European Journal of Clinical Investigation最新文献

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":"56 5","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148088493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":"56 4","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148082404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":"56 4","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148082403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":"56 4","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148081477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic Added Value of GFAP in Patients With Minor Ischemic Stroke","authors":"Andrea Morotti, Mathias Sauer, Francesco Berinato, Marcello Catania, Andrea L. Benedet, Chiara Tolassi, Guglielmo Di Molfetta, Ilaria Pola, Henrik Zetterberg, Nicholas J. Ashton, Andrea Pilotto, Alessandro Padovani","doi":"10.1111/eci.70203","DOIUrl":"10.1111/eci.70203","url":null,"abstract":"","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":"56 4","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147662571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The emerging problem of digital and self misuse of obesity management medications: Protecting their clinical value","authors":"Leonilde Bonfrate, Alfredo Caturano, Caterina Conte","doi":"10.1111/eci.70201","DOIUrl":"10.1111/eci.70201","url":null,"abstract":"","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":"56 4","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From biology to imaging: Rethinking vulnerable plaques in coronary artery disease","authors":"Edoardo Elia,&nbsp;Federico Carbone,&nbsp;Marco Lombardi,&nbsp;Andrea Demarchi,&nbsp;Giovanni La Malfa,&nbsp;Vincenzo Fiorentini,&nbsp;Andrea Audo,&nbsp;Giulia Maj,&nbsp;Fabrizio Montecucco,&nbsp;Giuseppe Patti,&nbsp;Gioel Gabrio Secco","doi":"10.1111/eci.70202","DOIUrl":"10.1111/eci.70202","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Coronary artery disease continues to be a leading cause of morbidity and mortality worldwide with atherosclerosis as its underlying cause. Initial pathological studies emphasized plaque rupture as the main trigger of acute coronary syndromes (ACS). Subsequent observations identified alternative substrates, such as plaque erosion and calcific nodules, while research has increasingly recognized atherosclerosis as a chronic, inflammatory and panvascular disorder.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Results</h3>\u0000 \u0000 <p>This review critically examines current evidence on plaque vulnerability and destabilization, with a focus on intravascular imaging (IVI) findings. Optical coherence tomography, intravascular ultrasound and near-infrared spectroscopy have enabled detailed in vivo characterization of high-risk phenotypes, including thin-cap fibroatheromas, lipid-rich cores, macrophage infiltration, microcalcifications and intraplaque haemorrhage. These advances have improved pathophysiological understanding. However, the translation of imaging surrogates into prognostic tools remains uncertain. Although multiple studies have shown associations between imaging-derived vulnerability features and major cardiovascular events, lesion-specific prediction is inconsistent and preventive percutaneous treatment has not demonstrated clear benefit in terms of survival or myocardial infarction reduction. By contrast, intensive lipid-lowering and anti-inflammatory strategies have consistently promoted plaque stabilization and regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Despite the insights offered by high-resolution IVI, vulnerable plaques should be considered as markers of global patient risk rather than reliable predictors of culprit lesions. Current evidence does not support routine pre-emptive intervention on non-culprit vulnerable plaques. Instead, optimized medical therapy remains the cornerstone of management. Future progress will depend on longitudinal studies integrating imaging, biology and clinical outcomes to bridge the gap between mechanistic understanding and therapeutic application.</p>\u0000 </section>\u0000 </div>","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":"56 4","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147627328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Anaemia on Management and Outcomes in Patients With Atrial Fibrillation: Insights From European and Asian Cohorts.","authors":"Andrea Galeazzo Rigutini, Tommaso Bucci, Amir Askarinejad, Enrico Tartaglia, Michele Rossi, Cecilia Becattini, Giuseppe Boriani, Hung-Fat Tse, Tze-Fan Chao, Gregory Y H Lip","doi":"10.1111/eci.70205","DOIUrl":"10.1111/eci.70205","url":null,"abstract":"<p><strong>Background: </strong>Anaemia is a common comorbidity in patients with atrial fibrillation (AF) receiving oral anticoagulants (OACs). While its relationship with bleeding is well established, the prothrombotic role and ethnic variations remain unclear.</p><p><strong>Methods: </strong>We analysed two large prospective AF registries from Europe (EORP-AF) and East Asia (APHRS-AF). Patients were classified by anaemia status at enrolment. Logistic regression assessed clinical correlates and treatment patterns, while multivariable Cox models and propensity score matching (PSM) evaluated outcomes. Restricted cubic spline analyses explored the haemoglobin-risk relationship across ethnic groups. The primary outcome was a composite of all-cause death and major adverse cardiovascular events (MACE); secondary outcomes included individual components and major bleeding (MB).</p><p><strong>Results: </strong>Among 10,857 patients with AF (mean age 69 ± 11 years, 40.0% women), 3372 (31.0%) had anaemia, which clustered with multimorbidity and frailty. Anaemic patients were less likely to receive OACs (OR 0.67, 95% CI 0.58-0.78) and rhythm-control (OR 0.91, 95% CI 0.81-1.02). Anaemia was independently associated with higher risk of the composite outcome (HR 1.54, 95% CI 1.34-1.78), all-cause death (HR 1.81, 95% CI 1.51-2.15), MACE (HR 1.39, 95% CI 1.16-1.66), CV death (HR 1.90, 95% CI 1.43-2.54) and MB (HR 1.79, 95% CI 1.31-2.46) consistent also after PSM. Risk increased progressively with anaemia severity, particularly below 10 g/dL. Associations were consistent across Asian and European cohorts.</p><p><strong>Conclusion: </strong>Anaemia identifies a vulnerable AF phenotype associated with excess mortality, adverse cardiovascular outcomes and increased bleeding risk, which remains frequently undertreated. Risk rises with anaemia severity, and although biological effects appear consistent across ethnicities, treatment disparities persist. Anaemia should refine, not restrict, therapy within integrated AF care.</p>","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":"56 4","pages":"e70205"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13091571/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The high-density lipoprotein lipidome in metabolic syndrome: A systematic review.","authors":"Elena Grao-Cruces, Gabriel García-Jiménez, Maria E Martin, Gabriele Mocciaro, Elena Osto, Sergio Montserrat-de la Paz, Lourdes M Varela","doi":"10.1111/eci.70195","DOIUrl":"10.1111/eci.70195","url":null,"abstract":"<p><strong>Background: </strong>Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors, including low high-density lipoprotein cholesterol (HDL-C) levels. Although HDL-C is an established cardiovascular biomarker, in MetS this marker captures only a fraction of the profound alterations occurring within HDL particles. The cardiometabolic role of HDLs in MetS remains insufficiently understood because the functional properties and molecular components of HDLs, rather than HDL-C alone, are likely key determinants of cardiovascular risk. Since the early 2000s, research has revealed that HDL particles comprise over 280 proteins and more than 300 lipid species, underscoring their biological complexity. Moreover, HDL composition and function are extensively remodelled in MetS, highlighting the importance of characterising the differences in HDL composition between health and disease. In this systematic review, we aimed to examine differences in the HDL lipidome between MetS patients and healthy controls.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in MEDLINE, Cochrane Library, and Web of Science. The PRISMA guidelines for systematic reviews were followed, and four records met the eligibility criteria.</p><p><strong>Results: </strong>Overall, the HDL lipidome was markedly different in MetS compared with healthy individuals. MetS was consistently associated with higher levels of triacylglycerides (TAGs) and phosphatidylinositol, alongside lower levels of several key lipid families, indicating a broad remodelling of HDL composition.</p><p><strong>Conclusions: </strong>These findings indicate that the HDL lipidome is substantially altered in MetS, with potential consequences for HDL functionality. Although the mechanistic implications remain to be fully elucidated, TAG enrichment may contribute to lower HDL levels and changes in HDL surface lipids may impair essential functions such as cholesterol efflux. Further studies are needed to validate these patterns and determine their impact on HDL function and cardiometabolic risk.</p>","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":"56 4","pages":"e70195"},"PeriodicalIF":4.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13091569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147716423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging in Focus: A Comprehensive View for Enhancing Healthspan.","authors":"Federico Carbone, Luca Liberale","doi":"10.1111/eci.70207","DOIUrl":"https://doi.org/10.1111/eci.70207","url":null,"abstract":"","PeriodicalId":12013,"journal":{"name":"European Journal of Clinical Investigation","volume":"56 4","pages":"e70207"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147697803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}