{"title":"红细胞奇链脂肪酸与心脏代谢疾病的风险：一项前瞻性研究和最新荟萃分析","authors":"Liang Sun, Xinming Xu, Huaidong Du, Ling Lu, Fumiaki Imamura, Qishan Yang, Yiping Chen, Yan Chen, Pei Pei, Huiyong Yin, Ling Yang, Geng Zong, Canqing Yu, Qianqian Chu, Jun Lv, Puchen Zhou, Dianjianyi Sun, Junshi Chen, Xiang Gao, Liming Li, Zhengming Chen, Xu Lin","doi":"10.1093/eurjpc/zwaf601","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>To determine dietary sources of odd-chain fatty acids (OCFAs) in Asians and their associations with cardiometabolic diseases (CMDs) and to compare these associations with other populations.</p><p><strong>Methods: </strong>Erythrocyte fatty acids were profiled in 8,185 subjects (38% men, mean age 58.1 years) participating in the 2nd resurvey of the China Kadoorie Biobank (CKB) in 2013-14 using gas chromatography. Correlations of pentadecanoic (15:0) and heptadecanoic (17:0) acids with dietary factors, assessed via food frequency questionnaires, were examined by Spearman correlations. During about 5-year follow-up, 950 incident CMD were recorded, including 387 ischemic heart disease (IHD), 127 diabetes, and 459 stroke. Cox regression yielded adjusted hazard ratios (HRs) for CMDs associated with levels of 15:0. These results were further meta-analyzed with 33 additional prospective studies, involving 112,193 participants.</p><p><strong>Results: </strong>OCFAs were significantly correlated with intakes of dairy products, wheat and coarse grains, and fish/seafood in the CKB. Both 15:0 and 17:0 were inversely associated with incident IHD, with adjusted HRs of 0.72 (95% CI 0.59-0.89) and 0.69 (0.56-0.86) for top vs. bottom tertile, respectively. Levels of 17:0 were also inversely associated with incident diabetes (0.41 [0.27-0.62]) and total CMDs (0.85 [0.74-0.97]). In the updated meta-analysis, both 15:0 and 17:0 levels showed inverse associations with diabetes, with pooled relative risks of 0.74 (0.68-0.80) and 0.65 (0.61-0.71) per 10th-90th percentile range, respectively. 17:0 was also inversely associated with incident IHD (0.87 [0.77-0.97]).</p><p><strong>Conclusions: </strong>Our findings supported favorable associations between OCFAs and CMDs among populations with varied dietary sources and intake levels, which merits future intervention studies.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":7.5000,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Erythrocyte odd-chain fatty acids and the risk of cardiometabolic diseases: a prospective study and updated meta-analysis.\",\"authors\":\"Liang Sun, Xinming Xu, Huaidong Du, Ling Lu, Fumiaki Imamura, Qishan Yang, Yiping Chen, Yan Chen, Pei Pei, Huiyong Yin, Ling Yang, Geng Zong, Canqing Yu, Qianqian Chu, Jun Lv, Puchen Zhou, Dianjianyi Sun, Junshi Chen, Xiang Gao, Liming Li, Zhengming Chen, Xu Lin\",\"doi\":\"10.1093/eurjpc/zwaf601\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>To determine dietary sources of odd-chain fatty acids (OCFAs) in Asians and their associations with cardiometabolic diseases (CMDs) and to compare these associations with other populations.</p><p><strong>Methods: </strong>Erythrocyte fatty acids were profiled in 8,185 subjects (38% men, mean age 58.1 years) participating in the 2nd resurvey of the China Kadoorie Biobank (CKB) in 2013-14 using gas chromatography. Correlations of pentadecanoic (15:0) and heptadecanoic (17:0) acids with dietary factors, assessed via food frequency questionnaires, were examined by Spearman correlations. During about 5-year follow-up, 950 incident CMD were recorded, including 387 ischemic heart disease (IHD), 127 diabetes, and 459 stroke. Cox regression yielded adjusted hazard ratios (HRs) for CMDs associated with levels of 15:0. These results were further meta-analyzed with 33 additional prospective studies, involving 112,193 participants.</p><p><strong>Results: </strong>OCFAs were significantly correlated with intakes of dairy products, wheat and coarse grains, and fish/seafood in the CKB. Both 15:0 and 17:0 were inversely associated with incident IHD, with adjusted HRs of 0.72 (95% CI 0.59-0.89) and 0.69 (0.56-0.86) for top vs. bottom tertile, respectively. Levels of 17:0 were also inversely associated with incident diabetes (0.41 [0.27-0.62]) and total CMDs (0.85 [0.74-0.97]). In the updated meta-analysis, both 15:0 and 17:0 levels showed inverse associations with diabetes, with pooled relative risks of 0.74 (0.68-0.80) and 0.65 (0.61-0.71) per 10th-90th percentile range, respectively. 17:0 was also inversely associated with incident IHD (0.87 [0.77-0.97]).</p><p><strong>Conclusions: </strong>Our findings supported favorable associations between OCFAs and CMDs among populations with varied dietary sources and intake levels, which merits future intervention studies.</p>\",\"PeriodicalId\":12051,\"journal\":{\"name\":\"European journal of preventive cardiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":7.5000,\"publicationDate\":\"2025-09-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European journal of preventive cardiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/eurjpc/zwaf601\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European journal of preventive cardiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/eurjpc/zwaf601","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0
摘要
目的：确定亚洲人饮食中奇链脂肪酸（OCFAs）的来源及其与心脏代谢疾病（cmd）的关系，并将这些关系与其他人群进行比较。方法：采用气相色谱法对2013- 2014年中国嘉里生物库（CKB）第二次调查的8185名受试者（男性38%，平均年龄58.1岁）的红细胞脂肪酸进行分析。通过食物频率问卷评估五烷酸（15:0）和十七烷酸（17:0）与饮食因素的相关性，并采用Spearman相关性进行检验。在大约5年的随访中，记录了950例CMD事件，其中包括387例缺血性心脏病（IHD）， 127例糖尿病和459例中风。Cox回归得到了与15:0水平相关的CMDs的校正风险比（hr）。这些结果与33项额外的前瞻性研究进行了进一步的荟萃分析，涉及112,193名参与者。结果：OCFAs与CKB中乳制品、小麦和粗粮以及鱼类/海鲜的摄入量显著相关。15:0和17:0与IHD事件呈负相关，顶/底四分位数调整后的hr分别为0.72 （95% CI 0.59-0.89）和0.69（0.56-0.86）。17:0水平也与糖尿病的发生（0.41[0.27-0.62]）和总心血管疾病（0.85[0.74-0.97]）呈负相关。在最新的荟萃分析中，15:0和17:0水平与糖尿病呈负相关，每10 -90百分位范围内的综合相对风险分别为0.74（0.68-0.80）和0.65（0.61-0.71）。17:0与IHD的发生也呈负相关（0.87[0.77-0.97]）。结论：我们的研究结果支持在不同饮食来源和摄入水平的人群中，OCFAs和cmd之间存在良好的关联，值得未来的干预研究。
Erythrocyte odd-chain fatty acids and the risk of cardiometabolic diseases: a prospective study and updated meta-analysis.
Aim: To determine dietary sources of odd-chain fatty acids (OCFAs) in Asians and their associations with cardiometabolic diseases (CMDs) and to compare these associations with other populations.
Methods: Erythrocyte fatty acids were profiled in 8,185 subjects (38% men, mean age 58.1 years) participating in the 2nd resurvey of the China Kadoorie Biobank (CKB) in 2013-14 using gas chromatography. Correlations of pentadecanoic (15:0) and heptadecanoic (17:0) acids with dietary factors, assessed via food frequency questionnaires, were examined by Spearman correlations. During about 5-year follow-up, 950 incident CMD were recorded, including 387 ischemic heart disease (IHD), 127 diabetes, and 459 stroke. Cox regression yielded adjusted hazard ratios (HRs) for CMDs associated with levels of 15:0. These results were further meta-analyzed with 33 additional prospective studies, involving 112,193 participants.
Results: OCFAs were significantly correlated with intakes of dairy products, wheat and coarse grains, and fish/seafood in the CKB. Both 15:0 and 17:0 were inversely associated with incident IHD, with adjusted HRs of 0.72 (95% CI 0.59-0.89) and 0.69 (0.56-0.86) for top vs. bottom tertile, respectively. Levels of 17:0 were also inversely associated with incident diabetes (0.41 [0.27-0.62]) and total CMDs (0.85 [0.74-0.97]). In the updated meta-analysis, both 15:0 and 17:0 levels showed inverse associations with diabetes, with pooled relative risks of 0.74 (0.68-0.80) and 0.65 (0.61-0.71) per 10th-90th percentile range, respectively. 17:0 was also inversely associated with incident IHD (0.87 [0.77-0.97]).
Conclusions: Our findings supported favorable associations between OCFAs and CMDs among populations with varied dietary sources and intake levels, which merits future intervention studies.
期刊介绍：
European Journal of Preventive Cardiology (EJPC) is an official journal of the European Society of Cardiology (ESC) and the European Association of Preventive Cardiology (EAPC). The journal covers a wide range of scientific, clinical, and public health disciplines related to cardiovascular disease prevention, risk factor management, cardiovascular rehabilitation, population science and public health, and exercise physiology. The categories covered by the journal include classical risk factors and treatment, lifestyle risk factors, non-modifiable cardiovascular risk factors, cardiovascular conditions, concomitant pathological conditions, sport cardiology, diagnostic tests, care settings, epidemiology, pharmacology and pharmacotherapy, machine learning, and artificial intelligence.
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