European Journal of Neuroscience最新文献

Electroencephalography (EEG) and the Quest for an Inclusive and Global Neuroscience

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-18 DOI: 10.1111/ejn.70078

Faisal Mushtaq, Agustín Ibáñez

{"title":"Electroencephalography (EEG) and the Quest for an Inclusive and Global Neuroscience","authors":"Faisal Mushtaq, Agustín Ibáñez","doi":"10.1111/ejn.70078","DOIUrl":"https://doi.org/10.1111/ejn.70078","url":null,"abstract":"<p>The current lack of diversity in neuroimaging datasets limits the potential generalisability of research findings. This situation is also likely to have a downstream impact on our ability to translate fundamental research into effective interventions and treatments for the global population. We propose that electroencephalography (EEG) is viable for delivering truly inclusive and global neuroscience. Over the past two decades, advances in portability, affordability, and computational sophistication have created a tool that can readily reach underrepresented communities and scale across low-resource contexts—advantages that surpass those of other neuroimaging modalities. However, skepticism persists within the neuroscience community regarding the feasibility of realizing EEG's full potential for studying the brain on a global scale shortly. We highlight several challenges impeding progress, including the need to amalgamate large-scale, harmonized datasets to provide the statistical power and robust computational frameworks necessary for examining subtle differences between populations; the advancement of EEG technology to ensure high-quality data acquisition from all individuals—irrespective of hair type—and operable by nonspecialists; and the importance of engaging directly with communities to cocreate culturally sensitive and ethically appropriate research methodologies. By tackling these technical and social challenges and building on initiatives dedicated to inclusivity and collaboration, we can harness EEG's potential to deliver neuroscience genuinely representative of the global population.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 6","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70078","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modularity Measures of Functional Brain Networks Predict Individual Differences in Long-Term Memory

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-17 DOI: 10.1111/ejn.70052

Michael B. Zhou, Marvin M. Chun, Qi Lin

{"title":"Modularity Measures of Functional Brain Networks Predict Individual Differences in Long-Term Memory","authors":"Michael B. Zhou, Marvin M. Chun, Qi Lin","doi":"10.1111/ejn.70052","DOIUrl":"https://doi.org/10.1111/ejn.70052","url":null,"abstract":"<div>\u0000 \u0000 <p>Long-term memory (LTM) is crucial to daily functioning, and individuals show a wide range in LTM capacity. In this study, we ask: How does the brain's functional organization explain individual differences in LTM? We focused on two important, widely studied forms of LTM, general recognition and recollection memory. Inspired by recent work on graph theory and modularity of the brain, we explored how modularity measures of brain activity during encoding could predict individual differences in later LTM performance. Specifically, we examined two modularity measures that describe distinct aspects of network functioning: diversity—the extent a node connects with different modules—and locality—the extent a node has more connections within its own modules. Combining modularity measures and connectome-predictive modeling (CPM), a powerful framework for predicting individual differences in behavior from brain functional connectivity, we found that diversity and locality measures together significantly predicted individual differences in both general recognition and recollection memory. Modularity-based predictions were less strong than CPM models using only connectivity features. With regard to predictive neuroanatomy, we found that the default mode network was the most consistently selected brain network across our models. Our findings extend previous work on how the modularity of the brain is related to cognition and demonstrate that successful LTM is supported by critical connector hubs coordinating between and within networks during encoding. More broadly, they demonstrate the utility of a graph-based approach to reveal how modularity of brain networks relates to individual differences in LTM.</p>\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 6","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathological Mechanisms of Irradiation-Induced Neurological Deficits in the Developing Brain 辐照诱发发育中大脑神经缺陷的病理机制

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-17 DOI: 10.1111/ejn.70070

Seidu A. Richard

{"title":"Pathological Mechanisms of Irradiation-Induced Neurological Deficits in the Developing Brain","authors":"Seidu A. Richard","doi":"10.1111/ejn.70070","DOIUrl":"https://doi.org/10.1111/ejn.70070","url":null,"abstract":"<div>\u0000 \u0000 <p>Cranial irradiation or radiotherapy (CRT) is one of the essential therapeutic modalities for central nervous system (CNS) tumors, and its efficacy is well known. Nevertheless, CRT is also associated with brain damages such as focal cerebral necrosis, neuroinflammation, cerebral microvascular anomalies, neurocognitive dysfunction, and hormone deficiencies in children. Children's brains are much more sensitive to CRT compared to the adult's brains. Thus, children's brains are also more likely to develop long-term CRT complication, which severely lessens their long-term quality of life after treatment. CRT to the juvenile rat led to a retardation of growth of the cerebellum; both the gray and white matter and neurogenic regions like the subventricular zone and the dentate gyrus in the hippocampus were predominantly vulnerable to CRT. Also, CRT-induced cognitive changes typically manifested as deficits in hippocampal-related functions of learning as well as memory, such as spatial information processing. Fractionated CRT–stimulated cognitive decline and hormone deficiencies were precisely associated with augmented neuronal cell death, blockade of neurogenesis, and stimulation of astrocytes and microglia. Thus, the aim of this review is to highlight the pathological mechanism of CRT-induced neurological deficits in the developing brain.</p>\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 6","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Progression of Cortical Layer 6 Input to First-Order Thalamic Nuclei and the Thalamic Reticular Nucleus During Postnatal Development

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-17 DOI: 10.1111/ejn.70073

Guela Sokhadze, Gubbi Govindaiah, Peter Campbell, William Guido

{"title":"Progression of Cortical Layer 6 Input to First-Order Thalamic Nuclei and the Thalamic Reticular Nucleus During Postnatal Development","authors":"Guela Sokhadze, Gubbi Govindaiah, Peter Campbell, William Guido","doi":"10.1111/ejn.70073","DOIUrl":"https://doi.org/10.1111/ejn.70073","url":null,"abstract":"<div>\u0000 \u0000 <p>One of the largest excitatory projections to the thalamus arises from Layer 6 (L6) neurons of the neocortex. As corticothalamic (CT) projections descend, they pass through the thalamic reticular nucleus (TRN), forming collateral connections with GABAergic neurons, which provide feedback inhibition onto thalamocortical neurons. This arrangement allows for modulation of thalamocortical signalling in a modality-specific and state-dependent manner. Little is known about how L6 projections make functional connections with neurons in TRN and thalamic nuclei during development. We used an L6-specific mouse line (<i>Ntsr1-Cre</i>) crossed onto Cre-dependent reporters to examine when L6 CT axons innervate and form functional connections in TRN, as well as first-order nuclei including the ventrobasal complex (VB) and dorsal lateral geniculate nucleus (dLGN). In <i>Ntsr1-Cre::Ai9</i> mice, tdTomato-labelled CT axons were present in TRN and latero-ventral VB at postnatal day (P)2–3. By P7, CT fibers occupied all of VB and began to innervate the ventral half of dLGN and eventually progressed dorsally to encompass dLGN by P12–14. Using optogenetics in acute slice recordings in <i>Ntsr1-Cre::Ai32</i> mice showed that excitatory postsynaptic responses followed a similar sequence, first appearing in TRN (P7), then in VB (P7–10), and lastly in dLGN (P10–14). Initially, responses were weak and failed to follow low rates of repetitive stimulation. As the incidence of responses increased with age, so did synaptic strength, with responses to stimulus trains showing synaptic facilitation. These studies suggest that L6 cortical innervation of the thalamus is highly coordinated, with connections in TRN maturing prior to those in first-order nuclei.</p>\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 6","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143638881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene Therapy Targeting GD3 Synthase Protects Against MPTP-Induced Parkinsonism and Executive Dysfunction

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-16 DOI: 10.1111/ejn.70061

Panchanan Maiti, Yi Xue, Tonia S. Rex, Michael P. McDonald

{"title":"Gene Therapy Targeting GD3 Synthase Protects Against MPTP-Induced Parkinsonism and Executive Dysfunction","authors":"Panchanan Maiti, Yi Xue, Tonia S. Rex, Michael P. McDonald","doi":"10.1111/ejn.70061","DOIUrl":"https://doi.org/10.1111/ejn.70061","url":null,"abstract":"<div>\u0000 \u0000 <p>More than half of Parkinson's patients exhibit fronto-striatally mediated executive dysfunction, including deficits in sustained attention, judgment, and impulse control. We have previously shown that modification of brain gangliosides by targeted deletion of GD3 synthase (GD3S) is neuroprotective in vivo and in vitro. The objective of the present study was to determine whether GD3S knockdown will protect neurons and prevent executive dysfunction following a subchronic regimen of 25-mg/kg 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). C57BL/6N wild-type mice were assessed on a battery of sensorimotor tasks and a reaction-time task that included measures of sustained attention and impulse control. Sustained attention was measured by response accuracy and reaction time; impulsivity was measured by premature responding in the response holes or the food well during the precue period. After reaching stable performance, mice received intrastriatal injections of a recombinant adeno-associated viral (AAV) vector expressing a short-hairpin RNA (shRNA) construct targeting <i>St8sia1</i>, the gene that codes for GD3S, or a scrambled-sequence control (scrRNA). After 4 weeks, mice received MPTP or saline injections. MPTP-lesioned mice in the scrRNA control group exhibited loss of impulse control in the sessions following MPTP injections, compared to the other three groups. These deficits abated with extended training but re-emerged on challenge sessions with shorter cue durations or longer precue durations. GD3S knockdown partially protected nigrostriatal neurons from MPTP neurotoxicity and prevented the motor impairments (coordination, bradykinesia, fine motor skills) and loss of impulse control. Our data suggest that inhibition of GD3S warrants further investigation as a novel therapeutic strategy for Parkinson's disease.</p>\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 6","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuropeptide-Dependent Spike Time Precision and Plasticity in Circadian Output Neurons

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-13 DOI: 10.1111/ejn.70037

Bryan Chong, Vipin Kumar, Dieu Linh Nguyen, Makenzie A. Hopkins, Faith S. Ferry, Lucia K. Spera, Elizabeth M. Paul, Anelise N. Hutson, Masashi Tabuchi

{"title":"Neuropeptide-Dependent Spike Time Precision and Plasticity in Circadian Output Neurons","authors":"Bryan Chong, Vipin Kumar, Dieu Linh Nguyen, Makenzie A. Hopkins, Faith S. Ferry, Lucia K. Spera, Elizabeth M. Paul, Anelise N. Hutson, Masashi Tabuchi","doi":"10.1111/ejn.70037","DOIUrl":"https://doi.org/10.1111/ejn.70037","url":null,"abstract":"<p>Circadian rhythms influence various physiological and behavioral processes such as sleep–wake cycles, hormone secretion, and metabolism. In <i>Drosophila</i>, an important set of circadian output neurons is called pars intercerebralis (PI) neurons, which receive input from specific clock neurons called DN1. These DN1 neurons can further be subdivided into functionally and anatomically distinctive anterior (DN1a) and posterior (DN1p) clusters. The neuropeptide diuretic hormones 31 (Dh31) and 44 (Dh44) are the insect neuropeptides known to activate PI neurons to control activity rhythms. However, the neurophysiological basis of how Dh31 and Dh44 affect circadian clock neural coding mechanisms underlying sleep in <i>Drosophila</i> is not well understood. Here, we identify Dh31/Dh44-dependent spike time precision and plasticity in PI neurons. We first find that a mixture of Dh31 and Dh44 enhanced the firing of PI neurons, compared to the application of Dh31 alone and Dh44 alone. We next find that the application of synthesized Dh31 and Dh44 affects membrane potential dynamics of PI neurons in the precise timing of the neuronal firing through their synergistic interaction, possibly mediated by calcium-activated potassium channel conductance. Further, we characterize that Dh31/Dh44 enhances postsynaptic potentials in PI neurons. Together, these results suggest multiplexed neuropeptide-dependent spike time precision and plasticity as circadian clock neural coding mechanisms underlying sleep in <i>Drosophila</i>.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Incentive Cocaine-Seeking Habits and Their Compulsive Manifestation Emerge After a Downregulation of the Dopamine Transporter in Astrocytes Across Functional Domains of the Striatum

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-13 DOI: 10.1111/ejn.70054

Maxime Fouyssac, Tristan Hynes, Aude Belin-Rauscent, Dhaval D. Joshi, David Belin

{"title":"Incentive Cocaine-Seeking Habits and Their Compulsive Manifestation Emerge After a Downregulation of the Dopamine Transporter in Astrocytes Across Functional Domains of the Striatum","authors":"Maxime Fouyssac, Tristan Hynes, Aude Belin-Rauscent, Dhaval D. Joshi, David Belin","doi":"10.1111/ejn.70054","DOIUrl":"https://doi.org/10.1111/ejn.70054","url":null,"abstract":"<p>The development of compulsive cue-controlled-incentive drug-seeking habits is a hallmark of substance use disorder that is predicated on an intrastriatal shift in the locus of control over behaviour from a nucleus accumbens (Nac) core–dorsomedial striatum network to a Nac core–anterior dorsolateral striatum (aDLS) network. This shift is paralleled by drug-induced (including cocaine) dopamine transporter (DAT) alterations originating in the ventral striatum that spread eventually to encompass the aDLS. Having recently shown that heroin self-administration results in a pan-striatal reduction in astrocytic DAT that precedes the development of aDLS dopamine-dependent incentive heroin-seeking habits, we tested the hypothesis that similar adaptations occur following cocaine exposure. We compared DAT protein levels in whole tissue homogenates, and in astrocytes cultured from ventral and dorsal striatal territories of drug-naïve male Sprague–Dawley rats to those of rats with a history of cocaine taking or an aDLS dopamine-dependent incentive cocaine-seeking habit. Cocaine exposure resulted in a decrease in whole tissue and astrocytic DAT across all territories of the striatum. We further demonstrated that compulsive (i.e., punishment-resistant) incentive cocaine-seeking habits were associated with a reduction in DAT mRNA levels in the Nac shell, but not the Nac core-aDLS incentive habit system. Together with the recent evidence of heroin-induced downregulation of striatal astrocytic DAT, these findings suggest that alterations in astrocytic DAT may represent a common mechanism underlying the development of compulsive incentive drug-seeking habits across drug classes.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70054","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dysregulation of MicroRNA Biogenesis Machinery in Nervous System Diseases

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-13 DOI: 10.1111/ejn.70058

Terence Duarte, Diane Meyre Rassi, Andrea Carvalho, Douglas Elias Santos, Sonia Zanon, Guilherme Lucas

{"title":"Dysregulation of MicroRNA Biogenesis Machinery in Nervous System Diseases","authors":"Terence Duarte, Diane Meyre Rassi, Andrea Carvalho, Douglas Elias Santos, Sonia Zanon, Guilherme Lucas","doi":"10.1111/ejn.70058","DOIUrl":"https://doi.org/10.1111/ejn.70058","url":null,"abstract":"<div>\u0000 \u0000 <p>MicroRNAs (miRNAs) have become essential modulators in many brain disorders, such as neurodegenerative diseases, psychiatry disorders, and chronic pain syndromes, and they play a critical role in controlling gene expression. This review investigates how disorders of the nervous system and pain research are affected by malfunctions in the miRNA biogenesis machinery. Despite tremendous progress, we still do not fully understand how these molecular regulators affect neuropathological processes. Even with the increasing amount of research, little is known about the malfunctions of the miRNA machinery, especially when it comes to the nervous system and the diseases that are linked to it. The results of recent research are compiled in this review, which emphasizes the role that disruptions in miRNA processing enzymes, including Drosha, Dicer, Argonaute, and RISC proteins, play in neurological conditions like Parkinson's and Alzheimer's diseases, as well as more general neurodegeneration. We also go over current studies on the stimulus-dependent, temporal, and spatial expression patterns of these essential miRNA biogenesis components in pain. These discoveries broaden our knowledge of the fundamental processes behind pain-related illnesses and present prospective directions for focused therapeutic approaches.</p>\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anatomically Veridical On-Scalp Sensor Topographies

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-13 DOI: 10.1111/ejn.70060

Nicholas A. Alexander, Johan Medrano, Robert A. Seymour, Stephanie Mellor, George C. O’Neill, Meaghan E. Spedden, Tim M. Tierney, Eleanor A. Maguire

{"title":"Anatomically Veridical On-Scalp Sensor Topographies","authors":"Nicholas A. Alexander, Johan Medrano, Robert A. Seymour, Stephanie Mellor, George C. O’Neill, Meaghan E. Spedden, Tim M. Tierney, Eleanor A. Maguire","doi":"10.1111/ejn.70060","DOIUrl":"https://doi.org/10.1111/ejn.70060","url":null,"abstract":"<p>When working with sensor-level data recorded using on-scalp neuroimaging methods such as electroencephalography (EEG), it is common practice to use two-dimensional (2D) representations of sensor positions to aid interpretation. Positioning of sensors relative to anatomy, as in the classic 10–20 system of EEG electrode placement, enables the use of 2D topographies that are familiar to many researchers and clinicians. However, when using another increasingly popular on-scalp neuroimaging method, optically pumped magnetometer–based magnetoencephalography (OP-MEG), bespoke sensor arrays are much more common, and these are not prepared according to any standard principle. Consequently, polar projection is often used to produce individual sensor topographies that are not directly related to anatomy and cannot be averaged across people simply. Given the current proliferation of OP-MEG facilities globally, this issue will become an increasing hindrance when visualising OP-MEG data, particularly for group studies. To address this problem, we adapted and extended the 10–20 system to build a flexible, anatomical projection method applied to digitised head shape, fiducials and sensor positions. We demonstrate that the method maintains spatially veridical representations across individuals improving on standard polar projections at varying OPM sensor array densities. By applying our projection method, the benefits of anatomically veridical 2D topographies can now be enjoyed when visualising data, such as those from OP-MEG, regardless of variation in sensor placement as in sparse or focal arrays.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143622745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Complexity Theory in Understanding Brain's Neuron–Glia Interactions

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-12 DOI: 10.1111/ejn.70050

M. Di Chiano, P. Milior, Y. Poulot-Becq-Giraudon, R. Lanfredini, G. Milior

{"title":"The Role of Complexity Theory in Understanding Brain's Neuron–Glia Interactions","authors":"M. Di Chiano, P. Milior, Y. Poulot-Becq-Giraudon, R. Lanfredini, G. Milior","doi":"10.1111/ejn.70050","DOIUrl":"https://doi.org/10.1111/ejn.70050","url":null,"abstract":"<p>Brain information processing complexity is conventionally recognized as derived from neuronal activity, with neurons and their dynamic signalling responsible for the transfer and processing of information. However, the brain also contains other non-neuronal cells, glial cells, which exceed the number of neurons and are involved in the processes related with information coding by neural networks and underlying brain functions. Decisive advances in the characterization of the molecular and physiological properties of glial cells shed light on their active roles in neurotransmission and neuronal physiopathology. This expanded relationship between neurons and glia challenges traditional neurobiology by highlighting their reciprocal influence, where it is difficult to determine whether neuronal or glial processes initiate and drive the interactions. This interplay creates a dilemma, where the causal hierarchy between these two cell types remains unresolved. A philosophical tool, the ‘Theory of Complexity’ of Edgard Morin can help to better explain and study the complexity of neuron–glia interactions. Morin's proposal on complexity is useful to transform brain knowledge, in order to review the brain molecular functions in antireductionist pattern. In this manuscript, we will discuss how to use the ‘retroactive loop’ principle from Morin's ‘Theory of Complexity’ at the brain molecular level, proposing a new philosophical-experimental grid that can help neuroscientists for a better understanding of the glia–neuron interactions in the brain.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143602822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0