European Journal of Neuroscience最新文献_第9页

The Possibility Space Concept in Neuroscience: Possibilities, Constraints, and Explanations 神经科学中的可能性空间概念：可能性、限制和解释

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-12 DOI: 10.1111/ejn.70038

Lauren N. Ross, Viktor Jirsa, Anthony R. McIntosh

{"title":"The Possibility Space Concept in Neuroscience: Possibilities, Constraints, and Explanations","authors":"Lauren N. Ross, Viktor Jirsa, Anthony R. McIntosh","doi":"10.1111/ejn.70038","DOIUrl":"https://doi.org/10.1111/ejn.70038","url":null,"abstract":"Although the brain is often characterized as a complex system, theoretical and philosophical frameworks often struggle to capture this. For example, mainstream mechanistic accounts model neural systems as fixed and static in ways that fail to capture their dynamic nature and large set of possible behaviors. In this paper, we provide a framework for capturing a common type of complex system in neuroscience, which involves two main aspects: (i) constraints on the system and (ii) the system's possibility space of available outcomes. Our analysis merges neuroscience examples with recent work in the philosophy of science to suggest that the possibility space concept involves two essential types of constraints, which we call hard and soft constraints. Our analysis focuses on a domain-general notion of possibility space that is present in manifold frameworks and representations, phase space diagrams in dynamical systems theory, and paradigmatic cases, such as Waddington's epigenetic landscape model. After building the framework with such cases, we apply it to three main examples in neuroscience: adaptability, resilience, and phenomenology. We explore how this framework supports a philosophical toolkit for neuroscience and how it helps advance recent work in the philosophy of science on constraints, scientific explanations, and impossibility explanations. We show how fruitful connections between neuroscience and philosophy can support conceptual clarity, theoretical advances, and the identification of similar systems across different domains in neuroscience.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143602829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implicit Motor Learning Under Anodal or Cathodal tDCS During fMRI Induces Partially Distinct Network Responses 内隐运动学习在阳极或阴极tDCS下诱发部分不同的网络反应

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-12 DOI: 10.1111/ejn.70053

Farsin Hamzei, Alexander Ritter, Daniel Güllmar

{"title":"Implicit Motor Learning Under Anodal or Cathodal tDCS During fMRI Induces Partially Distinct Network Responses","authors":"Farsin Hamzei, Alexander Ritter, Daniel Güllmar","doi":"10.1111/ejn.70053","DOIUrl":"https://doi.org/10.1111/ejn.70053","url":null,"abstract":"How anodal transcranial direct current stimulation (atDCS) and cathodal tDCS (ctDCS) affect brain networks is still unclear. Previous fMRI studies have yielded controversial results regarding the effects of atDCS and ctDCS on fMRI activation. The present study hypothesizes that the choice of fMRI paradigm may be a contributing factor to this divergence. Therefore, the present study employed two distinct fMRI paradigms, characterized by varying degrees of complexity: finger tapping as a simple fMRI paradigm and an implicit serial reaction time task (SRTT) as a more challenging paradigm. Seventy-five healthy subjects were randomized to receive either atDCS, ctDCS, or sham stimulation during fMRI. The main effects of the blood oxygenation level–dependent (BOLD) signal were contrasted between groups. SRTT, but not FT, was capable of eliciting differences in modulatory effects on the network between groups. Analysis of functional connectivity between ROIs showed that atDCS and ctDCS shared common and distinct SRTT networks. Correlations between BOLD signal (in ROIs) and the reaction time (RT) recorded during fMRI showed that in the atDCS group, faster RT was associated with higher BOLD signal in the most ROIs, while in the ctDCS group, faster RT was mostly associated with lower BOLD signal activity. The sham group exhibited a combination of these associations. We suggest that atDCS accelerates RT by “pushing” the network, while the network response under ctDCS was a “compensatory” response. The polarity of tDCS differentially modulated the adaptive plasticity of remotely connected regions, based on the concept of functional organization of distributed segregated networks.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143602830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Forestwalk: A Machine Learning Workflow Brings New Insights Into Posture and Balance in Rodent Beam Walking 森林行走：机器学习工作流程为啮齿动物梁行走的姿势和平衡带来了新的见解

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-11 DOI: 10.1111/ejn.70033

Francesca Tozzi, Yan-Ping Zhang, Ramanathan Narayanan, Damian Roqueiro, Eoin C. O'Connor

{"title":"Forestwalk: A Machine Learning Workflow Brings New Insights Into Posture and Balance in Rodent Beam Walking","authors":"Francesca Tozzi, Yan-Ping Zhang, Ramanathan Narayanan, Damian Roqueiro, Eoin C. O'Connor","doi":"10.1111/ejn.70033","DOIUrl":"https://doi.org/10.1111/ejn.70033","url":null,"abstract":"The beam walk is widely used to study coordination and balance in rodents. While the task has ethological validity, the main endpoints of “foot slip counts” and “time to cross” are prone to human-rater variability and offer limited sensitivity and specificity. We asked if machine learning–based methods could reveal previously hidden, but biologically relevant, insights from the task. Marker-less pose estimation, using DeepLabCut, was deployed to label 13 anatomical key points on mice traversing the beam. Next, we automated classical endpoint detection, including foot slips, with high recall (> 90%) and precision (> 80%). Using data derived from key point tracking, a total of 395 features were engineered and a random forest classifier deployed that, together with skeletal visualizations, could test for group differences and identify determinant features. This workflow, named Forestwalk, uncovered pharmacological treatment effects in C57BL/6J mice, revealed phenotypes in transgenic mice used to study Angelman syndrome and SLC6A1-related neurodevelopmental disorder, and will facilitate a deeper understanding of how the brain controls balance in health and disease.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation of the Impact of Motor, Nonmotor, Cognitive, and Psychometric Features on Freezing of Gait in Parkinson's Disease 运动、非运动、认知和心理特征对帕金森病步态冻结影响的研究

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-11 DOI: 10.1111/ejn.70044

Halil Onder, Ali Aydogan, Aycan Cemil Ulker, Selcuk Comoglu

{"title":"Investigation of the Impact of Motor, Nonmotor, Cognitive, and Psychometric Features on Freezing of Gait in Parkinson's Disease","authors":"Halil Onder, Ali Aydogan, Aycan Cemil Ulker, Selcuk Comoglu","doi":"10.1111/ejn.70044","DOIUrl":"https://doi.org/10.1111/ejn.70044","url":null,"abstract":"<div>\u0000 \u0000 There are still debates regarding the pathophysiology of freezing of gait (FOG) in Parkinson's disease (PD). This study aims to investigate the potential contribution of the nonmotor symptoms in the pathophysiology of FOG. This was a cross-sectional observational cohort study where we enrolled all consecutive PD patients who applied to our movement disorders outpatient clinics at Etlik City Hospital, Ankara, Turkey, between January 2024 and August 2024. We performed comprehensive assessments including scales to evaluate both motor and nonmotor features, psychometric properties, and cognitive characteristics. In the hierarchical regression analyses, we sought to examine the contributory role of the motor, nonmotor, neuropsychological, and cognitive symptom load on FOG one by one. We included 45 PD patients with a mean age of 61.9 ± 8.6. The median disease duration was 5 years (range: 20), the median MDS-UPDRS-3-off score was 33 (range: 20.5). The comparative analyses between patients with (n = 21) and without FOG (n = 24) revealed that the scores regarding the MDS-UPDRS-1 (p = 0.04), MDS-UPDRS-3 (p = 0.00), MDS-UPDRS-3-axial subscore (p = 0.00), NMSS (p = 0.017), SMMSE (p = 0.02), forward counting (p = 0.044), backward counting (p = 0.015), JLO (p = 0.033), HAM-A (p = 0.006), and HDRS (p = 0.006) were all higher in the FOG (+) group. In the hierarchical regression analyses, the MDS-UPDRS-3-off score was the only predictive factor of FOG severity in the model evaluating the motor factors (B = 0.251, p = 0.000) and also the other models which we included the other nonmotor features one by one. Our findings showed that nonmotor symptoms, cognitive functions, and psychometric properties do not provide a contributory effect to the motor severity on the FOG severity.\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GABA and Glycine Synaptic Release on Axotomized Motoneuron Cell Bodies Promotes Motor Axon Regeneration 运动神经元胞体上GABA和甘氨酸突触释放促进运动轴突再生

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-11 DOI: 10.1111/ejn.70045

Ryan L. Wood, Paula M. Calvo, William M. McCallum, Arthur W. English, Francisco J. Alvarez

{"title":"GABA and Glycine Synaptic Release on Axotomized Motoneuron Cell Bodies Promotes Motor Axon Regeneration","authors":"Ryan L. Wood, Paula M. Calvo, William M. McCallum, Arthur W. English, Francisco J. Alvarez","doi":"10.1111/ejn.70045","DOIUrl":"https://doi.org/10.1111/ejn.70045","url":null,"abstract":"<div>\u0000 \u0000 Motor axon regeneration after traumatic nerve injuries is a slow process that adversely influences patient outcomes because muscle reinnervation delays result in irreversible muscle atrophy and suboptimal axon regeneration. This advocates for investigating methods to accelerate motor axon growth. Electrical nerve stimulation and exercise both enhance motor axon regeneration in rodents and patients, but these interventions cannot always be easily implemented. A roadblock to uncover novel therapeutic approaches based on the effects of activity is the lack of understanding of the synaptic drives responsible for activity-mediated facilitation of axon regeneration. We hypothesized that the relevant excitatory inputs facilitating axon regrowth originate in GABA/glycine synapses, which become depolarizing after downregulation of the potassium chloride cotransporter 2 in motoneurons following axotomy. To test this, we injected tetanus toxin (TeTx) into the tibialis anterior (TA) muscle of mice to block the release of GABA/glycine specifically onto TA motoneurons. Thereafter, we axotomized all sciatic motoneurons by nerve crush and analyzed the time courses of muscle reinnervation in TeTx-treated (TA) and untreated (lateral gastrocnemius [LG]) motoneurons. Muscle reinnervation was slower in TA motoneurons with blocked GABA/glycine synapses, as measured by recovery of M responses and anatomical reinnervation of neuromuscular junctions. Post hoc immunohistochemistry confirmed the removal of the vesicle-associated membrane proteins 1 and 2 by TeTx activity, specifically from inhibitory synapses. These proteins are necessary for the exocytotic release of neurotransmitters. Therefore, we conclude that GABA/glycine neurotransmission on regenerating motoneurons facilitates axon growth and muscle reinnervation, and we discuss possible interventions to modulate these inputs on regenerating motoneurons.\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Olfactory Receptor Responses to Pure Odorants in Drosophila melanogaster 黑腹果蝇嗅觉受体对纯气味的反应

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-10 DOI: 10.1111/ejn.70036

Alja Lüdke, Ajayrama Kumaraswamy, C. Giovanni Galizia

{"title":"Olfactory Receptor Responses to Pure Odorants in Drosophila melanogaster","authors":"Alja Lüdke, Ajayrama Kumaraswamy, C. Giovanni Galizia","doi":"10.1111/ejn.70036","DOIUrl":"https://doi.org/10.1111/ejn.70036","url":null,"abstract":"Olfactory coding relies on primary information from olfactory receptor cells that respond to volatile airborne substances. Despite extensive efforts, our understanding of odor-response profiles across receptors is still poor, because of the vast number of possible ligands (odorants), the high sensitivity even to trace compounds (creating false positive responses), and the diversity of olfactory receptors. Here, we linked chemical purification with a gas chromatograph to single-receptor type recording with transgenic flies using calcium imaging to record olfactory responses to a large panel of chemicals in seven Drosophila ORs: Or10a, Or13a, Or22a, Or42b, Or47a, Or56a, and Or92a. We analyze the data using linear–nonlinear modeling and reveal that most receptors have “simple” response types (mostly positive: Or10a, Or13a, Or22a, Or47a, and Or56a). However, two receptors (Or42b and Or92a) have, in addition to “simple” responses, “complex” response types to some ligands, either positive with a negative second phase or negative with a positive second phase, suggesting the presence of multiple binding sites and/or transduction cascades. We show that some ligands reported in the literature are false positives, because of contaminations in the stimulus. We recorded all stimuli across concentrations, showing that at different concentrations, different substances appear as best ligands. Our data show that studying combinatorial olfactory coding must consider temporal response properties and odorant concentration and, in addition, is strongly influenced by the presence of trace amounts of ligands (contaminations) in the samples. These observations have important repercussions for our thinking about how animals navigate their olfactory environment.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70036","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143581812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Changes in Primary Motor Cortex Organization and Associations With Changes in Motor-Sensory Tests Over Time in Relation to Low Back Pain Recovery. A Longitudinal Study 探索初级运动皮质组织的变化和运动感觉测试随时间变化与腰痛恢复的关系。一项纵向研究

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-10 DOI: 10.1111/ejn.70051

Sabrine P. Klerx, Sjoerd M. Bruijn, Michel W. Coppieters, Henri Kiers, Jos W. R. Twisk, Annelies L. Pool-Goudzwaard

{"title":"Exploring Changes in Primary Motor Cortex Organization and Associations With Changes in Motor-Sensory Tests Over Time in Relation to Low Back Pain Recovery. A Longitudinal Study","authors":"Sabrine P. Klerx, Sjoerd M. Bruijn, Michel W. Coppieters, Henri Kiers, Jos W. R. Twisk, Annelies L. Pool-Goudzwaard","doi":"10.1111/ejn.70051","DOIUrl":"https://doi.org/10.1111/ejn.70051","url":null,"abstract":"The evidence for primary motor cortex reorganization in people with low back pain varies and is conflicting. Little is known about its association with motor and sensory tests, and recovery. We investigated primary motor cortex (re)organization and its associations with motor and sensory tests over time in people with (N = 25) and without (N = 25) low back pain in a longitudinal study with a 5-week follow-up. Participants with low back pain received physical therapy. Primary motor cortex organization, including the center of gravity and area of the cortical representation of trunk muscles, was evaluated using neuronavigated transcranial magnetic stimulation, based on individual magnetic resonance imaging. A motor control test (spiral tracking test) and sensory tests (quantitative sensory testing, graphaesthesia, and 2-point discrimination) were administered. Multivariate mixed models with a 3-level structure were used. In non-recovered participants, the center of gravity of longissimus L5 moved significantly anterior, and their temporal summation of pain decreased significantly more than in people without low back pain. The spiral tracking path length decreased significantly in participants without low back pain, which differed significantly from the increase in recovered participants. Significant associations were found between center of gravity and area with quantitative sensory tests and the spiral tracking test. We found a limited number of significant changes and associations over time, mainly related to longissimus L5. For some of these findings, no logical explanation seems currently available. Hence, it is unclear whether meaningful changes in cortical organization occur in people with low back pain over a 5-week period.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Differential Monetary Rewards During Category Learning Increase Activity in Striatal Regions 在类别学习过程中，不同的金钱奖励会增加纹状体区域的活动

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-10 DOI: 10.1111/ejn.70011

Carol A. Seger, Lixue Cai, Jianping Chen, Jingxian Zhang, Zhiya Liu

{"title":"Differential Monetary Rewards During Category Learning Increase Activity in Striatal Regions","authors":"Carol A. Seger, Lixue Cai, Jianping Chen, Jingxian Zhang, Zhiya Liu","doi":"10.1111/ejn.70011","DOIUrl":"https://doi.org/10.1111/ejn.70011","url":null,"abstract":"<div>\u0000 \u0000 How is the presence of reward reflected in activity in the corticostriatal networks underlying human categorization? We examined how activity in different regions of the striatum differed on trials in which participants received a reward for correct performance versus trials with no associated reward. Participants learned to categorize abstract fractal images as members of two different categories via trial and error with feedback. Images were associated with different monetary reward values (high, low and none) that could be obtained by the participant for correct categorization. We found that neural activity in the caudate nucleus (head and body) and putamen was greater for rewarded stimuli in comparison with nonrewarded. In addition, reward resulted in greater activity across the cortical regions underlying categorization, including areas of the intraparietal sulcus (IPS) associated with stimulus-response mapping, the frontoparietal salience network and visual cortical areas associated with object and form processing. Reward effects were found both during early learning when stimuli were novel and when participants categorized stimuli on which they had been extensively trained prior to the scan. These results have implications for understanding how reward and categorization are integrated in the striatum.\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143581861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adaptive Decision-Making “Fast” and “Slow”: A Model of Creative Thinking 适应性决策“快”与“慢”：一种创造性思维模式

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-10 DOI: 10.1111/ejn.70024

Radwa Khalil, Martin Brüne

引用次数: 0

Subthalamic Activity Is Associated With Proactive Inhibition in Parkinson's Disease Patients 帕金森病患者的丘脑下活动与主动抑制有关

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-10 DOI: 10.1111/ejn.70055

Luna Damiani, Marion Albares, Pauline Laviron, Jean-Eudes Le Douget, Philippe Boulinguez, Carine Karachi, Marie-Laure Welter, Jérôme Munuera, Brian Lau

{"title":"Subthalamic Activity Is Associated With Proactive Inhibition in Parkinson's Disease Patients","authors":"Luna Damiani, Marion Albares, Pauline Laviron, Jean-Eudes Le Douget, Philippe Boulinguez, Carine Karachi, Marie-Laure Welter, Jérôme Munuera, Brian Lau","doi":"10.1111/ejn.70055","DOIUrl":"https://doi.org/10.1111/ejn.70055","url":null,"abstract":"The subthalamic nucleus (STN) is a key element of the indirect pathway of the basal ganglia (BG) and an effective target for improving motor symptoms in Parkinson's disease (PD) using deep brain stimulation (DBS). While dopamine neuron loss in PD results in a net shift towards increased inhibitory output from the BG, the precise mechanisms by which STN contributes to diminished movement remain unclear due to the complexity and multiplicity of processes underlying response inhibition. We used a modified Go/NoGo task varying uncertainty about Go or NoGo responses to determine how changes in response inhibition are related to STN local field potentials measured in 19 PD patients operated for STN-DBS. When engaged in the task, low-frequency band (LFB, 2–7 Hz; including the theta band, 4–7 Hz) power was significantly increased by dopamine treatment. LFB power significantly increased when there was uncertainty about the requirement of executing or withholding a response compared to when a response was certain. Increases in LFB power in individual trials were also significantly associated with faster reaction times. By contrast, beta band (12–30 Hz) power exhibited an inverted profile: It was significantly decreased by dopamine treatment, increased by response certainty and associated with slower reaction times. Our results suggest that STN low-frequency activity during voluntary behaviour may complement and enhance information obtained from the beta band and should be considered as a possible biomarker for the regulation of inhibition in uncertain contexts.","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143581863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0