Shuke Luo, Zhonghe Wan, Xiaofang Yin, Zuke Ye, Yan Lu
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引用次数: 0
Abstract
Purpose: To observe and compare the effects of pupil dilation between Mydrin-P and compound tropicamide in the screening of retinopathy of prematurity.
Methods: The right eyes of premature infants received My- drin-P eye drops as the treatment group, whereas the left eyes were administered with compound tropicamide as the control group. The eye drops were delivered every 5 min for three times. The pupil size was observed and recorded at 10, 15, and 20 min after administering mydriasis.
Results: The mean pupil diameter did not significantly differ between the treatment and control groups at 10 (6.24 ± 0.72 mm vs. 6.24 ± 0.68 mm, t = 0.00, P = 1.00), 15 (6.83 ± 0.55 mm vs. 6.78 ± 0.54 mm, t = 1.75, P = 0.083) or 20 min (7.22 ± 0.40 mm vs. 7.15 ± 0.50 mm, t = 1.62, P = 0.109), respectively. How- ever, the mean pupil size at any two time points significantly differed in both groups (all P < 0.001).
Conclusion: Both Mydrin-P and compound tropicamide exert similar clinical efficacy in the screening of retinopathy of pre- maturity. The most appropriate time for screening was at 20 min after mydriasis.
目的:观察和比较Mydrin-P与复方托品酰胺瞳孔扩张在早产儿视网膜病变筛查中的作用。方法:以早产儿右眼滴入My- drin-P滴眼液为治疗组,左眼滴入复方托品酰胺为对照组。每5分钟滴眼3次。观察瞳孔大小,并记录于10、15、20分钟后给眼。结果:治疗组和对照组的平均瞳孔直径分别在10(6.24±0.72 mm vs 6.24±0.68 mm, t = 0.00, P = 1.00)、15(6.83±0.55 mm vs 6.78±0.54 mm, t = 1.75, P = 0.083)和20 min(7.22±0.40 mm vs 7.15±0.50 mm, t = 1.62, P = 0.109)时无显著差异。然而,两组在任意两个时间点的平均瞳孔大小有显著差异(均P < 0.001)。结论:Mydrin-P与复方托品酰胺筛查早产儿视网膜病变的临床疗效相近。筛检的最佳时间为虫蛀后20 min。