Maryia Bairachnaya, Alexey Shnyder, Albert Pinhasov, Izhak Michaelevski
{"title":"显性和服从性小鼠不同的脑电活动模式:对认知障碍的影响","authors":"Maryia Bairachnaya, Alexey Shnyder, Albert Pinhasov, Izhak Michaelevski","doi":"10.1111/ejn.70184","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>The prefrontal, visual, and posterior parietal cortices are key to cognition, social interaction, and novelty recognition, but the impact of social hierarchy and inherent stress sensitivity on their interplay remains underexplored. Our findings reveal significant neural differences between stress-resilient dominant (Dom) and stress-sensitive submissive (Sub) mice, particularly in theta band power, inter-regional coherence, and phase–amplitude coupling. Dom mice exhibited reduced theta coherence and dynamic changes in theta-gamma phase amplitude coupling between the prefrontal and visual cortices, which were associated with better memory recall and cognitive flexibility. In addition, Dom mice showed increased left-to-right visual cortex connectivity during the recognition task, linked to successful novelty discrimination, while Sub mice lacked this theta-driven causality. These results suggest that stress sensitivity associated with social rank alters neural activity and connectivity, contributing to the differing performance of Dom and Sub mice in novelty recognition tasks, providing potential diagnostic and therapeutic implications for targeting theta-driven connectivity.</p>\n </div>","PeriodicalId":11993,"journal":{"name":"European Journal of Neuroscience","volume":"62 2","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Distinct Brain Electrical Activity Patterns in Dominant and Submissive Mice: Implications for Cognitive Impairments\",\"authors\":\"Maryia Bairachnaya, Alexey Shnyder, Albert Pinhasov, Izhak Michaelevski\",\"doi\":\"10.1111/ejn.70184\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>The prefrontal, visual, and posterior parietal cortices are key to cognition, social interaction, and novelty recognition, but the impact of social hierarchy and inherent stress sensitivity on their interplay remains underexplored. Our findings reveal significant neural differences between stress-resilient dominant (Dom) and stress-sensitive submissive (Sub) mice, particularly in theta band power, inter-regional coherence, and phase–amplitude coupling. Dom mice exhibited reduced theta coherence and dynamic changes in theta-gamma phase amplitude coupling between the prefrontal and visual cortices, which were associated with better memory recall and cognitive flexibility. In addition, Dom mice showed increased left-to-right visual cortex connectivity during the recognition task, linked to successful novelty discrimination, while Sub mice lacked this theta-driven causality. These results suggest that stress sensitivity associated with social rank alters neural activity and connectivity, contributing to the differing performance of Dom and Sub mice in novelty recognition tasks, providing potential diagnostic and therapeutic implications for targeting theta-driven connectivity.</p>\\n </div>\",\"PeriodicalId\":11993,\"journal\":{\"name\":\"European Journal of Neuroscience\",\"volume\":\"62 2\",\"pages\":\"\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-07-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European Journal of Neuroscience\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/ejn.70184\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/ejn.70184","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Distinct Brain Electrical Activity Patterns in Dominant and Submissive Mice: Implications for Cognitive Impairments
The prefrontal, visual, and posterior parietal cortices are key to cognition, social interaction, and novelty recognition, but the impact of social hierarchy and inherent stress sensitivity on their interplay remains underexplored. Our findings reveal significant neural differences between stress-resilient dominant (Dom) and stress-sensitive submissive (Sub) mice, particularly in theta band power, inter-regional coherence, and phase–amplitude coupling. Dom mice exhibited reduced theta coherence and dynamic changes in theta-gamma phase amplitude coupling between the prefrontal and visual cortices, which were associated with better memory recall and cognitive flexibility. In addition, Dom mice showed increased left-to-right visual cortex connectivity during the recognition task, linked to successful novelty discrimination, while Sub mice lacked this theta-driven causality. These results suggest that stress sensitivity associated with social rank alters neural activity and connectivity, contributing to the differing performance of Dom and Sub mice in novelty recognition tasks, providing potential diagnostic and therapeutic implications for targeting theta-driven connectivity.
期刊介绍:
EJN is the journal of FENS and supports the international neuroscientific community by publishing original high quality research articles and reviews in all fields of neuroscience. In addition, to engage with issues that are of interest to the science community, we also publish Editorials, Meetings Reports and Neuro-Opinions on topics that are of current interest in the fields of neuroscience research and training in science. We have recently established a series of ‘Profiles of Women in Neuroscience’. Our goal is to provide a vehicle for publications that further the understanding of the structure and function of the nervous system in both health and disease and to provide a vehicle to engage the neuroscience community. As the official journal of FENS, profits from the journal are re-invested in the neuroscientific community through the activities of FENS.