European journal of preventive cardiology最新文献

{"title":"Walking Speed and Mortality in Cardiovascular Rehabilitation: A Critical Appraisal of Study Design and Interpretability.","authors":"Liyao Su, Yongmei Jin","doi":"10.1093/eurjpc/zwaf362","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf362","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Large-Scale Plasma Proteomics for Prediction of Heart Failure in Individuals with A Full Range of Glucose Metabolism Profiles.","authors":"Yujie Zhang, Rui Hou, Wen Sun, Jin Guo, Zhiguo Chen, Haibin Li, Changwei Li, Lijuan Wu, Jianguang Ji, Deqiang Zheng","doi":"10.1093/eurjpc/zwaf381","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf381","url":null,"abstract":"<p><strong>Aims: </strong>Individuals with abnormal glucose metabolism are at a significantly higher risk of developing heart failure (HF). However, strategies for early identification of HF in this high-risk population remain inadequate. This study aimed to identify plasma protein biomarkers associated with HF development and construct predictive models to identify at-risk individuals.</p><p><strong>Methods: </strong>We analyzed HF development in abnormal glucose metabolism population using data from 6,517 participants in discovery cohort and 2,783 in validation cohort, all from the UK Biobank, with no prior history of HF. Proteomic profiling was performed, and Lasso-Cox regression was used to identify protein associations, followed by Cox regression to develop predictive models. The model incorporated four proteins (NTproBNP, LTBP2, REN, GDF15) and clinical factors to create a protein-panel-clinical-factors (PPCF) model. For comparison, the model's performance was also evaluated in individuals with normal glucose metabolism.</p><p><strong>Results: </strong>Over a median follow-up of 13.90 years, 555 incident HF cases were recorded in discovery cohort. The PPCF model achieved an AUC of 0.823 (95% CI: 0.785 - 0.860) in validation cohort, improving predictive performance by 0.05 (P < 0.001) compared to clinical factors-only model. In general population of 23,107 individuals, PPCF model obtained an AUC of 0.807 (95% CI: 0.786 - 0.829). Both protein panel model and PPCF model demonstrated superior net benefits over clinical factors model in abnormal glucose metabolism population.</p><p><strong>Conclusion: </strong>This study identified plasma protein biomarkers linked to HF development in abnormal glucose metabolism population and established the predictive models. These findings support early identification in high-risk populations.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remnant cholesterol, the cardiovascular-kidney-metabolic syndrome, and cardiovascular disease: Lessons from CHARLS.","authors":"Marcio Miname, Raul D Santos","doi":"10.1093/eurjpc/zwaf345","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf345","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statin use for primary prevention of cardiovascular disease among apparently healthy adults.","authors":"Andrim Halili, Talip E Eroglu, Christian Torp-Pedersen, Bochra Zareini","doi":"10.1093/eurjpc/zwaf357","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf357","url":null,"abstract":"<p><strong>Objective: </strong>To study the association between statin adherence and the 5-year risk of major cardiovascular events among apparently healthy individuals.</p><p><strong>Methods and results: </strong>A nationwide cohort study utilising national registries in Denmark was conducted. All apparently healthy individuals aged 40-85 years using statins for one year between 1997 and 2022 with no personal history of cardiovascular diseases, diabetes mellitus, chronic obstructive pulmonary disease, hepatic diseases, cancer, or parents with cardiovascular disease, among other exclusion factors, were included. Statin use was categorized according to adherence by the proportion of days covered with redeemed statin prescriptions: <50% (low), 50-75% (moderate), and 75-100% (high). The primary outcome was a composite of myocardial infarction, stroke, or cardiovascular death. The 5-year absolute risk was estimated using the Aalen-Johansen estimator while considering competing risks. Additionally, cause-specific Cox proportional hazards models were used to estimate hazard ratios across statin adherence levels.Among 151,791 apparently healthy individuals, low statin adherence was associated with a 5-year major cardiovascular risk of 4.77% (95%-confidence interval 4.18-5.36). For moderate adherence, the 5-year risk was 3.71% (95%-confidence interval 4.18-5.36), and the corresponding hazard ratio was 0.87 (95%-confidence interval 0.75-1.01), while high adherence was associated with the lowest 5-year risk of 3.01% (95%-confidence interval 2.90-3.11), and the corresponding hazard ratio was 0.66 (95%-confidence interval 0.58-0.75).</p><p><strong>Conclusion: </strong>High statin adherence among apparently healthy users was associated with a significant risk reduction of major cardiovascular adverse events.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood violence and adult cardiovascular disease: issues to be addressed.","authors":"Hongyan Pu, Fan Zhang, Huachun Zhang","doi":"10.1093/eurjpc/zwaf360","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf360","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External validation of the Systematic Coronary Risk Evaluation 2 (SCORE2) and SCORE2-Older Persons in cancer patients.","authors":"Mari Nordbø Gynnild, Joris Holtrop, Steven H J Hageman, Victoria Vinje, Jannick A N Dorresteijn, Frank L J Visseren, Espen Holte, Håvard Dalen, Torgeir Wethal, Torbjørn Omland","doi":"10.1093/eurjpc/zwaf356","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf356","url":null,"abstract":"<p><strong>Background: </strong>The 2022 ESC Cardio-oncology guidelines recommend cardiovascular disease (CVD) risk stratification for cancer patients and suggest using SCORE2 and SCORE2-OP. However, these models have not been validated or specifically adapted for cancer populations.</p><p><strong>Aim: </strong>Refinement of SCORE2 and SCORE2-OP models to accurately predict 10-year fatal and non-fatal CVD risk in cancer patients.</p><p><strong>Methods: </strong>We included 1,622 patients from the HUNT3 study (2006-2008) who were diagnosed with cancer within 4 years after their enrollment and followed until 2023 linked to national registries. The primary outcome was a composite of myocardial infarction (MI), stroke, or CVD mortality. Model performance was assessed using Harrel's C-statistic and calibration curves. Both models were recalibrated by applying a multiplicative adjustment factor based on expected-observed (E/O) ratios.</p><p><strong>Results: </strong>The most prevalent cancers were gastrointestinal (23%), prostate (17%), and breast (14%). Mean age was 65.2 years, 52% were female. During a median follow-up of 8.8 years [interquartile range 1.9-12.6], 252 CVD events (39% MI, 36% stroke, 25% CVD deaths) and 708 non-CVD deaths occurred. SCORE2 initially underestimated CVD risk (E/O ratio for men and women: 0.91 and 0.63, respectively) but showed adequate agreement after recalibration. C-statistics for SCORE2 was 0.693 (95% confidence interval (CI) 0.643-0.743), and 0.730 (95% CI 0.676-0.784) after excluding those not surviving the first 2 years. For SCORE2-OP, the C-statistics were 0.586 (95% CI 0.529-0.643) and 0.648 (95% CI 0.577-0.720).</p><p><strong>Conclusions: </strong>SCORE2 underestimated CVD risk in cancer patients. After recalibration, the model may serve as a valuable tool for risk stratification in cancer patients.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic Insights into Heart Failure Prevention: The Role of Ketone Bodies in Multi-Marker Risk Assessment.","authors":"Juan David Coellar, Neil Keshvani, Ambarish Pandey","doi":"10.1093/eurjpc/zwaf334","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf334","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Making a quality diagnosis of familial hypercholesterolaemia in children.","authors":"Gerald F Watts, Jing Pang, Andrew C Martin","doi":"10.1093/eurjpc/zwaf353","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf353","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperglycemia and genetic susceptibility in relation to incident degenerative aortic valve stenosis.","authors":"Chaolei Chen, Zehan Huang, Lin Liu, Bingbing Su, Yingqing Feng, Yuqing Huang","doi":"10.1093/eurjpc/zwaf355","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf355","url":null,"abstract":"<p><strong>Aims: </strong>While the association between diabetes and degenerative aortic valve stenosis (AS) is well established, the relationship between prediabetes and AS remains unclear, and the potential influence of genetic susceptibility on these associations has yet to be explored. We aimed to examine the association between hyperglycemia, including prediabetes and diabetes, and incident degenerative AS and to explore whether genetic susceptibility modify these associations.</p><p><strong>Methods and results: </strong>This population-based cohort study analyzed data from 461,017 UK Biobank participants who were divided into three groups (normoglycemia, prediabetes, and type 2 diabetes) according to their baseline glycemic status. The primary outcome was incident degenerative AS, while the secondary outcome was AS-related events, a composite outcome of AS-related intervention or death due to AS. During a median follow-up of 14.3 years, 5,307 AS and 2,209 AS-related events were documented. Compared with normoglycemia, the adjusted HR (95% CI) for incident AS of prediabetes and diabetes were 1.21 (95% CI, 1.13-1.30) and 1.66 (95% CI, 1.52-1.80), respectively. The corresponding values for incident AS-related events were 1.26 (95% CI, 1.13-1.41) and 1.60 (95% CI, 1.40-1.83), respectively. For the joint associations, participants with prediabetes or diabetes had a higher risk of AS and AS-related events regardless of genetic risk and the highest hazard was observed in those with diabetes and high genetic risk (AS: HR, 3.25, 95% CI, 2.82-3.74; AS-related events: HR, 3.79, 95% CI, 3.05-4.72).</p><p><strong>Conclusion: </strong>Prediabetes, in addition to diabetes, was associated with an increased risk of AS and AS-related events, independent of a genetic risk score for AS.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proposal of a Familial Hypercholesterolemia Pediatric Diagnostic Score (FH-PeDS).","authors":"Jan Kafol, Beatriz Miranda, Rok Sikonja, Jaka Sikonja, Albert Wiegman, Ana Margarida Medeiros, Ana Catarina Alves, Tomas Freiberger, Barbara A Hutten, Matej Mlinaric, Tadej Battelino, Steve E Humphries, Mafalda Bourbon, Urh Groselj","doi":"10.1093/eurjpc/zwaf352","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf352","url":null,"abstract":"<p><strong>Background and aims: </strong>Familial hypercholesterolemia (FH) significantly increases cardiovascular risk from childhood yet remains widely underdiagnosed. This cross-sectional study aimed to evaluate existing pediatric FH diagnostic criteria in real-world cohorts and to develop two novel diagnostic tools: a semi-quantitative scoring system (FH-PeDS) and a machine learning model (ML-FH-PeDS) to enhance early FH detection.</p><p><strong>Methods: </strong>Five established FH diagnostic criteria were assesed (Dutch Lipid Clinics Network [DLCN], Simon Broome, EAS, Simplified Canadian, and Japanese Atherosclerosis Society) in Slovenian (N=1,360) and Portuguese (N=340) pediatric hypercholesterolemia cohorts, using FH-causing variants as the reference standard. FH-PeDS was developed from the Slovenian cohort, and ML-FH-PeDS was trained and tested using a 60%/40% split before external validation in the Portuguese cohort.</p><p><strong>Results: </strong>Only 47.4% of genetically confirmed FH cases were identified by all established criteria, while 10.9% were missed entirely. FH-PeDS outperformed DLCN in the combined cohort (AUC 0.897 vs. 0.857; p<0.01). ML-FH-PeDS showed superior predictive power (AUC 0.932 in training, 0.904 in testing vs. 0.852 for DLCN; p<0.01) and performed best as a confirmatory test in the testing subgroup (39.7% sensitivity, 87.7% PPV at 98% specificity). In the Portuguese cohort, ML-FH-PeDS maintained strong predictive performance (AUC 0.867 vs. 0.815 for DLCN; p<0.01) despite population differences.</p><p><strong>Conclusions: </strong>Current FH diagnostic criteria perform suboptimally in children. FH-PeDS and ML-FH-PeDS provide tools to improve FH detection, particularly where genetic testing is limited. They also help guide genetic testing decisions for hypercholesterolemic children. By enabling earlier diagnosis and intervention, these tools may reduce long-term cardiovascular risk and improve outcomes.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}