European journal of preventive cardiology最新文献

{"title":"Gender equity and cardiovascular disease: hypertensive disorders of pregnancy as an under-recognized cardiovascular risk factor.","authors":"Amitava Banerjee","doi":"10.1093/eurjpc/zwaf326","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf326","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal intake of dietary protein from plant and animal sources and development of pharmacologically treated hypertension within 10 years after pregnancy.","authors":"Jannike Øyen, Anne Lise Brantsæter, Lene Secher Myrmel, Hanne Rosendahl-Riise, Ottar Nygård, Eva Gerdts, Lise Madsen, Grace M Egeland","doi":"10.1093/eurjpc/zwaf343","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf343","url":null,"abstract":"<p><strong>Aims: </strong>To investigate associations between intake of protein from plant and animal sources and risk of development of pharmacologically treated hypertension (defined as antihypertensive medication usage >90 days after delivery) in a large population of Norwegian mothers followed up to 10 years after delivery.</p><p><strong>Methods: </strong>Women in the Norwegian Mother, Father and Child Cohort Study (MoBa) recruited between 2004-2008 were linked to the Norwegian Prescription Database (2004-2013) to ascertain antihypertensive medication usage. Women with hypertension before pregnancy were excluded, leaving 59,967 mothers for analyses. Diet was assessed by a validated semiquantitative food frequency questionnaire in mid-pregnancy. Cox proportional hazard analyses evaluated HRs and 95% CIs for quintiles of intake in multivariable models.</p><p><strong>Results: </strong>A total of 1,480 (2.5%) women developed hypertension within 10 years of follow-up. Intake of protein from dairy, particularly milk/yoghurt, was inversely associated with hypertension (HR for highest vs. lowest milk/yoghurt quintile: 0.76, 95% CI 0.65, 0.89, P-trend < 0.001). Intake of red meat protein was positively associated with hypertension (HR for quintile four vs. quintile one: 1.27, 95% CI 1.07, 1.51, P-trend = 0.010). No significant associations were observed for plant-based protein sources.</p><p><strong>Conclusions: </strong>The findings suggest that intake of protein from dairy sources is inversely associated with hypertension, while protein from red meat is positively associated with developing hypertension up to ten years after pregnancy. This study provides novel contributions to the literature by examining the impact of a diverse array of plant and animal protein sources on the risk of hypertension in women.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Gene-Activity Interplay in Cardiovascular Disease: Is Feasible to Mitigate Genetic Risk Through Physical Activity?","authors":"Rodrigo Núñez-Cortés, Laura Joensuu, José Francisco López-Gil, Joaquín Calatayud, Fanny Petermann-Rocha, Lars Louis Andersen, Elina Sillanpää, Rubén López-Bueno","doi":"10.1093/eurjpc/zwaf348","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf348","url":null,"abstract":"<p><p>Genetic factors can influence cardiovascular disease (CVD) risk through multiple behavioral and physiological mechanisms, including lipid metabolism, blood pressure regulation, and inflammatory responses. The present narrative review examines the impact of physical activity on the relationship between genetic susceptibility and CVD risk. Specifically, we synthesize evidence regarding gene-physical activity interplay and whether individuals with a genetic predisposition for CVD benefit more from physical activity than individuals with more health-favorable genotypes. Most single-gene studies on gene-physical activity interactions have shown that physical activity can significantly reduce CVD risk also in individuals with high genetic predisposition for CVD. Those with higher genetic risk may experience more substantial benefits from physical activity than those with lower genetic risk. Additionally, genetics may play a role in how people respond to exercise and why some people find it harder to adopt a healthy lifestyle. The evidence showed the central role of physical activity in reducing the CVD risk across different genetic profiles, highlighting the need for personalized preventive strategies to optimize cardiovascular health.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimating the health impact of menu calorie labelling policy and sugar-sweetened beverage taxation in two European countries: a microsimulation study.","authors":"I Gusti Ngurah Edi Putra, Martin O'Flaherty, Karl M F Emmert-Fees, Maria Salve Vasquez, Rebecca Evans, Annette Peters, Chris Kypridemos, Nicolas Berger, Eric Robinson, Zoé Colombet","doi":"10.1093/eurjpc/zwaf333","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf333","url":null,"abstract":"<p><strong>Aims: </strong>To estimate and compare the impacts of menu calorie labelling and sugar-sweetened beverage (SSB) taxation on reducing obesity prevalence, cardiovascular disease (CVD) mortality, and equity-related impacts, in Belgium and Germany.</p><p><strong>Methods: </strong>We used microsimulation models over a 20-year simulation horizon (2022-2041). We modelled the impacts through assumed changes in energy intake due to consumer responses and food industry reformulation. Scenarios of partial (in \"large\" out-of-home businesses; ≥ 250 employees) and full (in all out-of-home businesses) implementation for menu calorie labelling and different tax rates for SSBs (10%, 20%, 30%) were simulated.</p><p><strong>Results: </strong>Compared to the counterfactual scenario, assuming effects on both consumer and industry behaviour, menu calorie labelling applied to all out-of-home businesses was estimated to reduce obesity prevalence by 3·61 (95% uncertainty interval-UI: [2·78, 4·30]) and 4·28 (95% UI: [3·64, 5·06]) percentage points and prevent 1600 (95% UI: [400, 3800]) and 30000 (95% UI: [10000, 58000]) CVD deaths in Belgium and Germany over 20 years, respectively. The 30% SSB tax was estimated to reduce obesity prevalence by 0·27 (95% UI: [0·17, 0·43]) and 0·27 (95% UI: [0·17, 0·39]) percentage points and postpone 2500 (95% UI: [800, 5200]) and 16000 (95% UI: [7500, 28000]) CVD deaths in Belgium and Germany, respectively. In both countries, SSB taxation had a larger impact on CVD deaths for lower (vs. higher) education groups, whereas calorie labelling prevented more CVD deaths for higher (vs. lower) education groups.</p><p><strong>Conclusions: </strong>Menu calorie labelling and SSB taxation have substantial impacts on reducing obesity prevalence and preventing CVD deaths in Belgium and Germany. Implementing both policies will be important to tackle obesity and CVD burden.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rationale for the Routine Screening of Lipoprotein (a) in Cardiovascular Risk Assessment.","authors":"Iulia Iatan, Marlys L Koschinsky, Logan Trenaman, Wei Zhang, George Thanassoulis, Liam R Brunham, G B John Mancini, Gordon A Francis","doi":"10.1093/eurjpc/zwaf342","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf342","url":null,"abstract":"<p><p>Lipoprotein(a) [Lp(a)] is a lipid particle identified by Mendelian randomization studies to be causally associated with the development of atherosclerotic cardiovascular disease and aortic stenosis, across ethnicities. The risk of cardiovascular disease with markedly elevated Lp(a) is equal to that of untreated familial hypercholesterolemia, and yet, up until now, there has been hesitancy in measuring Lp(a) as a routine part of cardiovascular risk assessment. Screening of Lp(a) level in all individuals is now recommended in the European and Canadian Lipid Guidelines and by the National Lipid Association. This review assesses how well measurement of Lp(a) meets accepted criteria for population screening of an analyte, based on established principles used for the selection of a new candidate for inclusion in screening programs. Lp(a) meets the majority of recommended principles for a routine population screening test, based on health, societal, and cost considerations. Incorporating Lp(a) into global assessment and management of cardiovascular risk will result in savings to health care systems, reinforce recommendations from growing numbers of clinical guidelines and consensus statements, and increase implementation of proactive preventive medicine.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Colchicine for Secondary Prevention in Established ASCVD: A Systematic Review and Meta-Analysis.","authors":"Ahmed Abdelaziz, Ahmed Sobhy, Ahmed Nazmy, Karim Atta, Ahmed Elshahat, Mohamed Abdelaziz, Daniel Lorenzatti, Ashley Radparvar, Toshiki Kuno, Annalisa Filtz, Carl J Lavie, Martha Gulati, Deepak L Bhatt, Salim S Virani, Michael D Shapiro, Leandro Slipczuk","doi":"10.1093/eurjpc/zwaf332","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf332","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Efficacy of LDL-C-Lowering Therapies in First-time versus Recurrent Myocardial Infarction Prevention: A Meta-Analysis of Large-scale Randomized Controlled Trials.","authors":"Bao-Qiang Guo, Hong-Bin Li, Bing Zhao, Peng-Wei Xu","doi":"10.1093/eurjpc/zwaf336","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf336","url":null,"abstract":"<p><strong>Aims: </strong>Reducing elevated low-density lipoprotein cholesterol (LDL-C) is central to global efforts to prevent myocardial infarction (MI). While many studies have evaluated LDL-C-lowering therapies in first-time and recurrent MI prevention, direct comparisons of their relative efficacy are lacking. Therefore, we conducted a systematic review and meta-analysis to compare the efficacy of LDL-C-lowering therapies in first-time versus recurrent MI prevention.</p><p><strong>Methods: </strong>We searched three databases until November 30, 2024, for randomized controlled trials (RCTs) with at least 1,000 patient-years of follow-up. Efficacy was quantified as relative risk (RR) with 95% confidence intervals (CIs). Differences in benefit magnitude were assessed using Cochran's Q test. Data were pooled with a random-effects model, and heterogeneity was measured using the I2 statistic. Additionally, we applied the Cochrane Risk of Bias Tool to evaluate study quality and utilized the GRADE method to assess the certainty of the evidence.</p><p><strong>Results: </strong>This study included 22 large-scale RCTs involving 180,304 participants. In first-time MI prevention, LDL-C-lowering therapies achieved a remarkable 38% reduction in MI risk (12 RCTs; 79,604 participants; RR, 0.62 [95% CI, 0.55-0.69]; P <0.001). In recurrent MI prevention, these therapies were associated with a more modest but significant 16% risk reduction (11 RCTs; 100,700 participants; RR, 0.84 [95% CI, 0.80-0.88]; P <0.001). Importantly, the benefit magnitude between the two groups was significantly different (Q=22.63; P <0.001), highlighting the greater relative benefit in first-time MI prevention. Furthermore, the robustness of our findings was consistently supported by leave-one-out analyses, the absence of publication bias, high-quality GRADE evidence, and subgroup and sensitivity analyses.</p><p><strong>Conclusion: </strong>Our findings suggest that LDL-C-lowering therapies may offer a greater benefit in preventing first-time MI compared to recurrent MI.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prescribing sleep, provoking harm? rethinking Z-drugs in heart failure.","authors":"Charles Fauvel, Iana Simova","doi":"10.1093/eurjpc/zwaf277","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf277","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steatotic Liver Disease as a Risk Enhancer in the Presence of Metabolic Syndrome.","authors":"Guyu Zeng, Peizhi Wang, Weiwei Xu, Qinxue Li, Tianyu Li, Yue Tian, Bochuan Huang, Diederick Grobbee, Manuel Castro Cabezas, Jinqing Yuan","doi":"10.1093/eurjpc/zwaf330","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf330","url":null,"abstract":"<p><strong>Background & aims: </strong>Steatotic liver disease (SLD) is an overarching term to encompass metabolic-dysfunction associated steatotic liver disease (MASLD), MASLD with increased alcohol intake (MetALD), and alcohol-associated liver disease (ALD). However, the impact of metabolic syndrome (MetS) on the association between SLD and mortality risk remains uncertain. This study aims to compare all-cause and cause-specific mortality across SLD subtypes stratified by MetS.</p><p><strong>Methods: </strong>A population-based cohort study was conducted using NHANES Ⅲ data, including 9,217 participants stratified by MetS status and further categorized into no SLD, MASLD, MetALD, and ALD groups. MetS was defined according to the International Diabetes Federation criteria.</p><p><strong>Results: </strong>Over a median follow-up of 26.4 years, 3,521 mortality events occurred. After adjustment, SLD with MetS was significantly associated with an increased risk of all-cause mortality compared with healthy controls (HR 1.56, 95% CI 1.38-1.75). This association persisted across all SLD subtypes (MASLD: HR 1.52, 95% CI 1.34-1.72; MetALD: HR 1.92, 95% CI 1.41-2.62; ALD: HR 2.80, 95% CI 1.56-5.05). In contrast, no significant association was found between SLD subtypes without MetS and mortality risk. When stratified by MetS presence, MASLD, MetALD and ALD were each significantly associated with increased mortality risks compared to the no SLD group in individuals with MetS, primarily driven by high cancer-related and diabetes-related mortality. However, this association was not observed in the population without MetS.</p><p><strong>Conclusions: </strong>This study reveals that the significant association between SLD subtypes and mortality risk is mediated by MetS. To enhance risk stratification and improve long-term health outcomes, it is crucial to distinguish between MASLD, MetALD, and other SLD types while managing metabolic status and reducing alcohol consumption.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone mineral loss and risk of atrial fibrillation: A multicohort study.","authors":"Qingwei Yu, Yihu Yi, Yalan Li, Jie Wang, Shiqi Liu, Jun Lu, Chenxi Ouyang, Xiaoxiao Zhong, Hong Yuan, Yao Lu","doi":"10.1093/eurjpc/zwaf346","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf346","url":null,"abstract":"<p><strong>Aims: </strong>Existing evidence has supported a correlation between osteoporosis and vascular damage conditions, yet studies investigating heart rhythm dysfunction are scarce. This study aimed to explore the link between osteoporosis and atrial fibrillation (AF), with a particular focus on the potential role of genetic predisposition, sex, and circulating proteins.</p><p><strong>Methods: </strong>This population-based study included 495 549 participants from three independent cohorts. Cox proportional hazard models were conducted separately for each cohort and combined in a random-effect meta-analysis to determine the association between osteoporosis and AF. The role of genetic susceptibility, sex, and circulating proteins was further assessed in osteoporosis-related AF by integrating phenotype, gene, and protein data. The predictive performance was assessed via receiver operating characteristic (ROC) curves.</p><p><strong>Results: </strong>Compared with individuals without osteoporosis, individuals with osteoporosis experienced an elevated risk of AF (HR 1.38, 95% CI 1.01-1.89), independent of AF-related genetic susceptibility. Moreover, an obvious sex disparity was present in the osteoporosis-AF relationship in the primary cohort, with a higher risk of AF for osteoporosis males (HR 1.30, 95% CI 1.11-1.51 for males; HR 1.16, 95% CI 1.04-1.28 for females). 19 proteins were indicated to contribute to the relationship between osteoporosis and increased AF risk, with LMNB2 improving the predictive accuracy for the incidence of AF.</p><p><strong>Conclusion: </strong>This research revealed an increased risk of AF in individuals with osteoporosis, especially in males. These findings highlight the need for regular heart rhythm monitoring in osteoporosis individuals, with LMNB2 potentially being a candidate marker for predicting AF incidence.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144283120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}