Hannah J Coyle-Asbil, Mirko Brandes, Berit Brandes, Christoph Buck, Marvin N Wright, Lori Ann Vallis
{"title":"Evaluating machine learning approaches to predict the energy expenditure of cross-national preschool children: a study of preprocessing and feature effects.","authors":"Hannah J Coyle-Asbil, Mirko Brandes, Berit Brandes, Christoph Buck, Marvin N Wright, Lori Ann Vallis","doi":"10.1007/s00421-025-05800-7","DOIUrl":"10.1007/s00421-025-05800-7","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to examine the impact of preprocessing and inclusion of various features on predicting the energy expenditure (EE) of preschool children (3.0-6.99 years).</p><p><strong>Methods: </strong>The internal Canadian sample consisted of 36 children, equipped with accelerometers on their wrists (OPAL) and right hip (ActiGraph GT9X). The external German sample consisted of 41 children, equipped with accelerometers on their wrists (GENEActiv) and right hip (GENEActiv; ActiGraph GT3X +). Both datasets used portable metabolic units to record EE. The effects of filtering, rectifying, adding a time delay, frequency domain (FD) features, and participant features on EE prediction across linear regression, random forest (RF), and fully connected neural network models. The Canadian sample was split into training (2/3) and validation (1/3) sets, and the German sample served as an external validation set.</p><p><strong>Results: </strong>Consistently it was found that the RF with filtered, not rectified data with FD, participant features, and a time delay resulted in improved performance compared to approaches used previously. The models also performed similarly in the holdout sample but resulted in higher error when applied in the external validation dataset.</p><p><strong>Conclusions: </strong> Results attest that filtering, not rectifying, FD features and participant features result in improved model performance to predict the EE of preschool children.</p>","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":"2985-2998"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The cross-over effects of unilateral resistance exercise in trained males and females.","authors":"Joshua C Carr, Caleb C Voskuil, Monique D Dudar","doi":"10.1007/s00421-025-05998-6","DOIUrl":"https://doi.org/10.1007/s00421-025-05998-6","url":null,"abstract":"<p><strong>Purpose: </strong>To identify the cross-over effects on maximal contralateral force and muscle excitability following fatiguing unilateral resistance exercise of the lower and upper limbs in chronically trained participants.</p><p><strong>Methods: </strong>Two crossover experiments using a within-subject, time-matched control design examined the contralateral responses on maximal force and muscle excitability in the elbow flexors (Experiment 1, resistance-trained, n = 20) and knee extensors (Experiment 2, endurance-trained, n = 23). Participants performed unilateral resistance exercise (four sets to task failure) while contralateral assessments were collected and compared to a no-exercise control condition.</p><p><strong>Results: </strong>Contralateral elbow flexor, but not knee extension, force declined over time (p < 0.01, ηₚ<sup>2</sup> = 0.116), but was not influenced by visit (p = 0.563, ηₚ<sup>2</sup> < 0.01) or sex (p = 0.779, ηₚ<sup>2</sup> < 0.01), indicating no added effect of unilateral fatiguing exercise. Muscle excitability showed a significant effect for sex, with females maintaining higher excitability than males (p < 0.01, d = 0.420). Biceps brachii excitability showed a decline during the control visit only, while rectus femoris and vastus lateralis showed reduced excitability post-exercise compared to control (p < 0.05, d = 0.600-1.02).</p><p><strong>Discussion: </strong>These findings suggest that acute unilateral resistance exercise does not compromise nor enhance contralateral force in trained individuals. However, alterations in maximal muscle excitability despite maintained force imply rapid contralateral neuromuscular adaptations within the input-output properties of muscle excitation and force. These results suggest differential susceptibility to cross-over effects across limbs and between sexes following unilateral resistance exercise.</p>","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prolonged running reduces speed at the moderate-to-heavy intensity transition without additional reductions due to increased eccentric load.","authors":"Andrew M S Barrett, Ed Maunder","doi":"10.1007/s00421-025-05792-4","DOIUrl":"10.1007/s00421-025-05792-4","url":null,"abstract":"<p><strong>Aim: </strong>To investigate the impact of prolonged running on speed at the moderate-to-heavy intensity transition, and whether increased eccentric load modifies exercise-induced shifts in the moderate-to-heavy intensity transition.</p><p><strong>Methods: </strong>Twelve endurance-trained runners (4 females, 8 males, peak oxygen uptake 51.5 mL kg<sup>-1</sup> min<sup>-1</sup> in females and 56.1 mL kg<sup>-1</sup> min<sup>-1</sup> in males) participated. Following trials to assess speed at the first ventilatory threshold (VT<sub>1</sub>) on a 0% gradient and -10% gradient, participants completed two trials: (i) level trial (LVL): 120-min of running at 0% gradient and (ii) downhill trial (DH): 120-min of running with 90-min at 0% gradient and 6 × 5-min intervals at -10% gradient (DH). Running was conducted at 90% of VT<sub>1</sub> speed for respective gradients. Speed at VT<sub>1</sub> on 0% gradient, perceived leg muscle soreness, and maximal voluntary isometric knee extensor torque were assessed pre- and post-prolonged exercise.</p><p><strong>Results: </strong>An effect of time was observed for speed at VT<sub>1</sub> (∆-6.2 ± 3.6% in LVL and ∆-7.6 ± 3.2% in DH, P < 0.001), with no effect of condition (LVL vs. DH, P = 0.382), or time × condition interaction (P = 0.295). Reduced metabolic energy expenditure (metabolic power) significantly contributed to the reduced speed at VT<sub>1</sub> in both trials (P < 0.001), whereas changes in running economy (energetic efficiency) did not (P = 0.228).</p><p><strong>Conclusion: </strong>Prolonged moderate-intensity running reduced speed at the moderate-to-heavy intensity transition, but this was not exacerbated by increased eccentric load. Reduced speed at the moderate-to-heavy intensity transition following prolonged running was primarily attributed to decreased metabolic power.</p>","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":"2897-2910"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lars Erik Gjerløw, Arnstein Sunde, Eva Maria Støa, Jan Helgerud, Jan-Michael Johansen, Henrik Hjortland, Øyvind Støren
{"title":"Determining physiologic variables for changes in 800-m running and 800-m ski ergometer performance.","authors":"Lars Erik Gjerløw, Arnstein Sunde, Eva Maria Støa, Jan Helgerud, Jan-Michael Johansen, Henrik Hjortland, Øyvind Støren","doi":"10.1007/s00421-025-05765-7","DOIUrl":"10.1007/s00421-025-05765-7","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates associations between changes in 800 m time trial performance in running or ski ergometer double poling, and changes in physiologic variables after a seven-week observational period. Forty six athletes ranging from recreational to elite level, participated in either a run (RUN) or a ski ergometer (SKI) observational study.</p><p><strong>Methods: </strong>The participants performed pre- and post-tests in; 800-m time trial (800TT), 100-m time trial (MSS or MSP), peak oxygen uptake (VO<sub>2peak</sub>), oxygen cost of running (C<sub>R</sub>) or double poling (C<sub>DP</sub>), time to exhaustion (TTE) at 130% maximal aerobic speed (MAS) or maximal aerobic power (MAP), and maximal accumulated oxygen deficit (MAOD) in SKI. They also performed one repetition maximum (1RM), half-squat (RUN) or 1RM lat pull-down (SKI).</p><p><strong>Results: </strong>Moderate correlations were found between changes in both MAP and maximal strength and changes in 800TT for SKI (r = - 0.51 and r = - 0.51, respectively, p < 0.05). For RUN, MAS and the 0.8 MAS + 0.2 MSS equation correlated (r = - 0.71 and r = - 0.73, respectively, p < 0.01) with 800TT. VO<sub>2peak</sub> was the most important contributor to MAS improvements (RUN) while C<sub>DP</sub> was the most important contributor to MAP improvements (SKI). No correlations were found between changes in TTE at 130% MAS or MAP and, or MAOD, and changes in 800TT, for neither RUN nor SKI. The results from the present study suggest focusing on training to improve maximal oxygen uptake (VO<sub>2max</sub>), work economy and maximal sprint speed to improve performance in middle-distance running and ski sprinting.</p>","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":"2805-2821"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12479658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"What it means to be 'neuromuscular': toward more appropriate use of the term in applied exercise and sport science research involving healthy participants.","authors":"Steven J O'Bryan, Dale M Harris","doi":"10.1007/s00421-025-06007-6","DOIUrl":"https://doi.org/10.1007/s00421-025-06007-6","url":null,"abstract":"","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The preventive effects of exercise on renal dysfunction in D-galactose treated rats: the role of miR-296-5p and SGLT2.","authors":"Maryamossadat Mirtajaddini Goki, Farzaneh Rostamzadeh, Saeideh Jafarinejad-Farsangi, Elham Jafari, Zahra Soltani, Sobhan Mansouri, Hesam Askarimoghadam","doi":"10.1007/s00421-025-06005-8","DOIUrl":"https://doi.org/10.1007/s00421-025-06005-8","url":null,"abstract":"<p><strong>Purpose: </strong>The prevalence of kidney diseases increases with diabetes and aging. Alterations in sodium-glucose transporters-2 (SGLT2) levels in the proximal tubule are associated with diabetes. This study evaluated effects of moderate-intensity endurance training (MIET) and high-intensity interval training (HIIT) on miR-296-5p expression, which acts as an upstream regulator of SGLT2 mRNA translation, as well as SGLT2 mRNA and protein levels in the kidney tissue of male Wistar rats during aging progression.</p><p><strong>Methods: </strong>Concurrently with D-galactose (D-gal) injection, rats in the exercise groups underwent either MIET or HIIT. Histopathological indices and fibrosis were assessed using H&E and Masson's trichrome staining in six groups: CTL, CTL + MIET, CTL + HIIT, D-gal, D-gal + MIET, and D-gal + HIIT. The expression levels of miR-296-5p and SGLT2 mRNA were quantified by real-time PCR, while SGLT2 protein expression was determined via western blot analysis. Serum levels of creatinine, BUN, and glucose were determined via photometric methods.</p><p><strong>Results: </strong>Both MIET and HIIT reduced glomerulosclerosis in D-gal-treated rats. Expression of miR-296-5p increased in both CTL and D-gal groups in response to MIET and HIIT. SGLT2 protein levels were elevated in the D-gal group compared to CTL controls. Both MIET and HIIT decreased SGLT2 protein levels in CTL and D-gal groups. Moreover, HIIT normalized serum creatinine and BUN levels in D-gal-treated animals.</p><p><strong>Conclusion: </strong>MIET and HIIT modulate SGLT2 mRNA expression and protein levels by upregulating miR-296-5p. The reduction in SGLT2 levels is associated with decreased glucose uptake and improved kidney structure and function.</p>","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yu-Hua Chang, Mei-Hsuan Wu, Kuei-Fu Lin, Kok-Hwa Tan
{"title":"Correction: Effects of 12-week free sprint training and speed, agility, and quickness training (SAQT) on reaction time and lower limb muscle activation during crouch start.","authors":"Yu-Hua Chang, Mei-Hsuan Wu, Kuei-Fu Lin, Kok-Hwa Tan","doi":"10.1007/s00421-025-05964-2","DOIUrl":"https://doi.org/10.1007/s00421-025-05964-2","url":null,"abstract":"","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sebastian Hacker, Claudia Lenz, Lukas Reichert, Robert Ringseis, Karen Zentgraf, Karsten Krüger
{"title":"Correction: Vitamin D status and its determinants in German elite athletes.","authors":"Sebastian Hacker, Claudia Lenz, Lukas Reichert, Robert Ringseis, Karen Zentgraf, Karsten Krüger","doi":"10.1007/s00421-025-05965-1","DOIUrl":"https://doi.org/10.1007/s00421-025-05965-1","url":null,"abstract":"","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}