IF 2.8 3区医学

Eye Pub Date : 2025-05-13 DOI: 10.1038/s41433-025-03834-x

Maria S Varughese, Ananth U Nayak, Louise Payne, Lakshminarayanan Varadhan

引用次数: 0

Causal relationships between depression, anxiety, and myopia: a two-sample Mendelian randomization study. 抑郁、焦虑和近视之间的因果关系：一项双样本孟德尔随机研究。

IF 2.8 3区医学

Eye Pub Date : 2025-05-13 DOI: 10.1038/s41433-025-03841-y

Shengsong Xu, Xiao Wang, Jinyi Xu, Xianghua Tang, Wenlong Hao, Chuqi Xiang, Xingyu Lei, Mengyi Wang, Xiao Yang

{"title":"Causal relationships between depression, anxiety, and myopia: a two-sample Mendelian randomization study.","authors":"Shengsong Xu, Xiao Wang, Jinyi Xu, Xianghua Tang, Wenlong Hao, Chuqi Xiang, Xingyu Lei, Mengyi Wang, Xiao Yang","doi":"10.1038/s41433-025-03841-y","DOIUrl":"10.1038/s41433-025-03841-y","url":null,"abstract":"Objectives: To investigate the causal relationship between depression, anxiety, and myopia.Methods: The multivariable Mendelian randomization (MR) design using summary statistics from independent genome-wide association studies (GWAS) was employed. The anxiety and depression, were used as exposures, and myopia was used as the outcome. Genetic variants associated with depression were derived using GWAS summary statistics from the FinnGen consortium database. Genetic variants associated with anxiety were derived from the Psychiatric Genomics consortium. The inverse-variance-weighted method was the main applied analytic tool and was complemented with comprehensive sensitivity analyses.Results: A total of 21, 10 SNPs were selected as instrumental variables for depression and anxiety, respectively. Based on the IVW analysis, both depression (OR = 1.010, 95% CI = 1.002-1.018, P = 0.016) and anxiety (OR = 1.083, 95%CI = 1.022-1.149, P = 0.008) increased the risk of myopia. After adjusting in the multivariable MR, the IVW and Egger methods indicated that depression (OR = 1.004, 95%CI = 1.000-1.008, P = 0.030) or anxiety (OR = 1.004, 95%CI = 1.001-1.008, P = 0.026) was still associated with elevated risks of myopia.Conclusions: The current study identified a causal relationship between anxiety, depression, and an increased risk of myopia. These observations suggest that when developing strategies to control myopia, it is also important to focus on the mental health of children. Further detailed research is needed to fully understand this issue.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Steatocystoma of the Eyelid. 眼睑脂肪囊瘤。

IF 2.8 3区医学

Eye Pub Date : 2025-05-12 DOI: 10.1038/s41433-025-03820-3

Bipasha Mukherjee

引用次数: 0

Honeycomb corneal oedema after rho-kinase inhibitor use. 使用rho激酶抑制剂后蜂窝状角膜水肿。

IF 2.8 3区医学

Eye Pub Date : 2025-05-12 DOI: 10.1038/s41433-025-03842-x

Gonzalo Roig-Ferreruela, Marc Bautista-Cortiella, José Vicente Piá-Ludeña

引用次数: 0

Visual outcome following initiation of first injection versus after three monthly doses of aflibercept 2 mg for treatment naïve age-related macular degeneration to inform clinical trial designs: PRECISE Report No. 6. 第一次注射后的视力结果与三个月剂量2毫克阿伯西普治疗naïve年龄相关性黄斑变性临床试验设计：精确报告6号。

IF 2.8 3区医学

Eye Pub Date : 2025-05-12 DOI: 10.1038/s41433-025-03797-z

Swati Chandak, Sarega Gurudas, Raheeba Pakeer Muhammed, Ayse Keskin, Sridevi Thottarath, Faruque Ghanchi, Anna Grabowska, Stephen James Talks, Ian Pearce, Martin McKibbin, Ajay Kotagiri, Geeta Menon, Benjamin J L Burton, Richard Gale, Sobha Sivaprasad

{"title":"Visual outcome following initiation of first injection versus after three monthly doses of aflibercept 2 mg for treatment naïve age-related macular degeneration to inform clinical trial designs: PRECISE Report No. 6.","authors":"Swati Chandak, Sarega Gurudas, Raheeba Pakeer Muhammed, Ayse Keskin, Sridevi Thottarath, Faruque Ghanchi, Anna Grabowska, Stephen James Talks, Ian Pearce, Martin McKibbin, Ajay Kotagiri, Geeta Menon, Benjamin J L Burton, Richard Gale, Sobha Sivaprasad","doi":"10.1038/s41433-025-03797-z","DOIUrl":"https://doi.org/10.1038/s41433-025-03797-z","url":null,"abstract":"Purpose: To study the outcome of the first dose versus three monthly doses of 2 mg aflibercept in the initiation phase of neovascular age-related macular degeneration (nAMD) to inform future clinical trial design on novel durable agents. These agents may take time to act and so initial dosing with aflibercept 2 mg is required for immediate effect.Methods: Visual acuity (VA) outcomes and associations with baseline VA and OCT characteristics were analysed using logistic regression via generalised estimating equations. In addition, VA outcomes based on different combinations of eligibility criteria were assessed.Results: A total of 1999 eyes of 1862 patients were analysed. The mean age was 79.3 (SD 7.8) years. The mean presenting VA was 58.0 (SD 14.5) ETDRS letter score. A statistical difference in VA was found after first injection (visit 2, 61.6, SD 14.3 ETDRS letter score) and after three monthly injections (visit 4, 62.7, SD 14.9 ETDRS letter score) (P < 0.001). Lower baseline VA and OCT features suggestive of structural changes in the fovea are associated with lower VA after both first and post- initiating doses. Eyes with baseline VA > / = 54 letters alone had similar VA outcomes to eyes with both VA > / = 54 letters and central subfield thickness (CST) of <500 microns.Conclusion: Mean VA outcomes after three monthly anti-VEGF injections are significantly better than after the first initiating dose. However, baseline OCT characteristics associated with VA in these two timepoints are not clinically different.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lower incidence of diabetic retinopathy and worsening events after phentermine assisted weight loss across a large U.S. cohort. 在美国一项大型队列研究中，芬特明辅助减肥后糖尿病视网膜病变和恶化事件的发生率较低。

IF 2.8 3区医学

Eye Pub Date : 2025-05-10 DOI: 10.1038/s41433-025-03818-x

Madhukar Kumar, Nadia J Abbass, Matthew W Russell, Nikhil Das, Rishi P Singh, Katherine E Talcott

{"title":"Lower incidence of diabetic retinopathy and worsening events after phentermine assisted weight loss across a large U.S. cohort.","authors":"Madhukar Kumar, Nadia J Abbass, Matthew W Russell, Nikhil Das, Rishi P Singh, Katherine E Talcott","doi":"10.1038/s41433-025-03818-x","DOIUrl":"https://doi.org/10.1038/s41433-025-03818-x","url":null,"abstract":"Background/objectives: Medication assisted weight loss for treatment of obesity has rapidly increased. The effect of this treatment with phentermine on diabetic retinopathy (DR) is underexplored.Subjects/methods: Retrospective cohort study. The U.S. Collaborative Network of the TriNetX platform was queried for patients diagnosed with overweight and obesity and prescription of phentermine. Patients were propensity score matched across baseline demographics and systemic risk factors at the time of medication initiation and compared to those diagnosed with overweight and obesity without usage of weight loss medications, identifying 26,611 patients per cohort after propensity score matching. Risk ratios (RR) of incident DR and related diagnoses or procedural codes found after the medication initiation date for pertinent disease worsening and treatment metrics were assessed.Results: Phentermine usage was found to be associated with reduced future risk of a new diagnosis of DR with macular oedema (RR 0.462; (95% CI 0.372-0.573), P < 0.001), mild non-proliferative diabetic retinopathy (NPDR) (RR 0.621 (0.508, 0.760), P < 0.001), moderate NPDR (RR 0.567 (0.402, 0.799), P < 0.001), severe NPDR (RR 0.477 (0.233, 0.981), P = 0.003), proliferative diabetic retinopathy (PDR) (RR 0.451 (0.323, 0.629), P < 0.001), vitreous haemorrhage (RR 0.347 (0.200, 0.602), P < 0.001), need for intravitreal anti-VEGF injection (RR: 0.530 (0.354, 0.793), P < 0.001).Conclusion: The present analysis suggests that phentermine usage is associated with a decreased risk of diabetic macular oedema, NPDR, PDR, and worsening events.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term outcomes of the observe-and-plan regimen in treating neovascular age-related macular degeneration: a retrospective real-life analysis. 观察和计划方案治疗新生血管性年龄相关性黄斑变性的长期结果：回顾性现实分析。

IF 2.8 3区医学

Eye Pub Date : 2025-05-10 DOI: 10.1038/s41433-025-03830-1

M Sherif, Y Derradji, A Safi, I Mantel

{"title":"Long-term outcomes of the observe-and-plan regimen in treating neovascular age-related macular degeneration: a retrospective real-life analysis.","authors":"M Sherif, Y Derradji, A Safi, I Mantel","doi":"10.1038/s41433-025-03830-1","DOIUrl":"https://doi.org/10.1038/s41433-025-03830-1","url":null,"abstract":"Background/objectives: This study aimed to evaluate the long-term (7 years) outcome of visual acuity in patients with neovascular age-related macular degeneration (nAMD) treated with anti-vascular endothelial growth factor (VEGF) agents following the observe-and-plan regimen.Subjects/methods: A total of 195 eyes from 181 patients with nAMD (mean age 79.5 ± 6.9 years), with a mean follow-up duration of 66 ± 37 months, treated with intravitreal anti-VEGF (ranibizumab or aflibercept) were included in this retrospective study. The principles of the observe-and-plan regimen were followed, with follow-up exceeding 3 years in real-life settings. Data collected included visual acuity (VA), number of injections and visits, central retinal thickness, and any complications over 7 years from baseline.Results: The mean baseline VA was 63 ± 17 Early Treatment of Diabetic Retinopathy Study letters (Snellen equivalent 20/63), improving to 73 ± 14 at year 1. The initial visual gain was slightly reduced with a final mean VA of 70 ± 18 letters (Snellen equivalent 20/40) at year 7. The mean central macular thickness decreased significantly from 375 ± 129 at baseline to 276 ± 75 at year 1 and to 279 ± 87 at year 7. The mean annual number of injections decreased from 8.7 ± 3.2 in year 1 to 6.7 ± 3.7 in year 2 and to 5.5 ± 2.8 in year 7. The mean annual number of visits remained constant throughout, with 4.1 ± 1.3 visits in year 1 and 4.7 ± 1.7 in year 7.Conclusions: The observe-and-plan regimen was very efficient for treating nAMD in real-life settings, reducing the clinical burden on the medical system and patients, with excellent functional and structural long-term results.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between leukocyte telomere length and incident glaucoma: A prospective UK biobank study. 白细胞端粒长度与青光眼的关系：一项前瞻性英国生物库研究。

IF 2.8 3区医学

Eye Pub Date : 2025-05-07 DOI: 10.1038/s41433-025-03838-7

Jun Yu, Yuzhou Zhang, Chi Pui Pang, Clement C Tham, Jason C Yam, Li Jia Chen

{"title":"Association between leukocyte telomere length and incident glaucoma: A prospective UK biobank study.","authors":"Jun Yu, Yuzhou Zhang, Chi Pui Pang, Clement C Tham, Jason C Yam, Li Jia Chen","doi":"10.1038/s41433-025-03838-7","DOIUrl":"https://doi.org/10.1038/s41433-025-03838-7","url":null,"abstract":"Background: Leukocyte telomere length (LTL) has been associated with various diseases, including age-related eye diseases such as cataract and age-related macular degeneration. However, the role of LTL in the longitudinal development of glaucoma is still unknown. Here we prospectively evaluate the association of LTL with glaucoma incidence and related traits, in the UK Biobank cohort.Methods: The study cohort included 419,603 participants with complete baseline data for glaucoma analyses. Multivariable Cox proportional hazards models were used to evaluate the association between LTL and the risk of glaucoma incidence, and multivariable linear regression was employed to test the association between LTL and glaucoma-related traits.Results: During a 13.58-year follow-up period, 7385 (1.76%) participants developed glaucoma. No association between LTL and incident glaucoma was found in either Model 1 (adjusted for age, sex, ethnicity and the ancestry components; HR = 1.011, 95% CI: 0.990-1.033; P = 0.311), or Model 2 (additionally adjusted for smoking status, alcohol consumption, body mass index, systolic blood pressure, education level, Townsend Deprivation Index, polygenic risk score for glaucoma, and history of diabetes and cardiovascular diseases; HR = 1.010, 95% CI: 0.988-1.032; P = 0.367). Non-significant associations were also observed for glaucoma-related traits, including the retinal nerve fibre layer, ganglion cell-inner plexiform layer, and intraocular pressure with LTL (all P-values > 0.05), but LTL was associated with a slightly increased vertical cup-to-disc ratio (P = 0.009).Conclusions: This study suggested that LTL is not a major biomarker for incident glaucoma in the UK Biobank population. Further studies in different populations are warranted.","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NAION risk with semaglutide: what we know so far. 西马鲁肽的nion风险：我们目前所知道的。

IF 2.8 3区医学

Eye Pub Date : 2025-05-07 DOI: 10.1038/s41433-025-03833-y

Alan Y Hsu, Yu-Hsun Wang, Chun-Ju Lin, Ning-Yi Hsia, Yi-Ching Shao, Chun-Chi Chiang, Huan-Sheng Chen, Yi-Yu Tsai, James Cheng-Chung Wei

引用次数: 0

Endoresection of choroidal melanoma: practical and safety considerations. 脉络膜黑色素瘤的内切术：实用性和安全性考虑。

IF 2.8 3区医学

Eye Pub Date : 2025-05-06 DOI: 10.1038/s41433-025-03827-w

Rodrigo Anguita, Jens Folke Kiilgaard

引用次数: 0

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