European journal of preventive cardiology最新文献

{"title":"Visceral adiposity by CT imaging and cardiovascular risk: Seeing is believing.","authors":"Konstantinos C Koskinas","doi":"10.1093/eurjpc/zwaf149","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf149","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SGLT2 Inhibitors in Cancer Patients: A Paradigm Shift in Cardio-Oncology?","authors":"Jennifer Cautela, Joachim Alexandre","doi":"10.1093/eurjpc/zwaf146","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf146","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular benefit of statin use against air pollutant exposure in older adults.","authors":"Kyuwoong Kim, Seogsong Jeong, Seulggie Choi, Jooyoung Chang, Daein Choi, Gyeongsil Lee, Seong Rae Kim, Sang Min Park","doi":"10.1093/eurjpc/zwae061","DOIUrl":"10.1093/eurjpc/zwae061","url":null,"abstract":"<p><strong>Aims: </strong>Little is known about the cardiovascular benefit of statin use against ambient air pollution among older adults who are at higher risk of cardiovascular disease (CVD) potentially owing to age-related declines in cardiovascular functions along with other risk factors.</p><p><strong>Methods and results: </strong>This retrospective, population-based cohort study consisted of adults aged 60 years and older free of CVD at baseline identified from the National Health Insurance Service database linked to the National Ambient Air Monitoring Information System for average daily exposure to PM10 and PM2.5 in 2015 in the major metropolitan areas in the Republic of Korea. The follow-up period began on 1 January 2016 and lasted until 31 December 2021. The Cox proportional hazards model was used to evaluate the association of cardiovascular benefit with statin use against different levels of air pollutant exposure. Of 1 229 444 participants aged 60 years and older (mean age, 67.4; 37.7% male), 377 076 (30.7%) were identified as statin users. During 11 963 322 person-years (PYs) of follow-up, a total of 86 018 incident stroke events occurred (719.0 events per 100 000 PYs). Compared to statin non-users exposed to high levels of PM10 (>50 µg/m3) and PM2.5 (>25 µg/m3), statin users had 20% [adjusted hazard ratio (HR), 0.80; 95% confidence intervals (CI), 0.75-0.85] and 17% (adjusted HR, 0.80; 95% CI, 0.80-0.86) lower adjusted risk of incident stroke for PM10 and PM2.5, respectively. A similar risk reduction for incident CVD was also found among statin users exposed to low or moderate levels of PM10 (≤50 µg/m3) and PM2.5 (≤25 µg/m3) exposure.</p><p><strong>Conclusion: </strong>Among adults aged 60 years and older with high and low or moderate levels of exposure to PM10 and PM2.5, statin use was associated with a significantly lower risk of stroke.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"288-298"},"PeriodicalIF":8.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139746445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of SGLT2i on kidney outcomes of individuals with type2 diabetes according to blood pressure levels.","authors":"Takahiro Jimba, Hidehiro Kaneko, Yuta Suzuki, Akira Okada, Tatsuhiko Azegami, Toshiyuki Ko, Katsuhito Fujiu, Hiroyuki Morita, Norifumi Takeda, Kaori Hayashi, Takashi Yokoo, Koichi Node, Issei Komuro, Hideo Yasunaga, Masaomi Nangaku, Norihiko Takeda","doi":"10.1093/eurjpc/zwaf156","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf156","url":null,"abstract":"<p><strong>Aims: </strong>Sodium-glucose cotransporter-2 (SGLT2) inhibitors have proven kidney protective effects. Given that the SGLT2 inhibitors lower blood pressure (BP), the magnitude of their kidney benefits may vary depending on an individual's BP. Therefore, we investigated whether baseline BP modifies the effect of SGLT2 inhibitors on kidney function.</p><p><strong>Methods: </strong>This study included individuals with SGLT2 inhibitors or dipeptidyl peptidase-4 (DPP4) inhibitors newly prescribed for type 2 diabetes using a nationwide epidemiological cohort and performed propensity score matching (1:2). The primary outcome was the annual eGFR decline. We further investigated the interaction effect of systolic BP (sBP) at the time of prescription using a 3-knot restricted cubic spline model.</p><p><strong>Results: </strong>We analyzed 2,148 individuals with SGLT2 inhibitor prescriptions and 4,296 matched individuals with DPP4 inhibitor prescriptions. Overall, the annual eGFR decline was less pronounced in the SGLT2 inhibitor group than in the DPP4 inhibitor group (-1.32 ml/min/1.73 m2 vs -1.50 ml/min/1.73 m2). The treatment effect of SGLT2 inhibitors over DPP4 inhibitors was augmented with higher sBP (p for interaction = 0.0199). Further, after adjusting the definition of outcomes to a 30% or 40% reduction in eGFR, the advantages of SGLT2 inhibitors persisted, with a trend of augmented effect with higher sBP. Notably, annual eGFR decline was exacerbated for females presented with lower sBP when treated with SGLT2 inhibitors compared to DPP4 inhibitors.</p><p><strong>Conclusions: </strong>This nationwide cohort analysis demonstrated that the kidney protective effect of SGLT2 inhibitors could be modified by baseline sBP, highlighting the importance of patient selection by assessing their BP.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rural-urban disparities in mortality of patients with acute myocardial infarction and heart failure: a systematic review and meta-analysis.","authors":"Babar Faridi, Steven Davies, Rashmi Narendrula, Allan Middleton, Rony Atoui, Sarah McIsaac, Sami Alnasser, Renato D Lopes, Mark Henderson, Jeff S Healey, Dennis T Ko, Mohammed Shurrab","doi":"10.1093/eurjpc/zwae351","DOIUrl":"10.1093/eurjpc/zwae351","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Aims: &lt;/strong&gt;Patients with cardiac disease living in rural areas may face significant challenges in accessing care, and studies suggest that living in rural areas may be associated with worse outcomes. However, it is unclear whether rural-urban disparities have an impact on mortality in patients presenting with acute myocardial infarction (AMI) and heart failure (HF). This meta-analysis aimed to assess differences in mortality between rural and urban patients presenting with AMI and HF.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods and results: &lt;/strong&gt;A systematic search of the literature was performed using PubMed, Embase, MEDLINE, and CENTRAL for all studies published until 16 January 2024. A grey literature search was also performed using a manual web search. The following inclusion criteria were applied: (i) studies must compare rural patients to urban patients presenting to hospital with AMI or HF, and (ii) studies must report on mortality. The primary outcome was all-cause mortality. Comprehensive data were extracted including study design, patient characteristics (sex, age, and comorbidities), sample size, follow-up period, and outcomes. Odds ratios (ORs) were pooled with fixed-effects model. A subgroup analysis was performed to investigate causes for heterogeneity in which studies were separated based on in-hospital mortality, post-discharge mortality, and region of origin including North America, Europe, Asia, and Australia. In total, 37 studies were included (29 retrospective studies, 4 cross-sectional studies, and 4 prospective cohort studies) in our meta-analysis: 24 studies for AMI, 11 studies for HF, and 2 studies for both AMI and HF. This included a total of 21 107 886 patients with AMI (2 230 264 of which were in rural regions) and 18 434 270 patients with HF (2 655 469 of which were in rural regions). Rural patients with AMI had similar age (mean age 69.8 ± 5.7; vs. 67.5 ± 5.1) and were more likely to be female (43.2% vs. 38.5%) compared to urban patients. Rural patients with HF had similar age (mean age 77.1 ± 4.4 vs. 76.5 ± 4.2) and were more likely to be female (56.4% vs. 49.5%) compared to urban patients. The range of follow-up for the AMI cohort was 0 days to 24 months, and the range of follow-up for the HF cohort was 0 days to 24 months. Compared with urban patients, rural patients with AMI had higher mortality rate at follow-up [15.5% vs. 13.4%; OR 1.18, 95% confidence interval (CI), 1.13-1.24; I2 = 97%]. Compared with urban patients, rural patients with HF had higher mortality rate at follow-up (12.3% vs. 11.6%; OR 1.11, 95% CI, 1.11-1.12; I2 = 98%).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;To our knowledge, this is the first systematic review and meta-analysis assessing mortality differences between rural and urban patients presenting with AMI and HF. We found that patients living in rural areas had an increased risk of mortality when compared to patients in urban areas. Clinical and policy efforts are required to reduce these disparit","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"327-335"},"PeriodicalIF":8.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between exposure to air pollution and increased ischaemic stroke incidence: a retrospective population-based cohort study (EP-PARTICLES study).","authors":"Michał Święczkowski, Gregory Y H Lip, Anna Kurasz, Emil J Dąbrowski, Anna Tomaszuk-Kazberuk, Jacek W Kamiński, Joanna Strużewska, Sławomir Dobrzycki, Łukasz Kuźma","doi":"10.1093/eurjpc/zwae301","DOIUrl":"10.1093/eurjpc/zwae301","url":null,"abstract":"<p><strong>Aims: </strong>Short-term effects of Polish smog, particularly benzo(alpha)pyrene [B(a)P], are unclear. We aimed to examine the association between short-term exposure to air pollution and ischaemic stroke (IS) incidence.</p><p><strong>Methods and results: </strong>We conducted a retrospective population-based cohort study including an EP-PARTICLES cohort of 8 million inhabitants in the years 2011-20 (80 million person-years of observation). Individual clinical data on emergency hospitalizations due to IS (ICD-10: I63.X) was analysed. We used quasi-Poisson models to examine municipality-specific associations between air pollutants and IS, considering various covariates. We recorded 146 262 cases of IS with a dominance of females (51.8%) and people over 65 years old (77.6%). In the overall population, exposure to PM2.5, NO2, B(a)P, and SO2 increased the risk of IS onset on the day of exposure by 2.4, 1, 0.8, and 0.6%, respectively. Age and sex were modifying variables for PM2.5, NO2, and B(a)P exposure with more pronounced effects in non-elderly individuals and women (all Pinteraction < 0.001). Residents of regions with high tobacco and alcohol consumption were more sensitive to the effects of PM2.5 and SO2. The slopes of response-effect curves were non-linear and steeper at lower concentrations.</p><p><strong>Conclusion: </strong>Exposure to air pollution may be associated with higher IS incidence, particularly posing a higher risk to non-elderly women. Harmful lifestyle habits might exacerbate its impact. Exposure to even low levels of air pollutants had negative effects.</p><p><strong>Registration: </strong>The study was registered at ClinicalTrials.gov (NCT05198492).</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"276-287"},"PeriodicalIF":8.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142282575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nationwide analysis of the relationship between low ambient temperature and acute aortic dissection-related hospitalizations.","authors":"Katsuhito Kato, Takuya Nishino, Toshiaki Otsuka, Yoshihiko Seino, Tomoyuki Kawada","doi":"10.1093/eurjpc/zwae278","DOIUrl":"10.1093/eurjpc/zwae278","url":null,"abstract":"<p><strong>Aims: </strong>Acute aortic dissection (AAD) is a life-threatening cardiovascular emergency. Therefore, identifying modifiable risk factors for AAD is of great public health significance. An association between ambient temperature (AT) and AAD has been reported; however, not all findings have been elucidated. This study examined the association between AAD-related hospitalization and AT using data from the Japanese Registry of All Cardiac and Vascular Diseases Diagnostic Procedure Combination (JROAD-DPC), which is a nationwide claims-based database.</p><p><strong>Methods and results: </strong>This nationwide time-stratified case-crossover study evaluated data of hospitalized patients with AAD from 1119 certified hospitals between 2012 and 2020 using the JROAD-DPC database. Conditional logistic regression and distributed lag non-linear models were used to investigate the association between average daily temperature and AAD-related hospitalization. Among the 96 812 cases analysed, the exposure-response curve between AT and AAD-related hospitalization showed an increase in the odds ratio for lower temperatures, with a peak at time -10°C (odds ratio: 2.28, 95% confidence interval: 1.92-2.71, compared with that at 20°C). The effects of temperature on lag days 0 and 1 were also significant.Stratified analyses showed a greater association between AT and AAD-related hospitalization for the following variables: older age (≥75 years), female sex (44.4%, the mean age ± SD was 76 ± 12 years), low body mass index (<22), winter season, and warmer regions.</p><p><strong>Conclusion: </strong>Low AT is associated with an increased risk of AAD-related hospitalization. Several susceptible groups are affected by cold temperatures and have a higher risk of hospitalization.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"317-324"},"PeriodicalIF":8.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142016808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between social determinants of health and cardiovascular and cancer mortality in cancer survivors: a prospective cohort study.","authors":"Jeffrey Shi Kai Chan, Danish Iltaf Satti, Yat Long Anson Ching, Quinncy Lee, Edward Christopher Dee, Kenrick Ng, Oscar Hou-In Chou, Tong Liu, Gary Tse, Agnes Lai","doi":"10.1093/eurjpc/zwae318","DOIUrl":"10.1093/eurjpc/zwae318","url":null,"abstract":"<p><strong>Aims: </strong>The cause-specific mortality implications of social determinants of health (SDOH) in cancer survivors were unclear. This study aimed to explore associations between SDOH and cardiovascular and cancer mortality in cancer survivors.</p><p><strong>Methods and results: </strong>Data from 2013 to 2017 National Health Interview Survey were used for this prospective cohort study. Social determinants of health were quantified using a 38 point, 6 domain score, with higher points indicating worse deprivation. Associations between SDOH and outcomes (primary: cardiovascular mortality; secondary: cancer and all-cause mortality) were assessed using cause-specific multivariable Cox regression, with cancer survivors and individuals without cancer modelled separately. Post hoc analyses were performed among cancer survivors to explore associations between each domain of SDOH and the risks of outcomes. Altogether, 37 882 individuals were analysed (4179 cancer survivors and 33 703 individuals without cancer). Among cancer survivors, worse SDOH was associated with higher cardiovascular [adjusted hazard ratio (aHR) 1.31 (1.02-1.68)], cancer [aHR 1.20 (1.01-1.42)], and all-cause mortality [aHR 1.16 (1.02-1.31)] when adjusted for demographics, comorbidities, and risk factors. Among individuals without cancer, SDOH was associated with cardiovascular mortality and all-cause when only adjusted for demographics, but not when further adjusted for comorbidities and risk factors; no associations between SDOH and cancer mortality were found. Among cancer survivors, psychological distress, economic stability, neighbourhood, physical environment and social cohesion, and food insecurity were varyingly associated with the outcomes.</p><p><strong>Conclusion: </strong>Social determinants of health were independently associated with all-cause, cardiovascular, and cancer mortality among cancer survivors but not among individuals without cancer. Different domains of SDOH may have different prognostic importance.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"336-347"},"PeriodicalIF":8.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Letter to the Editor regarding the article 'Exposure to workplace sexual harassment and risk of cardiometabolic disease: a prospective cohort study of 88 904 Swedish men and women'.","authors":"K C Prakash, Ida E H Madsen, Reiner Rugulies, Tianwei Xu, Mika Kivimaki, Linda L Magnusson Hanson","doi":"10.1093/eurjpc/zwae300","DOIUrl":"10.1093/eurjpc/zwae300","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"353-354"},"PeriodicalIF":8.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reassessing the association between age at menarche and cardiovascular disease: observational and Mendelian randomization analyses.","authors":"Lena Tschiderer, Sanne A E Peters, Yvonne T van der Schouw, Stephen Burgess, Janneke Luijken, Cheyenne Bijmolt, Houda Soliman, Adam S Butterworth, Angela M Wood, Tammy Y N Tong, Christina C Dahm, Lisa Seekircher, Anne Tjønneland, Lene Mellemkjær, Matthias B Schulze, Giovanna Masala, Sabina Sieri, Salvatore Panico, Carlotta Sacerdote, Jolanda M A Boer, W M Monique Verschuren, Carlota Castro-Espin, Dafina Petrova, Sandra M Colorado-Yohar, Conchi Moreno-Iribas, Elisabete Weiderpass, Alicia K Heath, Ioanna Tzoulaki, Peter Willeit, N Charlotte Onland-Moret","doi":"10.1093/eurjpc/zwaf051","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf051","url":null,"abstract":"<p><strong>Aims: </strong>Observational studies have shown a U-shaped association between age at menarche (AAM) and cardiovascular disease (CVD). We assessed non-linearity of the observational association and the potential causal relationship between AAM and CVD using data from the European Prospective Investigation into Cancer and Nutrition-Cardiovascular Disease (EPIC-CVD) study and the UK Biobank.</p><p><strong>Methods and results: </strong>We included women without pre-existing myocardial infarction (MI) or stroke at baseline. We estimated hazard ratios for incident MI, ischaemic and haemorrhagic stroke later in life using Cox regression in observational analyses and conducted non-linear Mendelian randomization (MR) based on fractional polynomials and linear MR based on inverse-variance weighted regression. We analysed 283 210 women with a median AAM of 13 (IQR 12-14) years in both EPIC-CVD and the UK Biobank, of which 8468 experienced a MI, 5501 an ischaemic and 1887 a haemorrhagic stroke. The association between AAM and MI and ischaemic stroke was U-shaped with higher risks in women aged ≤12 and ≥16 compared with those aged 13 years at menarche. Our MR analyses found no evidence for non-linearity between genetically proxied AAM and any CVD endpoint later in life, but each year higher genetically proxied AAM was related to a lower risk of MI (hazard ratio 0.92 [95% CI 0.86-0.99]), but not to ischaemic and haemorrhagic stroke.</p><p><strong>Conclusion: </strong>This study supported non-linear observational associations between AAM and MI and ischaemic stroke. MR analyses suggested a causal relationship between higher AAM and risk of MI without an indication for non-linearity. There was no support for a potential causal link with ischaemic and haemorrhagic stroke.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}