European journal of preventive cardiology最新文献

{"title":"Defective biological activities of high-density lipoprotein identify patients at highest risk of recurrent cardiovascular event.","authors":"Johanne Silvain, Clément Materne, Michel Zeitouni, Niki Procopi, Paul Guedeney, Delphine Brugier, Sophie Galier, Marie Lhomme, Maharajah Ponnaiah, Isabelle Guillas, Pukar Kc, Veronica D Dahik, Eric Frisdal, Eric Vicaut, Philippe Lesnik, Ghilas Rahoual, Wilfried Le Goff, Gilles Montalescot, Mathieu Kerneis, Maryse Guerin","doi":"10.1093/eurjpc/zwae356","DOIUrl":"10.1093/eurjpc/zwae356","url":null,"abstract":"<p><strong>Aims: </strong>Low cholesterol efflux capacity (CEC) and elevated levels of interleukin-1ß (IL-1ß) are both associated with residual cardiovascular risk in patients with acute myocardial infarction (MI) and may be used as new biomarkers to identify patients at higher cardiovascular risk.</p><p><strong>Methods and results: </strong>We evaluated potential synergetic effect of CEC and IL-1ß on recurrent major adverse cardiovascular events (MACE) at 1 year in 2012 patients with acute ST-segment elevation MI who underwent primary percutaneous coronary intervention. In addition, we evaluated the contribution to residual risk of HDL biological functions from 20 patients of the two extreme subgroups, focusing on CEC and anti-inflammatory properties. Patients with MACE during the first year after the MI had significantly lower serum CEC as compared with those without recurrent events and higher level of IL-1ß, and both associations were confirmed after multivariate analysis. We found an inverse relationship between CEC and circulating levels of the inflammatory marker IL-1ß, defining a very high risk (low CEC/high IL-1ß) and a low risk (high CEC/low IL-1ß) group of patients. Patients combining low CEC/high IL-1ß exhibited the highest risk of recurrent MACE at 1 year showing an additive prognostic value of these biomarkers, regardless of all the other clinical or biological factors. In this very high-risk subgroup, patients exhibited reduced HDL efflux capacity and defective ABCA1 and SR-BI with enhanced pro-inflammatory activity as a potential explanation for our clinical findings.</p><p><strong>Conclusion: </strong>Impaired CEC and elevated IL-1β synergistically increase the residual cardiovascular risk in MI patients, which could be explained by reduced HDL efflux capacity and enhanced HDL pro-inflammatory activity.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"1273-1285"},"PeriodicalIF":7.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the mean: the prognostic value of lipid variability in atherosclerosis and mortality.","authors":"Angela Pirillo, Alberico L Catapano","doi":"10.1093/eurjpc/zwaf321","DOIUrl":"10.1093/eurjpc/zwaf321","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"1245-1246"},"PeriodicalIF":7.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Despite more aggressive lipid-lowering guidelines worldwide, the majority of high-risk patients remain undertreated.","authors":"Peter P Toth","doi":"10.1093/eurjpc/zwaf288","DOIUrl":"10.1093/eurjpc/zwaf288","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"1202-1203"},"PeriodicalIF":7.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143981477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between remnant cholesterol and the risk of cardiovascular-kidney-metabolic syndrome progression: insights from the China health and retirement longitudinal study.","authors":"Xiaoyu Ding, Juan Tian, Xiaona Chang, Jia Liu, Guang Wang","doi":"10.1093/eurjpc/zwaf248","DOIUrl":"10.1093/eurjpc/zwaf248","url":null,"abstract":"<p><strong>Aims: </strong>Advanced cardiovascular-kidney-metabolic (CKM) syndrome has profound impacts on adverse clinical outcomes, particularly cardiovascular disease (CVD). Remnant cholesterol (RC) has emerged as a potential risk factor for metabolic and cardiovascular disorders, but its association with CKM syndrome remains unexplored. This study aimed to investigate the relationship between RC and CKM syndrome progression.</p><p><strong>Methods and results: </strong>This study utilized data from the China Health and Retirement Longitudinal Study (CHARLS) spanning 2011-20. Logistic regression models were conducted to estimate the association between RC and advanced CKM stages at baseline. Cox regression models were employed to assess the association between baseline RC and incident CVD during follow-up. In the baseline analysis, individuals in higher RC quartiles (Q2-Q4) had a significantly increased risk of advanced CKM stages compared to the lowest RC quartile (Q1) (P for trend <0.001). During the median follow-up period of 9.0 years, 1498 participants (21.8%) across CKM Stages 0-3 developed CVD. After multivariable adjustment, per 1-SD increase in RC was associated with a higher risk of CVD. Similarly, in quartile analyses, the risk of CVD remained elevated in the Q3 [hazard ratio (HR) 1.181, 95% confidence interval (CI) 1.021-1.366] and Q4 (HR 1.195, 95% CI 1.032-1.383) groups compared to the first RC quartile group.</p><p><strong>Conclusion: </strong>Elevated RC was independently associated with advanced CKM stages. Furthermore, among individuals with CKM syndrome without baseline CVD, elevated RC emerged as a significant risk factor for incident CVD. Early detection and management of RC may provide clinical benefits for preventing CKM progression.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"1157-1165"},"PeriodicalIF":7.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A LDL-cholesterol level above 3 mmol/L should be treated: a personal case report.","authors":"Gisle Langslet","doi":"10.1093/eurjpc/zwaf158","DOIUrl":"10.1093/eurjpc/zwaf158","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"1291-1292"},"PeriodicalIF":7.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of very-high high-density lipoprotein cholesterol and association with incident atherosclerotic cardiovascular disease and all-cause mortality.","authors":"Bharat Rawlley, Kartik Gupta, Pratyaksh P Vaishnav, Sachin S Parikh, Salim S Virani, Srikanth Yandrapalli, Andrew Weinberg, Debanik Chaudhuri","doi":"10.1093/eurjpc/zwaf297","DOIUrl":"10.1093/eurjpc/zwaf297","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"1288-1290"},"PeriodicalIF":7.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bridging the cost-effectiveness gap in cardiovascular disease prevention for statin-intolerant patients.","authors":"Jerrin S Philip, Christie M Ballantyne","doi":"10.1093/eurjpc/zwaf295","DOIUrl":"10.1093/eurjpc/zwaf295","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"1271-1272"},"PeriodicalIF":7.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fit but not immune from the risk: the hidden burden of dyslipidemia in elite athletes.","authors":"Mihail Celeski, Pietro Lavisci, Enrico Bernardo Loddo, Camilla Calandri, Jacopo Kowalczyk, Armando Ferrera, Simone Crotta, Marcello Rizzi, Barbara Sposato, Maurizio Volterrani, Lorenzo Buzzelli, Raffaella Mistrulli, Pietro Jansiti, Virginia Desiderio, Maria Rosaria Squeo, Giuseppe Di Gioia","doi":"10.1093/eurjpc/zwaf607","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf607","url":null,"abstract":"<p><p>Elite athletes are widely perceived to possess exceptional cardiovascular health due to their high levels of physical activity. However, emerging evidence suggests that among the established cardiovascular risk factors, dyslipidemia remains prevalent and frequently under-recognized in this population. Despite their athletic status, elite competitors, including Olympic and Paralympic athletes, may exhibit lipid abnormalities influenced by a complex interplay of factors such as sport type, training intensity, gender, ethnicity and disability status. This review aims to provide a comprehensive overview of dyslipidemia in elite athletes, exploring its prevalence, contributing physiological and lifestyle factors, clinical consequences and current approaches to assessment and management. Special attention is given to population-specific considerations, including gender, sport type and ethnicity. The limitations of general population cardiovascular risk scores in this context are discussed, with a focus on the need for athlete-specific tools such as the proposed \"Lipid Athlete Score.\" Management strategies, ranging from lifestyle modification to the cautious use of pharmacologic agents and emerging nutraceutical interventions, are critically evaluated. Finally, the review highlights gaps in current research and outlines future directions, emphasizing the importance of tailored, evidence-based approaches to preserve cardiovascular health and athletic longevity in this unique population.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remnant cholesterol: a crucial risk modifier with a significant predictive value in elderly.","authors":"Kapka Miteva, François Mach","doi":"10.1093/eurjpc/zwaf044","DOIUrl":"10.1093/eurjpc/zwaf044","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"1178-1180"},"PeriodicalIF":7.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remnant cholesterol for cardiovascular risk assessment in the young: ready for prime time?","authors":"Konstantinos C Koskinas","doi":"10.1093/eurjpc/zwaf097","DOIUrl":"10.1093/eurjpc/zwaf097","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"1190-1191"},"PeriodicalIF":7.5,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143467445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}