European Neurology最新文献

{"title":"Charcot's Son's Shift from Medicine to Maritime: <italic>\"Pourquoi pas</italic>?<italic>\"</italic>.","authors":"Emmanuel Drouin, Serge Waserszttum, Emmanuel Drouin","doi":"10.1159/000546117","DOIUrl":"10.1159/000546117","url":null,"abstract":"","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"97-100"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in Markers of Cerebral Small Vessel Disease in Patients with Lobar Intracerebral Hemorrhage.","authors":"Diego Incontri, Sarah Marchina, Mitchell Wilson, Jia-Yi Wang, Merryjean Losso, Alexander Andreev, David Lin, Elizabeth C Heistand, Filipa Carvalho, Juliette Marchal, Anusha Nallaparaju, Vasileios Lioutas, Magdy H Selim","doi":"10.1159/000542983","DOIUrl":"10.1159/000542983","url":null,"abstract":"<p><strong>Introduction: </strong>Cerebral small vessel disease (CSVD) is a major cause of primary lobar intracerebral hemorrhage (ICH) due to cerebral amyloid angiopathy (CAA) or hypertensive arteriopathy (HA). Sex differences in CSVD imaging markers and prevalence of CAA vs HA in lobar ICH remain unexplored.</p><p><strong>Methods: </strong>We performed a retrospective analysis of patients with primary lobar ICH who underwent MRI during hospitalization. We collected demographic, clinical, and outcome data. We reviewed MRIs for CSVD markers and calculated composite CSVD burden score (cCSVDbs). We assigned possible/probable CAA using Boston criteria 2.0. We grouped patients based on their sex and examined associations between sex and CSVD markers, cCSVDbs, or CAA. Kaplan Meier survival analysis was used to determine ICH-onset age among patients with first-ever symptomatic lobar ICH.</p><p><strong>Results: </strong>214 patients were included (102 [47.66%] women). Men were more likely to be current alcohol abusers (25.69% vs. 9.09%, p = 0.002), current smokers (24.30% vs. 12.12%, p = 0.024) and have coronary artery disease (26.79% vs. 15.69%, p = 0.048), and hyperglycemia on admission (142.79 ± 59.59 vs. 126.58 ± 37.29, p = 0.019). Women were older (74.91 ± 11.69 vs. 69.28 ± 14.53 years, p = 0.002), and more likely to have possible/probable CAA in univariate (97.06% vs. 88.39%; OR: 4.33, 95% CI: 1.19-15.67; p = 0.025) but not multivariate analysis. We found no significant differences in MRI markers of CSVD, cCSVDbs, or CAA. Among patients who presented with their first-ever primary symptomatic lobar ICH (n = 187), men were younger than women (73 vs 77 years, p = 0.001).</p><p><strong>Conclusions: </strong>In our cohort of patients with primary lobar ICH, we found no significant difference in clinical and imaging characteristics between sexes. However, men were more likely to have a younger lobar ICH-onset age compared to women.</p>","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"11-17"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Epidemiology of Huntington's Disease in Iceland.","authors":"Saga Briem, Vigdis Stefansdottir, Jon Johannes Jónsson, Olafur Sveinsson, Olafur Sveinsson","doi":"10.1159/000546150","DOIUrl":"10.1159/000546150","url":null,"abstract":"<p><p><p>Introduction: Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by involuntary movements, psychiatric symptoms and cognitive decline. Its prevalence is highest in individuals of European descent. However, a previous study in 2007 in Iceland showed an unusually low incidence and prevalence. The aim of this study was to investigate the incidence and prevalence of HD in Iceland between 2008 and 2022 as well as age, sex, symptoms, number of cytidine-adenosine-guanosine (CAG) repeats, treatment, and prognosis.</p><p><strong>Methods: </strong>A retrospective epidemiological study was conducted with clinical information obtained from medical records of individuals diagnosed with HD 2008-2022. Information was also obtained from the Department of Genetics at University Hospital of Iceland and neurologists managing HD patients.</p><p><strong>Results: </strong>Among the 22 diagnosed individuals (11 men) identified, the point prevalence on December 31, 2022, was 4.38 per 100,000 inhabitants, with an average annual incidence rate of 0.314 per 100,000 person-years. The average age at symptom onset was 46.3 years. A total of 21 out of 22 individuals had confirmed HD through genetic testing, with an average CAG repeat length of 42.3 (range 40-45). Five individuals died during the study period, with the most common cause of death being aspiration pneumonia. The average age at death was 70.4 years.</p><p><strong>Conclusion: </strong>The prevalence and incidence of HD in Iceland have increased compared to the 2007 study but remain lower than in other European populations. Results showed a lower number of CAG repeats in the Icelandic HD population, potentially explaining the higher age at symptom onset and death compared to global averages. </p>.</p>","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"64-70"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12162110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship between Pineal Gland and Choroid Plexus Calcifications: Potential Link for an Intracranial Calcification Phenotype?","authors":"Oscar H Del Brutto, Robertino M Mera, Denisse A Rumbea, Emilio E Arias, Pablo R Castillo, Vishal Patel","doi":"10.1159/000544944","DOIUrl":"10.1159/000544944","url":null,"abstract":"<p><strong>Introduction: </strong>Little is known about the association between the most common brain structures presenting with calcium deposits, the pineal gland and the choroid plexus. This study aimed to assess whether the extent of pineal gland calcifications (PGCs) and choroid plexus calcifications (CPCs) is independent or correlated to each other.</p><p><strong>Methods: </strong>The study included 1,009 individuals aged ≥40 years enrolled in a population-based cohort who received a head CT. Images were converted to the Neuroimaging Informatics Technology Initiative format, and whole brain segmentation was performed using SynthSeg. Voxels within the pineal gland region and the ventricular cavities with attenuation >50 HU were considered to contain a calcified component. Total voxel volumes within both regions were calculated for each participant. Linear regression models were fitted to assess the association between PGC and CPC volumes. Non-parametric locally weighted scatterplot smoothing regression was used to evaluate the relationship between these variables.</p><p><strong>Results: </strong>PGC were associated with CPC (β: 0.018; 95% CI: 0.009-0.027), after adjusting for demographics. The Pearson's correlation coefficient for this association was 0.1636 (p < 0.001), while the Spearman's pairwise rank correlation coefficient was 0.1647 (p < 0.001).</p><p><strong>Conclusions: </strong>PGC and CPC are significantly correlated, suggesting the existence of an intrinsic predisposition to facilitate calcium deposits in brain tissues.</p>","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"28-31"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Brain Functional Connectivity in Patients with Delayed Encephalopathy after Carbon Monoxide Poisoning Based on Functional Near-Infrared Spectroscopy Technology.","authors":"Xin Yang, Lan Zeng, Jinyao Li, Zhiqiang Huang, Weiwei He, Xiaoming Wang, Weiwei He","doi":"10.1159/000545272","DOIUrl":"10.1159/000545272","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to observe the brain network characteristics of delayed encephalopathy after carbon monoxide poisoning (DEACMP) using functional near-infrared spectroscopy (fNIRS) technology.</p><p><strong>Methods: </strong>Fifteen patients with carbon monoxide poisoning (DEACMP group) hospitalized in the Department of Neurology, Affiliated Hospital of North Sichuan Medical College, from November 2023 to March 2024 were selected. Fifteen healthy volunteers (the control group) were also recruited. Six-minute resting-state fNIRS data were collected from all subjects. Five cognitive-related key brain regions were selected as regions of interest (ROI): parietal cortex (PC), premotor cortex (PMC), frontopolar cortex (FPC), orbitofrontal cortex (OFC), and dorsolateral prefrontal cortex (DLPFC). NirSpark software was used to analyze the differences in whole-brain functional connectivity strength and functional connectivity strength within and between ROIs between the two groups.</p><p><strong>Results: </strong>The functional connectivity strength of the left PMC, right PMC, and left FPC, etc. In the DEACMP group, it was significantly lower than that in the control group (p < 0.05, FDR corrected). Compared with the control group, the brain network of DEACMP patients showed heterogeneity from left PC to right PC; left PC∼left PMC; left PC∼right PMC; left PC∼left DLPFC, etc. The functional connectivity strength between the left PC and the right DLPFC area has significantly decreased. All these differences were statistically significant (p < 0.05, FDR adjusted).</p><p><strong>Conclusion: </strong>DEACMP exhibits abnormal functional connectivity in both whole-brain and cognitive-related key brain regions. This aberrant connectivity may represent the underlying neural network mechanisms responsible for the cognitive dysfunction observed in DEACMP.</p>","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"44-51"},"PeriodicalIF":2.4,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Evolution in the Times of the Pandemic and Multimedia.","authors":"Elisabete Castelon Konkiewitz,Edward B Ziff","doi":"10.1159/000541361","DOIUrl":"https://doi.org/10.1159/000541361","url":null,"abstract":"BACKGROUNDIn this paper we argue that recent unprecedented social changes arising from social media and the internet represent powerful behavioral and environmental forces that are driving human evolutionary adaptive responses in a way that might reshape our brain and the way it perceives reality and interacts with it. These forces include decreases in physical activity, decreases in exposure to light and face-to-face social interactions, as well as diminished predictability in biological rhythms (i. e. the sleep cycle is no longer dictated by natural light exposure and season).SUMMARYWe discuss the roles of stress and of creativity and adaptability in Homo sapiens evolution and propose mechanisms for human adaptation to the new forces including epigenetic mechanisms, gene culture coevolution and novel mechanisms of evolution of the nervous system.KEY MESSAGESWe present the provocative idea that evolution under the strong selective pressures of today's society will ultimately enable Homo sapiens to thrive despite social, physical, circadian and cultural deprivation and possible neurological disease, and thus withstand the loss of factors that contribute to Homo sapiens survival of today. The new Homo sapiens would flourish under a lifestyle in which the current form would feel undervalued and replaceable.","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":"35 1","pages":"1-18"},"PeriodicalIF":2.4,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Associations Between Tea Consumption and REM Sleep Behavior Disorder: A Mendelian Randomization Study.","authors":"Jinyu Li,Zixuan Zhang,Fujia Li,Yuning Liu,Peixiao Yin,Xi Wang,Shuming Huang,Jie Zu,Shenyang Zhang,Liguo Dong,Chuanying Xu,Tao Zhang,Ran Xu,Chao Sun,Zhi Wang,Yumeng Li,Xueling Zhang,Guiyun Cui,Wei Zhang","doi":"10.1159/000541288","DOIUrl":"https://doi.org/10.1159/000541288","url":null,"abstract":"BACKGROUNDPrevious studies have shown that tea consumption may have a protective effect against neurodegenerative diseases. However, the exact causal relationship between tea consumption and the precursor stages of certain neurodegenerative diseases, namely REM sleep behavior disorder (RBD), remains unclear. To evaluate the causal association between tea consumption and RBD, we employed a Mendelian randomization study.METHODSWe identified genetic instrumental variables that are significantly associated with tea consumption through genome-wide association studies (GWAS) in European populations. Bidirectional two-sample Mendelian randomization was utilized to determine the causal relationship between tea consumption and RBD, while sensitivity analyses were further employed to evaluate the robustness of the results. The multivariate Mendelian randomization method was used to assess the influence of relevant confounding factors on the results.RESULTSIn the MR analysis using the inverse variance weighting method, a significant causal relationship between tea consumption and RBD was observed (OR=0.046, 95% CI 0.004-0.563, p=0.016). The consistency of findings across maximum likelihood, MR PRESSO, and multivariate MR after adjusting for potential confounding further supports this causal association. Sensitivity analyses revealed no evidence of heterogeneity or pleiotropy.CONCLUSIONSThe findings of our study demonstrate a robust causal association between tea consumption and RBD, indicating that tea consumption may serve as a protective factor against the development of RBD.","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":"53 1","pages":"1-20"},"PeriodicalIF":2.4,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142184756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the Prevalence of Left Atrial Appendage Thrombus in a Cohort of Acute Stroke Patients with an Extended Computed Tomography Angiographic Protocol.","authors":"Szabolcs István Antal, Nikoletta Szabó, Róbert Klucsai, Péter Klivényi, Zsigmond Támas Kincses","doi":"10.1159/000539170","DOIUrl":"10.1159/000539170","url":null,"abstract":"<p><strong>Introduction: </strong>Current guidelines recommend transthoracic echocardiography (TTE) for routine screening of cardiac emboli; however, the visualization of the left atrial appendage (LAA) where the thrombi are commonly found is poor. Transesophageal echocardiography (TEE) would provide better detectability of LAA thrombus, but it is a time-consuming and semi-invasive method. Extending non-gated carotid computed tomography angiography (CTA) examination to the LAA could reliably detect thrombi and could also aid treatment and secondary prevention of stroke.</p><p><strong>Methods: </strong>We extended the CTA scan range of acute stroke patients 4 cm below the carina to include the left atrium and appendage. During the review, we evaluated LAA thrombi based on contrast relations. We then used gradient boosting to identify the most important predictors of LAA thrombi from a variety of different clinical parameters.</p><p><strong>Results: </strong>We examined 240 acute stroke patients' extended CTA scans. We detected LAA thrombi in eleven cases (4.58%), eight of them had atrial fibrillation. 23.75% of all patients (57 cases) had recently discovered or previously known atrial fibrillation. Windsack morphology was the most commonly associated morphology with filling defects on CTA. According to the gradient-boosting analysis, LAA morphology showed the most predictive value for thrombi.</p><p><strong>Conclusion: </strong>Our extended CTA scans reliably detected LAA thrombi even in cases where TTE did not and showed that 2 patients' LAA thrombus would have been untreated based on electrocardiogram monitoring and TTE. We also showed that the benefits of CTA outweigh the disadvantages arising from the slight amount of excess radiation.</p>","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"105-112"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11332310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140944313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex Differences in Outcomes after Endovascular Thrombectomy for Patients with Acute Ischemic Stroke.","authors":"Yimin Chen, Xuehua Zeng, Angela T H Kwan, Mohammad Mofatteh, Thanh N Nguyen, Sijie Zhou, Hongquan Wei, Adam A Dmytriw, Robert W Regenhardt, Zile Yan, Shuiquan Yang, Xiaodong Cai, Mohamad Abdalkader, Xuxing Liao","doi":"10.1159/000539269","DOIUrl":"10.1159/000539269","url":null,"abstract":"<p><strong>Introduction: </strong>Endovascular thrombectomy (EVT) is the standard of care for patients with large-vessel occlusion acute ischemic stroke (AIS). There may be differing recanalization effectiveness based on patients' sex, and understanding such variations can improve patient outcomes by adjusting for differences. We aimed to assess the sex differences in outcome after EVT for patients with AIS.</p><p><strong>Methods: </strong>We retrospectively analyzed 250 consecutive AIS patients who underwent EVT from July 2019 to February 2022 across two large comprehensive tertiary care stroke centers in China. Outcomes of male patients were compared to females, where poor outcome was defined as a modified Rankin score (mRS) of 3-6 at 90 days.</p><p><strong>Results: </strong>Male patients had higher rates of symptomatic intracranial hemorrhage (sICH) (12.50% vs. 4.05%, p = 0.042) and higher hospitalization costs (114,541.08 vs. 105,790.27 RMB, p = 0.024). Male patients also had a longer median onset-to-needle time (ONT) (146.00 [104.00, 202.00] versus 120.00 [99.25, 144.75], p = 0.026). However, there were no differences in hospitalization length (p = 0.251), 90-day favorable outcome (p = 0.952), and 90-day mortality (p = 0.931) between the sexes.</p><p><strong>Conclusion: </strong>Female patients had lower hospitalization costs and sICH rates than males after EVT for AIS. Identifying such differences and implementing measures, including adaptations to workflow optimization, would help to reduce the ONT and last known normal-to-puncture time seen in males to improve patient outcomes. Despite such variations, favorable outcomes and mortality are similar in female and male AIS patients.</p>","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"113-121"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum.","authors":"","doi":"10.1159/000540432","DOIUrl":"10.1159/000540432","url":null,"abstract":"","PeriodicalId":12065,"journal":{"name":"European Neurology","volume":" ","pages":"211"},"PeriodicalIF":2.1,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}