (CRT) and subretinal fluid (SRF) were significantly reduced during our follow-up, and PED height remained stable. Almost half of the eyes (44%) had an extension of their interval ( > Q8) beyond the first year; however, this objective was achieved on average after 4.5 years of treatment. The visual acuity of Group 2 ( < Q8), despite receiving more injections, was superior to that of Group 1 ( > Q8) with baseline values of 0.57 ( ± 0.2) and 0.48 ( ± 0.2) (p = 0.161) respectively, and at 5 years 0.79 ( ± 0.2) and 0.54 ( ± 0.2) (p = 0.026). Similarly, CRT, PED height, and SRF were higher in Group 2. The distribution of neovascular types showed more type 2 in Group 1 (45.5% vs. 16.7%).</p><p><strong>Conclusion: </strong>Patients requiring intensive treatment represent about ¼ of our AMD patient population. Despite the high treatment burden, these patients maintain their visual acuity at 5 years. An extension of intervals is observed in nearly half of the patients, occurring late. Intensive treatment during the first year appears to be predictive of a future hight treatment burden.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The UK paediatric ophthalmology workforce crisis - a national perspective.","authors":"Neil Clough, Tejal Magan, Saurabh Jain","doi":"10.1038/s41433-025-03755-9","DOIUrl":"https://doi.org/10.1038/s41433-025-03755-9","url":null,"abstract":"<p><strong>Introduction: </strong>The significant and pressing workforce issues facing paediatric ophthalmology were highlighted by the 2022 RCOphth census. Here we present a national UK survey with the aim of deepening the understanding of the size and contributing factors, and inform future strategies.</p><p><strong>Methods: </strong>In September 2023 an online questionnaire survey link was sent to U.K. based ophthalmologists. Questions were tailored to separate groups; ophthalmologists in training (OST registrars), ophthalmologists in training (fellows), paediatric ophthalmology consultants, or SAS (specialist, associate specialist and specialty doctors). OST registrars were questioned on quality of teaching, experience, dissuading factors from pursuing paediatric ophthalmology and career plans. Fellows were questioned on career plans. Paediatric ophthalmology consultants and SAS doctors were questioned workforce issues and solutions to recruitment.</p><p><strong>Results: </strong>145 responses: 53.8% (78/145) OST registrars, 7.6% (11/145) fellows, 37.9% (55/145) consultants and 0.7% (1/145) SAS doctors. 87% (67/77) of OST registrars did not want a career in paediatric ophthalmology, citing complexity of strabismus and discomfort with examining children as dissuading factors. 59.6% of consultants reported one or more departmental paediatric ophthalmology vacancies, and identified early sub-specialty exposure and increased emphasis on teaching as solutions to recruitment. SAS doctors reported a desire for career development support.</p><p><strong>Conclusion: </strong>We present a national survey exploring the workforce issues facing paediatric ophthalmology in the UK. Our results suggest the situation is set to worsen in the short term. Potential solutions are early sub-specialty exposure and increased emphasis on paediatric ophthalmology teaching during training.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New frontiers in generative artificial intelligence - enhancing custom GPTs with ophthalmology guidelines.","authors":"Andrea Taloni, Giuseppe Alessio, Giulia Coco, Vincenzo Scorcia, Angeli Christy Yu, Luigi De Rosa, Niccolò Salgari, Massimo Busin, Giuseppe Giannaccare","doi":"10.1038/s41433-025-03746-w","DOIUrl":"https://doi.org/10.1038/s41433-025-03746-w","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diameter of cystoid spaces and choroidal hypertransmission as novel prognostic biomarkers in myopic foveoschisis.","authors":"Emanuele Crincoli, Alfonso Savastano, Maria Cristina Savastano, Clara Rizzo, Raphael Kilian, Umberto De Vico, Ilaria Biagini, Matteo Maria Carlà, Federico Giannuzzi, Stanislao Rizzo","doi":"10.1038/s41433-025-03738-w","DOIUrl":"https://doi.org/10.1038/s41433-025-03738-w","url":null,"abstract":"<p><strong>Purpose: </strong>To analyse optical coherence tomography (OCT) biomarkers of anatomical and functional success in myopic foveoschisis (MF) (stage I and II of ATN classification) undergoing pars plana vitrectomy (PPV).</p><p><strong>Materials and methods: </strong>Isolated MF cases who underwent PPV showing preoperative optical coherence tomography (OCT)-documented integrity of the foveal ellipsoid zone (EZ) and retinal pigmented epithelium (RPE) were included. Availability of good quality preoperative and 1-year-postoperative OCT acquisitions was also mandatory for inclusion. Anatomical success was defined as persistence of <20% of preoperative cystoid spaces within the parafoveal region and preservation of the foveal EZ and RPE. Functional success was defined as postoperative improvement of at least 10 ETDRS letters.</p><p><strong>Results: </strong>Anatomical success was obtained in 86.1% cases (31/36). A significantly higher prevalence of preoperative choroidal hypertransmission (CH) with preserved EZ and RPE was detected in the anatomical failure group. Functional success was reported in 72.2% of cases. A larger diameter of preoperative foveal cysts and the presence of a cotton ball sign were associated with a worse functional outcome. Dome shaped macula (DMS) was associated to a good anatomical and functional outcome.</p><p><strong>Conclusions: </strong>Our retrospective analysis highlighted that the preoperative presence of a foveal CH with preserved foveal EZ and RPE might be predictive a postoperative anatomical and functional failure in MF surgery. By contrast, a larger diameter of foveal cysts might be associated to functional failure despite anatomical success, while DMS might be a predictor of good prognosis. Assessment of the described biomarkers on a larger prospective cohort is needed to validate our findings.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of dome-shaped macula in mild myopic or non-myopic eyes.","authors":"Mengyang Li, Zhi Li, Fei Xiang, Caixia Li, Ye Zhang, Shuning Li","doi":"10.1038/s41433-025-03756-8","DOIUrl":"https://doi.org/10.1038/s41433-025-03756-8","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate dome-shaped macula (DSM) in mild myopic or non-myopic eyes.</p><p><strong>Methods: </strong>Participants aged 50 years or older were recruited from July 2023 to August 2023. Clinical features including age, sex, visual acuity (VA), spherical equivalent refraction (SER), ocular biometry parameters, SS-OCT parameters and macular complications were compared between eyes with and without DSM. Logistic analysis was performed to explore risk factors for DSM.</p><p><strong>Results: </strong>923 eyes were enrolled in the final analysis. The overall prevalence of DSM was 3.03% (28/923). Among eyes with DSM, 13 eyes (46.4%) were emmetropia, 9 eyes (32.1%) were hypermetropia, and 6 eyes (21.4%) were myopia, with 4 eyes (14.3%) were mild myopia and one eye (3.6%) was moderate myopia. The mean subfoveal choroidal thickness (SFCT) in eyes with DSM was 168.00 ± 77.79μm, which was significantly thinner than their counterparts absent of DSM (289.11 ± 95.58μm, p < 0.001). Logistic regression revealed that longer AL (odds ratio (OR) = 1.716, 95%CI: 1.205-2.442, p = 0.003) and female sex (OR = 3.330, 95% CI: 1.109-10.005, p = 0.032) were associated with DSM. No vitreomacular complication including epiretinal membrane (ERM), vitreomacular traction (VMT), lamellar macular hole (LMH) and full-thickness macular hole (FTMH) was found in eyes with DSM, while the overall prevalence of those macular complications in eye without DSM was 8.8% (79/895).</p><p><strong>Conclusions: </strong>The study offered a detailed profile of DSM in mild myopic or non-myopic eyes and found a diffuse thinning of choroid in both foveal and parafoveal area in eyes with DSM. No case with vitreomacular complications was identified in DSM eyes in our study population.</p><p><strong>Trail registration: </strong>The registration number of the present trial in the Chinese Clinical Trial Registry is ChiCTR2000037944.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of uveitis manifestations in patients with active systemic tuberculosis and those with positive interferon-gamma release assay without active disease.","authors":"Ikhwanuliman Putera, Aniki Rothova, Rina La Distia Nora","doi":"10.1038/s41433-025-03751-z","DOIUrl":"https://doi.org/10.1038/s41433-025-03751-z","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical manifestations of uveitis in patients with active systemic tuberculosis (TB) and compare them to those with uveitis of undetermined cause who were positive for the interferon-gamma release assay (IGRA) but did not have active systemic TB.</p><p><strong>Methods: </strong>This retrospective study included 118 patients: 51 with uveitis and active systemic TB, 52 with undetermined cause of uveitis and positive IGRA but no active systemic TB, and 15 with positive Mycobacterium tuberculosis (Mtb) polymerase chain reaction (PCR) results from ocular fluids but no active systemic TB. Demographic data, ocular findings, and systemic TB investigations were analysed and compared.</p><p><strong>Results: </strong>Patients with evidence of active TB were predominantly younger. Typical manifestations of ocular TB (OTB) were more frequently observed in patients with active systemic TB (p < 0.001) and were significantly associated with younger age (p = 0.002). In patients without active systemic TB but positive Mtb PCR from ocular fluid, ocular manifestations closely resembled those of patients with active systemic TB, particularly with respect to the presence of choroidal granulomas. In contrast, patients with an undetermined cause of uveitis who tested positive for IGRA were older, and their clinical features were more often atypical.</p><p><strong>Conclusions: </strong>Uveitis associated with active systemic TB was characterised by typical OTB manifestations and occurred more frequently in younger patients. These findings highlight the importance of considering TB in the differential diagnosis of uveitis, especially in younger individuals, and suggest that atypical manifestations may be more common in older patients and in patients without active TB.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients' perspective on the environmental impact of the severe dry eye disease healthcare pathway.","authors":"Samuel Latham, Laura Boddy, Tara McClay, Matteo Airaldi, Alfredo Borgia, Alina Cordos, Andrea Madden, Alexander Undan, Jeremy Hoffman, Daniel Sibley, Sajjad Ahmad, Stephen Kaye, David Lockington, Saaeha Rauz","doi":"10.1038/s41433-025-03747-9","DOIUrl":"https://doi.org/10.1038/s41433-025-03747-9","url":null,"abstract":"<p><strong>Background: </strong>The NHS has committed to achieving net-zero carbon emissions by 2045. Dry eye disease, a chronic condition affecting approximately 29.5% of the global population, poses a significant challenge due to its environmentally harmful care pathway, which also exacerbates the condition. This research article presents a multi-centre cross-sectional survey of patients with severe dry eye disease to examine the pollution and emissions associated with the NHS dry eye disease care pathway. The aim is to identify target areas where innovation can aid the NHS in reaching its net-zero goal.</p><p><strong>Methods: </strong>Ninety-two patients participated in semi-structured interviews at four tertiary care centres in the United Kingdom.</p><p><strong>Results: </strong>Medication packaging disposal was reported as follows: 36% of patients disposed of everything in household waste, 13% recycled everything, and 51% used a mixture of both. Only 7% of patients reported that medication packaging had clear recycling instructions, 23% reported no instructions, and 71% had not noticed. Patients attended a median of 3 (range; 1, 15) hospital appointments per year, with 62% traveling by car and a median return journey time of 100 (8, 300) minutes. When asked if having dry eye disease significantly increased their carbon footprint, 32% agreed, 32% were unsure, and 37% disagreed. The predominant suggestion for reducing environmental harm was \"environmentally friendly packaging.\"</p><p><strong>Conclusion: </strong>This research highlights the need for more sustainable packaging solutions, including clearer recycling instructions, and explores issues related to avoidable travel and insufficient education. By addressing these areas, the NHS can make significant progress towards achieving its net-zero emissions goal.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral peripheral retinoschisis with vitreous retinal traction.","authors":"Jinyuan Wang, Haihan Zhang, Wenbin Wei","doi":"10.1038/s41433-025-03703-7","DOIUrl":"https://doi.org/10.1038/s41433-025-03703-7","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between complete polypoidal regression and visual outcomes in polypoidal choroidal vasculopathy eyes receiving intravitreal aflibercept.","authors":"Voraporn Chaikitmongkol, Patcharawan Chatromyen, Janejit Choovuthayakorn, Direk Patikulsila, Paisan Ruamviboonsuk, Pichai Jirarattanasopa, Nawat Watanachai, Paradee Kunavisarut, Mansing Ratanasukon, Patama Bhurayanontachai, Neil M Bressler","doi":"10.1038/s41433-025-03750-0","DOIUrl":"https://doi.org/10.1038/s41433-025-03750-0","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}