European Journal of Neuroscience最新文献

{"title":"Red Clover Supplementation Alleviates Neurological Deficits in Estrogen Deficient Rats Exposed to Chronic Unpredictable Mild Stress","authors":"Neha Goyal,&nbsp;Rishabh Chaudhary,&nbsp;Khushboo Aggarwal,&nbsp;Harish Kumar,&nbsp;Nitin Bansal,&nbsp;Sumeet Gupta,&nbsp;Seema Bansal","doi":"10.1111/ejn.70164","DOIUrl":"https://doi.org/10.1111/ejn.70164","url":null,"abstract":"<div>\u0000 \u0000 <p>Estrogen deficiency after menopause contributes to various neurological disorders, including stress, anxiety, depression, and memory impairment. Hormone replacement therapy (HRT) is commonly used to mitigate menopausal symptoms, but its use is associated with significant adverse effects. As a result, phytoestrogens, plant-derived estrogens structurally similar to HRTs, are preferred alternatives due to their lack of side effects associated with synthetic HRTs. Among these phytoestrogens, red clover (RC) has emerged as a potent medicinal herb used for the treatment of menopausal symptoms. Thus, the aim of the current study was to evaluate the effects of RC on neurological disorders in estrogen-deficient rats subjected to chronic unpredictable mild stress (CUMS). Ovariectomy (OVX) was performed to induce estrogen deficiency, a condition that closely mimics menopause in females. CUMS, a model of chronic stress, was employed to mimic the stress and anxiety that commonly accompany menopause. Significant changes in physiological, neurobehavioral, biochemical, molecular, and histopathological alterations in the brain hippocampal region were observed in OVX, CUMS, and OVX + CUMS group rats, indicating enhanced neuronal deficits compared with control group rats. Treatment with RC supplementation, 17-β estradiol (E2), and fluoxetine (Flx) significantly restored the pathological alterations caused by both CUMS and estrogen deficiency toward normal. E2 and Flx were included in the study to serve as established treatments for postmenopausal symptoms and stress-related disorders, providing a basis for comparison with RC. In conclusion, our study demonstrated the immense potential of RC in alleviating neurological disorders associated with estrogen deficiency and chronic stress.</p>\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 12","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repetition Hampers Flexible Object Manipulation Under Visual Uncertainty","authors":"Catherine Anne Sager,&nbsp;Ian Greenhouse,&nbsp;Michelle Marneweck","doi":"10.1111/ejn.70155","DOIUrl":"https://doi.org/10.1111/ejn.70155","url":null,"abstract":"<p>Seemingly simple actions, like reaching for and lifting an object, involve the coordination of distinct neural pathways within the dorsal and ventral streams. These components can be differentially affected by repetition-induced anterograde interference, where extensive practice on one task impairs performance on subsequent tasks. Repetition leads to rigid movement patterns, making it harder to adapt flexibly to new situations, especially in tasks with sensory uncertainty that require the brain to rely more on past experiences (i.e., sensorimotor memories). To explore this, we tested whether object-use tasks, which depend on the ventral stream, are more affected by this interference than a simpler reach-to-button task with helpful visual cues. Participants completed two tasks: a reach-to-button task involving pressing buttons on either side of a symmetrical object and an object-use task where the same object had a hidden, asymmetric center of mass (CoM). To measure interference, we manipulated how many times participants lifted the object with the weight on one side before switching it to the other side. Our results showed that interference was strongest in the object-use task, where uncertain visual information forced participants to rely on sensorimotor memories. In contrast, the reach-to-button task, supported by helpful visual cues, showed no significant interference. This suggests that tasks relying on the ventral stream are more vulnerable to interference, particularly when sensory feedback is unclear. Our findings highlight how repetition affects different movement types and emphasize the need for a balance between repetition and flexibility in motor learning.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 12","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG Correlates of Auditory Short-Term Memory and Dissimilarity Perception in Young and Older Adults","authors":"M. Costa,&nbsp;P. Vuust,&nbsp;M. L. Kringelbach,&nbsp;L. Bonetti","doi":"10.1111/ejn.70166","DOIUrl":"https://doi.org/10.1111/ejn.70166","url":null,"abstract":"<p>Understanding the neural correlates of short-term memory is crucial, particularly in the context of aging. In this electroencephalography (EEG) study, we investigated the impact of aging on the brain activity underlying short-term memory and perception of dissimilarity of auditory sequences. Fifty-four participants were divided into two groups: (i) 29 young adults (20–30 years old) and (ii) 25 older adults (60–80 years old). We used a variation of the same/different task employing pairs of tone sequences and asking participants to rate the degree of dissimilarity of the second sequence in comparison to the first one. Sequences could be either identical (same), totally different, or with transposed tones. Behavioral results showed a lower level of perceived dissimilarity in different sequences in older compared to young adults. The memory task induced a fronto-central negative slow wave (NSW) that was significantly higher in the 20–30 group for all three conditions. NSW was higher in the same than in the different and transposed conditions but only in young adults. In transposed sequences, NSW amplitude was modulated by the perception of dissimilarity. The P50 component to first sound of the second sequence was significantly higher in older adults. The N1 was more negative in the same than in the different and transposed conditions. The P2 was higher in the same than in the transposed condition.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 12","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70166","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Environmental and Genetic Influences on Developmental Outcomes Across the Domains of Language, Cognition, Motor Function, and Social Behavior","authors":"Marta Schiavon,&nbsp;Birgitte K. Burton,&nbsp;Nicoline Hemager,&nbsp;Aja N. Greve,&nbsp;Katrine S. Spang,&nbsp;Ditte Ellersgaard,&nbsp;Kerstin Jessica Plessen,&nbsp;Jens Richardt M. Jepsen,&nbsp;Anne A. E. Thorup,&nbsp;Thomas Werge,&nbsp;Merete Nordentoft,&nbsp;Ron Nudel","doi":"10.1111/ejn.70163","DOIUrl":"https://doi.org/10.1111/ejn.70163","url":null,"abstract":"<p>Linguistic, motor, cognitive, and social-behavioral functions are fundamental facets of a child's neurodevelopment and are influenced by both genetic factors and environmental factors, such as the home environment, including the parents' mental health. However, the nature of these influences remains largely unknown. Using a genotyped cohort of 391 7-year-old children with comprehensive phenotype data on linguistic, motor, cognitive, and social-behavioral performance as well as data on parental mental health and the home environment, we performed regression analyses for the individual neurodevelopmental domains and principal components (PCs) capturing the variance across all domains simultaneously, where these outcomes were regressed on a polygenic score for educational attainment (PGS for EA) as a proxy for genetic factors and the Home Observation for Measurement of the Environment (HOME) as a proxy for environmental factors. HOME was significantly associated with all domains; the PGS for EA was nominally significantly associated (<i>p</i> ≤ 0.05) with cognitive function only. In the principal component analysis, PC1 and PC2 captured 52.57% and 20.73% of the variance in our phenotypic data, respectively. HOME was significantly associated only with PC1, while the PGS for EA was significantly associated only with PC2. Significant differences between familial risk groups were observed for PC1. Our results suggest an important role for potentially modifiable environmental factors on child neurodevelopment across multiple domains. We identified two orthogonal dimensions capturing parts of phenotypic variance that were associated with either environmental or genetic factors, but not both, providing insight into the interplay between genes and the environment in neurodevelopment.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 12","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70163","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144300446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Equitable Research Funding: Strategies, Challenges and the Role of Funding Agencies","authors":"Sarah Ruediger,&nbsp;Laurence Ris,&nbsp;Keerthana Iyer","doi":"10.1111/ejn.70160","DOIUrl":"https://doi.org/10.1111/ejn.70160","url":null,"abstract":"<p>Ensuring equitable access to research funding is crucial for fostering diversity, innovation and excellence in science. Despite progress, significant disparities remain, with underrepresented researchers—including women, racial and ethnic minorities, LGBTQIA+ individuals and those with disabilities—continuing to receive disproportionately less funding. These disparities not only hinder individual careers but also limit the breadth of perspectives that drive scientific discovery. Through discussions with major funding agencies, including the Dana Foundation, European Research Council (ERC) and ERA-NET NEURON, we examine how equity, diversity and inclusion (EDI) are integrated into research funding allocation. We focus on three key areas: (1) How EDI is defined and prioritised (2) metrics for assessing and tracking progress and (3) strategies for mitigating bias in selection procedures. While agencies have implemented initiatives such as demographic data transparency, targeted funding mechanisms and bias-awareness training, systemic challenges remain. Variability in data collection practices, barriers in peer review processes and limitations of interventions like double-blind reviews highlight the need for ongoing reform. As EDI policies face growing political scrutiny and active efforts to dismantle existing frameworks, reinforcing and expanding strategies to ensure equitable funding distribution has never been more critical. The scientific community must continue advocating for evidence-based approaches that improve transparency, accountability and fairness in research funding. Without sustained commitment, the progress made over the past decades is at risk of being reversed, undermining the diversity of thought and innovation essential to scientific advancement.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70160","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repetitive Magnetic Stimuli Over the Motor Cortex Impair Consolidation of a Balance Task by Suppressing Up-Regulation of Intracortical Inhibition","authors":"Sven Egger,&nbsp;Michael Wälchli,&nbsp;Samuel Meyer,&nbsp;Wolfgang Taube","doi":"10.1111/ejn.70161","DOIUrl":"https://doi.org/10.1111/ejn.70161","url":null,"abstract":"<div>\u0000 \u0000 <p>Low-frequency repetitive transcranial magnetic stimulation (rTMS) over the primary motor cortex (M1) was shown to impair short-term consolidation of a balance task, emphasizing the importance of M1 in balance skill consolidation. However, the disruptive mechanisms of rTMS on neural consolidation processes and their persistence across multiple balance acquisition sessions remain unclear. GABAergic processes are crucial for motor consolidation and, at the same time, are up-regulated when learning balance skills. Therefore, this study investigated the impact of rTMS on GABA-mediated short-interval intracortical inhibition (SICI) and consolidation of balance performance. Participants (<i>n</i> = 31) underwent six balance acquisition sessions on a rocker board, each followed by rTMS (<i>n</i> = 15) or sham-rTMS (<i>n</i> = 16). In the PRE-measurement, SICI was assessed at baseline and after balance acquisition with subsequent rTMS/sham-rTMS. In the POST-measurement, this procedure was repeated to assess the influence of motor memory reactivation on SICI. In addition, SICI-PRE and SICI-POST were compared to assess longer-term processes. Both groups achieved similar improvements within the balance acquisition sessions. However, they did not consolidate equally well, indicated by significant declines in performance for the rTMS group (<i>p</i> = 0.003) in the subsequent sessions. Adaptations in SICI were affected by rTMS (<i>p</i> = 0.024): while the sham-rTMS group up-regulated SICI, rTMS led to reductions in inhibition. The interfering effect of rTMS on both balance consolidation and up-regulation of SICI suggests that increased intracortical inhibition is an important factor to protect and consolidate the newly acquired motor memory.</p>\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144256032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-Specific Adaptations to VTA Circuits Following Subchronic Stress","authors":"Chloé Bouarab,&nbsp;Megan Wynalda,&nbsp;Brittney V. Thompson,&nbsp;Ambika Khurana,&nbsp;Caitlyn R. Cody,&nbsp;Alexandre Kisner,&nbsp;Abigail M. Polter","doi":"10.1111/ejn.70153","DOIUrl":"https://doi.org/10.1111/ejn.70153","url":null,"abstract":"<div>\u0000 \u0000 <p>Dysregulation of the mesolimbic reward circuitry is implicated in the pathophysiology of stress-related illnesses such as depression and anxiety. These disorders are more frequently diagnosed in females, and sex differences in the response to stress are likely to be one factor that leads to enhanced vulnerability of females. In this study, we use subchronic variable stress (SCVS), a model in which male and female mice exhibit distinct behavioral, transcriptional, and immunological alterations, to investigate sexually divergent mechanisms of regulation of the ventral tegmental area by stress. Using slice electrophysiology, we find that female, but not male, mice have a reduction in the ex vivo firing rate of VTA dopaminergic neurons following SCVS. Surprisingly, both male and female animals show an increase in inhibitory tone onto VTA dopaminergic neurons and an increase in the firing rate of VTA GABAergic neurons. In males, however, this is accompanied by a robust increase in excitatory synaptic tone onto VTA dopamine neurons. This supports a model by which SCVS recruits VTA GABA neurons to inhibit dopaminergic neurons in both male and female mice, but males are protected from diminished functioning of the dopaminergic system by upregulation of excitatory synapses. Thus, SCVS leads to both shared and disparate changes in the organization of the VTA in males and females.</p>\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144244557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Structural Brain Networks in Psychopathy and Its Relation to Externalizing Behaviors","authors":"Peiyang Guo,&nbsp;Cheng Cheng,&nbsp;Xiangyi Zhang","doi":"10.1111/ejn.70158","DOIUrl":"https://doi.org/10.1111/ejn.70158","url":null,"abstract":"<div>\u0000 \u0000 <p>Externalizing behaviors are particularly pronounced in the context of psychopathy. Recent neurobiological models suggest that psychopathy may be associated with abnormalities in brain network connectivity, which could contribute to its development and its links to externalizing behaviors. However, the specific structural networks contributing to psychopathy and its relation to externalizing behaviors remain poorly understood. In this study, we investigated the structural connectivity associated with psychopathy and its relation to externalizing behaviors in 82 young adults from the MPI Leipzig Mind-Brain–Body dataset. A structural connectome–based prediction model with leave-one-out cross-validation identified both positive and negative networks associated with psychopathy. Specifically, the positive network involved regions related to social-affective processing, language, and reward systems, while the negative network was associated with regions involved in attention modulation. Furthermore, mediation analyses revealed two potential neural pathways from psychopathic traits to externalizing behaviors via emotional processing and attention modulation networks. These findings suggest that alterations in structural connectivity play a significant role in psychopathy and may underlie the externalizing behaviors observed in individuals with the disorder.</p>\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144232484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Activation and Functional Connectivity During Performance of Lumbopelvic Motor Tasks in Individuals With and Without Low Back Pain: A Functional Magnetic Resonance Imaging Study","authors":"Max K. Jordon,&nbsp;Sheri P. Silfies,&nbsp;Paul F. Beattie,&nbsp;Jennifer M. C. Vendemia,&nbsp;Jill Campbell Stewart","doi":"10.1111/ejn.70154","DOIUrl":"https://doi.org/10.1111/ejn.70154","url":null,"abstract":"<div>\u0000 \u0000 <p>Mounting evidence suggests that individuals with chronic low back pain exhibit changes in brain activity. However, changes in brain activity during the performance of salient motor tasks have not been fully described. Therefore, the purpose of this study was to investigate the differences in cortical activation and functional connectivity between individuals with and without chronic low back pain while performing condition-specific motor tasks. Twenty-three individuals with chronic low back pain and 19 asymptomatic individuals participated in this study. Whole brain activity and functional connectivity were measured, whereas participants performed three lumbopelvic motor tasks: modified bilateral bridge, left unilateral bridge, and right unilateral bridge. Whole-brain analysis revealed no significant differences in brain activation between the groups when performing lumbopelvic motor tasks. An exploratory region of interest analysis demonstrated that individuals with chronic low back pain had significantly higher activation in the left insular-opercular cortex, left midcingulate gyrus, right insular-opercular cortex, right midcingulate gyrus, and right putamen. Functional connectivity analysis revealed significantly higher connectivity between the midcingulate gyrus, putamen, and insular-opercular cortex in those with chronic low back pain compared to asymptomatic participants. Taken together, this study helps build on the existing literature by providing unique insights into the changes that occur during the performance of salient motor tasks in individuals with chronic low back pain.</p>\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144220184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Neuroscience Has Changed—or Not?","authors":"Marian Joëls","doi":"10.1111/ejn.70152","DOIUrl":"https://doi.org/10.1111/ejn.70152","url":null,"abstract":"&lt;p&gt;Earlier this year, Floyd E. Bloom (1936–2025) passed away. Floyd Bloom was an excellent neuroscientist (Bloom &lt;span&gt;2011&lt;/span&gt;) who added seminal contributions to our understanding of how transmitters, peptides, and alcohol affect brain function. His role in a well-known textbook on neuropharmacology (Cooper et al. &lt;span&gt;2003&lt;/span&gt;) caused my generation to recognize his name immediately. Among the many honorous positions he held, his presidency of the Society for Neuroscience and a position as Editor-in-Chief of the journal &lt;i&gt;Science&lt;/i&gt; stand out. As a former postdoctoral fellow in his research team, I got to know Floyd Bloom as a generous mentor, a highly efficient worker with an almost encyclopedic knowledge, and, most of all, a person with a great sense of humor.&lt;/p&gt;&lt;p&gt;The sad event made me muse about how neuroscience has changed over the past 30 years. Of course, our understanding of the brain has greatly advanced, as has the technology. Whereas life cell imaging was state of the art in 1995, these days, a full chemo- and optogenetic toolbox is at our disposal, and whole-brain single-cell transcriptomics is feasible. Neuroscience is exciting, though it has become complex.&lt;/p&gt;&lt;p&gt;The complexity of today's neuroscience is also apparent from the publication characteristics. Comparing a set of publications in the &lt;i&gt;European Journal of Neuroscience&lt;/i&gt; from 1995 (volume 7, issues 1–6; see Supporting Information for more details) and 2024 (volume 59) shows that the average number of displays per se has not increased. However, a hidden increase is evident from the Supporting Information, which did not yet exist in 1995 (Figure 1A). The number of authors per publication has expanded, as has the number of affiliations and countries per study. All in all, this supports the idea that a bigger team is necessary to come to a single publication.&lt;/p&gt;&lt;p&gt;Interestingly, although the &lt;i&gt;EJN&lt;/i&gt; predominantly published work from European labs in 1995, it has evolved into a more global journal (Figure 1B). For instance, almost 20% of the publications in the 2024 volume had a corresponding author with a Chinese affiliation, as opposed to none in 1995. The percentage of women, either overall, as first author, or as corresponding author, has increased. Based on the increased participation of women in the neuroscience workforce, one can extrapolate the numbers from 1995 and predict those of 2024 (see Supporting Information for details). The predicted values for the overall percentage of female authors (42%) and the percentage of female first authors (54%) are very comparable to the actual percentages in 2024 (42% and 51%, respectively). The actual percentage of female corresponding authors (44%) is somewhat lower than the predicted number (51%), but still substantial. Overall, the contribution of women to &lt;i&gt;EJN&lt;/i&gt; publications nowadays is close to par with that of men.&lt;/p&gt;&lt;p&gt;Job done? Not if we look at the numbers in &lt;i&gt;Science&lt;/i&gt;, the journal where Floyd B","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 11","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70152","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144213773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}