Bastian Schrader, Armin Weers, Burkhard Garmann, Stephan Lüders, Matteo Scorcelletti, Bernhard Vaske, Paul Meyer, Eugen Gehlenborg, Sandra Garstecki, Joachim Schrader, Albrecht Elsässer
{"title":"Football as the champion of cardiovascular prevention: results of the randomized and interventional MY-3F study (Fit & Fun with Football after myocardial infarction or coronary artery disease).","authors":"Bastian Schrader, Armin Weers, Burkhard Garmann, Stephan Lüders, Matteo Scorcelletti, Bernhard Vaske, Paul Meyer, Eugen Gehlenborg, Sandra Garstecki, Joachim Schrader, Albrecht Elsässer","doi":"10.1093/eurjpc/zwaf273","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf273","url":null,"abstract":"<p><strong>Aims: </strong>The MY-3F [Fit & Fun with Football after myocardial infarction (MI) or coronary artery disease (CAD)] study was the first to investigate whether a structured and health-adapted football training programme can improve fitness and risk factors in patients with CAD and whether it is safe. The primary objective of this study was to improve fitness in maximum oxygen uptake in spiroergometry (VO2peak), blood pressure, weight, and safety.</p><p><strong>Methods and results: </strong>The MY-3F study is a prospective randomized interventional study with 1-year follow-up in patients with MI or CAD. A football group (FG, n = 89) completed a structured 'health' football training (1 h/week, 75 min) led by licensed football coaches. The results were compared with a control group (CG, n = 88). VO2peak in the FG significantly increased from 18.0 to 19.7 mL/min/kg (P < 0.001), and VO2peak in the CG significantly decreased from 19.5 to 18.3 mL/min/kg (P = 0.046). In the FG, running performance per participant per training improved from 1.8 km at admission to 2.4 km at the end of study (P < 0.001). In the FG, blood pressure decreased from 132/81 to 125/76 mmHg (P < 0.001). In the CG, it changed slightly from 137/82 to 136/82 mmHg (ns). In addition, a significantly more antihypertensives were given in CG, but not in FB. In the FG, weight decreased from 92.3 to 90.4 kg (P = 0.003). In the CG, it increased slightly from 90.7 to 91 kg (P = 0.6 ns). Depressive symptoms showed a significant improvement in the FG (P = 0.034), but no changes were observed in the CG. There was no significant change in LDL cholesterol in both groups, but significantly more lipid-lowering therapy was administered in the CG (P = 0.049).</p><p><strong>Conclusion: </strong>In My-3F, the preventive benefit on CVRF (cardiovascular risk factors) and fitness of football training in patients after MI or CAD was clearly demonstrated for the first time. The concept proved to be safe and cost-effective and could open the doors of football clubs to evidence-based cardiological prevention.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Childhood Exposure to Multiple Types of Violence and Adult Cardiovascular Disease.","authors":"Cancan Cui, Lin Liu, Zheng Guo, Jiayin Song, Yulu Zheng, Zhenming Zhang, Ning Han, Yitian Qi, Yuanmei Chen, Chunyan Wang, Chen Sheng, Lois Balmer, Zhijia Wang, LinLin Liu, Zhiyuan Wu","doi":"10.1093/eurjpc/zwaf292","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf292","url":null,"abstract":"<p><strong>Aims: </strong>To explore the associations between childhood experience of violence from parents, siblings, and peers and the subsequent risk of cardiovascular disease (CVD) and to examine whether adult depressive symptoms modify these associations.</p><p><strong>Methods and results: </strong>This population-based cohort study used data from the China Health and Retirement Longitudinal Study (CHARLS). Childhood exposures to violence from parents, siblings, and peers were assessed through a life history questionnaire. Depressive symptoms were measured using the validated 10-item Center for Epidemiologic Studies Depression Scale. The primary outcome was self-reported, physician-diagnosed CVD. Multivariate Cox proportional hazards models with age as the time scale were used. The study included 11,398 participants, with a mean (SD) age of 58 (9) years, of whom 5622 (49.3%) were men. Among participants, 1101 (9.7%) reported frequent childhood violence exposure, including violence from parents (623, 5.5%), siblings (117, 1.0%), and peers (515, 4.5%). Frequent exposures to violence from parents, siblings, peers, or any type were associated with increased risks of CVD, with hazard ratios (HRs) of 1.23 (95% CI: 1.04-1.45), 1.24 (0.87-1.75), 1.25 (1.05-1.49), and 1.22 (1.06-1.40), respectively. The associations were consistent across subgroups and multiple sensitivity analyses. Adult depressive symptoms mediated 23.0% of the association between frequent exposure to violence and CVD (P for mediation = 0.03).</p><p><strong>Conclusion: </strong>Childhood exposure to violence from parents, siblings, and peers is associated with an elevated risk of adult-onset CVD. Addressing mental health may help mitigate the long-term CVD risk linked to childhood violence exposure.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sarcopenia : a new cardiovascular risk factor ?","authors":"Olivier Hanon","doi":"10.1093/eurjpc/zwaf282","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf282","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reply to \"Oral Formulation and SGLT2i Interaction: Key Nuances in Semaglutide's Effect on Atrial Fibrillation\".","authors":"Arturo Cesaro, Vincenzo Acerbo, Paolo Calabrò","doi":"10.1093/eurjpc/zwaf298","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf298","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144093250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bradley Tucker, William J Tucker, Ji Soo Chung, Gemma A Figtree, Anthony Keech, Sanjay Patel
{"title":"The efficacy and safety of low dose colchicine in atherosclerotic cardiovascular disease - A systematic review and meta-analysis.","authors":"Bradley Tucker, William J Tucker, Ji Soo Chung, Gemma A Figtree, Anthony Keech, Sanjay Patel","doi":"10.1093/eurjpc/zwaf302","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf302","url":null,"abstract":"<p><strong>Aim: </strong>Colchicine has recently been approved for the treatment of atherosclerotic cardiovascular disease (ASCVD). Since then, three large trials of colchicine in ASCVD have failed to reach their primary endpoints.</p><p><strong>Method: </strong>A systematic search of PubMed, Embase and Cochrane Central Register of Controlled Trials was performed (PROSPERO registration: CRD42024616378). The primary endpoint of major adverse cardiovascular events (MACE) was defined as a composite of myocardial infarction, stroke and cardiovascular death. The key secondary endpoint of extended MACE (eMACE) was defined as MACE plus coronary revascularisation. Pooled estimates were calculated using a random-effects model and are presented as risk ratio (95% confidence interval).</p><p><strong>Results: </strong>1624 articles were screened. 12 met inclusion criteria, yet one trial reported zero endpoint events in both arms. As such, 11 trials were included in the meta-analysis, with a total of 1983 primary endpoint events across 30,808 participants. Colchicine was associated with a 17% reduction in the incidence of MACE (0.83 [0.73, 0.95]; p=0.006) and 23% reduction in the incidence of eMACE (0.77 [0.63, 0.94]; p=0.01). This reduction was driven by a lower rate of myocardial infarction (0.78 [0.63, 0.95]; p=0.02) and coronary revascularisation (0.73 [0.55, 0.97]; p=0.03). There were also numerically fewer strokes in the colchicine treated population (0.81 [0.63, 1.04]; p=0.11). Colchicine had no effect on cardiovascular (0.96 [0.79, 1.15]; p=0.64) or non-cardiovascular mortality (1.04 [0.76, 1.41]; p=0.81).</p><p><strong>Conclusion: </strong>Colchicine reduces the risk of non-fatal ischaemic events in patients with ASCVD. Further studies are required to identify a population(s) who stands to benefit most from this promising therapy.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Depression and Cardiovascular risk assessment: a multi-layered issue of equity and need?","authors":"Caroline A Jackson","doi":"10.1093/eurjpc/zwaf303","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf303","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marcel Ballin, Anna Nordström, Peter Nordström, Viktor Hugo Ahlqvist
{"title":"Cardiorespiratory fitness in adolescence and premature mortality: widespread bias identified using negative control outcomes and sibling comparisons.","authors":"Marcel Ballin, Anna Nordström, Peter Nordström, Viktor Hugo Ahlqvist","doi":"10.1093/eurjpc/zwaf267","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf267","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Eva Soler-Espejo, María Pilar Ramos-Bratos, Eduardo González-Lozano, Gregory Y H Lip, Francisco Marín, José Miguel Rivera-Caravaca, Vanessa Roldán
{"title":"Association between baseline adherence to a healthy lifestyle with ischemic and major cardiovascular events in patients with atrial fibrillation.","authors":"Eva Soler-Espejo, María Pilar Ramos-Bratos, Eduardo González-Lozano, Gregory Y H Lip, Francisco Marín, José Miguel Rivera-Caravaca, Vanessa Roldán","doi":"10.1093/eurjpc/zwaf287","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf287","url":null,"abstract":"<p><strong>Aims: </strong>Managing modifiable risk factors and adherence to a healthy lifestyle are key in the holistic integrated care management of atrial fibrillation (AF). This study examines the relationship between a baseline healthy lifestyle and adverse clinical outcomes in AF patients.</p><p><strong>Methods: </strong>We included AF patients starting oral anticoagulation (OAC) between January 2016 and November 2021. Adherence to a healthy lifestyle was assessed at baseline using five modifiable lifestyle factors and patients were categorized into three groups based on points of adherence to modifiable factors: poor (0-8 points); moderate (9-12 points); high (13-17 points). The primary outcome was a composite of ischemic events, over a 2-years follow-up.</p><p><strong>Results: </strong>3,266 AF patients were included (median age 77 [IQR 70-83] years), 52.8% female), and of these, 906 (27.7%) had high adherence. Incidence rate ratios were significantly lower in both the moderate adherence group (0.61; 95% CI 0.46-0.80) and the high adherence group (0.59; 95% CI 0.42-0.81) compared to the poor adherence group. Cox regression analyses adjusted for OAC type showed that high adherence to a healthy lifestyle significantly reduced the risk of composite ischemic events (aHR 0.58; 95% CI 0.42-0.79; p<0.001). After adjusting for additional risk factors, high adherence remained associated with lower risk of ischemic events (aHR 0.59; 95% CI 0.42-0.81; p=0.001). Similar results were observed for the secondary endpoints of MACE and ischemic stroke/TIA/systemic embolism; and in competing risk regression analyses.</p><p><strong>Conclusion: </strong>High baseline adherence to a healthy lifestyle reduced the risk of ischemic and major cardiovascular events in AF patients.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A whisper from the endothelium: Can we hear it?","authors":"Martin Bahls, Nicolle Kränkel","doi":"10.1093/eurjpc/zwaf299","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf299","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison between the 6-minute walking test and gait speed during outpatient cardiac rehabilitation.","authors":"Duccio Rossini, Elio Venturini, Massimo Piepoli","doi":"10.1093/eurjpc/zwaf284","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf284","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}