Eye最新文献

{"title":"Comment on: \"Multimodal deep learning prediction of treatment response to anti-vascular endothelial growth factor in diabetic macular oedema\".","authors":"Ashith Tripathi, Raj Kumar","doi":"10.1038/s41433-026-04852-z","DOIUrl":"https://doi.org/10.1038/s41433-026-04852-z","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive heuristics in the operating room: the role of 'left-digit bias' in ophthalmic surgical selection.","authors":"Kara Sangiuolo, Rachel Zhang, Jainam Shah, Lily Young, Zara Mian, Jee-Young Moon, Jeffrey Schultz, Anurag Shrivastava","doi":"10.1038/s41433-026-04926-y","DOIUrl":"https://doi.org/10.1038/s41433-026-04926-y","url":null,"abstract":"<p><strong>Introduction: </strong>Left-digit bias is a cognitive heuristic in which the leftmost digit of a number disproportionately influences judgment. This study evaluates the impact of perceived patient age on ophthalmic surgical decision-making.</p><p><strong>Methods: </strong>Using a multicentre federated electronic health record network, patients aged 40-85 years with a routine health visit, followed by at least 1 documented ophthalmic examination and a diagnosis code specific to the surgical outcome under study, were followed for 1 year. Patients were grouped into consecutive 2-year age cohorts and matched 1:1 on demographic characteristics, healthcare utilisation, systemic comorbidities, and ocular diagnoses and procedures. Prespecified decade-boundary comparisons were 48/49 versus 50/51, 58/59 versus 60/61, and 68/69 versus 70/71. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for each surgical outcome.</p><p><strong>Results: </strong>Among 8,156,608 eligible patients, 218,816 (2.68%) underwent an included ophthalmic procedure, including 201,591 phacoemulsification procedures. The younger cohort had lower odds of phacoemulsification at each decade boundary: 48/49 vs. 50/51 (OR, 0.956; 95% CI, 0.926-0.986), 58/59 vs. 60/61 (OR, 0.935; 95% CI, 0.909-0.961), and 68/69 vs. 70/71 (OR, 0.903; 95% CI, 0.879-0.927; all P < 0.001). No mid-decade phacoemulsification comparisons were significant. The odds of undergoing MIGS were lower at 48/49 vs. 50/51 (OR, 0.876; 95% CI, 0.814-0.940); no decade-boundary differences were observed for GDI or keratoplasty procedures.</p><p><strong>Conclusions: </strong>Consistent with left-digit bias, surgical frequency for phacoemulsification increased at decade transitions. Clinicians should consider the potential influence of age perception in surgical decision-making.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of a translatable rabbit model for corneal endothelial dysfunction.","authors":"Laura Ortega-Llamas, Mayelín Pérez-Perdomo, Mario Blanco-Blanco, Marta Villalba-González, Ana González-López, David Alba-Molina, Irene Cantarero, Yolanda Jiménez-Gómez, Miguel González-Andrades","doi":"10.1038/s41433-026-04869-4","DOIUrl":"https://doi.org/10.1038/s41433-026-04869-4","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the potential of an adult rabbit descemetorhexis model to recapitulate the damage to the endothelium and Descemet's membrane (DM) seen in humans.</p><p><strong>Methods: </strong>Five corneas of 5 female New Zealand rabbits aged 24-26 months underwent 5-mm descemetorhexis; five unwounded corneas from 5 rabbits served as controls. Animals were followed up for 12-week and post-surgical clinical evaluation was performed using slit-lamp, macro images, and optical coherence tomography (OCT). Histological and immunohistochemical analyses were performed post-sacrifice.</p><p><strong>Results: </strong>Corneal transparency analysed by slit-lamp demonstrated that 2 weeks after descemetorhexis, all adult rabbits displayed grade 3 corneal opacity that was reduced to grade 2-3 and remained at this level until the study endpoint. Corroborating these results, quantitative analysis of macro images showed a significant reduction in corneal transparency during the entire follow-up period, with remarkable effect at 2 weeks (P < 0.05 vs. pre-surgery). Besides, OCT results showed a significant increase in corneal and stromal thickness and fibrosis at 4/8-week post-surgery (P < 0.05 vs. pre-surgery). By 12 weeks, rabbits maintained remarkable fibrosis (P = 0.013 vs. pre-surgery). Finally, histological and immunohistochemical analyses showed that the descemetorhexis group displayed absence of the DM-endothelium complex in the surgical center, which was associated with non-expression of Na⁺/K⁺-ATPase and Zonula occludens-1. An altered collagen matrix with myofibroblasts in the posterior stroma was also found in the surgical center compared with the other analyzed regions in both groups.</p><p><strong>Conclusions: </strong>Our results indicate that descemetorhexis in adult rabbits could be a translatable corneal endothelial dysfunction (CED) model for studying the safety and efficacy of treatments for CED.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinoblastoma management: achieving high standards of care.","authors":"Carol L Shields, Robert J Medina, Salaam Botros, Antonio Bechara Ghobril, Sara E Lally","doi":"10.1038/s41433-026-04939-7","DOIUrl":"https://doi.org/10.1038/s41433-026-04939-7","url":null,"abstract":"<p><p>The current management of retinoblastoma involves chemotherapy by the intravenous, intra-arterial, intravitreous or intra-aqueous delivery routes. These routes can adequately control solid tumour, subretinal seeds, vitreous seeds or aqueous seeds. Intravenous chemotherapy using vincristine, etoposide and carboplatin is commonly used for retinoblastoma control. According to the International Classification of Retinoblastoma, intravenous chemotherapy provides globe salvage with tumour control in 96% of Group A, 90% of Group B and Group C, 68% of Group D and 32% of Group E eyes. Intra-arterial chemotherapy, using melphalan, topotecan and/or carboplatin with delivery from the femoral artery up to the ophthalmic artery to the eye, is particularly used for unilateral retinoblastoma. This alternative has more localised ocular complications but offers more powerful tumour control. Intravitreal chemotherapy, using melphalan and topotecan, can control vitreous seeding, but most specialists employ high-dose topotecan for control of vitreous seeds and some solid tumours and even subretinal seeds. Intra-aqueous chemotherapy, using melphalan or topotecan and can be effective for aqueous seeding. There is still a role for plaque radiotherapy in non-chemotherapy-responsive tumours and enucleation for massive disease that doesn't fully respond to chemotherapy or demonstrates high-risk disease. The management of retinoblastoma has evolved to the current day with several routes of chemotherapy delivery.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal imaging of a rare transient cherry-red spot in incontinentia pigmenti.","authors":"Haonan Ma, Peiquan Zhao, Jie Peng","doi":"10.1038/s41433-026-04909-z","DOIUrl":"https://doi.org/10.1038/s41433-026-04909-z","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subretinal \"napkin-ring\" proliferative vitreoretinopathy in patient with persistent retinal detachment.","authors":"Nan Zhou, Lumin Liang, Wenbin Wei","doi":"10.1038/s41433-026-04753-1","DOIUrl":"https://doi.org/10.1038/s41433-026-04753-1","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors, microbiological profiles, and clinical outcomes of paediatric infectious keratitis: The Midlands Infectious Keratitis Study.","authors":"Haneen Habib Alaali, Khawaja Muhammad Ammar Ali Javed, Alia Z Al-Mousawi, Saba Anwar, Dalia G Said, Harminder S Dua, Saaeha Rauz, Darren S J Ting","doi":"10.1038/s41433-026-04937-9","DOIUrl":"https://doi.org/10.1038/s41433-026-04937-9","url":null,"abstract":"<p><strong>Objectives: </strong>To characterise the clinical features, microbiological profiles, and outcomes of paediatric infectious keratitis (IK).</p><p><strong>Methods: </strong>This retrospective multicentre study included paediatric patients (≤18 years old) who presented with presumed IK and underwent corneal sampling at two UK tertiary ophthalmic centres.</p><p><strong>Results: </strong>We included 42 cases in this study; median age was 13.3 years (IQR 10.1-16.1). Contact lens wear (15, 35.7%) and ocular surface disease (15, 35.7%) were the most common risk factors. Twenty-five (59.5%) cases were microbiologically positive (MP), with Pseudomonas aeruginosa (5, 16.1%), Staphylococcus aureus (5, 16.1%), and Serratia marcescens (5, 16.1%) being the most commonly isolated bacteria. Six (24.0%) cases were caused by polymicrobial infection (≥2 bacteria). Median presenting CDVA was 0.30 logMAR [0.20-1.30] and improved to 0.15 [0.00-0.75] at final follow-up (p < 0.001). Poor visual outcome (final CDVA > 0.6 logMAR) was observed in 11 (26.2%) cases and was associated with worse presenting CDVA (p = 0.010), prior corneal surgery (p = 0.003), and MP status (p = 0.016). Delayed corneal healing (>30 days) occurred in 17 (40.5%) cases. Complications were uncommon, including 3 (7.1%) recurrence, 2 (4.8%) corneal melt, and 1 (2.4%) perforation.</p><p><strong>Conclusions: </strong>Paediatric IK represents an important ocular morbidity in the UK. Contact lens wear was the most common risk factor and was strongly associated with P. aeruginosa infection, highlighting the need for improved awareness, education, and prevention. MP cases were associated with worse visual outcomes and features of greater disease severity. These findings support early recognition and appropriate management to optimise visual outcomes in this population.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silent sinus syndrome: a rare overlooked entity.","authors":"Puja Chowdhury, Md Shahid Alam","doi":"10.1038/s41433-026-04964-6","DOIUrl":"https://doi.org/10.1038/s41433-026-04964-6","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autosomal recessive best disease mimicking chronic central serous chorioretinopathy.","authors":"Ahmet Peçen, Selda Çelik Dülger, Mehmet Yasin Teke","doi":"10.1038/s41433-026-04967-3","DOIUrl":"https://doi.org/10.1038/s41433-026-04967-3","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scoping review of integrated blink analysis technologies for ocular surface diseases.","authors":"Chee Wui Ong, Blanche Xiaohong Lim, Sanjiv K Bhatia, Tjaart van der Walt, Tareq Nabhan, Chris Hong Long Lim","doi":"10.1038/s41433-026-04873-8","DOIUrl":"https://doi.org/10.1038/s41433-026-04873-8","url":null,"abstract":"<p><p>The purpose of this review is to  describe integrated technologies for blink analysis and their utility in evaluating ocular surface diseases. A literature search was conducted using PubMed, Embase, and CENTRAL from January 1, 2000, to August 17, 2025. Search terms included \"Eye Blink\", \"Blink\", \"Blinking\", \"Device\", \"Technology\", \"Appliance\", and \"Application\". We included studies describing the use of integrated technologies to capture and analyse blink metrics for the evaluation of dry eye disease and other ocular surface conditions. Publications describing technical engineering aspects or technologies without evaluation of ocular surface diseases were excluded. Findings from relevant studies were extracted and compared. Of 3275 identified records, 42 met inclusion criteria. We evaluated the use of 9 technologies. These comprised desk-bound devices(Intelligent Vision Sensor, LipiView™, and IDRA) , wearable devices (Wink Glass, Blink-sensing Glasses), and smartphone or computer applications(HealthyRoad, DryEyeRhythm, Dry eye or not? and EyeScore) . LipiView™ and IDRA were most commonly studied. Blink rate and partial blink rate were the most commonly analysed parameters, and DED was the most commonly evaluated ocular surface condition. Consistent with existing literature, studies demonstrated associations between increased partial blink rates and ocular surface compromise. There was however heterogeneity in methods of blink analysis and insufficient validation of the accuracy and diagnostic ability of measured blink parameters for ocular surface conditions. Integrated blink analysis technologies are promising for the assessment of ocular surface diseases. Further studies are needed to evaluate the validity, reliability, and clinical utility of these technologies.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149106237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}