Environmental Health Perspectives最新文献

{"title":"Mapping Climate-Related Hazards along Migration Routes: A Mixed Methods Study of Hypertensive Syrian and Iraqi Refugees Resettled in San Diego, California.","authors":"Behnan Albahsahli, Anna Dimitrova, Nadine Kadri, Tarik Benmarhnia, Tala Al-Rousan","doi":"10.1289/EHP14632","DOIUrl":"10.1289/EHP14632","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 9","pages":"97701"},"PeriodicalIF":10.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial Variability in Relationships between Early Childhood Lead Exposure and Standardized Test Scores in Fourth Grade North Carolina Public School Students (2013-2016).","authors":"Mercedes A Bravo, Daniel R Kowal, Dominique Zephyr, Joseph Feldman, Katherine Ensor, Marie Lynn Miranda","doi":"10.1289/EHP13898","DOIUrl":"10.1289/EHP13898","url":null,"abstract":"<p><strong>Background: </strong>Exposure to lead during childhood is detrimental to children's health. The extent to which the association between lead exposure and elementary school academic outcomes varies across geography is not known.</p><p><strong>Objective: </strong>Estimate associations between blood lead levels (BLLs) and fourth grade standardized test scores in reading and mathematics in North Carolina using models that allow associations between BLL and test scores to vary spatially across communities.</p><p><strong>Methods: </strong>We link geocoded, individual-level, standardized test score data for North Carolina public school students in fourth grade (2013-2016) with detailed birth records and blood lead testing data retrieved from the North Carolina childhood blood lead state registry on samples typically collected at 1-6 y of age. BLLs were categorized as: <math><mrow><mn>1</mn><mspace></mspace><mi>μ</mi><mi>g</mi><mo>/</mo><mtext>dL</mtext></mrow></math> (reference), <math><mrow><mn>2</mn><mspace></mspace><mi>μ</mi><mi>g</mi><mo>/</mo><mtext>dL</mtext></mrow></math>, <math><mrow><mn>3</mn><mo>-</mo><mn>4</mn><mspace></mspace><mi>μ</mi><mi>g</mi><mo>/</mo><mtext>dL</mtext></mrow></math> and <math><mrow><mo>≥</mo><mn>5</mn><mspace></mspace><mi>μ</mi><mi>g</mi><mo>/</mo><mtext>dL</mtext></mrow></math>. We then fit spatially varying coefficient models that incorporate information sharing (smoothness), across neighboring communities via a Gaussian Markov random field to provide a global estimate of the association between BLL and test scores, as well as census tract-specific estimates (i.e., spatial coefficients). Models adjusted for maternal- and child-level covariates and were fit separately for reading and math.</p><p><strong>Results: </strong>The average BLL across the 91,706 individuals in the analysis dataset was <math><mrow><mn>2.84</mn><mspace></mspace><mi>μ</mi><mi>g</mi><mo>/</mo><mtext>dL</mtext></mrow></math>. Individuals were distributed across 2,002 (out of 2,195) census tracts in North Carolina. In models adjusting for child sex, birth weight percentile for gestational age, and Medicaid participation as well as maternal race/ethnicity, educational attainment, marital status, and tobacco use, BLLs of <math><mrow><mn>2</mn><mspace></mspace><mi>μ</mi><mi>g</mi><mo>/</mo><mtext>dL</mtext></mrow></math>, <math><mrow><mn>3</mn><mo>-</mo><mn>4</mn><mspace></mspace><mi>μ</mi><mi>g</mi><mo>/</mo><mtext>dL</mtext></mrow></math> and <math><mrow><mo>≥</mo><mn>5</mn><mspace></mspace><mi>μ</mi><mi>g</mi><mo>/</mo><mtext>dL</mtext></mrow></math> were associated with overall lower reading test scores of <math><mrow><mo>-</mo><mn>0.28</mn></mrow></math> [95% confidence interval (CI): <math><mrow><mo>-</mo><mn>0.43</mn></mrow></math>, <math><mrow><mo>-</mo><mn>0.12</mn></mrow></math>], <math><mrow><mo>-</mo><mn>0.53</mn></mrow></math> (<math><mrow><mo>-</mo><mn>0.69</mn></mrow></math>, <math><mrow><mo>-</mo><mn>0.38</mn></mrow></math>), ","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 9","pages":"97003"},"PeriodicalIF":10.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11370994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Association of Domestic Water Hardness with All-Cause and Cause-Specific Cancers: Evidence from 447,996 UK Biobank Participants\".","authors":"Hongcheng Luo, Haoliang Wu, Zhaohui He","doi":"10.1289/EHP16006","DOIUrl":"10.1289/EHP16006","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 9","pages":"98001"},"PeriodicalIF":10.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11423937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposome-Wide Ranking to Uncover Environmental Chemicals Associated with Dyslipidemia: A Panel Study in Healthy Older Chinese Adults from the BAPE Study.","authors":"Enmin Ding, Fuchang Deng, Jianlong Fang, Juan Liu, Wenyan Yan, Qiao Yao, Ke Miao, Yu Wang, Peijie Sun, Chenfeng Li, Yuanyuan Liu, Haoran Dong, Li Dong, Xu Zhang, Yifu Lu, Xiao Lin, Changming Ding, Tiantian Li, Yali Shi, Yaqi Cai, Xiaohui Liu, Krystal J Godri Pollitt, John S Ji, Shilu Tong, Song Tang, Xiaoming Shi","doi":"10.1289/EHP13864","DOIUrl":"10.1289/EHP13864","url":null,"abstract":"<p><strong>Background: </strong>Environmental contaminants (ECs) are increasingly recognized as crucial drivers of dyslipidemia and cardiovascular disease (CVD), but the comprehensive impact spectrum and interlinking mechanisms remain uncertain.</p><p><strong>Objectives: </strong>We aimed to systematically evaluate the association between exposure to 80 ECs across seven divergent categories and markers of dyslipidemia and investigate their underpinning biomolecular mechanisms via an unbiased integrative approach of internal chemical exposome and multi-omics.</p><p><strong>Methods: </strong>A longitudinal study involving 76 healthy older adults was conducted in Jinan, China, and participants were followed five times from 10 September 2018 to 19 January 2019 in 1-month intervals. A broad spectrum of seven chemical categories covering the prototypes and metabolites of 102 ECs in serum or urine as well as six serum dyslipidemia markers [total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apolipoprotein (Apo)A1, ApoB, and ApoE4] were measured. Multi-omics, including the blood transcriptome, serum/urine metabolome, and serum lipidome, were profiled concurrently. Exposome-wide association study and the deletion/substitution/addition algorithms were applied to explore the associations between 80 EC exposures detection frequency <math><mrow><mo>></mo><mn>50</mn><mo>%</mo></mrow></math> and dyslipidemia markers. Weighted quantile sum regression was used to assess the mixture effects and relative contributions. Multi-omics profiling, causal inference model, and pathway analysis were conducted to interpret the mediating biomolecules and underlying mechanisms. Examination of cytokines and electrocardiograms was further conducted to validate the observed associations and biomolecular pathways.</p><p><strong>Results: </strong>Eight main ECs [1-naphthalene, 1-pyrene, 2-fluorene, dibutyl phosphate, tri-phenyl phosphate, mono-(2-ethyl-5-hydroxyhexyl) phthalate, chromium, and vanadium] were significantly associated with most dyslipidemia markers. Multi-omics indicated that the associations were mediated by endogenous biomolecules and pathways, primarily pertinent to CVD, inflammation, and metabolism. Clinical measures of cytokines and electrocardiograms further cross-validated the association of these exogenous ECs with systemic inflammation and cardiac function, demonstrating their potential mechanisms in driving dyslipidemia pathogenesis.</p><p><strong>Discussion: </strong>It is imperative to prioritize mitigating exposure to these ECs in the primary prevention and control of the dyslipidemia epidemic. https://doi.org/10.1289/EHP13864.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 9","pages":"97005"},"PeriodicalIF":10.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11379127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Base Hit: Neurological Diseases and Genetic Susceptibilities to Pesticide Exposures.","authors":"Carrie Arnold","doi":"10.1289/EHP15412","DOIUrl":"10.1289/EHP15412","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 9","pages":"94001"},"PeriodicalIF":10.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11379126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142143046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Skin Care Products on Phthalates and Phthalate Replacements in Children: the ECHO-FGS.","authors":"Michael S Bloom, Juliana M Clark, John L Pearce, Pamela L Ferguson, Roger B Newman, James R Roberts, William A Grobman, Anthony C Sciscione, Daniel W Skupski, Kelly Garcia, John E Vena, Kelly J Hunt","doi":"10.1289/EHP13937","DOIUrl":"10.1289/EHP13937","url":null,"abstract":"<p><strong>Background: </strong>Phthalates and their replacements have been implicated as developmental toxicants. Young children may be exposed to phthalates/replacements when using skin care products (SCPs).</p><p><strong>Objectives: </strong>Our objective is to assess the associations between use of SCPs and children's urinary phthalate/replacement metabolite concentrations.</p><p><strong>Methods: </strong>Children (4-8 years old) from the Environmental Influences on Child Health Outcomes-Fetal Growth Study (ECHO-FGS) cohort provided spot urine samples from 2017 to 2019, and mothers were queried about children's SCP use in the past 24 h (<math><mrow><mi>n</mi><mo>=</mo><mn>906</mn></mrow></math>). Concentrations of 16 urinary phthalate/replacement metabolites were determined by liquid chromatography-tandem mass spectrometry (<math><mrow><mi>n</mi><mo>=</mo><mn>630</mn></mrow></math>). We used linear regression to estimate the child's use of different SCPs as individual predictors of urinary phthalate/replacement metabolites, adjusted for urinary specific gravity, age, sex assigned at birth, body mass index, and self-reported race/ethnic identity, as well as maternal education, and season of specimen collection. We created self-organizing maps (SOM) to group children into \"exposure profiles\" that reflect discovered patterns of use for multiple SCPs.</p><p><strong>Results: </strong>Children had lotions applied (43.0%) frequently, but \"2-in-1\" hair-care products (7.5%), sunscreens (5.9%), and oils (4.3%) infrequently. Use of lotions was associated with 1.17-fold [95% confidence interval (CI): 1.00, 1.34] greater mono-benzyl phthalate and oils with 2.86-fold (95% CI: 1.89, 4.31) greater monoethyl phthalate (MEP), 1.43-fold (95% CI: 1.09, 1.90) greater monobutyl phthalate (MBP), and 1.40-fold (95% CI: 1.22, 1.61) greater low-molecular-weight phthalates (LMW). Use of 2-in-1 haircare products was associated with 0.84-fold (95% CI: 0.72, 0.97) and 0.78-fold (95% CI: 0.62, 0.98) lesser mono(3-carboxypropyl) phthalate (MCPP) and MBP, respectively. Child's race/ethnic identity modified the associations of lotions with LMW, oils with MEP and LMW, sunscreen with MCPP, ointments with MEP, and hair conditioner with MCPP. SOM identified four distinct SCP-use exposure scenarios (i.e., profiles) within our population that predicted 1.09-fold (95% CI: 1.03, 1.15) greater mono-carboxy isononyl phthalate, 1.31-fold (95% CI: 0.98, 1.77) greater mono-2-ethyl-5-hydroxyhexyl terephthalate, 1.13-fold (95% CI: 0.99, 1.29) greater monoethylhexyl phthalate, and 1.04-fold (95% CI: 1.00, 1.09) greater diethylhexyl phthalate.</p><p><strong>Discussion: </strong>We found that reported SCP use was associated with urinary phthalate/replacement metabolites in young children. These results may inform policymakers, clinicians, and parents to help limit children's exposure to developmental toxicants. https://doi.org/10.1289/EHP13937.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 9","pages":"97001"},"PeriodicalIF":10.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11373421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invited Perspective: Changing Places-How Moving Histories Can Help Map the Health Impacts of People's Environmental Exposures.","authors":"Meredith Pedde, Sara D Adar","doi":"10.1289/EHP16145","DOIUrl":"10.1289/EHP16145","url":null,"abstract":"","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 9","pages":"91303"},"PeriodicalIF":10.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11441637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142344005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigenetic Biomarker: Improving Estimates of Fetal Exposure to Cigarette Smoke.","authors":"Silke Schmidt","doi":"10.1289/EHP15627","DOIUrl":"10.1289/EHP15627","url":null,"abstract":"<p><p>The well-known cotinine test captures recent smoking, and survey responses are not always accurate. Now researchers propose a measure of DNA methylation in placental tissue that may be better than either.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 9","pages":"94002"},"PeriodicalIF":10.1,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11421290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<ArticleTitle xmlns:ns0=\"http://www.w3.org/1998/Math/MathML\">Effects of Naphtho[2,1-<i>a</i>]pyrene Exposure on CYP1A1 Expression: An <i>in Vivo</i> and <i>in Vitro</i> Mechanistic Study Exploring the Role of <ns0:math><ns0:mrow><ns0:mrow><ns0:msup><ns0:mrow><ns0:mi>m</ns0:mi></ns0:mrow><ns0:mrow><ns0:mi>6</ns0:mi></ns0:mrow></ns0:msup></ns0:mrow><ns0:mi>A</ns0:mi></ns0:mrow></ns0:math> Posttranscriptional Modification.","authors":"Jiemiao Shen, Li Wang, Wen Zhang, Xing Gong, Sheng Li, Xuyan Zou, Chao Chen, Rong Xia, Di Zhang, Shuyu Xu, Jiayi Xu, Shaozhuo Wang, Yinyue Jiang, Hong Sun, Chao Wang, Shou-Lin Wang","doi":"10.1289/EHP14055","DOIUrl":"10.1289/EHP14055","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Currently, many emerging polycyclic aromatic hydrocarbons (PAHs) have been found to be widely present in the environment. However, little has been reported about their toxicity, particularly in relation to CYP1A1.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;This study aimed to explore the toxicity of naphtho[2,1-&lt;i&gt;a&lt;/i&gt;]pyrene (N21aP) and elucidate the mechanism underlying N21aP-induced expression of CYP1A1.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The concentration and sources of N21aP were detected and analyzed by gas chromatography-triple quadrupole mass spectrometry (GC-MS/MS) and diagnostic ratio analysis. Then the effects of CYP1A1 on the toxicity of N21aP were conducted in male wild-type (WT) and &lt;i&gt;Cyp1a1&lt;/i&gt; knockout mice exposed to N21aP (0.02, 0.2, and &lt;math&gt;&lt;mrow&gt;&lt;mn&gt;2&lt;/mn&gt;&lt;mspace&gt;&lt;/mspace&gt;&lt;mi&gt;mg&lt;/mi&gt;&lt;mo&gt;/&lt;/mo&gt;&lt;mi&gt;kg&lt;/mi&gt;&lt;/mrow&gt;&lt;/math&gt;) through intratracheal instillation. Further, the aryl hydrocarbon receptor (AhR) pathway was examined through luciferase and chromatin immunoprecipitation (ChIP) assays. &lt;math&gt;&lt;mrow&gt;&lt;mrow&gt;&lt;msup&gt;&lt;mrow&gt;&lt;mi&gt;N&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;6&lt;/mn&gt;&lt;/mrow&gt;&lt;/msup&gt;&lt;/mrow&gt;&lt;/mrow&gt;&lt;/math&gt;-methyladenosine (&lt;math&gt;&lt;mrow&gt;&lt;mrow&gt;&lt;msup&gt;&lt;mrow&gt;&lt;mi&gt;m&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;6&lt;/mn&gt;&lt;/mrow&gt;&lt;/msup&gt;&lt;/mrow&gt;&lt;mi&gt;A&lt;/mi&gt;&lt;/mrow&gt;&lt;/math&gt;) modification levels were measured on global RNA and specifically on &lt;i&gt;CYP1A1&lt;/i&gt; mRNA using dot blotting and methylated RNA immunoprecipitation-quantitative real-time polymerase chain reaction (MeRIP qRT-PCR), with validation by &lt;math&gt;&lt;mrow&gt;&lt;mrow&gt;&lt;msup&gt;&lt;mrow&gt;&lt;mi&gt;m&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;6&lt;/mn&gt;&lt;/mrow&gt;&lt;/msup&gt;&lt;/mrow&gt;&lt;mi&gt;A&lt;/mi&gt;&lt;/mrow&gt;&lt;/math&gt; inhibitors, DAA and SAH. &lt;math&gt;&lt;mrow&gt;&lt;mrow&gt;&lt;msup&gt;&lt;mrow&gt;&lt;mi&gt;m&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;6&lt;/mn&gt;&lt;/mrow&gt;&lt;/msup&gt;&lt;/mrow&gt;&lt;mi&gt;A&lt;/mi&gt;&lt;/mrow&gt;&lt;/math&gt; sites on &lt;i&gt;CYP1A1&lt;/i&gt; were identified by bioinformatics and luciferase assays, and &lt;i&gt;CYP1A1&lt;/i&gt; mRNA's interaction with IGF2BP3 was confirmed by RNA pull-down, luciferase, and RNA binding protein immunoprecipitation (RIP) assays.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;N21aP was of the same environmental origin as benzo[&lt;i&gt;a&lt;/i&gt;]pyrene (BaP) but was more stably present in the environment. N21aP could be metabolically activated by CYP1A1 to produce epoxides, causing DNA damage and further leading to lung inflammation. Importantly, in addition to the classical AhR pathway (i.e., BaP), N21aP also induced CYP1A1 expression with a posttranscriptional modification of &lt;math&gt;&lt;mrow&gt;&lt;mrow&gt;&lt;msup&gt;&lt;mrow&gt;&lt;mi&gt;m&lt;/mi&gt;&lt;/mrow&gt;&lt;mrow&gt;&lt;mn&gt;6&lt;/mn&gt;&lt;/mrow&gt;&lt;/msup&gt;&lt;/mrow&gt;&lt;mi&gt;A&lt;/mi&gt;&lt;/mrow&gt;&lt;/math&gt; in &lt;i&gt;CYP1A1&lt;/i&gt; mRNA via the METTL14-IGF2BP3-CYP1A1 axis. Specifically, in the two recognition sites of METTL14 on the &lt;i&gt;CYP1A1&lt;/i&gt; mRNA transcript (position at 2700 and 5218), a methylation site (position at 5218) in the 3'-untranslated region (UTR) was recognized by IGF2BP3, enhanced the stability of &lt;i&gt;CYP1A1&lt;/i&gt; mRNA, and finally resulted in an increase in CYP1A1 expression.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;This study systematically demonstrated that in addition to AhR-","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 8","pages":"87003"},"PeriodicalIF":10.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11318572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Early Life Exposures to the Aryl Hydrocarbon Receptor Ligand TCDF on Gut Microbiota and Host Metabolic Homeostasis in C57BL/6J Mice.","authors":"Yuan Tian, Bipin Rimal, Jordan E Bisanz, Wei Gui, Trenton M Wolfe, Imhoi Koo, Iain A Murray, Shaneice K Nettleford, Shigetoshi Yokoyama, Fangcong Dong, Sergei Koshkin, K Sandeep Prabhu, Peter J Turnbaugh, Seth T Walk, Gary H Perdew, Andrew D Patterson","doi":"10.1289/EHP13356","DOIUrl":"10.1289/EHP13356","url":null,"abstract":"<p><strong>Background: </strong>Exposure to persistent organic pollutants (POPs) and disruptions in the gastrointestinal microbiota have been positively correlated with a predisposition to factors such as obesity, metabolic syndrome, and type 2 diabetes; however, it is unclear how the microbiome contributes to this relationship.</p><p><strong>Objective: </strong>This study aimed to explore the association between early life exposure to a potent aryl hydrocarbon receptor (AHR) agonist and persistent disruptions in the microbiota, leading to impaired metabolic homeostasis later in life.</p><p><strong>Methods: </strong>This study used metagenomics, nuclear magnetic resonance (NMR)- and mass spectrometry (MS)-based metabolomics, and biochemical assays to analyze the gut microbiome composition and function, as well as the physiological and metabolic effects of early life exposure to 2,3,7,8-tetrachlorodibenzofuran (TCDF) in conventional, germ-free (GF), and <i>Ahr</i>-null mice. The impact of TCDF on <i>Akkermansia muciniphila</i> (<i>A. muciniphila</i>) <i>in vitro</i> was assessed using optical density (OD 600), flow cytometry, transcriptomics, and MS-based metabolomics.</p><p><strong>Results: </strong>TCDF-exposed mice exhibited lower abundances of <i>A. muciniphila</i>, lower levels of cecal short-chain fatty acids (SCFAs) and indole-3-lactic acid (ILA), as well as lower levels of the gut hormones glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), findings suggestive of disruption in the gut microbiome community structure and function. Importantly, microbial and metabolic phenotypes associated with early life POP exposure were transferable to GF recipients in the absence of POP carry-over. In addition, AHR-independent interactions between POPs and the microbiota were observed, and they were significantly associated with growth, physiology, gene expression, and metabolic activity outcomes of <i>A. muciniphila</i>, supporting suppressed activity along the ILA pathway.</p><p><strong>Conclusions: </strong>These data obtained in a mouse model point to the complex effects of POPs on the host and microbiota, providing strong evidence that early life, short-term, and self-limiting POP exposure can adversely impact the microbiome, with effects persisting into later life with associated health implications. https://doi.org/10.1289/EHP13356.</p>","PeriodicalId":11862,"journal":{"name":"Environmental Health Perspectives","volume":"132 8","pages":"87005"},"PeriodicalIF":10.1,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11323762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}