European journal of preventive cardiology最新文献

{"title":"Circulating ketone bodies and risk of incident atrial fibrillation: insights from the MESA and UK Biobank cohorts.","authors":"Vardhmaan Jain, Parag Anilkumar Chevli, Parveen K Garg, James Thomas McParland, Jorge Kizer, Kenneth Mukamal, Christopher L Schaich, Rishi Rikhi, Margery Connelly, Ambarish Pandey, Sadiya Khan, Susan R Heckbert, Michael D Shapiro","doi":"10.1093/eurjpc/zwaf543","DOIUrl":"10.1093/eurjpc/zwaf543","url":null,"abstract":"<p><strong>Aims: </strong>Circulating ketone bodies (KB) are an important source of metabolic fuel for the myocardium under physiological and pathological conditions. Prior studies have linked KB levels with adverse cardiovascular outcomes. However, their relationship with atrial fibrillation (AF) risk remains unknown. The objective is to evaluate the association of KB levels with the risk of incident AF.</p><p><strong>Methods and results: </strong>This prospective, multicentre cohort study recruited patients without baseline AF from the Multi-Ethnic Study of Atherosclerosis (MESA) and the UK Biobank (UKB), respectively. Total KB levels were measured by nuclear magnetic resonance spectroscopy in both studies. The associations between total and individual KB and incident AF were evaluated using multivariable-adjusted Cox proportional hazard models. Prespecified interaction analyses were performed for smoking status, history of diabetes mellitus, history of hypertension, body mass index, and self-reported race/ethnicity (to represent a social construct). A total of 6783 participants [mean (standard deviation, SD) age 62 (10) years, 52% women, 38% White, 27.5% Black, 21.8% Hispanic, and 11.6% Chinese American] from MESA and 116 480 participants [mean (SD) age 56.5 (8) years, 54% women, 94% White] from the UKB were included. Over a median follow-up of 16.5 (10.3-17.4) years in MESA and 13.6 (12.8-14.4) years in the UKB, higher levels of total KB were associated with a higher risk of incident AF. In MESA, each doubling of baseline total KB levels was associated with a 1.08-fold increased hazard of incident AF on follow-up [95% confidence interval (CI): 1.00-1.16] after adjustment for confounding factors. Consistent results were obtained in a subgroup analysis stratified by different types of KB (β-hydroxybutyrate, acetoacetate, and acetone). There was a significant interaction with current smoking, such that per doubling of total KB levels was associated with a 1.32-fold increased hazard for incident AF in current smokers (95% CI: 1.08-1.61), but this association was not seen among former/never smokers [hazard ratio (95% CI): 1.05 (0.95-1.13)]. These results were replicated in the UKB.</p><p><strong>Conclusion: </strong>Higher concentrations of KB are associated with an increased risk of AF in predominantly healthy, community-based cohorts, acknowledging that many participants also had comorbidities such as hypertension and diabetes, particularly among smokers. Ketone bodies could serve as a potential biomarker for identifying populations at risk for AF.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bleeding in Atrial Fibrillation: Unavoidable Risk or Modifiable Target?","authors":"Jacqueline Bosch, Carmen Ka Man Cheung, John Eikelboom","doi":"10.1093/eurjpc/zwaf595","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf595","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythrocyte odd-chain fatty acids and the risk of cardiometabolic diseases: a prospective study and updated meta-analysis.","authors":"Liang Sun, Xinming Xu, Huaidong Du, Ling Lu, Fumiaki Imamura, Qishan Yang, Yiping Chen, Yan Chen, Pei Pei, Huiyong Yin, Ling Yang, Geng Zong, Canqing Yu, Qianqian Chu, Jun Lv, Puchen Zhou, Dianjianyi Sun, Junshi Chen, Xiang Gao, Liming Li, Zhengming Chen, Xu Lin","doi":"10.1093/eurjpc/zwaf601","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf601","url":null,"abstract":"<p><strong>Aim: </strong>To determine dietary sources of odd-chain fatty acids (OCFAs) in Asians and their associations with cardiometabolic diseases (CMDs) and to compare these associations with other populations.</p><p><strong>Methods: </strong>Erythrocyte fatty acids were profiled in 8,185 subjects (38% men, mean age 58.1 years) participating in the 2nd resurvey of the China Kadoorie Biobank (CKB) in 2013-14 using gas chromatography. Correlations of pentadecanoic (15:0) and heptadecanoic (17:0) acids with dietary factors, assessed via food frequency questionnaires, were examined by Spearman correlations. During about 5-year follow-up, 950 incident CMD were recorded, including 387 ischemic heart disease (IHD), 127 diabetes, and 459 stroke. Cox regression yielded adjusted hazard ratios (HRs) for CMDs associated with levels of 15:0. These results were further meta-analyzed with 33 additional prospective studies, involving 112,193 participants.</p><p><strong>Results: </strong>OCFAs were significantly correlated with intakes of dairy products, wheat and coarse grains, and fish/seafood in the CKB. Both 15:0 and 17:0 were inversely associated with incident IHD, with adjusted HRs of 0.72 (95% CI 0.59-0.89) and 0.69 (0.56-0.86) for top vs. bottom tertile, respectively. Levels of 17:0 were also inversely associated with incident diabetes (0.41 [0.27-0.62]) and total CMDs (0.85 [0.74-0.97]). In the updated meta-analysis, both 15:0 and 17:0 levels showed inverse associations with diabetes, with pooled relative risks of 0.74 (0.68-0.80) and 0.65 (0.61-0.71) per 10th-90th percentile range, respectively. 17:0 was also inversely associated with incident IHD (0.87 [0.77-0.97]).</p><p><strong>Conclusions: </strong>Our findings supported favorable associations between OCFAs and CMDs among populations with varied dietary sources and intake levels, which merits future intervention studies.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Reply: Consideration of Possible Involvement of Oxidation of Lp(a) in the Association Between Lp(a) and Atrial Fibrillation.","authors":"Kamal Awad, Chadi Ayoub, Reza Arsanjani","doi":"10.1093/eurjpc/zwaf590","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf590","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise, Novelty and Ageing.","authors":"Ana Abreu","doi":"10.1093/eurjpc/zwaf459","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf459","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145129945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feeding vascular health: role of nutrition in peripheral artery disease prevention and management.","authors":"Thomas Butler, Christopher P Twine, Ana Rodriguez-Mateos, Christian Heiss","doi":"10.1093/eurjpc/zwaf611","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf611","url":null,"abstract":"<p><p>Peripheral artery disease (PAD) is a prevalent and progressive atherosclerotic condition associated with high cardiovascular and limb-related morbidity and mortality. While pharmacological and revascularisation strategies form the cornerstone of PAD management, the role of nutrition is less clearly defined despite its well-established effects in coronary artery disease and cardiovascular prevention. In this narrative review, we explore the current evidence linking diet and nutrition to the prevention and management of PAD across its clinical spectrum, from asymptomatic disease to chronic limb-threatening ischaemia. We summarise findings on dietary patterns (e.g. Mediterranean diets), food groups, nutrients, fibre, and bioactives such as flavonoids. The available evidence supports that healthy dietary patterns may reduce PAD risk and improve outcomes, with effect sizes comparable to some pharmacological interventions. Most people with asymptomatic and symptomatic PAD do not adhere to healthy dietary patterns. Undernutrition as captured by indices such as the Geriatric Nutritional Risk Index is prevalent in advanced PAD and independently associated with complication and poor postoperative outcome. Despite this, most PAD patients do not receive dietary counselling, and few clinical studies have directly evaluated nutritional interventions in PAD populations. Given its low cost, safety, and potential for meaningful impact, dietary modification represents an underused but promising strategy in PAD prevention and treatment. Future research should prioritise PAD-specific dietary intervention trials and strategies for integrating nutrition into vascular care pathways.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerometer-Measured Physical Activity Timing and Risk of Incident Atrial Fibrillation: A UK Biobank Cohort Study.","authors":"Qingling Zhang, Luoxuan Fu, Jinhua Zhao, Kangyin Chen, Gary Tse, Gregory Y H Lip, Tong Liu","doi":"10.1093/eurjpc/zwaf604","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf604","url":null,"abstract":"<p><strong>Introduction: </strong>Although moderate-to-vigorous physical activity (MVPA) is linked to a lower risk of atrial fibrillation (AF), the influence of its timing on AF outcomes remains largely understudied.</p><p><strong>Methods: </strong>Accelerometer-derived MVPA data from UK Biobank participants free of AF at baseline were used to examine associations between distinct MVPA timing patterns (inactive, morning, afternoon, evening, mixed) and incident AF risk, estimated via multivariable-adjusted Cox proportional hazards models.</p><p><strong>Results: </strong>A total of 88,024 participants (57.4% female) were followed for a median of 7.87 years, during which 3,815 developed incident AF. In the fully adjusted Cox model, engaging in MVPA in the morning, afternoon, or at mixed times was associated with lower AF risk, compared with inactivity. The morning activity group showed the greatest risk reduction (HR = 0.79; 95% confidence interval [CI]: 0.70-0.89; p < 0.001). Stratified analyses revealed that adults < 65 years benefited most from morning exercise. For diabetics, morning and afternoon MVPA were protective (HR 0.66, p = 0.001; HR 0.77, p = 0.025). Among non-diabetics, evening activity offered the greatest benefit (HR 0.76, p = 0.029). In non-hypertensive individuals, the timing of activity made little difference. However, among patients with hypertension, engaging in activity at any time of day was associated with a reduced risk of atrial fibrillation, with the greatest benefit observed in the morning (HR = 0.74, p < 0.001).</p><p><strong>Conclusion: </strong>Regular MVPA at any time was associated with lower AF risk, with exploratory evidence suggesting greater benefit in the morning, particularly among younger adults and those with comorbidities.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension management in the elderly and the very elderly.","authors":"Luigina Guasti, Giuseppe Derosa, Stefano Fumagalli, Marc Ferrini, Riccardo Asteggiano","doi":"10.1093/eurjpc/zwaf194","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf194","url":null,"abstract":"<p><p>Hypertension increases with age, with a very high prevalence in older patients. Since hypertension is a major contributor of cardiovascular diseases, this condition accounts for the majority of stroke and a relevant number of coronary artery disease cases in the older adults. Ageing is associated with frailty and multimorbidity, often associated with polypharmacy, which may complicate the management of hypertension. Specific diseases like diabetes and Parkinson disease associated with autonomic dysfunctions, and the frail condition, should be carefully considered in order to avoid orthostatic hypotension. Aortic stenosis, cardiac hypertrophy, heart failure, reduced glomerular filtration rate, arrhythmias such as atrial fibrillation, obstructive coronaropathies and cerebral vascular lesions constitute hemodynamic challenges and may be associated with increased adverse effects during anti-hypertensive treatments. Moreover, specific drugs and drug-drug interactions are associated with sides effects particularly deleterious in the older patients. The worsening of the state of health and the increase in the degree of frailty can result either as a consequence of target-organ-damage related to hypertension or caused by antihypertensive drugs. Therefore, in the older adults, a careful assessment of the individual risk/benefit profile and a personalized view of the patient is necessary to establish the appropriate blood pressure targets and the appropriate treatments.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"Lipidogram for a first-grade student\" - screening for premature cardiovascular risk factors in children of Zabrze, Poland.","authors":"Krzysztof Dyrbuś, Beata Chodór, Maciej Dyrbuś, Zofia Mędrala, Karolina Konsek, Natalia Nafalska, Małgorzata Stopyra, Michał Krawiec, Dominik Bełz, Krzysztof Feret, Krystyna Czapla, Marzena Reguła, Anna Gibas, Alicja Chachaj, Przemysław Trzeciak, Alicja Grzanka, Maciej Banach, Piotr Przybyłowski, Mariusz Gąsior","doi":"10.1093/eurjpc/zwaf603","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf603","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peak atrial longitudinal strain to catch atrial fibrillation in patients in sinus rhythm admitted for cerebral ischemic events.","authors":"Giacomo Gamberini, Paolo Fabio D'Andria, Giulio P F Mallardi, Filippo Toriello, Massimo Saviano, Maria Teresa Lamanna, Francesco Moda, Laura Garau, Ilaria Trolese, Andrea Faggiano, Sara Bonato, Isabella Ghione, Silvia Lanfranconi, Marco Vicenzi, Stefano Carugo, Massimiliano Ruscica, Gloria Santangelo","doi":"10.1093/eurjpc/zwaf608","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf608","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}