European journal of preventive cardiology最新文献

{"title":"Greenspace visitation and risk of major adverse cardiovascular events: evidence from the Houston methodist cardiovascular learning health system registry.","authors":"Weichuan Dong, Sarayu Chandra Mouli, Izza Shahid, Rakesh Gullapelli, Budhaditya Bose, Tong Zhang, Jad Ardakani, Juan C Nicolas, Zulqarnain Javed, Kai Zhang, Zhuo Chen, Sanjay Rajagopalan, Jay Maddock, Khurram Nasir, Sadeer Al-Kindi","doi":"10.1093/eurjpc/zwag470","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag470","url":null,"abstract":"<p><strong>Aims: </strong>To evaluate whether mobility-derived greenspace visitation, as a behavioural measure of environmental exposure, is associated with major adverse cardiovascular events (MACE) independent of individual and neighbourhood factors.</p><p><strong>Methods and results: </strong>We conducted a retrospective cohort study of adults in the Houston Methodist Cardiovascular Disease Learning Health System Registry (2016-2023). Greenspace visitation was defined at the census-tract level using mobility-derived foot-traffic data and modelled as annual visits per resident device. The primary outcome was incident MACE (myocardial infarction, stroke, coronary revascularization, and all-cause mortality). The Cox models, restricted cubic splines, and Kaplan-Meier curves assessed associations with sequential adjustment for demographics, comorbidities, smoking, and neighbourhood social vulnerability. Among 1 088 866 adults without baseline atherosclerotic cardiovascular disease, median (SD) age was 49 (17.6) years, and 59.9% were female. Greenspace visitation varied across neighbourhoods and by demographic and socioeconomic characteristics. Each additional 10 annual visits was associated with lower MACE risk in unadjusted models [hazard ratio (HR) 0.82; 95% confidence interval (CI): 0.81-0.83] and after adjustment for demographics, comorbidities, and smoking (HR 0.89; 95% CI: 0.88-0.91). A non-linear relationship showed risk reductions at low-to-moderate visitation, plateauing at 10-15 visits annually. After adjusting for social vulnerability, associations were attenuated and no longer significant. The Kaplan-Meier curves showed higher event-free survival in high-visitation areas, consistent across MACE components.</p><p><strong>Conclusion: </strong>Mobility-derived greenspace visitation is associated with lower cardiovascular risk. These findings highlight greenspace engagement as a potentially modifiable behavioural exposure and support strategies to enhance access and utilization of greenspaces for cardiovascular prevention.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temperature-Attributable Cardiovascular Mortality in Europe Under Future Climate Scenarios: Projected Impacts of Population Aging and Climate Change to 2080.","authors":"Gokul Parameswaran, Sai Rahul Ponnana, Santosh K Sirasapalli, Feriel Presswalla, Niketh Surya, Tong Zhang, Zhuo Chen, Jean-Eudes Dazard, Weebearb J Requia, Mark Nieuwenhuijsen, Thomas Münzel, Salil V Deo, Sanjay Rajagopalan","doi":"10.1093/eurjpc/zwag533","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag533","url":null,"abstract":"<p><strong>Aims: </strong>Heat and cold stress are established cardiovascular risk factors. As climate patterns shift and Europe's population ages, quantifying their separate attributable fractions-and projecting future temperature-attributable cardiovascular disease (tCVD) burden-is essential for clinical and policy decision-making.</p><p><strong>Methods: </strong>Europe was divided into a 0.25° × 0.25° grid (12,411 land cells across 37 countries). Annual cardiovascular disease (CVD) deaths (2016-2023) were downscaled from national estimates using population data. Temperature-mortality relative risk coefficients were drawn from a 27-country pooled study and applied via population attributable fractions with 1,000 Monte Carlo simulations. Daily mean temperature projections from five bias-corrected climate models were obtained under moderate (SSP2-4.5) and high (SSP5-8.5) emission scenarios. Population aging was incorporated using country-level age projections; climate-only analyses held age structure constant at 2020 levels.</p><p><strong>Results: </strong>At baseline, non-optimal temperature accounted for 168,586 [144,961-192,293] CVD deaths annually (31.4 [27.0-35.8] per 100,000), with a cold-to-heat ratio of 5:1. Under SSP5-8.5, total tCVD mortality is projected to nearly double to 62.4 [48.5-76.2] per 100,000 by late-century (441,772 [343,627-540,116] annual deaths), with heat-attributable rates projected to rise 472%. Population aging may amplify total projected mortality by over 80% by late century beyond climate change alone; without aging, cold-attributable rates may decline over the century rather than rise.</p><p><strong>Conclusions: </strong>tCVD mortality across Europe is projected to double by late-century, driven by dramatic heat increases and substantially amplified by population aging. These findings support greater integration of temperature-related CVD risk into clinical practice and public health policy.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical reflections on the non-Lp(a) apoB/Lp(a) ratio.","authors":"Antonio Meseguer-Hernández, Francisco Buendía-Santiago, José Manuel Andreu-Cayuelas","doi":"10.1093/eurjpc/zwag549","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag549","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk-weighted apoB and lipoprotein-associated coronary risk across ethnic groups.","authors":"Michaela B Rehman, Elias Björnson","doi":"10.1093/eurjpc/zwag547","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag547","url":null,"abstract":"<p><strong>Aims: </strong>Apolipoprotein B (apoB) reflects the number of circulating atherogenic lipoproteins but does not account for differences in particle atherogenicity. Risk-weighted apoB (RW-apoB), which incorporates triglyceride-rich lipoproteins and lipoprotein(a) (Lp(a)), may better capture lipoprotein-driven coronary risk, but its performance across diverse populations remains uncertain. We assessed whether the prespecified triglyceride - and Lp(a)-weighted information captured by RW-apoB was associated with coronary events beyond apoB and compared the discrimination of RW-apoB and measured apoB across ethnicities.</p><p><strong>Methods: </strong>We analyzed 40,132 participants with 4,509 coronary events from ARIC, CARDIA, MESA, the Framingham Offspring Study, and China Kadoorie Biobank. RW-apoB was calculated using a prespecified equation. Mutually adjusted Cox estimates were pooled within ethnic groups using random-effects meta-analysis. Separate single-marker models compared discrimination. Sensitivity analyses included age and sex adjustment, standardized exposures, hard-events, truncated follow-up, and CKB-specific logistic regression.</p><p><strong>Results: </strong>Mean RW-apoB exceeded apoB by approximately 8 mg/dL in African American and Chinese participants, reflecting higher lipoprotein(a) and triglycerides, respectively. RW-apoB was associated with coronary events conditional on apoB in White, African American, Chinese, and Hispanic participants: hazard ratios per 10 mg/dL were 1.11 (95% CI 1.05-1.18), 1.11 (1.08-1.15), 1.08 (1.05-1.11), and 1.10 (1.01-1.21), respectively. C-indices for RW-apoB versus apoB were 0.630 versus 0.617 in White (P<0.001), 0.606 versus 0.595 in African American (P=0.085), 0.567 versus 0.554 in Chinese (P=0.014), and 0.540 versus 0.535 in Hispanic participants (P=0.756).</p><p><strong>Conclusion: </strong>RW-apoB captured lipoprotein-associated risk beyond measured apoB, with discrimination gains statistically demonstrable in the larger White and Chinese groups.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Interpreting the non-Lp(a) apoB to Lp(a) ratio in coronary plaque phenotypes.","authors":"Sotirios Tsimikas, Gregg W Stone, David Erlinge","doi":"10.1093/eurjpc/zwag543","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag543","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of RSVpreF Vaccination According to Cardio-Kidney-Metabolic Overlap in Older Adults: A DAN-RSV Trial Analysis.","authors":"Mats C H Lassen, Niklas Dyrby Johansen, Sine H Christensen, Negar Aliabadi, Kristoffer G Skaarup, Daniel Modin, Brian L Claggett, Carsten S Larsen, Lykke Larsen, Lothar Wiese, Michael Dalager-Pedersen, Matias G Lindholm, Anne Marie R Jensen, Maria Dons, Katrine F Bernholm, Filip S Davidovski, Lisa S Duus, Camilla I Ottosen, Anne B Nielsen, Julie H Borchsenius, Caroline Espersen, Güldas Köse, Frederik H Fussing, Lars Køber, Scott D Solomon, Jens Ulrik Stæhr Jensen, Cyril Jean-Marie Martel, Bradford D Gessner, Claudia Schwarz, Mette Skovdal, Pingping Zhang, Elizabeth Begier, Tor Biering-Sørensen","doi":"10.1093/eurjpc/zwag525","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag525","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149192336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interpreting the non-Lp(a) apoB to Lp(a) ratio in coronary plaque phenotypes.","authors":"Hui Luo, Ting Ye","doi":"10.1093/eurjpc/zwag536","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag536","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in cardiovascular risk factor prevalence in premenopausal and postmenopausal women compared with age-matched men.","authors":"Diane Mansencal, Nicolas Mansencal, Katiuska Miliani, Marion Pepin, Alain Beauchet, Christophe Rodon, Pierre Boisson de Chazournes, Clément Marcel, Loïc Josseran, Olivier Dubourg, Marie Hauguel-Moreau","doi":"10.1093/eurjpc/zwag357","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag357","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149192297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Colchicine on Arterial Stiffness in Patients With Hypertension: The COlchicine HypERtENsion Trial (COHERENT).","authors":"Adam Femerling Langhoff, Niklas Dyrby Johansen, Katja Vu Bartholdy, Julie Inge-Marie Helene Borchsenius, Filip Søskov Davidovski, Lise Witten Davodian, Maria Dons, Lisa Steen Duus, Caroline Espersen, Frederik Holme Fussing, Anne Marie Reimer Jensen, Mats Christian Højbjerg Lassen, Camilla Ikast Ottosen, Morten Sengeløv, Kristoffer Grundtvig Skaarup, Anne Bjerg Nielsen, Güldas Köse, Nino Emanuel Landler, Marat Yafasov, Jakob Øystein Simonsen, Daniel Modin, Marie Frimodt-Møller, Tina Ken Schramm, Ahmad Sajadieh, Tor Biering-Sørensen, Thomas Jepps","doi":"10.1093/eurjpc/zwag527","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag527","url":null,"abstract":"<p><strong>Aim: </strong>This trial investigated whether colchicine, an anti-inflammatory treatment, affects cardiovascular structure and function, assessed by arterial stiffness, blood pressure and biochemistry, compared with placebo.</p><p><strong>Methods: </strong>COHERENT was a randomized, double-blind, placebo-controlled trial of the effects of colchicine on arterial stiffness in adults with pharmacologically treated hypertension without cardiovascular disease. Eligible patients were randomized 1:1 to colchicine 0.5mg daily or placebo for six months. Assessment of arterial stiffness, echocardiography, and biomarker measurement were performed at baseline and six months. The primary endpoint was change in carotid-femoral pulse wave velocity (cfPWV). Secondary endpoints included change in blood pressure (BP), left ventricular mass index, as well as change in cardiac and inflammatory biomarkers.</p><p><strong>Results: </strong>Of 183 screened, 150 were randomized (75 per group). Mean age was 64.5 (±8.0) years, 53 (35.3%) were female, and mean systolic blood pressure was 137.6 (±15.6) mmHg. At six months, cfPWV did not differ between groups (between-group difference in ΔcfPWV -0.1m/s, 95% CI: -0.5 to 0.3m/s, p=0.53). Office systolic BP decreased significantly more in the placebo group than in the colchicine group (between-group difference in Δoffice systolic BP 5.7 mmHg, 95% CI: 1.0 to 10.5 mmHg, p=0.018. hsCRP decreased significantly in the colchicine group compared with the placebo group (between-group difference in % change in hsCRP -39.8%, 95% CI: -59.1 to -11.4%, p=0.010). Left ventricular mass index or cardiac biomarkers did not differ between groups.</p><p><strong>Conclusions: </strong>Six months of colchicine did not affect arterial stiffness in pharmacologically treated hypertension without cardiovascular disease. Colchicine significantly decreased hsCRP.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149192347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining Care Pathways for MINOCA: Lessons from the DOMINO Registry.","authors":"Nathaniel R Smilowitz, Harmony R Reynolds","doi":"10.1093/eurjpc/zwag530","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag530","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149192312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}