显性和服从性小鼠不同的脑电活动模式:对认知障碍的影响

IF 2.7 4区 医学 Q3 NEUROSCIENCES
Maryia Bairachnaya, Alexey Shnyder, Albert Pinhasov, Izhak Michaelevski
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引用次数: 0

摘要

前额叶、视觉和后顶叶皮层是认知、社会互动和新奇识别的关键,但社会等级和内在应激敏感性对它们相互作用的影响尚未得到充分研究。我们的研究结果揭示了应激弹性优势小鼠(Dom)和应激敏感顺从小鼠(Sub)之间的显著神经差异,特别是在θ波段功率、区域间相干性和相位振幅耦合方面。Dom小鼠表现出较低的θ相干性和前额叶和视觉皮层之间θ - γ相位振幅耦合的动态变化,这与更好的记忆回忆和认知灵活性有关。此外,Dom小鼠在识别任务中显示出左到右视觉皮层连接增加,这与成功的新颖性辨别有关,而Sub小鼠缺乏这种由theta驱动的因果关系。这些结果表明,与社会等级相关的应激敏感性改变了神经活动和连通性,导致Dom和Sub小鼠在新颖性识别任务中的不同表现,为靶向theta驱动的连接提供了潜在的诊断和治疗意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Distinct Brain Electrical Activity Patterns in Dominant and Submissive Mice: Implications for Cognitive Impairments

The prefrontal, visual, and posterior parietal cortices are key to cognition, social interaction, and novelty recognition, but the impact of social hierarchy and inherent stress sensitivity on their interplay remains underexplored. Our findings reveal significant neural differences between stress-resilient dominant (Dom) and stress-sensitive submissive (Sub) mice, particularly in theta band power, inter-regional coherence, and phase–amplitude coupling. Dom mice exhibited reduced theta coherence and dynamic changes in theta-gamma phase amplitude coupling between the prefrontal and visual cortices, which were associated with better memory recall and cognitive flexibility. In addition, Dom mice showed increased left-to-right visual cortex connectivity during the recognition task, linked to successful novelty discrimination, while Sub mice lacked this theta-driven causality. These results suggest that stress sensitivity associated with social rank alters neural activity and connectivity, contributing to the differing performance of Dom and Sub mice in novelty recognition tasks, providing potential diagnostic and therapeutic implications for targeting theta-driven connectivity.

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来源期刊
European Journal of Neuroscience
European Journal of Neuroscience 医学-神经科学
CiteScore
7.10
自引率
5.90%
发文量
305
审稿时长
3.5 months
期刊介绍: EJN is the journal of FENS and supports the international neuroscientific community by publishing original high quality research articles and reviews in all fields of neuroscience. In addition, to engage with issues that are of interest to the science community, we also publish Editorials, Meetings Reports and Neuro-Opinions on topics that are of current interest in the fields of neuroscience research and training in science. We have recently established a series of ‘Profiles of Women in Neuroscience’. Our goal is to provide a vehicle for publications that further the understanding of the structure and function of the nervous system in both health and disease and to provide a vehicle to engage the neuroscience community. As the official journal of FENS, profits from the journal are re-invested in the neuroscientific community through the activities of FENS.
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