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Intensive antihypertensive treatment and cerebral small vessel disease: A systematic review and meta-analysis of randomized clinical trials. 强化降压治疗与脑血管疾病:随机临床试验的系统回顾和荟萃分析
IF 2.4 4区 医学
European Neurology Pub Date : 2025-07-26 DOI: 10.1159/000547434
Ziwei Liao, Liping Cheng, Yining Wang, Yanjuan Yang, Xiaoxian Lv, Ping Gu
{"title":"Intensive antihypertensive treatment and cerebral small vessel disease: A systematic review and meta-analysis of randomized clinical trials.","authors":"Ziwei Liao, Liping Cheng, Yining Wang, Yanjuan Yang, Xiaoxian Lv, Ping Gu","doi":"10.1159/000547434","DOIUrl":"https://doi.org/10.1159/000547434","url":null,"abstract":"<p><p>Background and Objectives Hypertension is a significant risk factor for the development of cerebral small vessel disease (SVD). This study was performed to evaluate the impact of intensive antihypertensive treatment on the progression of imaging markers and cognitive fuction of SVD. Methods Two independent reviewers searched for randomised controlled trials (RCTs) that investigated the associations between intensive antihypertensive treatment and the progression of imaging markers of SVD, including white matter hyperintensities (WMHs), brain atrophy, lacunes, or microbleeds and cognitive function scores. Fixed-effects models were used to pool the data for WMHs, brain atrophy, and severe adverse events, whereas cognitive function scores were synthesised with a random-effects model and were measured as standardised mean differences (SMDs) and odds ratios (ORs). Results A total of 8 RCTs were included in this meta-analysis, involving 2,891 participants with a follow-up period of 24 to 49 months. Compared with standard blood pressure treatment, intensive antihypertensive treatment was observed to be more effective at delaying WMH progression (SMD = -0.33, 95% CI: -0.44, -0.21) but was associated with greater brain volume loss (SMD = 4.06, 95% CI: 1.97 6.15). No increased risk of incident lacunes (odds ratio [OR] = 1.11, 95% CI: 0.57 2.19) or significant association with cognitive function changes (SMD = -0.08, 95% CI: -0.23 0.06) was observed. However, the pooled analysis of cerebral microbleeds was limited by the small number of eligible studies included in this meta-analysis.</p>","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"1-16"},"PeriodicalIF":2.4,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence chatbots and narcolepsy: friend or foe for patient information? 人工智能聊天机器人与嗜睡症:患者信息的是敌是友?
IF 2.1 4区 医学
European Neurology Pub Date : 2025-07-24 DOI: 10.1159/000547034
Francisco Henriques, Christine Costa, Bárbara Oliveiros, Joana Barbosa Melo, Claúdia Santos, Joana Jesus-Ribeiro
{"title":"Artificial intelligence chatbots and narcolepsy: friend or foe for patient information?","authors":"Francisco Henriques, Christine Costa, Bárbara Oliveiros, Joana Barbosa Melo, Claúdia Santos, Joana Jesus-Ribeiro","doi":"10.1159/000547034","DOIUrl":"https://doi.org/10.1159/000547034","url":null,"abstract":"<p><strong>Introduction: </strong>Narcolepsy is a rare sleep disorder with a complex clinical picture, which may affect the daily functioning of patients. Artificial intelligence has emerged as a promising tool in healthcare, potentially offering valuable support to patients. However, its accuracy in specific medical domains remains inadequately assessed. This study aimed to evaluate and compare the accuracy, completeness, and readability of responses from ChatGPT, Gemini, and Perplexity to queries about narcolepsy.</p><p><strong>Methods: </strong>Cross-sectional study. A set of 28 common patient questions was selected and entered into the three chatbots. Responses were independently reviewed by three sleep physicians. Accuracy and completeness were rated on predefined 5-point and 3-point scales, respectively. Readability was evaluated using six validated formulas.</p><p><strong>Results: </strong>All chatbots showed median accuracy ranging from \"more correct than incorrect\" to \"completely correct,\" with no significant performance differences. The topics with the lowest scores were \"Treatment and Prognosis\" for ChatGPT and Perplexity, and \"Diagnosis\" for Gemini. Gemini responses were significantly less complete compared to ChatGPT and Perplexity, with median completeness scores for ChatGPT and Perplexity ranging from \"nearly complete\" to \"complete,\" and for Gemini ranging from \"incomplete\" to \"nearly complete.\" All chatbots' responses required an advanced reading level, with Perplexity showing lower readability in five metrics.</p><p><strong>Conclusion: </strong>Our findings highlight the potential of artificial intelligence chatbots to deliver mostly accurate responses to narcolepsy-related queries. However, these tools have limitations, including text accessibility, as the readability of the responses did not align with the recommended standards for health information. Therefore, their use should be integrated with appropriate guidance from healthcare professionals to avoid potential misunderstandings.</p>","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"1-15"},"PeriodicalIF":2.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Choroid plexus calcifications and biomarkers of systemic inflammation: A population study focused on their potential association. 脉络膜丛钙化和全身性炎症的生物标志物:一项关注其潜在关联的人群研究。
IF 2.1 4区 医学
European Neurology Pub Date : 2025-07-17 DOI: 10.1159/000547491
Oscar H Del Brutto, Robertino M Mera, Denisse A Rumbea, Emilio E Arias, Kleber Arriaga, Pablo R Castillo, Vishal Patel
{"title":"Choroid plexus calcifications and biomarkers of systemic inflammation: A population study focused on their potential association.","authors":"Oscar H Del Brutto, Robertino M Mera, Denisse A Rumbea, Emilio E Arias, Kleber Arriaga, Pablo R Castillo, Vishal Patel","doi":"10.1159/000547491","DOIUrl":"https://doi.org/10.1159/000547491","url":null,"abstract":"<p><strong>Introduction: </strong>While small-scale studies have linked calcifications to functional impairment of the choroid plexus, their association with systemic inflammation remains uncertain. This study investigates the relationship between choroid plexus calcifications (CPC) and the systemic immune-inflammation index (SII), a reliable biomarker of systemic inflammation, in middle-aged and older adults.</p><p><strong>Methods: </strong>A cross-sectional, population study of 814 adults aged ≥40 years quantified CPC volumes using CT and automated segmentation. SII was calculated from blood cell counts. Non-parametric and linear regression models assessed the association between CPC and SII.</p><p><strong>Results: </strong>Participants had a mean age of 54.5±11.6 years (59% women), with mean CPC volume of 651.2±373.3 µL, and mean SII of 446.8±247.2 x 10⁹ L. Non-parametric regression indicated a weak negative association between CPC volume and SII. All models showed non-significant negative coefficients, suggesting CPC may reflect a resolved inflammatory state rather than active dysfunction.</p><p><strong>Conclusions: </strong>Study results challenge prior assumptions linking calcifications to choroid plexus dysfunction and systemic inflammation. Although CPC volume was not associated with SII, further research incorporating advanced imaging and broader biomarkers is needed to clarify the role of CPC in inflammatory processes.</p>","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"1-8"},"PeriodicalIF":2.1,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and Brain MRI Characteristics of Patients with Anti-N-Methyl-d-Aspartate Receptor Encephalitis: A 10-Year Retrospective Study. 抗n -甲基-d-天冬氨酸受体脑炎患者的临床和脑MRI特征:一项10年回顾性研究。
IF 2.1 4区 医学
European Neurology Pub Date : 2025-07-11 DOI: 10.1159/000546521
Yuliang Wang, Qin Zhou, Zhaojun Dai, Yingwei Qiu, Hongyan Zhou, Li Feng, Jing Zhao
{"title":"Clinical and Brain MRI Characteristics of Patients with Anti-N-Methyl-<sc>d</sc>-Aspartate Receptor Encephalitis: A 10-Year Retrospective Study.","authors":"Yuliang Wang, Qin Zhou, Zhaojun Dai, Yingwei Qiu, Hongyan Zhou, Li Feng, Jing Zhao","doi":"10.1159/000546521","DOIUrl":"https://doi.org/10.1159/000546521","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study was to investigate the diagnostic utility of brain Magnetic resonance imaging (MRI) in anti-N-methyl-<sc>d</sc>-aspartate receptor encephalitis (anti-NMDAR encephalitis) and analyze the relationship between clinical and brain MRI characteristics and disease prognosis.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on forty-six (59% female, median age: 24.5 years) clinically identified anti-NMDAR encephalitis patients from December 2012 to April 2022. All the patients underwent multiparametric MRI, with thirteen returning for follow-up. All the relevant clinical information was collected. The initial and follow-up brain MRI was sequentially analyzed for signal abnormalities, involvement of anatomy and structure, and brain/structure atrophy by two experienced neuroradiologists. Additionally, the relationship between clinical and brain MRI features and prognosis was examined.</p><p><strong>Results: </strong>The most common symptom (33/46, 72%) in anti-NMDAR encephalitis was aberrant psychiatric behavior. Five (10%) cases combined with other positive antibodies. Although 91% of patients with mRS >2 before treatment, a statistically significant decrease mRS were observed after treatment (mRS: 3.50 ± 0.94 vs. mRS: 1.91 ± 1.53, p < 0.001). More than half of the patients had abnormal MRI findings. T2-weighted fluid-attenuated inversion recovery (FLAIR) hyperintense lesions that involve the frontal lobe and the limbic system are the characteristic imaging predilection of anti-NMDAR encephalitis. On follow-up MRI, we noticed 5 patients with significant hippocampal atrophy. Further analysis showed that the hippocampal involvement was a significant factor in predicting worse mRS scores both before and after treatment (p < 0.05).</p><p><strong>Conclusion: </strong>T2-FLAIR hyperintense lesions in the frontal lobe and the limbic system are indicative of anti-NMDAR encephalitis. The involvement of the hippocampus is a risk factor for a poor prognosis.</p>","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"1-11"},"PeriodicalIF":2.1,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Farewell Editorial. 告别编辑。
IF 2.1 4区 医学
European Neurology Pub Date : 2025-07-01 DOI: 10.1159/000546545
Julien Bogousslavsky
{"title":"Farewell Editorial.","authors":"Julien Bogousslavsky","doi":"10.1159/000546545","DOIUrl":"https://doi.org/10.1159/000546545","url":null,"abstract":"","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"1-2"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Factors associated with time to change of resuscitation code ("DNR") and time to death after a stroke - palliative aspects from a tertiary center. 与中风后复苏代码改变时间(“DNR”)和死亡时间相关的因素——来自三级中心的姑息治疗方面。
IF 2.1 4区 医学
European Neurology Pub Date : 2025-06-30 DOI: 10.1159/000547188
Melissa Correia, Léon von Fournier, Markus Schettle, Giovanna Brandi, David Blum, Susanne Wegener, Caroline Hertler
{"title":"Factors associated with time to change of resuscitation code (\"DNR\") and time to death after a stroke - palliative aspects from a tertiary center.","authors":"Melissa Correia, Léon von Fournier, Markus Schettle, Giovanna Brandi, David Blum, Susanne Wegener, Caroline Hertler","doi":"10.1159/000547188","DOIUrl":"https://doi.org/10.1159/000547188","url":null,"abstract":"<p><strong>Introduction: </strong>Strokes rank among the most common acute conditions in neurology, leading to substantial increases in morbidity and mortality rates. It is essential to preserve patients' autonomy in decision-making regarding resuscitation measures to prevent unnecessary interventions and safeguard their right to self-determination. This study aims to identify the factors associated with an active decision against post-stroke patient resuscitation.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 139 patients from 2014 to 2021 at the University Hospital Zurich, Switzerland. All patients died within three months after stroke, with a documented active decision against resuscitation within this timespan. We examined sociodemographic and clinical factors including outcome scores associated with the decision to change of code status.</p><p><strong>Results: </strong>Our cohort had a median age of 76.8 years, with 58% men. Median duration from stroke until do-not-resuscitate (DNR) decision was 4 days (range=0-69), and 3 days (range=0-59) from DNR decision until death. In total, 5 (range=0-23) documented discussions were held with each patient's family during disease trajectory. Existing illnesses pre-stroke did not significantly influence these decisions. A total of 22.3% (n = 31) of patients received a consultation from palliative care (PC) specialists and/or palliative treatment, and 9.4% (n=13) were referred to the PC ward.</p><p><strong>Conclusions: </strong>Our findings suggest that decisions against resuscitation primarily result from collaboration between healthcare professionals and families, respecting patients' wishes, and were neither associated with co-morbidities nor severity of stroke. Every fifth patient was seen by a palliative care specialist, supporting the complex decision-making in this non-cancer population.</p>","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"1-14"},"PeriodicalIF":2.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144527056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
14 biomarkers and subsequent disability in patients with stroke recurrence: results from the SPARCL trial. 中风复发患者的14种生物标志物和随后的残疾:来自SPARCL试验的结果
IF 2.1 4区 医学
European Neurology Pub Date : 2025-06-24 DOI: 10.1159/000545149
Elena Meseguer, Peter Ganz, Warren Bao, Larry B Goldstein, Gregory M Preston, Henrik Sillesen, K Michael A Welch, Pierre Amarenco
{"title":"14 biomarkers and subsequent disability in patients with stroke recurrence: results from the SPARCL trial.","authors":"Elena Meseguer, Peter Ganz, Warren Bao, Larry B Goldstein, Gregory M Preston, Henrik Sillesen, K Michael A Welch, Pierre Amarenco","doi":"10.1159/000545149","DOIUrl":"https://doi.org/10.1159/000545149","url":null,"abstract":"<p><strong>Objectives: </strong>In patients enrolled in the SPARCL trial levels of osteopontin, neopterin, N-terminal fragment of pro-B-type natriuretic peptide (NT-proBNP), myeloperoxidase, monocyte chemoattractant protein-1 (MCP-1), resistin, matrix metalloproteinase-9 (MMP-9), adiponectin, high-sensitive C-reactive Protein (hsCRP), lipoprotein-associated phospholipase-A2 (Lp-PLA2), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble CD40-ligand (sCD40L) and HDL-Cholesterol (HDL-c) were measured 1-6 months after the qualifying stroke or TIA . We determined whether any of these biomarkers were associated with disability in case of recurrence.</p><p><strong>Material and methods: </strong>Among 463 recurrent strokes, the associations of these biomarkers with the National Institutes of Health-Stroke Scale (NIHSS), Barthel Index, and modified Rankin Score (mRS) measured after 90-days were assessed. Using adjusted logistic regression analysis, biomarker levels were compared between unfavorable versus favorable outcome (NIHSS>2 versus 0-1; Barthel Index <95 versus 95-100; and mRS 2-6 versus 0-1).</p><p><strong>Results: </strong>Higher baseline levels of osteopontin (OR:1.166; CI95%:1.01-1.347, p=0.0367) and neopterin (OR:1.531; CI95%:1.07-2.188, p=0.0195) predicted poorer outcomes after recurrent stroke. For participants with ischemic stroke, higher levels of neopterin (OR:1.488, CI95%:1.022-2.167, p=0.0384) and NT-proBNP, (OR1.399, CI95%:1.035-1.891, p=0.0289) were predictor of unfavorable mRS. Analyses including stroke and TIA showed that lower HDL-c levels were associated with an unfavorable mRS (OR:0.564, CI 95% 0.328-0.971, p=0.0387).</p><p><strong>Conclusions: </strong>Higher levels of osteopontin, neopterin and NT-ProBNP and lower levels of HDL-c after stroke were independently associated with greater disability in case of recurrent stroke.</p>","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"1-17"},"PeriodicalIF":2.1,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Manifestations of Tuberous Sclerosis: A Retrospective Analysis of 20 Cases. 结节性硬化症20例临床分析
IF 2.1 4区 医学
European Neurology Pub Date : 2025-06-10 DOI: 10.1159/000546608
Xu Zhang, Cong Xie, Zhihua Si, Ju Liu, Aihua Wang, Meng Kong, Jinzhi Liu, Zhangyong Xia
{"title":"Clinical Manifestations of Tuberous Sclerosis: A Retrospective Analysis of 20 Cases.","authors":"Xu Zhang, Cong Xie, Zhihua Si, Ju Liu, Aihua Wang, Meng Kong, Jinzhi Liu, Zhangyong Xia","doi":"10.1159/000546608","DOIUrl":"10.1159/000546608","url":null,"abstract":"<p><strong>Introduction: </strong>Tuberous sclerosis (TSC) is an autosomal dominant genetic disorder with a wide range of clinical manifestations. This study aimed to retrospectively analyze the clinical records of TSC patients, focusing on the first onset times and age ranges for various symptoms.</p><p><strong>Methods: </strong>The clinical data of TSC patients were analyzed retrospectively, including general information, clinical manifestations, and treatment plans, with particular attention to the first onset times and age ranges for different symptoms.</p><p><strong>Results: </strong>The study found that 15 patients presented with different types of skin lesions, 13 patients, including 6 with intellectual disabilities, experienced epileptic seizures. Additionally, 14 patients had kidney damage, 6 showed varying degrees of cardiac involvement, and 8 exhibited lung lesions.</p><p><strong>Conclusion: </strong>By integrating the clinical features and imaging characteristics of TSC, multiple manifestations of the disease were identified, providing further clinical evidence for its recognition. This is beneficial for early monitoring and effective disease prevention and improvement.</p>","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"1-10"},"PeriodicalIF":2.1,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Small Fiber Neuropathy in Long COVID: A Cohort Study with Multimodal Assessment and Follow-Up. 长冠状病毒小纤维神经病:一项多模式评估和随访的队列研究。
IF 2.4 4区 医学
European Neurology Pub Date : 2025-06-03 DOI: 10.1159/000546015
Natalia Drobinska, Mayssam Nehme, Fréderic Assal, Emmanuel Laffitte, Idris Guessous, Agustina M Lascano
{"title":"Small Fiber Neuropathy in Long COVID: A Cohort Study with Multimodal Assessment and Follow-Up.","authors":"Natalia Drobinska, Mayssam Nehme, Fréderic Assal, Emmanuel Laffitte, Idris Guessous, Agustina M Lascano","doi":"10.1159/000546015","DOIUrl":"10.1159/000546015","url":null,"abstract":"<p><strong>Introduction: </strong>Given the increasing number of patients suffering from pain associated with dysautonomic symptoms following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, we aimed to estimate the occurrence of small fiber neuropathy (SFN) in a cohort of long coronavirus disease 19 (COVID-19) patients reporting postinfectious neuropathic pain.</p><p><strong>Methods: </strong>The study cohort included 18 patients suffering from neuropathic pain (neuropathic pain score DN4 ≥4) appearing after or during SARS-CoV-2 infection and lasting ≥90 days; presenting normal nerve conduction studies excluding large fiber damage. Patients underwent multimodal SFN evaluation by skin biopsy, quantitative sensory testing (QST), laser evoked potential (LEP) recording and electrochemical skin conductance (ESC; Sudoscan).</p><p><strong>Results: </strong>Out of 18 patients, 17 were analyzed. Participants' ages averaged 44 ± 9 years, with 94% females. Fourteen (82%) had abnormal skin biopsy results. Notably, 12/17 (70%) patients presented with autonomic complaints, all of whom had abnormal skin biopsy results. At 6-month follow-up, 10/17 patients reported a subjective improvement in pain and/or dysautonomia with or without symptomatic pharmacological or non-pharmacological treatment. In our cohort, QST showed the highest sensibility (79%) and specificity (67%), followed by LEP (sensibility 71%, specificity 67%). ESC showed poor reliability in the screening of SFN with a sensibility of 7% and specificity of 50%.</p><p><strong>Conclusion: </strong>The results of our study suggest that SFN may develop during or shortly after SARS-CoV-2 infection, provoking disabling sensory and dysautonomic symptoms that tend to persist for more than 6 months. Furthermore, our findings imply that noninvasive exams are a useful complement to biopsy in the diagnostic process of SFN.</p>","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"1-12"},"PeriodicalIF":2.4,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Charcot's Son's Shift from Medicine to Maritime: "Pourquoi pas?" Charcot的儿子从医学转向海事:“Pourquoi pas?””。
IF 2.1 4区 医学
European Neurology Pub Date : 2025-04-29 DOI: 10.1159/000546117
Emmanuel Drouin, Serge Waserszttum
{"title":"Charcot's Son's Shift from Medicine to Maritime: \"Pourquoi pas?\"","authors":"Emmanuel Drouin, Serge Waserszttum","doi":"10.1159/000546117","DOIUrl":"10.1159/000546117","url":null,"abstract":"","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"1-4"},"PeriodicalIF":2.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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