European journal of preventive cardiology最新文献

{"title":"Dose-Response Associations of Exercise Modalities With Cardiorespiratory Fitness in Heart Failure: A Systematic Review and Bayesian Network Meta-Analysis.","authors":"Wei Zhang, Minghui Du, Yixing Zhan, Zhiyuan Zhang, Longwei Chen, Jie Dong","doi":"10.1093/eurjpc/zwag560","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag560","url":null,"abstract":"<p><strong>Aims: </strong>Exercise training improves cardiorespiratory fitness in patients with heart failure, yet the dose-response relationship across different exercise modalities remains unclear. This study aimed to evaluate the effects of different exercise modalities and their standardized doses on peak oxygen uptake (VO2peak) in patients with heart failure.</p><p><strong>Methods: </strong>We systematically searched multiple databases from inception through March 2026 for randomized controlled trials comparing exercise interventions with controls. Exercise modalities were categorized as interval aerobic training (IAT), continuous aerobic training (CAT), resistance training (RT), mind-body training (MBT), and their combinations. Exercise dose was uniformly quantified as weekly metabolic equivalents (MET-min/week). A Bayesian model-based network dose-response meta-analysis was performed.</p><p><strong>Results: </strong>A total of 100 trials involving 5,353 patients were included. The dose-response relationship followed an Emax curve, with ED50 values clustering around 80-90 MET-min/week. A weekly dose of 500 MET-min yielded considerable benefit, and 750-1000 MET-min approached maximal benefit for nearly all modalities. The top three ranked interventions were IAT (Emax = 3.50, 95% CrI: 2.49-4.60), RT (Emax = 3.66, 95% CrI: 1.96-5.85), and IAT+RT (Emax = 3.49, 95% CrI: 1.26-5.79).</p><p><strong>Conclusions: </strong>The exercise dose-response relationship in heart failure follows an Emax curve, with distinct dose-benefit profiles across different exercise modalities. Based on the current evidence, the following preliminary considerations may be offered: for patients with limited exercise tolerance, MBT may be considered as one of the preferred options; for those with moderate exercise tolerance, IAT+RT or CAT+RT may be suitable choices; for patients with good exercise tolerance, IAT or RT may be considered; and for patients with comorbid obesity, CAT may be incorporated into a comprehensive management program.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149243732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial Screening with an Integrated Consultation Pathway for Cardiology Inpatients: A Randomised.","authors":"Stephan Christoph Feder, Zuhal Simsek, Joe J Simon, Mechthild Hartmann, Bastian Bruns, Till Johannes Bugaj, Jonas Hoch, Martin Dugas, Hans-Christoph Friederich","doi":"10.1093/eurjpc/zwag561","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag561","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149264688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Statin cascade of care in people with HIV: current gaps in primary and secondary prevention.","authors":"Rebecka Papaioannu Borjesson, Nicolò Capra, Riccardo Lolatto, Camilla Muccini, Golnaz Torkjazi, Silvia Nozza, Diana Canetti, Tommaso Clemente, Elena Bruzzesi, Hamid Hasson, Antonella Castagna, Vincenzo Spagnuolo","doi":"10.1093/eurjpc/zwag566","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag566","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149243730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-grade inflammation and cardiovascular events among patients with chronic kidney disease.","authors":"Justina Motiejunaite, Leïla Benamara, Emilie Moutard, Jean-Michel Halimi, Natalia Alencar de Pinho, Nicolas Danchin, Victor Aboyans, Ziad A Massy","doi":"10.1093/eurjpc/zwag538","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag538","url":null,"abstract":"<p><strong>Aims: </strong>Chronic inflammation is associated with cardiovascular disease in the general population, but data on patients with chronic kidney disease (CKD) are limited. We sought to assess whether systemic low-grade inflammation is independently associated with cardiovascular events in CKD patients not yet on kidney replacement therapy, with or without a history of atherosclerotic cardiovascular disease (ASCVD).</p><p><strong>Methods: </strong>CKD-REIN is a prospective cohort study of adults with CKD stages 2-5, conducted in 40 French nephrology outpatient facilities. Baseline high-sensitivity plasma C-reactive protein (hs-CRP) was centrally measured using an immunoturbidimetric method. Systemic low-grade inflammation was defined as hs-CRP ≥2 mg/L. Cox proportional hazards models estimated cause-specific hazard ratios (HR) and 95% confidence intervals (CI) for major adverse cardiovascular events (MACE; composite of stroke, myocardial infarction, or cardiovascular death) or hospitalization for heart failure (HHF).</p><p><strong>Results: </strong>We included 2078 patients: 67% men, mean (SD) age 67(13) years, mean eGFR 36(12) mL/min/1.73 m2, 38% with history of ASCVD, median hs-CRP concentration 2.4 mg/L (inter-quartile range 1.1-5.1). After median follow-up of 5 years, 171 patients had a MACE and 207 had HHF. After controlling for potential confounders, a twofold increase in hs-CRP was associated with a 12% (95% CI 0-26) higher cause-specific hazard of MACE and a 26% (95% CI 13-40) higher cause-specific hazard of HHF.</p><p><strong>Conclusion: </strong>In CKD patients not yet on kidney replacement therapy, systemic low-grade inflammation, measured through hs-CRP, is associated with occurrence of cardiovascular events independently of traditional risk factors, including a history of ASCVD.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149237439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of digital health interventions for care integration in coronary artery disease: a systematic review and meta-analysis.","authors":"Allegra Chan, Hooi Min Lim, Woei Xian Lim, Jia Ting Leong, Adina Abdullah, Adam G Dunn","doi":"10.1093/eurjpc/zwag552","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag552","url":null,"abstract":"<p><strong>Aim: </strong>To assess the effectiveness of digital health interventions (DHIs) supporting care integration for coronary artery disease (CAD) in improving health outcomes compared to usual care.</p><p><strong>Methods: </strong>For this systematic review, we searched MEDLINE, CINAHL, EBSCO Psychology and Behavioural Sciences Collection, Scopus, and Web of Science from 1 January 1995 to 5 November 2025. We included studies reporting primary data on DHIs supporting care integration for patients with CAD. Primary endpoints were all-cause mortality and readmissions, and CVD events. Secondary endpoints were the control of cardiovascular risk factors. We conducted random-effects meta-analyses in RevMan and assessed risk of bias with Cochrane's RoB tools.</p><p><strong>Results: </strong>We included 72 studies (23,111 participants), assessing 45 in the meta-analysis. All DHIs supported person-centred care integration (n=72) while few DHIs addressed clinical care integration (n=22), professional integration (n=12) and functional integration (n=22). Compared to usual care, DHIs supporting care integration had significant reductions in the odds of CVD events (OR: 0.74 [0.59, 0.92], df=5, p=0.02), but not in all-cause mortality or readmissions.</p><p><strong>Conclusions: </strong>Although this review shows that DHIs supporting care integration were associated with reduced CVD events compared to usual care, the current evidence remains concentrated primarily on person-centred care integration, with limited studies evaluating broader dimensions of care integration at organisational and systemic levels. These findings highlight the important evidence gaps of DHIs in supporting more comprehensive and system-level integration in cardiovascular care. Further research is necessary to understand the influence of DHI modality and function on effectiveness of care integration.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149237423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Where you draw the line: ancestry-specific adiposity thresholds determine measured Asian representation in obesity trials.","authors":"Eugene Yang, Pranav Mellacheruvu, Lina Yimeng Du, James Floyd, Daniel Seung Kim","doi":"10.1093/eurjpc/zwag554","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag554","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149237421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the \"Pathobiological Determinants of Atherosclerosis in Youth Risk Score\" in a Norwegian Cohort of Young Adults.","authors":"Benedikte Lutterbey, Eirik Aaseth, Sigrun Halvorsen, Jørgen Gravning","doi":"10.1093/eurjpc/zwag556","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag556","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149237428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Greenspace visitation and risk of major adverse cardiovascular events: evidence from the Houston methodist cardiovascular learning health system registry.","authors":"Weichuan Dong, Sarayu Chandra Mouli, Izza Shahid, Rakesh Gullapelli, Budhaditya Bose, Tong Zhang, Jad Ardakani, Juan C Nicolas, Zulqarnain Javed, Kai Zhang, Zhuo Chen, Sanjay Rajagopalan, Jay Maddock, Khurram Nasir, Sadeer Al-Kindi","doi":"10.1093/eurjpc/zwag470","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag470","url":null,"abstract":"<p><strong>Aims: </strong>To evaluate whether mobility-derived greenspace visitation, as a behavioural measure of environmental exposure, is associated with major adverse cardiovascular events (MACE) independent of individual and neighbourhood factors.</p><p><strong>Methods and results: </strong>We conducted a retrospective cohort study of adults in the Houston Methodist Cardiovascular Disease Learning Health System Registry (2016-2023). Greenspace visitation was defined at the census-tract level using mobility-derived foot-traffic data and modelled as annual visits per resident device. The primary outcome was incident MACE (myocardial infarction, stroke, coronary revascularization, and all-cause mortality). The Cox models, restricted cubic splines, and Kaplan-Meier curves assessed associations with sequential adjustment for demographics, comorbidities, smoking, and neighbourhood social vulnerability. Among 1 088 866 adults without baseline atherosclerotic cardiovascular disease, median (SD) age was 49 (17.6) years, and 59.9% were female. Greenspace visitation varied across neighbourhoods and by demographic and socioeconomic characteristics. Each additional 10 annual visits was associated with lower MACE risk in unadjusted models [hazard ratio (HR) 0.82; 95% confidence interval (CI): 0.81-0.83] and after adjustment for demographics, comorbidities, and smoking (HR 0.89; 95% CI: 0.88-0.91). A non-linear relationship showed risk reductions at low-to-moderate visitation, plateauing at 10-15 visits annually. After adjusting for social vulnerability, associations were attenuated and no longer significant. The Kaplan-Meier curves showed higher event-free survival in high-visitation areas, consistent across MACE components.</p><p><strong>Conclusion: </strong>Mobility-derived greenspace visitation is associated with lower cardiovascular risk. These findings highlight greenspace engagement as a potentially modifiable behavioural exposure and support strategies to enhance access and utilization of greenspaces for cardiovascular prevention.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temperature-Attributable Cardiovascular Mortality in Europe Under Future Climate Scenarios: Projected Impacts of Population Aging and Climate Change to 2080.","authors":"Gokul Parameswaran, Sai Rahul Ponnana, Santosh K Sirasapalli, Feriel Presswalla, Niketh Surya, Tong Zhang, Zhuo Chen, Jean-Eudes Dazard, Weebearb J Requia, Mark Nieuwenhuijsen, Thomas Münzel, Salil V Deo, Sanjay Rajagopalan","doi":"10.1093/eurjpc/zwag533","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag533","url":null,"abstract":"<p><strong>Aims: </strong>Heat and cold stress are established cardiovascular risk factors. As climate patterns shift and Europe's population ages, quantifying their separate attributable fractions-and projecting future temperature-attributable cardiovascular disease (tCVD) burden-is essential for clinical and policy decision-making.</p><p><strong>Methods: </strong>Europe was divided into a 0.25° × 0.25° grid (12,411 land cells across 37 countries). Annual cardiovascular disease (CVD) deaths (2016-2023) were downscaled from national estimates using population data. Temperature-mortality relative risk coefficients were drawn from a 27-country pooled study and applied via population attributable fractions with 1,000 Monte Carlo simulations. Daily mean temperature projections from five bias-corrected climate models were obtained under moderate (SSP2-4.5) and high (SSP5-8.5) emission scenarios. Population aging was incorporated using country-level age projections; climate-only analyses held age structure constant at 2020 levels.</p><p><strong>Results: </strong>At baseline, non-optimal temperature accounted for 168,586 [144,961-192,293] CVD deaths annually (31.4 [27.0-35.8] per 100,000), with a cold-to-heat ratio of 5:1. Under SSP5-8.5, total tCVD mortality is projected to nearly double to 62.4 [48.5-76.2] per 100,000 by late-century (441,772 [343,627-540,116] annual deaths), with heat-attributable rates projected to rise 472%. Population aging may amplify total projected mortality by over 80% by late century beyond climate change alone; without aging, cold-attributable rates may decline over the century rather than rise.</p><p><strong>Conclusions: </strong>tCVD mortality across Europe is projected to double by late-century, driven by dramatic heat increases and substantially amplified by population aging. These findings support greater integration of temperature-related CVD risk into clinical practice and public health policy.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical reflections on the non-Lp(a) apoB/Lp(a) ratio.","authors":"Antonio Meseguer-Hernández, Francisco Buendía-Santiago, José Manuel Andreu-Cayuelas","doi":"10.1093/eurjpc/zwag549","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag549","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149220179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}