European Neurology最新文献_第2页

Causal Associations Between Tea Consumption and REM Sleep Behavior Disorder: A Mendelian Randomization Study. 饮茶与快速眼动睡眠行为障碍之间的因果关系：孟德尔随机研究》。

IF 2.4 4区医学

European Neurology Pub Date : 2024-09-09 DOI: 10.1159/000541288

Jinyu Li,Zixuan Zhang,Fujia Li,Yuning Liu,Peixiao Yin,Xi Wang,Shuming Huang,Jie Zu,Shenyang Zhang,Liguo Dong,Chuanying Xu,Tao Zhang,Ran Xu,Chao Sun,Zhi Wang,Yumeng Li,Xueling Zhang,Guiyun Cui,Wei Zhang

{"title":"Causal Associations Between Tea Consumption and REM Sleep Behavior Disorder: A Mendelian Randomization Study.","authors":"Jinyu Li,Zixuan Zhang,Fujia Li,Yuning Liu,Peixiao Yin,Xi Wang,Shuming Huang,Jie Zu,Shenyang Zhang,Liguo Dong,Chuanying Xu,Tao Zhang,Ran Xu,Chao Sun,Zhi Wang,Yumeng Li,Xueling Zhang,Guiyun Cui,Wei Zhang","doi":"10.1159/000541288","DOIUrl":"https://doi.org/10.1159/000541288","url":null,"abstract":"BACKGROUNDPrevious studies have shown that tea consumption may have a protective effect against neurodegenerative diseases. However, the exact causal relationship between tea consumption and the precursor stages of certain neurodegenerative diseases, namely REM sleep behavior disorder (RBD), remains unclear. To evaluate the causal association between tea consumption and RBD, we employed a Mendelian randomization study.METHODSWe identified genetic instrumental variables that are significantly associated with tea consumption through genome-wide association studies (GWAS) in European populations. Bidirectional two-sample Mendelian randomization was utilized to determine the causal relationship between tea consumption and RBD, while sensitivity analyses were further employed to evaluate the robustness of the results. The multivariate Mendelian randomization method was used to assess the influence of relevant confounding factors on the results.RESULTSIn the MR analysis using the inverse variance weighting method, a significant causal relationship between tea consumption and RBD was observed (OR=0.046, 95% CI 0.004-0.563, p=0.016). The consistency of findings across maximum likelihood, MR PRESSO, and multivariate MR after adjusting for potential confounding further supports this causal association. Sensitivity analyses revealed no evidence of heterogeneity or pleiotropy.CONCLUSIONSThe findings of our study demonstrate a robust causal association between tea consumption and RBD, indicating that tea consumption may serve as a protective factor against the development of RBD.","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":"53 1","pages":"1-20"},"PeriodicalIF":2.4,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Examining the Prevalence of Left Atrial Appendage Thrombus in a Cohort of Acute Stroke Patients with an Extended Computed Tomography Angiographic Protocol. 通过扩展 CT 血管造影方案，研究急性中风患者队列中左心房阑尾血栓的发生率。

IF 2.1 4区医学

European Neurology Pub Date : 2024-01-01 Epub Date: 2024-05-16 DOI: 10.1159/000539170

Szabolcs István Antal, Nikoletta Szabó, Róbert Klucsai, Péter Klivényi, Zsigmond Támas Kincses

{"title":"Examining the Prevalence of Left Atrial Appendage Thrombus in a Cohort of Acute Stroke Patients with an Extended Computed Tomography Angiographic Protocol.","authors":"Szabolcs István Antal, Nikoletta Szabó, Róbert Klucsai, Péter Klivényi, Zsigmond Támas Kincses","doi":"10.1159/000539170","DOIUrl":"10.1159/000539170","url":null,"abstract":"Introduction: Current guidelines recommend transthoracic echocardiography (TTE) for routine screening of cardiac emboli; however, the visualization of the left atrial appendage (LAA) where the thrombi are commonly found is poor. Transesophageal echocardiography (TEE) would provide better detectability of LAA thrombus, but it is a time-consuming and semi-invasive method. Extending non-gated carotid computed tomography angiography (CTA) examination to the LAA could reliably detect thrombi and could also aid treatment and secondary prevention of stroke.Methods: We extended the CTA scan range of acute stroke patients 4 cm below the carina to include the left atrium and appendage. During the review, we evaluated LAA thrombi based on contrast relations. We then used gradient boosting to identify the most important predictors of LAA thrombi from a variety of different clinical parameters.Results: We examined 240 acute stroke patients' extended CTA scans. We detected LAA thrombi in eleven cases (4.58%), eight of them had atrial fibrillation. 23.75% of all patients (57 cases) had recently discovered or previously known atrial fibrillation. Windsack morphology was the most commonly associated morphology with filling defects on CTA. According to the gradient-boosting analysis, LAA morphology showed the most predictive value for thrombi.Conclusion: Our extended CTA scans reliably detected LAA thrombi even in cases where TTE did not and showed that 2 patients' LAA thrombus would have been untreated based on electrocardiogram monitoring and TTE. We also showed that the benefits of CTA outweigh the disadvantages arising from the slight amount of excess radiation.","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"105-112"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11332310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Differences in Outcomes after Endovascular Thrombectomy for Patients with Acute Ischemic Stroke. 急性缺血性脑卒中患者血管内血栓切除术后疗效的性别差异。

IF 2.1 4区医学

European Neurology Pub Date : 2024-01-01 Epub Date: 2024-05-24 DOI: 10.1159/000539269

Yimin Chen, Xuehua Zeng, Angela T H Kwan, Mohammad Mofatteh, Thanh N Nguyen, Sijie Zhou, Hongquan Wei, Adam A Dmytriw, Robert W Regenhardt, Zile Yan, Shuiquan Yang, Xiaodong Cai, Mohamad Abdalkader, Xuxing Liao

{"title":"Sex Differences in Outcomes after Endovascular Thrombectomy for Patients with Acute Ischemic Stroke.","authors":"Yimin Chen, Xuehua Zeng, Angela T H Kwan, Mohammad Mofatteh, Thanh N Nguyen, Sijie Zhou, Hongquan Wei, Adam A Dmytriw, Robert W Regenhardt, Zile Yan, Shuiquan Yang, Xiaodong Cai, Mohamad Abdalkader, Xuxing Liao","doi":"10.1159/000539269","DOIUrl":"10.1159/000539269","url":null,"abstract":"Introduction: Endovascular thrombectomy (EVT) is the standard of care for patients with large-vessel occlusion acute ischemic stroke (AIS). There may be differing recanalization effectiveness based on patients' sex, and understanding such variations can improve patient outcomes by adjusting for differences. We aimed to assess the sex differences in outcome after EVT for patients with AIS.Methods: We retrospectively analyzed 250 consecutive AIS patients who underwent EVT from July 2019 to February 2022 across two large comprehensive tertiary care stroke centers in China. Outcomes of male patients were compared to females, where poor outcome was defined as a modified Rankin score (mRS) of 3-6 at 90 days.Results: Male patients had higher rates of symptomatic intracranial hemorrhage (sICH) (12.50% vs. 4.05%, p = 0.042) and higher hospitalization costs (114,541.08 vs. 105,790.27 RMB, p = 0.024). Male patients also had a longer median onset-to-needle time (ONT) (146.00 [104.00, 202.00] versus 120.00 [99.25, 144.75], p = 0.026). However, there were no differences in hospitalization length (p = 0.251), 90-day favorable outcome (p = 0.952), and 90-day mortality (p = 0.931) between the sexes.Conclusion: Female patients had lower hospitalization costs and sICH rates than males after EVT for AIS. Identifying such differences and implementing measures, including adaptations to workflow optimization, would help to reduce the ONT and last known normal-to-puncture time seen in males to improve patient outcomes. Despite such variations, favorable outcomes and mortality are similar in female and male AIS patients.","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"113-121"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum. 勘误。

IF 2.1 4区医学

European Neurology Pub Date : 2024-01-01 Epub Date: 2024-08-09 DOI: 10.1159/000540432

引用次数: 0

Effects and Safety of Monoamine Oxidase-B Inhibitors for Early Parkinson's Disease: A Network Meta-Analysis. 单胺氧化酶-B 抑制剂治疗早期帕金森病的效果和安全性：网络荟萃分析。

IF 2.1 4区医学

European Neurology Pub Date : 2024-01-01 Epub Date: 2024-09-14 DOI: 10.1159/000541315

Yaping Wang, Zhiyun Wang

{"title":"Effects and Safety of Monoamine Oxidase-B Inhibitors for Early Parkinson's Disease: A Network Meta-Analysis.","authors":"Yaping Wang, Zhiyun Wang","doi":"10.1159/000541315","DOIUrl":"10.1159/000541315","url":null,"abstract":"Introduction: The objective of this study was to evaluate the effects and safety of monoamine oxidase-B inhibitors (MAO-B inhibitors) for early Parkinson's disease (PD).Methods: All studies that assessed the efficacy of MAO-B inhibitors in patients with early PD were searched. Publications were screened, and data were extracted according to predefined criteria. Rev Man 5.4 and Stata 14.0 software were used for statistical analysis. Outcomes assessed included change of Unified Parkinson's Disease Rating Scale (UPDRS) total score, UPDRS part II score, UPDRS part III score, and the incidence of adverse events.Results: Thirty trials were identified and included in this meta-analysis. Compared with placebo, rasagiline, selegiline, safinamide, and zonisamide were significantly more effective, with a standardized mean difference (SMD) of -0.41 (95% confidence interval (CI) = -0.64 to -0.18), SMD = -0.38 (95% CI = -0.51 to -0.24), SMD = -0.37 (95% CI = -0.54 to -0.21), and SMD = -0.31 (95% CI = -0.57 to -0.05) on the UPDRS III score change, respectively. The surface under the cumulative ranking results showed that rasagiline ranked first in improving UPDRS II and UPDRS III, respectively. For safety outcomes, safinamide combination with dopaminergic treatment had lower risk of incurring any adverse events (risk ratio = 0.1, 95% CI = 0.01-0.2), and no statistical difference in incidence of adverse events was observed among other MAO-B inhibitor regimes and placebo.Conclusion: Rasagiline, selegiline, safinamide, and zonisamide were effective compared to placebo in the treatment of early PD, but rasagiline was the most effective drug. As for safety, safinamide combination with dopaminergic treatment had lower risk of incurring any adverse events.","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"273-290"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of Thrombectomy in Nonagenarians: A Scoping Review. 血栓切除术在非老年人中的实用性：范围界定综述。

IF 2.1 4区医学

European Neurology Pub Date : 2024-01-01 Epub Date: 2024-06-14 DOI: 10.1159/000539789

Benjamin P Sugar, Nathan E Drasler, Jonathan Lee, Bryce D Beutler, Alastair E Moody, John Jay P Cadavona, Lisa Leung, Burton J Tabaac

{"title":"Utility of Thrombectomy in Nonagenarians: A Scoping Review.","authors":"Benjamin P Sugar, Nathan E Drasler, Jonathan Lee, Bryce D Beutler, Alastair E Moody, John Jay P Cadavona, Lisa Leung, Burton J Tabaac","doi":"10.1159/000539789","DOIUrl":"10.1159/000539789","url":null,"abstract":"Background: Mechanical thrombectomy represents a mainstay of management for acute ischemic stroke in the setting of large vessel occlusion. However, there are no clinical practice guidelines defining the role of thrombectomy at the extremes of age. In this scoping review, we aimed to summarize the existing medical and neurosurgical literature pertaining to mechanical thrombectomy in nonagenarians. The PubMed database was queried using the following terms and relevant citations assessed: \"thrombectomy nonagenarian,\" \"thrombectomy age 90,\" \"stroke nonagenarian,\" and \"ischemic stroke thrombectomy.\" Common measurable outcomes, including mortality, modified Rankin scale (mRS) score, and thrombolysis in cerebral infarction (TICI) scale score, were utilized to compare results.Summary: Thrombectomy was shown to improve functional outcomes in all eight of the studies included in the analysis. Mortality was assessed in only two reported studies, and thrombectomy was shown to provide a mortality benefit in 1 study among patients for whom first-pass reperfusion was achieved. Other outcomes of reported interest included greater early neurologic recovery at discharge and improved functional outcomes at 90 days among nonagenarians who underwent thrombectomy as compared to those who received thrombolytic therapy alone. Nonagenarians with good functional status at baseline were the most likely to have favorable outcomes.Key messages: Mechanical thrombectomy improves outcomes among nonagenarians presenting with acute ischemic stroke due to large vessel occlusion. Further large-scale prospective studies are warranted to optimize patient selection and develop clinical practice guidelines specific to this important patient demographic.","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"122-129"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality of Life in Patients with Excellent 3-Month Clinical Outcome after First-Ever Ischemic Stroke: A Time to Redefine Excellent Outcome? 首次发生缺血性卒中后三个月临床疗效极佳的患者的生活质量：是时候重新定义优秀预后了吗？

IF 2.4 4区医学

European Neurology Pub Date : 2024-01-01 Epub Date: 2024-01-17 DOI: 10.1159/000535685

Daniel Šaňák, Elena Gurková, Lenka Štureková, Šárka Šaňáková, Jana Zapletalová, David Franc, Daniela Bartoníčková

{"title":"Quality of Life in Patients with Excellent 3-Month Clinical Outcome after First-Ever Ischemic Stroke: A Time to Redefine Excellent Outcome?","authors":"Daniel Šaňák, Elena Gurková, Lenka Štureková, Šárka Šaňáková, Jana Zapletalová, David Franc, Daniela Bartoníčková","doi":"10.1159/000535685","DOIUrl":"10.1159/000535685","url":null,"abstract":"Introduction: Ischemic stroke (IS) may have impact on long-term health-related quality of life (HRQoL) even in the patients with good clinical outcome, and tools mostly used for the assessment of outcome may underestimate or not reflect all relevant sequels after IS. We aimed to analyze HRQoL in the patients with excellent outcome after IS.Methods: We analyzed consecutive IS patients enrolled in the prospective FRAILTY study (ClinicalTrials.gov: NCT04839887) with excellent 3-month clinical outcome (score 0-1 in modified Rankin Scale [mRS]). Stroke Impact Scale (SIS) version 3.0 and Hospital Anxiety and Depression Scale (HADS) were used for the HRQoL, anxiety, and depression assessments, and subgroup comparisons were performed according to NIHSS score (0, ≥1), age (50<, ≥50 years), and sex.Results: In total, 158 patients (55.7% men, mean age 60.3 ± 13.4 years) were analyzed, and 72.2% of them had score 0 in mRS. The overall lowest median scores were found in the SIS domain \"emotion,\" \"strength,\" and \"participation.\" Patients with NIHSS ≥1 had lower scores in all SIS domains except \"emotions\" and \"mobility.\" Patients ≥50 years had lower score in \"mobility\" (p = 0.004) and females in domain of \"social participation\" (p = 0.044). No differences were found among all subgroups in HADS anxiety and depression. Age, NIHSS score, and depression were found negative predictors for the physical domains of HRQoL.Discussion/conclusions: Despite excellent 3-month clinical outcome after IS, patients had affected substantially their HRQoL, especially those with NIHSS ≥1. Patients ≥50 years had more affected \"mobility\" and females \"social participation.\"","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"1-10"},"PeriodicalIF":2.4,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139485322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemorrhagic Stroke as Inspiration for Poetry: The Case of Alfred Tennyson, Arthur Henry Hallam, and In Memoriam A.H.H. 出血性中风作为诗歌的灵感:阿尔弗雷德·丁尼生、阿瑟·亨利·哈勒姆和纪念A.H.H.的案例

IF 2.4 4区医学

European Neurology Pub Date : 2024-01-01 Epub Date: 2023-11-21 DOI: 10.1159/000535327

Matheus Pedro

引用次数: 0

Variations in Risk Factors across Different Periods of Stroke and Transient Ischemic Attack Recurrence. 中风和短暂性脑缺血发作复发不同时期风险因素的变化。

IF 2.1 4区医学

European Neurology Pub Date : 2024-01-01 Epub Date: 2024-07-27 DOI: 10.1159/000540571

Sang-Hun Lee, Jin-Man Jung, Jae-Chan Ryu, Moon-Ho Park

{"title":"Variations in Risk Factors across Different Periods of Stroke and Transient Ischemic Attack Recurrence.","authors":"Sang-Hun Lee, Jin-Man Jung, Jae-Chan Ryu, Moon-Ho Park","doi":"10.1159/000540571","DOIUrl":"10.1159/000540571","url":null,"abstract":"Introduction: Accurately discerning periods of heightened risk of stroke or transient ischemic attack (TIA) recurrence and managing modifiable risk factors are essential for minimizing overall recurrence risk. This study identified differences in the timing of stroke or TIA recurrence based on risk factors and patient characteristics to develop strategies for reducing recurrence in clinical practice.Methods: We retrospectively selected patients with ischemic stroke or TIA at the Korea University Ansan Hospital Stroke Center between March 2014 and December 2021 using the prospective institutional database of the Korea University Stroke Registry. We collected demographic, clinical data, and categorized participants by recurrence timing (early within or late after 3 months). Using multinomial logistic regression analysis, we examined variables associated with early and late recurrent stroke or TIAs.Results: Among 3,646 patients, 255 experienced a recurrent stroke or TIA and 3,391 experienced their first stroke or TIA. Multinomial logistic regression analysis revealed significant associations between early recurrent stroke or TIA and diabetes mellitus (odds ratio [OR]: 1.98, 95% confidence interval [CI]: 1.25-3.15), other determined etiologies in the Trial of Org 10172 in the Acute Stroke Treatment classification (OR: 3.00, 95% CI: 1.37-6.61), and white matter changes (OR: 1.97, 95% CI: 1.17-3.33). Late recurrence showed a significant correlation with TIA (OR: 2.95, 95% CI: 1.52-5.71) and cerebral microbleeds (OR: 2.22, 95% CI: 1.32-3.75).Conclusion: Substantial differences in factors contribute to stroke or TIA recurrence based on timing. Managing the risk of recurrence in clinical practice necessitates accurate identification of heightened risk periods and rigorous control of modifiable risk factors.","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"213-222"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11651328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Follicular T Helper and T Helper 17 Cells-Related Molecules on Disease Severity in Patients with Myasthenia Gravis. 滤泡 T 辅助细胞和 T 辅助细胞 17 相关分子对重症肌无力患者病情严重程度的影响

IF 2.1 4区医学

European Neurology Pub Date : 2024-01-01 Epub Date: 2024-08-21 DOI: 10.1159/000540794

Doruk Arslan, Zeynep Ergul-Ulger, Sibel Goksen, Gunes Esendagli, Sevim Erdem-Ozdamar, Ersin Tan, Can Ebru Bekircan-Kurt

{"title":"Effect of Follicular T Helper and T Helper 17 Cells-Related Molecules on Disease Severity in Patients with Myasthenia Gravis.","authors":"Doruk Arslan, Zeynep Ergul-Ulger, Sibel Goksen, Gunes Esendagli, Sevim Erdem-Ozdamar, Ersin Tan, Can Ebru Bekircan-Kurt","doi":"10.1159/000540794","DOIUrl":"10.1159/000540794","url":null,"abstract":"Introduction: Contribution of T helper 1 and 2 cells-related cytokines to pathogenesis of myasthenia gravis (MG) is well known. Recently, the contribution of follicular T helper (Tfh) and T helper 17 cells-related molecules to the pathogenesis has gained importance. In this study, we aimed to evaluate the changes in Tfh- and Th17-related molecules before and after rescue therapy in patients with myasthenic crisis (cMG) and to reveal the molecular differences between stable MG and cMG patients.Methods: Patients with stable generalized MG (gMG) and cMG were classified according to Myasthenia Gravis Foundation of America (MGFA) classification. Serum samples were collected from cMG patients both before and after rescue therapy (plasmapheresis or intravenous immunoglobulin [IVIg]). Serum levels of Tfh- and selected Th17-related molecules (IL-22, IL-17A, CXCL13, sPD-L1, sICOSLG, and sCD40L) were analyzed by commercial ELISA kits.Results: Twelve cMG (6 for IVIg, 6 for plasmapheresis) and 10 gMG patients were included in the study. A decrease in serum sPD-L1 and CXCL13 levels was observed in cMG patients after treatment, regardless of the treatment modality (p < 0.05). In contrast, serum sICOSLG levels decreased only in patients treated with IVIg (p < 0.05) and serum IL-22 levels increased in patients receiving plasmapheresis (p < 0.05). cMG patients had higher serum IL-17A levels compared to stable patients (p < 0.001) and its level was positively correlated with disease severity (r = 0.678, p = 0.001).Conclusion: Our results confirm the contribution of Tfh- and Th17-related cell pathways to MG pathogenesis. Both IVIg and plasmapheresis appear to be effective in reducing Tfh- and Th17-related cytokine/molecule levels in cMG patients. Increased serum IL-17A levels may contribute to disease severity.","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"223-229"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0