Causal relationships between depression, anxiety, and myopia: a two-sample Mendelian randomization study.

IF 2.8 3区医学 Q1 OPHTHALMOLOGY

Eye Pub Date : 2025-05-13 DOI:10.1038/s41433-025-03841-y

Shengsong Xu, Xiao Wang, Jinyi Xu, Xianghua Tang, Wenlong Hao, Chuqi Xiang, Xingyu Lei, Mengyi Wang, Xiao Yang

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引用次数: 0

Abstract

Objectives: To investigate the causal relationship between depression, anxiety, and myopia.

Methods: The multivariable Mendelian randomization (MR) design using summary statistics from independent genome-wide association studies (GWAS) was employed. The anxiety and depression, were used as exposures, and myopia was used as the outcome. Genetic variants associated with depression were derived using GWAS summary statistics from the FinnGen consortium database. Genetic variants associated with anxiety were derived from the Psychiatric Genomics consortium. The inverse-variance-weighted method was the main applied analytic tool and was complemented with comprehensive sensitivity analyses.

Results: A total of 21, 10 SNPs were selected as instrumental variables for depression and anxiety, respectively. Based on the IVW analysis, both depression (OR = 1.010, 95% CI = 1.002-1.018, P = 0.016) and anxiety (OR = 1.083, 95%CI = 1.022-1.149, P = 0.008) increased the risk of myopia. After adjusting in the multivariable MR, the IVW and Egger methods indicated that depression (OR = 1.004, 95%CI = 1.000-1.008, P = 0.030) or anxiety (OR = 1.004, 95%CI = 1.001-1.008, P = 0.026) was still associated with elevated risks of myopia.

Conclusions: The current study identified a causal relationship between anxiety, depression, and an increased risk of myopia. These observations suggest that when developing strategies to control myopia, it is also important to focus on the mental health of children. Further detailed research is needed to fully understand this issue.

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抑郁、焦虑和近视之间的因果关系：一项双样本孟德尔随机研究。

目的：探讨抑郁、焦虑与近视的因果关系。方法：采用独立全基因组关联研究（GWAS）汇总统计的多变量孟德尔随机化（MR）设计。焦虑和抑郁被用作暴露，近视被用作结果。使用来自FinnGen联盟数据库的GWAS汇总统计数据得出与抑郁症相关的遗传变异。与焦虑相关的遗传变异来自精神病学基因组学联盟。反方差加权法是主要应用的分析工具，并辅以综合敏感性分析。结果：共有21,10个snp分别被选为抑郁和焦虑的工具变量。IVW分析显示，抑郁（OR = 1.010, 95%CI = 1.002 ~ 1.018, P = 0.016）和焦虑（OR = 1.083, 95%CI = 1.022 ~ 1.149, P = 0.008）均增加了近视的发生风险。经多变量MR调整后，IVW和Egger方法显示，抑郁（OR = 1.004, 95%CI = 1.000-1.008, P = 0.030）或焦虑（OR = 1.004, 95%CI = 1.001-1.008, P = 0.026）仍与近视风险升高相关。结论：目前的研究确定了焦虑、抑郁和近视风险增加之间的因果关系。这些观察结果表明，在制定控制近视的策略时，关注儿童的心理健康也很重要。要充分了解这一问题，还需要进一步的详细研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Eye 医学-眼科学

CiteScore

6.40

自引率

5.10%

发文量

481

审稿时长

3-6 weeks

期刊介绍： Eye seeks to provide the international practising ophthalmologist with high quality articles, of academic rigour, on the latest global clinical and laboratory based research. Its core aim is to advance the science and practice of ophthalmology with the latest clinical- and scientific-based research. Whilst principally aimed at the practising clinician, the journal contains material of interest to a wider readership including optometrists, orthoptists, other health care professionals and research workers in all aspects of the field of visual science worldwide. Eye is the official journal of The Royal College of Ophthalmologists. Eye encourages the submission of original articles covering all aspects of ophthalmology including: external eye disease; oculo-plastic surgery; orbital and lacrimal disease; ocular surface and corneal disorders; paediatric ophthalmology and strabismus; glaucoma; medical and surgical retina; neuro-ophthalmology; cataract and refractive surgery; ocular oncology; ophthalmic pathology; ophthalmic genetics.