European journal of preventive cardiology最新文献

{"title":"Sodium or Potassium, and Chloride or Bicarbonate: Which Combination is Worth Its Salt?","authors":"Ragavendra R Baliga, Harpreet Singh, Jagat Narula","doi":"10.1093/eurjpc/zwaf137","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf137","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward Improving Risk Prediction through Clustering Analysis.","authors":"Ricardo Henao, Michael Pencina","doi":"10.1093/eurjpc/zwaf164","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf164","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic impact of residual inflammatory and triglyceride risk in statin-treated patients with well-controlled LDL cholesterol and atherosclerotic cardiovascular disease.","authors":"Francesca Maria Di Muro, Birgit Vogel, Samantha Sartori, Benjamin Bay, Angelo Oliva, Yihan Feng, Prakash Krishnan, Joseph Sweeny, Mauro Gitto, Kenneth Smith, Pedro Moreno, Johny Nicolas, Parasuram Krishnamoorthy, Pier Pasquale Leone, Deepak L Bhatt, George Dangas, Annapoorna Kini, Samin K Sharma, Roxana Mehran","doi":"10.1093/eurjpc/zwaf112","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf112","url":null,"abstract":"<p><strong>Aims: </strong>Identifying alternative contributors to the residual risk of atherosclerotic cardiovascular disease (ASCVD) beyond LDL cholesterol (LDL-C) levels is crucial. We investigated the relative impact of triglycerides (TGs) and high-sensitivity C-reactive protein (hs-CRP) on outcomes in statin-treated patients with well-controlled LDL-C undergoing percutaneous coronary intervention (PCI) for established ASCVD.</p><p><strong>Methods and results: </strong>We included 9446 statin-treated patients with LDL-C < 70 mg/dL undergoing PCI between 2012 and 2022, stratified into four groups: (i) no residual risk (TG <150 mg/dL + hs-CRP <2 mg/L); (ii) residual TG risk (TG ≥150 mg/dL + hs-CRP <2 mg/L); (iii) residual inflammatory risk (TG <150 mg/dL + hs-CRP ≥2 mg/L); and (iv) residual TG and inflammatory risk (TG ≥150 mg/dL + hs-CRP ≥2 mg/L). The primary endpoint was major adverse cardiovascular events (MACE) at 1 year, consisting of all-cause mortality, myocardial infarction, or stroke. Cox regression analysis was performed, using the no residual risk group as a reference. Of the total population, 5339 (56.5%) had no residual risk, 555 (5.9%) presented residual TG risk, 3009 (31.9%) had residual inflammatory risk, and 543 (5.7%) exhibited residual combined risk. After multivariable adjustment, patients with residual inflammatory or combined risk showed a significantly higher hazard of MACE, mainly driven by all-cause mortality. No significant difference was observed between patients with residual TG risk and those with no residual risk.</p><p><strong>Conclusion: </strong>In statin-treated patients with well-controlled LDL-C undergoing PCI, residual inflammatory risk-alone or in combination with residual TG risk-was associated with a higher incidence of MACE, highlighting the need for targeted preventive strategies beyond LDL-C lowering.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A remote booster program to attenuate sedentary behaviour in patients with coronary artery disease: A Randomized Controlled Trial.","authors":"Sophie H Kroesen, Bram M A van Bakel, Marijn de Bruin, Martijn F Pisters, Francisco B Ortega, Maria T E Hopman, Dick H J Thijssen, Esmée A Bakker, Thijs M H Eijsvogels","doi":"10.1093/eurjpc/zwaf162","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf162","url":null,"abstract":"<p><strong>Aims: </strong>Sedentary time (ST) can be reduced in patients with coronary artery disease (CAD) during cardiac rehabilitation (CR), but most patients relapse to sedentarism within months. We examined the effectiveness of a 3-week remote booster intervention on ST changes in CAD patients.</p><p><strong>Methods: </strong>CAD patients who previously (2.0 [1.9-2.2] years) completed CR were included in this randomized controlled trial (1:1, stratified for gender). All participants received usual care, whereas booster participants additionally received a 3-week remote behavioral change intervention. The primary outcome was the change in accelerometer-derived ST from baseline to post-intervention and secondary outcomes included changes in sedentary behaviour and physical activity (PA) characteristics. A baseline constrained linear mixed-model on an intention-to-treat basis was used.</p><p><strong>Results: </strong>Participants (19% female, booster: n=21, control: n=21) were 69 [63-75] years old. Greater decreases in ST (-1.3 (95% confidence interval (CI): -2.0; -0.6) versus -0.1 (95% CI: -0.8; 0.6) h/day, p-interaction=0.012) and number of prolonged sedentary bouts (-1.1 (95% CI: -1.6; -0.6) versus 0.2 (95% CI: -0.3; 0.7) bouts/day, p-interaction<0.001) in combination with larger increases in light PA (+1.1 (95% CI: +0.5; +1.8) versus +0.2 (95% CI: -0.4; +0.8) h/day, p-interaction=0.030) were found for the booster versus control group. Changes in moderate-to-vigorous PA (p-interaction=0.13) and step count (p-interaction=0.18) did not differ between groups.</p><p><strong>Conclusion: </strong>The remote booster program effectively reduced ST and increased light PA in CAD patients. These findings highlight the potential to change physical (in)activity behaviour of patients beyond completion of traditional CR programs.</p><p><strong>Trial registration: </strong>NCT06038188 (Clinical Trials.gov).</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An LDL-cholesterol level above 3 mmol/L should be treated - A personal case report.","authors":"Gisle Langslet","doi":"10.1093/eurjpc/zwaf158","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf158","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular disease and stroke prevention educational-behavioural programs for culturally and/or linguistically diverse communities: a systematic review and meta-analysis.","authors":"Sabine M Allida, Adriana Angelucci, Scott William, Faisal Alanazi, Seana Gall, Caleb Ferguson","doi":"10.1093/eurjpc/zwaf145","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf145","url":null,"abstract":"<p><strong>Aims: </strong>To identify the types of cardiovascular disease (CVD) and stroke prevention educational-behavioural programs for people from culturally and/or linguistically diverse (CALD) backgrounds and investigate their effect on CVD risk factors and disease knowledge.</p><p><strong>Methods and results: </strong>Four electronic databases were searched from inception to September 2023. Mean difference (MD) and standardised MD was calculated using random-effects model, and heterogeneity was assessed using the I2 statistic. Studies that were not included in the meta-analysis were narratively described. The Cochrane Risk of Bias tool and Joana Briggs Institute Critical Appraisal checklist were used to assess the quality of the included studies. Sixteen studies originating from USA and UK (4 RCTs and 12 quasi-experimental pre-post studies) with n=2331 participants (mean age 57.2 years, 50% women) were included. The programs were multi-component, 15 of which were culturally adapted and 1 was co-designed. Most were delivered face-to-face in groups. In contrast to the results among the pre-post studies, the pooled analysis showed that educational-behavioural programs may have little to no effect on SBP (MD 1.18 mmHg, 95% CI -2.42-4.79) and HbA1c (MD -0.29%, 95% CI -0.89-0.32). The results for LDL cholesterol, BMI, physical activity and dietary intake were also mixed except for CVD or stroke knowledge which demonstrated statistically significant improvements after the intervention.</p><p><strong>Conclusion: </strong>The effect of educational-behavioural programs on CVD risk factors is inconclusive but may improve CVD or stroke knowledge. Co-designing programs underpinned by behaviour change theories/techniques with stakeholders and target CALD communities may enhance their potential impact. Future studies should use more rigorous study design i.e., RCTs, valid and reliable outcome measures to reduce inherent bias and strengthen the evidence base for the effectiveness of these programs.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: A Note on Base Rates and Applicability of Screeners of Psychological Disorder in Adults with Congenital Heart Disease.","authors":"Michael T M Finn, Cheryl Bos","doi":"10.1093/eurjpc/zwaf159","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf159","url":null,"abstract":"","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of cardiac rehabilitation on the severity of angina, health-related quality of life, and exercise capacity among adults living with microvascular angina: a systematic review and meta-analysis.","authors":"Joana Oliveira, Stephen Paul Hoole, Peter Hartley, Morag Farquhar, Christi Deaton, Faye Forsyth, Allie Welsh","doi":"10.1093/eurjpc/zwaf150","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf150","url":null,"abstract":"<p><strong>Aim: </strong>To evaluate the effect of exercise-based cardiac rehabilitation (CR) on the severity of angina, health-related quality of life (HRQoL), and exercise capacity in adults living with microvascular angina (MVA).</p><p><strong>Methods: </strong>14 online databases were searched to identify randomized controlled trials (RCTs) comparing adults with MVA receiving CR to those receiving a control intervention involving no exercise. Meta-analyses using random-effects models was used to calculate mean differences or standardized mean differences (SMD).</p><p><strong>Results: </strong>Of 15,873 reports identified, five studies (222 participants) were included. Risk of bias for all outcomes were judged as 'some concerns' or 'high'. Mean ages ranged from 51 to 64 years, and 97.3% were women. Meta-analysis of CR's effect on the severity of angina was not feasible due to limited data. Meta-analysis on HRQoL was conducted at the domain level of Short Form-36 questionnaire (2 RCTs; n=76) and on exercise capacity measured by peak VO2 (3 RCTs; n=101). The HRQoL outcome was classified as 'very low certainty', indicating very little confidence in the effect estimates. The meta-analysis on exercise capacity showed a clinically meaningful change in peak VO2 in favor of CR, with a 4.16mL/kg/min increase in peak VO2 (SMD of 1.06, 95% CI -0.7 to 2.19, very low certainty).</p><p><strong>Conclusions: </strong>CR may improve exercise capacity in patients living with MVA compared to controls, however the evidence is very uncertain. High-quality RCTs are needed to rigorously determine the impact of CR on the severity of angina, HRQoL, and exercise capacity in patients living with MVA.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of neighbourhood and environmental factors on the risk of incident cardiovascular disease: a systematic review and meta-analysis.","authors":"Jack R G Brown, Paris J Baptiste, Hajar Hajmohammadi, Ramesh Nadarajah, Chris P Gale, Jianhua Wu","doi":"10.1093/eurjpc/zwaf165","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf165","url":null,"abstract":"<p><strong>Aims: </strong>We aimed to study the association of five key neighbourhood exposures in large cohort studies and risk of incident cardiovascular disease (CVD).</p><p><strong>Methods: </strong>We conducted a systematic search of MEDLINE, The Cochrane Library, Web of Science, and Embase from database inception to 20th October 2024. Included studies reported both incident (first-time) CVD diagnosis and neighbourhood exposures across five domains: retail environment; health services; physical environment; pollution; and neighbourhood deprivation. A random-effects meta-analysis was performed to estimate pooled risk of CVD across domains.</p><p><strong>Results: </strong>Of 39 studies included in the systematic review, 28 qualified for meta-analysis representing over 41 million people. The most frequently examined exposures were air pollution (n=17), followed by noise pollution (n=9), socioeconomic (n=6), green and blue spaces (n=3), and health and retail environments (n=4). Higher concentrations of particulate matter 2.5 (PM2.5; HR: 1.16 [95% CI: 1.09-1.24] per 10 µg/m³ increase), higher nitrogen dioxide (NO2; HR: 1.05 [95% CI: 1.02-1.07] per 10 ppb increase), road traffic noise (RR: 1.03 [95% CI: 1.02-1.05] per 10dB increase), and high neighbourhood-level deprivation (RR: 1.24 [95% CI: 1.17-1.31] vs. low) were each associated with increased risk of incident CVD development.</p><p><strong>Conclusion: </strong>Our findings indicate a modest yet significant increase in CVD risk associated with elevated levels of air pollution, road noise and neighbourhood deprivation, emphasising these exposures as consequential targets for policy intervention.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulative Blood Pressure Exposure and Global and Regional Cardiac Structure and Function: The MESA Study.","authors":"Soroush Masrouri, Peyman Tabnak, Parag Chevli, Saeid Mirzai, Leandro Slipczuk, Sujethra Vasu, Joao A C Lima, Michael D Shapiro","doi":"10.1093/eurjpc/zwaf163","DOIUrl":"https://doi.org/10.1093/eurjpc/zwaf163","url":null,"abstract":"<p><strong>Aims: </strong>This study examined the associations between decade-long cumulative blood pressure (BP) exposure and global/regional myocardial structure and function independent of current BP levels.</p><p><strong>Methods: </strong>We analyzed 3,015 adults (aged 69.0±9.2 years) from the Multi-Ethnic Study of Atherosclerosis (MESA) who underwent cardiac magnetic resonance (CMR) imaging at year 10 (exam 5, 2010-2012). Measures included left ventricular (LV) parameters, global/regional myocardial function via tagged CMR, interstitial myocardial fibrosis (IMF) via T1-mapping measures (native T1 and extracellular volume fraction [ECV]), and myocardial scar via late gadolinium enhancement (LGE). We used cumulative exposure of BP through baseline and up to exam 5 (millimeters of mercury × year) to represent long-term exposure to BP levels. Linear regression, logistic regression, and generalized additive models were used to quantify the association of cumulative BP parameters with measures of cardiac structure and function.</p><p><strong>Results: </strong>Higher cumulative systolic BP (SBP), independent of current SBP, correlated with increased LV mass index (1.93 g/m² per SD), worse global/regional circumferential strain (0.24% to 0.38% lower absolute values per SD), and greater myocardial scar risk (OR: 1.36, 95% CI: 1.02-1.82 per SD). Cumulative diastolic BP (DBP) was associated with circumferential strain, showing nearly J-shaped relationships after adjusting for current DBP (all P < 0.05). In non-hypertensive individuals with BP consistently below the hypertension threshold, cumulative SBP remained significantly associated with LV mass index and strain but not myocardial scar (OR: 1.53, 95% CI: 0.82-2.87, P=0.19).</p><p><strong>Conclusion: </strong>Higher cumulative BP was associated with worse global and regional cardiac structure/function and myocardial scar, independent of a single BP at the time of imaging, and was still observed to some extent in non-hypertensive individuals who consistently maintained blood pressure levels below the hypertension threshold.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}