IF 4.4 3区医学

Eye Pub Date : 2026-09-29 DOI: 10.1038/s41433-026-04950-y

Sunita Chaurasia, Rashmi Krishnamurthy, Soumayava Basu, Muralidhar Ramappa

引用次数: 0

Outcomes of switching from faricimab to aflibercept 8 mg in nAMD: a real-world case series. 在nAMD中从faricimab切换到afliberept 8mg的结果：一个真实世界的病例系列。

IF 4.4 3区医学

Eye Pub Date : 2026-09-29 DOI: 10.1038/s41433-026-04947-7

Cristian Metrangolo, Paolo Radice, Manuela Mambretti, Giorgio Bonello, Alessandro Tonini, Gaia Rossi, Simone Donati

引用次数: 0

Expanding the genotype-phenotype spectrum of autosomal recessive bestrophinopathy: a clinicogenetic report of Filipino siblings with compound heterozygous BEST1 variants. 扩展常染色体隐性双相遗传病的基因型-表型谱：菲律宾兄弟姐妹复合杂合BEST1变异的临床遗传学报告。

IF 4.4 3区医学

Eye Pub Date : 2026-09-29 DOI: 10.1038/s41433-026-04948-6

Raphael D Gumafelix, Kristine D Corpus-Velasquez, Manuel Benjamin B Ibanez

引用次数: 0

A rare association of microspherophakia, iridofundal coloboma and goniodysgenesis. 微球眼、虹膜基底缺损和性腺发育的罕见关联。

IF 4.4 3区医学

Eye Pub Date : 2026-09-29 DOI: 10.1038/s41433-026-04931-1

Anand Kumar Pathak, Anurag Kumar, Viney Gupta

引用次数: 0

Effects of narrow macular staphyloma, male sex and younger age on the risk of lacquer cracks in patients with high myopia. 窄性黄斑葡萄肿、男性、低龄对高度近视患者漆膜开裂风险的影响。

IF 4.4 3区医学

Eye Pub Date : 2026-09-29 DOI: 10.1038/s41433-026-04962-8

Kyoko Ohno-Matsui, Yijin Wu, Koju Kamoi, Shu-I Pao

{"title":"Effects of narrow macular staphyloma, male sex and younger age on the risk of lacquer cracks in patients with high myopia.","authors":"Kyoko Ohno-Matsui, Yijin Wu, Koju Kamoi, Shu-I Pao","doi":"10.1038/s41433-026-04962-8","DOIUrl":"https://doi.org/10.1038/s41433-026-04962-8","url":null,"abstract":"Background: Lacquer cracks (LCs) are linear breaks in Bruch's membrane in highly myopic eyes; however, their risk factors remain fully unclarified. We determined associations between age, staphyloma type and LC risk in highly myopic eyes.Methods: This retrospective study reviewed 226 eyes of 141 patients with high myopia (refractive error < -8 dioptres or axial length ≥26.5 mm), including 64 eyes with LCs and 162 eyes without LCs.Results: Male sex (odds ratio [OR] = 2.962, 95% confidence interval [CI]: 1.343-6.533), higher myopia (refractive error < -12.25 dioptres [a median refractive error in all eyes]) (OR = 7.029, 95% CI: 2.957-16.708) and narrow macular staphyloma (OR = 3.212, 95% CI: 1.048-9.844) were associated with increased risk of LCs, while older age (OR = 0.941, 95% CI: 0.893-0.992) was associated with decreased risk of LCs. Narrow macular staphyloma-related LC risk was observed in the younger age subgroup (OR = 5.354, 95% CI: 0.948-30.244) but not observed in the older age subgroup (OR = 1.837, 95% CI: 0.371-9.084). Male sex-related LC risk was observed in the older age subgroup (OR = 6.929, 95% CI: 2.085-23.024) but not observed in the younger age subgroup (OR = 1.671, 95% CI: 0.558-5.005).Conclusion: Narrow macular staphyloma, male sex and younger age are predictors of LCs in patients with high myopia. Younger age with narrow macular staphyloma or older age with male sex showed synergistic effects on LC risk. This suggests that these high-risk patients require regular monitoring and frequent ophthalmic evaluations to ensure a good prognosis.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrawidefield OCT angiography in laser-treated retinopathy of prematurity. 激光治疗早产儿视网膜病变的超宽视场OCT血管造影。

IF 4.4 3区医学

Eye Pub Date : 2026-09-29 DOI: 10.1038/s41433-026-04940-0

Zhenquan Wu, Xinyu Zhao, Guoming Zhang

引用次数: 0

Pseudo-penetrating coiled metallic foreign body in the paediatric lid fornix. 小儿眼睑穹窿内假穿透性盘状金属异物。

IF 4.4 3区医学

Eye Pub Date : 2026-09-29 DOI: 10.1038/s41433-026-04956-6

Aahan D Shah, Ashish Sunkarapalli, Jaspreet Sukhija

引用次数: 0

The Great unveiling: Giant RPE rip behind a bullous serous detachment. 伟大的揭秘：巨大的RPE撕裂背后的大疱严重脱离。

IF 4.4 3区医学

Eye Pub Date : 2026-09-28 DOI: 10.1038/s41433-026-04915-1

MuthuKrishnan V, Ramya Jayasingh Rajan, Naresh Babu Kannan

引用次数: 0

International practice patterns and beliefs concerning intravenous methylprednisolone and low-dose aspirin in giant cell arteritis. 关于静脉注射甲基强的松龙和小剂量阿司匹林治疗巨细胞动脉炎的国际实践模式和观点。

IF 4.4 3区医学

Eye Pub Date : 2026-09-28 DOI: 10.1038/s41433-026-04912-4

Mats Junek, Susan P Mollan, Jean-Paul Makhzoum

{"title":"International practice patterns and beliefs concerning intravenous methylprednisolone and low-dose aspirin in giant cell arteritis.","authors":"Mats Junek, Susan P Mollan, Jean-Paul Makhzoum","doi":"10.1038/s41433-026-04912-4","DOIUrl":"https://doi.org/10.1038/s41433-026-04912-4","url":null,"abstract":"Background: The use of intravenous glucocorticoids (IVGCs) and low-dose acetylsalicylic acid (ASA) in giant cell arteritis (GCA) remains controversial, with limited evidence and heterogeneous guideline recommendations. We conducted an international survey to characterise current practice patterns, clinical equipoise, and trial design priorities.Methods: A cross-sectional online survey was distributed internationally to clinicians involved in GCA care between December 2025 and January 2026. Questions addressed demographics, prescribing practices, motivations and barriers, and preferred outcomes for clinical trials evaluating ASA and IVGCs. Descriptive analyses were performed.Results: A total of 155 respondents from five continents were included, predominantly rheumatologists (51.0%) and ophthalmology specialists (33.5%). ASA was initiated in a minority of patients (median 15%), primarily for stroke prevention, with major barriers including lack of disease-specific evidence and bleeding risk. Clinical equipoise regarding ASA was reported by 69.5%, and 71.6% expressed interest in trial participation. IVGCs were widely used for visual involvement, particularly permanent vision loss, though substantial variability existed in indications and dosing. Equipoise for IV versus oral glucocorticoids was reported by 68.5%, with strong interest in trial participation (71.2%). Across both interventions, respondents prioritised clinically meaningful outcomes such as stroke, contralateral vision loss, and major adverse cardiovascular events.Conclusions: This international survey demonstrates significant heterogeneity and persistent clinical uncertainty in the use of ASA and IVGCs in GCA. High levels of equipoise and willingness to participate in trials highlight the urgent need for randomised studies to inform evidence-based practice.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bent ab interno needle goniotomy versus gonioscopy-assisted transluminal trabeculotomy in primary open angle glaucoma: a randomised clinical trial, 24-month outcomes. 原发性开角型青光眼的弯腹针间性腺切开术与性腺镜辅助下的腔内小梁切开术：一项24个月的随机临床试验

IF 4.4 3区医学

Eye Pub Date : 2026-09-28 DOI: 10.1038/s41433-026-04902-6

Gabriel Ayub, Vital Paulino Costa

{"title":"Bent ab interno needle goniotomy versus gonioscopy-assisted transluminal trabeculotomy in primary open angle glaucoma: a randomised clinical trial, 24-month outcomes.","authors":"Gabriel Ayub, Vital Paulino Costa","doi":"10.1038/s41433-026-04902-6","DOIUrl":"https://doi.org/10.1038/s41433-026-04902-6","url":null,"abstract":"Background: To evaluate and compare 24-month outcomes of Bent Ab interno Needle Goniotomy (BANG) and Gonioscopy-Assisted Transluminal Trabeculotomy (GATT) in pseudophakic primary open angle glaucoma (POAG) patients.Methods: Parallel, double-arm, 1:1 ratio, single masked, randomised clinical trial. Pseudophakic POAG eyes with mild to moderate glaucoma and intraocular pressure (IOP) ≥ 18 mmHg under a maximum of 3 antiglaucoma medications were randomised to BANG or GATT. Main outcomes were mean IOP reduction from baseline and surgical success at 24-months. Complete surgical success was defined as IOP ≤ 18 mmHg and 20% IOP reduction from baseline under no medication. Qualified success followed the same parameters, but allowed the use of medication. Additional glaucoma surgery, clinical hypotony or loss of light perception were considered failures.Results: A total of 45 eyes (22 BANG and 23 GATT) were included. At endpoint, in the BANG and GATT groups, mean IOPs were reduced by 16.0% (p < 0.01) and 22.44% (p < 0.01) (time-group analysis: p = 0.048), whereas medication was reduced by 6.22% (p = 0.89) and 69.78% (p < 0.01) (time-group analysis: p < 0.01), respectively. GATT eyes presented a higher number of medication-free eyes (11 vs. 2, p < 0.01) and IOPs in the low-teens (4 vs. 0, p = 0.02). GATT eyes achieved higher rates of complete (55.0% vs. 4.5%, p < 0.01) and qualified success (64.7% vs. 11.4%, p < 0.01). Additional surgery was needed in 3 (13.63%) BANG eyes and 4 (18.18%) GATT eyes (p = 1.0).Conclusion: GATT eyes achieved higher success rates, lower mean IOPs and required less antiglaucoma medication than BANG eyes after 24-months. Both techniques showed a good safety profile and low need for additional surgery.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":4.4,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149074145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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