Changes in ghrelin isoforms after sleeve gastrectomy or gastric plication and their association with adiposity and metabolic profile.

IF 4.4 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

European Journal of Clinical Investigation Pub Date : 2025-03-20 DOI:10.1111/eci.70031

Carlota Tuero, Sara Becerril, Beatriz Ramirez, Victoria Catalán, Javier A Cienfuegos, María A Burrell, Victor Valenti, Rafael Moncada, Javier Gomez-Ambrosi, Amaia Rodriguez, Gema Frühbeck

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引用次数: 0

Abstract

Background & aims: Sleeve gastrectomy (SG) and gastric plication (GP) are two widely performed bariatric techniques reducing the size of the stomach. The improvements observed following these procedures are not fully explained only by caloric restriction. Thus, we aimed at the analysis of adiposity and metabolism modifications in diet-induced obesity (DIO) rats submitted to SG or GP and correlate the changes with total ghrelin concentrations and its two different ghrelin isoforms.

Materials and methods: Adiposity, lipolysis and circulating ghrelin isoforms were determined in 191 male Wistar rats submitted to surgery: sham (SO), SG, or GP. Results were compared with pair-fed (PF) controls fed either a normal diet (ND) or a high-fat diet (HFD).

Results: DIO rats submitted to SG had significantly lower (p < .05) levels of desacyl ghrelin (DAG) and total ghrelin compared with SO and PF ones. Furthermore, they achieved a greater weight loss, adiposity and improvement in glucose and lipid metabolism, as well as brown adipose tissue mitochondrial morphology. No decrease in ghrelin concentrations was observed in GP.

Conclusions: The differential effect on circulating ghrelin concentrations of SG and GP, despite both procedures reducing actual stomach size, probably underlies the better outcomes on weight control and lipolysis of the SG due to the fundus removal, the main site of ghrelin-producing cells.

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袖式胃切除术或胃应用后胃促生长素亚型的变化及其与肥胖和代谢谱的关系。

背景与目的：袖胃切除术（SG）和胃应用（GP）是两种广泛应用的减肥技术，可以减少胃的大小。在这些步骤之后观察到的改善并不能完全用热量限制来解释。因此，我们旨在分析饮食性肥胖（DIO）大鼠在SG或GP治疗下的肥胖和代谢变化，并将其与总胃饥饿素浓度及其两种不同的胃饥饿素亚型相关联。材料和方法：191只雄性Wistar大鼠接受手术，分别为假手术（SO）、SG和GP，测定其肥胖、脂肪分解和循环胃饥饿素亚型。结果与饲喂正常饲粮（ND）或高脂饲粮（HFD）的配对饲喂（PF）对照组进行了比较。结论：SG和GP对胃饥饿素循环浓度的不同影响，尽管两种方法都减少了实际胃大小，但可能是由于去除了胃饥饿素产生细胞的主要部位——眼底，SG在体重控制和脂肪分解方面效果更好。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Clinical Investigation 医学-医学：内科

CiteScore

9.50

自引率

3.60%

发文量

192

审稿时长

1 months

期刊介绍： EJCI considers any original contribution from the most sophisticated basic molecular sciences to applied clinical and translational research and evidence-based medicine across a broad range of subspecialties. The EJCI publishes reports of high-quality research that pertain to the genetic, molecular, cellular, or physiological basis of human biology and disease, as well as research that addresses prevalence, diagnosis, course, treatment, and prevention of disease. We are primarily interested in studies directly pertinent to humans, but submission of robust in vitro and animal work is also encouraged. Interdisciplinary work and research using innovative methods and combinations of laboratory, clinical, and epidemiological methodologies and techniques is of great interest to the journal. Several categories of manuscripts (for detailed description see below) are considered: editorials, original articles (also including randomized clinical trials, systematic reviews and meta-analyses), reviews (narrative reviews), opinion articles (including debates, perspectives and commentaries); and letters to the Editor.