Updates on novel and traditional OCT and OCTA biomarkers in nAMD.

IF 2.8 3区医学 Q1 OPHTHALMOLOGY

Eye Pub Date : 2025-06-01 Epub Date: 2025-04-19 DOI:10.1038/s41433-025-03801-6

Emanuele Crincoli, Maria Cristina Parravano, Riccardo Sacconi, Eliana Costanzo, Maria Sole Polito, Lorenzo Ferro Desideri, Giuseppe Querques

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引用次数: 0

Abstract

Predictivity of optical coherence tomography (OCT) examination for the development of neovascular age-related macular degeneration (nAMD) was demonstrated to be superior compared to other methods, suggesting it as an elective method for screening purposes. Moreover, OCT and OCT angiography (OCTA) have enabled us to provide accurate prognostic information to nAMD patients. Along with well-known prognostic biomarkers, such as the presence of reticular pseudodrusen, the volume of the pigment epithelial detachment (PED), subretinal fluid (SRF), intraretinal fluid (IRF) and hyperreflective foci (HRF), emerging parameters show promising results and may allow a further refinement of prediction and customization of treatment and follow up strategies. This review of the literature discusses the main OCT and OCTA biomarkers reported in literature for nAMD, with a special focus on recent updates on the subject. Future perspectives of clinical applications include the development of artificial intelligence models considering all the described biomarkers to allow automatic and detailed characterization of each lesion based on imaging information.

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nAMD中新型和传统OCT和OCTA生物标志物的最新进展。

与其他方法相比，光学相干断层扫描（OCT）检查对新生血管性年龄相关性黄斑变性（nAMD）发展的预测性优于其他方法，表明它是一种选择性的筛查方法。此外，OCT和OCT血管造影（OCTA）使我们能够为nAMD患者提供准确的预后信息。随着众所周知的预后生物标志物，如网状假性囊肿的存在，色素上皮脱离（PED）的体积，视网膜下液（SRF），视网膜内液（IRF）和高反射灶（HRF），新出现的参数显示出有希望的结果，并可能允许进一步改进预测和定制治疗和随访策略。这篇文献综述讨论了文献中报道的nAMD的主要OCT和OCTA生物标志物，并特别关注了该主题的最新进展。临床应用的未来前景包括考虑所有描述的生物标志物的人工智能模型的发展，以允许基于成像信息对每个病变进行自动和详细的表征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eye 医学-眼科学

CiteScore

6.40

自引率

5.10%

发文量

481

审稿时长

3-6 weeks

期刊介绍： Eye seeks to provide the international practising ophthalmologist with high quality articles, of academic rigour, on the latest global clinical and laboratory based research. Its core aim is to advance the science and practice of ophthalmology with the latest clinical- and scientific-based research. Whilst principally aimed at the practising clinician, the journal contains material of interest to a wider readership including optometrists, orthoptists, other health care professionals and research workers in all aspects of the field of visual science worldwide. Eye is the official journal of The Royal College of Ophthalmologists. Eye encourages the submission of original articles covering all aspects of ophthalmology including: external eye disease; oculo-plastic surgery; orbital and lacrimal disease; ocular surface and corneal disorders; paediatric ophthalmology and strabismus; glaucoma; medical and surgical retina; neuro-ophthalmology; cataract and refractive surgery; ocular oncology; ophthalmic pathology; ophthalmic genetics.