European journal of preventive cardiology最新文献_第9页

Cardiopulmonary exercise testing parameters in healthy athletes vs. equally fit individuals with hypertrophic cardiomyopathy. 健康运动员与同样健康的肥厚性心肌病患者的心肺运动试验参数

IF 8.4 2区医学

European journal of preventive cardiology Pub Date : 2025-05-05 DOI: 10.1093/eurjpc/zwaf177

Cliodhna McHugh, Sarah K Gustus, Bradley J Petek, Mark W Schoenike, Kevin S Boyd, Jasmine B Kennett, Carolyn VanAtta, Albree F Tower-Rader, Michael A Fifer, Marcelo F DiCarli, Meagan M Wasfy

{"title":"Cardiopulmonary exercise testing parameters in healthy athletes vs. equally fit individuals with hypertrophic cardiomyopathy.","authors":"Cliodhna McHugh, Sarah K Gustus, Bradley J Petek, Mark W Schoenike, Kevin S Boyd, Jasmine B Kennett, Carolyn VanAtta, Albree F Tower-Rader, Michael A Fifer, Marcelo F DiCarli, Meagan M Wasfy","doi":"10.1093/eurjpc/zwaf177","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf177","url":null,"abstract":"Aims: Cardiopulmonary exercise testing (CPET) is often used when athletes present with suspected hypertrophic cardiomyopathy (HCM). While low peak oxygen consumption (pV˙O2) augments concern for HCM, athletes with HCM frequently display supranormal pV˙O2, which limits this parameter's diagnostic utility. We aimed to compare other CPET parameters in healthy athletes and equally fit individuals with HCM.Methods and results: Using cycle ergometer CPETs from a single centre, we compared ventilatory efficiency and recovery kinetics between individuals with HCM [percent predicted pV˙O2(ppV˙O2) > 80%, non-obstructive, no nodal agents] and healthy athletes, matched (2:1 ratio) for age, sex, height, weight and ppV˙O2. Consistent with matching, HCM (n = 30, 43.6 ± 14.2 years) and athlete (n = 60, 43.8 ± 14.9 years) groups had similar, supranormal pV˙O2 (39.5 ± 9.1 vs. 41.1 ± 9.1 mL/kg/min, 125 ± 26 vs. 124 ± 25% predicted). Recovery kinetics were also similar. However, HCM participants had worse ventilatory efficiency, including higher early V˙E/V˙CO2 slope (25.4 ± 4.7 vs. 23.4 ± 3.1, P = 0.02), higher V˙E/V˙CO2 nadir (27.3 ± 4.0 vs. 25.2 ± 2.6, P = 0.004) and lower end-tidal CO2 at the ventilatory threshold (42.9 ± 6.4 vs. 45.7 ± 4.8 mmHg, P = 0.02). HCM participants were more likely to have abnormally high V˙E/V˙CO2 nadir (>30) than athletes (20 vs. 3%, P = 0.02).Conclusion: Even in the setting of similar and supranormal pV˙O2, ventilatory efficiency is worse in HCM participants vs. healthy athletes. Our results demonstrate the utility of CPET beyond pV˙O2 assessment in 'grey zone' athlete cases in which the diagnosis of HCM is being debated.","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Passive registers are not enough to improve preventive cardiovascular care. 被动登记不足以改善心血管预防保健。

IF 8.4 2区医学

European journal of preventive cardiology Pub Date : 2025-05-02 DOI: 10.1093/eurjpc/zwaf256

David A Wood

引用次数: 0

GLP-1 analogues and prevention of atrial fibrillation: clinical and mechanistic insights. GLP-1类似物和房颤的预防：临床和机制的见解。

IF 8.4 2区医学

European journal of preventive cardiology Pub Date : 2025-04-30 DOI: 10.1093/eurjpc/zwaf242

Qing-Wen Ren, Kai-Hang Yiu

引用次数: 0

Cardiovascular Outcomes in Adults with Low-Density Lipoprotein Cholesterol Levels of ≥4.9 mmol/L: 15-Year Follow-up of the CoLaus|PsyCoLaus Study. 低密度脂蛋白胆固醇水平≥4.9 mmol/L的成人心血管结局：CoLaus|PsyCoLaus研究的15年随访

IF 8.4 2区医学

European journal of preventive cardiology Pub Date : 2025-04-30 DOI: 10.1093/eurjpc/zwaf268

Lucy Bolt, Stéphanie Baggio, Julian Teuscher, Roxane de La Harpe, Julien Vaucher, Pedro Marques-Vidal, Drahomir Aujesky, Nicolas Rodondi, Elisavet Moutzouri

{"title":"Cardiovascular Outcomes in Adults with Low-Density Lipoprotein Cholesterol Levels of ≥4.9 mmol/L: 15-Year Follow-up of the CoLaus|PsyCoLaus Study.","authors":"Lucy Bolt, Stéphanie Baggio, Julian Teuscher, Roxane de La Harpe, Julien Vaucher, Pedro Marques-Vidal, Drahomir Aujesky, Nicolas Rodondi, Elisavet Moutzouri","doi":"10.1093/eurjpc/zwaf268","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf268","url":null,"abstract":"Aims: Guidelines recommend lipid-lowering treatment (LLT) in all adults with low-density lipoprotein cholesterol (LDL-C) ≥4.9 mmol/L independently of a genetic diagnosis or other cardiovascular risk factors, despite this population being very heterogeneous and limited data available on cardiovascular risk. To assess cardiovascular risk in the overall population with LDL-C ≥4.9 mmol/L vs. <4.9 mmol/L and different subgroups.Methods: We analysed 5249 adults without atherosclerotic cardiovascular disease (ASCVD) and without LLT at baseline from CoLaus|PsyCoLaus, a prospective population-based cohort. ASCVD was our outcome.Results: Among 5249 participants (mean [SD] age 51.7 [10.5] years, 55% female, median follow-up 14.3 years), 291 (5.5%) had LDL-C ≥4.9 mmol/L. Overall, 300 (3.7%) participants experienced a first-time ASCVD, among which 27 (9%) had LDL-C ≥4.9 mmol/L. The adjusted hazard ratio (CI) for first-time ASCVD was 1.64 (1.10-2.44) for LDL-C ≥4.9 mmol/L vs. <4.9 mmol/L, 1.43 (0.57-3.58) in participants without hypertension, diabetes, or smoking (N=2497), 1.43 (0.80-2.55) in participants without suspicion of familial hypercholesterolemia (N=5101), and 1.46 (0.93-2.27) following adjustment for a polygenic risk score (data available for N=3728).Conclusions: The study reports an association between LDL-C ≥4.9 mmol/L and ASCVD in a large cohort from Switzerland. However, we found heterogeneity in risk across different subgroups. Furthermore, polygenic risk for coronary artery disease seems to partly account for this association. While further studies are needed to assess the cardiovascular risk specifically in healthier subgroups, our results suggest, that a more precise risk assessment is needed for individuals with LDL-C ≥4.9 mmol/L.","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Features of T Wave Inversion and Diagnosis of Cardiomyopathy: Relevance for a Cardiac Screening Programme in Young Individuals. T波反转的特征和心肌病的诊断：与年轻人心脏筛查计划的相关性。

IF 8.4 2区医学

European journal of preventive cardiology Pub Date : 2025-04-30 DOI: 10.1093/eurjpc/zwaf275

Ali Alzarka, Daniel Abioye, Hamish Maclachlan, Raghav Bhatia, Michael Papadakis, Sanjay Sharma, Gherardo Finocchiaro

{"title":"Features of T Wave Inversion and Diagnosis of Cardiomyopathy: Relevance for a Cardiac Screening Programme in Young Individuals.","authors":"Ali Alzarka, Daniel Abioye, Hamish Maclachlan, Raghav Bhatia, Michael Papadakis, Sanjay Sharma, Gherardo Finocchiaro","doi":"10.1093/eurjpc/zwaf275","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf275","url":null,"abstract":"Aims: To determine the clinical significance of T wave depth and T wave/QRS voltage ratio in young individuals who exhibit TWI on ECG performed as part of cardiac screening.Methods: We analysed an electronic database of individuals aged 14-35 years who underwent voluntary cardiac screening between 2008 and 2013. The prevalence of TWI, the lead distribution, the T wave depth and the T wave/QRS voltage ratio were assessed. Follow-up information was available for all subjects, including data regarding diagnosis of cardiac disease and major cardiac events.Results: The cohort consisted of 5360 individuals and TWI was documented in 120 (2%) cases. After further investigations, a diagnosis of cardiomyopathy was made in 16 cases. Individuals who were eventually diagnosed with cardiomyopathy exhibited more frequently TWI in multiple territories than individuals who did not receive a diagnosis at follow-up. T waves were deeper (p=0.03) in the former compared to the latter, but no significant difference in T/QRS ratio was observed. The cut-off value of TWI depth that best differentiated between presence and absence of cardiomyopathy was 0.183 mV; ROC curve analysis showed an AUC of 0.767. During a mean follow-up of 8.1±1.2 years, no deaths were documented, but 3 of the 16 patients experienced a sudden cardiac arrest (all of them were diagnosed with arrhythmogenic cardiomyopathy).Conclusions: T wave inversion is a relatively common ECG finding in young apparently healthy individuals. The distribution on multiple lead territories and deeper T waves are early indicators of an underlying cardiomyopathy.","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ADHD seems to be associated with increased cardiovascular risk - now what? 多动症似乎与心血管风险增加有关——现在呢？

IF 8.4 2区医学

European journal of preventive cardiology Pub Date : 2025-04-30 DOI: 10.1093/eurjpc/zwaf276

Anders Holt, Morten Lamberts, Helene Gjervig Hansen

引用次数: 0

Childhood 25-OH-vitamin D Levels Predict Early Cardiovascular Outcomes in Adulthood: The Cardiovascular Risk in Young Finns Study. 儿童时期25- oh -维生素D水平预测成年期早期心血管结局：芬兰年轻人心血管风险研究

IF 8.4 2区医学

European journal of preventive cardiology Pub Date : 2025-04-29 DOI: 10.1093/eurjpc/zwaf271

Jussi Niemelä, Tomi T Laitinen, Joel Nuotio, Katja Pahkala, Suvi Rovio, Jorma Viikari, Mika Kähönen, Terho Lehtimäki, Britt-Marie Loo, Tomi P Laitinen, Eero Jokinen, Päivi Tossavainen, Costan G Magnussen, Markus Juonala, Olli Raitakari

引用次数: 0

Nocturnal hypoxemic burden is associated with incident major adverse cardiovascular events in patients with type 2 diabetes. 2型糖尿病患者夜间低氧血症负担与主要不良心血管事件的发生有关。

IF 8.4 2区医学

European journal of preventive cardiology Pub Date : 2025-04-28 DOI: 10.1093/eurjpc/zwaf259

Sarah Driendl, Mathias Baumert, Michael Arzt, Klaus J Stark, Jan Pec, Frederick Sinha, Lukasz Kmiec, Florian Zeman, Stefan Stadler

{"title":"Nocturnal hypoxemic burden is associated with incident major adverse cardiovascular events in patients with type 2 diabetes.","authors":"Sarah Driendl, Mathias Baumert, Michael Arzt, Klaus J Stark, Jan Pec, Frederick Sinha, Lukasz Kmiec, Florian Zeman, Stefan Stadler","doi":"10.1093/eurjpc/zwaf259","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf259","url":null,"abstract":"Aims: Type 2 diabetes (T2D) prevalence is globally increasing and associated with cardiovascular disease. Whether oximetry-derived nocturnal hypoxemic burden (NHB) parameters are associated with incident major adverse cardiovascular events (MACE) in a population with T2D is not known.Methods: Overnight oximetry data from patients enrolled in the DIACORE (DIAbetes COhoRtE) sleep-disordered breathing sub-study, a prospective German cohort study of patients with T2D, was analyzed. NHB as cumulative time spent below 90% oxygen saturation (T90) as well as its composition of T90 attributed to acute desaturations (T90desaturation) and non-specific drifts in oxygen saturation (T90non-specific) was assessed. MACE was defined as a composite outcome of myocardial infarction, stroke, and cardiovascular death. Cox hazard regression analyses adjusted for potential known risk factors for atherosclerosis were conducted.Results: The analysis population consisted of 1255 participants (41% female, mean age 67 years, mean diabetes duration 9.6 years). After a median follow-up of 6.5 years, a MACE occurred in 149 (12%) patients. T90, but not apnea-hypopnea index, was significantly associated with an increased risk of incident MACE by 48% independently of other known risk factors for atherosclerosis (Quartile 4 vs. Q1-3 adjusted HR 1.48, 95% CI [1.04; 2.12], p=0.032). In particular, T90non-specific contributed to the elevated risk for incident MACE (Q4 vs. Q1-3 adjusted HR 1.62, 95% CI [1.14-2.30], p=0.007).Conclusion: In the present study, NHB was associated with MACE in patients with T2D and can be easily measured using oximetry. Further investigations are warranted to establish T90 reduction as a clinically meaningful treatment target.","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144005091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisiting Postprandial Physiology: A Missed Opportunity in Hypertension Screening. 重新审视餐后生理学：高血压筛查的一个错过的机会。

IF 8.4 2区医学

European journal of preventive cardiology Pub Date : 2025-04-28 DOI: 10.1093/eurjpc/zwaf272

Atul Pathak, Jens Jordan

引用次数: 0

Risk calculator of multimorbid risk of rehospitalisation and death from heart failure - including the contribution of the gut microbiome. 心衰再住院和死亡多病风险的风险计算器——包括肠道微生物群的贡献。

IF 8.4 2区医学

European journal of preventive cardiology Pub Date : 2025-04-28 DOI: 10.1093/eurjpc/zwaf270

Muhammad Zubair Israr, Andrea Salzano, Hong Zhan, Adriaan A Voors, Leong L Ng, Toru Suzuki

{"title":"Risk calculator of multimorbid risk of rehospitalisation and death from heart failure - including the contribution of the gut microbiome.","authors":"Muhammad Zubair Israr, Andrea Salzano, Hong Zhan, Adriaan A Voors, Leong L Ng, Toru Suzuki","doi":"10.1093/eurjpc/zwaf270","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf270","url":null,"abstract":"Background: The elucidation of the contributory role of multimorbidity to heart failure (HF) including the gut-heart axis has added a new dimension to our understanding of HF pathophysiology which is not reflected in currently available risk scores. The present investigation aimed to develop and validate a novel risk score model of multimorbidity for HF risk stratification.Methods: A risk model was developed based on the contribution of markers associated with HF multimorbidities on outcomes of mortality and/or rehospitalization due to HF (death/HF) at one year. Two independent HF cohorts were combined and randomly split 70:30 using a split-sample validation approach for training and validation cohorts which were not significantly different for investigated variables. Backward logistic regression was used to develop the risk model with a further scoring system to create a simple risk calculator.Results: A final 11-variable risk model (age, previous HF hospitalization, NYHA group III/IV, NT-proBNP, diastolic blood pressure, loop diuretic use, beta-blocker non-use, creatinine, COPD, diabetes, and combined gut metabolites) showed a diagnostic performance of 0.71 in the training cohort (C-statistic validation cohort, 0.70, p<0.001). A risk score/calculator was further developed based on this model with categorization into three (low-, mid- and high-) and two (low- and high-) risk groups, with both approaches demonstrating increased incidence of death/HF in patients at the highest risk (p<0.001).Conclusion: A novel risk model and score were derived which showed the contribution of comorbidities including the added value of the gut-heart axis on risk stratification of HF patients on rehospitalization and death.","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0