Eye最新文献

{"title":"The impact of extended reality simulators on ophthalmic surgical training and performance: a systematic review and meta-analysis of 17,623 eyes.","authors":"Lucy Yang, Abdullah Al-Ani, Mohamed S Bondok, Patrick Gooi, Helen Chung","doi":"10.1038/s41433-025-03722-4","DOIUrl":"https://doi.org/10.1038/s41433-025-03722-4","url":null,"abstract":"<p><strong>Background: </strong>Extended reality (XR) simulators, including virtual reality and augmented reality, hold significant promise for enhancing surgical training by providing trainees with a controlled practice environment. This is particularly vital in microsurgery, where the steep learning curve and the challenge of mastering surgical skills are significant. Despite notable advancements in XR technology, its role in ophthalmic surgical training remains uncertain.</p><p><strong>Methods: </strong>In our systematic review and meta-analysis, eight electronic databases were searched, and studies were evaluated against predefined criteria. Data extraction and random-effects meta-analysis assessed the odds ratio (OR) for posterior capsular rupture (PCR), an important surgical complication.</p><p><strong>Results: </strong>A meta-analysis of 17,623 eyes that underwent cataract surgery across seven studies revealed a significant decrease in PCR post-Eyesi practice, with low heterogeneity across studies (OR = 0.71, 95% CI = 0.60-0.85, I² = 9%). Studies that predominantly utilized XR for cataract surgery training (84%) consistently improved surgical outcomes by reducing complications such as PCR, retained lens material, and aphakia. XR training also significantly improved operating scores (p < 0.05), self-efficacy (p < 0.01), and non-dominant hand dexterity (p < 0.01). Of the 25 studies in this review, 22 (88%) found overall XR training benefits.</p><p><strong>Conclusions: </strong>XR simulators enhance ophthalmic surgical training by reducing complications like PCR, and improving surgical performance, self-efficacy, and non-dominant hand dexterity. These findings challenge conventional training methods and advocate for integrating XR into residency curricula to optimize learning and patient outcomes.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flow and ischemic changes in retina and choroid across diabetic retinopathy spectrum: a SS-OCTA study.","authors":"Qianhui Yang, Kelvin Y C Teo, Yueheng Hong, Bingyao Tan, Leopold Schmetterer, Chui Ming Gemmy Cheung, Tien Yin Wong, Gavin Tan Siew Wei","doi":"10.1038/s41433-025-03639-y","DOIUrl":"10.1038/s41433-025-03639-y","url":null,"abstract":"<p><strong>Purpose: </strong>To examine changes in retinal and choroidal vasculature in diabetes mellitus across the range of diabetic retinopathy (DR) severities using optical coherence tomography angiography (OCTA) and compare the patterns of vascular changes.</p><p><strong>Methods: </strong>We conducted a cross-sectional study enrolling 296 patients (498 eyes) with diabetes mellitus. Swept-Source OCT Angiography variables in both retina and choroid, including perfusion density (PD), vessel density (VD), large vessel density (LVD) in both superficial and deep layer of retina and CC flow voids (FD) density of the choroid were quantified. Correlations between OCTA parameters and DR severity, visual acuity and studied factors were performed.</p><p><strong>Results: </strong>Totally 498 eyes including 176 had no DR, 160 had mild NPDR, 98 had moderate NPDR, 11 had severe NPDR, 41 had PDR with PRP, and 12 had PDR without PRP. Choriocapillaris (CC) flow voids density increased with increasing DR severity (17.06% vs 17.41% vs 17.60% vs 17.62% vs 18.05% vs 18.41%, p-trend = 0.0004), FAZ area increased with DR severity in both superficial and deep layer (superficial layer p trend=0.0027; deep layer p trend=0.0022). Visual acuity correlated negatively with CC flow voids (Pearson's ρ = 0.09, p = 0.04) and superficial FAZ area (Pearson's ρ = 0.22, p < 0.001), while inversely correlated with SCP PD (Pearson's ρ = -0.15, p < 0.001) and VD (Pearson's ρ = -0.15, p < 0.001), as well as DCP PD (Pearson's ρ = -0.21, p < 0.001) and VD (Pearson's ρ = -0.19, p < 0.001).</p><p><strong>Conclusion: </strong>Choriocapillaris ischemia increased, FAZ area enlarged, and total retina perfusion density decreased with increasing DR severity. The deep layer and large vessels may change in early stage before DR progresses to PDR. More ischemia and vessel tortuosity are correlated with worse visual acuity and higher HbA1c level. OCTA can be utilized to detect both large and small vascular changes in both the retina and choroid in DR patients.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing safety and efficacy of Bevacizumab, Ranibizumab and Ranibizumab biosimilar in Retinopathy of prematurity.","authors":"Puja Maitra, Sujay Jaju, Kushal U Agrawal, Abhishek Das, Prema Subramaniam, Narendran Venkatapathy, Parag K Shah","doi":"10.1038/s41433-025-03735-z","DOIUrl":"10.1038/s41433-025-03735-z","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the safety and efficacy of Bevacizumab, Ranibizumab and Ranibizumab biosimilar in treatment of Retinopathy of prematurity (ROP) METHODS: Retrospective study that included newborns with type 1 ROP who received intravitreal Bevacizumab (Avastin) or Ranibizumab (Accentrix) or Ranibizumab biosimilar (Razumab). Babies were followed up as per protocol and retreatment with laser or repeat anti vascular endothelial growth factor (VEGF) was done in case of reactivation and surgery in case of progression to traction. Outcome measures include need for retreatment, proportion of eyes achieving vascularization up to ora and adverse events RESULTS: 148 eyes of 75 babies, received intravitreal injection of which 139 eyes of 70 babies were included in our analysis. 68 eyes received bevacizumab (IVB), 31 eyes received Accentrix (IVA), 40 eyes received Razumab(IVR). The rate of retreatment was 17.6%, 32.2% and 25% for IVB, IVA and IVR respectively (p = 0.1). IVB group showed a significantly delayed reactivation (p < 0.001), while Ranibizumab and its biosimilar Razumab were comparable (p = 0.17). Vascularization up to ora was observed in 60%, 61% and 50% eyes (p = 0.76) at a median of 27, 28 and 24 weeks post-treatment (p = 0.09) in IVB, IVA and IVR groups respectively. No eyes developed intraocular inflammation or cataract.</p><p><strong>Conclusion: </strong>All three drugs were similar in their efficacy and safety profile with bevacizumab showing a later reactivation.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral choroidal osteoma.","authors":"Chitaranjan Mishra, Aditya Maitray, Sagnik Sen, Naresh Babu Kannan","doi":"10.1038/s41433-025-03675-8","DOIUrl":"https://doi.org/10.1038/s41433-025-03675-8","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dark choroid sign in Stargardt disease.","authors":"Meri Debbarma, Muthukrishnan Vallinayagam, Chitaranjan Mishra, Naresh Babu Kannan","doi":"10.1038/s41433-025-03676-7","DOIUrl":"https://doi.org/10.1038/s41433-025-03676-7","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of fundus changes in healthy school-aged children and adolescents aged 5-19 years in Beijing.","authors":"Haowen Li, Jingying Xiu, Wei Zhang, Jie Xu, Yang Li, Wenbin Wei","doi":"10.1038/s41433-025-03711-7","DOIUrl":"https://doi.org/10.1038/s41433-025-03711-7","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate and analyse the epidemiological characteristics of fundus changes among school-aged children, and to explore its correlation with myopia.</p><p><strong>Methods: </strong>School-aged children from 20 schools in Beijing were screened under cooperation between Beijing Tongren Hospital and Beijing Daxing District Education Commission from September 2022 to March 2023. Uncorrected non-dilated visual acuity and refraction were examined. Fundus photographs of both eyes were evaluated by skilled clinicians. The differences in fundus changes among demographic characteristics were compared.</p><p><strong>Results: </strong>A total of 15,031 participants (30,062 eyes) from 20 schools were included, including 14 elementary schools and 6 secondary schools. The prevalence of fundus changes was 3.3%, 5.9%, and 6.2% for elementary schools, junior and senior high schools, respectively. The top five fundus changes comprised of myopia-related fundus changes (2.0%), physiologic enlarged cup (1.2%), suspected glaucoma (0.3%), myelinated nerve fibres (0.1%), and papillomacular bundle defect (PMBD) (0.1%). Males exhibited a 7.627 and 1.388 times higher risk of developing PMBD and physiological enlarged cup (p < 0.01, respectively). Eyes with myopia-related fundus changes and suspected glaucoma exhibited larger interpupillary distance, longer eye axis, worse visual acuity and lower spherical equivalent.</p><p><strong>Conclusions: </strong>The prevalence of fundus changes varies with school ages, gender, and myopia status. The prevalence of myopia-related fundus changes, suspected glaucoma, and other retinopathy or optic neuropathy escalates with increasing age and the severity of myopia. The pathological myopia is scarce in children. Male gender is a risk factor for PMBD and is also modestly associated with physiological enlarged cup.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of pediatric and adult optic neuritis in the United States from 2016 to 2023.","authors":"Nadia J Abbass, Jacqueline K Shaia, Priya Shukla, Devon Cohen, David C Kaelber, Katherine E Talcott, Rishi P Singh","doi":"10.1038/s41433-025-03683-8","DOIUrl":"https://doi.org/10.1038/s41433-025-03683-8","url":null,"abstract":"<p><strong>Background/objectives: </strong>Data on the prevalence of optic neuritis (ON) is limited with reported rates between 5.5 and 115.3 per 100,000. The US data is even more limited with the largest study performed in a single county, finding a prevalence of 115.3. This study aims to fill the gap in US data on ON.</p><p><strong>Methods: </strong>This (2016-2023) cross-sectional study included patients with ICD-10 codes of retrobulbar neuritis, other ON, unspecified ON, and excluded those with optic papillitis, nutritional optic neuropathy, toxic optic neuropathy. Data was collected through a series of queries in a large platform (TriNetX, LLC) containing EHR data from over 113 million patients.</p><p><strong>Results: </strong>In 2023, the prevalence of ON was 51.6 per 100,000 people in the overall population. Females had a 1.31 (95% CI, 1.27-1.36) increased odds of disease compared to males. Investigating racial and ethnic breakdown, the highest prevalence was found in the Black population (57.8/100,000) (OR 1.06 (1.01-1.10)), followed by the White (54.7/100,000) (REF) and then Hispanic or Latino populations (45.8/100,000) (OR 0.84 (0.79-0.89)) in 2023. Stratified by age, those ages 45-54 had the highest prevalence (71.3/100,000). The prevalence of ON increased 1.08 (1.05-1.10) times from 2016-2023, with the greatest increase seen in the Hispanic population. Significant increases in prevalence were also seen in the 0-14, 15-24, and 25-34 age groups.</p><p><strong>Discussion: </strong>Racial, ethnic and sex disparities are apparent in the distribution of ON, with Black individuals and females affected most often, and an increasing prevalence seen in the Hispanic population. Younger subpopulations also demonstrated significant increases, warranting additional investigation.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related macular degeneration in 2025- opportunities and challenges.","authors":"Chui Ming Gemmy Cheung","doi":"10.1038/s41433-025-03710-8","DOIUrl":"https://doi.org/10.1038/s41433-025-03710-8","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: \"Benchmarking the performance of large language models in uveitis: a comparative analysis of ChatGPT-3.5, ChatGPT-4.0, Google Gemini, and Anthropic Claude3\".","authors":"Xiao Luo, Cheng Tang, Jin-Jin Chen, Jin Yuan, Jin-Jin Huang, Tao Yan","doi":"10.1038/s41433-025-03736-y","DOIUrl":"https://doi.org/10.1038/s41433-025-03736-y","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep and mood in central serous chorioretinopathy.","authors":"Yunfei Yang, Victoria S Foster, Sophie Marlowe, Sarah R Stevenson, Iona Alexander, Russell G Foster, Susan M Downes","doi":"10.1038/s41433-025-03688-3","DOIUrl":"https://doi.org/10.1038/s41433-025-03688-3","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the impact of central serous chorioretinopathy on sleep and mood in patients with acute and chronic central serous chorioretinopathy.</p><p><strong>Methods: </strong>This cross-sectional study compared sleep and mood differences between central serous chorioretinopathy and control patients recruited from Ophthalmology clinics at the John Radcliffe Hospital, Oxford between 2012 and 2020. Data including visual acuity, type of central serous chorioretinopathy (acute or chronic; aCSC/cCSC), sex, and chronotype were obtained. Sleep quality was measured using the Pittsburgh Sleep Quality Index (PSQI); the Hospital Anxiety and Depression Scale (HADS) was used to evaluate anxiety (HADS-A) and depression (HADS-D).</p><p><strong>Results: </strong>A total of 247 age matched controls and 109 patients with central serous chorioretinopathy participated. There were no significant differences in PSQI or HADs (P > 0.05) between the two groups. Females exhibited significantly higher PSQI scores than males both for control and central serous chorioretinopathy groups (P < 0.05). Within the central serous chorioretinopathy group, 88 (81%) had chronic central serous chorioretinopathy and 21 (19%) had acute central serous chorioretinopathy, and an increase in daytime dysfunction was seen in the acute phenotype compared to chronic (P = 0.018).</p><p><strong>Conclusion: </strong>In our study, no significant differences in sleep quality or mood scores were identified in central serous chorioretinopathy patients, when compared to controls. Worsened sleep for females was present when compared to males, both in central serous chorioretinopathy and control groups. Within central serous chorioretinopathy groups, worsened daytime function was observed in acute versus chronic - a larger study would help distinguish the effect of chronicity on sleep.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}