European Journal of Neuroscience最新文献_第3页

Aging in Autism: An Event-Related Potentials Study of Auditory Change Detection. 自闭症的衰老：听觉变化检测的事件相关电位研究。

IF 2.5 4区医学

European Journal of Neuroscience Pub Date : 2026-10-01 DOI: 10.1111/ejn.70719

Marine Bessé, Shasha Morel-Kohlmeyer, Emmanuelle Houy-Durand, Philippe Prévost, Laurie Tuller, Badiâa Bouazzaoui, Laurence Taconnat, Julia Capdeville, Lucie Angel, Marie Gomot

{"title":"Aging in Autism: An Event-Related Potentials Study of Auditory Change Detection.","authors":"Marine Bessé, Shasha Morel-Kohlmeyer, Emmanuelle Houy-Durand, Philippe Prévost, Laurie Tuller, Badiâa Bouazzaoui, Laurence Taconnat, Julia Capdeville, Lucie Angel, Marie Gomot","doi":"10.1111/ejn.70719","DOIUrl":"https://doi.org/10.1111/ejn.70719","url":null,"abstract":"Autistic individuals are often thought to exhibit reduced tolerance for change, which may stem from atypicalities in sensory processing, particularly in the detection of environmental changes. Within the predictive coding framework, this intolerance may reflect altered generation and updating internal predictions in response to sensory input, leading to increased prediction errors. Mismatch negativity and the P3a component are event-related potentials (ERPs) indexing automatic auditory change detection and involuntary attention shift. While studied in autistic children and young adults, little is known about how these components evolve during aging, an important gap as 21 million autistic adults over 60 are expected by 2050. This study examined mismatch negativity and P3a responses in 43 autistic adults (aged 21-64) and 60 nonautistic adults (aged 20-69) using a passive auditory oddball paradigm with standard (1000 Hz) and deviant (1100 Hz; p = 0.15) tones. Electroencephalography recording revealed no significant differences between autistic and nonautistic individuals on mismatch negativity and P3a amplitude or latency. However, mismatch negativity amplitude decreased with age over frontal site, similarly across both groups. No age-related effects were found for mismatch negativity latency or P3a measures in either group. These findings suggest that, from adulthood onward, the neural mechanisms underlying automatic change detection and preattentional processes are similar in both autistic and nonautistic adults, and that their overall time course of aging appears comparable, supporting the parallel aging hypothesis. Nonetheless, future research should explore how these preserved neural responses relate to behavioral reactivity to change in autism.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"64 8","pages":"e70719"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149223566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Hippocampal Neural Network Dynamics in Rodents Using Virtual Reality: A Narrative Review on Systems, Spatial Coding, and Applications. 利用虚拟现实探索啮齿动物的海马体神经网络动力学：对系统、空间编码和应用的叙述回顾。

IF 2.5 4区医学

European Journal of Neuroscience Pub Date : 2026-10-01 DOI: 10.1111/ejn.70715

Neriman Ezgin, Fatma Kurul, Arif Engin Cetin, Dragan Hrnčić

引用次数: 0

Amyloid-Induced Network Resilience and Collapse in Alzheimer's Disease: Insights From Computational Modeling. 淀粉样蛋白诱导的阿尔茨海默病网络弹性和崩溃：来自计算模型的见解。

IF 2.5 4区医学

European Journal of Neuroscience Pub Date : 2026-10-01 DOI: 10.1111/ejn.70713

Ediline L F Nguessap, Damien Depannemaecker, Fernando F Ferreira

{"title":"Amyloid-Induced Network Resilience and Collapse in Alzheimer's Disease: Insights From Computational Modeling.","authors":"Ediline L F Nguessap, Damien Depannemaecker, Fernando F Ferreira","doi":"10.1111/ejn.70713","DOIUrl":"https://doi.org/10.1111/ejn.70713","url":null,"abstract":"Alzheimer's disease is marked by progressive synaptic loss and cognitive decline, with amyloid-beta accumulation playing a central pathological role. Although the molecular effects of amyloid-beta are well-characterized, the cascade from local synaptic dysfunction to large-scale network collapse remains poorly understood. We present a biophysically grounded computational model that integrates small-world network topology, Izhikevich neuron dynamics, short-term plasticity, and amyloid-beta-induced synaptic pruning to investigate how amyloid burden degrades functional brain connectivity over time. Crucially, we simulate the evolving network dynamics across disease stages, revealing how firing rate, synchrony, variability, and Fano factor evolve in response to progressive structural degradation. Our results demonstrate a two-phase deterioration: Initial compensatory dynamics followed by abrupt disintegration of coordinated activity. This temporal dissociation mirrors clinical observations and offers mechanistic insight into Alzheimer's disease progression. We further identify a critical accumulated amyloid dose beyond which network collapse becomes inevitable, preceded by early-warning indicators such as declining global efficiency and the spectral radius of the network connections. Network topology, synaptic time constants, and repair mechanisms strongly influence resilience, with small-world networks showing delayed collapse and greater functional compensation. Finite-size scaling reveals that larger networks experience earlier and sharper phase transitions. Ultimately, by establishing a mathematical link between microscopic synaptic degradation and macroscopic network failure, our findings suggest that if experimental proxies for the spectral radius can be identified, they would serve as highly sensitive early-warning indicators of impending network collapse. This theoretical framework offers new mechanistic targets for the early detection and therapeutic monitoring of neurodegenerative diseases.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"64 8","pages":"e70713"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149227564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Altered Timing of Self-Voice Processing in Parkinson's Disease. 帕金森氏症患者自我声音加工时间的改变

IF 2.5 4区医学

European Journal of Neuroscience Pub Date : 2026-10-01 DOI: 10.1111/ejn.70700

Francisco Contreras-Ruston, Antonio Criscuolo, Antonio Callén, David Cucurell, Jordi Navarra, Sonja A Kotz

{"title":"Altered Timing of Self-Voice Processing in Parkinson's Disease.","authors":"Francisco Contreras-Ruston, Antonio Criscuolo, Antonio Callén, David Cucurell, Jordi Navarra, Sonja A Kotz","doi":"10.1111/ejn.70700","DOIUrl":"10.1111/ejn.70700","url":null,"abstract":"Parkinson's disease (PD) affects voice and speech production, often resulting in reduced vocal intensity and monotonous speech. Recent studies suggest that these changes can be partially explained by altered sensory feedback processing in speech production: individuals with PD (IwPD) may fail to monitor and adapt sensory feedback when producing speech. We investigated PD voice production using a voice playback paradigm and focused on the sensory attenuation typically observed in event-related responses (ERPs) to the self-generated voice. When sensory feedback is intact, the P50, N100, and P200 responses to a self-generated voice are attenuated compared to an externally generated voice. Twenty-three IwPD and 23 matched healthy controls (HCs) completed the voice playback study with three conditions: self-generated voice (auditory-motor [AMC]), externally generated voice (auditory-only [AOC]), and motor-only. Linear mixed models assessed group differences in ERP morphology. Groups differed in the N100 latency response: IwPD showed a greater shift in latency between AMC and AOC than healthy controls. Regarding the P200, a significant group-by-condition interaction indicated that IwPD, unlike healthy controls, produced larger amplitudes for the self-generated than the passively listened to voice. Taken together, these findings suggest that the processing of one's own voice in IwPD is altered in terms of temporal precision rather than in the N100 suppression effect per se. This effect was accompanied by an enhanced P200 attentional response. These response patterns in IwPD are indicative of likely progressing difficulties in regulating one's own voice, characteristic of Parkinson's disease.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"64 7","pages":"e70700"},"PeriodicalIF":2.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13669414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149180209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rethinking the Oligodendrocyte Progenitor Cell: One Cell, Many Functions 少突胶质细胞祖细胞的再思考：一个细胞，多种功能

IF 2.5 4区医学

European Journal of Neuroscience Pub Date : 2026-09-29 DOI: 10.1111/ejn.70676

Alerie G. de la Fuente

{"title":"Rethinking the Oligodendrocyte Progenitor Cell: One Cell, Many Functions","authors":"Alerie G. de la Fuente","doi":"10.1111/ejn.70676","DOIUrl":"https://doi.org/10.1111/ejn.70676","url":null,"abstract":"Oligodendrocyte progenitor cells (OPCs) are resident progenitors and the largest cycling nonneuronal population of the central nervous system (CNS). For decades, OPCs were defined by a single output—the myelinating oligodendrocyte. However, a growing body of evidence has since revealed a cell whose functions reach well beyond myelin, raising the question of whether the OPC should be regarded as a glial cell type in its own right. In this review I examine a broader repertoire of OPC functions and their relevance to CNS health and disease, alongside myelination, remyelination and myelin maintenance. Beyond forming myelinating oligodendrocytes, OPCs tune myelination to neuronal activity, regulate neural circuits directly, influence the vasculature and blood–brain barrier and act as immune sensors and effectors. These emerging myelin-independent functions establish OPCs as active participants in CNS physiology and pathology rather than a cell defined solely by the oligodendrocytes it produces. Finally, I consider two challenges shared across all these functions and that have, until now, been studied almost exclusively in relation to myelination: OPC heterogeneity and ageing. Whether these noncanonical functions are performed by all OPCs or by distinct subsets and inducible states and how each function is shaped across the lifespan and in pathological contexts, remains unresolved. I propose that addressing these questions is essential to understanding the relevance of these different OPC functions in health and disease.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"64 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70676","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149072646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial Attention and Session Day Jointly Modulate Human Visual Cortical Plasticity 空间注意和会话日共同调节人类视觉皮质可塑性

IF 2.5 4区医学

European Journal of Neuroscience Pub Date : 2026-09-29 DOI: 10.1111/ejn.70695

Patricia Naomi Limon, Anthony Norcia, Ryan Thomas Ash

{"title":"Spatial Attention and Session Day Jointly Modulate Human Visual Cortical Plasticity","authors":"Patricia Naomi Limon, Anthony Norcia, Ryan Thomas Ash","doi":"10.1111/ejn.70695","DOIUrl":"https://doi.org/10.1111/ejn.70695","url":null,"abstract":"<div>\u0000 \u0000 Visual-evoked potential plasticity (VEPP) is a noninvasive form of cortical neuroplasticity elicited by repeated presentation of high-contrast visual stimuli. In rodent models, stimulus-specific response potentiation (SSRP) effects accumulate across days; however, it remains unclear whether repeated exposure across days influences the magnitude or specificity of potentiation in humans. In addition, visual cortical plasticity may not be determined by experience alone: voluntary attentional deployment selects which inputs are prioritized, and may thereby determine how much a given amount of sensory experience alters cortical excitability. Here, we examined whether covert spatial attention and repeated exposure across days modulate VEPP strength using high-density electroencephalography (EEG) in neurotypical adults. An established VEP modulation paradigm was modified to use steady-state visual evoked potential (SSVEP) stimuli, which we refer to as steady-state visual response potentiation (SSVRP). Pre- and post-induction amplitudes were measured using frequency-tagged (6 and 7.5 Hz) bilateral hemifield contrast-sweep checkerboard steady-state visual evoked potentials (SSVEPs). A 10-min, high-contrast, 2 Hz sign-reversing induction stimulus was presented exclusively to the left hemifield, with the right serving as control. Across two experimental sessions, participants attended either toward or away from the potentiated hemifield during induction. Notably, attention enhanced SSVRP in the first session day but not the second session day, reflecting a significant interaction between attention and session day. Potentiation was significantly greater on the second session day, independent of attention condition. Of note, potentiation occurred in both hemifields despite the potentiating stimulus only being presented in the left hemifield. Our results tentatively suggest that spatial attention and experience jointly modulate human visual cortical plasticity.\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"64 7","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149072647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Partial Learning in Human Sound Localization With Asymmetric Ears 不对称耳朵对人类声音定位的部分学习

IF 2.5 4区医学

European Journal of Neuroscience Pub Date : 2026-09-25 DOI: 10.1111/ejn.70685

Peter Bremen, Robert F. van der Willigen, A. John van Opstal, Marc M. van Wanrooij

{"title":"Partial Learning in Human Sound Localization With Asymmetric Ears","authors":"Peter Bremen, Robert F. van der Willigen, A. John van Opstal, Marc M. van Wanrooij","doi":"10.1111/ejn.70685","DOIUrl":"https://doi.org/10.1111/ejn.70685","url":null,"abstract":"The brain computes sound location from auditory spatial cues. Humans and barn owls both localize sounds accurately, yet they rely on fundamentally different cue configurations shaped by their ear anatomy and neural circuitry. In humans, symmetrical ears provide interaural time and level differences (ITD and ILD) for horizontal localization, while vertical localization depends primarily on high-frequency, monaural spectral cues generated by the pinnae. Barn owls, by contrast, possess asymmetrical ears and use binaural cues for both azimuth and elevation. Because auditory pathways are tuned to species-specific cue statistics, it remains unclear whether humans can adapt when binaural level cues are also made informative about elevation. We tested this by fitting human listeners with asymmetric ear molds that disrupted normal spectral cues, introduced elevation-dependent ILDs, and left ITDs unaffected. Participants wore the molds during daily life and were tested with broadband, high-pass, and low-pass noise bursts. Acute mold exposure severely degraded elevation localization, whereas horizontal localization remained largely unaffected. With prolonged exposure, elevation localization improved, but adaptation was limited, variable across listeners, and fluctuated across sessions. Improvement was strongest for broadband sounds. Because broadband and high-pass sounds both contained high-frequency information, this broadband advantage cannot be explained by access to additional spectral cues alone. Instead, it suggests that low-frequency ITDs helped listeners exploit the altered binaural cue structure, including the elevation-dependent ILDs introduced by the molds. These findings show that humans can partially adapt to asymmetric outer-ear acoustics when complementary spatial cues help resolve ambiguity in the altered cue structure.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"64 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70685","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149048500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptional Alteration in TRKβ-SHC Isoform as a Neuroprotective Factor for Post-Stroke Memory Outcomes TRKβ-SHC亚型转录改变作为脑卒中后记忆结果的神经保护因子。

IF 2.5 4区医学

European Journal of Neuroscience Pub Date : 2026-09-20 DOI: 10.1111/ejn.70684

Dipanwita Sadhukhan, Raktim Chowdhury, Saranya Roy, Arunima Roy, Shreyosi Maitra, Kartik Chandra Ghosh, Joydeep Mukherjee, Tapas Kumar Banerjee, Subhra Prakash Hui, Saikat Chakrabarti, Arindam Biswas

{"title":"Transcriptional Alteration in TRKβ-SHC Isoform as a Neuroprotective Factor for Post-Stroke Memory Outcomes","authors":"Dipanwita Sadhukhan, Raktim Chowdhury, Saranya Roy, Arunima Roy, Shreyosi Maitra, Kartik Chandra Ghosh, Joydeep Mukherjee, Tapas Kumar Banerjee, Subhra Prakash Hui, Saikat Chakrabarti, Arindam Biswas","doi":"10.1111/ejn.70684","DOIUrl":"10.1111/ejn.70684","url":null,"abstract":"<div>\u0000 \u0000 Post-stroke cognitive impairment (PSCI) affects nearly 30% of stroke survivors and substantially limits functional recovery. Brain-derived neurotrophic factor (BDNF)–tropomyosin receptor kinase-β (Trkβ) signalling plays an important role in synaptic plasticity and cognitive function; however, the contribution of individual NTRK2/Trkβ isoforms to PSCI remains poorly understood. This study investigated (a) isoform-specific NTRK2 mRNA expression, (b) genetic association of the isoform-specific variant rs6559833 with post-stroke cognitive outcomes and (c) DNA methylation patterns potentially regulating NTRK2 expression using blood as primary biosource. Isoform-specific expression was analysed in 50 subjects, rs6559833 was genotyped in 280 ischemic stroke patients, and DNA methylation was assessed in 10 samples using whole-genome bisulfite sequencing. The TRKβ-FL expression was significantly reduced in stroke patients compared with healthy controls, whereas TRKβ-SHC expression was higher in PSCN individuals than in PSCI patients. The latter showed positive correlation with MEK2 expression and memory performance. The ‘TT’ genotype of the rs6559833 variant showed marginal associations with post-stroke memory status and overall BMSE scores (p = 0.0442 and 0.0488, respectively). Furthermore, hypermethylation was observed within the NTRK2 gene body and in genes encoding its splicing regulators, whereas no evident difference in promoter methylation was observed. Collectively, these findings suggest that Trkβ-SHC expression may be associated with preserved cognitive function after stroke and indicate a potential relationship between isoform-specific NTRK2 expression, genetic regulation and cognitive outcomes in PSCI.\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"64 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Baseline Dynamics and Sleep Loss–Driven Changes of Electrocorticographic Aperiodic Properties Are Altered in Mice Lacking Neuroligin-2 在缺乏神经胶质素-2的小鼠中，基线动态和睡眠缺失驱动的皮质电图非周期特性改变。

IF 2.5 4区医学

European Journal of Neuroscience Pub Date : 2026-09-20 DOI: 10.1111/ejn.70665

Tanya Leduc, Janine El Helou, Erika Bélanger-Nelson, Clément Bourguignon, Jean-Marc Lina, Valérie Mongrain

{"title":"Baseline Dynamics and Sleep Loss–Driven Changes of Electrocorticographic Aperiodic Properties Are Altered in Mice Lacking Neuroligin-2","authors":"Tanya Leduc, Janine El Helou, Erika Bélanger-Nelson, Clément Bourguignon, Jean-Marc Lina, Valérie Mongrain","doi":"10.1111/ejn.70665","DOIUrl":"10.1111/ejn.70665","url":null,"abstract":"Spectral power decay (1/fβ) of cortical activity has long been considered of low relevance to the understanding of brain function (e.g., associated with background noise of neuronal activity). However, growing literature suggests that it can reflect optimized spatiotemporal organization of neuronal activity across the cortex serving both cognition and behavior. Thus, clarifying the mechanisms underlying the regulation of this network property could have numerous impacts for the neuroscience field as well as for patients suffering from various neurological disorders with cognitive deficits linked to alterations in brain power decay properties. Using a constitutive knockout mouse and a multifractal wavelet-leaders formalism, we here investigated the involvement of the synaptic adhesion molecule Neuroligin-2, which shapes synaptic inhibition and associates with neurodevelopmental diseases, in modulating spectral power decay properties of the electrocorticographic signal (i.e., the most prominent Hurst exponent “Hm” and its local “Dispersion”). Knockout mice showed increased Hm values across all wake and sleep states together with amplified daily dynamics during wake and paradoxical sleep, and increased Dispersion specifically for slow-wave sleep in comparison with wild-type littermates. Following a 6-h sleep deprivation, Hm daily variations were more altered in knockout mice than controls for wake and paradoxical sleep, but less affected for slow-wave sleep. Importantly, mutant mice display hypersynchronized epileptic-like electrocorticographic events, which were characterized by further increases in Hm and Dispersion. These findings provide support for the involvement of Neuroligin-2 in shaping 1/fβ cortical activity properties and bring perspectives, notably, for neurodevelopmental conditions.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"64 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13590249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Optic Flow on Electrocortical Dynamics During Walking and Stepping Over Virtual Obstacles 行走和跨越虚拟障碍物时光流对脑电动力学的影响。

IF 2.5 4区医学

European Journal of Neuroscience Pub Date : 2026-09-20 DOI: 10.1111/ejn.70694

Marco A. Bühler, Joyce Fung, Anouk Lamontagne

{"title":"Effects of Optic Flow on Electrocortical Dynamics During Walking and Stepping Over Virtual Obstacles","authors":"Marco A. Bühler, Joyce Fung, Anouk Lamontagne","doi":"10.1111/ejn.70694","DOIUrl":"10.1111/ejn.70694","url":null,"abstract":"Successful obstacle avoidance relies on complex visuomotor processes. Although optic flow provides critical information about self-motion and object motion, the neural mechanisms underlying its role during obstacle avoidance remain largely unexplored. To address this gap, we developed a treadmill-based virtual reality paradigm to investigate cortical dynamics during obstacle avoidance performed with and without optic flow. Accordingly, 24 healthy adults walked on a treadmill and stepped over virtual obstacles in two environments: one with optic flow (textured walls/ceiling) and one without. Electroencephalography data were recorded, decomposed with independent component analysis, and clustered within the sensorimotor, parietal, and occipital regions. Time-frequency power was compared across conditions in the theta, alpha, and beta bands. Results revealed transient theta synchronizations shortly after obstacle presentation and before obstacle clearance were observed in all regions and conditions, together with sustained alpha/beta desynchronizations throughout the planning phase. Optic flow enhanced pre-obstacle alpha desynchronizations and uniquely induced sustained occipital theta synchronization in the same period. These modulations in electrocortical activity in the optic flow condition before obstacle presentation likely reflect responses associated with self-motion, whereas its persistence after obstacle presentation suggests a shared contribution of self- and object-motion processing. Sensorimotor alpha power decreased after obstacle presentation, indicating increased engagement in motor planning. Together, these findings demonstrate that optic flow shapes electrocortical dynamics during obstacle avoidance by eliciting distinct neural signatures associated with visual motion processing and motor planning.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"64 6","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13591062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0