European journal of preventive cardiology最新文献

{"title":"Inflammation in the Spotlight: Neutrophil-to-Lymphocyte Ratio Takes Centre Stage in Atherosclerotic Cardiovascular Disease.","authors":"Angelo Laino, Antonio Pio Vitale, Raffaele Piccolo","doi":"10.1093/eurjpc/zwaf606","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf606","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated with Elevated High-Sensitivity C-Reactive Protein Levels in Individuals with Atherosclerotic Cardiovascular Disease in the US and the UK.","authors":"Kausik K Ray, Simon Bertram Reuter, Aysegul Dalbeler, Mads D Faurby, Gasper Letnar, Jimmi Mathisen, Michael G Nanna, Fu Siong Ng, Jonathan Pearson-Stuttard, Naveed Sattar, Andrew Thompson, Ann Marie Navar","doi":"10.1093/eurjpc/zwaf609","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf609","url":null,"abstract":"<p><strong>Aim: </strong>Novel therapies are under evaluation for upstream inhibition of inflammatory pathways in atherosclerotic cardiovascular disease (ASCVD). Elevated high-sensitivity C-reactive protein (hsCRP) is a downstream marker of these pathways but is not routinely measured. We aimed to identify potential factors associated with elevated hsCRP.</p><p><strong>Methods: </strong>This cross-sectional study included individuals with ASCVD from the UK Biobank (2006-2010) and the US National Health and Nutrition Examination Survey (NHANES; 1999-2010 and 2015-2018). Factors associated with elevated hsCRP (2-10 mg/L) were evaluated using multivariable logistic regression.</p><p><strong>Results: </strong>Six factors were associated with greater odds of elevated hsCRP in both cohorts (UK Biobank n = 23,045; NHANES n = 3,415): obesity (UK Biobank odds ratio [OR] [95% confidence interval (CI)]: 3.48 [3.18-3.80]); NHANES 4.11 [2.66-6.34]), overweight (1.56 [1.44-1.70]; 2.26 [1.51-3.38]), being a current smoker (2.47 [2.27-2.69]; 1.96 [1.23-3.10]), female sex (1.69 [1.59-1.80]; 1.69 [1.24-2.31]), and increased low-density lipoprotein cholesterol (1.05 [1.04-1.06]; 1.00 [1.00-1.00], per 10 mg/dL increase) and triglyceride levels (1.01 [1.01-1.01]; 1.00 [1.00-1.00], per 10 mg/dL increase) (all p <0.05). Receiving statins was associated with lower odds in both cohorts (UK Biobank OR [95% CI] 0.69 [0.64-0.75]; NHANES 0.54 [0.39-0.74]). When these factors, plus chronic kidney disease stage G3-5, were considered in combination, hsCRP levels were higher in individuals with more factors (median hsCRP with seven factors: UK Biobank 5.39 mg/L; NHANES 6.99 mg/L).</p><p><strong>Conclusions: </strong>The factors identified may support data-driven targeted testing to identify those most likely to have elevated hsCRP, who could potentially benefit from emerging anti-inflammatory therapies.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Sugar to Calcification: Unveiling Hyperglycemia's Valvular Risk.","authors":"Nicholas Koran, Khalil Anchouche, James C Engert","doi":"10.1093/eurjpc/zwaf621","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf621","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Structured Exercise Training on Chronotropic Incompetence in Patients with Heart Failure with preserved Ejection Fraction.","authors":"Riwa Nasser, Faro R Verelst, Stephan Mueller, Ephraim B Winzer, Paul J Beckers, Caroline M Van De Heyning, Ulrik Wisløff, Burkert Pieske, Volker Adams, Martin Halle, Emeline M Van Craenenbroeck, Andreas B Gevaert","doi":"10.1093/eurjpc/zwaf628","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf628","url":null,"abstract":"<p><strong>Background and aims: </strong>Chronotropic incompetence (CI) is common in heart failure with preserved ejection fraction (HFpEF) and contributes to reduced exercise tolerance. However, the effects of exercise training on CI in HFpEF remain unknown. We aimed to assess the effect of different exercise training intensities on chronotropic reserve in HFpEF.</p><p><strong>Methods: </strong>This is a subanalysis of the OptimEx-Clin trial. Patients with HFpEF were randomized to high-intensity interval training (HIIT), moderate continuous training (MCT) or guideline control (GC). CI was assessed during cardiopulmonary exercise testing at baseline and 3 months. CI was defined as a chronotropic index ≤0.62 in patients on negative chronotropic medications and ≤0.80 in others.</p><p><strong>Results: </strong>Among 175 patients with HFpEF (66% female, mean age 70±8 years), 144 completed follow-up. CI was present in 51% and was associated with lower peak oxygen uptake (16.5±4.2 vs. 21.1±5.2 mL/kg/min, p<.001), lower peak workload (89±28 vs. 116±39 W, p<.001), and poorer ventilatory efficiency (35.2±7.1 vs. 32.6±6.8, p=.014) at baseline. HIIT and MCT did not improve chronotropic index, %predicted peak heart rate, nor CI prevalence after 3 months (all p>.500), and adjusting for negative chronotropic drug use did not change results. Nevertheless, HIIT and MCT improved V̇O2peak and workload (p<.001) versus GC, regardless of the presence of CI.</p><p><strong>Conclusion: </strong>In elderly patients with HFpEF, neither HIIT nor MCT during 3 months significantly improved chronotropic reserve or reduced CI prevalence, but exercise capacity was improved.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketone Therapy Prevents Semaglutide-induced Loss of Cardiac Mass.","authors":"Mya A Schmidt, Yasser Abuetabh, Masaaki Naganuma, Ramana Vaka, Matthieu C P Zolondek, Jody L Levasseur, Daniela Y Morales-Llamas, Mahmoud A El-Ghiaty, Shelly Braun, Darius Sahid, Laibah Khan, Ethan Kwan, Danica K Roth, Mourad Ferdaoussi, Richard Fahlman, Jason R B Dyck","doi":"10.1093/eurjpc/zwaf605","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf605","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting cardiovascular events in allogeneic hematopoietic stem cell transplant recipients.","authors":"Benjamin Sibilia, Trecy Gonçalves, Florian Chevillon, Lin Pierre Zhao, Michael Benayoun, Mathilde Baudet, Solenn Toupin, Nathalie Dhedin, Nicolas Boissel, Manveer Singh, Alexandre Unger, Flore Sicre de Fontbrune, David Michonneau, Aliénor Xhaard, Régis Peffault de Latour, Damien Logeart, Alain Cohen Solal, Fériel Azibani, Jean-Guillaume Dillinger, Patrick Henry, Marie Robin, Théo Pezel","doi":"10.1093/eurjpc/zwaf593","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf593","url":null,"abstract":"<p><strong>Aims: </strong>Patients undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT) are at increased risk of cardiovascular complications; however, comprehensive data on these risks in large cohorts remain limited. This study aims to identify predictors of cardiovascular events in a large cohort of alloHSCT patients.</p><p><strong>Methods: </strong>We conducted a retrospective monocentric study including all consecutive patients aged 15 years and older with haematological malignancies who underwent alloHSCT between 2011 and 2020. Data were extracted from electronic medical records, including demographic, clinical, and transplant-specific variables. The primary composite outcome was cardiotoxicity including cardiovascular death, heart failure (HF), rhythm/conduction disorders, acute arterial events, venous thromboembolism (VTE), and myopericarditis. Predictors of cardiotoxicity were analysed using Cox proportional hazards regression and Fine-and-Gray models.</p><p><strong>Results: </strong>Among 1,027 patients recruited (age 45±16 years, 62% male), 30% experienced cardiotoxicity after a median (interquartile range, IQR) follow-up of 4 (1-7) years. The median (IQR) time to the first event was 8 months (3-17). In multivariable analysis, independent predictors for early events (≤100 days) were age, hypertension, history of HF, cancer therapy-related cardiac dysfunction (CTRCD), and high-dose administration of cyclophosphamide (≥100 mg/kg). For late events (>100 days), independent predictors were age, hypertension, history of VTE, atrial fibrillation/flutter, history of HF, CTRCD, previous liposomal anthracycline exposure, and high-risk hematopoietic cell transplantation-comorbidity index(HCT-CI) score category.</p><p><strong>Conclusion: </strong>Our study identifies independent predictors of early and late cardiotoxicity, including demographic data, cardiovascular risk factors, history of cardiovascular disease and oncologic history.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualising SGLT2 inhibitors Cardiovascular Benefit in Patients with Type 2 Diabetes: Target Trial Emulation Meets Machine Learning.","authors":"Yosef Manla, Wael Almahmeed, Francesco Cosentino","doi":"10.1093/eurjpc/zwaf625","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf625","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Framingham risk score associates with incident cancer and heart failure.","authors":"Pieter F van den Berg, Laura I Yousif, Yvonne Koop, Ezgi Hatip Ünlü, Melis Asik, Bart J van Essen, Kevin Damman, Adriaan A Voors, Nabil Sayour, Thomas F Kok, Yiqian Yang, Isabella Kardys, Stephan J L Bakker, Bert van der Vegt, Navin Suthahar, Rudolf A de Boer, Wouter C Meijers","doi":"10.1093/eurjpc/zwaf618","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf618","url":null,"abstract":"<p><strong>Aims: </strong>The Framingham Risk Score (FRS), a tool primarily used for atherosclerotic cardiovascular disease (ASCVD) risk stratification, incorporates factors like age, obesity, and smoking. However, its role in predicting cancer and heart failure (HF) risk remains unclear, while emerging data suggest these two conditions coincide frequently.</p><p><strong>Methods: </strong>We conducted a post-hoc analysis using data from the PREVEND study and validated our findings in the UK Biobank. We examined the association between FRS tertiles at baseline and incident cancer or HF. Fine-Gray regression models were used to calculate subdistribution hazard ratios (sHRs), adjusting for estimated glomerular filtration rate and urinary albumin excretion with all-cause mortality as a competing risk.</p><p><strong>Results: </strong>In PREVEND, we included 8123 participants (mean age 49±13 years, 50% female). Over follow-up periods of 17.46 years (IQR 17.15-17.80) years (cancer) and 23.39 years (IQR 13.78-23.81) years (HF), 1176 participants developed new-onset cancer, and 758 developed new-onset HF. In a multivariable analysis, participants in the highest FRS tertile compared to the lowest had a higher hazard for both cancer (sHR 2.32, p<0.001) and HF (sHR 10.08, p<0.001). Participants in the highest FRS tertile had the worst survival (log-rank p<0.001). We validated these findings in the UK Biobank (N=389942) wherein individuals in the highest FRS tertile also had a higher hazard for both cancer (sHR 2.05, p<0.001) and HF (sHR 5.99, p<0.001) compared to the lowest tertile.</p><p><strong>Conclusion: </strong>The FRS associates with new-onset cancer or HF, implicating a broader clinical application of the FRS beyond ASCVD-risk stratification in cardio-oncology.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"One-year treatment trajectories of patients with statin intolerance: results from a multicentre registry.","authors":"Paulina E Stürzebecher, Tobias Schneider, Ioanna Gouni-Berthold, Ole Frenzel, Oliver Weingärtner, Ursula Kassner, Ulrike Schatz, Ulrich Laufs, Julius L Katzmann","doi":"10.1093/eurjpc/zwaf619","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf619","url":null,"abstract":"<p><strong>Aims: </strong>Statin intolerance (SI) is a common phenomenon that has been associated with increased cardiovascular risk. Prospective data on the treatment course of patients with SI are scarce.</p><p><strong>Methods: </strong>In the observational, prospective, multicentre statin intolerance registry, 1,111 patients with SI, defined as intolerance to at least two different statins, were recruited between 2021 and 2023 in Germany. We report results of the one-year follow-up, stratified by persisting pain (self-report of at least moderate symptoms in the EQ-5D-5L dimension of pain/discomfort at baseline and follow-up) and by patient characteristics.</p><p><strong>Results: </strong>Data of 1,032 patients were available at one-year follow-up, of which 39.1% reported persisting, 34.2% no, 11.9% new, and 14.8% resolved pain. Patients with persisting pain were more often female, older, had more co-morbidities, lower quality of life, and more often discontinued lipid-lowering therapy (LLT). During follow-up, 43.2% of patients had an escalation of LLT, 17.0% de-escalation, and 39.8% no change. This resulted in LDL cholesterol (LDL-C) reductions from median (IQR) 2.3 (1.6-3.6) mmol/L at baseline to 2.0 (1.4-2.8) mmol/L after one year, while LDL-C target attainment improved from 18.0 to 24.0%. Women had more often de-escalation of LLT and a significantly smaller improvement in LDL-C target attainment than men.</p><p><strong>Conclusion: </strong>While LDL-C values improved during follow-up, three in four statin-intolerant patients still did not achieve their LDL-C targets and many patients reported persisting pain, especially women. Our results provide a rationale for tailored approaches to improve care in these patients.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular Disease in Women: do we focus on single jigsaw pieces or look at the whole puzzle?","authors":"S Krasner, M Li, P Leeson","doi":"10.1093/eurjpc/zwaf620","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf620","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}