European journal of preventive cardiology最新文献

{"title":"Looking through the smoke screen: reviewing the risks of occasional smoking.","authors":"Priyanka Satish, Daniel Thomas, Marianne Zeller","doi":"10.1093/eurjpc/zwaf243","DOIUrl":"10.1093/eurjpc/zwaf243","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":"2734-2735"},"PeriodicalIF":10.0,"publicationDate":"2026-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular and metabolic acute effects of heated tobacco products in healthy smokers.","authors":"Lea Strohm, Dominika Mihaliková, Alexander Czarnowski, Patrick Dittmann, Dominik Gillenkirch, Omar Hahad, Michael Molitor, Marin Kuntic, Philipp Lurz, Thomas Münzel, Andreas Daiber, Paul Stamm","doi":"10.1093/eurjpc/zwag524","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag524","url":null,"abstract":"<p><strong>Aims: </strong>Heated tobacco products (HTPs) are increasingly promoted as 'reduced-harm' alternatives to combustible cigarettes, despite delivering pharmacologically active nicotine and complex aerosols. Independent human data on their acute cardiovascular effects remain limited.</p><p><strong>Methods and results: </strong>In this investigator-initiated, within-subject pre-post study, healthy adult smokers were supervised in their exposure to two consecutive HTP sticks (IQOS). Endothelial function was assessed by brachial artery flow-mediated dilation (FMD), along with haemodynamic parameters, venous blood gas and metabolic markers, and oxidative DNA damage measured by the comet assay. Acute HTP exposure resulted in a significant reduction in FMD, indicating rapid endothelial dysfunction. This was accompanied by an increase in systolic blood pressure, reductions in venous oxygen tension and saturation, and an increase in venous carbon dioxide, consistent with impaired tissue oxygenation. Methaemoglobin levels increased, reflecting oxidative modification of haemoglobin, while metabolic alterations in glucose and lactate suggested nicotine-mediated sympathetic and metabolic stress. Importantly, short-term HTP use induced significant oxidative DNA damage in peripheral blood cells. These effects occurred after a single, real-world exposure in otherwise healthy smokers.</p><p><strong>Conclusion: </strong>Together, these findings demonstrate that HTPs are not biologically inert and that acute exposure is sufficient to trigger vascular dysfunction, systemic metabolic disturbance, and genotoxic stress. The results challenge claims of cardiovascular harm reduction and underscore that all nicotine-containing products remain relevant targets for cardiovascular prevention and regulation.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149264717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remote Blood Pressure Monitoring for Post-Acute Care and Secondary Prevention After Aortic Dissection.","authors":"Sina Martha Maria Lagache, Maani Hakimi, Renate Schoenenberger-Berzins, Nicolas Attigah, Franz H Messerli, Georg Jung","doi":"10.1093/eurjpc/zwag557","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag557","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149264696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Climate change and cardiovascular risk factors management: emerging challenges and strategies for prevention and adaptation.","authors":"","doi":"10.1093/eurjpc/zwag559","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag559","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149285951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining Cardiometabolic Disease: Expert Consensus on the CardioVascular-Kidney-Liver-Metabolic (CVKLM) Multiorgan Staging.","authors":"Guillaume Baudry, Jan Biegus, Juan Carlos López-Azor, Biykem Bozkurt, Javed Butler, Marta Cobo-Marcos, Jeroen Dauw, Sven Francque, Nicolas Girerd, Jennifer B Green, Mateusz Guzik, Gracjan Iwanek, Masatake Kobayashi, Peder Langeland Myhre, Marco Metra, Òscar Miró, Wilfried Mullens, Alberto Palazzuoli, Piotr Ponikowski, Claudio Ronco, Patrick Rossignol, Arun Sanyal, Carmine Zoccali, Muthiah Vaduganathan, Harriette G C Van Spall, Faiez Zannad","doi":"10.1093/eurjpc/zwag563","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag563","url":null,"abstract":"<p><p>Cardiometabolic diseases increasingly manifest as interconnected dysfunction across the heart, vasculature, kidneys, liver, and metabolic system. The global rise in obesity, insulin resistance, and diabetes, together with therapies benefiting multiple organs, has reshaped the epidemiology and understanding of cardiometabolic disease, exposing the limitations of organ-specific or single-stage approaches. The cardioVascular-kidney-liver-metabolic (CVKLM) framework is a multidimensional staging system in which cardiac, vascular, kidney, liver, and metabolic involvement are graded independently from absent to advanced. Analogous to tumour-node-metastasis staging, it provides a standardized language describing disease severity within each organ and its distribution across organs. Rather than replacing existing classifications, CVKLM integrates universal heart failure stages, validated vascular risk assessment, KDIGO chronic kidney disease stratification, contemporary metabolic dysfunction-associated steatotic liver disease (MASLD) and advanced liver disease criteria, and current definitions of diabetes and clinical obesity. Unlike hierarchical frameworks assigning a single overall stage, CVKLM preserves organ-specific information and records coexisting abnormalities across domains. Intended for clinical and research phenotyping and staging rather than as a validated global risk score, it may facilitate systematic recognition of concomitant organ disease, support existing organ-specific diagnostic, referral, and treatment pathways, and provide a standardized taxonomy for observational studies and clinical trials. The prognostic significance of CVKLM profiles, their incremental value beyond established risk tools, and their clinical utility remain to be established. By integrating these domains within a common architecture, CVKLM offers a pragmatic framework spanning the full spectrum of cardiometabolic disease, from preclinical involvement to advanced multiorgan failure.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149285970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Digital Commitment Devices in Improving Lifestyle and Cardiometabolic Outcomes in Adults with Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis.","authors":"Ri Jie Chen, Chloe Si Pei Goh, Nicholas Ws Chew, Han Shi Jocelyn Chew","doi":"10.1093/eurjpc/zwag534","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag534","url":null,"abstract":"<p><strong>Aim: </strong>Lifestyle modification is crucial for cardiovascular disease prevention but remains challenging due to complex behavioural factors such as the intention-behaviour gap. Digital commitment devices (DCD) could narrow this gap by leveraging behavioural economics, but its effectiveness remains unclear. Therefore, this review aims to evaluate the effects of DCDs on lifestyle and cardiometabolic outcomes in adults with elevated cardiometabolic risk.</p><p><strong>Methods: </strong>A systematic search of 12 electronic databases was conducted from database inception to August 2025. Study selection and methodological quality appraisal using the Cochrane Risk of Bias 2.0 tool were performed independently by two reviewers. Where appropriate, effect sizes were pooled using random effects meta-analyses. The certainty of evidence for meta-analysed outcomes was assessed using the GRADE approach.</p><p><strong>Results: </strong>A total of 7,378 articles were retrieved, of which 29 randomised controlled trials involving 7,534 participants were included. DCDs were found to significantly increase daily step count (WMD=664.87, 95% CI: 463.22 to 866.51, T=6.88, p<0.00001; I2=0%) and weight loss (WMD=-1.90kg, 95% CI: -2.59 to -1.21, p<0.0001; I2=70%), improve self-reported emotional (WMD=-1.34, 95% CI: -2.59 to -0.09, p=0.04; I2=0%) and uncontrolled eating (WMD=-1.74, 95% CI: -3.05 to -0.43, p=0.02; I2=0%) behaviours, body fat percentage, diet and medication adherence.</p><p><strong>Conclusion: </strong>DCDs could improve lifestyle and cardiometabolic outcomes by improving physical activity and weight management, thus enhancing cardiometabolic disease prevention. Future research should prioritise long-term trials with extended follow-up periods beyond 12 months to observe physiological improvements and assess maintenance of effects.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149264754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to Clinical reflections on the non-Lp(a) apoB/Lp(a) ratio.","authors":"Sotirios Tsimikas, Gregg W Stone, David Erlinge","doi":"10.1093/eurjpc/zwag564","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag564","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149264725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using rare coding variants in SLC5A2 to explore the impact of SGLT2 inhibitors on cardiorenal outcomes.","authors":"Siqi Wang, Ilja M Nolte, Dion Groothof, Hailun Qin, Stephan J L Bakker, Pim van der Harst, Harold Snieder","doi":"10.1093/eurjpc/zwag539","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag539","url":null,"abstract":"<p><strong>Aims: </strong>Sodium-glucose cotransporter-2 (SGLT2) inhibitors are agents originally developed as glucose-lowering drugs but now widely used to improve cardiorenal outcomes, including in patients with heart failure and chronic kidney disease regardless of diabetes status. However, their exact mode of action remains unclear. Here, we investigated the association of loss-of-function (LoF) and other rare coding variants in the SLC5A2 gene, as a genetic model of altered SGLT2 function, with 13 cardiometabolic and renal traits and clinical outcomes.</p><p><strong>Methods and results: </strong>A total of 442 570 European ancestry participants from the UK Biobank with exome sequence and phenotype data were included. We applied SAIGE-GENE+ for gene-based and single-variant association tests in the full study population and in individuals with heart failure, renal failure, and type 2 diabetes (T2D). A total of 52 LoF variants in SLC5A2 were identified. Rare variants in SLC5A2 were associated with decreased uric acid (PCauchy = 4.98 × 10-13) and with increased haematocrit (PCauchy = 1.67 × 10-5), haemoglobin (PCauchy = 1.60 × 10-5), and estimated glomerular filtration rate (PCauchy = 9.88 × 10-4). One frameshift variant (rs267607067) was significantly associated with increased haemoglobin (β = 0.33 [95% CI 0.15-0.51]; P-value = 2.40 × 10-4) and another (rs768095044) with decreased uric acid (β = -0.31 [95% CI -0.49 to -0.13]; P-value = 4.22 × 10-4). In patients with T2D, the rare variants within SLC5A2 were also associated with a lower probability of having heart failure (PCauchy = 4.00 × 10-4).</p><p><strong>Conclusion: </strong>Rare genetic variants in SLC5A2 were associated with increased haemoglobin and decreased uric acid. These variants were also associated with a lower probability of heart failure among participants with T2D, providing tentative genetic support for a cardioprotective effect of SGLT2 inhibition.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149264709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking Patient Selection for Colchicine: Beyond Residual Inflammation.","authors":"Rhea Machado, Jeet Upadhyay, Aditya Bhat, Nitesh Nerlekar, Nick S Nurmohamed, Shaun Khanna","doi":"10.1093/eurjpc/zwag555","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag555","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149264765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classifying lipid lowering intensity in the era of combination therapy: A proposal to define very high intensity regimens.","authors":"Nelson Wang, Kausik K Ray, Sophia Zoungas, Otavio Berwanger, Stephen Nicholls, Anthony Rodgers","doi":"10.1093/eurjpc/zwag565","DOIUrl":"https://doi.org/10.1093/eurjpc/zwag565","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":10.0,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149264704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}