European Journal of Neuroscience最新文献_第2页

Modeling the Influence of Circadian Rhythm on Ionic Dynamics and the Effect of Antiepileptic Drugs 模拟昼夜节律对离子动力学的影响及抗癫痫药物的作用。

IF 2.4 4区医学

European Journal of Neuroscience Pub Date : 2025-09-30 DOI: 10.1111/ejn.70265

Dlima Nesrine, Carrere Marcel, Bedoui Mohamed Hedi, Damien Depannemaecker

引用次数: 0

N170 Amplitude to Rare Neutral Faces in an Oddball Condition Reflects Prediction Error 奇异条件下N170对稀有中性面孔的振幅反映了预测误差

IF 2.4 4区医学

European Journal of Neuroscience Pub Date : 2025-09-30 DOI: 10.1111/ejn.70264

Xinyang Liu, Xueqiao Li, Piia Astikainen

{"title":"N170 Amplitude to Rare Neutral Faces in an Oddball Condition Reflects Prediction Error","authors":"Xinyang Liu, Xueqiao Li, Piia Astikainen","doi":"10.1111/ejn.70264","DOIUrl":"https://doi.org/10.1111/ejn.70264","url":null,"abstract":"Visual mismatch negativity (vMMN) of event-related potentials (ERPs) reflects automatic change detection in serially presented stimuli under the predictive coding framework. Previous studies have shown modulations of P1 and N170 components in response to changes in facial expressions, though these studies have not fully controlled for stimulus probability and low-level visual features. We recorded P1 and N170 to facial expressions and investigated their associations to vMMN in 36 participants of wide age range (19–65 years, M = 46.19, SD = ±13.07) and varying levels of depressive symptoms (Beck's Depression Index-II, M = 15.06, SD = ±12.43). Neutral, happy, and sad faces were assigned as deviant (pdeviant = 0.14) and standard stimuli in separate oddball conditions allowing comparison of responses to physically identical stimuli in the deviant and standard positions. A control condition with seven basic facial expressions (p = 0.14 for each) and no repetitive stimuli served as a control for predictive processing. We found evidence of predictive deviance detection in face processing, indicated in the N170 amplitude, but only for neutral faces (deviant > standard and deviant > control). Depressive symptoms did not correlate with ERP amplitudes or latencies, while the N170 amplitude increased with age. These findings suggest that, under conditions controlling for low-level features and stimulus probability, prediction error is robustly indexed by N170 amplitude in response to neutral faces. No such effects were observed for emotional (happy or sad) faces, or in earlier ERPs (P1) or latency measures.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"62 7","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70264","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145197333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Cognitive Reserve on Lateralization of EEG Phase-Locking Responses During Working Memory Tasks 工作记忆任务中认知储备对脑电锁相反应偏侧化的影响。

IF 2.4 4区医学

European Journal of Neuroscience Pub Date : 2025-09-28 DOI: 10.1111/ejn.70261

Rümeysa Duygun, Petunia Reinke, Sebastian Ocklenburg, Bahar Güntekin

{"title":"The Impact of Cognitive Reserve on Lateralization of EEG Phase-Locking Responses During Working Memory Tasks","authors":"Rümeysa Duygun, Petunia Reinke, Sebastian Ocklenburg, Bahar Güntekin","doi":"10.1111/ejn.70261","DOIUrl":"10.1111/ejn.70261","url":null,"abstract":"<div>\u0000 \u0000 Cognitive reserve (CR), shaped by the interaction of lifestyle and genetics, enhances the efficient use of neural resources, allowing individuals with higher reserve to require less neural activity to accomplish a task than those with lower reserve. Although not solely a mechanism for neural efficiency, hemispheric asymmetries contribute to it through the lateralization of cognitive processes across hemispheres. It is hypothesized that CR may influence the degree of asymmetry in neural activity during various cognitive processes. The aims of this study were to explore the effects of CR on verbal and visuospatial working memory performance and its relationship with the degree of asymmetry in 2–9 Hz phase-locking responses. The data were collected in two separate laboratories: one in Turkey and one in Germany. The sample included 33 Turkish and 18 German participants, all of whom completed verbal and visuospatial Sternberg tasks at two difficulty levels (one-item and three-item). The behavioral performance parameter was d' value, with EEG asymmetry calculated via the laterality coefficient (LC) formula. Under conditions of increased task difficulty, the LCs in the verbal task and CR scores had significant associations, especially in the parietal electrode pairs. Similarly, the LCs in the visuospatial task had significant associations with CR scores in the parietal and occipital electrode pairs. Furthermore, phase-locking responses were significantly higher in the right hemisphere across both tasks. These findings suggest that CR influences neural asymmetry, emphasizing the right hemisphere's role in CR and its potential as a therapeutic target.\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"62 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145185098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Slow-Oscillatory Transcranial Alternating Current Stimulation Over the Primary Motor Cortex Improves Motor Skill Acquisition 慢振荡经颅交流电刺激初级运动皮层改善运动技能习得

IF 2.4 4区医学

European Journal of Neuroscience Pub Date : 2025-09-26 DOI: 10.1111/ejn.70269

Shota Miyaguchi, Yasuto Inukai, Kanta Igarashi, Shunpei Yamamoto, Naofumi Otsuru, Hideaki Onishi

{"title":"Slow-Oscillatory Transcranial Alternating Current Stimulation Over the Primary Motor Cortex Improves Motor Skill Acquisition","authors":"Shota Miyaguchi, Yasuto Inukai, Kanta Igarashi, Shunpei Yamamoto, Naofumi Otsuru, Hideaki Onishi","doi":"10.1111/ejn.70269","DOIUrl":"https://doi.org/10.1111/ejn.70269","url":null,"abstract":"Slow-oscillatory brain activity (< 4 Hz) is crucial in memory consolidation and motor performance. Although transcranial alternating current stimulation (tACS) can modulate cortical oscillatory activity and influence motor learning, the effects of slow oscillation modulation via tACS remain unclear. This study investigated the effects of 0.75-Hz tACS applied to the primary motor cortex (M1) on the acquisition and retention of a visuomotor tracking task. Fifty-four right-handed healthy adults (mean age: 21.2 ± 0.6 years) were assigned to one of three groups: M1-tACS, Cz-tACS, or sham. In the M1-tACS and sham groups, electrodes were placed over the right M1 and left supraorbital ridge. In the Cz-tACS group, electrodes were placed over the Cz (International 10–20 system) and left supraorbital ridge to assess site specificity. tACS was administered for 30 min at 0.75 Hz and 1.0 mA, while participants practiced the visuomotor task. A retention test was conducted the following day. Motor learning was assessed using the power approximation index from the learning curve and error rates. The M1-tACS group showed a significantly lower approximation index than the sham group (p = 0.033), indicating enhanced learning. Error rates immediately after practice and on the following day were also significantly lower in the M1-tACS group (p = 0.039 and p = 0.007, respectively). No significant differences were found in the Cz-tACS group. These results suggest that slow-oscillatory tACS targeting the M1 facilitates motor skill acquisition and retention, with effects specific to the hand area of M1.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"62 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70269","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Involvement of Perimovement Neural Beta-Oscillations in Strategic Aiming for Motor Adaptation 周围运动神经振荡参与运动适应策略瞄准

IF 2.4 4区医学

European Journal of Neuroscience Pub Date : 2025-09-26 DOI: 10.1111/ejn.70260

Matthias Will, Betina Korka, Max-Philipp Stenner

{"title":"Involvement of Perimovement Neural Beta-Oscillations in Strategic Aiming for Motor Adaptation","authors":"Matthias Will, Betina Korka, Max-Philipp Stenner","doi":"10.1111/ejn.70260","DOIUrl":"https://doi.org/10.1111/ejn.70260","url":null,"abstract":"Humans rely on cognitive strategies to adapt upcoming movement in response to past movement error, for example, by strategic reaiming. We show that strategy-based motor adaptation engages premovement and postmovement neural oscillations in the beta frequency band. We recorded electroencephalography (EEG) while healthy participants (N = 27) performed center-out reaching movements to move a cursor on a screen through a visual target. In some trials (17%), the cursor was unexpectedly rotated relative to the hand. This rotation was either repeated in the next trial, so that participants could reaim their reach in that trial (2× condition), or the rotation was switched off, preventing reaiming (1× condition; within-subject design). We found a stronger decrease in postmovement beta rebound (PMBR) after the first rotation in the 2× condition, compared to the 1× condition, despite similar movement kinematics. This indicates a role of PMBR in strategic reaiming, and replicates findings from our previous study (Korka et al., 2023). Combining data from the two studies (total N = 52), we found that reaiming accuracy was associated with premovement beta power in the second rotated trial, but not with the PMBR decrease at the end of the first rotated trial. Our results indicate that the decrease in PMBR upon movement error signals the need to adjust a cognitive strategy. Such a role may explain how reduced PMBR in Parkinson's disease could impair discovery of cognitive strategies for movement. Premovement beta power, on the other hand, may be involved in the specification of an aiming strategy following erroneous movement.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"62 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70260","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Task Relevance Modulates Somatosensory Awareness Depending on Stimulus Intensity 任务相关性根据刺激强度调节躯体感觉意识

IF 2.4 4区医学

European Journal of Neuroscience Pub Date : 2025-09-25 DOI: 10.1111/ejn.70262

Alice Giorgi, Erica Bonomi, Enrico Salemi, Davide Albertini, Flavia Maria Zauli, Ezequiel Pablo Mikulan, Andrea Pigorini, Pietro Avanzini, Maria Del Vecchio

{"title":"Task Relevance Modulates Somatosensory Awareness Depending on Stimulus Intensity","authors":"Alice Giorgi, Erica Bonomi, Enrico Salemi, Davide Albertini, Flavia Maria Zauli, Ezequiel Pablo Mikulan, Andrea Pigorini, Pietro Avanzini, Maria Del Vecchio","doi":"10.1111/ejn.70262","DOIUrl":"https://doi.org/10.1111/ejn.70262","url":null,"abstract":"Recent studies on somatosensory evoked potentials (SEPs) have proposed that the P3b component reflects higher order postperceptual processes, such as stimulus reporting and task relevance, whereas somatosensory awareness negativity (SAN) is more directly associated with somatosensory awareness. Despite growing evidence supporting this functional distinction, the omission of no-report conditions and controls for task demands hindered a clear separation between report- and task-related processes from those linked with somatosensory awareness. Here, we designed a simple experimental procedure that varied stimulus amplitude (set at individual sensory or motor thresholds) and task relevance (no-report stimulation, report + task-relevant stimuli, report + task-irrelevant stimuli) with two main objectives: first, to verify that P3b appears only when a report is required, being abolished in a no-report condition, and second, to determine the extent to which SAN is modulated by task requirements and stimulation amplitude. Our results closely link P3b with task relevance and show that SAN is indeed modulated by task relevance but only when stimuli are delivered at the verge of detection. In other words, task relevance influences conscious perception through an enhancement of the associated neural responses but only for stimuli challenging to detect. Overall, our findings provide evidence that P3b is closely associated with task relevance, remaining out of the correlates of sensory awareness. In parallel, SAN modulations serve as a useful proxy for awareness in experimental manipulations involving attentional factors but only when stimuli are delivered near the sensory threshold.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"62 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70262","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145146508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Directionality of Interpersonal Neural Influence in Functional Near-Infrared Spectroscopy Hyperscanning: Feasibility of Information–Theoretic Causality Analysis in Motor Tasks 功能性近红外光谱超扫描中人际神经影响的方向性：运动任务信息论因果分析的可行性。

IF 2.4 4区医学

European Journal of Neuroscience Pub Date : 2025-09-24 DOI: 10.1111/ejn.70252

Maha Shadaydeh, Vanessa Noering, Marcel Franz, Tara Chand, Ilona Croy, Joachim Denzler

{"title":"Directionality of Interpersonal Neural Influence in Functional Near-Infrared Spectroscopy Hyperscanning: Feasibility of Information–Theoretic Causality Analysis in Motor Tasks","authors":"Maha Shadaydeh, Vanessa Noering, Marcel Franz, Tara Chand, Ilona Croy, Joachim Denzler","doi":"10.1111/ejn.70252","DOIUrl":"10.1111/ejn.70252","url":null,"abstract":"Hyperscanning approaches mark a shift from single- to two-person neuroscience, enabling a more profound understanding of the neural mechanisms underlying interpersonal synchronization. In this context, functional near-infrared spectroscopy (fNIRS) has emerged as a valuable tool for measuring brain activity in a natural, unconstrained environment. While interpersonal synchrony using fNIRS hyperscanning has been well-studied using statistical association analysis, establishing causal relationships that elucidate the direction of influence remains challenging. This study aimed to investigate the feasibility of determining the direction of influence in dyadic interactions. Since the ground truth of such direction is not available in a natural setting, we validated our approach in an experimental setup in which we controlled the direction of influence between two subjects by assigning them the roles of “Model” and “Imitator” of specified motor tasks. A total of 22 participants, hence 11 dyads, completed the task in a within-subject design. We adapted concepts from spectral causal effect decomposition theories to formulate a new measure of the direction and intensity of influence. The results demonstrate that the direction of influence in fNIRS data can be detected with an accuracy in the range of 62%–71%. Furthermore, the proposed spectral causality measure was shown to significantly reduce spurious causal relationships due to the confounding effects of physiological processes and measurement artifacts compared to time domain causal analysis.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"62 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70252","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual Beauty Assessment Scale: Psychometric Validation of Italian and English Versions 视觉美评定量表：意、英两种版本的心理测量验证。

IF 2.4 4区医学

European Journal of Neuroscience Pub Date : 2025-09-24 DOI: 10.1111/ejn.70259

Marco Iosa, Claudia Salera, Gabriella Antonucci, Daniela De Bartolo

{"title":"Visual Beauty Assessment Scale: Psychometric Validation of Italian and English Versions","authors":"Marco Iosa, Claudia Salera, Gabriella Antonucci, Daniela De Bartolo","doi":"10.1111/ejn.70259","DOIUrl":"10.1111/ejn.70259","url":null,"abstract":"Since ancient times, philosophers and researchers have attempted to define beauty. In recent years, psychologists have distinguished between subjective and objective beauty, as well as between emotional and cognitive dimensions. However, a psychometrically validated tool for assessing beauty is still lacking. The aim of the present study was to develop and validate the Visual Beauty Assessment Scale (Vi-BAS). Across three experiments, 18 items were generated based on participants' definition of beauty (Experiment 1), and their validity and reliability were assessed in Italian native speakers (Experiment 2) and English native speakers (Experiment 3). Exploratory factorial analysis (EFA) was conducted in Experiment 2 to identify latent variables, which were confirmed in Experiment 3. Results identified four latent variables of beauty—subjective, objective, emotional, and cognitive—each represented in the Vi-BAS by two valid and reliable items, for a total of eight items. An average Vi-BAS score was also validated. This study introduces a comprehensive scale for assessing different dimensions of beauty, demonstrating validity and reliability both in Italian and English.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"62 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70259","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Childhood Attention Hyperactivity Disorder on Cognitive Function in Adult Obsessive-Compulsive Disorder Patients: A Comprehensive Study 儿童注意多动障碍对成人强迫症患者认知功能影响的综合研究。

IF 2.4 4区医学

European Journal of Neuroscience Pub Date : 2025-09-23 DOI: 10.1111/ejn.70245

Ibrahim Dursun, Aysegul Kirkas, Hasan Bakay, Mehmet Sinan Iyisoy, Sakir Gica

{"title":"The Impact of Childhood Attention Hyperactivity Disorder on Cognitive Function in Adult Obsessive-Compulsive Disorder Patients: A Comprehensive Study","authors":"Ibrahim Dursun, Aysegul Kirkas, Hasan Bakay, Mehmet Sinan Iyisoy, Sakir Gica","doi":"10.1111/ejn.70245","DOIUrl":"10.1111/ejn.70245","url":null,"abstract":"<div>\u0000 \u0000 Studies evaluating cognitive functions in patients with obsessive-compulsive disorder (OCD) have yielded inconsistent results in various cognitive domains. One key reason for contradictory findings is the frequent occurrence of comorbid psychiatric disorders in OCD. Attention deficit hyperactivity disorder (ADHD), especially in childhood, is one of the most common comorbidities in OCD. The aim of the current study was to identify potential differences in cognitive functions caused by childhood ADHD in adult OCD patients while minimizing the effects of symptoms that frequently accompany OCD, such as anxiety, depression, and age. The study included 35 OCD patients with childhood ADHD (OCD + cADHD), 44 OCD patients without childhood ADHD (OCD–cADHD), and 40 healthy controls (HC). Hamilton Depression and Anxiety Scales were applied to all participants. Next, the Cambridge Neuropsychological Test Automated Battery (CANTAB) [Paired-Associate-Learning (PAL), Cambridge Gambling Task (CGT), Stop Signal Test (SST), and Intra-/Extra–Dimensional Set-Shifting Test (IED)] was administered. The OCD patients without childhood ADHD (OCD − cADHD) exhibited higher mean scores in CGT-Risk-Taking and Bet Ratio compared to the HC. However, OCD patients with childhood ADHD (OCD + cADHD) also showed higher mean scores in CGT-Bet Ratio compared to the HC. The mean number of IED-Total Errors and IED-Total Trials was higher in the OCD + cADHD group compared to the HC. The OCD + cADHD group had a higher mean number of SST-Direction Errors and Missed Trials than other groups. The results of the current study suggest that even when potential confounding factors such as depression and anxiety are neutralized, the presence of childhood ADHD in adult patients with OCD led to differences in cognitive domains related to decision-making, flexible thinking, and impulsivity.\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"62 6","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal Flexibility in Associative Memory: Insights From Synaptic Tagging and Capture 联想记忆的时间灵活性：来自突触标记和捕获的见解

IF 2.4 4区医学

European Journal of Neuroscience Pub Date : 2025-09-22 DOI: 10.1111/ejn.70258

Amrita Benoy, Dorothy Tse

引用次数: 0