European Journal of Neuroscience最新文献_第9页

Body Ownership and the Motor System: Rapid Facilitation of Embodied Fake Hand Movement on Actual Movement Execution

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-03 DOI: 10.1111/ejn.70035

Satoshi Shibuya, Yukari Ohki

{"title":"Body Ownership and the Motor System: Rapid Facilitation of Embodied Fake Hand Movement on Actual Movement Execution","authors":"Satoshi Shibuya, Yukari Ohki","doi":"10.1111/ejn.70035","DOIUrl":"https://doi.org/10.1111/ejn.70035","url":null,"abstract":"<div>\u0000 \u0000 <p>Body ownership—the perception that one's body belongs to oneself—has been explored using a rubber hand illusion, in which individuals misperceive a fake hand as their own (i.e., embodiment of the fake hand) when an unseen real hand and a visible fake hand are stroked synchronously. Thus, the movement of an embodied fake body may be represented in one's own sensorimotor system. Using a combination of the rubber hand illusion and a motor task, we investigated whether simple movement of the embodied fake hand influenced the subsequent movement of the participants' hand. The participants lifted their own index finger immediately upon observing the index finger lifting on the embodied (rubber hand illusion) or non-embodied (non-rubber hand illusion) fake hand (Experiment 1), and a light-emitting diode turning on near the fake hand (Experiment 2). The reaction times, peak velocities, and peak acceleration were extracted from the participants' finger-lifting movements. In Experiment 1, the reaction time was significantly shorter in the rubber hand illusion condition than in the non-rubber hand illusion condition, suggesting the rapid facilitation effect of embodied fake hand movement on actual movement. However, no such motor facilitation was observed in Experiment 2, confirming that the improved reaction time in Experiment 1 resulted from the visual movement of the fake hand rather than attention to the fake hand itself. In contrast to the reaction time, the peak velocity and acceleration did not differ significantly in either experiment. These findings reflect the similar sensorimotor representations of illusory and actual self-movement.</p>\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aging Impacts Basic Auditory and Timing Processes

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-03 DOI: 10.1111/ejn.70031

Antonio Criscuolo, Michael Schwartze, Leonardo Bonetti, Sonja A. Kotz

{"title":"Aging Impacts Basic Auditory and Timing Processes","authors":"Antonio Criscuolo, Michael Schwartze, Leonardo Bonetti, Sonja A. Kotz","doi":"10.1111/ejn.70031","DOIUrl":"https://doi.org/10.1111/ejn.70031","url":null,"abstract":"<p>Deterioration in the peripheral and central auditory systems is common in older adults and often leads to hearing and speech comprehension difficulties. Even when hearing remains intact, electrophysiological data of older adults frequently exhibit altered neural responses along the auditory pathway, reflected in variability in phase alignment of neural activity to speech sound onsets. However, it remains unclear whether challenges in speech processing in aging stem from more fundamental deficits in auditory and timing processes. Here, we investigated if and how aging individuals encoded temporal regularities in isochronous auditory sequences presented at 1.5Hz, and if they employed adaptive mechanisms of neural phase alignment in anticipation of next sound onsets. We recorded EEG in older and young individuals listening to simple isochronous tone sequences. We show that aging individuals displayed larger event-related neural responses, an increased 1/F slope, but reduced phase-coherence at the stimulation frequency (1.5Hz) and a reduced slope of phase-coherence over time in the delta and theta frequency-bands. These observations suggest altered top-down modulatory inhibition when processing repeated and predictable sounds in a sequence and altered mechanisms of continuous phase-alignment to expected sound onsets in aging. Given that deteriorations in these basic timing capacities may affect other higher-order cognitive processes (e.g., attention, perception, and action), these results underscore the need for future research examining the link between basic timing abilities and general cognition across the lifespan.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Naturalistic Audiovisual Illusions Reveal the Cortical Sites Involved in the Multisensory Processing of Speech

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-03-03 DOI: 10.1111/ejn.70043

Pierre Mégevand, Raphaël Thézé, Ashesh D. Mehta

{"title":"Naturalistic Audiovisual Illusions Reveal the Cortical Sites Involved in the Multisensory Processing of Speech","authors":"Pierre Mégevand, Raphaël Thézé, Ashesh D. Mehta","doi":"10.1111/ejn.70043","DOIUrl":"https://doi.org/10.1111/ejn.70043","url":null,"abstract":"<div>\u0000 \u0000 <p>Audiovisual speech illusions are a spectacular illustration of the effect of visual cues on the perception of speech. Because they allow dissociating perception from the physical characteristics of the sensory inputs, these illusions are useful to investigate the cerebral processing of audiovisual speech. However, the meaningless, monosyllabic utterances typically used to induce illusions are far removed from natural communication through speech. We developed naturalistic speech stimuli that embed mismatched auditory and visual cues within grammatically correct sentences to induce illusory perceptions in controlled fashion. Using intracranial EEG, we confirmed that the cortical processing of audiovisual speech recruits an ensemble of areas, from auditory and visual cortices to multisensory and associative regions. Importantly, we were able to resolve which cortical areas are driven more by the auditory or the visual contents of the speech stimulus or by the eventual perceptual report. Our results suggest that higher order sensory and associative areas, rather than early sensory cortices, are key loci for illusory perception. Naturalistic audiovisual speech illusions represent a powerful tool to dissect the specific roles of individual cortical areas in the processing of audiovisual speech.</p>\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 5","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical Regions and Connections Form Pathways and Clusters in the Mouse Brain

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-02-25 DOI: 10.1111/ejn.16673

Christianus F. Hotama, Jerald D. Kralik, Jaeseung Jeong

{"title":"Critical Regions and Connections Form Pathways and Clusters in the Mouse Brain","authors":"Christianus F. Hotama, Jerald D. Kralik, Jaeseung Jeong","doi":"10.1111/ejn.16673","DOIUrl":"https://doi.org/10.1111/ejn.16673","url":null,"abstract":"<div>\u0000 \u0000 <p>Connectome network analysis across multiple species should help identify principles of brain function. Here, we examined three fundamental properties—global efficiency, global betweenness centrality, and global clustering—in the mesoscale tract-tracing data of the mouse connectome; and conducted vulnerability analysis to identify the critical regions and connections based on the loss in network function when each brain region (213) and connection (16,594) was removed. Robustness tests examining noise effects were also conducted. There were five key findings. First, we identified eight critical regions and 38 critical connections, with more central, limbic regions dominant; and with robustness analysis showing (a) the importance of connection strength; and (b) the findings being robust to noise. Second, although critical regions and connections were significantly based on their local network properties, global influences sometimes deviated from local ones (e.g., critical globally but with lower local scores), thereby revealing global-level interactions. Third, the critical components organized into two main pathways (one from piriform cortex to globus pallidus; the other, entorhinal cortex to the amygdala), and two main clusters (centred on caudoputamen and entorhinal cortex). Fourth, for brain function, all main categories from perception to action were represented: e.g., olfaction (piriform cortex), learning and memory (entorhinal cortex), affect (amygdala and caudoputamen), and cognitive and motor processing (caudoputamen, globus pallidus). Finally, the claustrum was intriguingly identified as critical, perhaps for information integration and motor translation. Vulnerability analysis provides a unique approach to characterizing the fundamental structure of nervous systems.</p>\u0000 </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EEG Correlates of Cognitive Dynamics in Task Resumption After Interruptions: The Impact of Available Time and Flexibility

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-02-24 DOI: 10.1111/ejn.70027

Soner Ülkü, Stephan Getzmann, Edmund Wascher, Daniel Schneider

{"title":"EEG Correlates of Cognitive Dynamics in Task Resumption After Interruptions: The Impact of Available Time and Flexibility","authors":"Soner Ülkü, Stephan Getzmann, Edmund Wascher, Daniel Schneider","doi":"10.1111/ejn.70027","DOIUrl":"https://doi.org/10.1111/ejn.70027","url":null,"abstract":"<p>Interruptions are a common aspect of everyday working life, negatively affecting both task performance and long-term psychological well-being. However, research suggests that the effects of interruptions can be mitigated in several ways, such as the opportunity to anticipate the interruptions and preparation time. Here, we used a retrospective visual working memory task to investigate the effects of duration and flexible resumption after interruptions, with 28 participants (18–30 years old) attending the experiment. For this main task participants were required to remember the orientations of a set of coloured bars and retrieve one at the end of the trial in response to a retro-cue. This task was sometimes interrupted with an arithmetic task that was presented before the retro-cue. The period after the interruptions and the retro-cue was either short (no additional time), long (additional 1000 ms), or self-determined. Interruptions affected the main task performance irrespective of duration condition, but response times were shorter with the flexible condition. EEG analysis showed that having more time before resuming the interrupted task enabled stronger beta suppression which in turn modulated task performance, helping participants to safely disengage from the interrupting task, and refocus their attention back more efficiently. Further, flexibility in the timing of resumption provided additional benefits as seen in stronger oscillatory alpha and beta suppression to the retro-cue, also being related to better task performance. These results demonstrate the important role of resumption time and individual flexibility in dealing with interruptions.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrating optogenetic stimulation of olfactory bulb glomeruli with foot shock fear conditioning: A robust method for investigating olfactory-based fear conditioning

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-02-24 DOI: 10.1111/ejn.16627

Praveen Kuruppath

引用次数: 0

Peripherin, A New Promising Biomarker in Neurological Disorders

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-02-24 DOI: 10.1111/ejn.70030

Carlo Manco, Delia Righi, Guido Primiano, Angela Romano, Marco Luigetti, Luca Leonardi, Nicola De Stefano, Domenico Plantone

{"title":"Peripherin, A New Promising Biomarker in Neurological Disorders","authors":"Carlo Manco, Delia Righi, Guido Primiano, Angela Romano, Marco Luigetti, Luca Leonardi, Nicola De Stefano, Domenico Plantone","doi":"10.1111/ejn.70030","DOIUrl":"https://doi.org/10.1111/ejn.70030","url":null,"abstract":"<p>Peripherin is a class III intermediate filament protein that has recently gained attention as a potential biomarker for axonal damage in the peripheral nervous system. This review examines peripherin gene expression, protein structure, and its functions in both healthy and diseased states. Peripherin is predominantly expressed in the peripheral nervous system, especially in motor and sensory neurons, and plays a critical role in neurite growth, stability, and axonal transport during myelination. Its expression is regulated by various cytokines and undergoes several post-transcriptional modifications. Peripherin interacts with multiple proteins, including neurofilaments and kinases, influencing cytoskeletal dynamics and neuronal functions. The review also explores peripherin involvement in several neurological disorders, such as Amyotrophic Lateral Sclerosis, where its abnormal expression and aggregation contribute to disease pathology. Additionally, peripherin has been linked to polyneuropathies, traumatic axonal injury, and diabetic neuropathy, suggesting its broader relevance as a biomarker in these conditions. The potential of peripherin as a biomarker is further supported by recent studies using ultrasensitive detection methods, which have identified elevated peripherin levels in the serum of patients with neurological diseases. Despite the promising findings, the application of peripherin as a biomarker in clinical settings remains limited, primarily due to challenges in its detection and the need for further validation in diverse patient populations. Future research directions include the development of more sensitive assays and the exploration of peripherin's role in non-neuronal tissues, which may expand its diagnostic and therapeutic potential.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Properties of Hippocampal Mossy Fibre Synapses in VAMP7 KO Mice

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-02-23 DOI: 10.1111/ejn.70016

Bernat González i Llinares, Lydia Danglot, Thierry Galli, Christophe Mulle

引用次数: 0

Cerebral Lateralization During Handwritten and Typed Word Generation: A Functional Transcranial Doppler Ultrasound Study in Left-Handers and Right-Handers

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-02-20 DOI: 10.1111/ejn.70013

Christos Samsouris, Konstantina A. Papadopoulou, Nicholas A. Badcock, Filippos Vlachos, Phivos Phylactou, Marietta Papadatou-Pastou

{"title":"Cerebral Lateralization During Handwritten and Typed Word Generation: A Functional Transcranial Doppler Ultrasound Study in Left-Handers and Right-Handers","authors":"Christos Samsouris, Konstantina A. Papadopoulou, Nicholas A. Badcock, Filippos Vlachos, Phivos Phylactou, Marietta Papadatou-Pastou","doi":"10.1111/ejn.70013","DOIUrl":"https://doi.org/10.1111/ejn.70013","url":null,"abstract":"<p>Cerebral lateralization of written language, much like oral language, is predominantly left lateralized. However, handwriting has been the primary focus in lateralization studies. The cerebral lateralization of typing—a widely used method of writing—remains unexamined. This preregistered study aimed to explore the cerebral lateralization of typing versus handwriting and to investigate possible handedness-related differences. We hypothesized that (i) cerebral lateralization would not differ between the two writing methods after movement correction and (ii) both handwriting and typing would show weaker lateralization in left-handers compared to right-handers. To investigate this, we used functional transcranial Doppler (fTCD) ultrasound, a reliable method for assessing cerebral lateralization during language tasks that remains unaffected by movement artifacts, such as those generated by handwriting and typing. A total of 24 left-handers and 30 right-handers participated, performing written word generation through both handwriting and typing on a computer keyboard while undergoing fTCD assessment. We applied a Bayesian framework for our analysis, as it enables us to demonstrate the absence of a difference (i.e., no difference between two variables), which is not possible with the use of <i>p</i> values (estimated under the frequentist framework). Our results provided evidence supporting the absence of a difference in cerebral lateralization between handwriting and typing after movement correction. However, we found no conclusive evidence to either support or refute a difference in lateralization between left-handers and right-handers, suggesting that more research is needed to clarify the role of handedness in cerebral lateralization for different writing methods.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70013","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143447202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extremely Low-Frequency and Low-Intensity Electromagnetic Field Technology (ELF-EMF) Sculpts Microtubules

IF 2.7 4区医学

European Journal of Neuroscience Pub Date : 2025-02-18 DOI: 10.1111/ejn.70023

Alexandra Lobyntseva, Maram Ganaiem, Yanina Ivashko-Pachima, Colin J. Barnstable, Batsheva Weisinger, Ana Parabucki, Yaron Segal, Esther Shohami, Illana Gozes

{"title":"Extremely Low-Frequency and Low-Intensity Electromagnetic Field Technology (ELF-EMF) Sculpts Microtubules","authors":"Alexandra Lobyntseva, Maram Ganaiem, Yanina Ivashko-Pachima, Colin J. Barnstable, Batsheva Weisinger, Ana Parabucki, Yaron Segal, Esther Shohami, Illana Gozes","doi":"10.1111/ejn.70023","DOIUrl":"https://doi.org/10.1111/ejn.70023","url":null,"abstract":"<p>Aberrant microtubule dynamics coupled with a reduction in Tau-microtubule interaction are at the core of neuronal injuries resulting in microtubule disruption and aggregates of abnormally phosphorylated Tau. These pathological Tau aggregates define tauopathies such as Alzheimer's disease (<span>AD</span>), as well as the pathological sequelae following traumatic brain injury (TBI), stroke and spinal cord injury (SCI). We hypothesized that differential applications of extremely low-frequency and low-intensity electromagnetic field (ELF-EMF) will change microtubule function. To examine our hypothesis, we pre-applied ELF-EMF to a neuroblastoma neuronal cell line later exposed to 4 h of zinc intoxication, modelling Tau-microtubule dissociation. ELF-EMF (40 Hz and 1 G; multiple exposure schedules) enhanced microtubule dynamics and increased Tau-microtubule interaction in the face of zinc toxicity. Complementing these preconditioning neuroprotective effects, concomitant 1 h treatment protocols comparing 3.9 or 40 Hz and 1 G exposure, indicated effects on Tau phosphorylation accentuated with 40 Hz and reduction in beta tubulin isotypes, depending on electromagnetic frequencies, most pronounced at 3.9 Hz. Our results discovered ELF-EMF modulation on the microtubule cytoskeleton essential for brain health.</p>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"61 4","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/ejn.70023","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143438912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0