Min-Kuang Tsai, Jackson Pui Man Wai, Chih-Cheng Hsu, Mei-Yi Wu, Chi-Pang Wen
{"title":"Letter to the editor.","authors":"Min-Kuang Tsai, Jackson Pui Man Wai, Chih-Cheng Hsu, Mei-Yi Wu, Chi-Pang Wen","doi":"10.1093/eurjpc/zwae227","DOIUrl":"10.1093/eurjpc/zwae227","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"616-617"},"PeriodicalIF":8.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prolactin levels and cardiovascular disease: a complicate relationship or a confounding association?","authors":"Andreas S Papazoglou, Ana Rita Leite","doi":"10.1093/eurjpc/zwad176","DOIUrl":"10.1093/eurjpc/zwad176","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"612-615"},"PeriodicalIF":8.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9489267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Valves from Venus, valves from Mars?","authors":"Anne Bernard, Victor Aboyans","doi":"10.1093/eurjpc/zwaf294","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf294","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The future of cardiovascular disease: game over or game on?","authors":"Jean Ferrières","doi":"10.1093/eurjpc/zwaf025","DOIUrl":"10.1093/eurjpc/zwaf025","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"553-554"},"PeriodicalIF":8.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Oral Formulation and SGLT2i Interaction: Key Nuances in Semaglutide's Effect on Atrial Fibrillation.","authors":"Ahmed Shamsulddin","doi":"10.1093/eurjpc/zwaf280","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf280","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143960199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Promise and Pitfalls of Psychosocial Data in Cardiovascular Prevention.","authors":"Taha Bhatti","doi":"10.1093/eurjpc/zwaf281","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf281","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Florian Mourre, Roch Giorgi, Lauranne Cattieuw, Antonio Gallo, Philippe Moulin, Sybil Charrière, Karine Aouchiche, Vincent Rigalleau, François Schiele, Ariane Sultan, Patrick Tounian, René Valéro, Sophie Béliard
{"title":"Cascade screening in familial hypercholesterolaemia is associated with earlier statin initiation and fewer cardiovascular events than opportunistic screening.","authors":"Florian Mourre, Roch Giorgi, Lauranne Cattieuw, Antonio Gallo, Philippe Moulin, Sybil Charrière, Karine Aouchiche, Vincent Rigalleau, François Schiele, Ariane Sultan, Patrick Tounian, René Valéro, Sophie Béliard","doi":"10.1093/eurjpc/zwaf234","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf234","url":null,"abstract":"<p><strong>Aims: </strong>The aim of this study is to assess whether the family cascade screening strategy for identifying patients with heterozygous familial hypercholesterolaemia (HeFH) is associated with a reduction in cardiovascular events compared with opportunistic screening strategies.</p><p><strong>Methods and results: </strong>We retrospectively included 3232 patients, from the French FH registry, REFERCHOL, with a molecular diagnosis. We compared patients according to their screening strategy for HeFH: index cases (opportunistic screening) and cascade screening cases (patients diagnosed by cascade screening) on clinical and biological characteristics. We first compared patients according to screening modality using χ² and Student's t-tests and performed multivariate logistic regression to assess the association between screening strategy and the risk of cardiovascular events. We finally performed the same tests in an age- and sex-matched subpopulation. Compared with index cases (2106 patients), cascade screening cases (1126 patients) started statin use 14 years earlier [18.1 (interquartile range 12.5-29.1) years vs. 31.8 (19.7-42.4) years, P < 0.001] and 8.3% had a cardiovascular event prior to the first visit, vs. 26.5% in the index cases group (P < 0.001). In multivariate logistic regression, the cascade screening was independently associated with 51% less atherosclerotic cardiovascular disease (ASCVD) than the opportunistic screening. Age at statin initiation was also associated with ASCVD, with a higher adjusted odd ratio for higher age categories. In an age- and sex-matched analysis, cascade screening was no longer associated with ASCVD, but age at statin initiation remained.</p><p><strong>Conclusion: </strong>The cascade screening strategy for familial hypercholesterolaemia is associated with 51% fewer cardiovascular events in genetically confirmed heFH probably due to an earlier age at treatment initiation.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association of Cardiovascular-Kidney-Metabolic Overlap with Physical Function and Prognosis in Older Patients with Heart Failure: A Post-hoc Analysis of the FRAGILE-HF and SONIC-HF.","authors":"Taisuke Nakade, Yuya Matsue, Yoshiaki Ikeda, Daichi Maeda, Nobuyuki Kagiyama, Yudai Fujimoto, Hanako Inoue, Tsutomu Sunayama, Taishi Dotare, Kentaro Jujo, Kazuya Saito, Kentaro Kamiya, Hiroshi Saito, Yuki Ogasahara, Emi Maekawa, Masaaki Konishi, Takeshi Kitai, Kentaro Iwata, Hiroshi Wada, Takatoshi Kasai, Hirofumi Nagamatsu, Misako Toki, Kenji Yoshioka, Shin-Ichi Momomura, Tohru Minamino","doi":"10.1093/eurjpc/zwaf279","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf279","url":null,"abstract":"<p><strong>Aims: </strong>The prevalence and impact of cardiovascular, kidney, and metabolic (CKM) overlap on physical function and prognosis in older patients with heart failure (HF) remain unclear. This study aimed to assess the impact of overlapping CKM conditions on physical function and prognosis in older patients with HF.</p><p><strong>Methods: </strong>This post-hoc analysis of the FRAGILE-HF (main cohort) and SONIC-HF (validation cohort), both prospective multicentre studies, included patients aged ≥65 years who were hospitalised for HF. CKM overlap was defined as the presence of one or more of the following comorbidities: atherosclerotic cardiovascular disease, chronic kidney disease, or type 2 diabetes mellitus. The primary outcome was a composite of all-cause death and HF readmission within 2 years. Physical function was assessed using gait speed, five-time chair stand test (5CST), short physical performance battery (SPPB), and 6-min walk test (6MWT). To validate the prognostic association of CKM overlap, we conducted an external validation using the SONIC-HF cohort, an independent prospective study with identical inclusion criteria.</p><p><strong>Results: </strong>Of 1,113 patients (mean age: 80±8 years, 58.1% male), 193 (17.3%) had no CKM conditions, 370 (33.2%) had one, and 550 (49.5%) had two or three. A multivariable logistic regression model, adjusted for age, sex, comorbidities, and New York Heart Association functional class, showed that two or three CKM conditions were independently associated with lower physical function (5CST: odds ratio [OR]=1.91, P<0.001; SPPB: OR=1.87, P=0.001; 6MWT: OR=1.84, P=0.003). Kaplan-Meier analysis demonstrated a significant stepwise association between CKM overlap and the primary outcome in both the FRAGILE-HF and SONIC-HF cohorts (Log-rank: P < 0.001). Adjusted Cox analysis demonstrated that the overlapping CKM conditions were associated with the primary outcome, with two or more CKM conditions showing a statistically significant association in the FRAGILE-HF cohort (HR = 1.64, P = 0.003). Similarly, although statistical significance was not reached in the SONIC-HF cohort, a stepwise increase in HR was observed (2-3 CKM conditions: HR = 1.90, 95% CI: 0.97-3.73, P = 0.063).</p><p><strong>Conclusion: </strong>Older patients with HF who have greater CKM overlap exhibited significantly poorer physical function and prognosis.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}