European Journal of Applied Physiology最新文献

{"title":"Effects of arm-cycling exercise during triceps surae neuromuscular electrical stimulation on torque output and fatigue.","authors":"Sami K Alahmari, Lucas B R Orssatto, Anthony J Shield, Gabriel S Trajano","doi":"10.1007/s00421-025-05879-y","DOIUrl":"https://doi.org/10.1007/s00421-025-05879-y","url":null,"abstract":"<p><p>This study compared the responses of arm-cycling during triceps surae neuromuscular electrical stimulation (NMES) on torque-time integral (TTI) and neuromuscular fatigue in healthy young adults. Achilles tendon vibration (VIB) (110 Hz) coupled with wide-pulse (WP) (1 ms) NMES (WP + VIB) of triceps surae alone or in combination with arm-cycling exercise (ARM-CYC) was delivered in two separate sessions in a randomised order (n = 22; 20 men; 29.9 ± 4.4 years). NMES intensity was set to elicit 20% of maximal voluntary isometric contraction (MVC) force. The stimulus pattern was comprised of four sets of 20 repetitions (5 s On and 5 s Off) superimposed to ongoing VIB with a 1-min inter-set interval. Time-torque integral (TTI) was measured for each NMES condition. MVC, voluntary activation level (VAL), peak twitch torque (Peak_twitch), and peak soleus (EMG_SOL), medial (EMG_MG), and lateral gastrocnemius (EMG_LG) electromyography were measured before and immediately after each condition. No significant differences were observed for TTI (P = 0.371) between ARM-CYC and WP + VIB protocols. MVC force and Peak_twitch torque decreased (P < 0.001) immediately after both conditions. No changes were observed for VAL (P = 0.418) and EMG_SOL, EMG_LG, and EMG_MG amplitudes (P = 0.061, 0.484, and 0.135), respectively. Rhythmic arm-cycling in combination with triceps surae NMES did not increase TTI compared to WP + VIB. This was accompanied with similar levels of peripheral fatigue with no indicative of central fatigue across both protocols. The lack of an ARM-CYC effect on torque output likely reflects the low intensity adopted, WP + VIB-induced ceiling effects, and/or enhanced inhibitory input to the triceps surae during combined tasks.</p>","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparable muscle fatigue responses across different low-load blood flow restriction protocols among women.","authors":"Mason A Howard, Paola M Rivera, Sean M Lubiak, Christopher E Proppe, Jeffrey T Schmidt, Ethan C Hill","doi":"10.1007/s00421-025-05878-z","DOIUrl":"https://doi.org/10.1007/s00421-025-05878-z","url":null,"abstract":"<p><strong>Purpose: </strong>Low-load blood flow restricted (LLBFR) resistance exercise has been demonstrated to accelerate acute muscle fatigue, but these responses may be dependent upon the protocol used. The purpose of this investigation was to examine fatigue characteristics following acute LLBFR resistance exercise with a 75-repetition (75-rep; 1 × 30, 3 × 15), 3 sets to failure (3×), and 1 set to failure (1×) protocols.</p><p><strong>Methods: </strong>Sixteen women randomly performed 75-rep, 3× , and 1× LLBFR protocols consisting of unilateral, submaximal (30% of maximal voluntary isometric contraction; [MVIC]), isokinetic (90°·s^-1), leg extension muscle actions. Separate two-way, 3 (Condition [75-rep, 3× , 1×]) × 2 (Time [Pretest, Posttest]), repeated-measure ANOVA models were used to examine MVIC, peak twitch torque (PTT), surface electromyography amplitude (sEMG AMP), voluntary activation (VA), and V_wave/M_wave ratio.</p><p><strong>Results: </strong>There were no significant (p = 0.516-0.984) interactions for any of the fatigue characteristics. Collapsed across Conditions however, MVIC torque (21.1%), PTT (11.0%), sEMG AMP (1.9%), and VA (4.6%) decreased across Time (p < 0.001-0.011). There was no change in V_wave /M_wave ratio (p = 0.639-0.822).</p><p><strong>Conclusions: </strong>Despite differences in set and repetition schemes, all three LLBFR protocols induced comparable decreases in MVIC torque, PTT, sEMG AMP, and VA. The current results highlight the potential efficacy of a single set of LLBFR performed to volitional failure to provoke fatigue responses comparable to multiple set protocols.</p>","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transitioning from stress electrocardiogram to cardiopulmonary exercise testing: a paradigm shift toward comprehensive medical evaluation of exercise function.","authors":"Omri Inbar, Or Inbar, Ron Dlin, Richard Casaburi","doi":"10.1007/s00421-025-05740-2","DOIUrl":"10.1007/s00421-025-05740-2","url":null,"abstract":"<p><p>Cardiopulmonary exercise testing (CPET) has emerged as a powerful diagnostic tool, providing comprehensive physiological insights into the integrated function of cardiovascular, respiratory, and metabolic systems. Exploiting physiological interactions, CPET allows in-depth diagnostic insights. CPET performance entrains several complexities. Interpreting CPET data can be challenging, requiring significant physiological expertise. The advent of artificial intelligence (AI) has introduced a transformative approach to CPET interpretation, enhancing accuracy, efficiency, and clinical decision-making. This review article explores the current state of AI applications in CPET, highlighting AI's potential to replace the traditional stress electrocardiogram (ECG) test as the preferred diagnostic tool in preventive medicine and medical screening. The article discusses the underlying principles of AI, its integration into CPET interpretation, and the associated benefits, including improved diagnostic accuracy, reduced interobserver variability, and expedited decision-making. Additionally, it addresses the challenges and considerations surrounding the implementation of AI in CPET such as data quality, model interpretability, and ethical concerns. The review concludes by emphasizing the significant promise of AI-assisted CPET interpretation in revolutionizing preventive medicine and medical screening settings and enhancing patient care.</p>","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":"1749-1760"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probing gait adaptations: The impact of aging on dynamic stability and reflex control mechanisms under varied weight-bearing conditions.","authors":"Michelle Gwerder, Ursina Camenzind, Samira Wild, Yong K Kim, William R Taylor, Navrag B Singh","doi":"10.1007/s00421-025-05884-1","DOIUrl":"https://doi.org/10.1007/s00421-025-05884-1","url":null,"abstract":"<p><strong>Purpose: </strong>Maintaining stable gait patterns is essential for preserving health and well-being throughout the aging process. While several biomechanical models have been developed to describe gait adaptation and stability, the role of reflex control mechanisms remains underexplored. This study aimed to understand the mechanisms by which disturbances to gait patterns (changes to weight-bearing conditions) are influencing gait adaptations, gait variability, and their underlying reflex control mechanisms during treadmill walking in young and older adults.</p><p><strong>Methods: </strong>Twenty young (mean age 25.7 ± 3.3 years) and 20 older adults (62.3 ± 4.3 years) walked on a treadmill under five weight-bearing conditions: normal bodyweight, 20 and 40% additional weight (bodyweight loading), and 20 and 40% reduced weight (bodyweight unloading). Linear mixed-effects models were used to assess spatiotemporal gait parameters, margin of stability, gait variability (standard deviation), and H-reflex amplitudes.</p><p><strong>Results: </strong>Bodyweight unloading significantly reduced antero-posterior margin of stability (p < 0.01). Compared to young adults, older adults exhibited shorter stride length, longer double-limb support time, larger antero-posterior margin of stability, and increased variability (p < 0.05). While H-reflex amplitudes increased with increasing weight-bearing in young adults, older adults were less capable to modulate their H-reflex amplitude across weight conditions.</p><p><strong>Conclusion: </strong>These findings suggest that gait adaptations under altered weight-bearing conditions involve shifts in temporal gait regulation and gait strategies. The reduced H-reflex modulation in older adults may indicate a limited ability to adapt spinal-level reflex amplitudes, leading to greater reliance on other balance control mechanisms. Understanding these neuromuscular adaptations is essential for designing prevention programs to enhance stability and prevent falls.</p>","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Test-retest reliability of TMS motor evoked responses and silent periods during explosive voluntary isometric contractions.","authors":"F Castelli, O S Mian, A Bruton, A C Valappil, N A Tillin","doi":"10.1007/s00421-025-05707-3","DOIUrl":"10.1007/s00421-025-05707-3","url":null,"abstract":"<p><strong>Purpose: </strong>This study assessed the test-retest reliability of TMS motor evoked potentials (MEPs) and silent periods at early, middle, and late phases of the rising time-torque curve during explosive voluntary contractions. We also investigated how the number of consecutively averaged measurements influenced reliability.</p><p><strong>Methods: </strong>On two separate occasions 3-7 days apart, 14 adults performed several isometric explosive (1-s) contractions of the knee extensors, some of which were superimposed with TMS to elicit MEPs in the superficial quadriceps. Of those with TMS, stimulation was timed to elicit MEPs at either 45 (early), 115 (middle), or 190 ms (late) following contraction onset (16 with-TMS contractions per time condition). TMS was also superimposed at the plateau of 15 separate MVCs. Test-retest intraclass correlation coefficient (ICC) and coefficient of variation (CV) were calculated for MEPs and silent periods consecutively averaged over 3 to 15 separate contractions.</p><p><strong>Results: </strong>No one condition/phase was more reliable than another. For MEP amplitude, in all conditions except the explosive late phase, ICCs generally increased, and CV decreased, with an increase in the number of averaged contractions, and were > 0.50 ICC and < 15% CV within seven contractions. For silent period, ICCs and CVs were unaffected by the number of consecutively averaged contractions and remained > 0.50 ICC and < 10% CV.</p><p><strong>Conclusion: </strong>Test-retest reliability of TMS responses is comparable between phases of explosive contraction and at the plateau of MVC. To maximise reliability of MEPs during explosive contractions or MVCs, we recommend future studies average data across more than the 3-5 contractions typically reported in the literature investigating MEPs at MVC plateau.</p>","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":"1841-1854"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variation of bone-related and inflammatory biomarkers after a half-marathon running in trained subjects.","authors":"C Vassalle, L Sabatino, M Gaggini, F Mastorci, R Ndreu, Fabrizio Minichilli, S Del Turco, E Buzzigoli, A Pingitore","doi":"10.1007/s00421-025-05874-3","DOIUrl":"https://doi.org/10.1007/s00421-025-05874-3","url":null,"abstract":"<p><strong>Background: </strong>Marathons and ultra-marathon generally evidence an anabolic effect on bone metabolism; however, there is scarce knowledge of less demanding events as half-marathons, which, instead, is becoming one of the most popular recreational activities, rising in the number of followers all over the world.</p><p><strong>Aim: </strong>To evaluate the trend of bone turnover biomarkers (bone-specific alkaline phosphatase BALP, osteocalcin OC, type 1 procollagen amino-terminal peptide P1NP, bone formation biomarkers; and carboxy-terminal collagen crosslinks CTx, and bone reabsorption biomarker) and vitamin D (25(OH)D) in controls (CON) with a low physical activity profile and trained runners (ATH; at baseline, after a half-marathon run, and 24-h post), and their correlation with the systemic immune-inflammation index (SII) and other cardiometabolic parameters.</p><p><strong>Results: </strong>ATH showed higher levels of 25(OH)D and bone turnover biomarkers than CON; OC, BALP, P1NP, and CTx significantly increased after post-race (by 18, 20, 14, and 33%, respectively) as compared with baseline, and normalized at 24 h, except for P1NP which slowly decreased at 24 h; SII did not significantly change. In the whole population, all the bone turnover biomarkers were correlated with each other, 25(OH)D correlated with OC and BALP, whereas OC inversely correlated with diastolic blood pressure and 25(OH)D inversely correlated with body mass index. In the ATH group, no correlation between SII concentrations and levels of bone turnover biomarkers was found.</p><p><strong>Conclusion: </strong>Both half-marathon training and acute responses after a running increase bone turnover biomarkers. More data are required to definitively assess if these changes are beneficial or adverse for bone health.</p>","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144539683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EJAP Comment: Is it time to record air quality as an environmental factor in applied physiology studies?","authors":"Stephen J Ives, Oliver E Blum, Justin A DeBlauw","doi":"10.1007/s00421-025-05788-0","DOIUrl":"10.1007/s00421-025-05788-0","url":null,"abstract":"","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":"2027-2029"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hormonal and metabolic responses across phases of combined oral contraceptive use and menstrual cycle in young elite female athletes.","authors":"Katia Collomp, Agnès Olivier, Caroline Teulier, Juliette Bonnigal, Nathalie Crépin, Corinne Buisson, Magnus Ericsson, Emmanuelle Duron, Eric Favory, Mathieu Zimmermann, Virgile Amiot, Carole Castanier","doi":"10.1007/s00421-025-05745-x","DOIUrl":"10.1007/s00421-025-05745-x","url":null,"abstract":"<p><strong>Purpose: </strong>Despite the significant number of female athletes using combined oral contraceptives (COCs), there is scant literature on their hormonal and metabolic effects across different phases.</p><p><strong>Methods: </strong>In order to contribute to a wider knowledge of COC-action mechanisms involved in athletes' performance and health, we therefore examined the effects of low-dose monophasic COC (ethinylestradiol/levonorgestrel) intake on sex hormones (estradiol, progesterone, sex hormone binding protein (SHBG)) as well as on a large number of pituitary (LH, TSH, prolactin) and peripheral (triiodothyronine, cortisol, DHEA, DHEA-S, aldosterone, osteocalcin, 25(OH)D) basal hormone levels in nine young elite female athletes, across COC administration (first and second half of active hormone intake, washout phases), compared to eleven female athletes without hormonal contraception across their normal menstrual cycle (NMC, i.e., early follicular, end follicular/peri-ovulatory, mid-luteal phases).</p><p><strong>Results: </strong>COC vs. NMC increased SHBG (p < 0.01), TSH, cortisol and 25(OH)D (p < 0.05), and decreased DHEA and DHEA-S (p < 0.05) concentrations. Across COC and NMC phases, higher estradiol and aldosterone concentrations (p < 0.05) were observed during the washout and mid-luteal phases, respectively.</p><p><strong>Conclusion: </strong>In highly trained female athletes, COC vs. NMC induced several hormonal alterations, irrespective of the phases, leading to potential ergogenic and clinical repercussions that merit clarification. In NMC athletes, the impact of endogenous sex hormone fluctuations on the parameters studied appeared limited, perhaps mitigated by intense physical training, with only aldosterone change. Given the high prevalence of vitamin D insufficiency, it seems warranted to monitor this parameter, not yet routinely considered in female athletes, taking into account COC intake.</p><p><strong>Trial registration: </strong>ID-RCB:2020-A02965-34, France.</p>","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":"1923-1932"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227346/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143585305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A simple on-field fast knee-flexion test to assess acute knee flexor fatigue.","authors":"Cornelis J de Ruiter, Lucas M Baak, Yfke Westerling, Erik Wilmes","doi":"10.1007/s00421-025-05732-2","DOIUrl":"10.1007/s00421-025-05732-2","url":null,"abstract":"<p><strong>Purpose: </strong>In a practical setting, outside the laboratory, acute muscle fatigue may be underestimated because substantial recovery occurs during the elapsed time between the end of exercise and fatigue assessment. We introduce a simple field test to assess knee flexor contractile function quickly after exercise cessation.</p><p><strong>Methods: </strong>Fourteen young amateur football players performed maximally fast knee flexions (FKFs) in the prone position with their dominant leg, before (pre) and 20 s after finishing a series of fourteen fatiguing 40 m sprints (post) and again following 6 min recovery (rec). Peak angular acceleration (PAA) about the knee joint was measured with a small inertial measurement unit (IMU) firmly attached to the shin.</p><p><strong>Results: </strong>Although participants only practiced the FKFs for 1 min in the warm-up, the reliability of PPA was good with coefficients of variation of 3.0% (pre), 2.7% (post), and 3.6% (rec). Sprint time increased from 5.96 ± 0.40 s to 6.55 ± 0.37 s (p < 0.001, f = 0.89), PAA decreased from 107.1 ± 11.5 rad.s^-2 to 94.1 ± 11.7 rad.s^-2 (p < 0.001, f = 0.50) and following recovery (p < 0.05) values were 6.15 ± 0.39 s and 103.1 ± 10.7 rad.s^-2, respectively. The percentage decrease in PAA during FKFs was linearly related (r² = 0.48, p = 0.01) to the percentage increase in 40 m sprint time. In addition, PAA (pre) was related to the time of the first sprint (r² = 0.33, p = 0.03).</p><p><strong>Conclusion: </strong>The proposed FKF test is reliable and can easily be executed to evaluate acute knee flexor muscle fatigue on the field. The presented relations between (changes in) sprint performance and peak knee angular accelerations during isolated fast knee flexions are promising but need confirmation in larger-scaled studies.</p>","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":"1961-1969"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227368/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor control performance-related modulation of beta-band EEG-sEMG coherence differs between general and local muscular exercise-induced fatigue.","authors":"Changxiao Yu, Jianglong Zhan, Linfeng Xu, Junhong Zhou, Weijie Fu","doi":"10.1007/s00421-025-05714-4","DOIUrl":"10.1007/s00421-025-05714-4","url":null,"abstract":"<p><strong>Purpose: </strong>Exercise-induced fatigue can reduce motor control performance and increase the risk of sporting injuries, which are related to functional coupling within the corticomotoneuronal pathway. However, the differences in functional coupling caused by general and local muscular exercise-induced fatigue are unknown. This study aimed to investigate the effects of exercise-induced fatigue on the beta-band (16-30 Hz) functional coupling between the sensorimotor cortex (SM1) and muscles of the dominant lower limb under different fatigue protocols.</p><p><strong>Methods: </strong>Twenty-four healthy male participants were recruited to participate in randomized sessions of personalized constant speed running as general muscular exercise (GME) and maximum isokinetic ankle plantar-dorsiflexion as local muscular exercise (LME) to induce fatigue. These sessions were separated by 7 days. The electroencephalogram (EEG) signals of SM1 (e.g., FC1, FCz, and Cz) and surface electromyography signals (sEMG) of four muscles (soleus, SOL; medial gastrocnemius, MG; later gastrocnemius, and LG; tibialis anterior, TA) were simultaneously recorded before and after fatigue during the ankle plantar-dorsiflexion task, which were used for beta-band coherence analyses.</p><p><strong>Results: </strong>Following fatigue induced by GME, the EEG-sEMG coherence was significantly greater than that induced by LME (P < 0.04). Compared to pre-fatigue state, the coherence of FC1-SOL, FCz-SOL, and Cz-SOL increased significantly after general fatigue, while these coherences decreased significantly after local fatigue.</p><p><strong>Conclusion: </strong>Fatigue induced by GME indicates an enhancement in beta-band functional coupling between the SM1 and muscles of the dominant lower limb, which is related to higher motor control performance. In contrast, fatigue induced by LME diminishes the functional coupling.</p>","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":"1869-1879"},"PeriodicalIF":2.8,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}