European journal of preventive cardiology最新文献

{"title":"Recalibrating Risk: The Promise and Limits of Metabolomics-Enriched Models.","authors":"Michael D Shapiro","doi":"10.1093/eurjpc/zwaf205","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf205","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipoprotein(a) and New-Onset Atrial Fibrillation: Where Does the Evidence Lead Us?","authors":"Yang Chen, Garry McDowell, Gregory Y H Lip","doi":"10.1093/eurjpc/zwaf204","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf204","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing Diagnostic Strategies for Sudden Arrhythmic Death Syndrome Families; Time to Focus on Age and Sex differences?","authors":"E Androulakis, P E Vardas","doi":"10.1093/eurjpc/zwaf188","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf188","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Examining the Relationship Between Anthropometric and Body Composition measures with Coronary Heart Disease Events: The Multi-Ethnic Study of Atherosclerosis.","authors":"Amier Haidar, Richard Kronmal, Matthew Allison, Karol Watson, Preethi Srikanthan, Tamara Horwich","doi":"10.1093/eurjpc/zwaf212","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf212","url":null,"abstract":"<p><strong>Background: </strong>Obesity, traditionally measured using body mass index (BMI), is considered a significant risk factor for the development of cardiovascular disease. However, there have been mixed findings regarding the association between obesity and cardiovascular events in part due to the way it is measured. Major limitations exist with the use of BMI as it cannot assess body composition or fat distribution, and thus fails to account for the separate roles of muscle and fat mass.</p><p><strong>Objective: </strong>To examine the relationship between various measures of body composition including fat mass (FM), fat free mass (FFM), waist-to-height ratio, waist circumference, and BMI, and coronary heart disease (CHD) events, from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort.</p><p><strong>Methods: </strong>MESA is a population-based cohort study of 6814 men and women, aged between 45 and 85 years, without clinically apparent CVD. FM and FFM at baseline (Exam 1) was estimated using multiplicative power equations formulated from bioelectrical impedance analysis (BIA) measurements. Multivariable Cox regression models were used to estimate the hazard ratio (HR) and 95% confidence interval (CI) for 10-year incident hard CHD events (non-fatal myocardial infarction (MI), resuscitated cardiac arrest, and death resulting from CHD) for FM/FFM, waist-to-height ratio, waist circumference, and BMI.</p><p><strong>Results: </strong>Higher FM was associated with higher risk of hard CHD events, with a hazard ratio of 1.64 (1.09-2.48) per standard deviation (SD) unit increase (P-value 0.019). FFM was associated with a lower risk of CHD, with a hazard ratio of 0.24 (0.08-0.76) per SD unit increase of FFM (P-value 0.014). Waist-to-height ratio had a hazard ratio of 1.21 (1.08-1.35) (P-value 0.001) per SD unit increase in the ratio and was significantly associated with a higher risk of hard CHD events, as was waist circumference with a hazard ratio of 1.14 (1.03-1.28) (P-value 0.016) per SD unit increase. BMI had a hazard ratio of 1.08 (0.97-1.21) (P-value 0.158) and was not significantly associated with a 10-year risk of hard CHD events.</p><p><strong>Conclusion: </strong>Higher FM, waist-to-height ratio, and waist circumference were associated with increased risk for hard CHD events while higher FFM was associated with decreased risk. This highlights the potential importance of lifestyle interventions to build muscle and minimize adiposity for the prevention of CVD and strengthens the call for the inclusion of alternative methodologies to define obesity and measure body composition in the clinical setting.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variations in blood pressure after a 75g oral glucose load and their implications for detecting hypertension and postprandial hypotension in Chinese adults: a cross-sectional study.","authors":"Xiaoying Zhou, Tongzhi Wu, Miaomiao Sang, Shanhu Qiu, Bei Wang, Haijian Guo, Kaili Li, Qing Wang, Xinling Wang, Qingyun Chen, Hong Li, Sunjie Yan, Michael Horowitz, Christopher K Rayner, Duolao Wang, Danny Liew, Karen L Jones, Zilin Sun","doi":"10.1093/eurjpc/zwaf217","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf217","url":null,"abstract":"<p><strong>Aims: </strong>Current hypertension guidelines fail to discriminate between fasting and postprandial blood pressure (BP) measurements. Meal ingestion often triggers a marked increase in splanchnic blood flow, potentially inducing a sustained fall in systolic BP of ≥20mmHg, termed postprandial hypotension (PPH). This study aimed to evaluate BP responses to a 75g glucose drink and its implications for detecting hypertension and PPH in community-dwelling adults.</p><p><strong>Methods: </strong>A stratified multi-stage random sampling method was used to obtain a nationally representative sample of 4429 adult residents between April 2020 and January 2021 in China. BP and heart rate (HR) were measured before, and 1 and 2 hours after, a 75g glucose drink.</p><p><strong>Results: </strong>When fasting, 38.4% of the study population had high BP (BP ≥140/90mmHg). Following the glucose drink, SBP and DBP decreased (SBP by 6.2 [95% CI: 5.8-6.6]mmHg and 8.1 [7.7-8.5]mmHg, DBP by 4.7 [4.4-4.9]mmHg and 6.1 [5.8-6.4]mmHg), and HR increased (by 4.3 [4.0-4.5]bpm and 2.6 [2.4-2.9]bpm) at 1 and 2 hours (P <0.001 for all), with only 30.9% and 27.0% of the study population having high BP at 1 and 2 hours, respectively. After adjustment for age and sex distribution, 19.9% of the general population was estimated to have PPH. PPH was associated with an increased risk of combined cardiovascular disease and stroke.</p><p><strong>Conclusions: </strong>Ingestion of a 75g glucose drink often lowers BP, frequently leading to PPH and influencing the detection of hypertension. Accordingly, guidelines for measurements of BP and interpretation of outcomes should consider the potential impact of meal ingestion on BP.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remnant cholesterol reduction for ASCVD prevention: modelling in the Copenhagen General Population Study.","authors":"Karen Hvid, Mie Balling, Shoaib Afzal, Børge G Nordestgaard","doi":"10.1093/eurjpc/zwaf203","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf203","url":null,"abstract":"<p><strong>Aims: </strong>Elevated remnant cholesterol is a causal factor for atherosclerotic cardiovascular disease (ASCVD); however, whether aggressive lowering will reduce ASCVD is unclear. In women and men, we tested the hypothesis that aggressive lowering of remnant cholesterol has the potential for substantial ASCVD reduction. This was tested using modelling of cohort data.</p><p><strong>Methods: </strong>From the Copenhagen General Population Study, 56 422 women and 43 952 men without a history of ASCVD were recruited from 2003 through 2015. They were subsequently followed in national Danish health registries until December 2021 for incident ASCVD.</p><p><strong>Results: </strong>During a median follow-up of 12 years, 4 946 women and 6 043 men developed ASCVD. In women at very-high cardiovascular risk, 2 mmol/L (77 mg/dL) lower levels of remnant cholesterol from 3 mmol/L (116 mg/dL) likely reduces absolute 10-year risk of ASCVD by 17% and 13% in statin users and non-users; corresponding values in men were 20% and 15%, respectively. Corresponding values by 1 mmol/L (39 mg/dL) lower remnant cholesterol were 10% and 7% in women and 11% and 9% in men, respectively. Similar values are also provided for lower starting remnant cholesterol levels, different lowering of remnant cholesterol, and for lower baseline cardiovascular risk.</p><p><strong>Conclusions: </strong>In women and men, aggressive lowering of remnant cholesterol has the potential for substantial ASCVD reduction. Estimated absolute risk reduction was larger in statin users versus non-users and in men versus women, likely because statin users versus non-user and men versus women are at higher baseline absolute risk.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges in Defining, Measuring and Calculating Remnant Cholesterol.","authors":"Robert DuBroff, Paula Byrne","doi":"10.1093/eurjpc/zwaf201","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf201","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Prevalence of Myocardial Fibrosis using Cardiovascular MRI in Individuals with Cardiometabolic Conditions.","authors":"Trecy Gonçalves, Théo Pezel","doi":"10.1093/eurjpc/zwaf186","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf186","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tackling Metals to Advance Cardiovascular Health.","authors":"Irene Martinez-Morata, Katlyn McGraw, Ana Navas-Acien","doi":"10.1093/eurjpc/zwaf189","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf189","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of patient characteristics and health outcomes between self-selected centre-based cardiac rehabilitation and hybrid cardiac telerehabilitation: a prospective cohort study.","authors":"Prisca Eser, Matteo Pini, Thomas Vetsch, Thimo Marcin, Seraina Berni, Regula Burri, Flurina Casanova, Sarina Huber, Franziska Gurschler, Claudia Boeni, Michael Hubli, Nico Herwegh, Andreas Zimmermann, Laura Hess, Sven Schmutz, Matthias Wilhelm","doi":"10.1093/eurjpc/zwaf107","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf107","url":null,"abstract":"<p><strong>Aims: </strong>Data on self-selected modes of delivery of cardiac rehabilitation (CR) are limited. This study compared centre-based CR (cbCR) with hybrid cardiac telerehabilitation (hCTR) in terms of patient characteristics, change in physical and mental functioning, and achievement of guideline-directed treatment targets.</p><p><strong>Methods and results: </strong>From May 2022 to December 2023, consecutive patients with cardiovascular diseases were enrolled at a tertiary centre into a 3 month cbCR or hCTR programme based on shared decision-making. Changes in exercise capacity, anxiety, depression, and health-related quality of life (hrQoL) scores from admission to the discharge visit were compared between CR modalities. The achievement of two-step blood pressure and LDL-cholesterol (LDL-C) goals, as well as the HbA1c goal in patients with diabetes at the discharge visit, was compared between CR modalities. Out of 1292 patients screened, 406 (21% females, age 60.4 ± 12.7 years) were eligible and completed the study. Of those, 72% chose cbCR and 28% chose hCTR. Patients in hCTR were 3 years younger and exhibited higher baseline peak VO2 (91 vs. 80% of predicted), better hrQoL, and lower depression and anxiety scores. No significant differences were found in improvements in physical or mental functioning or in meeting blood pressure and HbA1c targets between the two groups. A smaller proportion of hCTR participants achieved the LDL-C Step I target (56 vs. 69% in cbCR).</p><p><strong>Conclusion: </strong>Overall, hCTR attracted slightly younger patients with better baseline health, but both modalities showed similar effects on most health outcomes. Centre-based cardiac rehabilitation was associated with tighter lipid control, which could be related to more intense counselling or patient preference.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}