European Journal of Applied Physiology最新文献_第3页

The effects of chronic beetroot juice supplementation with resistance training on skeletal muscle mitochondrial and redox markers in middle-aged and older adults. 慢性甜菜根汁补充抗阻训练对中老年人骨骼肌线粒体和氧化还原标志物的影响。

IF 2.9 3区医学

European Journal of Applied Physiology Pub Date : 2026-10-03 DOI: 10.1007/s00421-026-06460-x

Breanna J Mueller, Mason C McIntosh, Dakota R Tiede, Derick A Anglin, George J Kontos, Dustyn T Lewis, Michael D Goodlett, Andrew D Frugé, Christopher B Mobley, Robert L Judd, Darren T Beck, Michael D Roberts, Andreas N Kavazis

{"title":"The effects of chronic beetroot juice supplementation with resistance training on skeletal muscle mitochondrial and redox markers in middle-aged and older adults.","authors":"Breanna J Mueller, Mason C McIntosh, Dakota R Tiede, Derick A Anglin, George J Kontos, Dustyn T Lewis, Michael D Goodlett, Andrew D Frugé, Christopher B Mobley, Robert L Judd, Darren T Beck, Michael D Roberts, Andreas N Kavazis","doi":"10.1007/s00421-026-06460-x","DOIUrl":"https://doi.org/10.1007/s00421-026-06460-x","url":null,"abstract":"Purpose: Acute nitrate-rich beetroot juice (BRJ) supplementation has been shown to improve aspects of endurance exercise performance. These effects may, in part, be due to nitric oxide-mediated effects on skeletal muscle contractility and mitochondrial function. However, no studies have investigated the effects of chronic BRJ supplementation with resistance training (RT) on molecular markers of mitochondrial adaptation and redox state within the skeletal muscle of older adults. Likewise, whether supplementation affects functional outcomes in this population is unresolved.Methods: In the current study, 27 older adults (56 ± 7 years old, 85.9 ± 20.6 kg, 36.1 ± 8.3% body fat) were block-randomized to consume either a nitrate-depleted (Placebo) or nitrate-rich (~ 13 mmol) BRJ daily and complete 12 weeks of supervised total body RT (2 days per week). Vastus lateralis (VL) biopsies and measurements of leg extensor peak force, strength-endurance, and fatigue were obtained prior to training and ~72 h following the last training bout.Results: In all participants, RT increased VL citrate synthase activity (i.e., mitochondrial content), certain proteins indicative of mitochondrial biogenesis and dynamics, and most leg extensor performance variables. However, BRJ supplementation did not confer additional benefits with any of the outcomes.Conclusions: RT in middle-aged and older adults dynamically alters muscle mitochondrial markers and knee extensor performance variables, albeit increased dietary BRJ consumption does not confer additional benefits.","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in cardiometabolic and perceptual responses to high-intensity functional training and kettlebell complexes. 对高强度功能训练和壶铃复合体的心脏代谢和知觉反应的性别差异。

IF 2.9 3区医学

European Journal of Applied Physiology Pub Date : 2026-10-03 DOI: 10.1007/s00421-026-06455-8

Brandon J Bullert, Osmar Pinto Neto, Devin L Jindrich, Robert Sturdy, Todd A Astorino

{"title":"Sex differences in cardiometabolic and perceptual responses to high-intensity functional training and kettlebell complexes.","authors":"Brandon J Bullert, Osmar Pinto Neto, Devin L Jindrich, Robert Sturdy, Todd A Astorino","doi":"10.1007/s00421-026-06455-8","DOIUrl":"https://doi.org/10.1007/s00421-026-06455-8","url":null,"abstract":"Purpose: This study examined sex differences in cardiometabolic and perceptual responses to high-intensity functional training (HIFT) and kettlebell complexes (KC).Methods: Seventeen men (age = 26.9 ± 9.5 year) and 18 women (age = 22.2 ± 2.8 year) completed HIFT and KC protocols. Oxygen consumption (VO2), heart rate (HR), ventilation (VE), respiratory exchange ratio (RER), blood lactate concentration (BLa), rating of perceived exertion (RPE), and the Feeling Scale (FS) were measured during exercise.Results: Women demonstrated significantly higher (p ≤ 0.001) mean HR (156 ± 14 vs. 134 ± 17 b·min⁻¹), %HRmax (84 ± 8 vs. 76 ± 8), %VEmax (62 ± 16 vs. 52 ± 12), peak HR (183 ± 8 vs. 167 ± 15 b·min⁻¹), and higher RER (1.11 ± 0.08 vs. 1.05 ± 0.10) versus men. Relative VO2 (%VO2max: 62 ± 8 vs. 59 ± 10) did not differ between sexes (p = 0.285), despite men exhibiting higher absolute VO2 (1.87 ± 0.40 vs. 1.37 ± 0.26 L·min⁻¹; p < 0.001). No sex differences were revealed in BLa (p = 0.78), RPE (p = 0.78), or FS (p = 0.76). HIFT elicited significantly higher (p < 0.001) mean VO2 (%VO2max: 63 ± 8 vs. 58 ± 10), peak VO2 (%VO2peak: 81 ± 12 vs. 73 ± 11), VE (%VEmax: 61 ± 15 vs. 54 ± 14), and RER (1.11 ± 0.10 vs. 1.05 ± 0.09) versus KC.Conclusion: Women exhibited greater relative internal load during exercise despite similar relative VO2, suggesting a greater cardiovascular stimulus during whole-body interval training.","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":""},"PeriodicalIF":2.9,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skeletal muscle histological remodeling precedes functional impairment in a muscle-specific manner following monocrotaline-induced heart failure in rats. 骨骼肌组织重塑先于肌肉特异性方式的功能损害后，在大鼠单艾罗塔碱诱导的心力衰竭。

IF 2.9 3区医学

European Journal of Applied Physiology Pub Date : 2026-10-01 Epub Date: 2026-06-18 DOI: 10.1007/s00421-026-06308-4

Akinori Kaneguchi, Mahiro Fukunaga, Mikito Nishimura, Reo Takagi, Shota Yamamoto, Akira Yukitomo, Haru Honma, Takuya Umehara, Kaoru Yamaoka, Junya Ozawa

{"title":"Skeletal muscle histological remodeling precedes functional impairment in a muscle-specific manner following monocrotaline-induced heart failure in rats.","authors":"Akinori Kaneguchi, Mahiro Fukunaga, Mikito Nishimura, Reo Takagi, Shota Yamamoto, Akira Yukitomo, Haru Honma, Takuya Umehara, Kaoru Yamaoka, Junya Ozawa","doi":"10.1007/s00421-026-06308-4","DOIUrl":"10.1007/s00421-026-06308-4","url":null,"abstract":"Purpose: Skeletal muscle remodeling in heart failure contributes to exercise intolerance and muscle weakness, but the temporal relationship between histological alterations and functional impairment remains poorly understood. We aimed to clarify whether histological changes in skeletal muscle precede the onset of functional impairment.Methods: Rats were allocated into either a normal control group (n = 21) or a monocrotaline-induced heart failure group (n = 42) and evaluated at 1, 2, or 4 weeks after injection. We assessed motor function (grip strength and exhaustive running), organ weights, and histological changes in three hindlimb muscles: the soleus (predominantly slow-twitch), the medial head of the gastrocnemius (superficial fast-twitch and deep mixed-fiber regions), and the plantaris (predominantly fast-twitch).Results: Heart failure rats exhibited pulmonary congestion at 1 week, followed by progressive right ventricular hypertrophy from 2 to 4 weeks. Overt declines in exercise tolerance and a downward trend in grip strength became apparent at 4 weeks. Notably, reductions in the capillary-to-fiber ratio were detected in the deep gastrocnemius and plantaris as early as 1 week, and in the superficial gastrocnemius at 2 weeks. In contrast, muscle fiber atrophy in these muscles generally manifested later (at 2 or 4 weeks). In the soleus, both capillary loss and fiber atrophy were delayed until 4 weeks.Conclusion: Microcirculatory disturbances and subsequent fiber atrophy, particularly in fast-twitch-dominant muscles, precede functional impairments, such as reduced grip strength and exercise intolerance. Early comprehensive management before functional deficits become apparent may be necessary to mitigate heart failure-associated skeletal muscle impairment.","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":"5115-5127"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148271092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic effects of different exercise modalities on autonomic recovery: a longitudinal study based on heart rate variability. 不同运动方式对自主神经恢复的动态影响：一项基于心率变异的纵向研究。

IF 2.9 3区医学

European Journal of Applied Physiology Pub Date : 2026-10-01 Epub Date: 2026-06-29 DOI: 10.1007/s00421-026-06329-z

Wenxing Wang, Xiong Qin, Jiaqi Xu, Yuanhui Zhao, Hong Ren

{"title":"Dynamic effects of different exercise modalities on autonomic recovery: a longitudinal study based on heart rate variability.","authors":"Wenxing Wang, Xiong Qin, Jiaqi Xu, Yuanhui Zhao, Hong Ren","doi":"10.1007/s00421-026-06329-z","DOIUrl":"10.1007/s00421-026-06329-z","url":null,"abstract":"Purpose Post-exercise recovery is a critical window for physiological adaptation, with the autonomic nervous system (ANS) playing a key regulatory role. However, whether long-term training with different modalities systematically influences post-exercise ANS recovery remains unclear. This study investigated the long-term effects of moderate-intensity continuous training (MICT), high-intensity interval training (HIIT), and resistance training (RT) on post-exercise ANS recovery assessed by heart rate variability (HRV) in healthy adults. Methods Three independent cohorts completed 12 weeks of MICT, HIIT, or RT (3 sessions per week). 5-minute continuous HRV data were collected immediately after each session. Recovery slopes of the root mean square of successive differences (RMSSD) and low-frequency/high-frequency power (LF/HF) ratio were calculated. Linear mixed-effects models analyzed trends in recovery slopes across training weeks, with pre-exercise resting HRV and prior-night insomnia score as covariates. Results A total of 43 participants (MICT: n = 13; HIIT: n = 16; RT: n = 14) completed the intervention, yielding 1393 training observations. RMSSD recovery slope decreased significantly in MICT (b=-0.165, P = 0.003), but not in HIIT (b = 0.019, P = 0.680) or RT (b=-0.037, P = 0.452). Between-group comparisons showed a significant difference between HIIT and MICT (Δb = 0.184, P = 0.030). Pre-exercise resting RMSSD (β = 0.022, P < 0.001) and prior-night insomnia score (β = 0.052, P = 0.021) significantly influenced RMSSD recovery slope. No observable trend was detected in LF/HF ratio recovery slopes. Conclusion Long-term training with different exercise modalities differentially affects post-exercise ANS recovery. MICT potentially promotes economical autonomic adaptation; HIIT maintains rapid recovery capacity; RT exerts weaker effects. Pre-exercise resting RMSSD and sleep quality may serve as practical markers for daily training monitoring.","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":"5197-5210"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148344389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of rifle carriage on performance, physiological responses, power output and external work in a simulated biathlon competition. 在模拟冬季两项比赛中，步枪架对成绩、生理反应、功率输出和外部工作的影响。

IF 2.9 3区医学

European Journal of Applied Physiology Pub Date : 2026-10-01 Epub Date: 2026-06-29 DOI: 10.1007/s00421-026-06301-x

M Jonsson Kårström, M Horvath, E P Andersson, M S Laaksonen

{"title":"Effects of rifle carriage on performance, physiological responses, power output and external work in a simulated biathlon competition.","authors":"M Jonsson Kårström, M Horvath, E P Andersson, M S Laaksonen","doi":"10.1007/s00421-026-06301-x","DOIUrl":"10.1007/s00421-026-06301-x","url":null,"abstract":"Purpose: To investigate the effect of rifle carriage on performance, physiological responses, power output and external work during a simulated biathlon competition in the field.Methods: Twenty well-trained biathletes (10 women) completed a simulated biathlon competition (women 3 × 1.9 km, men 3 × 2.4 km) twice, one trial while carrying the rifle (WR) and the other without rifle (NR) in a randomized counter-balanced order. Laps were separated by two simulated shootings, lasting 38.9 ± 8.2 s. Trials were separated by 30-min of active recovery. Heart rate and respiratory variables were measured throughout each trial. Furthermore, blood lactate concentration and ratings of perceived exertion were assessed after each lap. Power output and external work were estimated for both trials based on positional data.Results: Overall roller-skiing speed was lower WR than NR (5.49 ± 0.47 vs. 5.69 ± 0.49 m∙s-1, p < 0.001), with largest differences during the uphill sections. No differences in physiological responses were found between WR and NR during laps or course sections (p > 0.05), but oxygen uptake and breathing frequency were higher WR than NR during the second simulated shooting (p < 0.05). Mean power output was slightly lower WR than NR; however, the participants performed more external work WR compared to NR due to the longer duration of the WR trial (both p < 0.05).Conclusion: Since elevated physiological markers may negatively impact standing shooting performance, biathletes should optimize their pacing strategies to maximize overall performance. In addition, rifle carriage increases external work through a lengthened skiing duration, which should be considered when planning and performing biathlon training.","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":"5319-5333"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13633986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148344386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kinetics of submaximal DFA α1 prior and post maximal efforts in trained and highly trained male and female cyclists. 训练有素和高度训练的男女自行车运动员的亚极限DFA α1在最大努力前后的动力学。

IF 2.9 3区医学

European Journal of Applied Physiology Pub Date : 2026-10-01 Epub Date: 2026-07-02 DOI: 10.1007/s00421-026-06267-w

Felipe Rayo Martín, Thomas Gronwald, Peter Düking

{"title":"Kinetics of submaximal DFA α1 prior and post maximal efforts in trained and highly trained male and female cyclists.","authors":"Felipe Rayo Martín, Thomas Gronwald, Peter Düking","doi":"10.1007/s00421-026-06267-w","DOIUrl":"10.1007/s00421-026-06267-w","url":null,"abstract":"Purpose: To investigate the kinetics of a non-linear heart rate (HR) variability parameter (DFA α1) during submaximal cycling in male and female trained and highly trained cyclists in a non-fatigued state and after repeated maximal cycling bouts.Methods: N = 47 participants (17 female) completed a cycling protocol consisting of two blocks (Block1, Block2), each including two standardised submaximal cycling bouts performed prior (PRE) and post a maximal incremental test (POST), having four time points (Block1: PRE1-POST1; Block2: PRE2-POST2). DFA α1, oxygen consumption ([Formula: see text]), HR, respiratory frequency (RF) and rating of perceived exertion (RPE) were assessed during the submaximal bouts, and [Formula: see text] peak and maximal power output (Wmax) during the maximal tests. A linear mixed effects model was used to analyse data.Results: Block2 showed significantly lower [Formula: see text] peak (β = - 2.51 mL·kg⁻¹·min⁻¹) and Wmax (β = - 24.3 W) values. DFA α1 decreased significantly from PRE1 (1.32 ± 0.19) to POST1 (1.12 ± 0.34) and remained suppressed at Block2 (1.14 ± 0.31, 1.09 ± 0.35). [Formula: see text] (+ 2.37 mL·kg⁻1·min⁻1), HR (+ 15 bpm), RF (+ 8 breaths/min) and RPE (+ 2) increased significantly in Block1 and stayed elevated in Block2. Following POST2, HR decreased (-4 bpm) and RF increased (+ 1 breaths/min) significantly. Training status significantly influenced absolute levels of DFA α1, HR, and [Formula: see text], but did not influence RPE or RF. Sex did not significantly alter kinetics of DFA α1, HR, V̇O₂, RPE and RF.Conclusion: DFA α1 during submaximal exercise reflects both acute fatigue and non-recovered state in a repeated maximal test setting and may provide complementary information on autonomic and systemic demands when interpreted alongside [Formula: see text], HR, RF and RPE.","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":"5461-5474"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13633992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148367604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-term endurance training in the cold with layered clothing mitigates perceptual strain during exercise in the heat. 在寒冷中穿分层衣服进行短期耐力训练，可以减轻在高温下运动时的感知压力。

IF 2.9 3区医学

European Journal of Applied Physiology Pub Date : 2026-10-01 Epub Date: 2026-07-04 DOI: 10.1007/s00421-026-06319-1

Keiichi Yamaguchi, Saya Okamoto, Akitoshi Makino, Rise Yabuuchi, Olivier Girard, Kazushige Goto

{"title":"Short-term endurance training in the cold with layered clothing mitigates perceptual strain during exercise in the heat.","authors":"Keiichi Yamaguchi, Saya Okamoto, Akitoshi Makino, Rise Yabuuchi, Olivier Girard, Kazushige Goto","doi":"10.1007/s00421-026-06319-1","DOIUrl":"10.1007/s00421-026-06319-1","url":null,"abstract":"Purpose: We examined whether short-term endurance training in the cold combined with layered clothing enhances cardiovascular, thermoregulatory, and performance adaptations.Methods: Sixteen healthy males completed five consecutive days of endurance cycling in the cold (10 °C, 50% relative humidity [rH]) while wearing either thermal layered clothing (WEAR) or light clothing (CON). Before and after training, participants performed a graded exercise test, a time-to-exhaustion test, and a heat stress test (30 min at 35 °C, 50% rH).Results: During training, heart rate, skin temperature, and sweat rate were higher in WEAR than CON (P < 0.05). Maximal power output increased similarly in both groups (WEAR: + 7.2 ± 9.5%; CON: + 8.4 ± 7.1%, P < 0.05), while maximal oxygen uptake improved only in WEAR (52.4 ± 7.3 to 55.2 ± 7.1 mL/kg/min, P < 0.05). During the heat stress test, ratings of perceived exertion and thermal sensation decreased after training in WEAR only (P < 0.05), with no changes in sweat rate, skin temperature, or rectal temperature in either group.Conclusion: Short-term endurance training in the cold combined with layered clothing attenuated perceptual strain during subsequent exercise in the heat, implying a practical alternative approach to traditional heat acclimation strategies.","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":"5543-5552"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13633978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148387481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: The influence of mouth pressure on the cardiovascular response during inspiratory muscle loading at a constant transdiaphragmatic pressure. 校正：在恒定的横膈膜压力下，口压对吸气肌负荷时心血管反应的影响。

IF 2.9 3区医学

European Journal of Applied Physiology Pub Date : 2026-10-01 DOI: 10.1007/s00421-026-06373-9

Megan L Lance, Scott F Thrall, Benjamin P Thompson, Leah M Mann, Jou-Chung Chang, Katherine M Taylor, Nadia M Navarro Solano, Madison J Gorsline, Richard J A Wilson, Trevor A Day, Paolo B Dominelli, Glen E Foster

引用次数: 0

Cyclooxygenase-dependent contribution to increased flow mediated dilatation following a week of repeated ischemic preconditioning. 环氧化酶依赖性对一周反复缺血预处理后血流介导的扩张增加的贡献。

IF 2.9 3区医学

European Journal of Applied Physiology Pub Date : 2026-10-01 Epub Date: 2026-06-29 DOI: 10.1007/s00421-026-06324-4

Samuel Thomas, Sophia R Murphy, Sultan E AlSalahi, Rehan T Junejo

{"title":"Cyclooxygenase-dependent contribution to increased flow mediated dilatation following a week of repeated ischemic preconditioning.","authors":"Samuel Thomas, Sophia R Murphy, Sultan E AlSalahi, Rehan T Junejo","doi":"10.1007/s00421-026-06324-4","DOIUrl":"10.1007/s00421-026-06324-4","url":null,"abstract":"Purpose: Ischemic preconditioning (IPC) and remote ischemic preconditioning (RIPC) independently enhance endothelial function and flow mediated dilation (FMD); yet the underlying mechanisms remain incompletely defined. This study investigated the contribution of cyclooxygenase (COX) dependent vasodilators to FMD before and after repeated IPC and RIPC.Methods: 21 healthy participants underwent Radial artery FMD assessments before and after oral aspirin (600 mg) ingestion for COX inhibition. Participants then completed a one-weeklong alternate day unilateral IPC protocol (four repeated cycles of 5-minute ischemia and 5-minute reperfusion). 24 h after the final IPC session, FMD responses were reassessed before and after aspirin ingestion.Results: Prior to IPC treatment, aspirin failed to significantly reduce FMD in both Radial arteries. Following IPC treatment, the now significantly increased FMD of the ipsilateral arm (9.50 ± 4.58% (mean ± standard deviation); p = 0.006) attenuated with aspirin (4.55 ± 2.68%; p = 0.002). Absolute difference in FMD % before and after aspirin ingestion increased from 1.48 ± 5.05% pre-IPC to 4.95 ± 4.96% (p = 0.016) post-IPC. In the contralateral (RIPC) arm, increased FMD % also attenuated with aspirin (p = 0.006) but this statistical significance was not seen following correction for shear rate. Nonetheless, absolute difference in FMD % before and after aspirin increased from 0.04 ± 4.05 pre-RIPC to 2.27 ± 3.60% (p = 0.043) post-RIPC.Conclusion: One week of alternate day IPC improves contribution of COX-derived vasoactive mediators to FMD. Contributions to RIPC driven improvements in FMD require further investigation.","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":"5281-5291"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13633948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148344216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lung function decline after mountain ultra-marathon is accompanied by reduced inspiratory pressure but not by detectable changes in CC16. 山地超长马拉松后肺功能下降，吸气压力降低，但CC16无明显变化。

IF 2.9 3区医学

European Journal of Applied Physiology Pub Date : 2026-10-01 Epub Date: 2026-07-21 DOI: 10.1007/s00421-026-06349-9

Antoine Raberin, Bastien Krumm, Tom Citherlet, Guia Tagliapietra, Tadej Debevec, Vincent Pialoux, Grégoire P Millet

{"title":"Lung function decline after mountain ultra-marathon is accompanied by reduced inspiratory pressure but not by detectable changes in CC16.","authors":"Antoine Raberin, Bastien Krumm, Tom Citherlet, Guia Tagliapietra, Tadej Debevec, Vincent Pialoux, Grégoire P Millet","doi":"10.1007/s00421-026-06349-9","DOIUrl":"10.1007/s00421-026-06349-9","url":null,"abstract":"Purpose: Mountain ultra-marathons (MUM) impose multiple stressors on pulmonary function inducing risk of airway epithelial damage. This study aimed to assess the magnitude of pulmonary function changes and the associated risks of airway damage induced by such a race.Methods: Thirteen volunteers completed the MUM (330 km, 24,000 m elevation gain). Pulmonary function was assessed using standardized procedures before (pre-) and within 1 h after (post-) the race. Assessments included forced inhalation and exhalation maneuvers, as well as maximal inspiratory pressure (MIP) measurements. Venous blood samples were collected for the analysis of plasma club cell secretory protein 16 (CC16). Blood volume was determined using the carbon monoxide rebreathing method.Results: From pre- to post-, forced vital capacity (FVC) (-7.5%, p = 0.001), forced expiratory volume in 1 s (FEV1) (-12.2%, p = 0.002) and peak expiratory flow (-10.4%, p = 0.016) were reduced. MIP decreased by 14.5% (104 ± 29 vs. 90 ± 26 cmH₂O, p = 0.005). CC16 levels remained unchanged, even after normalization for plasma volume changes (p = 0.929). Slope ratio and β-angle of the maximal expiratory flow-volume curve changes were not significant (p = 0.101 and p = 0.055, respectively). Significant relationships showed that greater decreases in FVC (r = - 0.60, p = 0.026) and FEV₁ (r = - 0.62, p = 0.018) were associated with faster MUM completion times.Conclusion: The acute negative impact of MUM on pulmonary function has been confirmed. The extent of this impairment appears to be proportional to race duration. Biomarker analysis suggests that airway epithelial integrity remains preserved. The reduced pulmonary function could be due to respiratory muscle fatigue.","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":"5595-5605"},"PeriodicalIF":2.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13634006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0