European journal of preventive cardiology最新文献

{"title":"Hepatic Steatosis in Cardiovascular-Kidney-Metabolic Syndrome: Fatty Liver Index as a Predictor of Cardiovascular Outcomes.","authors":"Byung Sik Kim, Hyun-Jin Kim, Hasung Kim, Jungkuk Lee, Sang Bong Ahn, Jeong-Hun Shin, Young-Hyo Lim","doi":"10.1093/eurjpc/zwaf396","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf396","url":null,"abstract":"<p><strong>Aims: </strong>Cardiovascular-kidney-metabolic (CKM) syndrome describes the interplay between metabolic dysfunction, chronic kidney disease, and cardiovascular disease. While this framework advances our understanding of interrelated pathophysiology across multiple organ systems, further exploring the liver's role may be beneficial. The fatty liver index (FLI) is a cost-effective indicator of hepatic steatosis; however, its prognostic role in CKM syndrome remains unclear.</p><p><strong>Methods: </strong>This retrospective cohort study used data of 1,497,913 adults enrolled in the Korean National Health Insurance Database between 2009 and 2012. Participants were classified into four CKM syndrome stages (0/1, 2, 3, and 4) and further stratified by FLI (<60 vs. ≥60). The primary composite outcomes were all-cause death, heart failure, stroke, and myocardial infarction.</p><p><strong>Results: </strong>Over an average follow-up of 12.60 ± 1.50 years, individuals with FLI ≥60 exhibited a 32% higher risk of the primary outcome (hazard ratio (HR) 1.324, 95% confidence interval (CI) 1.304-1.345, p < 0.001) compared to those with FLI <60. Each 1-standard deviation (SD) increment in the FLI (1-SD = 23.78) was associated with a 23% higher risk of the primary outcome. This dose-response relationship persisted across all CKM syndrome stages, with the most pronounced effect observed in earlier stages (0/1 and 2). A similar pattern was noted for the secondary outcomes.</p><p><strong>Conclusions: </strong>The FLI is an independent prognostic marker for cardiovascular outcomes across the CKM syndrome spectrum. Incorporating FLI into clinical practice could enhance early risk stratification and inform timely interventions, especially in patients at early stages of CKM syndrome, thereby potentially improving long-term cardiometabolic and renal outcomes.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Composite Indices to Predicted Heart Failure Risk in Older Diabetic and Hypertensive Patients Remain to be Verified.","authors":"Xinyu Liu, Xiaoming Zhou","doi":"10.1093/eurjpc/zwaf363","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf363","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remnant Cholesterol in CHARLS: Unaddressed Dynamic Changes and Clinical Confounders in CKM Progression Analysis.","authors":"Wanhaier Abudoureheman, Fan Zhang, Qiuzi Sun","doi":"10.1093/eurjpc/zwaf391","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf391","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific associations between blood pressure in early midlife and arterial stiffness 27 years later: The Hordaland Health Study.","authors":"Ester Kringeland, Helga Midtbø, Annabel Eide Ohldieck, Arleen Aune, Eva Gerdts","doi":"10.1093/eurjpc/zwaf379","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf379","url":null,"abstract":"<p><strong>Background and aims: </strong>Little is known about sex-specific associations between elevated blood pressure (BP) in early midlife and presence of increased arterial stiffness later in life.</p><p><strong>Methods: </strong>BP was measured in 1,127 women and 938 men, mean age 42 years (baseline), and categorized as non-elevated BP (<120/70mmHg), elevated BP (120-139/70-89mmHg) and hypertension (≥140/90mmHg). Increased arterial stiffness was identified as carotid-femoral pulse wave velocity (cf-PWV) >10 m/s. Associations between BP at baseline with increased arterial stiffness 27 years later were assessed in logistic regression analysis adjusted for baseline body mass index, diabetes, smoking, heart rate, lipids, age and education, and reported as odds ratios (OR) and 95% confidence intervals (CI).</p><p><strong>Results: </strong>At baseline, 62% of women and 67% of men had elevated BP and 9% of women vs 26% of men had hypertension (p<0.001). At follow-up, 17% of women and 31% of men had increased arterial stiffness (p<0.001). In adjusted analysis, having elevated BP or hypertension at baseline as compared to non-elevated BP were both associated with increased arterial stiffness 27 years later in women (OR 2.78 [95% CI 1.74-4.42] and OR 4.62 [95% CI 2.48-8.58]), but not in men (OR 1.10 [95% CI 0.58-2.10] and OR 1.33 [95% CI 0.67-2.66]), p for sex-interaction 0.01.</p><p><strong>Conclusions: </strong>In the Hordaland Health Study, having elevated BP or hypertension in early midlife were associated with increased arterial stiffness 27 years later in women, but not in men. These findings underscore the importance of managing BP in early midlife for optimal CVD prevention in women.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144511738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Concepts in the Management of Hypertension in Hypertensive Disorders of Pregnancy - A Systematic Review of International Guidelines.","authors":"Marianna Danielli, Thurkga Moothathamby, Mohammed Y Khanji, Kate Wiles, Ajay Gupta","doi":"10.1093/eurjpc/zwaf373","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf373","url":null,"abstract":"<p><strong>Background and objective: </strong>Hypertensive disorders of pregnancy (HDP) are a leading cause of adverse maternal and perinatal outcomes worldwide. This systematic review aims to compare international practice guidelines for the management gestational hypertension (GH) and pre-eclampsia (PE). Our objective is to identify similarities and differences in the classification, diagnosis and management of these condition.</p><p><strong>Methods: </strong>Published guidelines from January 2010 to April 2024 were searched, utilising MEDLINE, EMBASE, the Emergency Care Research Institute (ECRI) Guidelines Trust, and the Guidelines International Network's website (GIN) as databases. Guidelines were included if in English and not derived from other guidelines. All the guidelines were compared for definitions, diagnostic criteria, recommendations for pharmacological and non-pharmacological management, and contraindications. The AGREE II score tool was used to assess quality of included guidelines.</p><p><strong>Results: </strong>The 12 included guidelines were consistent in their definition of GH and PE and which antihypertensive agents to avoid. Guidelines differed in the recommended blood pressure thresholds for initiation of antihypertensive medication and treatment targets. The use of aspirin was universally recommended, but guidance on non-pharmacological interventions was controversial.</p><p><strong>Conclusion: </strong>All guidelines acknowledge the significant morbidity associated with HDP and advocate for timely diagnosis and management. However, there are significant discrepancies in many aspects including definition and pharmacological management. More research is needed to understand optimal blood pressure thresholds at which to initiate antihypertensive medication regimens, the choice of antihypertensive, and the efficacy and benefits of non-pharmacological interventions in HDP. These findings exhibit knowledge gaps, which should be addressed in future research.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144526945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal denervation improves capillary density in hypertensive patients.","authors":"Agnes Bosch, Joanna M Harazny, Axel Schmid, Dennis Kannenkeril, Marina Karg, Venera Bytyqi, Hannah Roth, Mario Schiffer, Michael Uder, Roland E Schmieder","doi":"10.1093/eurjpc/zwaf387","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf387","url":null,"abstract":"<p><strong>Background: </strong>Cardiovascular (CV) outcome data after endovascular renal denervation (RDN) are sparse. Capillary density determines total peripheral resistance and thus blood pressure. Microvascular changes of the retinal vessels are a marker of hypertension-mediated organ damage (HMOD). We report data on capillary density six and twelve months after RDN.</p><p><strong>Methods: </strong>Endovascular RDN was performed in 132 patients with uncontrolled hypertension confirmed by 24-hour ambulatory blood pressure (ABP). Office and 24-hour ABP were measured at baseline and 6 and 12 months after RDN. In parallel, retinal capillary density was measured by scanning laser Doppler flowmetry (Heidelberg Retina Flowmeter, Heidelberg Engineering, Germany). This technique uses the retinal microvasculature as a mirror of the microvasculature in the systemic circulation.</p><p><strong>Results: </strong>24-hour ABP was reduced from 151/88 mmHg to 143/84 mmHg (six months after RDN) and to 142/82 mmHg (12 months after RDN) (all p <0.001). Retinal capillary density was improved both six and twelve months after RDN, as evidenced by an increase in CapA (1691 ± 805 µm2 at baseline vs. 1853 ± 948 µm2 six months after RDN, p = 0.021 and 1967 ± 980 µm2 twelve months after RDN, p = 0.034, (p = 0.097 for change between six and twelve months)).</p><p><strong>Conclusions: </strong>In patients with arterial hypertension, blood pressure reduction by RDN increased retinal capillary density both six and twelve months after the procedure.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2020 ESC sport disciplines classification: a proposal for an update.","authors":"Antonio Pelliccia, Maria Rosaria Squeo, Armando Ferrera, Viviana Maestrini, Sara Monosilio, Federica Mango, Andrea Serdoz, Giuseppe Di Gioia","doi":"10.1093/eurjpc/zwaf385","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf385","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor regarding \"Effect of exercise training in patients with chronotropic incompetence and heart failure with preserved ejection fraction: the TRAINING-HR randomized clinical trial\".","authors":"Patricia Palau, Laura López, Julio Núñez","doi":"10.1093/eurjpc/zwaf359","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf359","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoprotein(a) Testing and Levels among Patients with Atherosclerotic Cardiovascular Disease: A Large Single-Centre Experience from the United Arab Emirates.","authors":"Yosef Manla, Laila AbdelWareth, Yazan Aljabery, Hani Sabbour, Ronney Shantouf, Fatemeh Mohammad, Bartlomiej Piechowski-Jozwiak, Terrence Lee St John, Wael Almahmeed","doi":"10.1093/eurjpc/zwaf374","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf374","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Semaglutide on Mortality and Cardiovascular Events in Patient at High Cardiovascular Risk: An Updated Systematic Review and Meta-analysis.","authors":"Marco Spagnolo, Davide Capodanno","doi":"10.1093/eurjpc/zwaf358","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf358","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144495288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}