Eye最新文献

{"title":"Should poor sleep be added to the list of risk factors for normal-tension glaucoma in the future?","authors":"Peter Wostyn, Maiken Nedergaard","doi":"10.1038/s41433-025-03748-8","DOIUrl":"10.1038/s41433-025-03748-8","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1233-1234"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of corneal vessels activity through the 'Barcode sign' of corneal OCT.","authors":"Farida Omar Elzawahry, Prity Sahay, Dalia Said, Harminder Singh Dua","doi":"10.1038/s41433-024-03558-4","DOIUrl":"10.1038/s41433-024-03558-4","url":null,"abstract":"<p><strong>Background/objectives: </strong>Anterior segment optical Coherence Tomography (AS-OCT) is used extensively in imaging the cornea in health and disease. Our objective was to analyse and monitor corneal vascularisation (CVas) through the corresponding back-shadows visible on AS-OCT.</p><p><strong>Subjects/methods: </strong>AS-OCT scans were obtained from 26 consecutive patients (eyes) with CVas of different aetiologies. AS-OCT horizontal line scans showing the back shadows cast by the vessels were analysed and correlated with findings seen on slit lamp examination. Vessels were graded clinically as active, partially regressed, and regressed. The density of back shadow in the patient samples before and after treatment was analysed using Image-J software.</p><p><strong>Results: </strong>AS-OCT demonstrated a dense back shadow in all the 26 active vessels studied. When multiple vessels were present, the barcode sign was apparent. The back shadows absent in 22 (84.62%) at the regressed (healed) stage. The intensity of the backshadow had reduced in regressing vessels 4 (15.38%). The integrated density of the backshadow on AS-OCT in the active stage (pre-treatment) and corresponding healed (post-treatment, partially regressed or ghost vessels) scans was statistically significantly different (P < 0.0001).</p><p><strong>Conclusion: </strong>This study demonstrates that AS-OCT provides additional important information in patients with CVas enabling distinction between active and regressing/regressed vessels. Semiquantitative assessment can be made by measuring the integrated density of the back shadows produced by the vessels.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1332-1336"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of quantitative OCT and SS-OCTA metrics three months after initiation of intravitreal faricimab for treatment-recalcitrant neovascular AMD.","authors":"Arnold Nadel, Michael Drakopoulos, Harnaina K Bains, Avram Bar-Meir, Alessandro Marchese, Alice T Lyon, Rukhsana G Mirza","doi":"10.1038/s41433-024-03583-3","DOIUrl":"10.1038/s41433-024-03583-3","url":null,"abstract":"<p><strong>Purpose: </strong>To utilize optical coherence tomography (OCT) and SS-OCT angiography (SS-OCTA) for quantifying morphological changes seen in eyes with recalcitrant neovascular age-related macular degeneration (nAMD) transitioned to intravitreal faricimab injections during the manufacturer's recommended induction phase of treatment.</p><p><strong>Methods: </strong>Fifty-four treatment-recalcitrant patients (60 eyes) were recruited. OCT and SS-OCTA images were obtained at 0 and 3 months. Best-corrected visual acuity (BCVA), OCT, pigment epithelial detachment (PED), and macular neovascularization (MNV) parameters were analyzed at baseline and 3 months.</p><p><strong>Results: </strong>Thirty-two patients (38 eyes) were included in the baseline OCT characteristic analysis, 29 patients (35 eyes) in the MNV analysis, and 18 patients (21 eyes) in the PED analysis. Significant decreases in PED parameters were observed, including PED volume (mean decrease of 0.0592 mm³ (-19.66%; p = 0.0164), sample standard deviation (ssd) = 0.114 mm³), mean height (mean decrease of 0.00871 mm (-19.16%; p = 0.0003), ssd = 0.0143 mm), and maximum height (mean decrease of 0.0242 mm (-15.28%; p = 0.002), ssd = 0.0359). Significant decreases in MNV metrics were also observed, including area (mean decrease of 0.252 mm² (-9.06%; p = 0.0054), ssd = 0.519 mm²), and vessel area density (mean decrease of 6.51% absolute (-8.23%; p = 0.0004), ssd = 0.0943% absolute). BCVA (logMAR) remained stable between baseline and 3 months (0.25-0.23; p = 0.34). Notably, there were no statistically significant changes in the percentage of eyes with intraretinal fluid (IRF) or subretinal fluid (SRF) between baseline and 3 months (all p > 0.05).</p><p><strong>Conclusions: </strong>In recalcitrant nAMD patients who were transitioned to faricimab, patients maintained their vision while significant improvements in OCT PED and SS-OCTA MNV parameters were seen during the induction phase.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1337-1343"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043917/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143036942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world outcomes of Voretigene Neparvovec: a single-centre consecutive case series.","authors":"Assad Jalil, Mariantonia Ferrara, Myrta Lippera, Neil Parry, Graeme C Black, Sandra Banderas, Jane Ashworth, Sus Biswas, Georgina Hall, Jane Gray, William Newman, Tsveta Ivanova","doi":"10.1038/s41433-025-03637-0","DOIUrl":"10.1038/s41433-025-03637-0","url":null,"abstract":"<p><strong>Purpose: </strong>To present functional and anatomical outcomes of subretinal therapy with Voretigene Neparvovec (VN) in patients treated in one of the four specialist UK gene therapy centres.</p><p><strong>Methods: </strong>Single-centre, retrospective case series of patients affected by an inherited retinal dystrophy (IRD) caused by a pathogenic biallelic RPE65 mutation and treated with VN. Complete ophthalmic examination was planned preoperatively and 2, 4 and 8 weeks and 3, 6, 12, 18 and 24 months after surgery, and included visual acuity (VA) assessment (normal and low luminance), colour vision, contrast sensitivity, dark-adapted full-field stimulus threshold, macular optical coherence tomography (OCT) and fundus autofluorescence.</p><p><strong>Results: </strong>Fourteen eyes of 8 patients were included with a mean follow-up of 26 months. Mean final VA improved by 2 lines, and improvements were noted in most other functional tests. Central retina thickness (CRT) remained fairly stable in the majority of patients, whereas 2 eyes experienced a reduction >30 μm. The status of ellipsoid band and external limiting membrane remained stable in all patients, except one. Peripapillary atrophy (PPA) was present in 5 eyes of 3 patients at the baseline; postoperative progression was noted in both eyes of one patient. No patient developed new PPA or chorioretinal atrophy (CRA) involving the macular area after treatment. Five eyes of 3 patients developed CRA at the retinotomy site, that progressed in 3 of them.</p><p><strong>Conclusions: </strong>Our study confirmed the effectiveness of subretinal VN therapy in terms of improvement of visual function. CRA was confirmed as a common postoperative complication, with limited functional impact.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1356-1363"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of cataract surgery with stroke among older adults in the United States.","authors":"Tsung-Hsien Tsai, Yuan-Ting Chang, Yu-Chen Cheng","doi":"10.1038/s41433-025-03662-z","DOIUrl":"10.1038/s41433-025-03662-z","url":null,"abstract":"<p><strong>Background/objectives: </strong>Cataract surgery, one of the most frequent conducted surgeries around the world, is associated with cardiovascular diseases. We aim to determine the association of cataract surgery and the risk of stroke.</p><p><strong>Methods: </strong>Adults aged over 65 years old in the National Health and Aging Trends Study were followed 7 years annually. There were 6700 stroke-free participants included at baseline survey. These participants were divided into two groups based on past history of cataract surgery. Demographics and multiple comorbidities were compared between the two groups. We identified newly developed cases of stroke over a 7-year period and performed survival analysis. Cox regression was further performed to yield adjusted hazard ratios.</p><p><strong>Results: </strong>Among 6700 elderly participants, 2803 of them had a history of cataract surgery while 3897 of them had not. Over the 7-year follow-up period, the cumulative stroke-free survival rate among the cataract surgery group and the control group were 84.4% versus 88.6% (p < 0.0001, log-rank test). Compared with the control group, elderly with a history of cataract surgery had a higher risk of developing stroke (adjusted HR 1.36, 95% CI 1.03 to 1.79, p = 0.026) after adjusting for multiple covariates. Other significant predictors included age ≥80 years old, having comorbidities with heart disease, lung disease, and dementia. Contrarily, protective factors for further stroke development included higher education and more frequent outdoor activities.</p><p><strong>Conclusions: </strong>Our findings suggest that patients with a history of cataract surgery had a 1.36-fold increased risk of future stroke development.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1400-1405"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Comparative analysis of large language models against the NHS 111 online triaging for emergency ophthalmology\".","authors":"Shaheryar Ahmed Khan, Chrishan Gunasekera","doi":"10.1038/s41433-025-03605-8","DOIUrl":"10.1038/s41433-025-03605-8","url":null,"abstract":"<p><strong>Background: </strong>This study presents a comprehensive evaluation of the performance of various large language models in generating responses for ophthalmology emergencies and compares their accuracy with the established United Kingdom's National Health Service 111 online system.</p><p><strong>Methods: </strong>We included 21 ophthalmology-related emergency scenario questions from the NHS 111 triaging algorithm. These questions were based on four different ophthalmology emergency themes as laid out in the NHS 111 algorithm. Responses generated from NHS 111 online, were compared to different LLM-chatbots responses to determine the accuracy of LLM responses. We included a range of models including ChatGPT-3.5, Google Bard, Bing Chat, and ChatGPT-4.0. The accuracy of each LLM-chatbot response was compared against the NHS 111 Triage using a two-prompt strategy. Answers were graded as following: -2 graded as \"Very poor\", -1 as \"Poor\", O as \"No response\", 1 as \"Good\", 2 as \"Very good\" and 3 graded as \"Excellent\".</p><p><strong>Results: </strong>Overall LLMs' attained a good accuracy in this study compared against the NHS 111 responses. The score of ≥1 graded as \"Good\" was achieved by 93% responses of all LLMs. This refers to at least part of this answer having correct information as well as absence of any wrong information. There was no marked difference and very similar results seen overall on both prompts.</p><p><strong>Conclusions: </strong>The high accuracy and safety observed in LLM responses support their potential as effective tools for providing timely information and guidance to patients. LLMs hold promise in enhancing patient care and healthcare accessibility in digital age.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1301-1308"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomy of the infraorbital artery and its orbital branch.","authors":"Jessica Y Tong, Jeffrey Sung, WengOnn Chan, Alkis J Psaltis, Dinesh Selva","doi":"10.1038/s41433-025-03671-y","DOIUrl":"10.1038/s41433-025-03671-y","url":null,"abstract":"<p><strong>Background/objectives: </strong>To characterise the infraorbital artery (IOA) and its orbital branch, which are key structures encountered during inferior orbital explorations, with potential for orbital haemorrhage and vision loss if inappropriately handled.</p><p><strong>Methods: </strong>Thirteen embalmed heads (26 orbits) were dissected. The following parameters were measured: orientation of the IOA in relation to the infraorbital nerve (ION); presence or absence of the orbital branch of the IOA; and the distance between the orbital branch of the IOA to the inferior orbital rim.</p><p><strong>Results: </strong>In the pterygopalatine fossa, the orientation of the IOA relative to V2 was medial (n = 9, 34.6%), inferior (n = 4, 15.4%), lateral (n = 4, 15.4%), inferolateral (n = 3, 11.5%), superolateral (n = 3, 11.5%), inferomedial (n = 2, 7.7%) and superior (n = 1, 3.8%). In the infraorbital canal, the IOA in relation to the ION was as follows: superomedial (n = 12, 46.2%), medial (n = 9, 34.6%), superior (n = 2, 7.7%), inferomedial (n = 2, 7.7%) and superolateral (n = 1, 3.8%). An orbital branch of the IOA was identified in 21/26 orbits (80.8%). The mean distance of the orbital branch to the inferior orbital rim was 13.0 ± 4.8 mm (range 2.0-23.0 mm).</p><p><strong>Conclusions: </strong>The IOA is an important vascular structure to recognise during inferior orbitotomies. The most common configuration is an IOA that runs medially to V2 in the pterygopalatine fossa, then superomedially to the ION within the infraorbital canal. The orbital branch of the IOA emerges 13 mm posterior to the inferior orbital rim. Recognition of these arterial branches and appropriate cauterization are paramount for avoiding significant operative complications.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1380-1383"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-human primates as preclinical models for optic nerve research: advancing insights into their application and potential.","authors":"Lijie Pan, Ningli Wang, Jian Wu","doi":"10.1038/s41433-025-03665-w","DOIUrl":"10.1038/s41433-025-03665-w","url":null,"abstract":"<p><p>Optic neuropathies are a group of disorders characterized by damage or dysfunction of the optic nerve, which transmits visual information from the retina to the brain. Common causes include glaucoma, ischemic optic neuropathy, optic neuritis, hereditary optic neuropathies and traumatic or compressive optic neuropathies. These conditions can result in vision loss, decreased visual acuity, color vision defects, and visual field abnormalities. The effective treatment strategies have been urgently addressed for long. Consequently, development of both spontaneous and experimental disease models is crucial to thoroughly illustrate disease property and biological mechanisms. As the largest ocular study conducted in non-human primates (NHPs), NHP eye study (NHPES) provided a comprehensive insight into optic nerve survey by launching normal range of relevant parameters and some spontaneous optic nerve disorders, laying the foundation for translation from monkey models to human clinical applications. NHPs are the most ideal animal models because of the marked species proximity through evolution between them and human, so substantial efforts have been attempted toward establishing NHP models for optic nerve research. These animals are of great importance for accelerating the exploitation of novel treatment targets, promoting advantageous drug delivery methods and enhancing patients' outcomes. Furthermore, the sophisticated structure and physiological function of monkeys faithfully replicate the typical pathology and progression of specific diseases. In the current narrative review, we provide an overview of why NHPs could be used to study the optic nerve and the significance of NHPES compared with other eye studies of monkeys.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1254-1263"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043956/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality and ocular parameters and diseases.","authors":"Mukharram M Bikbov, Gyulli M Kazakbaeva, Ellina M Rakhimova, Songhomitra Panda-Jonas, Azaliia M Tuliakova, Albina A Fakhretdinova, Jost B Jonas","doi":"10.1038/s41433-025-03615-6","DOIUrl":"10.1038/s41433-025-03615-6","url":null,"abstract":"<p><strong>Background: </strong>To assess associations between mortality and major ocular parameters and diseases.</p><p><strong>Methods: </strong>The population-based Ural Eye and Medical Study (UEMS) and Ural Very Old Study (UVOS) included 5899 individuals (age: 40+ years) and 1526 individuals (age: 85+ years), respectively. Cause-specific mortality was determined using the government regional information and analytical system.</p><p><strong>Results: </strong>In the UEMS, 689 (11.7%) participants had died during the follow-up of 7.0 ± 0.4 years (median: 6.9 years). Higher death occurrence was associated (multivariable analysis) with lower best corrected visual acuity (OR: 1.86; 95%CI:1.10, 2.68) and higher prevalence of diabetic retinopathy (OR: 2.97; 95%CI: 1.68, 5.26), with adjusting for older age (OR: 1.08), male sex (OR: 4.18), higher waist-hip ratio (OR: 5.53), current smoking (OR: 2.25), history of cancer (OR: 1.93) and dementia (OR: 2.54), higher serum concentration of glucose (OR: 1.13) and lower serum concentration of high-density lipoproteins (OR: 0.89) and haemoglobin (OR: 0.99), higher leucocyte count (OR: 1.07), higher prevalence of chronic obstructive pulmonary disease (OR: 1.67), higher stage of arterial hypertension (OR: 1.15), and higher depression score (OR: 1.04). Death occurrence was not significantly associated with prevalence of age-related macular degeneration (P = 0.90), macular reticular pseudodrusen (P = 0.90), open-angle glaucoma (P = 0.11), angle-closure glaucoma (P = 0.98), nuclear cataract (P = 0.07), cortical cataract (P = 0.46), axial length (P = 0.44) and intraocular pressure (P = 0.87). In the UVOS, 791 (51.9%) participants had died during the follow-up of 4.8 ± 1.0 years (median: 5.2 years). None of the ophthalmological parameters was significantly associated with death occurrence.</p><p><strong>Conclusions: </strong>Diabetic retinopathy was the only major ophthalmic disease or parameter, in addition to vision impairment, which was associated with an increased death risk.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1322-1331"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1-Year real-world outcomes of faricimab in previously treated neovascular age-related macular degeneration.","authors":"Imran Karim Janmohamed, Adeel Mushtaq, Jamil Kabbani, Simeon Harrow, Aaruran Nadarajasundaram, Anibe Ata, Henrietta Monye, Zakariya Jarrar, Shabeeba Hannan, Luke Membrey","doi":"10.1038/s41433-025-03616-5","DOIUrl":"10.1038/s41433-025-03616-5","url":null,"abstract":"<p><strong>Background and objectives: </strong>Faricimab, a bispecific antibody targeting VEGF-A and angiopoietin-2, has shown promise in treating neovascular age-related macular degeneration (nAMD). This study evaluates 1-year outcomes of faricimab in treatment-experienced nAMD patients.</p><p><strong>Methods: </strong>This single-centre retrospective cohort study included patients previously treated for nAMD who switched to faricimab between November 2022 and March 2024. Best-corrected visual acuity (BCVA), central macular thickness (CMT), and treatment intervals were assessed at baseline, 6, and 12 months.</p><p><strong>Results: </strong>One hundred eighty-four patients (215 eyes) were included. Patients had received a median of 18 (interquartile range [IQR] 10-28.5) anti-VEGF injections per eye over an average of 5.02 ± 11.82 years before switch. An average of 8.63 ± 2.2 faricimab injections were administered per eye over an average follow-up of 12.19 ± 2.70 months. Median BCVA decreased from 70 ETDRS letters (IQR 55-76) at baseline to 62 (IQR 47-76) at 12 months (p = 0.0038). Median CMT improved from 259.5 μm (IQR 223-299.75) at baseline to 232 μm (202.0-272.5) at 12 months (p < 0.0001). At the last follow-up, 40.2% of eyes were dry on OCT. The median dosing interval doubled from 4 weeks (IQR 4-4) to 8 weeks (IQR 6-10) with faricimab (p < 0.0001). 47.4% and 16.3% of eyes achieved treatment intervals of ≥8-12 weeks and ≥12 weeks, respectively. Three events of uveitis were noted following the loading phase.</p><p><strong>Conclusions: </strong>This real-world study demonstrates that faricimab maintains vision and achieves significant anatomical improvements in treatment-experienced nAMD patients. The extended treatment intervals could significantly reduce the burden on patients and healthcare resources.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1344-1348"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143036844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}