Eye science Pub Date : 2014-12-01

Ming Luo, Shengsheng Ma, Na Liang

{"title":"Clinical efficacy of toric orthokeratology in myopic adolescent with moderate to high astigmatism.","authors":"Ming Luo, Shengsheng Ma, Na Liang","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: To observe the efficacy of toric design orthokera- tology (ortho-k) for correcting myopia and astigmatism in myopic adolescents with moderate to high astigmatism.Methods: This was a self-controlled clinical study. Twenty-four subjects (42 eyes) aged 9 to 16 years with myopia of 2.50-6.00 D complicated with rule astigmatism of 1.50-3.50 D were fitted with Lucid Night Toric Ortho-k Lenses (LUCID,KO- REA). The changes in uncorrected visual acuity (UCVA), spherical degree, refraction, axial length (AL), and corneal status were assessed at baseline, 1 night, 1 week, 1 month, 3 months, 6 months, and 1 year after the commencement of ortho-k lens wear.Results: The success rate of the first lens fit was 92.8%. The UCVA after ortho-k wearing was improved significantly compared to the baseline during each visit (all P < 0.01), and became stable 1 month after ortho-k. The manifest myopia was significantly reduced from (-3.41 ± 1.27) D to (-0.41 ± 0.37) D by toric ortho-k and the degree of astigmatism from (-1.81 ± 0.53)D to (-0.41 ± 0.39) D after 1 month of lens wear (P < 0.01). The mean AL was (24.47 ± 0.91) mm at baseline, which did not significantly differ from (24.49 ± 0.87) mm and (24.48 ± 0.94) mm after 6 months and 1 year, respectively, of lens wear (both P > 0.05). Grade 1 corneal staining was observed at 1 week (23.8%), 1 month (21.4%), and 1 year (16.7%) following lens wear, and was improved by lens cleaning, discontinuing lens wear, and moistening the cornea with eye drops. No severe adverse events were reported.Conclusion: The toric ortho-k lens was effective and safe for correction of low to moderate myopia in children with moderate to high astigmatism. The lens also effectively controlled axial length elongation during 1 year of observation. However, the long-term efficacy remains to be elucidated.","PeriodicalId":12096,"journal":{"name":"Eye science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33337359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Avastin on the migration and invasion of pterygium fibroblasts. 阿瓦斯汀对翼状胬肉成纤维细胞迁移和侵袭的影响。

Eye science Pub Date : 2014-12-01

Wei Liu, Xiangyin Sha, Ye Wen, Wenting Zhao, Wei Luo, Zanmei Hua

引用次数: 0

Study of problems arising during perioperative care of postoperative endophthalmitis. 术后眼内炎围手术期护理问题的探讨。

Eye science Pub Date : 2014-12-01

Jingyi Lin, Yue Cai, Jiehui Huang, Ronghua Ye

引用次数: 0

Evaluation of tear malate dehydrogenase 2 in mild dry eye disease. 泪液苹果酸脱氢酶2在轻度干眼病中的评价。

Eye science Pub Date : 2014-12-01

Qing Guo, Houbin Huang, Yuli Pi, Hancheng Zhang

{"title":"Evaluation of tear malate dehydrogenase 2 in mild dry eye disease.","authors":"Qing Guo, Houbin Huang, Yuli Pi, Hancheng Zhang","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: To evaluate the effect of tear malate dehydrogenase 2 on monitoring ocular surface injury in mild dry eye (DE) disease.Methods: A total of 15 DE patients (30 eyes) with mild subjective symptoms but no ocular surface fluorescein staining signs were enrolled in this study (DE group). The control group was 15 healthy age- and sex-matched volunteers (30 eyes). All subjects were asked to fill out a DE symptoms questionnaire and take different tests including tear MDH and MDH2 activities evaluation, tear breakup time (TBUT), Schirmer I, and slit-lamp examination of the ocular surface. We investigated different changes in tear MDH and MDH2 activities in the DE group and control group, discussed the association between tear MDH2 activity and DE symptoms, and the relationship between tear MDH2 activity and diagnostic tests (Schirmer I and TBUT). We also analyzed the changes in tear MDH2 activities after the treatment with artificial tears.Results: Tear MDH activities in the DE group and control group were 288 ± 102 U/L and 259 ± 112 U/L, respectively, and this difference was not statistically significant (P > 0.05). The tear MDH2 activities in DE group were significantly increased compared with control group. Tear MDH2 was significantly and negatively correlated with the Schirmer's value (r = -0.733, P < 0.01) and the TBUT value (r = -0.841, P < 0.01). MDH2 also had a significant positive correlation with soreness symptoms (r = 0.687, P < 0.01). Treatment with artificial tears relieved or eliminated all discomfort symptoms, together with a considerable decrease in MDH2 activities (P < 0.01), but no significant changes in the Schirmer and the TBUT tests were observed.Conclusion: Tear MDH2 activity can indicate ocular surface injury in mild DE patients and may be used to monitor the response to therapy.","PeriodicalId":12096,"journal":{"name":"Eye science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33337358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical cooperation during implantation of a Boston type-I keratoprosthesis. 波士顿i型角膜假体植入术中的手术配合。

Eye science Pub Date : 2014-12-01

Bishan Tian, Sufen Lu, Hairong Zhang, Feipeng Wang, Jiaqi Chen, Jiajie Zhai, Lijin Su

引用次数: 0

Short-term ocular toxicity and eye irritation tests following application of sufentanil in rabbits. 舒芬太尼对家兔的短期眼毒性和眼刺激试验。

Eye science Pub Date : 2014-12-01

Hongbin Chen, Zhenghua Chen, Ying Xu

{"title":"Short-term ocular toxicity and eye irritation tests following application of sufentanil in rabbits.","authors":"Hongbin Chen, Zhenghua Chen, Ying Xu","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: To test the safe clinical application of sufentanil as topical ophthalmic drops by examining treated rabbit eyes for ophthalmic irritation signs or short-time toxic reactions.Methods: Twenty-four rabbits were randomly divided into 8 groups (n = 3): The ocular toxicity at 14 d after eye drop ad- ministration was evaluated in groups 1 to 4, and at 30 d post- administration in groups 5 to 8. Groups 1 and 5 were treated with blank vehicle and served as normal controls. The left eyes of rabbits in groups 2 and 6 were exposed to low-dose sufentanil.(5 μg, 2 drops within 5 min), groups 3 and 7 received moderate-dose sufentanil (7.5 μg, 3 drops within 10 min), and groups 4 and 8 received high-dose sufentanil.(10 μg, 4 drops within 15 min). As self-controls, the right eyes of each rabbit were administered an equivalent amount of sodium chloride (9 g/L) at the same drop intervals. At 14 and 30 d after exposure to sufentanil, ophthalmic irritation signs were evaluated and corneas were stained with fluorescein and observed by slit-lamp microscopy. Corneal endothelial counts were performed and toxic reactions were evaluated.Results: Multiple parameters were compared in the control and experimental groups by visual inspection and slit-lamp examination at 14 and 30 d after sufentanil administration. No evidence of irritation signs (including corneal opacity, conjunctival congestion, or edema), eye secretions, iris abnormalities, or temporal eye closure were noted. Corneal en- dothelial cell counts did not significantly differ between the control and experimental groups. Light microscopy revealed no pathological or morphological injury to the cornea, conjunctiva, iris, ciliary body, retina, or optic nerve in either group. The same observation outcomes were noted at 14 and 30 d after administration.Conclusion: Single ocular administration of sufentanil at a dose of 5-10 μg in rabbits yields no ocular irritation or toxic responses at 14 or 30 d following eye drop delivery.","PeriodicalId":12096,"journal":{"name":"Eye science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33337479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toric intraocular lens vs. peripheral corneal relaxing inci- sions to correct astigmatism in eyes undergoing cataract surgery. 环形人工晶状体与周围角膜松弛切口在白内障手术中矫正散光的比较。

Eye science Pub Date : 2014-12-01

Zhiping Liu, Xiangyin Sha, Xuanwei Liang, Zhonghao Wang, Jingbo Liu, Danping Huang

{"title":"Toric intraocular lens vs. peripheral corneal relaxing inci- sions to correct astigmatism in eyes undergoing cataract surgery.","authors":"Zhiping Liu, Xiangyin Sha, Xuanwei Liang, Zhonghao Wang, Jingbo Liu, Danping Huang","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: To compare toric intraocular lens implantation (Toric-IOL) with peripheral corneal relaxing incisions (PCRIs) for astigmatism correction in patients undergoing cataract surgery.Methods: 54 patients (54 eyes) with more than 0.75 diopter (D) of preexisting corneal astigmatism were classified as group A (0.75-1.50D) or group B (1.75-2.50D). The patients were randomized to undergo Toric-IOL or PCRIs in the steep axis with spherical IOL implantation. LogMAR uncorrected visual acuity (LogMAR UCVA), LogMAR best corrected visual acuity (LogMAR BCVA), error of vector (|EV|), surgery induced refraction correction (|SIRC|), and correction rates (CR) were measured 1 month and 6 months postoperatively.Results: At 6 months postoperatively, all 54 eyes had LogMAR BCVA ≤ 0.2. Patients who underwent PCRIs and Toric-IOL with LogMAR BCVA ≤ 0.1 showed no significant differences in group A (P = 1.00) or in group B (P = 0.59). Group A showed no significant differences in LogMAR UCVA (P = 0.70), |EV| (P = 0.13), |SIRC| (P = 0.71), and CR (P = 0.56) in patients underwent PCRIs and Toric-IOL. However, group B showed significant differences in LogMAR UCVA (P < 0.01), |EV| (P < 0.01)), |SIRC| (P < 0.01), and CR (P < 0.01). The LogMAR UCVA and |EV| between 1 and 6 months showed no significant differences in patients in group A. However, in group B, they are significant differences.Conclusion: The efficacy and stability of Toric-IOL and PCRIs were equal in low astigmatic patients. Toric-IOL achieved an enhanced effect over PCRIs in higher astigmatic patients. PCRIs had the more refractive regression than Toric-IOL in 6 months.","PeriodicalId":12096,"journal":{"name":"Eye science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33337357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of the mydriatic effects of mydrin-P and compound tropicamide in the screening of retinopathy of prematurity. mydrin-P与复方tropicamide在早产儿视网膜病变筛查中的效果比较。

Eye science Pub Date : 2014-12-01

Shuke Luo, Zhonghe Wan, Xiaofang Yin, Zuke Ye, Yan Lu

{"title":"Comparison of the mydriatic effects of mydrin-P and compound tropicamide in the screening of retinopathy of prematurity.","authors":"Shuke Luo, Zhonghe Wan, Xiaofang Yin, Zuke Ye, Yan Lu","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: To observe and compare the effects of pupil dilation between Mydrin-P and compound tropicamide in the screening of retinopathy of prematurity.Methods: The right eyes of premature infants received My- drin-P eye drops as the treatment group, whereas the left eyes were administered with compound tropicamide as the control group. The eye drops were delivered every 5 min for three times. The pupil size was observed and recorded at 10, 15, and 20 min after administering mydriasis.Results: The mean pupil diameter did not significantly differ between the treatment and control groups at 10 (6.24 ± 0.72 mm vs. 6.24 ± 0.68 mm, t = 0.00, P = 1.00), 15 (6.83 ± 0.55 mm vs. 6.78 ± 0.54 mm, t = 1.75, P = 0.083) or 20 min (7.22 ± 0.40 mm vs. 7.15 ± 0.50 mm, t = 1.62, P = 0.109), respectively. How- ever, the mean pupil size at any two time points significantly differed in both groups (all P < 0.001).Conclusion: Both Mydrin-P and compound tropicamide exert similar clinical efficacy in the screening of retinopathy of pre- maturity. The most appropriate time for screening was at 20 min after mydriasis.","PeriodicalId":12096,"journal":{"name":"Eye science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33337361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Image features of retinal astrocytic hamartoma in a patient with tuberous sclerosis complex. 结节性硬化症患者视网膜星形细胞错构瘤的影像特征。

Eye science Pub Date : 2014-12-01

Peng Zhang, Dongjie Sun, Jinting Zhu, Juan Li, Yusheng Wang

{"title":"Image features of retinal astrocytic hamartoma in a patient with tuberous sclerosis complex.","authors":"Peng Zhang, Dongjie Sun, Jinting Zhu, Juan Li, Yusheng Wang","doi":"","DOIUrl":"","url":null,"abstract":"Purpose: To describe the image features of retinal astrocytic hamartoma in a 35-year-old male patient with tuberous sclerosis complex (TSC).Methods: Fundus photography, fundus autofluorescence (FAF), fundus fluorescein angiography (FFA), and spectral domain optical coherence tomography (SD-OCT) were performed for this retinal astrocytic hamartoma.Results: Fundus photography showed that the retinal astrocytic hamartoma presented as a well-circumscribed, mulberry-like lesion consisting of glistening yellowish spherules of calcification. FAF demonstrated dense hyper-autofluorescence spots corresponding to retinal astrocytic hamartoma. FFA revealed leakage from dilated retinal capillaries over the hamartoma. SD-OCT indicated moth-eaten optically empty spaces and hyperreflective dots within the lesion. The lesion surface was fluctuate.Conclusion: FAF is a useful imaging modality for obtaining greater contrast between a retinal astrocytic hamartoma and the surrounding retina due to hyper-autofluorescence of calcification in the lesion. FFA is beneficial for monitoring the abnormal blood vessels in these lesions. SD-OCT is capable of visualization the structural details, such as the uneven surface and inner hyperreflective dots.","PeriodicalId":12096,"journal":{"name":"Eye science","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2014-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33337362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pattern of refractive correction and timing of stage II IOL implantation after congenital cataract extraction. 先天性白内障摘出后屈光矫正模式及二期人工晶状体植入术时机。

Eye science Pub Date : 2014-12-01

Yan Li, Haotian Lin

引用次数: 0

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