{"title":"模拟昼夜节律对离子动力学的影响及抗癫痫药物的作用。","authors":"Dlima Nesrine, Carrere Marcel, Bedoui Mohamed Hedi, Damien Depannemaecker","doi":"10.1111/ejn.70265","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>This study examines the interaction between circadian rhythms and the cellular mechanisms underlying epileptic seizures by introducing a circadian modulation into the Epileptor-2 model. A time-dependent factor was implemented to reproduce daily fluctuations in neuronal excitability and seizure occurrence, and its interaction with pharmacological treatments was modeled. The pharmacokinetics of antiepileptic drugs were incorporated to evaluate the effects of dose adjustments and administration schedules aligned with circadian rhythm. Simulations show that including circadian fluctuations in ionic dynamics modifies neuronal excitability and seizure onset and that optimizing dose timing to periods of highest susceptibility can enhance treatment efficacy and reduce seizure risk. These results provide a mechanistic link between ionic-level dynamics and macroscopic biological rhythms and support the potential of personalized chronotherapy for improving epilepsy management.</p>\n </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"62 7","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Modeling the Influence of Circadian Rhythm on Ionic Dynamics and the Effect of Antiepileptic Drugs\",\"authors\":\"Dlima Nesrine, Carrere Marcel, Bedoui Mohamed Hedi, Damien Depannemaecker\",\"doi\":\"10.1111/ejn.70265\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>This study examines the interaction between circadian rhythms and the cellular mechanisms underlying epileptic seizures by introducing a circadian modulation into the Epileptor-2 model. A time-dependent factor was implemented to reproduce daily fluctuations in neuronal excitability and seizure occurrence, and its interaction with pharmacological treatments was modeled. The pharmacokinetics of antiepileptic drugs were incorporated to evaluate the effects of dose adjustments and administration schedules aligned with circadian rhythm. Simulations show that including circadian fluctuations in ionic dynamics modifies neuronal excitability and seizure onset and that optimizing dose timing to periods of highest susceptibility can enhance treatment efficacy and reduce seizure risk. These results provide a mechanistic link between ionic-level dynamics and macroscopic biological rhythms and support the potential of personalized chronotherapy for improving epilepsy management.</p>\\n </div>\",\"PeriodicalId\":11993,\"journal\":{\"name\":\"European Journal of Neuroscience\",\"volume\":\"62 7\",\"pages\":\"\"},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2025-09-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/ejn.70265\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/ejn.70265","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Modeling the Influence of Circadian Rhythm on Ionic Dynamics and the Effect of Antiepileptic Drugs
This study examines the interaction between circadian rhythms and the cellular mechanisms underlying epileptic seizures by introducing a circadian modulation into the Epileptor-2 model. A time-dependent factor was implemented to reproduce daily fluctuations in neuronal excitability and seizure occurrence, and its interaction with pharmacological treatments was modeled. The pharmacokinetics of antiepileptic drugs were incorporated to evaluate the effects of dose adjustments and administration schedules aligned with circadian rhythm. Simulations show that including circadian fluctuations in ionic dynamics modifies neuronal excitability and seizure onset and that optimizing dose timing to periods of highest susceptibility can enhance treatment efficacy and reduce seizure risk. These results provide a mechanistic link between ionic-level dynamics and macroscopic biological rhythms and support the potential of personalized chronotherapy for improving epilepsy management.
期刊介绍：
EJN is the journal of FENS and supports the international neuroscientific community by publishing original high quality research articles and reviews in all fields of neuroscience. In addition, to engage with issues that are of interest to the science community, we also publish Editorials, Meetings Reports and Neuro-Opinions on topics that are of current interest in the fields of neuroscience research and training in science. We have recently established a series of ‘Profiles of Women in Neuroscience’. Our goal is to provide a vehicle for publications that further the understanding of the structure and function of the nervous system in both health and disease and to provide a vehicle to engage the neuroscience community. As the official journal of FENS, profits from the journal are re-invested in the neuroscientific community through the activities of FENS.
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