European Journal of Neuroscience最新文献_第3页

The Possible Role of Metformin and Fibroblast Growth Factor-21 in Multiple Sclerosis Neuropathology: Birds of a Feather Flock Together

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-04-02 DOI: 10.1111/ejn.70067

Ahmad A. Abulaban, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Eman A. Ahmed, Mubarak Alruwaili, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batiha

{"title":"The Possible Role of Metformin and Fibroblast Growth Factor-21 in Multiple Sclerosis Neuropathology: Birds of a Feather Flock Together","authors":"Ahmad A. Abulaban, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Eman A. Ahmed, Mubarak Alruwaili, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batiha","doi":"10.1111/ejn.70067","DOIUrl":"https://doi.org/10.1111/ejn.70067","url":null,"abstract":"Multiple sclerosis (MS) is a progressive demyelinating disease of the CNS, characterized by inflammation, the formation of CNS plaques, and damage to the neuronal myelin sheath (Graphical abstract). Fibroblast growth factor 21 (FGF21) is involved in various metabolic disorders and neurodegenerative diseases. FGF21 and its co-receptor β-Kloth are essential in the remyelination process of MS. Metformin, an insulin-sensitizing drug that is the first-line treatment for type 2 diabetes mellitus (T2DM), may have a potential neuroprotective impact by up-regulating the production of FGF21, which may prevent the onset of neurodegenerative diseases including MS. The purpose of this review is to clarify how metformin affects MS neuropathology mechanistically via modifying FGF21. Metformin increases the expression of FGF21. Metformin also increases the expression of β-Klotho, modulates oxidative stress, reduces glutamate-induced excitotoxicity, and regulates platelet function and coagulation cascades. In conclusion, metformin can enhance the functional activity of FGF21 in counteracting the development and progression of MS. Preclinical and clinical studies are warranted in this regard.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70067","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quadriceps Strength and Temporal Preparation in Elderly Adults: The Mediating Role of Beta Oscillation

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-04-01 DOI: 10.1111/ejn.70101

Ming-Cho Ho, Hao-Lun Fu, Shih-Chun Kao, David Moreau, Wei-Kuang Liang, Hsin-Yu Kuo, Chun-Hao Wang

{"title":"Quadriceps Strength and Temporal Preparation in Elderly Adults: The Mediating Role of Beta Oscillation","authors":"Ming-Cho Ho, Hao-Lun Fu, Shih-Chun Kao, David Moreau, Wei-Kuang Liang, Hsin-Yu Kuo, Chun-Hao Wang","doi":"10.1111/ejn.70101","DOIUrl":"https://doi.org/10.1111/ejn.70101","url":null,"abstract":"This study investigated the relationship between lower limb muscle strength and temporal preparation in older adults using an electroencephalogram to assess neural oscillations during cognitive processes. Forty older adults were divided into higher (HSG, 70.40 ± 5.15 years) and lower muscle strength (LSG, 71.43 ± 4.86 years) groups based on quadriceps strength estimated via a manual muscle test. Functional mobility was assessed using the Timed Up and Go (TUG) test, while temporal preparation was evaluated using a choice response time (RT) task with randomly varying foreperiods (FPs) that required lower limb motor responses. The HSG outperformed the LSG on both the TUG test (HSG: 6.07 ± 1.14 vs. LSG: 6.79 ± 0.88, p = 0.031) and the cognitive task (HSG: 462.97 ± 51.06 ms vs. LSG: 525.86 ± 73.69 ms, p = 0.002), despite no clear FP effect in either group. Additionally, the HSG demonstrated a more pronounced modulation of oscillatory beta power during the late phase of longer FP trials (qs < 0.05, FDR corrected), whereas no significant modulation was observed during shorter FP trials. Crucially, mediation analysis indicated that beta power significantly mediated the relationship between lower limb strength and RT in longer FP trials [b = −24.21; 95% CI = (−53.51, −0.24)]. In summary, these findings suggest that lower limb strength may influence the development of temporal preparation during longer preparatory periods by modulating beta power, potentially serving as a compensatory mechanism to mitigate age-related declines in cognitive processing speed and preserve functional mobility.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70101","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Shrinking the Skin: Motion Results in Compressive Mislocalization of Stimuli Applied 10 s Post-Motion

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-04-01 DOI: 10.1111/ejn.70076

Tatjana Seizova-Cajic, Jack Brooks, Janet Taylor

{"title":"Shrinking the Skin: Motion Results in Compressive Mislocalization of Stimuli Applied 10 s Post-Motion","authors":"Tatjana Seizova-Cajic, Jack Brooks, Janet Taylor","doi":"10.1111/ejn.70076","DOIUrl":"https://doi.org/10.1111/ejn.70076","url":null,"abstract":"Localizing touch on the skin requires integration of multiple spatial signals, including reference landmarks and motion cues. It is well known that motion patterns can bias the perceived endpoint of motion. However, it is unknown whether static touch presented post-motion is also distorted. To investigate this, we presented space-changing motion patterns and tested position perception 1 s and 10 s post-motion. We used a brush moving along the forearm at 15 cm s−1, brushing 4.5 cm skin patches near the elbow and near the wrist, skipping a 10-cm long metal-shielded patch in the middle (‘numb spot’). It accelerated to 100 cm s−1 across the shielded gap in an attempt to create an illusion of continuous motion between the separate brushed areas. After several such deceptive motions, 12 participants indicated the locations touched by a von Frey filament near the elbow and wrist, all within the previously brushed areas. Localization responses shifted 4–10 mm towards the numb spot in the skipped-patch condition compared with controls with either continuous brushing across the full forearm, or brushing the same patches without acceleration. This spatial distortion was equally strong 1 s and 10 s after motion offset with only isolated location-specific differences between delays. In addition, participants' sketches indicated a reduction in perceived gap size. We propose that participants used the brushed fields as reference frame for localisation, with the high-velocity motion compressing the perceived space between them. This means that motion-defined boundaries can serve as spatial landmarks for static touch.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70076","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Motor Cortex Activation Patterns in Both Hemispheres Induced by Motor Imagery in Patients With Right- and Left-Sided Cerebral Infarction: An fNIRS Study

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-04-01 DOI: 10.1111/ejn.70079

Jialing Wang, Xinyu Jia, Jianfei Song, Zhengyuan Qin, Manting Cao, Jianer Chen

{"title":"Motor Cortex Activation Patterns in Both Hemispheres Induced by Motor Imagery in Patients With Right- and Left-Sided Cerebral Infarction: An fNIRS Study","authors":"Jialing Wang, Xinyu Jia, Jianfei Song, Zhengyuan Qin, Manting Cao, Jianer Chen","doi":"10.1111/ejn.70079","DOIUrl":"https://doi.org/10.1111/ejn.70079","url":null,"abstract":"This study aimed to explore the neuroimaging basis of motor imagery (MI) in stroke rehabilitation, particularly focusing on the brain activation patterns during MI tasks. Additionally, this study may provide insights into clinical rehabilitation strategies. A total of 40 right-handed stroke patients from Zhejiang Rehabilitation Medical Center were assigned to either the right-sided or left-sided cerebral infarction group. They were right-handed and recruited from Zhejiang Rehabilitation Medical Center. A portable near-infrared brain function imaging system was used to detect changes in oxyhemoglobin concentration in the bilateral sensorimotor cortex, premotor cortex, and supplementary motor area during the MI task. Activated channels and intensity changes in brain regions under the MI state were observed and analyzed. In patients with right-sided cerebral infarction, brain activation was left-lateralized during both left- and right-limb MI. Patients with left-sided cerebral infarction exhibited left lateralization during right-limb MI and right lateralization during left-limb MI. Functional near-infrared spectroscopy was utilized to investigate the activation of motor-related brain regions during MI after stroke. These regions of interest were associated with hand motor tasks and were successfully activated during the MI task. Following infarction, the activation of the MI cortex was asymmetric. When imagining movements on the dominant-hand side, MI becomes more vivid and activates bilateral motor cortex areas.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70079","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Focused Ultrasound Neuromodulation to Peripheral Nerve System

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-04-01 DOI: 10.1111/ejn.70062

Yufeng Zhou

引用次数: 0

Layer-Specific Connectivity and Functional Interference of Chrna2+ Layer 5 Martinotti Cells in the Primary Motor Cortex

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-04-01 DOI: 10.1111/ejn.70086

Anna Velica, Katharina Henriksson, Thawann Malfatti, Barbara Ciralli, Ingrid Nogueira, Evridiki Asimakidou, Klas Kullander

{"title":"Layer-Specific Connectivity and Functional Interference of Chrna2+ Layer 5 Martinotti Cells in the Primary Motor Cortex","authors":"Anna Velica, Katharina Henriksson, Thawann Malfatti, Barbara Ciralli, Ingrid Nogueira, Evridiki Asimakidou, Klas Kullander","doi":"10.1111/ejn.70086","DOIUrl":"https://doi.org/10.1111/ejn.70086","url":null,"abstract":"The cortical somatostatin interneuron population includes several diverse cell types, among them the Martinotti cells. Layer-specific differences in connectivity and function between different subtypes of Martinotti cells are becoming apparent, which require contemporary studies to investigate cortical interneurons in a layer and subtype-specific manner. In this study, we investigate the connectivity of a subtype of Chrna2+ layer 5 Martinotti cells in the primary motor cortex, using a monosynaptic retrograde rabies viral tracer. We found direct input from pyramidal cells and local parvalbumin interneurons. In addition, we found long-range direct inputs from the motor thalamus, substantia innominata of the basal forebrain, and globus pallidus. Based on the observed input pattern, we tested and found an increased number of falls in the hanging wire test upon temporary overexcitation of Chrna2+ layer 5 Martinotti cells, suggesting that Chrna2+ Martinotti cells in the motor cortex can interfere with sensorimotor integration. In summary, our study provides novel insights into the connectivity and functional role of Mα2 cells in the M1 forelimb area, highlighting their unique integration of local and long-range inputs critical for sensorimotor processing, which lay the groundwork for further exploration of their role in cortical plasticity and motor learning.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70086","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction and Validation of the Modified Parietal Atrophy Index by Magnetic Resonance Imaging in Patients With Alzheimer's Disease in a Memory Clinic

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-31 DOI: 10.1111/ejn.70095

Alberto José Mimenza-Alvarado, Daniel Alberto Herrera-Martínez, Johnatan Rubalcava-Ortega, Michelle Yanieska González-Putoy, Juan de Dios Rodríguez-Callejas, Sara Gloria Aguilar-Navarro

{"title":"Construction and Validation of the Modified Parietal Atrophy Index by Magnetic Resonance Imaging in Patients With Alzheimer's Disease in a Memory Clinic","authors":"Alberto José Mimenza-Alvarado, Daniel Alberto Herrera-Martínez, Johnatan Rubalcava-Ortega, Michelle Yanieska González-Putoy, Juan de Dios Rodríguez-Callejas, Sara Gloria Aguilar-Navarro","doi":"10.1111/ejn.70095","DOIUrl":"https://doi.org/10.1111/ejn.70095","url":null,"abstract":"<div>\u0000 \u0000 Magnetic resonance imaging (MRI) is pivotal to the evaluation of cerebral atrophy in Alzheimer's disease (AD). Although there are several scoring systems to identify atrophy in areas of interest, the possibility of having a simple and practical scale focused on evaluating parietal atrophy by MRI in a single axial slice in T2-Flair sequencing would be highly advantageous. We develop and validate the Mimenza–Aguilar–Herrera (MAH) visual scale to determine the degree of modified parietal atrophy by analyzing the posterior cingulate gyrus in an MRI axial slice in T2 weighted sequencing in individuals with early AD. Patients with AD, mild cognitive impairment, and other dementias were included. Interrater and intrarater concordance was analyzed with Cohen's kappa. ROC analysis was used to determine sensitivity/specificity. The relationship between medial parietal atrophy (MPA) and the MMSE and MoCA scores, age, educational level, and sex was determined by linear regression. Interrater concordance in the MPA-MAH was moderate, 0.83 (p = 0.001). The area under the curve in the mild AD group was 0.74, with a sensitivity of 71.67% and a specificity of 76.19% (p < 0.001). An association was detected between a MPA score > 1 [OR 5.1 (95% CI: 2–12.9, p < 0.001)], MMSE < 24 pts, [OR 4.5 (95% CI: 1.2–17.6, p = 0.026)], and MoCA < 24 pts, after adjusting for age and sex. The MAH scale proved useful in diagnosing early AD, with comparable performance to validated scales such as Koedam's and Scheltens'. This instrument could allow a quick and easy evaluation.\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transient Reduction of Frontal Midline Theta Activity During Attentional Shifts in Healthy Young Adults

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-31 DOI: 10.1111/ejn.70093

Tomohiro Ohgomori, Keigo Shiraiwa, Yasuo Naito, Ryouhei Ishii

{"title":"Transient Reduction of Frontal Midline Theta Activity During Attentional Shifts in Healthy Young Adults","authors":"Tomohiro Ohgomori, Keigo Shiraiwa, Yasuo Naito, Ryouhei Ishii","doi":"10.1111/ejn.70093","DOIUrl":"https://doi.org/10.1111/ejn.70093","url":null,"abstract":"<div>\u0000 \u0000 The prefrontal cortex, well-developed in humans, plays a crucial role in various behavioural outcomes. Neuronal resources are limited, however, and must be appropriately allocated. A specific type of theta activity, known as frontal midline theta (Fmθ), is intermittently observed in the frontal midline region during intense concentration to tasks. Meanwhile, the power of Fmθ activity is stronger in individuals with excessive concentration than in those who are not engaged in such state. Fmθ activity in healthy young adults is therefore speculated to be reduced when shifting attention from one target to another. However, the neuronal mechanisms of Fmθ reduction are largely unknown. In this study, 20 healthy young male adults performed 2-back cognitive tasks including two pieces of information (colour and position). Participants initially pay attention to one of them at the start of the task, and then to shift attention to the other when the screen's background colour was changed. Transient reduction of theta activity was observed with the attentional shift, and high current source density was observed in the medial prefrontal and the anterior cingulate regions. Reduction of alpha activity in the left inferior parietal lobe was simultaneously observed during the attentional shift. Moreover, there was a significant positive correlation between the reduction of Fmθ and alpha activity in the left parietal area. The reduction of Fmθ activity and the change in activity of the inferior parietal lobe may play an essential role in disengaging from intense concentration and the appropriate attentional shift.\u0000 Trial Registration: UMIN000051023.\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards a Conceptual Framework to Better Understand the Advantages and Limitations of Model Organisms

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-31 DOI: 10.1111/ejn.70071

Markus Kunze, Federica Malfatti

{"title":"Towards a Conceptual Framework to Better Understand the Advantages and Limitations of Model Organisms","authors":"Markus Kunze, Federica Malfatti","doi":"10.1111/ejn.70071","DOIUrl":"https://doi.org/10.1111/ejn.70071","url":null,"abstract":"Model organisms (MO) are widely used in neuroscience to study brain processes, behavior, and the biological foundation of human diseases. However, the use of MO has also been criticized for low reliability and insufficient success rate in the development of therapeutic approaches, because the success of MO use also led to overoptimistic and simplistic applications, which sometimes resulted in wrong conclusions. Here, we develop a conceptual framework of MO to support scientists in their practical work and to foster discussions about their power and limitations. For this purpose, we take advantage of concepts developed in the philosophy of science and adjust them for practical application by neuroscientists. We suggest that MO can be best understood as tools that are used to gain information about a group of species or a phenomenon in a species of interest. These learning processes are made possible by some properties of MO, which facilitate the process of acquisition of understanding or provide practical advantages, and the possibility to transfer information between species. However, residual uncertainty in the reliability of information transfer remains, and incorrect generalizations can be side-effects of epistemic benefits, which we consider as representational and epistemic risks. This suggests that to use MO most effectively, scientists should analyze the similarity relation between the involved species, weigh advantages and risks of certain epistemic benefits, and invest in carefully designed validation experiments. Altogether, our analysis illustrates how scientists can benefit from philosophical concepts for their research practice.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70071","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Interplay Between Experimental Heat Pain and Noninvasive Stimulation of the Medial Prefrontal Cortex on Reinforcement Learning With Manipulated Outcome Contingencies

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-31 DOI: 10.1111/ejn.70089

Samy Babiker, Federica Luzzi, Matthias Mittner, Gábor Csifcsák

{"title":"The Interplay Between Experimental Heat Pain and Noninvasive Stimulation of the Medial Prefrontal Cortex on Reinforcement Learning With Manipulated Outcome Contingencies","authors":"Samy Babiker, Federica Luzzi, Matthias Mittner, Gábor Csifcsák","doi":"10.1111/ejn.70089","DOIUrl":"https://doi.org/10.1111/ejn.70089","url":null,"abstract":"<div>\u0000 \u0000 Pain negatively affects several cognitive abilities, but knowledge about its effect on reinforcement learning (RL) is limited. During RL, instrumental choices can be influenced by heuristic tendencies to approach rewards or inhibit actions when facing potentially aversive events, introducing “Pavlovian bias” in behavior. Recent studies suggest that compromised outcome controllability enhances Pavlovian bias, a phenomenon that may be linked to suboptimal decision-making in learned helplessness (LH). Since LH is common in chronic pain syndromes, this study sought to establish a link between experimental heat pain (EHP), disrupted reward/loss contingencies, and RL performance in healthy adults. In addition, we investigated if intermittent theta burst stimulation (iTBS) above the medial prefrontal/dorsal anterior cingulate cortex (mPFC/dACC) alleviates the deleterious effects of EHP on choice behavior. In a preregistered, 2 × 2 between-group, double-blind study (N = 100), healthy adult participants underwent three blocks of an orthogonalized Go/NoGo task with two interleaved bouts of active or sham iTBS, and either EHP or warm skin stimulation combined with manipulated response–outcome contingency during the task. Although EHP did not impact response accuracy, it invigorated actions for rewards, reflecting enhanced Pavlovian bias. Whereas two bouts of iTBS attenuated Pavlovian tendencies, this effect was counteracted by EHP, indicating antagonistic effects of pain and iTBS-modulated mPFC activity on Pavlovian–instrumental interactions. Surprisingly, EHP and iTBS exerted largely similar effects on other latent parameters of RL (go-bias, learning rate, and exploration) in a manner that resembled LH. These findings shed light on the role of experimental pain and mPFC/dACC activity in LH-like choice behavior.\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0