European journal of preventive cardiology最新文献

{"title":"Integrating Ketone Bodies in Multi-Marker Risk Prediction of Incident Heart Failure in the Multi-Ethnic Study of Atherosclerosis (MESA).","authors":"Parag Anilkumar Chevli, Senthil Selvaraj, Byron C Jaeger, Aziz Hammoud, Margery A Connelly, Christopher deFilippi, Joao A C Lima, Sadiya S Khan, David M Herrington, Michael D Shapiro, Muthiah Vaduganathan","doi":"10.1093/eurjpc/zwaf168","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf168","url":null,"abstract":"<p><strong>Aims: </strong>Circulating ketone bodies (KB) have emerged as a potential adjunctive biomarker for incident heart failure (HF) risk and might provide incremental information beyond established biomarkers. A multi-marker risk score may improve risk stratification of incident HF in the community. The authors aim to develop a risk score using N-terminal proB-type natriuretic peptide (NT-proBNP) and high-sensitivity troponin (hs-cTnT) and a unique systemic biomarker of KB to predict HF among participants without cardiovascular disease.</p><p><strong>Methods: </strong>A multi-marker score was developed incorporating NT-proBNP ≥ 125 pg/mL, hs-cTnT ≥ 14 ng/L, and total KB ≥ 75th percentile (316 μmol/L), with 1 point allocated for each abnormal marker among Multi-Ethnic Study of Atherosclerosis (MESA) participants. Multivariable Cox model was used to assess the association between multi-marker risk score and the risk of incident HF.</p><p><strong>Results: </strong>Among 6,748 participants, there were 383 incident HF events over a median follow-up of 15.7 years. The three biomarkers exhibited poor correlation with one another (r<0.06 for all). The addition of KB to NT-proBNP and hs-cTnT to identify incident HF improved 5- and 10-year risk prediction (C-statistic 0.74 vs. 0.77, p=0.02 and 0.70 vs. 0.73, p=0.02 respectively). There was no evidence of miscalibration using the multi-marker score for predicting 5- and 10-year HF risk (p>0.05). A graded association was observed between the multi-marker score and risk of HF independent of established clinical factors.</p><p><strong>Conclusions: </strong>The addition of plasma KB to a clinical risk score using biomarkers of cardiac injury and stress may further improve the prediction of incident HF.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Let's CLEAR things up: who benefits from low-dose colchicine?","authors":"Niekbachsh Mohammadnia, Cornelis Kramers, Aysun Cetinyurek-Yavuz, Saloua El Messaoudi","doi":"10.1093/eurjpc/zwaf166","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf166","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-modal interventions outperform nutritional or exercise interventions alone in reversing metabolic syndrome: a systematic review and network meta-analysis.","authors":"Bernice S Chan, Doris S F Yu, Cathy W Y Wong, Polly W C Li","doi":"10.1093/eurjpc/zwaf167","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf167","url":null,"abstract":"<p><strong>Aims: </strong>This review aimed to evaluate the comparative effectiveness of primary prevention interventions targeting therapeutic lifestyle changes on metabolic syndrome reversal and cardiometabolic outcomes in adults (≥ 18 years) with metabolic syndrome.</p><p><strong>Methods: </strong>A systematic search was conducted in seven electronic databases from inception to 28 April 2023 to identify randomised controlled trials (RCTs) of primary prevention interventions combating metabolic syndrome. Bayesian network meta-analyses were conducted to evaluate comparative effectiveness of active intervention components.</p><p><strong>Results: </strong>Total of 98 eligible RCTs involving 12 813 participants were included. The individual interventions were categorised as nutritional or exercise interventions and their combinations as multi-modal interventions. The behavioural change strategies were categorised according to the sources of behaviour (i.e., capability, opportunity and motivation). Pairwise meta-analysis demonstrated that multi-modal interventions outperformed exercise interventions in reversing metabolic syndrome. Network meta-analyses revealed the differences in the optimal active intervention components across outcomes. The consumption of a diet promoting moderate macronutrient intake (caloric restriction, DASH and Mediterranean diets) combined with supervised aerobic exercise training or professional physical activity advice or counselling consistently yielded superior beneficial effects on metabolic syndrome, which was supported by a low certainty of evidence. Between-study differences in body weight and blood pressure were significantly explained by the use of behavioural change strategies.</p><p><strong>Conclusion: </strong>Combining a moderate macronutrient diet with aerobic exercise training or physical activity advice or counselling demonstrated superior beneficial effects on metabolic syndrome and its defining characteristics. These findings could provide healthcare professionals with critical guidance for implementing lifestyle interventions to manage metabolic syndrome.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing the Translational Integration of Lifestyle Medicine in Cardiovascular-Kidney-Metabolic Syndrome.","authors":"Zacharias Papadakis","doi":"10.1093/eurjpc/zwaf169","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf169","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of inpatient and outpatient cardiac rehabilitation on the 5-year prognosis in patients with acute myocardial infarction.","authors":"Yasunori Suematsu, Akira Minei, Yoko Sumita, Koshiro Kanaoka, Michikazu Nakai, Yoshihiro Miyamoto, Hisatomi Arima, Koshi Nakamura, Tomoyuki Takura, Kazunori Shimada, Hirokazu Shiraishi, Nagaharu Fukuma, Masataka Sata, Hideo Izawa, Yoshihiro Fukumoto, Shigeru Makita, Yusuke Ohya, Shin-Ichiro Miura","doi":"10.1093/eurjpc/zwaf070","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf070","url":null,"abstract":"<p><strong>Aims: </strong>Cardiac rehabilitation (CR) has been shown to improve the prognosis of patients with acute myocardial infarction (AMI). In Japan, the duration of hospitalization has shortened, resulting in a lower participation rate in CR among outpatients. Therefore, we evaluated the effects of CR, stratified into inpatient and outpatient phases, on the prognosis of patients with AMI in Japan.</p><p><strong>Methods and results: </strong>A multi-centre, retrospective, cohort study in which extracted 4411 AMI patients from 72 institutes throughout Japan who were identified from a Japanese Registry Of All cardiac and vascular Diseases (JROAD) in 2014 was performed. The JROAD is a database from Diagnosis Procedure Combination, and we additionally investigated the detailed information about severity, complications, treatment of AMI, the results of examinations, and the 5-year prognosis with respect to CR (JROAD-CR). The patients were divided into four groups, depending on their history of CR as inpatients and outpatients. The percentages of inpatients and outpatients who received CR were 66.1% (n = 2917) and 9.91% (n = 437), respectively. The groups in which only inpatients received CR [In(+)Out(-)] and in which both inpatients and outpatients received CR [In(+)Out(+)] showed significant reductions in composite major adverse cardiovascular events [In(+)Out(-) group; hazard ratio (HR): 0.751, 95% confidence interval (CI) (0.584-0.967) and In(+)Out(+) group; HR: 0.641, 95% CI (0.426-0.964)] and all-cause mortality [In(+)Out(-) group; HR: 0.720, 95% CI (0.546-0.950) and In(+)Out(+) group; HR: 0.575, 95% CI (0.338-0.977)].</p><p><strong>Conclusion: </strong>This JROAD-CR study revealed that even short periods of CR during hospitalization are important and continuing CR into the outpatient phase may further improve the prognosis of patients with AMI.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Common Cardiovascular Risk Factors in Aortic Valve Calcification in the Middle-aged General Population.","authors":"Anne Wang, Athena Adeli, David Kylhammar, Eva Swahn, Jan E Engvall, Lars Lind, Stefan Söderberg, Anders Blomberg, Gunnar Engström, Jonas Spaak, Henrik Löfmark, Carl Johan Östgren, Tomas Jernberg, Göran Bergström, Magnus Settergren, Bahira Shahim","doi":"10.1093/eurjpc/zwaf157","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf157","url":null,"abstract":"<p><strong>Aim: </strong>Aortic valve calcification (AVC) is an underlying pathophysiological mechanism for aortic stenosis which is common in the elderly, but less is known in younger individuals. The aim was to study the prevalence and associated characteristics of AVC in a middle-aged general population.</p><p><strong>Methods: </strong>Data were obtained from the Swedish CArdioPulmonary bioImage Study (SCAPIS) comprising 30,154 individuals 50 to 64 years from the general population recruited in Sweden between 2013-2018. AVC was assessed visually on computed tomography (CT) and categorized as evident or not. Population attributable risk proportion (PARP) was calculated for six modifiable risk factors (smoking, hypertension, hyperlipidemia, diabetes, BMI ≥median and kidney dysfunction [eGFR <60 ml/min/1.73 m2]).</p><p><strong>Results: </strong>In total, 29,221 individuals with CT images available were included (mean age 57.5 years, 51% female) and AVC was present in 2,053 (7%). The AVC prevalence increased with age (50-54 years: 3%; 55-59 years: 7%; 60-64 years: 11%). In analyses adjusted for age, sex, smoking and study site, male sex (OR 2.02, 95% CI 1.84-2.22), hyperlipidemia (1.88 [1.68-2.11]), hypertension (1.73 [1.57-1.91]), diabetes (1.66 [1.39-1.97]), kidney dysfunction (1.54 [1.10-2.11]), smoking (1.36 [1.24-1.50]), age (increment by one year) (1.12 [1.11-1.13]) and BMI (increment by one unit) (1.04 [1.03-1.05) were associated with AVC. The PARP of AVC associated with the six modifiable risk factors was 34.5% (95% CI 29.6-39.4).</p><p><strong>Conclusions: </strong>In this large, contemporary middle-aged general population, AVC was prevalent in as many as 7% and six cardiovascular risk factors contributed to one third of the prevalence of AVC.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between pain and incident arrhythmias in 422,654 individuals: evidence from the UK Biobank cohort.","authors":"Pei Qin, Barbara I Nicholl, Frederick K Ho, Peter Hanlon, Carlos A Celis-Morales, Jill P Pell","doi":"10.1093/eurjpc/zwaf153","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf153","url":null,"abstract":"<p><strong>Aims: </strong>Pain is associated with cardiovascular disease; however, its association with incident arrhythmias is unclear. We assessed associations between different pain characteristics (pain type, chronic pain, chronic widespread pain [chronic widespread pain], chronic musculoskeletal pain [chronic musculoskeletal pain], and number of chronic pain and chronic musculoskeletal pain sites) and incident cardiac arrhythmias, overall and by subtype.</p><p><strong>Methods: </strong>The study included 422,654 UK Biobank participants. Pain was ascertained via a touchscreen questionnaire. The outcomes were incident arrhythmias: all cardiac arrhythmias, atrial fibrillation (AF), other (non-AF) cardiac arrhythmias, bradyarrhythmias, and ventricular arrhythmias. Multivariable Cox-proportional regression was used to investigate the associations.</p><p><strong>Results: </strong>Over a mean (SD) follow-up of 13.19 (1.96) years, 36,860 (8.72%) participants developed arrhythmia. Compared with those without pain, those with chronic localized pain and chronic widespread pain had increased risk of all cardiac arrhythmias (hazard ratio [HR] 1.13, 95% confidence interval [CI], 1.10-1.17; 1.34, 1.19-1.51), AF (1.09, 1.05-1.14; 1.33, 1.15-1.55), and other cardiac arrhythmias (1.17, 1.12-1.22; 1.41, 1.20-1.66). There was evidence of a dose-relationship between number of chronic pain sites and risk of all cardiac arrhythmias, AF and bradyarrhythmias. Effect estimates were significantly larger among participants aged <60 years than those aged ≥60 years, and larger in women than men.</p><p><strong>Conclusions: </strong>Chronic pain was associated with cardiac arrhythmias. Whilst causation cannot be assumed in any observational study, there was evidence of both a temporal relationship and dose-relationship. These findings reinforce the need for pain management approaches that include a broad assessment of individuals' risk factors, wider health status, and appropriate vigilance for emerging conditions.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Cardiovascular risk factors among endurance masters athletes from Switzerland.","authors":"","doi":"10.1093/eurjpc/zwaf140","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf140","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Overview of Cardiac Rehabilitation following post-acute myocardial infarction in European Society of Cardiology member countries.","authors":"","doi":"10.1093/eurjpc/zwaf105","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf105","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased cancer incidence in patients with pre-existing heart failure: results from a French nationwide cohort study.","authors":"Mariana Mirabel, Camille Nevoret, Orianne Domengé, Corinne Emery, Rudolf A De Boer, Jean-Philippe Empana, Jean-Sébastien Hulot","doi":"10.1093/eurjpc/zwaf152","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf152","url":null,"abstract":"<p><strong>Background and aims: </strong>There is conflicting evidence as to whether patients with pre-existing heart failure (HF) are at increased risk of developing cancer, especially because of common risk factors. We aimed to assess the incidence of cancer in patients with pre-existing HF compared with patients without known HF.</p><p><strong>Methods: </strong>The French National Administrative Health Data System, containing all healthcare information for 99% of the French population, was used to identify adult patients with a first diagnosis of HF between 2010 and 2019 and without a history of cancer before HF diagnosis. HF patients were matched for sex and age to HF-free and cancer-free individuals (3:1 ratio).</p><p><strong>Results: </strong>We found 330,867 HF patients, and 992,601 matched controls (54.7% women, mean age 77.7±13.5 years). A first cancer was diagnosed in 28,151 (8.5%) HF patients over a mean follow-up of 4.3±2.8 years compared to 77,325 (7.8%) in the controls over 4.9±2.8 years of follow-up (unadjusted subdistribution HR, sHR: 1.12 [1.11-1.13], P<0.001). The higher risk of new cancer in HF patients remained after full adjustment for major comorbidities, age, sex, year of diagnosis, region of residence, tobacco use and alcohol consumption (adjusted sHR=1.06, [1.04-1.07]; P<0.0001). Overall, the calculated attributable risk of new cancer after HF was 16.5% (9.9-16.8%). This increased risk was observed for most solid malignancies (especially colorectal and lung cancer), and for multiple myeloma.</p><p><strong>Conclusions: </strong>Patients with a history of HF have a higher risk of developing cancer than the general population. Cancer screening strategies should be advocated in patients with HF.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}