European Journal of Neuroscience最新文献

{"title":"The Effect of Cue Frequency, Modality and Rhythmicity on Finger Tapping Behaviour and Movement-Related Cortical Activity","authors":"Janne J. A. Heijs,&nbsp;Silvana Huertas-Penen,&nbsp;Marc M. van Wanrooij,&nbsp;Bettina C. Schwab,&nbsp;Richard J. A. van Wezel,&nbsp;Tjitske Heida","doi":"10.1111/ejn.70112","DOIUrl":"https://doi.org/10.1111/ejn.70112","url":null,"abstract":"<p>Sensorimotor synchronization (SMS) involves the coordination of movements with rhythmic sensory cues. While cue characteristics influence SMS behaviour and neural pathways, their impact on cortical activity beyond motor areas is less understood. This exploratory EEG study examined how various cue characteristics, including cue frequency, modality and rhythmicity, influence behaviour and movement-related cortical activity in (non-)motor areas during SMS. Seventeen healthy participants performed finger tapping with cues varying in frequency (slow: 1 Hz, fast: 3.2 Hz), modality (visual, auditory) and rhythmicity (isorhythmic, polyrhythmic). SMS behaviour and movement-related beta power were evaluated. Key findings include the following: (1) Increasing cue frequency, and therefore movement speed, reduced tap accuracy, especially with visual cues. Slow cues induced strong beta suppression followed by beta rebound after the tap in the contralateral sensorimotor cortex, while fast cues induced a weaker but sustained beta suppression. (2) Auditory cues enabled more accurate tap behaviour and induced stronger beta suppression in the contralateral premotor cortex compared to visual cues. (3) Polyrhythmic auditory cues delayed taps compared to isorhythmic cues, although tap accuracy was similar. Isorhythmic cues enhanced frontoparietal beta power, whereas polyrhythmic cues showed widespread right-hemispheric beta suppression. Findings suggest discrete and continuous movement processing with slow and fast cues, respectively. Auditory cues offer more sensory guidance, especially at higher frequencies. Endogenous, top-down control with isorhythmic cues may switch towards stimulus-driven, bottom-up control with auditory polyrhythmic cues. Overall, our findings highlight how cue characteristics shape motor behaviour and neural processes, suggesting distinct movement control strategies depending on frequency, modality and rhythmicity.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70112","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain Stimulation May Be a Subliminal Technique Under the European Union's Artificial Intelligence Act","authors":"Jan Christoph Bublitz,&nbsp;Philipp Kellmeyer,&nbsp;Fruzsina Molnár-Gábor","doi":"10.1111/ejn.70115","DOIUrl":"https://doi.org/10.1111/ejn.70115","url":null,"abstract":"","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143849232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Neural Oscillatory Basis of Perspective-Taking in Autistic and Non-Autistic Adolescents Using Magnetoencephalography","authors":"Robert A. Seymour,&nbsp;Gina Rippon,&nbsp;Gerard Gooding-Williams,&nbsp;Hongfang Wang,&nbsp;Klaus Kessler","doi":"10.1111/ejn.70109","DOIUrl":"https://doi.org/10.1111/ejn.70109","url":null,"abstract":"<p>Taking another's perspective is a high-level mental skill underlying many aspects of social cognition. Perspective-taking is usually an embodied egocentric process whereby people mentally rotate themselves away from their physical location into the other's orientation. This is accompanied by increased theta-band (3–7 Hz) brain oscillations within a widespread fronto-parietal cortical network including the temporoparietal junction. Individuals with autism spectrum conditions (ASC) have been reported to experience challenges with high-level perspective-taking, particularly when adopting embodied strategies. To investigate the potential neurophysiological basis of these autism-related individual differences, we used magnetoencephalography in combination with a well-replicated perspective-taking paradigm in a group of 18 autistic and 17 age-matched non-autistic adolescents. Findings revealed that increasing the angle between self and other perspective resulted in prolonged reaction times for the autistic group during perspective-taking. This was accompanied by reduced theta power across a wide network of regions typically active during social cognitive tasks. On the other hand, the autistic group showed greater alpha power decreases in visual cortex compared with the non-autistic group across all perspective-taking conditions. These divergent theta and alpha power effects, coupled with steeper response time slopes, suggest that autistic individuals may rely more on alternative cognitive strategies, such as mental object rotation, rather than an egocentric embodied approach. Finally, no group differences were found when participants were asked to track, rather than take, another's viewpoint, suggesting that autism-related individual differences are specific to high-level perspective-taking.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70109","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143835804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maintaining Brain Health: The Impact of Physical Activity and Fitness on the Aging Brain—A UK Biobank Study","authors":"Hanna Hoogen,&nbsp;Bruno Hebling Vieira,&nbsp;Nicolas Langer","doi":"10.1111/ejn.70085","DOIUrl":"https://doi.org/10.1111/ejn.70085","url":null,"abstract":"<div>\u0000 \u0000 <p>The growing prevalence of physical and neurological disorders linked to aging poses significant challenges for society. Many of these disorders are closely linked to changes in brain structure and function, highlighting the importance of identifying protective factors that can preserve brain structure in later life and mitigate age-related decline. Physical activity (PA) is consistently linked to physical health and was found to mitigate age-related disorders. However, its effects on markers of brain aging remain inconclusive, partly due to reliance on underpowered studies and self-reported data. We investigated the effects of accelerometer-measured PA and physical fitness on BrainAGE, a machine-learning-derived marker of brain aging, in a large UK Biobank cohort. Using cortical and subcortical neuroimaging-derived features, a BrainAGE model was trained on 21,442 participants (mean absolute error: 3.75 years) and applied to predict BrainAGE for an independent sample of 10,874 participants. Accelerometer-measured moderate-intensity PA, but not self-reported PA, was associated with decelerated brain aging, indicated by a negative BrainAGE. Further, higher hand grip strength, along with lower body mass index (BMI), diastolic blood pressure (DBP), and resting heart rate, was linked to decelerated aging. These fitness measures impacted BrainAGE independently of PA. Additionally, fitness partially accounted for the relationship between PA and BrainAGE. Specifically, BMI, DBP, and resting heart rate showed a significant mediating effect, while grip strength did not. These findings highlight the interplay between PA and fitness in maintaining brain health and provide valuable insights for neuroscience and preventive health measures.</p>\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143835800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “The History of Danish Neuroscience”","authors":"","doi":"10.1111/ejn.70113","DOIUrl":"https://doi.org/10.1111/ejn.70113","url":null,"abstract":"<p>\u0000 <span>Paulson, O.B.</span>, <span>Schousboe, A.</span> and <span>Hultborn, H.</span> (<span>2023</span>), <span>The History of Danish Neuroscience</span>. <i>European Journal of Neuroscience</i>, <span>58</span>: <span>2893</span>–<span>2960</span>. https://doi.org/10.1111/ejn.16062.\u0000 </p><p>In the paper by Paulson et al. (2023), there was an error in the legend for Figure 1.</p><p>The correct legend should be</p><p>FIGURE 1. Nicolaus Steno. <i>Source:</i> Painted by C. A. Lorentzen (1749–1828). With permission from the University of Copenhagen.</p><p>We apologize for this error.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70113","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143835801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RNA-Based Therapies for Neurodegenerative Diseases Targeting Pathogenic Proteins","authors":"Syed Arman Rabbani,&nbsp;Mohamed El-Tanani,&nbsp;Shrestha Sharma,&nbsp;Yahia El-Tanani,&nbsp;Rakesh Kumar,&nbsp;Manita Saini,&nbsp;Monu Yadav,&nbsp;Mohammad Ahmed Khan,&nbsp;Suhel Parvez","doi":"10.1111/ejn.70110","DOIUrl":"https://doi.org/10.1111/ejn.70110","url":null,"abstract":"<div>\u0000 \u0000 <p>Neurodegeneration is featured by the gradual stagnation of neuronal function and structure, leading to significant motor and cognitive impairments. The primary histopathological features underlying these conditions include the cumulation of pathological protein aggregates, chronic inflammation, and neuronal cell death. Alzheimer's disease (<span>AD</span>) and Parkinson's disease (PD) are prominent examples of neurodegenerative diseases (NDDs). As of 2023, over 65 million people worldwide are affected by <span>AD</span> and PD, with the prevalence of these conditions steadily increasing over time. Interestingly, there are no effective therapies available to halt or slow NDD progression. Most approved treatments are focused on symptom management and are often associated with substantial side effects. Given these limitations, the development of novel therapeutic approaches targeting the molecular mechanisms underlying these disorders is essential. Notably, RNA-based therapeutics have recently emerged as a potential therapeutic approach for managing various neurological diseases, offering the potential for innovative molecular interventions in NDD. In this review, we have discussed the pathogenic role of various protein aggregates in NDD and highlighted emerging RNA-based strategies aimed at targeting these pathological proteins.</p>\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143835805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whispers in the Brain: Extracellular Vesicles in Neuropathology and the Diagnostic Alchemy of Neurological Diseases","authors":"Melis Isik,&nbsp;Hatice Kubra Sari,&nbsp;Mehmet Gokhan Caglayan,&nbsp;Rezzak Yilmaz,&nbsp;Burak Derkus","doi":"10.1111/ejn.70090","DOIUrl":"https://doi.org/10.1111/ejn.70090","url":null,"abstract":"<div>\u0000 \u0000 <p>Extracellular vesicles (EVs) have emerged as pivotal mediators in neurological diseases, showcasing multifaceted potential roles ranging from pathogenesis to diagnosis. These nano-sized membranous structures, released by various cell types including neurons, astrocytes, and microglia, encapsulate a diverse cargo of proteins, lipids, RNA species, and even DNA fragments. In neuropathology, EVs contribute significantly to intercellular communication within the central nervous system (CNS), influencing physiological or pathological cascades. Through the transfer of bioactive molecules, EVs modulate neuroinflammation, neuronal survival, synaptic plasticity, and the propagation of protein aggregates characteristic of neurodegenerative disorders. Moreover, their presence in biofluids such as cerebrospinal fluid (CSF), blood, and urine reflects the pathophysiological state of the CNS, offering a window into the diagnosis, monitoring and treatment of neurological diseases. Recent advancements in EV isolation techniques, coupled with high-throughput omics technologies, have facilitated the profiling of EV cargo, enabling the identification of disease-specific biomarkers with high sensitivity and specificity. This review explores the intricate roles of EVs in neuropathology, highlighting their involvement in Alzheimer's disease, Parkinson's disease, multiple sclerosis, and other neurological disorders. Furthermore, it delves into the diagnostic potential of EVs, discussing current challenges and prospects in harnessing EV-derived biomarkers for precision medicine in neurology. Ultimately, understanding the biology of EVs in neurological contexts promises transformative insights into disease mechanisms and therapeutic strategies, paving the way for innovative diagnostic tools and targeted interventions in clinical practice.</p>\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 8","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143835803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward an Automatic Classification of the Different Stages of Sleep: Exploring Patterns of Neural Activity in the Subthalamic Nucleus","authors":"Nathan Barbe,&nbsp;Mark Connolly,&nbsp;Annaelle Devergnas,&nbsp;Napoleon Torrès,&nbsp;Marrio Hervault,&nbsp;Mathieu Bonis,&nbsp;Malvina Billères,&nbsp;Stephan Chabardes,&nbsp;Brigitte Piallat","doi":"10.1111/ejn.70107","DOIUrl":"https://doi.org/10.1111/ejn.70107","url":null,"abstract":"<p>Sleep disorders substantially impact quality of life, especially in patients with neurodegenerative diseases like Parkinson's disease. Recent advances in deep brain stimulation highlight the potential of closed-loop adaptive stimulation that utilizes neural feedback signals recorded directly from the stimulation electrodes. The subthalamic nucleus, a distinct structure located deep in the brain, plays a major role in processing cortical information and could be used to classify sleep stages. We recorded local field potentials in the subthalamic nucleus of two freely moving nonhuman primates across three nights. Our study examined subthalamic neuronal activity across different vigilance stages using spectral activity, multiscale entropy analysis, and an automatic classification. Results revealed distinct spectral patterns in subthalamic activity corresponding to sleep stages, with a high synchronization between subthalamic nucleus and EEG signals during deeper sleep stages. These deeper stages were associated also with reduced entropy, suggesting decreased neural activity complexity. An automated machine learning classifier based on subthalamic nucleus spectral activity distinguished wakefulness from sleep with high accuracy (94% for both animals). While the classifier performed well for deeper sleep stages, its accuracy was lower for lighter sleep stages. Our findings suggest that subthalamic nucleus activity can mirror cortical dynamics during sleep, supporting its potential use in developing closed-loop stimulation therapies for sleep disorders. This work provides a foundation for further studies in Parkinson's disease models to evaluate the translational relevance of subthalamic nucleus activity in clinical applications.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamically Adjusting Intertemporal Choice Task in Rodents","authors":"Morteza Salimi,&nbsp;Milad Nazari,&nbsp;Miranda Francoeur Koloski,&nbsp;Samuel A. Barnes,&nbsp;Jonathan Mishler,&nbsp;Sahar Jomehpour,&nbsp;Dhakshin S. Ramanathan","doi":"10.1111/ejn.70104","DOIUrl":"https://doi.org/10.1111/ejn.70104","url":null,"abstract":"<div>\u0000 \u0000 <p>Temporal discounting refers to the tendency for immediate rewards over delayed ones, assessed through intertemporal choice tasks where subjects choose between immediate low-value or delayed high-value rewards. Traditional rodent tasks often require extensive pre-task training, introducing species-specific biases and thus lower translational utility. We present a novel dynamically adjusting intertemporal choice task, where the delay for a large reward adjusts trial-by-trial based on prior choices. Choosing the large reward increases its delay by 500 ms, while selecting the small reward decreases the large reward delay by 500 ms. In eight Long–Evans rats tested across 50 days, key behavioral measures stabilized early, including the average delay and preference for the large reward. However, training enhanced behavioral flexibility, allowing rats to optimize rewards over time. This task enables rapid assessment of delay preferences while also revealing cognitive flexibility, offering significant advantages for investigating decision-making that may be relevant to real-world behaviors.</p>\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143822187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Development of the Auditory Brainstem Nuclei During Embryogenesis of the Mouse Revealed by Optical Recording With a Voltage-Sensitive Dye","authors":"Yoko Momose-Sato,&nbsp;Katsushige Sato","doi":"10.1111/ejn.70106","DOIUrl":"https://doi.org/10.1111/ejn.70106","url":null,"abstract":"<div>\u0000 \u0000 <p>A fundamental question in auditory neuroscience is when and how complex connections between the nuclei/centers are organized during ontogenesis. In the present study, we applied a multiple-site optical recording technique with a voltage-sensitive dye and surveyed the developmental organization of the auditory system in the mouse embryo. Stimulation of the cochlear (auditory) nerve elicited excitatory postsynaptic potential (EPSP)-related optical responses in the lateral brainstem, which corresponded to the auditory sensory nucleus, namely, the cochlear nucleus. The EPSP was mediated by glutamate and mainly dependent on <i>N</i>-methyl-d-aspartate (NMDA) receptors. The EPSP was first detected at E (embryonic day) 12, indicating that functional connections between the periphery and neurons in the cochlear nucleus are established at this stage. At later developmental stages, cochlear nerve stimulation elicited additional postsynaptic responses in the ipsilateral and contralateral ventral brainstem, which corresponded to the higher center of the auditory pathway, the superior olivary complex (SOC). The EPSP in the SOC was detected from E15 in normal physiological solution and E14 in a Mg²⁺-free solution. Thus, the synaptic connections between the cochlear nucleus and the SOC are established by E14, but they are suppressed by the Mg²⁺ block on the NMDA receptors before E15. Overall, our results suggest that postsynaptic responses in the cochlear nucleus and the SOC exhibit much earlier than previously reported, and functional synapses are generated soon after the arrival of afferent fibers and before morphological differentiation of the brainstem nuclei has been completed.</p>\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 7","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143822189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}