European Journal of Neuroscience最新文献

{"title":"Early movement restriction impairs the development of sensorimotor integration, motor skills and memory in rats: Towards a preclinical model of developmental coordination disorder?","authors":"Hanane Khalki,&nbsp;Diego Cabral Lacerda,&nbsp;Corane Karoutchi,&nbsp;Maxime Delcour,&nbsp;Orlane Dupuis,&nbsp;Marine Kochmann,&nbsp;Jean-Michel Brezun,&nbsp;Erwan Dupont,&nbsp;Mamta Amin,&nbsp;Muriel Darnaudéry,&nbsp;Marie-Hélène Canu,&nbsp;Mary F. Barbe,&nbsp;Jacques-Olivier Coq","doi":"10.1111/ejn.16594","DOIUrl":"10.1111/ejn.16594","url":null,"abstract":"<p>Children with neurodevelopmental disorders, such as developmental coordination disorder (DCD), exhibit gross to fine sensorimotor impairments, reduced physical activity and interactions with the environment and people. This disorder co-exists with cognitive deficits, executive dysfunctions and learning impairments. Previously, we demonstrated in rats that limited amounts and atypical patterns of movements and somatosensory feedback during early movement restriction manifested in adulthood as degraded postural and locomotor abilities, and musculoskeletal histopathology, including muscle atrophy, hyperexcitability within sensorimotor circuitry and maladaptive cortical plasticity, leading to functional disorganization of the primary somatosensory and motor cortices in the absence of cortical histopathology. In this study, we asked how this developmental sensorimotor restriction (SMR) started to impact the integration of multisensory information and the emergence of sensorimotor reflexes in rats. We also questioned the enduring impact of SMR on motor activities, pain and memory. SMR led to deficits in the emergence of swimming and sensorimotor reflexes, the development of pain and altered locomotor patterns and posture with toe-walking, adult motor performance and night spontaneous activity. In addition, SMR induced exploratory hyperactivity, short-term impairments in object-recognition tasks and long-term deficits in object-location tasks. SMR rats displayed minor alterations in histological features of the hippocampus, entorhinal, perirhinal and postrhinal cortices yet no obvious changes in the prefrontal cortex. Taken all together, these results show similarities with the symptoms observed in children with DCD, although further exploration seems required to postulate whether developmental SMR corresponds to a rat model of DCD.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"60 11","pages":"6830-6850"},"PeriodicalIF":2.7,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.16594","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Female Wistar Kyoto More Immobile rats with genetic stress hyper-reactivity show enhanced contextual fear memory without deficit in extinction of fear","authors":"Aspen M. Harter,&nbsp;Mariya Nemesh,&nbsp;Michelle T. Ji,&nbsp;Luca Lee,&nbsp;Anna Yamazaki,&nbsp;Chris Kim,&nbsp;Eva E. Redei","doi":"10.1111/ejn.16595","DOIUrl":"10.1111/ejn.16595","url":null,"abstract":"<p>The prevalence of post-traumatic stress disorder (PTSD) is higher in females than males, but pre-clinical models are established almost exclusively in males. This study is aimed to investigate the stress-enhanced fear learning model of PTSD in females. The model mirrors PTSD symptomology in males, whereby prior stress leads to extinction resistant exaggerated contextual fear memory. As stress reactivity is highly relevant to the study and risk for PTSD, females of the stress hyper-reactive Wistar Kyoto More Immobile (WMI) and its nearly isogenic control the Wistar Kyoto Less Immobile (WLI) strains were employed. Prior studies have shown WMI females presenting unchanged or enhanced fear memory in the stress-enhanced fear learning paradigm compared WLIs. The present study confirmed the enhanced fear memory following contextual fear conditioning in WMIs compared to WLI females, but this increased fear memory was neither exaggerated by prior stress nor showed extinction deficit. The novel stressor of a glucose challenge test resulted in subtle strain- and prior stress-induced differences in plasma glucose responses. However, fasting plasma corticosterone levels were lower, and rose slower in response to glucose challenge in WMI females, suggesting a PTSD-like dysfunctional stress response. Hippocampal expressions of genes relevant to both learning and memory and the stress response were decreased in stressed WMIs compared to WLI females, further suggesting a marked dysregulation in stress-related functions like in PTSD. Thus, although WMI females do not show extinction-resistant enhanced fear memory, they do present other characteristics that are relevant to PTSD in women.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"60 11","pages":"6851-6865"},"PeriodicalIF":2.7,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.16595","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Connectome-based predictive modelling of ageing, overall cognitive functioning and memory performance","authors":"Yi Gu,&nbsp;Lianghu Guo,&nbsp;Xinyi Cai,&nbsp;Qing Yang,&nbsp;Jian Sun,&nbsp;Yufei Li,&nbsp;Jiayu Zhu,&nbsp;Weijun Zhang,&nbsp;Peiyu Huang,&nbsp;Yi Jiang,&nbsp;Bin Bo,&nbsp;Yao Li,&nbsp;Yaoyu Zhang,&nbsp;Minming Zhang,&nbsp;Jinsong Wu,&nbsp;Hongcheng Shi,&nbsp;Siwei Liu,&nbsp;Qiang He,&nbsp;Xing Yao,&nbsp;Qiang Zhang,&nbsp;Hongjiang Wei,&nbsp;Xu Zhang,&nbsp;Han Zhang,&nbsp;the Consortium of Chinese Brain Molecular and Functional Mapping (CBMFM)","doi":"10.1111/ejn.16559","DOIUrl":"10.1111/ejn.16559","url":null,"abstract":"<p>Resting-state functional magnetic resonance imaging (rs-fMRI) and brain functional connectome (we use ‘brain connectome’ hereafter for simplicity) have advanced our understanding of the ageing brain and age-related changes in cognitive function. Previous studies have investigated the association among brain connectome and age, global cognition, and memory function separately. However, very few have predicted age, overall cognitive functioning and memory performance in a single study to better understand their complex relationship. In this cross-sectional study, we applied an exploratory, data-driven method to investigate the brain connectome markers that could predict ageing, overall cognitive functioning assessed as intelligence quotient (IQ, measured by Wechsler Memory Scale) and memory performance assessed as memory quotient (MQ, measured by Wechsler Memory Scale) in a carefully designed, multicentre, normal ageing cohort (<i>n</i> = 313). Our results showed that brain connectome could predict ageing and IQ, but the association with MQ was weak. We found that the connectivity with orbital frontal cortex was associated with both ageing and IQ. Mediation analysis further showed that the brain connectome mediated the relationship between age and overall cognitive functioning, suggesting a protective brain connectomic mechanism for maintaining normal cognitive functions during healthy ageing. This work may shed light on the potential neural correlates of healthy ageing, overall cognitive functioning and memory performance.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"60 11","pages":"6812-6829"},"PeriodicalIF":2.7,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thoughts on mentoring trainees in neuroscience","authors":"Peter Scheiffele","doi":"10.1111/ejn.16608","DOIUrl":"10.1111/ejn.16608","url":null,"abstract":"&lt;p&gt;Enabling trainees to grow and develop as researchers is one of the most rewarding and joyful aspects of being a scientist! While impact and success are driven by the capabilities and motivation of the trainees themselves, mentors can contribute to their professional trajectory in the lab as a foundation for their future career and contributions.&lt;/p&gt;&lt;p&gt;I believe successful mentoring relationships are built on trust, respect and open communication. Another key ingredient is a shared genuine enthusiasm for science. Many important discoveries arise from experiments that test provocative hypotheses or push limits of technology. To embark on such a journey, trainees need to think big, dream a bit and take risks. Thus, a critical aspect of mentoring involves creating an environment where trainees feel safe and appreciated, learn to evaluate and balance risks and are empowered to pursue an ambitious vision. Of course, this also involves to work together on a back-up plan in case there are obstacles that cannot be overcome.&lt;/p&gt;&lt;p&gt;Another major role for mentors is to communicate enduring values for building rigorous and innovative research programs and for adopting a generous and constructive research culture. How do you choose a good question that is productive but—at the same time—not a purely opportunistic activity that is unlikely to provide fundamental insights? Fostering a respectful culture—being inclusive about recognizing contributions by others—demands increasing effort considering the ever-increasing volume of scientific output all over the globe.&lt;/p&gt;&lt;p&gt;Every laboratory has its own strategies for day-to-day mentoring on how to define an exciting project, write scholarly papers, give inspiring talks, or coach trainees for job applications. That being said, often, the most powerful advice is from experienced individuals who are working outside one's immediate topic area. They offer a fresh perspective and focus on the first principles, breaking down complex problems to their most fundamental elements. Thus, it is important to build structures in a department that facilitate such mentoring interactions, from opportunities for frequent informal dialogue to more formal coaching arrangements. To make this work, mentors need to be approachable and dedicate time to the interaction with trainees outside their groups. At the same time, they should also support their own trainees in seeking advice from suitable outside colleagues.&lt;/p&gt;&lt;p&gt;One final remark that I often make to my students is that in academic science, we are quite privileged: I feel that in business environments, schedules are much less flexible, and there is a more conformist expectation on style to maximize the commercial mission of the entity. At academic institutions, trainees can experience various successful role models along the way. When comparing these individuals, our trainees tend to realize the wide range of leadership and mentoring styles—each of them successful but fundamental","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"60 11","pages":"6874"},"PeriodicalIF":2.7,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.16608","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142617293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evolucollateral dynamics in stroke: Evolutionary pathophysiology, remodelling and emerging therapeutic strategies","authors":"Akansha Sinha,&nbsp;Muskaan Gupta,&nbsp;Sonu M. M. Bhaskar","doi":"10.1111/ejn.16585","DOIUrl":"10.1111/ejn.16585","url":null,"abstract":"<p>Leptomeningeal collaterals (LMCs) are crucial in mitigating the impact of acute ischemic stroke (AIS) by providing alternate blood flow routes when primary arteries are obstructed. This article explores the evolutionary pathophysiology of LMCs, highlighting their critical function in stroke and the genetic and molecular mechanisms governing their development and remodelling. We address the translational challenges of applying animal model findings to human clinical scenarios, emphasizing the need for further research to validate emerging therapies—such as pharmacological agents, gene therapy and mechanical interventions—in clinical settings, aimed at enhancing collateral perfusion. Computational modelling emerges as a promising method for integrating experimental data, which requires precise parameterization and empirical validation. We introduce the ‘Evolucollateral Dynamics’ hypothesis, proposing a novel framework that incorporates evolutionary biology principles into therapeutic strategies, offering new perspectives on enhancing collateral circulation. This hypothesis emphasizes the role of genetic predispositions and environmental influences on collateral circulation, which may impact therapeutic strategies and optimize treatment outcomes. Future research must incorporate human clinical data to create robust treatment protocols, thereby maximizing the therapeutic potential of LMCs and improving outcomes for stroke patients.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"60 11","pages":"6779-6798"},"PeriodicalIF":2.7,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Central amygdala-to-pre-Bötzinger complex neurotransmission is direct and inhibitory","authors":"Jeffrey Gu,&nbsp;Yae K. Sugimura,&nbsp;Fusao Kato,&nbsp;Christopher A. Del Negro","doi":"10.1111/ejn.16589","DOIUrl":"10.1111/ejn.16589","url":null,"abstract":"<p>Breathing behaviour is subject to emotional regulation, but the underlying mechanisms remain unclear. Here, we demonstrate a direct relationship between the central amygdala, a major output hub of the limbic system associated with emotional brain function, and the brainstem pre-Bötzinger complex, which generates the fundamental rhythm and pattern for breathing. The connection between these two sites is monosynaptic and inhibitory, involving GABAergic central amygdala neurons whose axonal projections act predominantly via ionotropic GABA_A receptors to produce inhibitory postsynaptic currents in pre-Bötzinger neurons. This pathway may provide a mechanism to inhibit breathing in the context of freezing to assess threats and plan defensive action. The existence of this pathway may further explain how epileptic seizures invading the amygdala cause long-lasting apnea, which can be fatal. Although their ultimate importance awaits further behavioural tests, these results elucidate a link between emotional brain function and breathing, which underlies survival-related behaviour in mammals and pertains to human anxiety disorders.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"60 11","pages":"6799-6811"},"PeriodicalIF":2.7,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.16589","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optogenetic activation of mesencephalic projections to the nucleus accumbens shell impairs probabilistic reversal learning by disrupting learning from negative reinforcement","authors":"Katharina Zühlsdorff,&nbsp;Júlia Sala-Bayo,&nbsp;Sammy Piller,&nbsp;Peter Zhukovsky,&nbsp;Thorsten Lamla,&nbsp;Wiebke Nissen,&nbsp;Moritz von Heimendahl,&nbsp;Serena Deiana,&nbsp;Janet R. Nicholson,&nbsp;Trevor W. Robbins,&nbsp;Johan Alsiö,&nbsp;Jeffrey W. Dalley","doi":"10.1111/ejn.16584","DOIUrl":"10.1111/ejn.16584","url":null,"abstract":"<p>Cognitive flexibility, the capacity to adapt behaviour to changes in the environment, is impaired in a range of brain disorders, including schizophrenia and Parkinson's disease. Putative neural substrates of cognitive flexibility include mesencephalic pathways to the ventral striatum (VS) and dorsomedial striatum (DMS), hypothesized to encode learning signals needed to maximize rewarded outcomes during decision-making. However, it is unclear whether mesencephalic projections to the ventral and dorsal striatum are distinct in their contribution to flexible reward-related learning. Here, rats acquired a two-choice spatial probabilistic reversal learning (PRL) task, reinforced on an 80%|20% basis (correct|incorrect responses) that assessed the flexibility of behaviour to repeated reversals of response-outcome contingencies. We report that optogenetic stimulation of projections from the ventral tegmental area (VTA) to the nucleus accumbens shell (NAcS) in the VS significantly impaired reversal learning when optical stimulation was temporally aligned with negative feedback (i.e., reward omission). VTA → NAcS stimulation during other phases of the behavioural task was without significant effect. Optogenetic stimulation of projection neurons from the substantia nigra (SN) to the DMS, aligned either with reward receipt or omission or prior to making a choice, had no significant effect on reversal learning. These findings are consistent with the notion that increased activity in the VTA → NAcS pathway disrupts behavioural flexibility by impairing learning from negative reinforcement.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"60 11","pages":"6765-6778"},"PeriodicalIF":2.7,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.16584","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The alteration of serotonergic markers in the amygdala and raphe nuclei of oestrogen receptor β knock-out female mice","authors":"Daniel Kalinowski,&nbsp;Krystyna Bogus-Nowakowska","doi":"10.1111/ejn.16580","DOIUrl":"10.1111/ejn.16580","url":null,"abstract":"<p>The amygdala and raphe nuclei, which play crucial roles in mood regulation, are influenced by serotonergic neurotransmission. Alterations in this neurotransmission are associated with mood disorders. Therefore, using immunohistochemistry and quantitative methods this study was designed to evaluate potential alterations in the expression of serotoninergic markers in the amygdala and raphe nuclei of mice with oestrogen receptor β (ERβ) knock out which exhibit increased anxiety as evidenced by reduced locomotion and increased thigmotaxis. These alterations could either contribute to heightened anxiety or serve as a compensatory strategy for reducing it. The results show that in ERβ knock-out mice, 5-HT1B expression is significantly increased in the amygdala, while 5-HTT expression is significantly decreased in both the amygdala and raphe nuclei. Furthermore, ERβ deficiency does not affect TPH2. In conclusion, serotonin signalling is altered in the amygdala and raphe nuclei of ERβ knock-out females. It seems that an increase in 5-HTT levels has been associated with reduced anxiety, whereas a decrease in 5-HT1B receptors may encourage fear. However, further studies are required to determine the exact role of ERβ in anxiety-related behaviour.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"60 11","pages":"6750-6764"},"PeriodicalIF":2.7,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural encoding of melodic expectations in music across EEG frequency bands","authors":"Juan-Daniel Galeano-Otálvaro,&nbsp;Jordi Martorell,&nbsp;Lars Meyer,&nbsp;Lorenzo Titone","doi":"10.1111/ejn.16581","DOIUrl":"10.1111/ejn.16581","url":null,"abstract":"<p>The human brain tracks regularities in the environment and extrapolates these to predict future events. Prior work on music cognition suggests that low-frequency (1–8 Hz) brain activity encodes melodic predictions beyond the stimulus acoustics. Building on this work, we aimed to disentangle the frequency-specific neural dynamics linked to melodic prediction uncertainty (modelled as entropy) and prediction error (modelled as surprisal) for temporal (note onset) and content (note pitch) information. By using multivariate temporal response function (TRF) models, we re-analysed the electroencephalogram (EEG) from 20 subjects (10 musicians) who listened to Western tonal music. Our results show that melodic expectation metrics improve the EEG reconstruction accuracy in all frequency bands below the gamma range (&lt; 30 Hz). Crucially, we found that entropy contributed more strongly to the reconstruction accuracy enhancement compared to surprisal in all frequency bands. Additionally, we found that the encoding of temporal, but not content, information metrics was not limited to low frequencies, rather it extended to higher frequencies (&gt; 8 Hz). An analysis of the TRF weights revealed that the temporal predictability of a note (entropy of note onset) may be encoded in the delta- (1–4 Hz) and beta-band (12–30 Hz) brain activity prior to the stimulus, suggesting that these frequency bands associate with temporal predictions. Strikingly, we also revealed that melodic expectations selectively enhanced EEG reconstruction accuracy in the beta band for musicians, and in the alpha band (8–12 Hz) for non-musicians, suggesting that musical expertise influences the neural dynamics underlying predictive processing in music cognition.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"60 11","pages":"6734-6749"},"PeriodicalIF":2.7,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.16581","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential modulations of theta and beta oscillations by audiovisual congruency in letter-speech sound integration","authors":"Dongyang Yan,&nbsp;Ayumi Seki","doi":"10.1111/ejn.16563","DOIUrl":"10.1111/ejn.16563","url":null,"abstract":"<p>The integration of visual letters and speech sounds is a crucial part of learning to read. Previous studies investigating this integration have revealed a modulation by audiovisual (AV) congruency, commonly known as the congruency effect. To investigate the cortical oscillations of the congruency effects across different oscillatory frequency bands, we conducted a Japanese priming task in which a visual letter was followed by a speech sound. We analyzed the power and phase properties of oscillatory activities in the theta and beta bands between congruent and incongruent letter-speech sound (L-SS) pairs. Our results revealed stronger theta-band (5–7 Hz) power in the congruent condition and cross-modal phase resetting within the auditory cortex, accompanied by enhanced inter-trial phase coherence (ITPC) in the auditory-related areas in response to the congruent condition. The observed congruency effect of theta-band power may reflect increased neural activities in the left auditory region during L-SS integration. Additionally, theta ITPC findings suggest that visual letters amplify neuronal responses to the following corresponding auditory stimulus, which may reflect the differential cross-modal influences in the primary auditory cortex. In contrast, decreased beta-band (20–35 Hz) oscillatory power was observed in the right centroparietal regions for the congruent condition. The reduced beta power seems to be unrelated to the processing of AV integration, but may be interpreted as the brain response to predicting auditory sounds during language processing. Our data provide valuable insights by indicating that oscillations in different frequency bands contribute to the disparate aspects of L-SS integration.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"60 11","pages":"6720-6733"},"PeriodicalIF":2.7,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142521447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}