Eye最新文献

{"title":"Internal limiting membrane peel size and macular hole surgery outcome: a systematic review and individual participant data study of randomized controlled trials.","authors":"Boon Lin Teh, Yanda Li, Keean Nanji, Mark Phillips, Varun Chaudhary, David H Steel","doi":"10.1038/s41433-025-03666-9","DOIUrl":"10.1038/s41433-025-03666-9","url":null,"abstract":"<p><strong>Background: </strong>There is no consensus regarding the optimal internal limiting membrane (ILM) peel size during vitrectomy for idiopathic full thickness macular holes (iFTMH).</p><p><strong>Methods: </strong>A systematic review was performed to identify randomized controlled trials (RCTs) comparing vitrectomy with ILM peeling of differing sizes in adults with iFTMH. Individual participant data was obtained including relevant baseline variables. The effect of different ILM peel sizes, divided into \"small\" (1-disc diameter [DD] in radius or less) and \"large\" (>1-DD in radius) were analysed on primary hole closure and postoperative visual acuity (VA) at 6 months. A subgroup analysis analysing for the effect of macular hole size on the same outcomes was also performed. Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) was used to assess the certainty of evidence.</p><p><strong>Results: </strong>Five RCTs with 370 eyes were included. Primary closure was achieved in 74.7% in small peel group compared to 84.8% in large peel group (p = 0.016). Multilevel logistic regression showed that a peel radius of >1-DD probably improved hole closure slightly with odds ratio (OR) of 1.20 (95% CI: 1.11-1.31, p < 0.001) and a number needed to treat (NNT) to benefit of 31 (95% CI: 21-53). ILM peel size likely did not affect VA. The mean difference in postoperative VA was a -0.05 logMAR gain (2-3 ETDRS letters) (95% CI: -0.13 to 0.02, p = 0.155) in vision with a large ILM peel radius. The GRADE certainty of evidence was moderate for both outcomes. A significantly higher closure rate was found in the large peel group for iFTMH >400 microns with an OR of 1.24 (95% CI: 1.11-1.38, p < 0.001) and NNT to benefit of 21 (95% CI: 17-50), but not in holes <400 microns (OR 1.05 (95% CI: 0.93-1.18, p = 0.396)).</p><p><strong>Conclusions: </strong>Performing ILM peel of more than 1-DD in radius likely improves closure rates for iFTMH although the effect size is relatively small. The effect is greater in holes >400 microns. ILM peel size probably has no significant effect on postoperative VA.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1406-1413"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereopsis in the Infant Aphakia Treatment Study: outcome at 10½ years.","authors":"E Eugenie Hartmann, Carolyn Drews-Botsch, Lindreth DuBois, Scott R Lambert","doi":"10.1038/s41433-025-03731-3","DOIUrl":"10.1038/s41433-025-03731-3","url":null,"abstract":"<p><p>Parts of material previously presented at Annual Meetings of the Association for Research in Vision and Ophthalmology and the American Association of Pediatric Ophthalmology and Strabismus. Trial Registration: ClinicalTrials.gov Identifier: NCT00212134.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1426-1427"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12044073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noncryopexy versus cryopexy treatment during scleral buckling: a systematic review and meta-analysis.","authors":"Kuan-Ying Chen, Yu-Chen Su, Sheng-Min Hsu","doi":"10.1038/s41433-025-03614-7","DOIUrl":"10.1038/s41433-025-03614-7","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the differences in surgical outcomes between scleral buckling (SB) with noncryopexy and cryopexy methods.</p><p><strong>Methods: </strong>We systematically searched the Embase, Medline, Cochrane Library, and Scopus databases for randomized controlled trials (RCTs) published from their inception until January 1, 2024. A random-effects model was applied, and outcomes are presented as risk ratios (RRs) or standardized mean differences with 95% confidence intervals (CIs). The certainty of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation criteria.</p><p><strong>Results: </strong>We included seven RCTs involving a total of 1103 patients. The meta-analysis revealed comparable retinal reattachment rates between noncryopexy and cryopexy methods (RR: 1.00; 95% CI: 0.96-1.05). Our subgroup analysis revealed similar results between nonretinopexy and laser retinopexy subgroups. Moreover, postoperative visual acuity (VA) and complication rates were comparable between noncryopexy and cryopexy methods (proportion of eyes with postoperative VA of 20/40 or better: RR: 1.24, 95% CI: 0.83-1.85; macular pucker: RR: 1.08, 95% CI: 0.53-2.21; cystoid macular oedema: RR: 1.01, 95% CI: 0.79-1.30; and subretinal pigmentary migration: RR: 0.34, 95% CI: 0.08-1.38). However, the certainty of evidence for these outcomes was low to very low, indicating the need for cautious interpretation of these findings.</p><p><strong>Conclusions: </strong>Similar surgical outcomes were noted between noncryopexy and cryopexy methods in SB, suggesting that both methods are effective in repairing rhegmatogenous retinal detachment. However, future studies on a larger scale and with longer follow-ups may be necessary to detect late redetachment and complications.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":"1292-1300"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12043918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143002354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of orbital lymphoproliferative disorders: a retrospective study of 84 cases.","authors":"Xiawei Wang, Menghui Zhang, Ying Chen, Xinyun Wang, Hongguang Cui","doi":"10.1038/s41433-025-03816-z","DOIUrl":"https://doi.org/10.1038/s41433-025-03816-z","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the variations in clinical presentation, imaging characteristics, and immunohistochemical features between benign and malignant orbital lymphoproliferative disorders (OLPDs).</p><p><strong>Methods: </strong>At the Eye Center of the First Affiliated Hospital, Zhejiang University School of Medicine, a retrospective analysis was performed on the clinical records of all patients diagnosed with OLPDs from 2014 to 2022. This study included a comparative analysis between patients diagnosed with benign and malignant OLPDs.</p><p><strong>Results: </strong>A total of 84 patients were included in this research, with a mean age of 62.24 ± 14.52 years and male-to-female ratio of 43:41. The pathological types comprised benign orbital lymphoproliferative tumours (26/84, 31%, mean age 59.31 ± 10.4 years, male-to-female ratio of 16:10) and malignant orbital lymphomas (58/84, 69%, mean age 63.55 ± 15.93 years, male-to-female ratio of 27:31). The most common symptoms in benign and malignant OLPDs were palpable mass and eyelid swelling. Typically, malignant orbital lymphoma masses exhibited low signal intensity on T1-weighted imaging (T1WI), whereas benign lymphoproliferative tumours commonly demonstrated iso-intensity on T1WI. Notably, the expression of cluster of differentiation 3, 5, 10, 23, 43, and human immunoglobulin light chain lambda demonstrated statistically significant differences between the benign and malignant OLPD groups.</p><p><strong>Conclusion: </strong>Benign and malignant OLPDs exhibit similar clinical presentations and imaging characteristics. Currently, distinguishing between benign and malignant OLPDs still requires pathological biopsy. Research on specialized imaging techniques and specific biomarkers for malignant orbital lymphomas is underway, showing potential for enhancing the accuracy of non-invasive diagnoses for benign and malignant OLPDs.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic utility of artificial intelligence software through non-mydriatic digital retinography in the screening of diabetic retinopathy: an overview of reviews.","authors":"Agustín Ciapponi, Jamile Ballivian, Carolina Gentile, Jhonatan R Mejia, Jessica Ruiz-Baena, Ariel Bardach","doi":"10.1038/s41433-025-03809-y","DOIUrl":"https://doi.org/10.1038/s41433-025-03809-y","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the capability of artificial intelligence (AI) in screening for diabetic retinopathy (DR) utilizing digital retinography captured by non-mydriatic (NM) ≥45° cameras, focusing on diagnosis accuracy, effectiveness, and clinical safety.</p><p><strong>Methods: </strong>We performed an overview of systematic reviews (SRs) up to May 2023 in Medline, Embase, CINAHL, and Web of Science. We used AMSTAR-2 tool to assess the reliability of each SR. We reported meta-analysis estimates or ranges of diagnostic performance figures.</p><p><strong>Results: </strong>Out of 1336 records, ten SRs were selected, most deemed low or critically low quality. Eight primary studies were included in at least five of the ten SRs and 125 in less than five SRs. No SR reported efficacy, effectiveness, or safety outcomes. The sensitivity and specificity for referable DR were 68-100% and 20-100%, respectively, with an AUROC range of 88 to 99%. For detecting DR at any stage, sensitivity was 79-100%, and specificity was 50-100%, with an AUROC range of 93 to 98%.</p><p><strong>Conclusions: </strong>AI demonstrates strong diagnostic potential for DR screening using NM cameras, with adequate sensitivity but variable specificity. While AI is increasingly integrated into routine practice, this overview highlights significant heterogeneity in AI models and the cameras used. Additionally, our study enlightens the low quality of existing systematic reviews and the significant challenge of integrating the rapidly growing volume of emerging evidence in this field. Policymakers should carefully evaluate AI tools in specific contexts, and future research must generate updated high-quality evidence to optimize their application and improve patient outcomes.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of glucagon-like peptide-1 agonists on ocular parameters in idiopathic intracranial hypertension patients: a retrospective study.","authors":"Liron Kravetz, Samuel Leeman, Tamir Regev, Eyal Walter, Anat Horev, Mai Ofri, Tomer Kerman, Muhamad Watted, Karina Buklan, Wasim Hin, Yasmin Elobra, Erez Tsumi","doi":"10.1038/s41433-025-03807-0","DOIUrl":"https://doi.org/10.1038/s41433-025-03807-0","url":null,"abstract":"<p><strong>Background: </strong>Idiopathic intracranial hypertension (IIH) is a neurological condition marked by elevated intracranial pressure (ICP) with no evident secondary cause, primarily affecting obese females of childbearing age. While acetazolamide is the standard medical therapy, weight loss is also considered a first-line treatment. Recently, glucagon-like peptide 1 (GLP-1) agonists have garnered interest for IIH management due to their weight reduction and potential CSF production-decreasing effects. This study evaluates the effect of GLP-1 agonists on ocular parameters of IIH.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted using data from 79 IIH patients who met the modified Dandy criteria and were diagnosed between January 2016 and July 2023. All included patients received acetazolamide, while some received additional therapy with a GLP-1 agonist, either liraglutide or semaglutide. The acetazolamide monotherapy group was compared with the combined therapy group. Data on ocular parameters and BMI changes were collected from the Soroka Medical Center's electronic medical records. Patients with incomplete electronic documentation or with any history of invasive interventions were excluded from the study.</p><p><strong>Results: </strong>When comparing 68 patients on acetazolamide alone to 11 patients on combined therapy with acetazolamide and GLP-1 agonists, no significant differences were found in any of the parameters: papilledema grade, best corrected visual acuity (BCVA), visual field (VF) or OCT RNFL thickness improvements over a 12-month period. Seven of the 11 patients in the combined therapy group completed the full year of follow up data and were included in the secondary outcome analysis, which revealed a trend of BMI reduction and possible acetazolamide dose reduction following GLP-1 initiation.</p><p><strong>Conclusion: </strong>This study suggests that GLP-1 agonists effectively reduce BMI, a major risk factor for IIH. Moreover, our analysis of seven patients from the combined therapy group suggests that GLP-1 agonists allow for a reduction in acetazolamide dosage in the treatment of IIH without changing the clinical outcome.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: An education-based intervention investigating the accuracy of community-based optometrists evaluating limbal anterior chamber depth.","authors":"Anish Jindal, Tess Agnew, Dilani Siriwardena, Eleni Nikita, Winifred Nolan","doi":"10.1038/s41433-025-03810-5","DOIUrl":"https://doi.org/10.1038/s41433-025-03810-5","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Axial length as a predictor of myopic macular degeneration: a meta-analysis and clinical study.","authors":"Tong Mu, Hai-Long He, Xuan-Yu Chen, Yu-Xin Fang, Jie Xu, Zi-Bing Jin","doi":"10.1038/s41433-025-03782-6","DOIUrl":"https://doi.org/10.1038/s41433-025-03782-6","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to investigate the relationship between axial length (AL) and the severity of myopic macular degeneration (MMD).</p><p><strong>Methods: </strong>We conducted a comprehensive search of PubMed, Web of Science, and China National Knowledge Infrastructure (CNKI) databases from their inception until October 1, 2023, to identify population-based or hospital-based studies reporting AL across different grades of MMD. Only studies employing the International Photographic Classification and Grading System for Myopic Maculopathy (META-PM) were included. A meta-analysis was performed to assess the association between AL and MMD severity. To further validate our findings, we analyzed data from 395 eyes of 206 participants at Beijing Tongren Hospital, Capital Medical University.</p><p><strong>Results: </strong>The meta-analysis included 20 high-quality studies from seven countries, with 33822 patients studied. Information, including the study name, year of publication, country, sample size, basic demographic characteristics of the participants, AL of different grades of MMD, best corrected visual acuity (BCVA), and spherical equivalent (SE), was extracted. The meta-analysis revealed a significant overall increase in AL as MMD progressed from category C0 to C4 (P < 0.0001). AL exhibited a consistent increasing trend from categories C0 to C3; however, this trend appeared to level off between categories C3 and C4, with no further increase observed. This trend was confirmed by the distribution of our new dataset. A higher prevalence of MMD was significantly associated with longer AL (per 1 mm increase: OR, 1.90; 95% CI, 1.75-2.07; P < 0.001), older age (per 1-year increase: OR, 1.04; 95% CI, 1.02-1.05; P < 0.001), and female gender (OR, 1.89; 95% CI, 1.24-2.89; P < 0.01). Compared with C0, each 1 mm increase in AL was associated with an increasing likelihood of MMD progression, with ORs of 2.8 for C1, 3.6 for C2, 5.2 for C3, and 5.7 for C4. The increase in OR was more pronounced in later stages (C2-C3 and C3-C4) than in earlier transitions (C0-C1 and C1-C2). Similarly, the ORs for age increased significantly from C3 to C4, and the ORs for female gender increased progressively from C2 to C4.</p><p><strong>Conclusions: </strong>The meta-analysis and new clinical study indicate a clear trend of increasing AL with advancing MMD severity from C0 to C4. However, the relationship between AL and MMD progression from C3 to C4 warrants further investigation. Additionally, older age and female gender are identified as risk factors for MMD progression.</p>","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bitot's spot without hypovitaminosis A.","authors":"Noemi Ruiz Del Rio, Juan Benito Miranda Ruiz","doi":"10.1038/s41433-025-03812-3","DOIUrl":"https://doi.org/10.1038/s41433-025-03812-3","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ophthalmology during conflict: a vitreoretinal surgeon's journey in Gaza.","authors":"Omar Hawwa, Saeed Azizi, Mohammed MSallam, Mohamed Tawfik","doi":"10.1038/s41433-025-03802-5","DOIUrl":"https://doi.org/10.1038/s41433-025-03802-5","url":null,"abstract":"","PeriodicalId":12125,"journal":{"name":"Eye","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}