European journal of preventive cardiology最新文献

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Cumulative blood pressure exposure and global and regional cardiac structure and function: the MESA study. 累积血压暴露与整体和局部心脏结构和功能:MESA研究。
IF 7.5 2区 医学
European journal of preventive cardiology Pub Date : 2025-10-10 DOI: 10.1093/eurjpc/zwaf163
Soroush Masrouri, Peyman Tabnak, Parag A Chevli, Saeid Mirzai, Leandro Slipczuk, Sujethra Vasu, Joao A C Lima, Michael D Shapiro
{"title":"Cumulative blood pressure exposure and global and regional cardiac structure and function: the MESA study.","authors":"Soroush Masrouri, Peyman Tabnak, Parag A Chevli, Saeid Mirzai, Leandro Slipczuk, Sujethra Vasu, Joao A C Lima, Michael D Shapiro","doi":"10.1093/eurjpc/zwaf163","DOIUrl":"10.1093/eurjpc/zwaf163","url":null,"abstract":"<p><strong>Aims: </strong>This study examined the associations between decade-long cumulative blood pressure (BP) exposure and global/regional myocardial structure and function independent of current BP levels.</p><p><strong>Methods and results: </strong>We analysed 3015 adults (aged 69.0 ± 9.2 years) from the Multi-Ethnic Study of Atherosclerosis (MESA) who underwent cardiac magnetic resonance (CMR) imaging at Year 10 (Exam 5, 2010-12). Measures included left ventricular (LV) parameters, global/regional myocardial function via tagged CMR, interstitial myocardial fibrosis via T1-mapping measures (native T1 and extracellular volume fraction), and myocardial scar via late gadolinium enhancement. We used cumulative exposure to BP through baseline and up to Exam 5 (millimetres of mercury × year) to represent long-term exposure to BP levels. Linear regression, logistic regression, and generalized additive models were used to quantify the association of cumulative BP parameters with measures of cardiac structure and function. Higher cumulative systolic BP (SBP), independent of current SBP, correlated with increased LV mass index [1.93 g/m2 per standard deviation (SD)], worse global/regional circumferential strain (0.24-0.38% lower absolute values per SD), and greater myocardial scar risk [odds ratio (OR): 1.36, 95% confidence interval (CI): 1.02-1.82 per SD]. Cumulative diastolic BP (DBP) was associated with circumferential strain, showing nearly J-shaped relationships after adjusting for current DBP (all P < 0.05). In non-hypertensive individuals with BP consistently below the hypertension threshold, cumulative SBP remained significantly associated with LV mass index and strain but not myocardial scar (OR: 1.53, 95% CI: 0.82-2.87, P = 0.19).</p><p><strong>Conclusion: </strong>Higher cumulative BP was associated with worse global and regional cardiac structure/function and myocardial scar, independent of a single BP at the time of imaging, and was still observed to some extent in non-hypertensive individuals who consistently maintained BP levels below the hypertension threshold.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"1296-1309"},"PeriodicalIF":7.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intensive systolic blood pressure control in patients with or without worsening renal function. 有或无肾功能恶化患者的强化收缩压控制。
IF 7.5 2区 医学
European journal of preventive cardiology Pub Date : 2025-10-10 DOI: 10.1093/eurjpc/zwaf184
Xiaoli Xu, Xiaoyun Zhang, Siyu Wang, Kan Wang, Yu Xiang, Yuanyue Zhu, Xuan Zhao, Yueyue Wang, Xi Meng, Zhiyun Zhao, Tiange Wang, Jie Zheng, Min Xu, Jieli Lu, Mian Li, Weiqing Wang, Guang Ning, Yufang Bi, Yu Xu
{"title":"Intensive systolic blood pressure control in patients with or without worsening renal function.","authors":"Xiaoli Xu, Xiaoyun Zhang, Siyu Wang, Kan Wang, Yu Xiang, Yuanyue Zhu, Xuan Zhao, Yueyue Wang, Xi Meng, Zhiyun Zhao, Tiange Wang, Jie Zheng, Min Xu, Jieli Lu, Mian Li, Weiqing Wang, Guang Ning, Yufang Bi, Yu Xu","doi":"10.1093/eurjpc/zwaf184","DOIUrl":"10.1093/eurjpc/zwaf184","url":null,"abstract":"<p><strong>Aims: </strong>Intensive systolic blood pressure (BP) control is associated with a lower risk of cardiovascular disease (CVD) but an increased risk of worsening renal function (WRF). This study aimed to investigate whether intensive BP control should be continued after WRF.</p><p><strong>Methods and results: </strong>We performed a post hoc analysis of SPRINT (Systolic Blood Pressure Intervention Trial). Worsening renal function was defined as an estimated glomerular filtration rate decline of ≥30% during follow-up from baseline. The associations between WRF, efficacy and safety outcomes, and BP treatment were evaluated using time-updated Cox proportional hazard models. Among 9211 participants included in this analysis, 1310 participants (14.2%) experienced WRF during follow-up. The intensive BP treatment significantly reduced the risk of the primary outcome compared with the standard BP treatment among patients with WRF [hazard ratio (HR): 0.54; 95% confidence interval (CI): 0.32-0.90] and without WRF (HR: 0.82; 95% CI: 0.68-0.98; Pinteraction = 0.224). In addition, the intensive BP treatment significantly reduced the risk of all-cause death among patients with WRF (HR: 0.40; 95% CI: 0.23-0.68), but not among patients without WRF (HR: 0.84; 95% CI: 0.67-1.07; Pinteraction = 0.046). Risks of safety events were similar between BP treatment groups among patients with and without WRF. Results were similar among participants who experienced WRF early or late during the intervention.</p><p><strong>Conclusion: </strong>Intensive BP treatment increased the risk of WRF compared with standard BP treatment. However, intensive BP treatment was associated with reduced risks of CVD and all-cause mortality compared with standard BP treatment in patients experiencing WRF, without increasing adverse events.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"1361-1368"},"PeriodicalIF":7.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk of hypertension and heart failure linked to high-normal serum sodium and tonicity in general healthcare electronic medical records. 高血压和心力衰竭的风险与高正常血清钠和一般医疗保健电子医疗记录。
IF 7.5 2区 医学
European journal of preventive cardiology Pub Date : 2025-10-10 DOI: 10.1093/eurjpc/zwaf232
Jonathan Rabinowitz, Mahmoud Darawshi, Nuriel Burak, Manfred Boehm, Natalia I Dmitrieva
{"title":"Risk of hypertension and heart failure linked to high-normal serum sodium and tonicity in general healthcare electronic medical records.","authors":"Jonathan Rabinowitz, Mahmoud Darawshi, Nuriel Burak, Manfred Boehm, Natalia I Dmitrieva","doi":"10.1093/eurjpc/zwaf232","DOIUrl":"10.1093/eurjpc/zwaf232","url":null,"abstract":"<p><strong>Aims: </strong>Population ageing is fuelling an epidemic of age-related chronic diseases. Managing risk factors and lifestyle interventions have proven effective in disease prevention. Recent epidemiological studies have suggested poor hydration as a modifiable risk factor, linked to a higher risk of chronic diseases. We evaluate whether hydration-related markers, serum sodium and tonicity, can serve as risk factors for hypertension and heart failure informing hydration-focused interventions in general health care.</p><p><strong>Methods and results: </strong>We analysed 407 187 adults (18-104 years) from 20-year electronic medical records from Israel's Leumit Healthcare Services. We included individuals without significant chronic diseases and water balance issues, having normal serum sodium (135-146 mmol/L). Cox proportional hazards models were used to assess the risk of developing hypertension and heart failure. Our analysis showed an increased risk of hypertension with higher serum sodium levels: a 13% rise at 140-142 mmol/L and 29% for levels above 143 mmol/L [hazard ratio (HR) 1.29, 95% confidence interval (CI): 1.25-1.33]. Tonicity over 287 mosmol/kg was associated with a 19% increased risk of hypertension (HR 1.19, 95% CI: 1.17-1.22). The risk of heart failure also increased, reaching 20% for sodium above 143 mmol/L (HR 1.20, 95% CI: 1.12-1.29) and 15% for tonicity above 289 mosmol/kg (HR 1.16, 95% CI: 1.08-1.21). Among current healthy Leumit members, 19% had serum sodium within the 143-146 mmol/L range and 39% were in the 140-142 mmol/L range.</p><p><strong>Conclusion: </strong>A serum sodium and tonicity exceeding 140 mmol/L and 287 mosmol/kg are associated with increased risk of hypertension and heart failure in the general Israeli population. These thresholds could be used to identify individuals at risk, warranting additional clinical evaluations and guiding preventive intervention.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"1371-1381"},"PeriodicalIF":7.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction. 修正。
IF 7.5 2区 医学
European journal of preventive cardiology Pub Date : 2025-10-10 DOI: 10.1093/eurjpc/zwaf389
{"title":"Correction.","authors":"","doi":"10.1093/eurjpc/zwaf389","DOIUrl":"10.1093/eurjpc/zwaf389","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"1413"},"PeriodicalIF":7.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of flavan-3-ols on blood pressure and endothelial function in diverse populations: a systematic review and meta-analysis of randomized controlled trials. 黄烷-3-醇对不同人群血压和内皮功能的影响:随机对照试验的系统回顾和荟萃分析
IF 7.5 2区 医学
European journal of preventive cardiology Pub Date : 2025-10-10 DOI: 10.1093/eurjpc/zwaf173
Vasiliki Lagou, Arno Greyling, Mario G Ferruzzi, Simon S Skene, Joy Dubost, Ayse Demirkan, Inga Prokopenko, Julie Shlisky, Ana Rodriguez-Mateos, Christian Heiss
{"title":"Impact of flavan-3-ols on blood pressure and endothelial function in diverse populations: a systematic review and meta-analysis of randomized controlled trials.","authors":"Vasiliki Lagou, Arno Greyling, Mario G Ferruzzi, Simon S Skene, Joy Dubost, Ayse Demirkan, Inga Prokopenko, Julie Shlisky, Ana Rodriguez-Mateos, Christian Heiss","doi":"10.1093/eurjpc/zwaf173","DOIUrl":"10.1093/eurjpc/zwaf173","url":null,"abstract":"<p><strong>Aims: </strong>Flavan-3-ols, found in cocoa, tea, and certain fruits, show promise in improving blood pressure (BP) and vascular function, but are currently not used for cardiovascular prevention. This meta-analysis evaluated the effects of flavan-3-ol-rich interventions on BP and endothelial function.</p><p><strong>Methods and results: </strong>PubMed was searched for randomized controlled trials (RCTs) published 1946-03/2024 on BP and flow-mediated dilation after flavan-3-ol-rich food, beverage, or supplement intake. Random-effects meta-analysis of 109 publications including 145 RCTs and 5205 participants was performed (PROSPERO: CRD42023454691). Flavan-3-ol interventions included epicatechin, epigallocatechin-gallate, cocoa products, tea, grape extract, and apples delivering 586 mg (95% CI 510, 662) total flavan-3-ols. Interventions decreased office (-2.8 [95% CI -3.9, -1.7]/-2.0 [-2.6, -1.3] mmHg) and 24 h-ambulatory BP (-3.7 [-5.8, -1.6]/-2.6 [-4.5, -0.8] mmHg) after chronic repetitive consumption. Effects were larger with elevated and hypertensive baseline BP or categorical hypertension (office: -5.9 [-10.0, -1.8]/-2.7 [-4.4, -1.0] mmHg, 24 h ABP: -6.8 [-16.3, 2.8]/-5.1 [-12.5, 2.2] mmHg). Meta-regression analysis confirmed that the magnitude of BP lowering was inversely related to baseline BP, but not to proportion of participants with CVD, diabetes mellitus, and study duration across all studies, and was dose-dependently related to epicatechin dose only in cocoa studies. Flow-mediated dilation increased after acute (+2.0% [1.6, 2.3]) and repetitive (+1.7% [1.3, 2.2]) consumption independent of BP. Reported adverse events were minor and low (0.4%). The considerable heterogeneity of effect sizes (I2 > 50%) between studies was not explained by the investigated factors limiting the strength of evidence to 'moderate'.</p><p><strong>Conclusion: </strong>Flavan-3-ol-rich foods considerably reduce elevated BP and improve endothelial function independent of blood pressure supporting their use for cardiovascular prevention.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"1322-1334"},"PeriodicalIF":7.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Permissive hypercreatinaemia and intensive blood pressure control. 容许性高肌酐血症和强化血压控制。
IF 7.5 2区 医学
European journal of preventive cardiology Pub Date : 2025-10-10 DOI: 10.1093/eurjpc/zwaf311
John P McCormick, John W McEvoy
{"title":"Permissive hypercreatinaemia and intensive blood pressure control.","authors":"John P McCormick, John W McEvoy","doi":"10.1093/eurjpc/zwaf311","DOIUrl":"10.1093/eurjpc/zwaf311","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"1369-1370"},"PeriodicalIF":7.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Folate deficiency and hypertension: new evidence of a causal relationship and potential for preventive strategies through improving folate status. 叶酸缺乏和高血压:通过改善叶酸状态的因果关系和潜在预防策略的新证据。
IF 7.5 2区 医学
European journal of preventive cardiology Pub Date : 2025-10-10 DOI: 10.1093/eurjpc/zwaf078
Helene McNulty
{"title":"Folate deficiency and hypertension: new evidence of a causal relationship and potential for preventive strategies through improving folate status.","authors":"Helene McNulty","doi":"10.1093/eurjpc/zwaf078","DOIUrl":"10.1093/eurjpc/zwaf078","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"1319-1321"},"PeriodicalIF":7.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Variations in blood pressure after a 75 g oral glucose load and their implications for detecting hypertension and postprandial hypotension in Chinese adults: a cross-sectional study. 中国成年人口服75g葡萄糖负荷后的血压变化及其对高血压和餐后低血压检测的意义:一项横断面研究
IF 7.5 2区 医学
European journal of preventive cardiology Pub Date : 2025-10-10 DOI: 10.1093/eurjpc/zwaf217
Xiaoying Zhou, Tongzhi Wu, Miaomiao Sang, Shanhu Qiu, Bei Wang, Haijian Guo, Kaili Li, Qing Wang, Xinling Wang, Qingyun Chen, Hong Li, Sunjie Yan, Michael Horowitz, Christopher K Rayner, Duolao Wang, Danny Liew, Karen L Jones, Zilin Sun
{"title":"Variations in blood pressure after a 75 g oral glucose load and their implications for detecting hypertension and postprandial hypotension in Chinese adults: a cross-sectional study.","authors":"Xiaoying Zhou, Tongzhi Wu, Miaomiao Sang, Shanhu Qiu, Bei Wang, Haijian Guo, Kaili Li, Qing Wang, Xinling Wang, Qingyun Chen, Hong Li, Sunjie Yan, Michael Horowitz, Christopher K Rayner, Duolao Wang, Danny Liew, Karen L Jones, Zilin Sun","doi":"10.1093/eurjpc/zwaf217","DOIUrl":"10.1093/eurjpc/zwaf217","url":null,"abstract":"<p><strong>Aims: </strong>Current hypertension guidelines fail to discriminate between fasting and postprandial blood pressure (BP) measurements. Meal ingestion often triggers a marked increase in splanchnic blood flow, potentially inducing a sustained fall in systolic BP of ≥20 mmHg, termed postprandial hypotension (PPH). This study aimed to evaluate BP responses to a 75 g glucose drink and its implications for detecting hypertension and PPH in community-dwelling adults.</p><p><strong>Methods and results: </strong>A stratified multi-stage random sampling method was used to obtain a nationally representative sample of n = 4429 adult residents between April 2020 and January 2021 in China. BP and heart rate (HR) were measured before, and 1 and 2 h after, a 75 g glucose drink. When fasting, 38.4% of the study population had high BP (BP ≥140/90 mmHg). Following the glucose drink, SBP and DBP decreased (SBP by 6.2 [95% CI: 5.8, 6.6] mmHg and 8.1 [7.7, 8.5] mmHg, DBP by 4.7 [4.4, 4.9] mmHg and 6.1 [5.8, 6.4] mmHg), and HR increased (by 4.3 [4.0, 4.5] bpm and 2.6 [2.4, 2.9] bpm) at 1 and 2 h (P < 0.001 for all), with only 30.9% and 27.0% of the study population having high BP at 1 and 2 h, respectively. After adjustment for age and sex distribution, 19.9% of the general population was estimated to have PPH. Postprandial hypotension was associated with an increased risk of combined cardiovascular disease and stroke.</p><p><strong>Conclusion: </strong>Ingestion of a 75 g glucose drink often lowers BP, frequently leading to PPH and influencing the detection of hypertension. Accordingly, guidelines for measurements of BP and interpretation of outcomes should consider the potential impact of meal ingestion on BP.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"1382-1391"},"PeriodicalIF":7.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: A family-based strategy to identify and prevent premature cardiovascular disease: a feasibility pilot study. 更正:以家庭为基础的识别和预防过早心血管疾病的战略:可行性试点研究。
IF 7.5 2区 医学
European journal of preventive cardiology Pub Date : 2025-10-10 DOI: 10.1093/eurjpc/zwaf393
{"title":"Correction to: A family-based strategy to identify and prevent premature cardiovascular disease: a feasibility pilot study.","authors":"","doi":"10.1093/eurjpc/zwaf393","DOIUrl":"10.1093/eurjpc/zwaf393","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"1412"},"PeriodicalIF":7.5,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ten-year Predictive Performance of Cardiovascular Risk Models in Adult Survivors of Allogeneic Hematopoietic Stem-Cell Transplant. 同种异体造血干细胞移植成年幸存者心血管风险模型的十年预测性能
IF 7.5 2区 医学
European journal of preventive cardiology Pub Date : 2025-10-09 DOI: 10.1093/eurjpc/zwaf644
Osnat Itzhaki Ben Zadok, Filip Gnesin, Anju Nohria
{"title":"Ten-year Predictive Performance of Cardiovascular Risk Models in Adult Survivors of Allogeneic Hematopoietic Stem-Cell Transplant.","authors":"Osnat Itzhaki Ben Zadok, Filip Gnesin, Anju Nohria","doi":"10.1093/eurjpc/zwaf644","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf644","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145257630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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